760 results match your criteria Primary Lung Tuberculosis Imaging


Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II).

Trials 2020 Jun 12;21(1):520. Epub 2020 Jun 12.

Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, 430064, Hubei, China.

Objectives: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.

Trial Design: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.

Participants: Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290137PMC
June 2020
2.117 Impact Factor

Orofacial tuberculosis: A diagnostic challenge.

IDCases 2020 15;21:e00825. Epub 2020 May 15.

Oral and Maxillofacial Surgery Board Resident, Department of Oral and Maxillofacial Surgery, Medical City Complex, Bab Al Muadham, 10047, Baghdad, Iraq.

Tuberculosis is typically a pulmonary chronic infectious disease with a high prevalence in developing countries which carries a substantial rate of mortality. Extrapulmonary disease may occur, mainly second to the endogenous spread of the pathogen from the primary site. Oral or mandibular involvement represents a minority among the reported cases. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242870PMC

The correlation between CT features and insulin resistance levels in patients with T2DM complicated with primary pulmonary tuberculosis.

J Cell Physiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Medical Imaging, The Fourth People's Hospital of Huai'an, Huai'an, Jiangsu, China.

The aim is to investigate the correlation between computed tomography (CT) features and insulin resistance levels in patients with type 2 diabetes mellitus (T2DM) complicated with primary pulmonary tuberculosis (PTB). Nearly, 268 untreated PTB patients complicated with T2DM were divided into two groups according to the optimal cutoff value of HOMA-IR score for the Chinese population: HOMA-IR ≤ 2.69 (Group I: 74 patients), >2. Read More

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http://dx.doi.org/10.1002/jcp.29741DOI Listing

The history of respiratory disease management.

Authors:
Duncan Geddes

Medicine (Abingdon) 2020 Apr 4;48(4):239-243. Epub 2020 Mar 4.

is an Honorary Consultant at the Royal Brompton Hospital, London and Professor of Respiratory Medicine at Imperial College London, UK. His main clinical and research interests are cystic fibrosis, lung cancer and emphysema. He was President of the British Thoracic Society and Chairman of Asthma UK. Competing interests: none declared.

Over the past 200 years lung diseases have shifted from infections - tuberculosis, pneumonia - to diseases of dirty air - chronic obstructive pulmonary disease, asthma and lung cancer. New diseases have emerged from industrial pollution and HIV infection, while better imaging has revealed others previously unrecognized. Scientific advances in microbiology, imaging and clinical measurement have improved diagnosis and allowed better targeted treatment. Read More

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http://dx.doi.org/10.1016/j.mpmed.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102619PMC

In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment?

Nanomaterials (Basel) 2020 Mar 21;10(3). Epub 2020 Mar 21.

Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.

The active targeting to alveolar macrophages (AM) is an attractive strategy to improve the therapeutic efficacy of 'old' drugs currently used in clinical practice for the treatment of pulmonary tuberculosis. Previous studies highlighted the ability of respirable solid lipid nanoparticle assemblies (SLNas), loaded with rifampicin (RIF) and functionalized with a novel synthesized mannose-based surfactant (MS), both alone and in a blend with sodium taurocholate, to efficiently target the AM via mannose receptor-mediated mechanism. Here, we present the in vivo biodistribution of these mannosylated SLNas, in comparison with the behavior of both non-functionalized SLNas and bare RIF. Read More

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http://dx.doi.org/10.3390/nano10030568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153707PMC

Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis.

Case Rep Oncol 2020 Jan-Apr;13(1):139-144. Epub 2020 Feb 13.

Department of Medical Oncology-Hematology, Hamad Medical Corporation Qatar, Doha, Qatar.

Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of the thyroid, kidney, and trophoblasts as well as sarcomas. Here we present the case of a 35-year-old Indian male who presented with a 2-month history of dry cough and shortness of breath. Read More

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http://dx.doi.org/10.1159/000505685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098354PMC
February 2020

Towards more accurate F-fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging in active and latent tuberculosis.

Int J Infect Dis 2020 Mar 27;92S:S85-S90. Epub 2020 Feb 27.

Institute of Nuclear Medicine, UCLH NHS Foundation Trust, 235 Euston Road, London NW1 2BU, United Kingdom. Electronic address:

Tuberculosis (TB) is one of the leading causes of death worldwide. Although the disease is curable and preventable, it is underdiagnosed in many parts of the world. Positron emission tomography (PET) imaging using F-FDG in TB can localise disease sites and the extent of disease. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.02.017DOI Listing

Differentiation of Intraspinal Tuberculosis and Metastatic Cancer Using Magnetic Resonance Imaging.

Infect Drug Resist 2020 4;13:341-349. Epub 2020 Feb 4.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People's Republic of China.

Purpose: This study aimed to explore the differences in the magnetic resonance imaging (MRI) findings between intraspinal tuberculosis and metastatic cancer, which may aid in making the correct diagnosis.

Patients And Methods: The clinical features and MRI findings of 15 patients with intraspinal tuberculosis and 11 patients with intraspinal metastatic cancers were retrospectively analyzed.

Results: The mean ages of the patients with intraspinal tuberculosis and metastatic cancer were 26. Read More

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http://dx.doi.org/10.2147/IDR.S224238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007797PMC
February 2020

Ultrasound as the first imaging method in severe lung disease. Considerations about a case of pulmonary tuberculosis and review of the literature.

Med Ultrason 2020 03;22(1):102-104

Department of Anatomy, UMF "Iuliu Hatieganu" Cluj-Napoca.

Abdominal ultrasound (US) performed as a "primary imaging procedure" is an important diagnostic tool in gastroenterol-ogy. Expanding the routine investigation to the lower thoracic region might sometimes accelerate the diagnosis in inconclusive manifestations such as pulmonary pathology.US is a valuable tool in evaluating patients with breathing difficulties, chest pain, hypoxia, or chest trauma. Read More

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http://dx.doi.org/10.11152/mu-1890DOI Listing

Primary Pulmonary MALT Lymphoma: A Case Report and Literature Review.

Biomed Hub 2019 Sep-Dec;4(3):1-5. Epub 2019 Sep 24.

Pneumology Department, Hospital Garcia de Orta, Almada, Portugal.

Background: Primary pulmonary MALT (mucosa-associated lymphoid tissue) lymphoma is a rare entity that imposes a rigorous and demanding diagnostic work-up.

Case Report: We present the case of a 74-year-old female non-smoker with a previous healed pulmonary tuberculosis and a history of arterial hypertension and fibromyalgia. She was referred to the pulmonology clinic to investigate a right inferior lobe (RIL) rounded pulmonary opacity (4 × 3. Read More

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http://dx.doi.org/10.1159/000502488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985883PMC
September 2019

Detection of secondary causes of spontaneous pneumothorax: Comparison between computed tomography and chest X-ray.

Diagn Interv Imaging 2020 Apr 18;101(4):217-224. Epub 2019 Dec 18.

Department of Respiratory Medicine, AP-HP, hôpital Tenon, 75020 Paris, France; Thoracic Surgery Department, AP-HP, hôpital Tenon, 75020 Paris, France; Thoracic Oncology Department, Paris-Diderot University, AP-HP, hôpital Bichat, 75018 Paris, France. Electronic address:

Purpose: The aim of this study was to compare the effectiveness of chest X-ray to that of thoracic computed tomography (CT) for the detection of the causes of secondary spontaneous pneumothorax (SP).

Methods: A prospective cohort of patients with SP was studied. All chest X-ray and CT examinations of the patients were reviewed retrospectively by an expert radiologist blinded to clinical data. Read More

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http://dx.doi.org/10.1016/j.diii.2019.11.002DOI Listing

Pediatric Mandible Reconstruction for Osteomyelitis During Largest Reported Mycobacterium Abscessus Outbreak.

J Craniofac Surg 2020 Jan/Feb;31(1):274-277

Department of Plastic Surgery, University of California Irvine.

In 2016, water lines at a children's dental clinic in Orange County, California were contaminated with Mycobacterium abscessus (MA), a non-tuberculosis rapidly-growing mycobacterium, leading to the largest MA outbreak ever reported. Mandatory reporting and active case finding directed by the Public Health Department was conducted in collaboration with community Pediatric Infectious Disease physicians for patients who underwent dental pulpotomies at the contaminated Dental Clinic from January 1 to September 6, 2016. Seventy-one cases (22 confirmed and 49 probable) were identified. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006070DOI Listing

Isolated hepatic tuberculosis presenting as hydatid cyst.

Clin J Gastroenterol 2020 Jun 22;13(3):408-412. Epub 2019 Nov 22.

Department of Gastrointestinal Surgery, Sahloul Hospital, University of Sousse, Sousse, Tunisia.

Primary hepatic tuberculosis is a rare manifestation of extra-pulmonary tuberculosis even in highly endemic countries. The incidence of hepatic tuberculosis has increased in the recent years due to high prevalence of HIV/AIDS. Radiological imaging is an important tool for making the diagnosis, but often the imaging findings are non-specific and may mimic other benign or malignant hepatic diseases. Read More

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http://dx.doi.org/10.1007/s12328-019-01071-wDOI Listing

Comparative evaluation of Xpert MTB/RIF and the new Xpert MTB/RIF ultra with respiratory and extra-pulmonary specimens for tuberculosis case detection in a low incidence setting.

J Clin Tuberc Other Mycobact Dis 2019 May 12;15:100094. Epub 2019 Mar 12.

Regional Reference Mycobacteriology Laboratory, Clinical Pathology Laboratory, United Hospitals, Ancona, Italy.

Background: The Xpert MTB/RIF assay (Xpert) is an automated molecular test for the detection of tuberculosis and rifampin resistance (RIF-R), but it lacks sensitivity in smear-negative samples and some limitations in determination of RIF-R have also been reported. The new Xpert MTB/RIF Ultra (Ultra) was developed to overcome these limitations. We aimed to compare Ultra and Xpert diagnostic accuracy setting culture and drug susceptibility testing as reference standards. Read More

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http://dx.doi.org/10.1016/j.jctube.2019.100094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830143PMC

Extrapulmonary Tuberculosis: Pathophysiology and Imaging Findings.

Radiographics 2019 Nov-Dec;39(7):2023-2037

From the Department of Radiology, Fundación Valle del Lili-Universidad Icesi, Carrera 98 #18-49, Cali, Colombia.

Extrapulmonary tuberculosis (TB) represents approximately 15% of all TB infections. It is difficult to diagnose on the basis of imaging characteristics and clinical symptoms, and biopsy is required in many cases. Radiologists must be aware of the imaging findings of extrapulmonary TB to identify the condition in high-risk patients, even in the absence of active pulmonary infection. Read More

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http://dx.doi.org/10.1148/rg.2019190109DOI Listing
November 2019

Viable Mycobacterium tuberculosis in sputum after pulmonary tuberculosis cure.

BMC Infect Dis 2019 Oct 30;19(1):923. Epub 2019 Oct 30.

Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, P.O. Box 7804, N-5020, Bergen, Norway.

Background: Pulmonary tuberculosis (TB) with detectable Mycobacterium tuberculosis in the sputum is a major source of transmission. In resource limited TB endemic settings, cure is declared through sputum smear examination for acid fast bacilli without performing culture. This may lead to erroneous treatment outcomes as viable bacteria may be missed due to the low sensitivity of direct smear method. Read More

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http://dx.doi.org/10.1186/s12879-019-4561-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822412PMC
October 2019

Adenocarcinoma of the Lung Presenting with Intrapulmonary Miliary Metastasis.

Cureus 2019 Aug 19;11(8):e5430. Epub 2019 Aug 19.

Internal Medicine, Sindh Medical College, Karachi, PAK.

Miliary mottling on imaging is usually infectious in etiology and is less commonly seen with metastatic cancers. The cancers that are reported to cause miliary metastases include secondaries from cancers of the thyroid, kidney, trophoblasts, etc. Here, we report a case of a 63-year-old female who presented with prolonged cough and shortness of breath and whose imaging showed diffuse bilateral miliary nodules. Read More

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http://dx.doi.org/10.7759/cureus.5430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797010PMC
August 2019
1 Read

[Expression discordances and clinical values of ER, PR, HER-2 and Ki-67 in primary and metastatic breast cancer].

Zhonghua Zhong Liu Za Zhi 2019 Sep;41(9):681-685

Department of Medical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210009, China.

To investigate the expression discordances of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor2 (HER-2) and Ki-67 in primary and metastatic breast cancer specimens and explore the clinical significances. Biopsies of metastatic lesions were performed in 203 patients with breast cancer recurrence and metastasis indicated by physical examination and/or imaging examination. We confirmed pathological properties and assessed the expressions of ER, PR, HER-2 and Ki-67 in primary and metastatic lesions, their relationships with prognosis were also analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.09.007DOI Listing
September 2019
1 Read

Of Cestodes and Men: Surgical Treatment of a Spinal Hydatid Cyst.

J Neurol Surg A Cent Eur Neurosurg 2020 Jan 4;81(1):86-90. Epub 2019 Sep 4.

Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Göttingen, Göttingen, Germany.

Background:  The cestode causes hydatid disease. In addition to manifestations in the liver and lung, it can lead to cystic lesions in the spine.

Case Description:  We report a 42-year-old male patient with primary hydatid disease in the eighth thoracic vertebra. Read More

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http://dx.doi.org/10.1055/s-0039-1693707DOI Listing
January 2020
8 Reads

Computed tomography-based predictive nomogram for differentiating primary progressive pulmonary tuberculosis from community-acquired pneumonia in children.

BMC Med Imaging 2019 08 8;19(1):63. Epub 2019 Aug 8.

Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Beijing, 100045, China.

Background: To investigate the value of predictive nomogram in optimizing computed tomography (CT)-based differential diagnosis of primary progressive pulmonary tuberculosis (TB) from community-acquired pneumonia (CAP) in children.

Methods: This retrospective study included 53 patients with clinically confirmed pulmonary TB and 62 patients with CAP. Patients were grouped at random according to a 3:1 ratio (primary cohort n = 86, validation cohort n = 29). Read More

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http://dx.doi.org/10.1186/s12880-019-0355-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688341PMC
August 2019
1 Read

Heterogeneity of latent tuberculosis infection in a patient with lung cancer.

J Infect Public Health 2020 Jan 2;13(1):151-153. Epub 2019 Aug 2.

Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, 1-5-8 Hatanodai Shinagawa-ku, Tokyo 142-8666, Japan.

Latent tuberculosis infection may become a source of tuberculosis dissemination, even in a subclinical case, which have no abnormalities in the pulmonary parenchyma based on imaging studies. In this case, we presented tiny granulomas beside squamous cell carcinoma in a woman positive for interferon-γ release assay (IGRA). She had no symptoms or abnormalities in the parenchyma, except for the primary lesion. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.07.009DOI Listing
January 2020
1 Read

Truncating mutations in exons 20 and 21 of can cause primary ciliary dyskinesia without associated syndromic symptoms.

J Med Genet 2019 11 31;56(11):769-777. Epub 2019 Jul 31.

Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.

Background: Primary ciliary dyskinesia (PCD) is a motile ciliopathy, whose symptoms include airway infections, male infertility and . Apart from the typical forms of PCD, rare syndromic PCD forms exist. Mutations of the X-linked gene cause several syndromic ciliopathies, including oral-facial-digital syndrome type 1, Joubert syndrome type 10 (JBTS10), and Simpson-Golabi-Behmel syndrome type 2, the latter causing the X-linked syndromic form of PCD. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105918DOI Listing
November 2019
6 Reads

Orbital tuberculosis with involvement of the eyelid: An unusual presentation.

Natl Med J India 2018 Sep-Oct;31(5):279-280

Department of Respiratory Medicine, King George Medical University, Chowk, Lucknow 226003, Uttar Pradesh, India.

Although cases of ocular tuberculosis (TB) are increasing, involvement of the eyelid and orbit are unusual. These cases occur secondary to the presence of TB elsewhere in the body, usually pulmonary TB. The primary infection of orbit or eyelid is a rare occurrence. Read More

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http://dx.doi.org/10.4103/0970-258X.261198DOI Listing
October 2019
2 Reads

High rate of transmission in a pulmonary tuberculosis outbreak in a primary school, north-eastern Italy, 2019.

Euro Surveill 2019 Jun;24(24)

Department of Infectious Diseases, National Health Institute (Istituto Superiore di Sanità), Rome, Italy.

Italy is a low-incidence country for tuberculosis (TB). We describe a TB outbreak in a primary school in north-eastern Italy, involving 10 cases of active pulmonary disease and 42 cases of latent infection. The index case was detected in March 2019, while the primary case, an Italian-born schoolteacher, was likely infectious since January 2018. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.24.1900332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582512PMC
June 2019
2 Reads

Primary hepatic tuberculosis masquerading as intrahepatic cholangiocarcinoma.

Indian J Tuberc 2019 Apr 8;66(2):310-313. Epub 2018 Jan 8.

Associate Professor in Dept of Pulmonary Medicine, Goa Medical College, 2/f5 Kamat Complex, Tonca, Caranzalem, Goa 403002, India.

Abdominal tuberculosis is a common clinical entity in Indian subcontinent; however, hepatic tuberculosis in the absence of miliary abdominal tuberculosis is restricted to the case reports and small case series in English literature. It mimics common liver diseases like liver abscess and tumours. We report a case of 38 years old male presenting with abdominal pain, loss of appetite and weight initially misdiagnosed as intrahepatic cholangiocarcinoma on magnetic resonance imaging and FNAC of the lesion but later diagnosed as a case of hepatic tuberculosis on post operative histopathology specimen. Read More

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http://dx.doi.org/10.1016/j.ijtb.2017.12.017DOI Listing
April 2019
11 Reads

A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer.

Acta Med Port 2019 Apr 30;32(4):316-320. Epub 2019 Apr 30.

Pulmonary Diagnosis Center Dr. Ribeiro Sanches. Lisboa. Portugal.

Granulomatous pneumonitis is a rare complication of bacillus Calmette-Guerin immunotherapy following intravesical administration of bacillus Calmette-Guerin. The authors present an unusual case of a 67-year-old man who developed mild and non-specific symptoms, following intravesical bacillus Calmette-Guerin instillations. Examinations revealed features of miliary tuberculosis and granuloma suggestive of mycobacterial infection. Read More

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http://dx.doi.org/10.20344/amp.10250DOI Listing
April 2019
26 Reads

CT imaging features of thin-walled cavitary squamous cell lung cancer.

Adv Respir Med 2019 ;87(2):114-117

Department of Radiology, National Tuberculosis and Lung Diseases Research Institute, płocka 26, 01-138 warsaw, Poland.

Primary lung cancer manifesting as a thin-walled solitary cavity, occurs relatively infrequently. The most common histologic type presenting such a pattern is squamous cell cancer, followed by adenocarcinoma, and finally - large cell cancer. Cavitation is typically not seen in small cell lung cancer. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
Publisher Site
http://dx.doi.org/10.5603/ARM.2019.0018DOI Listing
December 2019
19 Reads

Endovascular treatment of a ruptured thoracic aortic pseudoaneurysm secondary to Pott disease during a spine surgery: A case report and a literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15306

Department of Orthopedic Surgery.

Rationale: The coexistence of a tuberculous aortic pseudoaneurysm and Pott disease in patients with a history of tuberculosis (TB) is relatively rare, and the treatment strategies remain still controversial.

Patient Concerns: A 57-year-old female patient with a history of primary pulmonary TB presented with symptoms of breathlessness, chest pain, weight loss, and fever. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a thoracic aortic pseudoaneurysm secondary to Pott disease at T11/12 level. Read More

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http://dx.doi.org/10.1097/MD.0000000000015306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494369PMC
April 2019
5 Reads

Sensitivity and specificity of routine diagnostic work-up for tuberculosis in lung clinics in Yogyakarta, Indonesia: a cohort study.

BMC Public Health 2019 Apr 2;19(1):363. Epub 2019 Apr 2.

University of Groningen, University Medical Center Groningen, Department of Internal Medicine/ Infectious Diseases, Groningen, The Netherlands.

Background: Establishing a correct diagnosis is challenging. We aimed to investigate the sensitivity and specificity of routine tuberculosis (TB) diagnostic work-up in lung clinics in Indonesia, a country with the third highest TB burden and the second highest gap between notifications of TB cases and the best estimate of incident cases in the world.

Methods: In the lung clinics of the Province of Yogyakarta, Indonesia, we recruited all consecutive patients with symptoms suggesting TB, aged ≥18 years. Read More

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http://dx.doi.org/10.1186/s12889-019-6658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444523PMC
April 2019
2 Reads

Thoracic Radiography Characteristics of Drug Sensitive Tuberculosis and Multi Drug Resistant Tuberculosis: A Study of Indonesian National Tuberculosis Prevalence Survey.

Acta Medica (Hradec Kralove) 2019 ;62(1):24-29

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia.

Background: Tuberculosis (TB) remains a burden globally, including Indonesia. The primary objective of this study is to reveal the chest radiography characteristic of drug-sensitive TB (DS-TB) and multi-drug resistant TB (MDR-TB) in the Indonesian national tuberculosis prevalence survey 2013-2014. The secondary objective is to explore the correlation and incidence rate of chest radiography lesion of DS-TB and MDR-TB cases. Read More

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http://dx.doi.org/10.14712/18059694.2019.42DOI Listing
August 2019
9 Reads

Tuberculous pericarditis mimicking multiple tumors in pericardial effusion.

J Int Med Res 2019 May 21;47(5):2262-2268. Epub 2019 Mar 21.

4 Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Tuberculosis is still the leading cause of pericardial disease in developing nations. A definite diagnosis of tuberculosis is usually relatively difficult, especially when its manifestations are not typical. We report a 19-year-old man who presented with chest obstruction, shortness of breath, edema of the lower extremities, and mild fever for 14 days. Read More

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http://dx.doi.org/10.1177/0300060519834454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567750PMC
May 2019
3 Reads
1.095 Impact Factor

Is there a fundamental flaw in Canada's post-arrival immigrant surveillance system for tuberculosis?

PLoS One 2019 8;14(3):e0212706. Epub 2019 Mar 8.

Montreal Chest Institute, McGill University, Montreal, Quebec, Canada.

Background: New immigrants to Canada with a history of tuberculosis or evidence of old healed tuberculosis on chest radiograph are referred to public health authorities for medical surveillance. This ostensible public health protection measure identifies a subgroup of patients (referrals) who are at very low risk (compared to non-referrals) of transmission.

Methods: To assess whether earlier diagnosis or a different phenotypic expression of disease explains this difference, we systematically reconstructed the immigration and transmission histories from a well-defined cohort of recently-arrived referral and non-referral pulmonary tuberculosis cases in Canada. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212706PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407769PMC
November 2019
7 Reads

Prognostic value of serum macrophage migration inhibitory factor levels in pulmonary tuberculosis.

Respir Res 2019 Mar 6;20(1):50. Epub 2019 Mar 6.

Department of Tuberculosis, The first affiliated Hospital of Xinxiang Medical University, No.88, Jiankang road, Weihui, Xinxiang, 453100, China.

Background: Macrophage migration inhibitory factor (MIF) makes chemokine-like functions and plays critical roles in various inflammatory diseases. This study was designed to explore the significance of MIF serum levels in predicting the prognosis of pulmonary tuberculosis (PTB) following anti-TB treatment.

Methods: Patients diagnosed with culture-confirmed PTB without treatment were included and the serum was collected. Read More

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http://dx.doi.org/10.1186/s12931-019-1004-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402089PMC
March 2019
9 Reads

Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.

Respirology 2019 11 25;24(11):1053-1062. Epub 2019 Feb 25.

Department of Respiratory Biology, University of Cambridge, Cambridge, UK.

Bronchiectasis has historically been considered to be irreversible dilatation of the airways, but with modern imaging techniques it has been proposed that 'irreversible' be dropped from the definition. The upper limit of normal for the ratio of airway to arterial development increases with age, and a developmental perspective is essential. Bronchiectasis (and persistent bacterial bronchitis, PBB) is a descriptive term and not a diagnosis, and should be the start not the end of the patient's diagnostic journey. Read More

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http://dx.doi.org/10.1111/resp.13509DOI Listing
November 2019
14 Reads

Sensitivity and specificity of screening tools and smear microscopy in active tuberculosis case finding.

Indian J Tuberc 2019 Jan 1;66(1):99-104. Epub 2018 Jun 1.

National Tuberculosis Institute, Bangalore, Karnataka, India.

Setting: Community based five pulmonary tuberculosis (PTB) surveys among adults.

Objectives: Estimate sensitivity and specificity of screening tools for PTB and sputum microscopy.

Methods: For each survey site, we estimated sensitivity and specificity of different screening criteria and microscopy against culture; pooled estimates were obtained using Random Effects Model. Read More

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http://dx.doi.org/10.1016/j.ijtb.2018.05.015DOI Listing
January 2019
1 Read

Reasons for Donor Lungs Unsuitability After Radiographic Selection.

Exp Clin Transplant 2019 01;17(Suppl 1):120-122

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Deceased lung donation requires optimum donor care, with lung viability greatly affected by the progress of the disease leading to brain death. In this study, we searched for causes of lung unsuitability for transplant in both primary and secondary evaluations.

Materials And Methods: Primary lung evaluations included chest radiography, oxygen challenge test, and donor clinical and history examination. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O62DOI Listing
January 2019
3 Reads

Inflammatory Syndrome as the Initial Manifestation of Retroperitoneal Tuberculosis in a Pregnant Woman.

Eur J Case Rep Intern Med 2018 26;5(7):000865. Epub 2018 Jul 26.

Division of Pulmonary Diseases, Department of Internal Medicine Specialties, University Hospitals of Geneva, Switzerland.

A 20-year-old asylum seeker presented with vomiting and left thigh pain, with a biological inflammatory syndrome. Pregnancy was diagnosed. Investigations revealed a pseudo-cystic, 20-cm-long retroperitoneal abscess, biopsy of which confirmed the diagnosis of tuberculosis. Read More

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http://dx.doi.org/10.12890/2018_000865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346775PMC
July 2018
3 Reads

Primary Ewing sarcoma of the kidney.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Pathology, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, The Islamic Republic of Iran.

Primary Ewing sarcoma (ES) or primitive neuroectodermal tumour (PNET) is a rare tumour in adults and primary renal involvement is extremely rare. Patients with renal ES or PNET respond to and would benefit from conventional ES treatment according to ES study protocols. Here, we report a case of a young woman, presenting with right flank pain and haematuria. Read More

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http://dx.doi.org/10.1136/bcr-2018-227198DOI Listing
January 2019
10 Reads

Rectal adenocarcinoma presenting with thigh muscle metastasis as the only metastatic site.

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

PET/CT, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, The Islamic Republic of Iran.

Rectal carcinoma with metastasis to skeletal muscle is a rare finding. According to literature review, 17 cases of skeletal muscle metastasis from colorectal carcinoma have been documented where only six cases were rectal carcinomas.We discuss a case of a middle-aged man with a known history of high-grade mucinous adenocarcinoma of the rectum, status post abdominoperineal resection followed by adjuvant radiotherapy and chemotherapy. Read More

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http://dx.doi.org/10.1136/bcr-2018-226802DOI Listing
January 2019
8 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 06 16;132(6):767-769. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
June 2019
14 Reads

PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114).

BMC Cancer 2019 Jan 3;19(1). Epub 2019 Jan 3.

Medical School, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Background: The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging of non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.

Methods: Diagnostic test study including patients aged 18 years or older with operable stage I-III NSCLC and indication for a mediastinal lymph node biopsy. All patients underwent a 18F-FDG PET-scan before invasive mediastinal staging, either through mediastinoscopy or thoracotomy, which was considered the gold-standard. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5233-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318867PMC
January 2019
8 Reads

Retrospective Analysis of 9 Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma and Literature Review.

Med Sci Monit Basic Res 2018 Dec 24;24:233-240. Epub 2018 Dec 24.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND Primary pulmonary mucosa-associated lymphoma tissue lymphoma is rare and is often misdiagnosed because of its diverse and nonspecific clinical features. The aim of this study was to raise awareness among clinicians and to share our experience of treating and managing such patients. MATERIAL AND METHODS This retrospective study was conducted between 1 January 2009 and 31 October 2017 at the First Affiliated Hospital of Guangxi Medical University. Read More

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http://dx.doi.org/10.12659/MSMBR.912762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698091PMC
December 2018
15 Reads

Comparative study of primary pulmonary cryptococcosis with multiple nodules or masses by CT and pathology.

Exp Ther Med 2018 Dec 17;16(6):4437-4444. Epub 2018 Sep 17.

Department of Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.

The manifestations of pulmonary cryptococcosis with multiple nodules or masses on computed tomography (CT) are diverse and difficult to differentiate from those of lung cancer and pulmonary tuberculosis. The present study compared the multislice spiral CT signs with pathological results and used the pathological results to explain the CT signs with the aim of improving the accuracy of the diagnosis of this disease. A retrospective analysis of 20 patients with primary pulmonary cryptococcosis with multiple nodules or masses was performed. Read More

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http://dx.doi.org/10.3892/etm.2018.6745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257807PMC
December 2018
8 Reads

Tuberculosis of the Thyroid Gland Presented as a Rapid Enlargement of a Preexisting Goiter.

Case Rep Endocrinol 2018 12;2018:4369531. Epub 2018 Nov 12.

Department of Endocrinology, La Rabta hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Thyroid involvement with tuberculosis is an uncommon condition even in endemic countries. As its clinical presentation is not specific, diagnosis is often difficult and requires histopathological confirmation. Herein we report an observation of secondary tuberculosis of the thyroid gland in a woman with a type 2 diabetes mellitus and a primary hypothyroidism. Read More

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http://dx.doi.org/10.1155/2018/4369531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260530PMC
November 2018
38 Reads

Unrecognized and delayed to diagnose of adolescence tuberculosis case in a boarding school in West Java, Indonesia.

Int J Mycobacteriol 2018 Oct-Dec;7(4):387-389

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Adolescent is a high-risk population for developing tuberculosis (TB) disease, unfortunately adolescence TB remains to be neglected. Clinical manifestations of TB are usually chronic and nonspecific that could be mimicking other disease. Unrecognized TB disease will lead to misdiagnosis, delayed, and inappropriate management. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_149_18DOI Listing
June 2019
6 Reads

Reduced area of the normal lung on high-resolution computed tomography predicts poor survival in patients with lung cancer and combined pulmonary fibrosis and emphysema.

Respir Investig 2019 Mar 22;57(2):140-149. Epub 2018 Nov 22.

Department of Respiratory Medicine, Respiratory Centre, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan; Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan. Electronic address:

Background: This study aimed to determine the radiologic predictors and clarify the clinical features related to survival in patients with combined pulmonary fibrosis and emphysema (CPFE) and lung cancer.

Methods: We retrospectively reviewed the medical chart data and high-resolution computed tomography (HRCT) findings for 81 consecutive patients with CPFE and 92 primary lung cancers (70 men, 11 women; mean age, 70.9 years). Read More

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http://dx.doi.org/10.1016/j.resinv.2018.10.007DOI Listing
March 2019
8 Reads

High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types.

Elife 2018 11 14;7. Epub 2018 Nov 14.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, United States.

Understanding the distribution patterns of antibiotics at the site of infection is paramount to selecting adequate drug regimens and developing new antibiotics. Tuberculosis (TB) lung lesions are made of various immune cell types, some of which harbor persistent forms of the pathogen, . By combining high resolution MALDI MSI with histology staining and quantitative image analysis in rabbits with active TB, we have mapped the distribution of a fluoroquinolone at high resolution, and identified the immune-pathological factors driving its heterogeneous penetration within TB lesions, in relation to where bacteria reside. Read More

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https://elifesciences.org/articles/41115
Publisher Site
http://dx.doi.org/10.7554/eLife.41115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249001PMC
November 2018
35 Reads

Competence in pleural procedures.

Panminerva Med 2019 Sep 31;61(3):326-343. Epub 2018 Oct 31.

Division of Pneumology, Spedali Civili di Brescia, Brescia, Italy.

Diseases of the pleura and pleural space are common and present a significant contribution to the workload of respiratory physicians, with most cases resulting from congestive heart failure, pneumonia, and cancer. Although the radiographic and ultrasonographic detection of pleural abnormalities may be obvious, the determination of a specific diagnosis can often represent a challenge. Invasive procedures such as pleural drainage, ultrasound/CT-guided pleural biopsy or medical thoracoscopy can be useful in determining specific diagnosis of pleural diseases. Read More

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https://www.minervamedica.it/index2.php?show=R41Y9999N00A181
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http://dx.doi.org/10.23736/S0031-0808.18.03564-4DOI Listing
September 2019
53 Reads

Bronchial anthracofibrosis: The spectrum of radiological appearances.

Indian J Radiol Imaging 2018 Jul-Sep;28(3):333-341

Department of Imaging, Max Super Speciality Hospital, Saket, New Delhi, India.

Bronchial anthracofibrosis (BAF), caused by long-standing exposure to biomass fuel smoke, has emerged as a distinct pulmonary disease. It is usually seen in elderly females who have worked long hours in poorly ventilated kitchen full of smoke due to incomplete combustion of biomass fuel. The diagnosis is confirmed on bronchoscopic visualization of bluish-black anthracotic pigmentation along with narrowing/distortion of the affected bronchus. Read More

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http://www.ijri.org/text.asp?2018/28/3/333/242172
Publisher Site
http://dx.doi.org/10.4103/ijri.IJRI_339_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176667PMC
October 2018
83 Reads

A Young Patient with Stroke and Primary Tuberculosis.

J Neurosci Rural Pract 2018 Oct-Dec;9(4):613-615

Department of General Medicine, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

A 21-year-old woman presented with left hemiparesis, fever, dyspnea, tachycardia, and pericardial rub on examination. She was provisionally diagnosed with infective endocarditis and received the final diagnosis of the primary pulmonary tuberculosis (PTB) and extra PTB (EPTB) with pericardial effusion and thoracic lymphadenitis. Left hemiparesis due to a pontine infarct was attributed to TB with neurovasculitis. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_59_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126281PMC
October 2018
47 Reads