799 results match your criteria Primary Lung Tuberculosis Imaging

Primary pancreatic tuberculosis with a duodenal fistula in an immunocompetent young man.

Clin J Gastroenterol 2021 Jun 13. Epub 2021 Jun 13.

Department of Gastroenterology, Topiwala National Medical College, B.Y.L. Nair Ch. Hospital, Dr. A.L Nair Road, Mumbai, 400 008, Maharashtra, India.

Tuberculosis (TB) is a common disease in developing countries that can virtually affect any organ in the body. The abdomen is one of the most common sites for extra-pulmonary tuberculosis. Primary Pancreatic tuberculosis (PPTB) is rare and can be clinically elusive. Read More

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Addison's disease as a primary manifestation of extrapulmonary tuberculosis; A case report.

Indian J Tuberc 2021 Jul 6;68(3):405-407. Epub 2020 Aug 6.

Postgraduate Institute of Medicine, University of Colombo, Sri Lanka.

Tuberculosis remains an important public health problem globally. Addison's disease due to bilateral adrenal Tuberculosis as the primary manifestation of Extrapulmonary Tuberculosis is a very rare clinical entity. Previously healthy 52 years old male presented with increasing darkening of the skin, dizziness, loss of weight, loss of appetite, generalized weakness for one year and diarrhoea, vomiting for 3 months. Read More

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The silent pandemic in South Africa: Extra-pulmonary tuberculosis from head to heel.

SA J Radiol 2021 16;25(1):2026. Epub 2021 Apr 16.

Department of Medical Imaging and Clinical Oncology, Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa.

Extra-pulmonary tuberculosis (EPTB), caused by , is the leading cause of communicable disease-related deaths in people with human immunodeficiency virus (HIV) worldwide and in South Africa. disseminates haematogenously from an active primary lung focus and may affect extra-pulmonary sites in up to 15% of patients. Extra-pulmonary TB may present with a normal chest radiograph, which often causes a significant diagnostic dilemma. Read More

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Cytocompatibility and cellular interactions of chondroitin sulfate microparticles designed for inhaled tuberculosis treatment.

Eur J Pharm Biopharm 2021 Jun 8;163:171-178. Epub 2021 Apr 8.

Centre for Marine Sciences, Universidade do Algarve, 8005-139 Faro, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal. Electronic address:

Tuberculosis remains a leading cause of death, therapeutic failure being mainly due to non-compliance with prolonged treatments, often associated with severe side-effects. New therapeutic strategies are demanded and, considering that the lung is the primary site of infection, direct lung delivery of antibiotics is possibly an effective approach. Therapeutic success in this context depends on suitable carriers that reach the alveoli where Mycobacterium hosts (macrophages) reside, as well as on their ability to promote macrophage capture and intracellular accumulation of drugs. Read More

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Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial.

Lancet Respir Med 2021 Mar 16. Epub 2021 Mar 16.

The Aurum Institute, Johannesburg, South Africa; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Background: Current tuberculosis treatments leave patients with clinically significant lung injury and increased all-cause mortality post-cure. Adjunctive host-directed therapies could protect the lungs, improve long-term survival, and shorten treatment duration; however, few have been tested clinically. Therefore, we aimed to assess the safety and preliminary efficacy of four host-directed therapies for tuberculosis. Read More

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A man in his fifties with dry cough and pleural effusion.

Tidsskr Nor Laegeforen 2021 03 4;141(4). Epub 2021 Mar 4.

Background: Pulmonary tuberculosis is a major public health issue worldwide and is frequently overlooked, particularly in our part of the world. More caution with regard to symptoms could facilitate faster diagnosis, better treatment, and decreased morbidity and mortality.

Case Presentation: We describe the disease course in a middle-aged man presenting with non-productive cough, right-sided pleural effusion and fatigue. Read More

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A rare cause of secondary organising pneumonia.

BMJ Case Rep 2021 Mar 5;14(3). Epub 2021 Mar 5.

Pulmonology Department, Hospital Pedro Hispano, Matosinhos, Portugal.

Non-tuberculous mycobacterial pulmonary disease may have different clinical manifestations. We report a case of a 64-year-old woman presenting with persistent respiratory complaints, fever and radiological findings. Initially, she was diagnosed with community-acquired pneumonia, but after being submitted to an extensive investigation, including CT-guided transthoracic lung biopsy, a diagnosis of organising pneumonia (OP) was established. Read More

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When to consider tuberculosis: bronchiectasis in the elderly population.

BMJ Case Rep 2021 Mar 4;14(3). Epub 2021 Mar 4.

Respiratory Medicine, Imperial College Healthcare NHS Trust, London, UK.

In England patients aged 65 years and over experience a delay of more than 4 months between onset of symptoms and diagnosis of pulmonary TB. This report examines three cases of patients experiencing significant delays in both diagnosis and treatment. Each case had a background of bronchiectasis. Read More

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Tuberculous mycotic aneurysm of aortic arch: a case report emphasising on multidisciplinary management approach.

BMJ Case Rep 2021 Feb 18;14(2). Epub 2021 Feb 18.

Department of Infectious disease, Alabama Infectious Disease Center/Huntsville Hospital Health System, Huntsville, Alabama, USA.

Although tuberculosis (TB) is a well-known infection worldwide, the disease involvement in blood vessels, mainly aorta, is quite rare. The objective of this case report is to address the importance of a multidisciplinary approach aiming at successful treatment of tuberculosis, especially when presenting with mycotic aneurysm. We report a case of a 45-year-old woman with the history of sputum positive pulmonary TB, presenting with seizures and eventually found to have developed disseminated infection involving multiple organs, including the aorta. Read More

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February 2021

Consensus study on the health system and patient-related barriers for lung cancer management in South Africa.

PLoS One 2021 11;16(2):e0246716. Epub 2021 Feb 11.

Division of the Wits Health Consortium, Non-Communicable Diseases Research (NCDR), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Lung cancer is the highest incident cancer globally and is associated with significant morbidity and mortality particularly if identified at a late stage. Poor patient outcomes in low- and middle-income countries (LMIC's) might reflect contextual patient and health system constraints at multiple levels, that act as barriers to prevention, disease recognition, diagnosis, and treatment. Lung cancer screening, even for high-risk patients, is not available in the public health sector in South Africa (SA), where the current HIV and tuberculosis (TB) epidemics often take precedence. Read More

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February 2021

'If not TB, what could it be?' Chest X-ray findings from the 2016 Kenya Tuberculosis Prevalence Survey.

Thorax 2021 Jun 27;76(6):607-614. Epub 2021 Jan 27.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.

Background: The prevalence of diseases other than TB detected during chest X-ray (CXR) screening is unknown in sub-Saharan Africa. This represents a missed opportunity for identification and treatment of potentially significant disease. Our aim was to describe and quantify non-TB abnormalities identified by TB-focused CXR screening during the 2016 Kenya National TB Prevalence Survey. Read More

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Survival predictors of interstitial lung disease in India: Follow-up of Interstitial Lung Disease India registry.

Lung India 2021 Jan-Feb;38(1):5-11

Department of Medicine, Center for Interstitial Lung Diseases, University of Washington, Seattle, WA, USA.

Background: Predictors of survival for interstitial lung disease (ILD) in the Indian population have not been studied. The primary objective of the study was to assess the Modified-Gender Age and Physiology (M-GAP) score to predict survival in patients with ILD seen in clinical practice. We also analyzed the role of demographic and radiological characteristics in predicting the survival of patients with ILD. Read More

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January 2021

Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size.

Biomed Pharmacother 2021 Jan 30;133:110825. Epub 2020 Sep 30.

Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China; Peking University International Hospital, Beijing, China. Electronic address:

Background: Since December 2019, COVID-19 has spread to almost every corner of the world. In theory, tocilizumab and favipiravir are considered to be reliable drugs for the treatment of COVID-19 with elevated IL-6. We aimed to assess the efficacy and safety of tocilizumab combined with favipiravir in patients with COVID-19. Read More

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January 2021

Genital tb-diagnostic algorithm and treatment.

Indian J Tuberc 2020 Dec 15;67(4S):S111-S118. Epub 2020 Oct 15.

Medical Officer, Department of Obstetrics & Gynecology, Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, India.

Female genital tuberculosis (FGTB) is a common cause of infertility in India but its diagnosis remains elusive due to paucibacillary nature of disease. Traditional methods of diagnosis include demonstration of acid fast bacilli on endometrial or peritoneal biopsy or epithelioid granuloma on the biopsy or positive gene Xpert on the biopsy, but they are positive in small percentage of cases only missing diagnosis in many cases. Positive polymerase chain reaction (PCR) alone is not taken for diagnosis due to high false positivity. Read More

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December 2020

Diagnostic performance of EBUS-TBNA and its interrelation with PET-CT in patients with extra-thoracic malignancies.

Tuberk Toraks 2020 Sep;68(3):285-292

Department of Chest Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic tool for lung cancer, sarcoidosis, and suspected metastatic extra-thoracic malignancy (ETM). Patients with primary ETM often have hypermetabolic mediastinal/hilar lymph node enlargement in the PET-scan done for initial staging or post treatment followup. We aimed to determine the diagnostic performance of EBUS-TBNA and the relationship between PET-SUV values and diagnosis of malignancy metastasis in patients with ETM. Read More

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September 2020

[Often misdiagnosed primary pleural epithelioid hemangioendothelioma: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2020 Dec;49(12):1288-1293

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of primary pleural epithelioid hemangioendothelioma (EHE). Five cases of pleural EHE diagnosed from 2012 to 2019 in the Shanghai Pulmonary Hospital of Tongji University, China, were collected. They were subjected to review of clinical and image data, reevaluation of histological sections, immunohistochemistry study, clinical follow up and literature review. Read More

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December 2020

Efficacy and safety of concurrent anti-tuberculosis treatment and chemotherapy in lung cancer patients with co-existent tuberculosis.

Ann Transl Med 2020 Sep;8(18):1143

Department of Tuberculosis, Guangzhou Chest Hospital, Guangzhou, China.

Background: This retrospective study evaluated the safety and efficacy of concurrent anti-tuberculosis (TB) and chemotherapy treatment in patients with advanced lung cancer and active TB.

Methods: We retrospectively analyzed patients who were first diagnosed with advanced lung cancer and received first-line chemotherapy in Guangzhou Chest Hospital from 2015 to 2017. Patients were categorized into two groups (2:1): lung cancer patients without active TB (Group A), and lung cancer patients with active TB (Group B). Read More

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September 2020

Pregnancy in a patient with endometrial tuberculosis by in vitro fertilization: a case report.

J Int Med Res 2020 Nov;48(11):300060520967824

Jingzhou Chest Hospital, Jingzhou, China.

Female genital tuberculosis is an important cause of infertility in developing countries where tuberculosis is endemic. However, the true incidence of genital tuberculosis is unknown because symptoms and signs are usually minimal, making its detection difficult. We herein report a case of subfertility due to endometrial tuberculosis. Read More

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November 2020

Tuberculous and Brucellar Spondylodiscitis: Comparative Analysis of Clinical, Laboratory, and Radiological Features.

Asian Spine J 2020 Nov 18. Epub 2020 Nov 18.

Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.

Study Design: This was a retrospective study.

Purpose: The aim was to compare the clinical, laboratory, radiological, and evolutionary features of tuberculous spondylodiscitis (TS) and brucellar spondylodiscitis (BS).

Overview Of Literature: Clinical presentation of spondylodiscitis varies according to the underlying etiology, among which brucellosis and tuberculosis represent the primary cause, in endemic countries. Read More

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November 2020

Requests from primary care for chest X-ray and CA125 measurements during the COVID-19 emergency: An observational study.

Clin Med (Lond) 2021 Jan 13;21(1):e45-e47. Epub 2020 Nov 13.

Airedale NHS Foundation Trust, Steeton, UK.

During the first 3 months of 2020, as the COVID-19 pandemic developed, it was noticed that requests from primary care for investigations were decreasing, including those that form part of the diagnostic process for cancers. We therefore obtained data on the requests from primary care for chest X-rays (CXRs) and CA125 measurement our hospital received in the first half of 2020 and compared them with 2019. The number of CXRs declined by 93% in April 2020 compared with 2019, with the decline being greater for patient living in outlying areas. Read More

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January 2021

High yield from repeated testing for tuberculosis among high-risk citizens in Denmark.

Int J Infect Dis 2021 Jan 31;102:352-356. Epub 2020 Oct 31.

Department of Pulmonary Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Background: Screening for TB (tuberculosis) among socially marginalized citizens has been implemented in many urban areas in countries with a low incidence of TB, including Denmark. This study aims to describe the findings of the screening programs for TB and latent tuberculosis (LTBI) used in the western part of Denmark in the period 2014-2019.

Methods: Data was collected retrospectively on test results from interferon-gamma release assays (IGRA), spot sputum tests and chest X-rays performed as part of TB and LTBI screening among 1024 socially marginalized citizens in urban areas of western Denmark in 2014-2019. Read More

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January 2021

[Social stigma, chest X-radiography and primary care medicine in detection of tuberculosis cases: a case report.]

Rev Esp Salud Publica 2020 Oct 19;94. Epub 2020 Oct 19.

Médico interno residente de 4º año de Medicina Familiar y Comunitaria. Centro de Salud Justicia. Madrid. España.

Despite the scientific development of this century, tuberculosis (TB) is the most prevalent infection worldwide. For many reasons, including the social stigma associated, it is an under-diagnosed disease. About a clinical case in our practice, the purpose of this work was to give relevance to this aspect of the disease, as well as to the role of chest radiography and Primary Care Medicine in detecting and treating cases. Read More

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October 2020

Multifocal primary musculoskeletal tuberculosis in nonimmunocompromised patient from nonendemic area.

BJR Case Rep 2020 Sep 29;6(2):20190077. Epub 2020 Sep 29.

Department of Pathology, Benha University, City, Egypt.

Iliopsoas primary tuberculous abscess is a rare clinical and imaging entity. Most reported imaging literature cases are secondary to tuberculous spondylodiscitis. Iliopsoas tuberculous inflammation and abscess constitutes a diagnostic challenge owing to its insidious onset and subtle non-specific symptoms. Read More

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September 2020

Low pectoralis muscle index, cavitary nodule or mass and segmental to lobar consolidation as predictors of primary multidrug-resistant tuberculosis: A comparison with primary drug sensitive tuberculosis.

PLoS One 2020 5;15(10):e0239431. Epub 2020 Oct 5.

Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Gyeongsangnam-do, Republic of Korea.

Background: The loss of muscle mass in primary multidrug-resistant tuberculosis (MDR-TB) has not been examined in previous studies. This study aimed to investigate that low pectoralis muscle index and characteristic CT features can help differentiate patients with primary MDR-TB from those with drug-sensitive tuberculosis (DS-TB).

Material And Methods: From 2010 to 2016, we retrospectively enrolled 90 patients with primary MDR-TB and 90 age- and sex-matched patients with primary DS-TB. Read More

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November 2020

Surgical Treatment for Spinal Tuberculosis without Elevation of Inflammatory Biomarkers at the Initial Visit Mimicking Spinal Metastasis.

Case Rep Orthop 2020 25;2020:8873170. Epub 2020 Aug 25.

Department of Orthopaedic Surgery, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura City, Chiba 285-8741, Japan.

Here, we report a case of spinal tuberculosis without elevation of C-reactive protein (CRP) at the initial visit mimicking spinal metastasis. A 70-year-old woman developed progressive paraplegia without a history of injury and came to our hospital for evaluation. Severe compression to the spinal cord with osteolytic destruction of the spinal vertebrae at T6-7 was observed without elevation of CRP. Read More

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Occipital condyle syndrome in a case of rotatory atlantoaxial subluxation (type II) with craniovertebral junction tuberculosis: Should we operate on "active tuberculosis?"

J Craniovertebr Junction Spine 2020 Apr-Jun;11(2):143-147. Epub 2020 Jun 5.

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Tuberculosis of the craniovertebral junction is rare as well as intriguing. We present a unique amalgamation of three rare entities: craniovertebral tuberculosis, occipital condyle syndrome, and nontraumatic type II rotatory atlantoaxial dislocation in one patient. We reviewed the limited literature available and the underlying pathophysiology to highlight the pattern of the disease presentation, progression, and response to management options. Read More

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Promising effects of tocilizumab in COVID-19: A non-controlled, prospective clinical trial.

Int Immunopharmacol 2020 Nov 4;88:106869. Epub 2020 Aug 4.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The clinical presentation of SARS-CoV-2 infection ranges from mild symptoms to severe complications, including acute respiratory distress syndrome. In this syndrome, inflammatory cytokines are released after activation of the inflammatory cascade, with the predominant role of interleukin (IL)-6. The aim of this study was to evaluate the effects of tocilizumab, as an IL-6 antagonist, in patients with severe or critical SARS-CoV-2 infection. Read More

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November 2020

Hepatic tuberculosis masquerading as cholangiocarcinoma: an unusual differential for a liver mass.

J Surg Case Rep 2020 Aug 27;2020(8):rjaa247. Epub 2020 Aug 27.

Department of Surgery, Townsville University Hospital, Townsville 4814, Australia.

A 54-year-old woman presented with an incidentally identified asymptomatic liver lesion with imaging characteristics suspicious for malignancy. She underwent a left hemihepatectomy for presumed cholangiocarcinoma. Histopathology revealed granulomas with microbiological investigations later revealing a diagnosis of isolated hepatic tuberculosis. Read More

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Extramedullary haematopoiesis presenting as a periportal mass.

BMJ Case Rep 2020 Jul 22;13(7). Epub 2020 Jul 22.

Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran

Extramedullary haematopoiesis (EMH) is defined as haematopoiesis occurring in organs outside the bone marrow. The liver is one of the rare sites of EMH, and to the best of our knowledge, a few cases of adult EMH of the liver have been reported in the last 20 years. Here, we reported the case of a 68-year-old man with a known history of myelofibrosis presented with vague abdominal pain. Read More

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Case Report: The First Direct Evidence of Migration through Human Lung.

Am J Trop Med Hyg 2020 09;103(3):1129-1134

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Gnathostomiasis is a helminthic infection caused by the third-stage larvae of nematodes of the genus . The life cycle in humans starts with an enteric phase, with the worm perforating the gastric or intestinal mucosa to reach the peritoneal cavity and migrating through the human body. Subsequent penetration through the diaphragm may produce pleuropulmonary symptoms. Read More

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September 2020