845 results match your criteria Primary Malignant Skull Tumors


Stereotactic Radiosurgery and Stereotactic Radiotherapy for Malignant Skull Base Tumors.

Cureus 2020 Jun 1;12(6):e8401. Epub 2020 Jun 1.

CyberKnife Center, Aoyama General Hospital, Toyokawa, JPN.

The role of stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) for malignant skull base tumors was summarized and discussed. The treatment of skull base tumors remains challenging. Their total resection is often difficult. Read More

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http://dx.doi.org/10.7759/cureus.8401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331921PMC

The diagnosis and management of primary and iatrogenic soft tissue sarcomas of the sella.

Pituitary 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Soft tissue sarcoma (STS) of the sella is exceptionally rare. We conducted a case series, literature review, and nationwide analysis of primary and iatrogenic (radiation-associated) STS of the sella to define the clinical course of this entity.

Methods: This study employed a multi-institutional retrospective case review, literature review, and nationwide analysis using the National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.1007/s11102-020-01062-yDOI Listing

Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.

Cancers (Basel) 2020 Jun 5;12(6). Epub 2020 Jun 5.

Jan and Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.

Background: Meningiomas constitute one-third of all primary brain tumors. Although typically benign, about 20% of these tumors recur despite surgery and radiation, and may ultimately prove fatal. There are currently no effective chemotherapies for meningioma. Read More

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http://dx.doi.org/10.3390/cancers12061478DOI Listing

A Retrospective Interventional Cohort Study to Assess the Safety and Efficacy of Sandostatin LAR for Treatment of Recurrent and/or Refractory Meningiomas.

Front Neurol 2020 6;11:373. Epub 2020 May 6.

Department of Neurology, Irvine Medical Center, University of California, Orange, Orange, CA, United States.

Meningiomas are the most common adult primary intracranial tumors in the United States. Despite high recurrence rate of atypical and malignant subtypes, there is no approved drug indicated specifically for meningioma. Since the majority of meningiomas exhibit high density of somatostatin receptors subtypes, somatostatin analogs have been under close investigation. Read More

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http://dx.doi.org/10.3389/fneur.2020.00373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218113PMC

Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms.

Vet Comp Oncol 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.

Tonsillar metastasis from distant primary tumours has not been described in dogs, and reports are rare in humans. The aims of this study were to determine whether tumour metastasis occurs to the canine palatine tonsils and evaluate whether afferent lymphatics drain to the palatine tonsils via skull indirect computed tomography lymphangiography (ICTL). Retrospective review of the diagnostic laboratory tonsillar histopathology submissions was performed. Read More

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http://dx.doi.org/10.1111/vco.12604DOI Listing

Advances in the management of primary bone sarcomas of the skull base.

J Neurooncol 2020 Apr 18. Epub 2020 Apr 18.

Departments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Skull base primary malignancies represent a heterogeneous group of histologic diagnoses and sarcomas of the skull base are specific malignant tumors that arise from mesenchymal cells and can be classified by site of origin into bony and soft tissue sarcomas. The most common bony sarcomas include: chondrosarcoma, osteosarcoma, chordoma, Ewing's sarcoma. Given the relative rarity of each histologic diagnosis, especially in the skull base, there is limited published data to guide the management of patients with skull base sarcomas. Read More

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http://dx.doi.org/10.1007/s11060-020-03497-6DOI Listing

[Treatment of primary craniofacial (sinonasal) malignant tumors affecting the anterior and middle skull base].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(1):101-108

Burdenko Neurosurgical Center, Moscow, Russia.

Sinonasal malignant tumors are characterized by high histological variability and complexity of the differential diagnosis. Currently, there are classifications of these tumors, which are based on their localization and involvement of various anatomical structures. However, generally accepted algorithms for treatment of this pathology have not yet been developed. Read More

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http://dx.doi.org/10.17116/neiro202084011101DOI Listing
January 2020

Multiple Primary Malignant Neoplasms: An Unusual Case of Metachronous Breast Ductal and Squamous Cell Carcinomas.

Cureus 2020 Feb 11;12(2):e6954. Epub 2020 Feb 11.

Internal Medicine, Howard University Hospital, Washington, D.C., USA.

Multiple primary malignant neoplasms (MPMN) are generally defined as the co-occurrence of multiple primary malignant neoplasms of distinct histology in the same individual. Second and higher-order primary malignancies now comprise about 18% of all incidence of cancer in the USA. The incidence ratio of developing multiple primary cancers (MPCs) in female cancer survivors is 1. Read More

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http://dx.doi.org/10.7759/cureus.6954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067516PMC
February 2020

[Primary skull base chondrosarcoma: a clinicopathological analysis].

Zhonghua Bing Li Xue Za Zhi 2020 Mar;49(3):239-243

Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

To investigate the clinicopathological features, immunophenotype, molecular characteristics and differential diagnosis of primary skull base chondrosarcoma. Nine cases of primary skull base chondrosarcoma were collected at the First Affiliated Hospital of Fujian Medical University, from January 2006 to June 2019, reviewed for the clinical and radiologic data and morphologic features, immunophenotype and molecular characteristics. Among all the 9 cases, six were male, three were frmale, with average age 47 years, and median age 47 years; five cases were WHO gradeⅠ, and four were WHO grade Ⅱ. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.03.006DOI Listing

Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature.

BMC Med Genet 2020 03 14;21(1):52. Epub 2020 Mar 14.

Section of General Surgery and Gastrointestinal Surgery, Department of Surgery I, Faculdade de Medicina do ABC, Avenida Lauro Gomes, 2000, Santo André/São Paulo, CEP 09060-870, Brazil.

Background: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis characterized by benign growth of the hair follicles, the presence of pulmonary cysts, spontaneous pneumothorax, and bilateral renal tumors that are usually hybrid oncocytic or multifocal chromophobe renal cell carcinoma. The diagnosis is confirmed by the presence of a pathogenic variant in the tumor suppressor folliculin (FLCN) gene mapped at 17p11.2. Read More

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http://dx.doi.org/10.1186/s12881-020-0991-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071710PMC

Glioma Migration Through the Corpus Callosum and the Brainstem Detected by Diffusion and Magnetic Resonance Imaging: Initial Findings.

Front Hum Neurosci 2019 25;13:472. Epub 2020 Feb 25.

Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

: Glioma cell infiltration, in which the glioma tumor cells spread long distances from the primary location using white matter (WM) or blood vessels, is known as a significant challenge for surgery or localized chemotherapy and radiation therapy. Following the World Health Organization (WHO), the glioma grading system ranges from stages I to IV, in which lower-grade gliomas represent benign tumors, and higher grade gliomas are considered the most malignant. : We gathered magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data for seven patients with right precentral gyrus-located tumors and six age- and sex-matched healthy subjects for analysis. Read More

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http://dx.doi.org/10.3389/fnhum.2019.00472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052521PMC
February 2020
2.895 Impact Factor

Soft Tissue Special Issue: Chondroid Neoplasms of the Skull.

Head Neck Pathol 2020 Mar 16;14(1):83-96. Epub 2020 Jan 16.

Division of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital/University of Ottawa, 501 Smyth Rd, 4th Floor CCW, Room 4250, Ottawa, ON, K1H 8L6, Canada.

Clinically, radiologically, and pathologically, chondroid neoplasms of the skull can be diagnostically challenging due to overlapping features in each of these domains. Compounding the problem for the pathologist, there is also significant morphologic, immunophenotypic, and molecular genetic overlap between benign and malignant cartilaginous lesions, and the majority of these lesions are encountered quite rarely in routine surgical pathology practice. Each of these factors contribute to the diagnostic difficulty posed by these lesions, highlighting the importance of radiologic-pathologic correlation in the diagnosis. Read More

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http://dx.doi.org/10.1007/s12105-019-01091-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021846PMC

Peri-operative prognostic factors for primary skull base chordomas: results from a single-center cohort.

Acta Neurochir (Wien) 2020 Jan 16. Epub 2020 Jan 16.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.

Background: Skull base chordomas (SBC) are rare malignant tumors and few factors have been found to be reliable markers for clinical decision making and survival prognostication. The aim of the present work was to identify specific prognostic factors potentially useful for the management of SBC patients.

Methods: A retrospective review of all the patients diagnosed and treated for SBC at the Fondazione IRCCS Istituto Neurologico "Carlo Besta" between January 1992 and December 2017 has been performed. Read More

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http://dx.doi.org/10.1007/s00701-020-04219-7DOI Listing
January 2020
1.788 Impact Factor

[Primary Ewing's sarcoma of the temporal bone: a rare case].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1105-1108

Ewing's sarcoma is a malignant, round cell tumor arising from the bones and primarily affecting children and adolescent. Involvement of the skull bones is rarely reported, constituting 1%-6% of the total Ewing's sarcoma cases. We describe a 33 years old male patient having Ewing sarcoma of the mastoid and petrous parts of temporal bone, whose clinical presentation mimicked mastoiditis with facial nerve palsy. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.024DOI Listing
November 2019

[From bench to bedside for new treatment paradigms in chordomas: An update].

Bull Cancer 2020 Jan 24;107(1):129-135. Epub 2019 Dec 24.

Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108, bis avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France. Electronic address:

Chordomas are rare malignant tumours, which typically occur in the axial skeleton and skull base. They arise from embryonic remnants of the notochord. They constitute less than 5 % of primary bone tumours. Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.10.008DOI Listing
January 2020
0.635 Impact Factor

[Results of surgical treatment of skull-base primary malignant tumors with intracranial invasion].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(5):31-43

Burdenko Neurosurgical Center, Moscow, Russia.

Objective: Analysis of factors affecting life expectancy at patients with primary malignant tumors of anterior and middle parts of the skull base with intracranial invasion.

Material And Methods: 139 patients (47 women and 92 men) with primary malignant tumors of the anterior and middle parts of the skull base with intracranial invasion (stage T4 according to TNM classification or stage C according to Kadish classification for estesioneuroblast ) were treated at the NMRCN Burdenko for the period from 2004 till 2018. The study was conducted by the method of total sampling. Read More

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http://dx.doi.org/10.17116/neiro20198305131DOI Listing
January 2020

Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature.

Allergy Rhinol (Providence) 2019 Jan-Dec;10:2152656719889030. Epub 2019 Nov 20.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx.

Methods: A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Read More

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http://dx.doi.org/10.1177/2152656719889030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883668PMC
November 2019

Primary diffuse large B-cell lymphoma of mandible masquerading as a toothache.

Quintessence Int 2020 ;51(1):50-55

Diffuse large B-cell lymphoma is an aggressive, fast-growing form of non-Hodgkin disease with rare manifestation in mandible as a primary site. Absence of pathognomonic features in this localization often leads to misdiagnosis as an odontogenic process or its delayed diagnosis. The present case report is of a patient in whom non-odontogenic jaw pain mimicked a toothache prompting multiple dental interventions before persistence of pain and atypical findings led to consideration of a primary malignant etiology. Read More

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http://dx.doi.org/10.3290/j.qi.a43666DOI Listing
December 2019

Unusual metastatic presentations of a primary right parapharyngeal acinic cell adenocarcinoma.

Int J Oral Maxillofac Surg 2020 May 25;49(5):564-568. Epub 2019 Oct 25.

Discipline of Oral Maxillofacial Surgery, Faculty of Dentistry, National University Centre for Oral Health, Singapore. Electronic address:

Acinic cell adenocarcinoma (ACA) is a malignant epithelial neoplasm of the salivary glands. The patient reported herein presented with an unusual case of a metastatic ACA originating from the right parapharyngeal region, which eventually metastasized to the ipsilateral cavernous sinus and the contralateral mandibular ramus. The trigeminal nerve may have served as a channel for the spread of the cancer from the right parapharyngeal region to the cavernous sinus, and subsequently to the left mandibular ramus. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.09.012DOI Listing

Denosumab Therapy Obscures Histological Features of Giant Cell Tumor of Bone.

J Neuropathol Exp Neurol 2019 12;78(12):1171-1173

Departments of Pathology, Neurology and Neurosurgery, University of Colorado, Aurora, Colorado.

Giant cell tumor (GCT) of bone is a locally aggressive tumor with low metastatic potential, usually originating in long bones. Numerous spinal examples have been reported and thus GCTs can be encountered by neuropathologists. We describe a 69-year-old man with more than a 10-year history of GCT primary to the femur that had recently metastasized to the occipital skull bone. Read More

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http://dx.doi.org/10.1093/jnen/nlz100DOI Listing
December 2019
1 Read

Primary Ewing's sarcoma of the temporal bone: a rare entity and review of the literature.

BMJ Case Rep 2019 Oct 23;12(10). Epub 2019 Oct 23.

Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Ewing's sarcoma (ES) is the second most common malignant primary bone tumour in children and adolescents. It primarily affects the diaphysis of long bones and pelvis. ES arising from temporal bone is extremely rare. Read More

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http://dx.doi.org/10.1136/bcr-2019-230768DOI Listing
October 2019

[Malignant tumors of the skull base].

Radiologe 2019 Dec;59(12):1064-1070

Abteilung für diagnostische und interventionelle Radiologie, Klinikum rechts der Isar, München, Deutschland.

Malignant skull base tumors consist of a heterogeneous group of malignancies that can be divided into primary and secondary (metastatic) skull base tumors. In addition, according their anatomical location, they can be further divided into tumors of the anterior, middle, or posterior cranial fossa. Although malignant skull base tumors do not rigorously respect anatomical borders, their anatomical occurrence can potentially be helpful for possible differential diagnosis. Read More

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http://dx.doi.org/10.1007/s00117-019-00600-5DOI Listing
December 2019
1 Read

Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations.

Acta Histochem 2019 Nov 27;121(8):151448. Epub 2019 Sep 27.

Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel-Aviv University, Israel; Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Aim: To perform clinico-pathological characterization of a large series of oral metastases, collected from 3 main medical centers in Israel and compare findings to data on frequency of primary cancer types in the population.

Materials: Pathology archives were searched for cases of metastatic tumors to the oral soft tissues and jawbones, 1990 - 2016. Metastases to the skin of face or to major salivary glands have been excluded. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151448DOI Listing
November 2019
2 Reads

Is Regional Lymph Node Metastasis of Head and Neck Paraganglioma a Sign of Aggressive Clinical Behavior: A Clinical/Pathologic Review.

Ear Nose Throat J 2019 Sep 29:145561319863373. Epub 2019 Sep 29.

Department of Pathology, Rush University, Chicago, IL, USA.

Background: Head and neck paraganglioma is a rare neoplasm of the paraganglia. It accounts for <1% of all head and neck tumors. It usually has benign clinical course; however, malignant paraganglioma can only be diagnosed by showing metastatic disease. Read More

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http://dx.doi.org/10.1177/0145561319863373DOI Listing
September 2019
2 Reads
0.881 Impact Factor

Endoscopic Resection of Pediatric Skull Base Tumors: An Evidence-Based Review.

J Neurol Surg B Skull Base 2019 Oct 11;80(5):527-539. Epub 2018 Dec 11.

Department of Otolaryngology - Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

 To perform a systematic review examining experiences with endoscopic resection of skull base lesions in the pediatric population, with a focus on outcomes, recurrence, and surgical morbidities.  PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases were evaluated. Studies were assessed for level of evidence. Read More

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http://dx.doi.org/10.1055/s-0038-1676305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748853PMC
October 2019
6 Reads

Primary osteosarcoma of the skull in teenager.

BMJ Case Rep 2019 Sep 16;12(9). Epub 2019 Sep 16.

Department of Pathology, Rebagliati Hospital, Lima, Peru.

Osteosarcoma of the skull is a rare primary malignant bone tumour in children, representing 1-2% of all cranial tumours. We describe a case of a 17-year-old adolescent with chondroblastic osteosarcoma of the parietal-occipital bone and no distant metastases at presentation treated with neoadjuvant chemotherapy, surgery and, later, concurrent chemoradiotherapy. The patient suffered progressive disease and died 15 months after diagnosis. Read More

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http://dx.doi.org/10.1136/bcr-2019-229585DOI Listing
September 2019
1 Read

Challenges threaten, opportunity awaits hyperbaric medicine and the head and neck cancer patient.

Authors:
Richard Clarke

Undersea Hyperb Med 2019 Jun-Jul-Aug - Third Quarter;46(4):385-397

National Baromedical Services, Columbia, South Carolina, U.S.

Over the past four decades, hyperbaric oxygen (HBO2) therapy has played a prominent role in both the prevention and treatment of mandibular osteoradionecrosis (ORN). It has done so on the strength of laboratory observations and clinical reports, yet only limited efficacy data. This dual role has come under increasing scrutiny in the modern radiotherapy (RT) and surgical eras. Read More

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November 2019
2 Reads

Emerging Therapeutic Targets in Chordomas: A Review of the Literature in the Genomic Era.

Neurosurgery 2020 02;86(2):E118-E123

Department of Neurosurgery, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York.

Chordomas are rare primary malignant tumors of the bones that occur along the skull base, spine, and sacrum. Long-term survival and neurological outcome continue to be challenging with continued low percentages of long-term survival. Recent studies have used genome, exome, transcriptome, and proteome sequencing to assess the mutational profile of chordomas. Read More

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http://dx.doi.org/10.1093/neuros/nyz342DOI Listing
February 2020
2 Reads

Primary Leiomyosarcoma of the Mandible: Posttreatment Malocclusion Treated with an Overpartial Mandibular Resection Prosthesis.

Int J Prosthodont 2019 Sep/Oct;32(5):448-450

Leiomyosarcoma is a rare malignant condition occurring in the maxillofacial region in which the mandible may be affected. Management of this tumor in the mandible may include segmental mandibulectomy, osteocutaneous fibula free-flap reconstruction, endosseous implants, and postoperative radiotherapy. Posttreatment malocclusion can be managed with an overpartial mandibular resection prosthesis. Read More

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http://dx.doi.org/10.11607/ijp.6202DOI Listing
October 2019
1 Read

Orbital Exenteration: A 23-year Report.

Korean J Ophthalmol 2019 Aug;33(4):366-370

Ophthalmic Plastic and Reconstructive Surgery Unit, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Orbital exenteration is a psychologically and anatomically disfiguring procedure which indicated in some patients with malignant or progressive diseases of orbital and periorbital area. In this study, we reviewed 176 patients that underwent orbital exenteration.

Methods: This was a retrospective study of medical records from all patients who underwent orbital exenteration from March 1991 to March 2014 in oculoplastic department at an eye care center. Read More

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http://dx.doi.org/10.3341/kjo.2018.0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685828PMC
August 2019
2 Reads

Primary malignant epithelioid and rhabdoid tumor of bone harboring ZNF532-NUTM1 fusion: the expanding NUT cancer family.

Genes Chromosomes Cancer 2019 11 30;58(11):809-814. Epub 2019 Jul 30.

Department of Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

NUTM1 gene rearrangement is the genetic hallmark of NUT carcinoma, an aggressive tumor that most commonly affects the thoracic and head and neck regions and often exhibits squamous differentiation. The most common fusion partner gene is BRD4, followed by BRD3 and NSD3. Recently, NUTM1 gene rearrangement has been identified in rare tumors from soft tissues, intracranial locations, and other visceral organs. Read More

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http://dx.doi.org/10.1002/gcc.22785DOI Listing
November 2019
12 Reads

Melanotic Neuroectodermal Tumor of Infancy Arising in the Skull and Brain: A Systematic Review.

World Neurosurg 2019 Oct 8;130:170-178. Epub 2019 Jul 8.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented craniofacial tumor of infants. This study aimed to analyze the literature on MNTI arising from the skull and brain. A systematic literature review was performed and 91 patients reported in 78 articles were identified from 1918 to 2019. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.017DOI Listing
October 2019
3 Reads

Low-Grade Surface Osteosarcoma of the Temporal Bone in Paediatric Patients: A Case Report and Literature Review.

Clin Med Insights Pediatr 2019 26;13:1179556519855381. Epub 2019 Jun 26.

Department of Ophthalmology and Otolaryngology - Head and Neck Surgery, Université Laval, Quebec City, QC, Canada.

Purpose Of The Study: Primary osteosarcoma of the temporal bone is an exceedingly rare pathology in the paediatric population. As of now, only 3 cases have been reported in the English literature. We describe the additional case of a 16-year-old girl with an osteosarcoma of the mastoid bone. Read More

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http://dx.doi.org/10.1177/1179556519855381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595646PMC
June 2019
11 Reads

Jugular Foramen Metastasis from Lung Cancer: A Case of "A Mass without His Syndrome".

J Int Adv Otol 2019 Dec;15(3):469-471

Department of Medicine and Surgery, Unit of Otolaryngology and Otoneurosurgery, University-Hospital of Parma, Parma, Italy.

Jugular foramen (JF) metastasis is rare and often presents as JF syndrome. A 73-year-old male complained of left-sided mastoid pain that irradiated to the neck since the past 3 months. Onset of facial nerve (FN) palsy and persistence of the symptomatology despite corticosteroid therapy demanded radiologic evaluation. Read More

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http://dx.doi.org/10.5152/iao.2019.6540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937181PMC
December 2019
1 Read

Skull Base Enchondroma and Chondrosarcoma in Ollier Disease and Maffucci Syndrome.

World Neurosurg 2019 Oct 22;130:e356-e361. Epub 2019 Jun 22.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Maffucci syndrome (MS) and Ollier disease (OD) are rare diseases characterized by multiple benign enchondromas. The incidence of skull base (SB) enchondromas and the risk of malignant transformation remain unknown. Most SB lesions are asymptomatic, and surgical resection carries significant morbidity. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.06.087DOI Listing
October 2019
15 Reads

Chondrosarcoma of right big toe with metastases to left orbital and left infra temporal region.

J Pak Med Assoc 2019 Jun;69(6):896-898

Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Karachi.

To report a case of chondrosarcoma of right big toe with left orbital and left infra temporal metastases. Chondrosarcoma is the second most frequent primary malignant tumour of the bone. A 56 year old man had history of trauma on his right big toe, which was amputated and the biopsy in 2011 at Sindh Institute of Urology and Transplantation (SIUT) revealed chondrosarcoma with clear margins. Read More

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June 2019
8 Reads

Clinical Application of Temporary External Fixator for Immediate Mandibular Reconstruction.

J Craniofac Surg 2019 Jun;30(4):e337-e342

Department of Oral & Maxillofacial-Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Immediate mandibular reconstruction is always necessary for the patients receiving segmental mandibulectomy to recover the facial contour and function of occlusion. When 3D modeling is unavailable, temporary external fixator is necessary to maintain the occlusion relationship and facial contour. In this study, we introduce the clinical application of temporary external fixator for immediate mandibular reconstruction in patients receiving segmental mandibulectomy, which consists of 2 anchor claws, 2 all-round retentive arms, and 1 central locking structure. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005303DOI Listing
June 2019
7 Reads

The Epigenomics of Pituitary Adenoma.

Front Endocrinol (Lausanne) 2019 14;10:290. Epub 2019 May 14.

Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant. The cellular pathways that drive transformation in pituitary neoplasms are poorly characterized, and current classification methods are not reliable correlates of clinical behavior. Novel techniques in epigenetics, the study of alterations in gene expression without changes to the genetic code, provide a new dimension to characterize tumors, and may hold implications for prognostication and management. Read More

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http://dx.doi.org/10.3389/fendo.2019.00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527758PMC
May 2019
19 Reads

Gamma Knife Radiosurgery and Immunotherapy as Primary Treatment for a Malignant Tumor of the Cranial Base Beginning as Lentigo Maligna: A Case Report.

Pract Radiat Oncol 2019 Nov 23;9(6):e608-e612. Epub 2019 May 23.

Department of Neurosurgery, New York University School of Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2019.05.010DOI Listing
November 2019
5 Reads

Overexpression of the phospholipase A2 group V gene in glioma tumors is associated with poor patient prognosis.

Cancer Manag Res 2019 11;11:3139-3152. Epub 2019 Apr 11.

Department of Neurosurgery, Xiangya Hospital, Central-South University, Changsha, Hunan, People's Republic of China.

Gliomas are the most common primary malignant neoplasms of the central nervous system. Secreted phospholipases A2 (sPLA2s) are known to play an important role in various physiological processes, including bioactive lipid production, defense mechanisms, and cell signaling. However, their roles and clinical importance in gliomas remain unclear. Read More

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http://dx.doi.org/10.2147/CMAR.S199207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489671PMC
April 2019
15 Reads

Aggressive Ciliary Body Adenocarcinoma with Bilateral Lung Metastases: Histological, Molecular, Genetic and Clinical Aspects.

Ocul Oncol Pathol 2019 Feb 7;5(2):79-84. Epub 2018 May 7.

Sheffield Ocular Oncology Service, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Purpose Of The Study: To describe the clinical and histopathological features of an aggressive ciliary body adenocarcinoma with pulmonary metastases and skull base spread.

Procedures And Results: A 45-year-old female patient presented with a post-traumatic phthisical eye that was eviscerated. This showed an unexpected carcinoma (positive for cytokeratins and melanocytic markers), the histological differential diagnosis for which included a primary ciliary body adenocarcinoma or a metastasis. Read More

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http://dx.doi.org/10.1159/000487805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422130PMC
February 2019
28 Reads

Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Oral & Maxillofacial Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Mucoepidermoid carcinoma (MEC) can be rarely found as a primarily intraosseous lesion and mistaken for other intraosseous or odontogenic pathology. A 65-year-old man had a poorly defined radiolucency distal to the left mandibular second molar root. Periapical radiographs demonstrated a minor radiolucency from 2. Read More

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http://dx.doi.org/10.1136/bcr-2018-224612DOI Listing
April 2019
27 Reads

Post-carbon-ion radiotherapy vertebral pathological fractures in upper cervical primary malignant spinal tumors treated by occipito-cervical fusion.

Arch Orthop Trauma Surg 2019 Nov 3;139(11):1525-1531. Epub 2019 Apr 3.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Purpose: To describe the characteristic features of post-carbon-ion radiotherapy (CIRT) vertebral pathological fractures (VPFs) in upper cervical primary malignant spinal tumors (PMSTs) treated by occipito-cervical (OC) fusion.

Methods: OC fusion was performed for three consecutive patients with post-CIRT VPFs. The clinical results and imaging findings, including bone single-photon emission computed tomography (SPECT)/CT were prospectively collected. Read More

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http://dx.doi.org/10.1007/s00402-019-03183-xDOI Listing
November 2019
5 Reads

Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review.

Ren Fail 2019 Nov;41(1):98-103

a Department of Urology , The First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi Province , China.

As an extremely rare malignant neoplasm, only 12 mesenchymal chondrosarcoma (MC) arising in kidney have been reported to date. Herein, we reported a case of primary renal MC resected with robot assistance, which has not been reported before. According to the cases reported in English literature, we analyzed the characteristics of this rare malignancy and systematically review its treatment. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1583111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442158PMC
November 2019
10 Reads

Intra-Extracranial Primary Clear Cell Sarcoma: The First Report and Review of the Literature.

World Neurosurg 2019 Jun 14;126:e1140-e1146. Epub 2019 Mar 14.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Background: Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor with poor prognosis owing to metastasis and insensitive response to chemotherapy and radiotherapy.

Methods: We first searched PubMed and Embase using the terms "clear cell sarcoma," "malignant melanoma of soft tissue," "head," and "neck." In the 15 articles selected for literature review, only 27% (4/15) of patients were diagnosed with primary CCS of the head. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.216DOI Listing
June 2019
29 Reads

Fluorescence imaging of meningioma cells with somatostatin receptor ligands: an in vitro study.

Acta Neurochir (Wien) 2019 05 15;161(5):1017-1024. Epub 2019 Mar 15.

Klinik für Neurochirurgie, Universitätsklinikum des Saarlandes, 66421, Homburg, Saar, Germany.

Background: The use of five-aminolevulinic acid (5-ALA) in the staining of malignant glioma cells has significantly improved intraoperative radicality in the resection of gliomas in the last decade. Currently, there is no comparable selective fluorescent substance available for meningiomas. There is however a demand for intraoperative fluorescent identification of, e. Read More

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http://dx.doi.org/10.1007/s00701-019-03872-xDOI Listing
May 2019
2 Reads

Melanotic neuroectodermal tumour of infancy: Refining the surgical approach.

Int J Oral Maxillofac Surg 2019 Oct 11;48(10):1307-1312. Epub 2019 Mar 11.

Great Ormond Street Hospital, London, UK.

Melanotic neuroectodermal tumours of infancy (MNTI) are particularly rare and although predominantly benign, are infiltrative and locally aggressive. Presenting in the first year of life, prompt diagnosis and effective management are critical in minimizing morbidity and the risk of recurrence. A retrospective review of 11 MNTI managed at Great Ormond Street Hospital (GOSH) from 2000 to 2017 was undertaken. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.02.011DOI Listing
October 2019
10 Reads

[Extirpation of primary malignancies in the pterygopalatine and infratemporal fossa via modified maxillary swing approach].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Mar;54(3):194-197

Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.

Five patients with primary malignancies in the pterygopalatine fossa (PPF) and infra temporal fossa (ITF) were enrolled in this retrospective study between January 2012 and January 2018. After malignancies proven by biopsy and evaluation with CT and MRI scan, all patients received modified maxillary swing (MMS) approach for extirpation of malignant tumors in the PPF and ITF under general anesthesia. En bloc resection with wide surgical margins was successfully performed in all cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.03.009DOI Listing
March 2019
13 Reads

More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.

Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7.

Department of Nuclear Medicine and PET/CT, Evangelismos General Hospital, Ypsilantou 45-47, PC 106 76, Athens, Greece.

Prostate cancer (PCa) is the most common solid cancer affecting men worldwide. Serum prostate-specific antigen (PSA) is at present the most commonly used biomarker for PCa screening, as well as a reliable marker of disease recurrence after initial treatment. Bone metastases (BM) are present in advanced stages of the disease. Read More

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http://dx.doi.org/10.1967/s002449910952DOI Listing
July 2019
30 Reads

Alveolar soft part sarcoma metastatic to the breast: a case report.

BMC Surg 2019 Mar 4;19(1):30. Epub 2019 Mar 4.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Alveolar soft part sarcoma (ASPS) is an extremely rare neoplasm that tends to occur in the lower limbs of children and adolescents. Metastatic breast tumors constitute 0.5-2. Read More

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http://dx.doi.org/10.1186/s12893-019-0494-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399980PMC
March 2019
25 Reads