780 results match your criteria Primary Malignant Skull Tumors


Proposal for Modification of Cahan's Criteria Utilizing Molecular Genetic Analyses for Cases without Baseline Histopathology: A Unique Method Applicable to Primary Radiosurgery.

J Neurol Surg B Skull Base 2019 Feb 31;80(1):10-17. Epub 2018 May 31.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States.

 Cahan's criteria have been utilized since 1948 to establish causality between prior radiation treatment and the development of secondary malignancy. One major criterion specifies that histological and radiographic evidence collected before and after radiation treatment must confirm separate tumor types; however, pretreatment biopsy is rarely obtained prior to radiosurgery for vestibular schwannoma and many other skull base and cranial lesions. Therefore, in these cases Cahan's criteria cannot be validly applied. Read More

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http://dx.doi.org/10.1055/s-0038-1655759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365249PMC
February 2019
1 Read

Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14223

Department of Radiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.

Rationale: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base.

Patient Concerns: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. Read More

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http://dx.doi.org/10.1097/MD.0000000000014223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413PMC
January 2019
2 Reads
5.723 Impact Factor

Characteristics and management of sinonasal paragangliomas: a systematic review.

Int Forum Allergy Rhinol 2018 Dec 20. Epub 2018 Dec 20.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ.

Background: Paragangliomas of the nasal cavity and paranasal sinuses, although exceedingly rare, can exhibit frequent and aggressive recurrences. Our objective was to evaluate tumor characteristics, clinical course, management, and associated complications of sinonasal paragangliomas METHODS: A systematic review of the literature was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, searching for sinonasal paraganglioma. Studies meeting inclusion criteria were assessed for level of evidence. Read More

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http://doi.wiley.com/10.1002/alr.22261
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http://dx.doi.org/10.1002/alr.22261DOI Listing
December 2018
11 Reads
2.371 Impact Factor

Craniofacial resection of malignant tumors of the anterior skull base: a case series and a systematic review.

Acta Neurochir (Wien) 2018 Dec 7;160(12):2339-2348. Epub 2018 Nov 7.

Department of Neurosurgery, Oslo University Hospital - Rikshospitalet, PB4950 Nydalen, N-0424, Oslo, Norway.

Background: Craniofacial resection (CFR) is still considered as the gold standard for managing sinonasal malignancies of the anterior skull base (ASB), while endoscopic approaches are gaining credibility. The goal of this study was to evaluate outcomes of patients who underwent CFR at our institution and to compare our results to international literature.

Method: Retrospective analysis of all patients undergoing CFR between 1995 and 2017, and systematic literature review according to the PRISMA statement. Read More

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http://link.springer.com/10.1007/s00701-018-3716-4
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http://dx.doi.org/10.1007/s00701-018-3716-4DOI Listing
December 2018
7 Reads

Management and survival trends for adult patients with malignant gliomas in the setting of multiple primary tumors: a population based analysis.

J Neurooncol 2019 Jan 5;141(1):213-221. Epub 2018 Nov 5.

National Skull Base Center, Thousand Oaks, CA, USA.

Introduction: The impact of multiple primary tumors, in the setting of malignant glioma (MG), has not been heavily explored.

Methods: We extracted demographics and clinical data from the SEER-18 registry for adult patients with MGs. The cases were separated based on the sequence of MG diagnosis relative to the other primary tumors: Group (A) One primary only or first primary of multiple primaries and Group (B) second primary or subsequent primary tumor. Read More

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http://dx.doi.org/10.1007/s11060-018-03028-4DOI Listing
January 2019
9 Reads

IDH mutation status in a series of 88 head and neck chondrosarcomas: different profile between tumors of the Skull Base and tumors involving the facial skeleton and the Layngotracheal tract.

Hum Pathol 2018 Oct 5. Epub 2018 Oct 5.

CHRU de Tours, Service d'Anatomie et Cytologie Pathologiques, Tours, France; Université François Rabelais, Faculté de Médecine, Tours, France; Laboratoire d'étude des sarcomes osseux et remodelage des tissus calcifiés, PhyOS - INSERM UMR 1238, Faculté de Médecine de Nantes, Université de Nantes, 44034 Nantes, cedex 1, France. Electronic address:

Chondrosarcomas are rare primary malignant bone tumors that involve the head and neck region in 1% to 12% of cases. Central conventional chondrosarcoma is the most common subtype and is associated with isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene mutations in 50% to 60% of cases. We aimed to define the frequency of IDH1 and IDH2 gene mutations in a multicenter series of 88 cases of chondrosarcoma of the head and neck, including tumors involving the base of the skull (n=30), the facial skeleton (n=11), and the laryngeal and tracheal cartilages (n=47). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183037
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http://dx.doi.org/10.1016/j.humpath.2018.09.015DOI Listing
October 2018
4 Reads

Glioblastoma in the setting of prior lower grade gliomas - insights from SEER database.

Oncotarget 2018 Sep 7;9(70):33271-33277. Epub 2018 Sep 7.

National Skull Base Center, Thousand Oaks, CA, USA.

Introduction: Secondary glioblastomas (GBs) constitute a small subset of all GBs and tend to arise after a lower grade glioma. Though knowledge regarding this subset has gained traction in recent years, its definition continues to evolve, complicating its clinical management. Investigation of epidemiology and survival patterns may help provide needed insights. Read More

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http://www.oncotarget.com/fulltext/26014
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http://dx.doi.org/10.18632/oncotarget.26014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161794PMC
September 2018
14 Reads

Surgical Treatment of Sacral Chordoma: En Bloc Resection with Negative Margins is a Determinant of the Long-Term Outcome.

Surg Technol Int 2018 Nov;33:343-348

Department of Orthopedic Surgery, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Study Design: Retrospective case series.

Objective: To report the outcome of a series of patients with sacral chordoma who were surgically treated at a single center.

Summary: Chordomas are low-grade malignant tumors that arise from remnants of the notochord. Read More

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November 2018
4 Reads

Endoscopic endonasal transpterygoid transnasopharyngeal management of petroclival chondrosarcomas without medial extension.

J Neurosurg 2018 Jul 1:1-8. Epub 2018 Jul 1.

1Department of Neurosurgery, and.

Chondrosarcomas of the skull base are malignant tumors for which surgery is the primary therapeutic option. Gross-total resection has been demonstrated to improve survival in patients with these tumors. Chondrosarcomas arising from the petroclival synchondrosis harbor particularly unique anatomical considerations that have long been a barrier to achieving such a resection. Read More

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http://dx.doi.org/10.3171/2018.3.JNS172722DOI Listing
July 2018
4 Reads

[Imaging of orbital tumors in children].

Pan Afr Med J 2018 2;29:190. Epub 2018 Apr 2.

Département de Radiologie, Hôpital Mère et Enfant, Centre d'Enseignement Mohammed VI, Faculté de Médecine de Marrakech, Université Cadi Ayad, Marrakech, Maroc.

Orbital tumors in children are characterised by a wide histological diversity due to the architectural complexity of the orbit. Several classifications may be proposed according to their location, histologic type and malignant or benign character. The most common clinical manifestation is the leukocoria. Read More

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http://www.panafrican-med-journal.com/content/article/29/190
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http://dx.doi.org/10.11604/pamj.2018.29.190.14671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061813PMC
August 2018
10 Reads

Osteoradionecrosis of the Skull Base in Nasopharyngeal Carcinoma: Incidence and Risk Factors.

Int J Radiat Oncol Biol Phys 2018 Nov 28;102(3):552-555. Epub 2018 Jun 28.

Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: Nasopharyngeal carcinoma (NPC) is a type of malignancy with a high prevalence in southern China and Southeast Asia. The primary treatment modality is radiation therapy (RT). Osteoradionecrosis (ORN) of the skull base remains one of the most serious complications after RT, affecting survival time and quality of life. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.06.027DOI Listing
November 2018
7 Reads

Anterior Clinoid Metastasis Removed Extradurally: First Case Report.

J Neurol Surg Rep 2018 Apr 31;79(2):e55-e62. Epub 2018 May 31.

Semmes Murphey Neurologic & Spine Institute, Memphis, Tennessee, United States.

 We report a case of isolated metastasis on the anterior clinoid process (ACP) mimicking meningioma.  A 58-year-old male presented with headaches, right-sided visual disturbances, and blurred and double vision. The cause of double vision was partial weakness of the right III nerve, resulting from compression of the nerve by "hypertrophied" tumor-involved right anterior clinoid. Read More

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http://dx.doi.org/10.1055/s-0038-1655773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980493PMC
April 2018
24 Reads

[Application of free anterolateral thigh Kiss flap in repair of large scalp defect after malignant tumor resection].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Mar;32(3):346-349

The Second Department of Head and Neck Surgery, Department of Oncoplastic Surgery, Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha Hunan, 410013, P.R.China.

Objective: To investigate the effectiveness of free anterolateral thigh Kiss flap in repair of large scalp defect after malignant tumor resection.

Methods: Between December 2012 and December 2016,18 patients with large scalp defect after malignant tumor resection were treated. There were 16 males and 2 females with an average age of 52. Read More

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http://dx.doi.org/10.7507/1002-1892.201711046DOI Listing
March 2018
6 Reads

Primary diffuse large B-cell lymphoma in the maxilla: A case report.

Medicine (Baltimore) 2018 May;97(20):e10707

Department of Stomatology.

Rationale: Lymphomas are the second most common non-epithelial malignant tumors in the oral and maxillofacial region. Non-Hodgkin's lymphoma (NHL) develops at extranodal sites, and cases involving the maxilla account for less than 1% of all NHLs. We describe a case of diffuse large B-cell lymphoma (DLBCL) in the maxilla, and highlight the clinical signs, symptoms, differential diagnosis, and appropriate treatment of DLBCL in the oral cavity and maxillofacial region. Read More

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http://dx.doi.org/10.1097/MD.0000000000010707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976336PMC
May 2018
2 Reads

Primary Ewing Sarcoma of Frontotemporal Bone in Geriatric Patient.

World Neurosurg 2018 Jul 30;115:278-281. Epub 2018 Apr 30.

Department of Neurosurgery, T. C. Ministry of Health Okmeydani Education and Research Hospital, Istanbul, Turkey.

Background: Ewing sarcoma is a rare primary malignant bone tumor, which mainly affects children and adolescents. Calvarial bone involvement and its appearance in elderly patients are extremely rare.

Case Description: We presented a 68-year-old female patient with headache and right frontotemporal swelling. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.158DOI Listing
July 2018
16 Reads

Gait changes in patients after reconstruction of facial bones with fibula and iliac crest free vascularized flaps.

Acta Bioeng Biomech 2018 ;20(1):185-190

Department Rehabilitation, The Children's Memorial Health Institute The Children's Memorial Health Institute, Warsaw, Poland.

Purpose: Patients with malignant tumours of the oral cavity require its surgical removal and reconstruction of the bone and soft tissues. The grafts are obtained either from leg (fibula) or pelvis (iliac crest). The removal of grafts from the locomotor apparatus can impair the gait. Read More

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September 2018
5 Reads

Clinical outcome after particle therapy for meningiomas of the skull base: toxicity and local control in patients treated with active rasterscanning.

Radiat Oncol 2018 Mar 27;13(1):54. Epub 2018 Mar 27.

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. Read More

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http://dx.doi.org/10.1186/s13014-018-1002-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870393PMC
March 2018
8 Reads

Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin's lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy.

BMJ Case Rep 2018 Mar 16;2018. Epub 2018 Mar 16.

Faculty of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

A 70-year-old man presented with left loin pain without urinary symptoms. Initial investigations with CT showed enlarged para-aortic, mediastinal lymph nodes, right-side renal mass and enlarged prostate. A prostatic-specific antigen (PSA) was alarmingly high at 4750 μg/L (normal <4. Read More

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http://dx.doi.org/10.1136/bcr-2017-223637DOI Listing
March 2018
6 Reads

Parosteal osteosarcoma of mandible: A rare case report.

J Cancer Res Ther 2018 Jan-Mar;14(2):471-474

Department of Oral Medicine and Radiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

With the exception of multiple myelomas, osteosarcoma is the most frequently occurring primary malignant bone tumor with an overall incidence of 1:100,000/year. It has greatest predilection for the metaphyses, most frequently femur and tibia. However, osteosarcomas affecting the craniofacial bones are infrequent. Read More

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http://dx.doi.org/10.4103/0973-1482.176420DOI Listing
August 2018
9 Reads

Aggressive high-grade Ewing's sarcoma of maxilla: A rare case report.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S48-S53

Department of Oral and Maxillofacial Surgery ESI Hospital, Kollam, Kerala, India.

Ewing's sarcoma (ES) is an uncommon malignancy of childhood and adults that constitutes 6%-8% of all primary malignant tumors and the third-most common tumor after osteosarcoma and chondrosarcoma, frequently involves the mandible among jaw bones. This article presents a rare case of ES of maxilla in a 22-year-old male patient showing extensive lesion into skull base which was confirmed with computed tomography, dilemmatic histopathologic features in H and E which is not a frequent presentation. Histopathologic features showed monotonous round cells with hypo- and hyper-cellular areas, intralesional hemorrhage and necrosis with lesional cells positive for CD99. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_89_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824517PMC
January 2018

Recurrent epistaxis leading to diagnosis of primary sinonasal melanoma.

BMJ Case Rep 2018 Feb 16;2018. Epub 2018 Feb 16.

Internal Medicine, Saint Joseph Mercy Ann Arbor Hospital, Ypsilanti, Michigan, USA.

A 48-year-old man presented to urgent care with recurrent epistaxis over 6 months. Initially, nosebleeds were controlled with packing or cautery. Ultimately, he was referred to ear, nose and throat department and underwent nasal endoscopy which revealed polypoid tissue. Read More

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http://dx.doi.org/10.1136/bcr-2017-219832DOI Listing
February 2018
4 Reads

Skull metastasis revealing a renal tumor: A case report and review of the literature.

Int J Surg Case Rep 2018 10;43:56-60. Epub 2018 Feb 10.

El Manar-Tunis University, Faculty of medicine of Tunis, Burns and Trauma Center, Department of Neurosurgery, Ben Arous, Tunisia. Electronic address:

Background: Renal cell carcinomas represent 85% of malignant renal tumors. Typically, the tumor remains asymptomatic a long time before the appearance of urologic clinical signs. In some cases, metastasis can precede the manifestations of the primary tumor. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849813PMC
February 2018
10 Reads

Meningiomas with different histological grade in the same patient: Case report.

Medicine (Baltimore) 2017 Dec;96(50):e9086

Department of Neurosurgery, The Third Hospital of MianYang, Sichuan, China.

Rationale: Meningiomas are mostly regarded as benign tumors histologically,accounting for 13% to 26% of all primary intracranial tumors.It is testified that multiple meningiomas occur in <10% of cases.A case of concurrent grades I and II in the same patient in our hospital was described. Read More

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http://dx.doi.org/10.1097/MD.0000000000009086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815716PMC
December 2017
3 Reads

Transdural Propagation of Glioblastoma Through Foramen Rotundum.

World Neurosurg 2018 Mar 23;111:240-242. Epub 2017 Dec 23.

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background: Glioblastoma, also known as glioblastoma multiforme, is the most common primary malignant cerebral tumor in adults. Although glioblastoma multiforme is one of the most aggressive tumors in the brain, propagation through the dura mater is rare.

Case Description: A 59-year-old man presented with progressive headache and aphasia. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.12.097DOI Listing
March 2018
21 Reads

A rare case of angiosarcoma with skull masses and erythropenia and thrombocytopenia: A case report and review of literature.

Medicine (Baltimore) 2017 Dec;96(49):e8787

aDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, HangzhoubDepartment of Neurosurgery, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, YiwucDepartment of Pathology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, China.

Rationale: Primary splenic angiosarcoma (PSA) is a rare, fatal neoplasm originating from sinusoidal vascular endothelial cells, and usually metastasizes and almost always has a poor prognosis. Surgical excision is the main treatment of this highly malignant disease.

Patient Concerns: We reported a special case of a 68-year-old female who had a 6-month history of scalp masses. Read More

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http://dx.doi.org/10.1097/MD.0000000000008787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728852PMC
December 2017
8 Reads

Prosthetic rehabilitation involving the use of implants following a fibula free flap reconstruction in the treatment of Osteosarcoma of the maxilla: a case report.

Clin Ter 2017 Nov-Dec;168(6):e392-e396

M.D., D.D.S., Università degli studi di Roma La Sapienza.

Introduction: Osteosarcoma is an aggressive primary bone tumor composed of connective tissue cells directly producing osteoid and bone. Prosthetic rehabilitations in post-oncological patients after bone reconstruction are not substantially different than those of patients affected by severe atrophy of upper or lower jaw after bone reconstruction. The treatment for patients with a malignant neoplasia of the oral cavity requires multidisciplinary approach by a team of different specialists that follow the patient through the phases of diagnosis, therapy and oral rehabilitation. Read More

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http://dx.doi.org/10.7417/T.2017.2040DOI Listing
April 2018
7 Reads

Squamous cell carcinoma arising from a keratocystic odontogenic tumor: a case report.

J Med Case Rep 2017 Dec 1;11(1):335. Epub 2017 Dec 1.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.

Background: The term "primary intraosseous squamous cell carcinoma" was introduced in 2005 by the World Health Organization with three subcategories. Squamous cell carcinoma arising from the lining of an odontogenic cyst is one important rare subcategory of such lesions with an incidence of 0.01 to 0. Read More

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http://dx.doi.org/10.1186/s13256-017-1486-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710129PMC
December 2017
4 Reads

A new therapeutic proposal for inoperable osteosarcoma: Photodynamic therapy.

Photodiagnosis Photodyn Ther 2018 Mar 22;21:79-85. Epub 2017 Nov 22.

Laboratory of Multidisciplinary Research, Postgraduate Program in Health Sciences, São Francisco University, Bragança Paulista, SP, Brazil. Electronic address:

Background: Osteosarcoma, a malignant tumor characterized by bone or osteoid formation, is the second most common primary bone neoplasm. Clinical symptoms include local and surrounding pain, unrelieved by rest or anesthesia. Osteosarcoma has a poor chemotherapeutic response with prognosis dependent on complete tumor excision. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2017.11.009DOI Listing
March 2018
9 Reads

Giant Osteosarcoma of the Mandible.

J Coll Physicians Surg Pak 2017 Sep;27(9):S117-S119

Department of Oral Medicine and Radiology, Government Dental College, Jaipur, India.

Osteosarcoma is a rare primary malignant bone tumor with considerable variations not only in clinical and histologic appearance, but also in the course and prognosis of the disease. It mainly occurs in the metaphyseal region of long bones. Jaw osteosarcomas are relatively rare as compared to those occurring in long bones and share similar histopathologic features, but biologically behave in a different manner. Read More

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http://dx.doi.org/280DOI Listing
September 2017
1 Read
0.318 Impact Factor

Detection of Non-FDG-Avid Residual Sinonasal Malignant Melanoma in the Skull Base With 11C-Choline PET and Contrast-Enhanced MRI.

Clin Nucl Med 2017 Nov;42(11):885-886

From the *Department of Nuclear Medicine, and †Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Primary sinonasal melanoma is a rare disease. We present a case of melanoma in sinuses without abnormal F-FDG activity anywhere in the scanned portion of the body. In further assessment, C-choline PET/CT revealed high activity in the paranasal sinuses, skull base, and adjacent brain, in agreement with the high signal on contrast-enhanced T1-weighted MRI scan, which suggested the residual tumor. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001836DOI Listing
November 2017
18 Reads
3.931 Impact Factor

Understanding the potentiality of accelerator based-boron neutron capture therapy for osteosarcoma: dosimetry assessment based on the reported clinical experience.

Radiat Oncol 2017 Aug 15;12(1):130. Epub 2017 Aug 15.

National Atomic Energy Commission (CNEA), Av. General Paz, 1499, Buenos Aires, Argentina.

Background: Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adjuvant and neo-adjuvant chemotherapy that markedly increased the success rate in the treatment, aggressive surgery is still needed and a considerable percentage of patients do not survive due to recurrences or early metastases. Boron Neutron Capture Therapy (BNCT), an experimental radiotherapy, was investigated as a treatment that could allow a less aggressive surgery by killing infiltrated tumour cells in the surrounding healthy tissues. Read More

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http://dx.doi.org/10.1186/s13014-017-0860-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557419PMC
August 2017
18 Reads

Pediatric head and neck bone sarcomas: An analysis of 204 cases.

Int J Pediatr Otorhinolaryngol 2017 Sep 15;100:71-76. Epub 2017 Jun 15.

Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

Objectives: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull.

Methods: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. Read More

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http://dx.doi.org/10.1016/j.ijporl.2017.06.003DOI Listing
September 2017
6 Reads

Primary intracranial dural-based Ewing sarcoma/peripheral primitive neuroectodermal tumor mimicking a meningioma: A rare tumor with review of literature.

Asian J Neurosurg 2017 Jul-Sep;12(3):351-357

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is a malignant small, round cell tumor arising from bone and soft tissue in children and young adults. It can occur at osseous and extraosseous sites. Its usual locations are diaphysis of long bones followed by pelvis, ribs, vertebrae, and rarely skull. Read More

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http://dx.doi.org/10.4103/1793-5482.185060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532914PMC
August 2017
16 Reads

Esthetically Favorable Surgical Alternative for the Removal of Sinonasal Malignant Tumors-The Modified Facial Degloving Technique.

J Oral Maxillofac Surg 2017 Oct 29;75(10):2272.e1-2272.e10. Epub 2017 Jun 29.

Professor and Head of Department, Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Szeged, Hungary.

Purpose: The widely used external approach (Weber-Fergusson incision) for the removal of maxillary ethmoid tumors leaves stigmatizing scars and deformities on the patient's face. As an alternative technique, the scarless facial degloving approach was first described in the 1970s; since then, several modifications have been developed.

Patients And Methods: The authors have been using a modified facial degloving technique for 7 years to remove maxillary ethmoid tumors. Read More

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http://dx.doi.org/10.1016/j.joms.2017.06.036DOI Listing
October 2017
25 Reads

Primary pituitary neuroendocrine tumor: Case report and literature review.

Surg Neurol Int 2017 5;8:101. Epub 2017 Jun 5.

Neurosurgery-Neurotraumatology Unit of University Hospital of Parma, Parma and Department of Neurosurgery, Reggio Emilia, Italy.

Background: Neuroendocrine tumors (NET) originate from the diffuse neuroendocrine system. These can arise in almost every organ of the body, although they are most commonly found in the gastrointestinal tract and respiratory system. The skull base and sellar region are extremely rare sites for neuroendocrine carcinoma. Read More

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http://dx.doi.org/10.4103/sni.sni_450_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473081PMC
June 2017
4 Reads

Soft Tissue Enhancement and Implant Placement Following Partial Mandibulectomy Due to Squamous Cell Carcinoma.

J Oral Implantol 2017 Aug 19;43(4):291-296. Epub 2017 Jun 19.

6   University of Bologna, Italy.

Many dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Problems arise from the lack of adequate bone quality and quantity. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-17-00013DOI Listing
August 2017
24 Reads

Geographic region: Does it matter in cutaneous melanoma of the head and neck?

Laryngoscope 2017 12 5;127(12):2763-2769. Epub 2017 Jun 5.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.

Objectives/hypothesis: The head and neck are two of the most common locations for cutaneous melanoma. We present the first population-based analysis of geographic differences in anatomic subsite, clinicopathologic and demographical traits, histopathologic subtype, treatment modality, and disease-specific survival (DSS) of cutaneous head and neck melanoma (CHNM).

Study Design: Retrospective database analysis. Read More

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http://dx.doi.org/10.1002/lary.26663DOI Listing
December 2017
11 Reads

Neural Tumors of the Orbit -- What Is New?

Asia Pac J Ophthalmol (Phila) 2017 May-Jun;6(3):273-282

Florida Lions Ocular Pathology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Primary neural tumors of the orbit account for approximately 10% of all orbital tumors. Different tumor entities include meningiomas, optic nerve gliomas, neurofibromas, schwannomas, malignant peripheral nerve sheath tumors, and granular cell tumors. This review summarizes current concepts regarding epidemiology, clinical presentation, diagnosis, pathology, immunohistochemistry, prognosis, and treatment for neural tumors of the orbit based on the available literature. Read More

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http://dx.doi.org/10.22608/APO.2017157DOI Listing
September 2017
12 Reads

Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female - a case report and literature review.

Ital J Pediatr 2017 Mar 29;43(1):32. Epub 2017 Mar 29.

Department of Oncology, Yerevan State Medical University, Yerevan, Armenia.

Background: Giant cell tumor of bone (GCT) is a rare primary bone tumor, which can metastasize and undergo malignant transformation. The standard treatment of GCT is surgery. In patients with unresectable or metastatic disease, additional therapeutic options are available. Read More

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http://dx.doi.org/10.1186/s13052-017-0353-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372271PMC
March 2017
5 Reads

Giant melanotic neuroectodermal tumor of infancy (melanotic progonoma) of the head and neck: report of a malignant case.

J Neurosurg Pediatr 2017 May 24;19(5):538-545. Epub 2017 Feb 24.

Departments of 1 Paediatric Neurosurgery.

Melanotic neuroectodermal tumor of infancy is a rare congenital pigmented neoplasm of neural crest origin, locally aggressive, growing rapidly and developing during the 1st year of life. It most commonly arises from the maxilla, cranial vault, and mandible. Occasionally, it exhibits malignant behavior with local lymph nodes involvement. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/19/5/ar
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http://dx.doi.org/10.3171/2016.11.PEDS16509DOI Listing
May 2017
24 Reads

Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging.

Neuroradiology 2017 Apr 13;59(4):327-342. Epub 2017 Mar 13.

Division of Radiology, Department of Imaging and Medical Informatics, Geneva University Hospital, University of Geneva, Rue Gabrielle Perret Gentil 4, 1211, Geneva, Switzerland.

Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin. Read More

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http://dx.doi.org/10.1007/s00234-017-1798-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394153PMC
April 2017
13 Reads

Ewing's sarcoma of the cranial vault: a case report.

Acta Clin Belg 2017 Dec 13;72(6):443-446. Epub 2017 Mar 13.

a Department of Oncology and Radiotherapy , Habib Bourguiba University Hospital , Sfax , Tunisia.

Ewing's sarcoma is a malignant tumor that mainly affects young patients. It represents 10% of primary malignant tumors of the bone and 3% of malignant tumors of the child. Cranial localization is extremely rare representing less than 1% of all the localizations. Read More

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http://dx.doi.org/10.1080/17843286.2017.1300989DOI Listing
December 2017
3 Reads

CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare?

Biomed Res Int 2017 24;2017:1456473. Epub 2017 Jan 24.

Clinic of Oncological Surgery of Children and Adolescents, Institute of Mother and Child, Warsaw, Poland.

. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. . Read More

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http://dx.doi.org/10.1155/2017/1456473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294350PMC
March 2017
21 Reads

Multicenter experiences in temporal bone cancer surgery based on 89 cases.

PLoS One 2017 22;12(2):e0169399. Epub 2017 Feb 22.

ENT Department, Medical University, Poznań, Poland.

Objective: To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers.

Study Design: Retrospective case review.

Setting: Four tertiary referral centers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321293PMC
August 2017
8 Reads

Primary Ameloblastoma of the Temporal Bone.

J Oral Maxillofac Surg 2017 Jun 24;75(6):1300.e1-1300.e4. Epub 2017 Jan 24.

Professor and Head, Department of Otology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Ameloblastoma is a locally aggressive tumor derived from odontogenic epithelium. Although benign, its clinical behavior can often exhibit malignant characteristics. It is marked by slow and persistent growth with infiltration of adjacent tissues. Read More

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http://dx.doi.org/10.1016/j.joms.2017.01.014DOI Listing
June 2017
3 Reads

Extracranial Meningioma Presenting as an Eyebrow Mass.

J Craniofac Surg 2017 Jun;28(4):e305-e307

Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea.

Meningiomas originate in the central nervous system and are the most common intracranial benign tumor. However, although rarely, they can develop extracranially. Primary extracranial meningiomas are frequently misdiagnosed, resulting in inappropriate clinical management. Read More

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http://dx.doi.org/10.1097/SCS.0000000000003555DOI Listing
June 2017
9 Reads

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.

Ann Oncol 2017 Jun;28(6):1230-1242

Chordoma Foundation, Durham, USA.

Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. Read More

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http://dx.doi.org/10.1093/annonc/mdx054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452071PMC
June 2017
8 Reads

The PI3K inhibitor GDC-0941 enhances radiosensitization and reduces chemoresistance to temozolomide in GBM cell lines.

Neuroscience 2017 03 29;346:298-308. Epub 2017 Jan 29.

Department of Skull Base Surgery Center, Otorhinolaryngology Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing 100053, China. Electronic address:

Glioblastoma multiforme (GBM) is among the most lethal of all human tumors. It is the most frequently occurring malignant primary brain tumor in adults. The current standard of care (SOC) for GBM is initial surgical resection followed by treatment with a combination of temozolomide (TMZ) and ionizing radiation (IR). Read More

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http://dx.doi.org/10.1016/j.neuroscience.2017.01.032DOI Listing
March 2017
10 Reads

Isolated sphenoid sinus opacification: A systematic review.

Am J Otolaryngol 2017 Mar - Apr;38(2):237-243. Epub 2017 Jan 19.

Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Australia; Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.

Objective: Unilateral sphenoid sinus opacification (SSO) on imaging is a common incidental radiologic finding. Inflammatory sinus disease is rarely isolated to one sinus cavity therefore SSO raises the potential for neoplastic etiology. The clinical significance of SSO was evaluated and compared to maxillary sinus opacification (MSO). Read More

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http://dx.doi.org/10.1016/j.amjoto.2017.01.014DOI Listing
December 2017
23 Reads

Unusual skull tumors with psammomatoid bodies: a diagnostic challenge.

Clin Neuropathol 2017 May/Jun;36 (2017)(3):114-120

Aim: We describe a series of three diagnostically challenging, histologically similar fibro-osseous skull masses.

Methods: The cases were identified in our archives among 50,000 neuropathology specimens. A comprehensive review of the histological, immunohistochemical, ultrastructural, and imaging features as well as the clinical outcome was performed. Read More

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http://dx.doi.org/10.5414/NP300997DOI Listing
January 2018
19 Reads