890 results match your criteria Primary Malignant Skull Tumors


Paraganglioma with highly malignant potential involving the rib - Case report and review of the literature.

Radiol Case Rep 2021 Jul 21;16(7):1845-1850. Epub 2021 May 21.

Department of Diagnostic Radiology, University of Manitoba, Room O2055, St Boniface General Hospital, 409 Tache Avenue, Winnipeg, MB R2H 2A6, Canada.

Paragangliomas are rare neuroendocrine tumors arising from paraganglion cells in sympathetic or parasympathetic chains, which may develop in the abdomen, chest, skull base, and neck. As paragangliomas have a wide range of imaging features, the diagnosis often requires tissue sampling. We present a unique case of a paraganglioma which originally presented as a rib tumor. Read More

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Skull Base Primary Ewing Sarcoma: A Radiological Experience of a Rare Disease in an Atypical Location.

Am J Case Rep 2021 Jun 5;22:e930384. Epub 2021 Jun 5.

Department of Radiology, School of Medical Sciences, University of Science Malaysia, Kota Bharu, Malaysia.

BACKGROUND Ewing sarcoma and primitive neuroectodermal tumor are rare tumors grouped under the spectrum of the Ewing sarcoma family of tumors. These highly malignant tumors involve the bones and commonly occur in children. Ewing sarcoma of the skull bone accounts for only 1% of all Ewing sarcomas, with primary skull base Ewing sarcoma occurring in less than 1% of cases. Read More

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A rare malignant periurethral carcinosarcoma with aggressive behavior: A case treated with a multimodal treatment approach.

Urol Case Rep 2021 Sep 29;38:101699. Epub 2021 Apr 29.

Department of Urology, Chungnam National University Sejong Hospital, Chungnam National University, Sejong, South Korea.

Carcinosarcoma is an aggressive tumor that can develop in any organ but is rarely observed in the urinary tract. Given the radioresistant nature of carcinosarcoma and the rapidly regrowing tumor after primary surgery, carcinosarcomas that developed in the body showed poor outcomes regardless of aggressive management. However, the specific optimal treatment for periurethral carcinosarcoma remains unknown. Read More

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September 2021

Difficulties encountered in the diagnosis of primary esophageal malignant melanoma by 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a case report.

Ann Palliat Med 2021 Apr;10(4):4975-4981

Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Primary malignant melanoma of the gastrointestinal mucosa is a rare tumor. Here, we report a case of a 60-year-old female patient with esophageal malignant melanoma. Combined with the related literature, the clinical manifestations, imaging, histopathological and immunohistochemical features of primary esophageal malignant melanoma were observed and analyzed. Read More

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Sinonasal Renal Cell-Like Adenocarcinoma.

Cureus 2021 Apr 4;13(4):e14285. Epub 2021 Apr 4.

Otolaryngology - Head and Neck Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a newly defined, rare malignant tumor of the nasal cavity. The clinical course and response to treatment remain uncertain. The purpose of this study is to report a new case of SNRCLA and review the literature to determine clinical characteristics, treatment options, and outcomes. Read More

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Sinonasal Extramedullary Plasmacytoma With Rare Osteolytic Lesions.

Cureus 2021 Mar 31;13(3):e14220. Epub 2021 Mar 31.

Orthopedics, General Hospital of Patras, Patras, GRC.

Plasmacytomas are malignant tumors characterized by abnormal monoclonal proliferation of plasma cells. They originate either from bone or soft tissue and could be primary or a part of a systemic process during the course of multiple myeloma. Extramedullary plasmacytomas (EPs) in the sinonasal tract or nasopharynx are rare and mostly presented as case reports. Read More

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[Primary malignant peripheral nerve sheath tumor in left orbit: a case report].

Zhonghua Zhong Liu Za Zhi 2021 04;43(4):509-510

Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

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[Analysis of efficacy of coblation assisted endoscope system for the treatment of parapharyngeal space tumors with transoral approach].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):204-208

Department of Otorhinolaryngology,the First Affiliated Hospital,Nanjing Medical University,Nanjing,210029,China.

To summarize and analyze the feasibility, safety and efficacy of parapharyngeal space surgery assisted by coblation and endoscopic system with transoral approach. The data of 20 patients with parapharyngeal space tumors were retrospectively analyzed. All the patients underwent CT and/or MRI examination before surgery, and all underwent transoral approach assisted by coblation and endoscopic systems. Read More

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Primary Malignant Orbital Tumors.

J Neurol Surg B Skull Base 2021 Feb 18;82(1):81-90. Epub 2021 Feb 18.

Stanford Department of Ophthalmology, Byers Eye Institute, Palo Alto, California, United States.

 Primary orbital malignancy is rare. Awareness of the characteristic clinical and imaging features is imperative for timely identification and management. Surgery remains an important diagnostic and treatment modality for primary orbital malignancy, but determining the optimal surgical approach can be challenging. Read More

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February 2021

Primary thymic atypical carcinoid with rare multiple bone metastasis: A case report and literature review.

Mol Clin Oncol 2021 Apr 25;14(4):78. Epub 2021 Feb 25.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Primary thymic atypical carcinoid (TAC) is a type of extremely rare neuroendocrine tumor. Approximately one-third of patients with TAC tumors are asymptomatic, and no treatments of TAC have been rigorously tested in multicenter clinical trials. To date, there has been no previous case report of TACs with multiple skull metastases. Read More

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Primary yolk sac tumor of pterygopalatine fossa with loss of vision: A case report.

Medicine (Baltimore) 2021 Feb;100(8):e24916

Department of Emergency Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine; Research Institute of Emergency Medicine, Zhejiang University, Hangzhou, China.

Introduction: Primary yolk sac tumor (YST) is an infrequently-diagnosed malignant extragonadal germ cell tumors. It is likely to recur locally and may present with widespread metastases once diagnosed. Primary YST of the head is uncommon but can cause severe complications, such as loss of vision once the tumor mass invades the optic nerve. Read More

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February 2021

Secondary undifferentiated pleomorphic sarcoma of the mandible in a HIV patient who underwent radiotherapy for oral carcinoma.

Spec Care Dentist 2021 May 5;41(3):417-422. Epub 2021 Feb 5.

ASST Santi Paolo e Carlo, Presidio Ospedaliero San Paolo, Odontostomatologia II Clinical Unit, Milan, Italy.

Undifferentiated pleomorphic sarcoma (UPS), also defined malignant fibrous histiocytoma (MFH), is one of the most common sarcomas affecting soft tissues in adults, but it can also arise as a primary tumor in bone. UPS is extremely uncommon in the lower jaw and presents very aggressive clinical behavior with high rate of local recurrences and frequent metastases. Secondary UPS are even rarer than primary forms, and they are usually closely associated with local trauma or radiotherapy. Read More

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Temporal bone primary inverted papilloma - Case Report and review of the literature.

Laryngorhinootologie 2021 02 1;100(2):99-103. Epub 2021 Feb 1.

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Medizinische Hochschule Hannover, Germany.

Inverted papilloma of middle ear is an extremely rare lesion of the respiratory epithelium that normally occurs in the nasal cavity and paranasal sinuses. So far less than 17 cases were described in literature. A 45-year-old patient was admitted in our Department with hearing loss, otorrhea and pulsing tinnitus on the right ear. Read More

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February 2021

Recurrent inverted papilloma coexisted with skull base lymphoma: A case report.

World J Clin Cases 2021 Jan;9(2):516-520

Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Background: Inverted papilloma is an uncommon neoplasm in the nasal cavity. It is a histologically benign tumor, but has a high recurrence and local invasion rate. In addition, nasal or skull base lymphoma is another rare neoplasm. Read More

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January 2021

Transmandibular Approach in Head and Neck Oncological Surgery.

Chin J Dent Res 2020 ;23(4):257-264

Objective: To evaluate the advantages and disadvantages of the transmandibular approach to the posterior area of the maxilla, oropharyngeal region and the hypopharynx in head and neck surgery. Methods: A series of 42 patients who underwent a lip-split mandibulotomy procedure to access malignant tumours affecting deep areas of the head and neck region between 2008 and 2018 in the Department of Oral and Maxillofacial Surgery at the Ramón y Cajal University Hospital (Madrid, Spain) were retrospectively reviewed. The diagnosis and operations data of the patients were collected and analysed. Read More

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January 2021

A nationwide population-based study on overall survival after meningioma surgery.

Cancer Epidemiol 2021 02 24;70:101875. Epub 2020 Dec 24.

INSERM U1153, Statistic and Epidemiologic Research Center Sorbonne Paris Cité (CRESS), ECSTRRA Team, Université de Paris, France.

Background: There are very few nationwide studies on meningioma outcome, the most common primary intracranial tumour.

Methods: We processed the French Système National des Données de Santé (SNDS) database using an algorithm combining the type of surgical procedure and the International Classification of Diseases to retrieve all cases of meningiomas operated between 2007 and 2017. A survival analysis was performed. Read More

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February 2021

Successful treatment of non-midline primary malignant germ cell tumors with yolk sac components in neonates: report of 2 cases.

J Neurosurg Pediatr 2020 Oct 30:1-5. Epub 2020 Oct 30.

3Division of Neurosurgery, Department of Pediatric Surgery, Montreal Children's Hospital, McGill University Health Centre, Montreal.

Here, the authors present 2 cases of nongerminomatous germ cell tumor (NGGCT): a neonate with a mixed malignant germ cell tumor, 5% yolk sac tumor (YST) and 95% immature teratoma components, originating from the right mesial temporal lobe; and a 2-month-old infant with a pure YST originating from the left middle cranial fossa. These tumors with yolk sac components, which are thought to have a poor prognosis, were successfully treated with complete tumor resection alone and subtotal tumor resection with chemotherapy, respectively. Event-free survival exceeds 5 years for each patient even though neither received radiotherapy. Read More

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October 2020

Facial nerve management in patients with malignant skull base tumors.

J Neurooncol 2020 Dec 28;150(3):493-500. Epub 2020 Oct 28.

Facial Paralysis Institute, Center for Advanced Facial Plastic Surgery, Beverly Hills, CA, USA.

Introduction: The course of the facial nerve through the cerebellopontine angle, temporal bone, and parotid gland puts the nerve at risk in cases of malignancy. In contrast to Bell's palsy, which presents with acute facial paralysis, malignancies cause gradual or fluctuating weakness.

Methods: We review malignancies affecting the facial nerve, including those involving the temporal bone, parotid gland, and cerebellopontine angle, in addition to metastatic disease. Read More

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December 2020

Primary orbital extraskeletal osteosarcoma and review of literature.

BMC Ophthalmol 2020 Oct 22;20(1):425. Epub 2020 Oct 22.

Tianjin Eye Hospital, Tianjin Eye Institute, NO.4 Gansu Road, Heping District, Tianjin, 300020, China.

Background: Extraskeletal osteosarcoma is a malignant tumour composed of an osteoid and/or cartilaginous matrix; it arises in soft tissues without connection to the skeleton, and to our knowledge, this type of tumour is extremely rare.

Case Presentation: The present study reports a 57-year-old man with primary orbital extraskeletal osteosarcoma who presented with a history of painful swelling in the left orbit that had occurred for 11 months. Imaging of the orbit showed an atypical, well-defined heterogeneous mass attached to the posterior globe of the left orbit. Read More

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October 2020

Imaging of Mixed and Radiopaque Jaw Lesions.

Semin Musculoskelet Radiol 2020 Oct 9;24(5):558-569. Epub 2020 Oct 9.

Department of Radiology, GZA Hospitals, Antwerp, Belgium.

Radiopaque lesions and lesions of mixed density are less frequent than radiolucent lesions of the jawbones. They comprise a spectrum of odontogenic and non-odontogenic lesions. The latter group includes inherited and developmental disorders, osteomyelitis, and benign and malignant primary bone tumors and metastases. Read More

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October 2020

Late simultaneous carcinomatous meningitis, temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting with mono-symptomatic vertigo - a clinico-pathological case reporT.

Ideggyogy Sz 2020 Sep;73(9-10):354-360

Department of Otorhinolaryngology and Head-Neck Surgery, University of Szeged, Szeged.

Background And Purpose: Although vertigo is one of the most common complaints, intracranial malignant tumors rarely cause sudden asymmetry between the tone of the vestibular peripheries masquerading as a peripheral-like disorder. Here we report a case of simultaneous temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting as acute unilateral vestibular syndrome, due to the reawakening of a primary gastric signet ring cell carcinoma. Purpose - Our objective was to identify those pathophysiological steps that may explain the complex process of tumor reawakening, dissemination. Read More

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September 2020

LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma.

J Cell Mol Med 2020 10 11;24(20):12094-12106. Epub 2020 Sep 11.

Department of Neurosurgery, Xiangya Hospital, Central-South University, Changsha, China.

Glioma is the most common primary malignant tumour in the brain; temozolomide (TMZ) is the most prevalent chemotherapeutic drug currently used to combat this cancer. We reported previously that the long intergenic non-protein coding RNA 470 (LINC00470) is a novel prognostic biomarker for glioma and promotes the tumour growth in an intracranial transplantation mouse model. However, the effects of LINC00470 on glioma cell proliferation, invasion and TMZ chemosensitivity, as well as its molecular mechanism, remain unclear. Read More

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October 2020

A rare case of cervical metastatis of glioblastoma after cranial tumor resection: case report and review of literature.

Br J Neurosurg 2021 Jun 1;35(3):341-347. Epub 2020 Sep 1.

Department of Neurosugery, Istanbul Education and Research Hospital, Istanbul, Turkey.

Glioblastoma multiforme (GBM) is the most common and the most malignant primary intracranial tumor in adults. GBM extraneural metastases occur in only approximately 0.2-0. Read More

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Psychometric testing of the Skull Base Inventory health-related quality of life questionnaire in a multi-institutional study of patients undergoing open and endoscopic surgery.

Qual Life Res 2021 Jan 26;30(1):293-301. Epub 2020 Aug 26.

Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON, Canada.

Purpose: The skull base inventory (SBI) was developed to better assess health-related quality of life (HR-QOL) in patients with anterior and central skull base neoplasms treated by endoscopic and open approaches. The primary objective of this study was to prospectively assess the psychometric properties of the SBI.

Methods: This study is part of a multi-center study of patients undergoing endoscopic and open procedures completed between 2012 and 2018. Read More

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January 2021

[Retrospective analysis of primary parapharyngeal space tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Aug;34(8):743-747

College of Otorhinolaryngology Head and Neck Surgery,PLA General Hospital,Chinese PLA Medical School.

To explore the clinical feature and surgical treatment of patients with parapharyngeal space tumors. A retrospective review of 214 cases with parapharygeal space tumors treated. The data on clinical manifestations, imaging examinations, pathological types, surgical approach, and postoperative complications were reviewed. Read More

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Primary diffuse large B-cell lymphoma of the mandible: A case report.

Gerodontology 2020 Sep;37(3):307-311

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.

Introduction: Lymphomas are a heterogeneous group of malignant neoplasms of lymphocytes and their precursor cells. Lymphoma is seen 3.5% of all intraoral malignancies and is the second most common neoplasm after the squamous cell carcinoma in the head and neck region. Read More

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September 2020

Fulminant presentation of a SMARCB1-deficient, anterior cranial fossa tumor in adult.

Surg Neurol Int 2020 18;11:195. Epub 2020 Jul 18.

Departments of Neurosurgery, Rabin Medical Center, Petha Tiqva, Israel.

Background: Malignant atypical teratoid rhabdoid tumor (ATRT) usually develops in children. ATRTs are rare in adults, with only one case in the literature describing involvement of the anterior skull base. These primary intracranial tumors are characterized molecularly as SMARCB1 (INI1) deficient. Read More

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Treatment Options for Recurrent Anterior Skull Base Tumors.

Adv Otorhinolaryngol 2020 30;84:231-245. Epub 2020 Jul 30.

Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua, Padua, Italy.

Malignancies of the anterior skull base are rare and recur in 40-80% of treated cases, varying with substantial variance according to histology, stage at primary diagnosis, and other factors. Most recurrences manifest within 2-5 years after primary treatment, but some histologies can relapse even decades after the first presentation. Management of recurrent anterior skull base tumors is challenging and a wide variety of treatment options are available. Read More

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Squamous Cell Carcinoma and Its Variants.

Adv Otorhinolaryngol 2020 30;84:124-136. Epub 2020 Jul 30.

Department of Head and Neck Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA,

Squamous cell carcinoma (SCC) is one of the most common malignant neoplasms involving the anterior skull base, resulting from local invasion from an adjacent anatomical region. The primary sites of origin are most frequently the nasal cavity and paranasal sinuses, and less often the skin and orbit. Treatment strategies for these tumors have evolved, although management remains challenging due to the proximity to critical structures and their location at the intracranial-extracranial interface. Read More

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Fatal high-grade skull osteosarcoma 30 years following radiotherapy for Cushing's disease.

Endocrinol Diabetes Metab Case Rep 2020 Jul 5;2020. Epub 2020 Jul 5.

Department of Endocrinology and Diabetes, Blacktown Hospital, Sydney, Australia.

Summary: Cushing's disease is a rare disorder characterised by excessive cortisol production as a consequence of a corticotroph pituitary tumour. While the primary treatment is surgical resection, post-operative radiation therapy may be used in cases of ongoing inadequate hormonal control or residual or progressive structural disease. Despite improved outcomes, radiotherapy for pituitary tumours is associated with hypopituitarism, visual deficits and, rarely, secondary malignancies. Read More

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