959 results match your criteria Primary Malignant Skull Tumors

Hyperostosis in orbital rhabdomyosarcoma.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila, Philippines.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in paediatric patients and may arise as a primary orbital neoplasm. Imaging studies show a unilateral solitary orbital lesion. With larger tumours, erosion of the adjacent orbital walls is a common accompanying bony change. Read More

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Infra-Temporal and Pterygo-Palatine Fossae Tumors: A Frontier in Endoscopic Endonasal Surgery-Description of the Surgical Anatomy of the Approach and Report of Illustrative Cases.

Int J Environ Res Public Health 2022 May 25;19(11). Epub 2022 May 25.

Programma Neurochirurgia Ipofisi-Pituitary Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.

Infratemporal and pterygopalatine fossae (ITF and PPF) represent two complex paramedian skull base areas, which can be defined as jewelry boxes, containing a large number of neurovascular and osteomuscular structures of primary importance. They are in close communication with many craniofacial areas, such as nasal/paranasal sinuses, orbit, middle cranial fossa, and oral cavities. Therefore, they can be involved by tumoral, infective or inflammatory lesions spreading from these spaces. Read More

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18F-FDG PET/CT in Primary Intraosseous Squamous Cell Carcinoma.

Clin Nucl Med 2022 Jul 5;47(7):632-634. Epub 2022 Apr 5.

From the Department of Molecular Imaging, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao City, Shandong Province, China.

Abstract: Primary intraosseous squamous cell carcinoma is a highly malignant but rare tumor within jaws. We reported the 18F-FDG PET/CT findings of primary intraosseous squamous cell carcinoma of the mandible in a 42-year-old man. 18F-FDG PET/CT identified a cystic lesion in the mandible with irregular annular uptake of 18F-FDG, which has been confirmed as primary intraosseous squamous cell carcinoma pathologically. Read More

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Differential performances in lesions and radio-tracer of 18F-FDG PET/CT between multiple myeloma and unknown osteolytic metastasis.

Curr Med Imaging 2022 May 16. Epub 2022 May 16.

Shanghai Tenth People's Hospital Tongji University, Shanghai 200072, China.

Purpose To investigate the differential performances in lesions and radio-tracer of 18F-FDG PET/CT between multiple myeloma and unknown osteolytic metastasis. Methods A retrospective study was performed on 18F-FDG PET/CT imaging of 63 patients with multiple bone destructions without extraosseous primary malignant tumors. By pathological diagnosis, 20 patients were confirmed to have multiple myeloma, and 43 patients have unknown osteolytic metastasis. Read More

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Skull Base Tumor Mimics.

Neuroimaging Clin N Am 2022 May;32(2):327-344

Department of Radiology, NYU Langone Health, 222 East 41st Street, 5th Floor Radiology, New York, NY 10017, USA. Electronic address:

Many different benign and malignant processes affect the central skull base and petrous apices. Clinical evaluation and tissue sampling are difficult because of its deep location, leaving imaging assessment the primary means for lesion evaluation. Skull base lesions demonstrate a variety of confusing appearances on imaging, creating diagnostic dilemmas. Read More

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LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas.

J Neurooncol 2022 May 4;158(1):81-88. Epub 2022 May 4.

Department of Neurosurgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Purpose: Chordomas are malignant tumors that develop along the neuraxis between skull-base and sacrum. Chondrosarcomas show similarities with chordomas, yet show less malignant behavior. LIM and SH3 protein 1 (LASP1) is a cytoskeletal protein known to promote the malignant behavior of tumors. Read More

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Surgical Resection of a Third Ventricle Nongerminomatous Germ Cell Tumor: Two-Dimensional Operative Video.

World Neurosurg 2022 Jul 30;163. Epub 2022 Mar 30.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China; Neurosurgical Institute of Fudan University, Shanghai, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China; Research Unit of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery (2018RU008), Chinese Academy of Medical Sciences, Shanghai, China; Department of Neurosurgery, Fujian Campus of National Regional Medical Center, Huashan Hospital, Fudan University, Fuzhou, Fujian, China. Electronic address:

Surgical resection of a pineal tumor growing into the third ventricle is difficult owing to the complex neurovascular structures, and nongerminomatous germ cell tumor is the most common malignant tumor in pediatric patients. Removing the tumor efficiently with minimal blood loss while protecting the surrounding neurovascular structure is challenging. We present a surgical case of a 9-year-old patient with a third ventricle nongerminomatous germ cell tumor (Video). Read More

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Is There Any Relationship Between Systemic Inflammatory Markers And Meningioma Grade?

Neurol India 2022 Jan-Feb;70(1):223-230

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Systemic inflammatory markers have been found to be of value in predicting the prognosis in renal cell and gastrointestinal cancers. Recent studies in gliomas correlating with Systemic inflammatory markers (SIMS) have shown promise in predicting survival.

Objective: Meningiomas are the commonest intracranial primary brain tumors in adults. Read More

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Epidemiology of primary malignant non-osseous spinal tumors in the United States.

Spine J 2022 Mar 5. Epub 2022 Mar 5.

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, USA; Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Section of Skull Base Surgery, Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background Context: Primary malignant non-osseous spinal tumors are relatively rare and this has led to a paucity of studies specifically examining the epidemiology of malignant spinal tumors.

Purpose: To provide an updated and more comprehensive study examining the epidemiology and relative survival of these rare tumors.

Study Design/setting: Data was retrospectively acquired from the Central Brain Tumor Registry of the United States (CBTRUS). Read More

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Benign bony tumors of the paranasal sinuses, orbit, and skull base.

Am J Otolaryngol 2022 May-Jun;43(3):103404. Epub 2022 Feb 26.

Weill Cornell Medical College, Department of Otolaryngology - Head and Neck Surgery, 2315 Broadway, 3rd Floor, New York, NY 10024, United States of America. Electronic address:

Benign bony tumors of the skull base and paranasal sinuses are uncommon entities, with an overall higher incidence in males. Benign bony tumors may lead to local expansion with resultant mass effect of potentially critical structures. Some benign bony tumors may undergo malignant transformation. Read More

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Recurrent Primary Inverted Papilloma of the Mastoid with Intracranial Invasion: A 7-Year Follow-Up.

J Int Adv Otol 2022 Jan;18(1):79-83

Section of Neurosurgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia.

A 55-year-old man presented to the otolaryngology department complaining of aural fullness in his left ear after an episode of probable otitis 3 months before. magnetic resonance imaging revealed a soft tissue mass within the mastoid cavity that had destroyed the posterior wall of the middle ear with no apparent middle ear or sinonasal origin. The patient underwent a left canal wall-up tympanomastoidectomy, and the pathology report confirmed an inverted papilloma. Read More

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January 2022

[Nasal endoscopy assisting combined with transoral approach for resection of carcinoma of the palate invading nasal cavity and sinuses].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;36(3):194-197

Department of Head and Neck Surgery,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya Medical School,Central South University,Changsha,410013,China.

To explore the value of nasal endoscopy assisting combined with transoral approach in resection of the carcinoma of the palate with the nasal cavity and sinuses invaded. A retrospective analysis of 21 patients with a primary malignant tumors of the palate was performed. Preoperative nasal endoscopy and CT and MRI scan showed that the primary tumors invading the nasal cavity and sinuses in all patients or skull base with varying degrees. Read More

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Treatment Strategies for Malignancies of the External Auditory Canal.

Curr Treat Options Oncol 2022 Jan 15;23(1):43-53. Epub 2022 Feb 15.

Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Opinion Statement: Malignant tumors of the external auditory canal (EAC) are rare tumors in the head and neck. Delayed diagnosis is not uncommon because the symptoms of early tumors are nonspecific. Various surgical and oncological treatment modalities have been reported. Read More

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January 2022

Orbital metastasis: Clinical presentation and survival in a series of 11 cases.

Arch Soc Esp Oftalmol (Engl Ed) 2022 Feb 29;97(2):81-88. Epub 2020 Nov 29.

Servicio de Oftalmología, Hospital Universitario La Paz, Madrid, Spain.

Background And Objective: Orbital metastases are an uncommon condition. They may be the clinical presentation of a previously unknown malignancy. Depending on the series, the rate of orbital metastasis as a first manifestation of a malignant tumour is 20%-42%. Read More

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February 2022

Primary cutaneous apocrine carcinoma of the scalp: Two case reports and literature review.

Medicine (Baltimore) 2022 Feb;101(6):e28808

Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea.

Rationale: Apocrine carcinoma is a rare malignant sweat gland tumor that has been reported in approximately 200 cases. This tumor usually occurs in the axilla, but in rare cases, it can also develop in the scalp. In the present work, we report 2 cases of cutaneous apocrine carcinoma of the scalp. Read More

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February 2022

Primary intraosseous carcinoma in the pediatric and adolescent mandible.

World J Surg Oncol 2022 Jan 27;20(1):25. Epub 2022 Jan 27.

Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

Background: Primary intraosseous carcinoma (PIOC) is a rare malignant odontogenic tumor that predominantly occurs in males older than 50 years. PIOC can be misdiagnosed as odontogenic cyst because it occasionally shows a well-defined border on radiography. In this study, related literatures of pediatric and adolescent PIOC cases were analyzed under strict PRISMA guidelines along with an adolescent case who was provisionally misdiagnosed as an odontogenic cyst. Read More

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January 2022

Clinical manifestations of diffuse large B-cell lymphoma that exhibits initial symptoms in the maxilla and mandible: a single-center retrospective study.

BMC Oral Health 2022 01 26;22(1):20. Epub 2022 Jan 26.

Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphatic tumor; however, extranodal DLBCLs that exhibit initial symptoms in the maxilla and mandible are rare. Moreover, DLBCL is clinically classified as a moderate to highly malignant lymphatic tumor that can progress rapidly; therefore, early diagnosis is crucial. However, diagnosis is difficult as the disease causes a diverse range of clinical symptoms with no characteristic imaging findings. Read More

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January 2022

Craniovertebral junction chordomas: Case series and strategies to overcome the surgical challenge.

J Craniovertebr Junction Spine 2021 Oct-Dec;12(4):420-431. Epub 2021 Dec 11.

Department of Neuroscience "Rita Levi Montalcini", Neurosurgery Unit, University of Turin, Turin, Italy.

Introduction: Chordomas are rare and malignant primary bone tumors. Different strategies have been proposed for chordomas involving the craniovertebral junction (CVJ) compared to other locations. The impossibility to achieve en bloc excision, the impact on stability and the need for proper reconstruction make their surgical management challenging. Read More

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December 2021

[Skull base metastases with cranial nerve deficits : Clinical profile of a severe disease].

Nervenarzt 2022 Jan 13. Epub 2022 Jan 13.

Department of Radiation-Oncology, University Hospital Leipzig, Leipzig, Deutschland.

Background And Purpose: Skull base metastases are a severe complication of various malignant tumors. If cranial nerves are involved even small lesions can cause significant symptoms. Specific clinical characteristics like neurological symptoms, associated primary tumors, prognosis and optimal treatment are poorly defined and are systematically described in this article. Read More

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January 2022

Primary salivary acinar cell carcinoma of the parotid gland with parietal skull metastasis: A case report.

Asian J Surg 2022 Mar 6;45(3):926-927. Epub 2022 Jan 6.

Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241000, Anhui, China. Electronic address:

Acinar cell carcinoma of the salivary gland (AciCC) is a rare low-grade epithelial malignant tumor of the salivary gland. The primary site of the disease is often in the parotid gland, followed by the submandibular gland and small salivary gland. In the early stage of the disease, there are no obvious symptoms, most of which are slow enlargement of the mass, accompanied by local pain or discomfort, or facial paralysis involving the facial nerve. Read More

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Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression.

Clin Neuropathol 2022 Mar-Apr;41(2):74-82

Histiocytic sarcoma (HS) is a rare malignant neoplasm of macrophage-dendritic cell lineage that can occur at any site. Primary base of skull involvement is exceedingly rare. We present the case of a previously healthy 56-year-old man who complained of headaches and showed localized neurologic symptoms. Read More

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[Use of radial forearm free flap for the reconstruction of hard and soft palate].

Stomatologiia (Mosk) 2021 ;100(6):38-43

N.N. Blohin Russian Cancer Research Center, Moscow, Russia.

Objective: Improvement functional and aesthetic results of treatment patients with defects of the hard and soft palate after resections for malignant tumors.

Materials And Methods: During the period from 2014 to 2020, 30 patients underwent microsurgical reconstruction of hard and soft palate defects using a radial forearm free flap. For the primary tumor process, surgery was performed in 21 patients (70%), for relapse after chemotherapy, combined or complex treatment - in 9 patients (30%). Read More

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December 2021

MiR196a-5p in extracellular vesicles released from human nasopharyngeal carcinoma enhance the phagocytosis and secretion of microglia by targeting ROCK1.

Exp Cell Res 2022 02 21;411(2):112988. Epub 2021 Dec 21.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Liberation Avenue, Wuhan, 430030, China. Electronic address:

The microenvironment of the brain has become increasingly recognized as an essential regulator in metastatic and primary brain tumors. Recent studies demonstrate that circulating tumor-derived exosomes are critical for the brain tumor microenvironment. Nasopharyngeal carcinoma (NPC), a malignant tumor of the head and neck, often invades the skull base but infrequently extends to brain parenchyma. Read More

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February 2022

Primary malignant melanoma of mandibular gingiva: A rare case report.

J Cancer Res Ther 2021 Oct-Dec;17(6):1565-1568

Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Oral malignant melanomas are rare neoplasms of the oral cavity which present significant diagnostic ambiguity. The etiology is unclear though the stimulation of melanoblasts by genetic, epigenetic, and traumatic causes that have been proposed in etiopathogenesis. Clinically, it presents as a pigmented swelling or growth which remains asymptomatic until it advances to later stages. Read More

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February 2022

Case Report: Ocular Manifestation of Mantle Cell Lymphoma.

Optom Vis Sci 2022 02;99(2):186-189

Significance: Mantle cell lymphoma (MCL) is a rare lymphoma that can present even more rarely in the orbit. Diagnosis, differentiation, and systemic treatment with the help of an oncologist are necessary for improved prognosis. Eye care providers must be vigilant when addressing ocular findings to determine next steps. Read More

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February 2022

Rare case report and literature review of intracranial mesenchymal chondrosarcoma.

Ann Palliat Med 2021 Nov;10(11):12012-12017

First Ward of Cancer Center, People's Hospital of Henan Province, Zhengzhou, China.

Intracranial mesenchymal chondrosarcoma (IMC) is a rare primary malignant tumor in the skull, but mostly originates from the abnormal residual chondrocytes in the embryonic period, which grow slowly, and primarily occurs at the junction of the cartilage of the skull base. IMC is difficult to diagnose by preoperative imaging and is easily misdiagnosed. It needs to be differentiated from meningiomas, gliomas, hemangioma, fibroids, etc. Read More

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November 2021

Paleopathology of Endocranial Lesions: A Possible Case of a Middle Meningeal Artery Aneurysm in an Etruscan Child from Pontecagnano (Southern Italy).

World Neurosurg 2021 Nov 27;158:168-173. Epub 2021 Nov 27.

Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

A middle meningeal artery (MMA) aneurysm is a type of intracranial aneurysm that has been rarely documented and is not completely understood in clinical medicine and especially in pediatrics, because juvenile cases have been extremely uncommon. Vascular conditions have occasionally been diagnosed in osteoarchaeological remains, providing evidence of their occurrence in previous eras. In the present report, we have described a lesion that was highly consistent with a case of an MMA aneurysm observed in an Etruscan child, whose remains had been exhumed during archaeological excavations in the necropolis of Pontecagnano (Salerno, southern Italy). Read More

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November 2021

Squamous cell carcinoma of mandible with unusual clinical presentation: A rare case report and review of literature.

Indian J Dent Res 2021 Apr-Jun;32(2):256-260

Associate Professor, Department of Periodontology & Oral Medicine, College of Dentistry, Qassim University, Saudi Arabia.

Squamous cell carcinoma (SCC) is commonly seen malignant epithelial neoplasm of the oral cavity, which is characterized by variable clinical manifestations. It arises from dysplastic squamous epithelium. Majority of the spread of oral SCC (OSCC) to mandibular bone occurs by direct infiltration of the tumour through alveolar ridge or lingual cortical plate. Read More

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November 2021

Imaging After Sinonasal Surgery.

Neuroimaging Clin N Am 2022 Feb;32(1):55-73

Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA 22903, USA. Electronic address:

Posttreatment imaging evaluation of sinuses encompasses a wide gamut of procedures, ranging from endoscopic procedures for sinonasal inflammatory diseases to markedly radical surgeries for malignant neoplasms (with or without reconstructions), as well as providing access for surgeries involving the anterior and central skull base. Advances in both techniques and devices have expanded the use of endoscopic approaches in managing both benign and malignant lesions, in addition to being the primary surgical method for treating all medically refractive sinonasal inflammatory disorders. Familiarity with the complex anatomy in the sinonasal region and knowledge of the various procedures is indispensable in interpreting these imaging studies. Read More

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February 2022

Ectopic Primary Olfactory Neuroblastoma: Case Series and Literature Review.

World Neurosurg 2021 Nov 14. Epub 2021 Nov 14.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; Head and Neck Surgery & Forensic Dissection Research Center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Objective: Olfactory neuroblastoma (ONB) is a rare malignant tumor arising in the upper nasal cleft. Rarely, ONB may originate in ectopic sites and the impact of this on prognosis and treatment strategies continues to be debated.

Methods: A retrospective analysis was undertaken of patients with ectopic ONB treated between 2000 and 2020 in a tertiary-care referral center for skull base tumors. Read More

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November 2021