13,690 results match your criteria Primary Insomnia


Clinical Characteristics of Obstructive Sleep Apnea in Psychiatric Disease.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

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http://dx.doi.org/10.3390/jcm8040534DOI Listing

Cannabis Use among Patients in a Rural Academic Palliative Care Clinic.

J Palliat Med 2019 Apr 17. Epub 2019 Apr 17.

1 Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.

Therapeutic cannabis is being more widely used by patients to manage multiple symptoms, but the patterns of use in the palliative care population are not well defined. The primary aim of this pilot study was to describe the use of cannabis among patients attending a palliative care clinic (PCC). The study was a retrospective chart review of patients seen at four different interval points during 2017 and 2018 in an ambulatory palliative care setting. Read More

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http://dx.doi.org/10.1089/jpm.2018.0534DOI Listing
April 2019
3 Reads

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

Cochrane Database Syst Rev 2019 Apr 12;4:CD012680. Epub 2019 Apr 12.

School of Psychology, Deakin University Geelong, 221 Burwood Highway, Burwood, VIC, Victoria, Australia, 3025.

Background: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical symptoms of IBD. Read More

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http://doi.wiley.com/10.1002/14651858.CD012680.pub2
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http://dx.doi.org/10.1002/14651858.CD012680.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459769PMC
April 2019
2 Reads

Effectiveness of Internet-Delivered Computerized Cognitive Behavioral Therapy for Patients With Insomnia Who Remain Symptomatic Following Pharmacotherapy: Randomized Controlled Exploratory Trial.

J Med Internet Res 2019 Apr 11;21(4):e12686. Epub 2019 Apr 11.

Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: In reality, pharmacotherapy still remains the most common treatment for insomnia.

Objective: This study aimed to examine the effectiveness of our internet-delivered computerized cognitive behavioral therapy (ICBT) program as an adjunct to usual care (UC) compared with UC alone in patients with insomnia who remain symptomatic following hypnotics.

Methods: We recruited 23 patients with insomnia who remained symptomatic following pharmacologic treatment including benzodiazepines, and we conducted an exploratory randomized controlled trial. Read More

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http://dx.doi.org/10.2196/12686DOI Listing
April 2019
2 Reads

Cognitive Behavioral Therapy for Prenatal Insomnia: A Randomized Controlled Trial.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Stanford University, Stanford, California; Monash University, Melbourne, Australia; and Santa Clara Valley Medical Center, Fruitdale, California.

Objective: To evaluate the effectiveness of cognitive behavioral therapy for insomnia during pregnancy.

Methods: Randomized, unmasked, 3-site controlled trial. Participants were randomly allocated to cognitive behavioral therapy for insomnia (a first-line, empirically supported psychosocial intervention that addresses sleep-related behaviors and cognitions) or a control intervention consisting of imagery exercises that paired patient-identified distressing nighttime experiences with patient-identified neutral images. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003216DOI Listing
April 2019
1 Read

Employee Sleep and Workplace Health Promotion: A Systematic Review.

Am J Health Promot 2019 Apr 7:890117119841407. Epub 2019 Apr 7.

3 Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.

Objective: Workplace-based employee health promotion programs often target weight loss or physical activity, yet there is growing attention to sleep as it affects employee health and performance. The goal of this review is to systematically examine workplace-based employee health interventions that measure sleep duration as an outcome.

Data Source: We conducted systematic searches in PubMed, Web of Knowledge, EMBASE, Scopus, and PsycINFO (n = 6177 records). Read More

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http://dx.doi.org/10.1177/0890117119841407DOI Listing
April 2019
2 Reads

The Epworth Sleepiness Scale in Service Members with Sleep Disorders.

Mil Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Sleep Medicine, San Antonio Uniformed Services Health Education Consortium, San Antonio, TX.

Introduction: Excessive daytime sleepiness affects an estimated 20% of the general population. While the prevalence of sleepiness in the military is largely unknown, it is well established that short sleep duration is endemic. The reasons for this include: the demanding nature of their duties, shift work and 24-hour duty periods, deployments and exigencies of military service as well as sleep disorders. Read More

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http://dx.doi.org/10.1093/milmed/usz066DOI Listing
April 2019
1 Read

A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol.

Internet Interv 2019 Sep 10;17:100236. Epub 2019 Feb 10.

Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.

Background: Internet-delivered interventions can provide remarkable opportunities in addressing breast cancer survivors' unmet support care needs, as they present an effective strategy to improve care coordination and provide access to efficacious, cost-efficient and convenient survivorship care. Nevertheless, research focusing on improving survivors' psychosocial needs using internet-based tools is scarce and its practical implementation is limited.

Objectives: To study the acceptability, feasibility, efficacy and cost-effectiveness of iNNOVBC, a 10 weeks guided internet-delivered individually-tailored Acceptance and Commitment Therapy (ACT)-influenced cognitive behavioural (CBT) intervention developed to improve mild to moderate anxiety and depression in Breast cancer survivors when compared to treatment as usual (TAU) in a waiting list control group (WLC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22147829183007
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http://dx.doi.org/10.1016/j.invent.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430035PMC
September 2019
3 Reads

[Clinical Validation of The Portuguese Version of the Children's Sleep Habits Questionnaire (CSHQ-PT) in Children with Sleep Disorder and ADHD].

Acta Med Port 2019 Mar 29;32(3):195-201. Epub 2019 Mar 29.

Unidade de Neurodesenvolvimento. Centro da Criança e do Adolescente. CUF Descobertas Hospital. Lisboa. Portugal.

Introduction: The Portuguese version of the Children's Sleep Habits Questionnaire showed adequate psychometric properties in a community sample but the American cut-off seemed inadequate. This study aimed to validate this questionnaire in clinical populations of children with sleep disorders and with attention deficit/ hyperactivity disorder.

Material And Methods: The study sample included 148 Portuguese children aged 2 to 10 years old that where divided in 3 groups: 1. Read More

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http://dx.doi.org/10.20344/amp.10906DOI Listing
March 2019
5 Reads

Experience of a Portuguese Center: Effectiveness of Direct-Acting Antiviral Therapy for Hepatitis C.

Acta Med Port 2019 Mar 29;32(3):189-194. Epub 2019 Mar 29.

Pharmacy and Therapeutics Committee. Centro Hospitalar de Lisboa Ocidental. Lisboa. Portugal.

Introduction: In late 2014, Portugal implemented a national program for the treatment of patients with chronic hepatitis C with directacting antiviral agents. This program has made Portugal one of the first European countries to implement a structured measure of treatment to eliminate this serious public health problem. The aim of this study was to assess the effectiveness of direct-acting antiviral therapy in the treatment of patients with chronic hepatitis C virus infection. Read More

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http://dx.doi.org/10.20344/amp.10655DOI Listing
March 2019
1 Read

A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):203-209

H. Lundbeck A/S, Valby, Denmark.

Background: Long-term treatment is recommended in major depressive disorder (MDD) to prevent relapse and to restore functioning. The aim of this study (Orion; NCT01360866) was to assess the long-term safety, tolerability, and efficacy of open-label treatment with adjunctive brexpiprazole in adult patients with MDD.

Methods: Patients rolled over into this 52-week study (amended to 26 weeks) from 3 randomized, double-blind, placebo-controlled studies. Read More

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http://Insights.ovid.com/crossref?an=00004714-900000000-9857
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http://dx.doi.org/10.1097/JCP.0000000000001034DOI Listing
April 2019
10 Reads

Zao Ren An Shen capsule for chronic insomnia: Study protocol for a randomized, placebo-controlled trial.

Medicine (Baltimore) 2019 Apr;98(14):e14853

School of Science and Health, NICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.

Background: Zao Ren An Shen (ZRAS), a Chinese Herbal Medicine product, has been proposed as an alternative to recommended treatments for chronic insomnia. There is a lack of strong evidence supporting this proposition.

Aims: To assess the efficacy and safety of ZRAS capsule for chronic insomnia compared to placebo. Read More

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http://dx.doi.org/10.1097/MD.0000000000014853DOI Listing
April 2019
2 Reads

Efficacy of individualized homeopathic treatment of insomnia: Double-blind, randomized, placebo-controlled clinical trial.

Complement Ther Med 2019 Apr 9;43:53-59. Epub 2019 Jan 9.

93/2/1, Shibpur Road, PO and PS Shibpur, Howrah 711102, West Bengal, India. Electronic address:

Background: Insomnia is the most common sleep-related complaint associated with impaired day-time functioning, reduced quality of life, increased morbidity and substantial societal cost. We evaluated whether individualized homeopathy (IH) could produce significant effect beyond placebo in treatment of insomnia.

Methods: In this double-blind, randomized, placebo-controlled, two parallel arms trial, 60 patients were randomized to receive either IH/verum or control/placebo (1:1). Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.007DOI Listing
April 2019
5 Reads
2.216 Impact Factor

Primary insomnia patients' performances during simulated car following and urban driving in the afternoon.

J Sleep Res 2019 Mar 31:e12847. Epub 2019 Mar 31.

Normandie Univ, UNICAEN, INSERM, COMETE, 14000, Caen, France.

According to epidemiological studies, insomnia is associated with an increase in risk of traffic accidents. Recent investigations revealed that patients with insomnia had driving performance impairment under monotonous conditions. However, it is unclear whether other driving abilities may be impacted by insomnia, especially those needing more attentional resources than those involved in monotonous driving. Read More

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http://dx.doi.org/10.1111/jsr.12847DOI Listing
March 2019
2 Reads

Effects of Integrated Telehealth-Delivered Cognitive-Behavioral Therapy for Depression and Insomnia in Rural Older Adults.

J Psychother Integr 2018 Sep;28(3):292-309

Alabama Neurology and Sleep Medicine, Tuscaloosa, AL.

Background: We examined the effects of integrated cognitive-behavioral therapy for depression and insomnia (CBT-D + CBT-I) delivered via videoconferening in rural, middle aged and older adults with depressive and insomnia symptoms.

Method: Forty patients with depressive and insomnia symptoms were randomized to receive either 10 sessions of CBT-D + CBT-I or usual care (UC). Patients in the integrated CBT condition were engaged in telehealth treatment through Skype at their primary care clinic. Read More

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http://dx.doi.org/10.1037/int0000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437761PMC
September 2018
3 Reads

Brief mindfulness-based stress management program for a better mental state in working populations - Happy Nurse Project: A randomized controlled trial.

J Affect Disord 2019 Mar 22;251:186-194. Epub 2019 Mar 22.

Departments of Health Promotion and Human Behavior and of Clinical Epidemiology, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan. Electronic address:

Background: The efficacy of the mindfulness-based stress management program for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of the brief mindfulness-based stress management program for hospital nurses.

Methods: In a multi-center randomized trial, 80 junior nurses working in hospitals were randomly allocated either to the brief mindfulness-based stress management program or psychoeducation using a leaflet. Read More

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http://dx.doi.org/10.1016/j.jad.2019.03.067DOI Listing
March 2019
1 Read

Sleep Disturbance in Adjustment Disorder and Depressive Episode.

Int J Environ Res Public Health 2019 Mar 26;16(6). Epub 2019 Mar 26.

Department of Adult Psychiatry, UCD School of Medicine and Medical Science, University College Dublin, Mater Misericordiae University Hospital, 62/63 Eccles Street, 7 Dublin, Ireland.

In this paper, we aimed to examine the patterns of sleep disturbance in adjustment disorder (AD) and depressive episode (DE), to examine the variables associated with sleep disturbance in AD and DE and associated impairment in functioning. This is a multi-centre case-control study of 370 patients: 185 patients with AD and 185 patients with a diagnosis of DE, recruited from the liaison psychiatry services of three Dublin hospitals. We examined the participants' sleep pathology using the sleep disturbance items on the Schedule for Clinical Assessment in Neuropsychiatry, and the Inventory of Depressive Symptoms-Clinician-rated-30. Read More

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http://dx.doi.org/10.3390/ijerph16061083DOI Listing
March 2019
1 Read

Cognitive Behavioral Therapy for Insomnia in Alcohol Dependent Veterans: A Randomized, Controlled Pilot Study.

Alcohol Clin Exp Res 2019 Mar 26. Epub 2019 Mar 26.

Cpl. Michael J. Crescenz VA Medical Center, Philadelphia, PA.

Background: Insomnia is highly prevalent in individuals recovering from Alcohol Dependence (AD) and increases their risk of relapse. Two studies evaluating Cognitive Behavioral Therapy for Insomnia (CBT-I) have demonstrated its efficacy in non-Veterans recovering from AD. The aim of this study was to extend these findings in an 8-week trial of CBT-I in Veterans. Read More

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http://dx.doi.org/10.1111/acer.14030DOI Listing
March 2019
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"You're Missing Out on Something Great": Patient and Provider Perspectives on Increasing the Use of Cognitive Behavioral Therapy for Insomnia.

Behav Sleep Med 2019 Mar 24:1-14. Epub 2019 Mar 24.

d Jennifer Wisdom Consulting , New York , New York.

Objective/background: Cognitive behavioral therapy for insomnia (CBT-I) is the most effective treatment for insomnia but is severely underutilized. One of the key reasons for underuse is lack of knowledge among patients and primary care providers, but effective methods and materials for increasing knowledge are unknown. This study conducted in-depth interviews with CBT-I patients and their CBT-I providers to explore their perceptions on increasing utilization of CBT-I. Read More

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http://dx.doi.org/10.1080/15402002.2019.1591958DOI Listing
March 2019
6 Reads

Subtyping insomnia disorder - Authors' reply.

Lancet Psychiatry 2019 04;6(4):285-286

Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, Netherlands; Department of Integrative Neurophysiology and Department of Psychiatry, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam University Medical Centre, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(19)30079-3DOI Listing
April 2019
1 Read

Subtyping insomnia disorder.

Lancet Psychiatry 2019 04;6(4):284

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology, Sleep Disorders Center, Milan, Italy; Vita-Salute San Raffaele University, Faculty of Psychology, Milan, Italy.

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http://dx.doi.org/10.1016/S2215-0366(19)30098-7DOI Listing
April 2019
1 Read

Subtyping insomnia disorder.

Lancet Psychiatry 2019 04;6(4):284-285

Department of Neuropsychiatry, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan. Electronic address:

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http://dx.doi.org/10.1016/S2215-0366(19)30083-5DOI Listing
April 2019
2 Reads

Use of a Wearable Technology and Motivational Interviews to Improve Sleep in Older Adults With Osteoarthritis and Sleep Disturbance: A Pilot Study.

Res Gerontol Nurs 2019 Mar 22:1-7. Epub 2019 Mar 22.

The feasibility and preliminary efficacy of a mobile health self-management intervention aimed at improving sleep among older adults with osteoarthritis and disturbed sleep were evaluated. This was a one-group pre-/posttest pilot study. Feasibility was measured by the number of participants eligible, enrolled, and retained. Read More

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http://dx.doi.org/10.3928/19404921-20190319-02DOI Listing
March 2019
4 Reads

Second-generation antidepressants for preventing seasonal affective disorder in adults.

Cochrane Database Syst Rev 2019 03 18;3:CD011268. Epub 2019 Mar 18.

Cochrane Austria, Department for Evidence-based Medicine and Clinical Epidemiology, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, Krems, Austria, 3500.

Background: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. Read More

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http://dx.doi.org/10.1002/14651858.CD011268.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422318PMC
March 2019
1 Read

Non-pharmacological and pharmacological interventions relieve insomnia symptoms by modulating a shared network: A controlled longitudinal study.

Neuroimage Clin 2019 Mar 4;22:101745. Epub 2019 Mar 4.

Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA. Electronic address:

Background: Primary insomnia (PI) is one of the most common complaints among the general population. Both non-pharmacological and pharmacological therapies have proven effective in treating primary insomnia. However, the underlying mechanism of treatment remains unclear, and no studies have compared the underlying mechanisms of different treatments. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423470PMC
March 2019
1 Read

Effect of suvorexant on nighttime blood pressure in hypertensive patients with insomnia: The SUPER-1 study.

J Clin Hypertens (Greenwich) 2019 Mar 15. Epub 2019 Mar 15.

Jichi Medical University School of Medicine, Tochigi, Japan.

Orexins are neuropeptides that play a role in maintaining wakefulness and contribute to central regulation of cardiovascular function. This first multicenter, randomized, double-blind study investigated the effects of suvorexant, a reversible dual orexin receptor antagonist, on nighttime blood pressure (BP) in patients with insomnia and hypertension. After a 4-week run-in period, adult outpatients (n = 82) with treated hypertension (clinic SBP <160 mm Hg) and insomnia were treated with suvorexant 20 mg/d or placebo before bedtime for 2 weeks. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jch.13505
Publisher Site
http://dx.doi.org/10.1111/jch.13505DOI Listing
March 2019
13 Reads

Association between mandibular advancement device therapy and reduction of Excessive Daytime Sleepiness due to Obstructive Sleep Apnea.

J Oral Rehabil 2019 Mar 15. Epub 2019 Mar 15.

Department of Prosthodontics and Periodontology. Piracicaba Dental School, UNICAMP, Av Limeira 901, Piracicaba, SP, Brazil, 13414-903.

Background: Excessive daytime sleepiness is frequently reported as a symptom for OSA, leading to problems with concentration, mood and memory. MAD are considered as an effective therapy to control OSA, reducing EDS and improving sleep quality.

Objectives: The present study aimed to investigate the effects of mandibular advance device (MAD) therapy on excessive daytime sleepiness (EDS) of patients diagnosed with obstructive sleep apnea (OSA). Read More

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http://dx.doi.org/10.1111/joor.12792DOI Listing
March 2019
4 Reads

Repetitive transcranial magnetic stimulation (rTMS) modulates time-varying electroencephalography (EEG) network in primary insomnia patients: a TMS-EEG study.

Sleep Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China. Electronic address:

Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method, and its application in the treatment of primary insomnia (PI) is poorly researched. PI is considered to be a functional disorder with abnormal brain network connections. TMS combined electroencephalography (EEG) is a valuable method for directly probing excitability and dynamic connectivity of different regions in the brain. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.007DOI Listing
January 2019
2 Reads
3.154 Impact Factor

Insomnia treatment response as a function of objectively measured sleep duration.

Sleep Med 2019 Jan 31. Epub 2019 Jan 31.

École de psychologie, Université Laval, Québec, QC, Canada; Centre de recherche CERVO, Québec, QC, Canada. Electronic address:

Objectives: To examine the potential moderating effect of objectively measured sleep duration at baseline on the response to cognitive behavioral therapy for insomnia (CBT-I), administered singly or combined with medication (CBT-I + Med).

Methods: Based on the average PSG-derived sleep duration across two baseline nights and the type of treatment received, 159 adults with insomnia (50.3 ± 10. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.016DOI Listing
January 2019
3 Reads

Pediatric sleep disturbances and treatment with melatonin.

J Transl Med 2019 Mar 12;17(1):77. Epub 2019 Mar 12.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129, Perugia, Italy.

Background: There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the efficacy and safety of melatonin in treating pediatric insomnia and sleep disturbances.

Main Body: Sleep disturbances are highly prevalent in children and, without appropriate treatment, can become chronic and last for many years; however, distinguishing sleep disturbances from normal age-related changes can be a challenge for physicians and may delay treatment. Read More

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http://dx.doi.org/10.1186/s12967-019-1835-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419450PMC
March 2019
4 Reads

Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.

J Food Sci 2019 Apr 13;84(4):904-910. Epub 2019 Mar 13.

Xiangya Hospital, Central South Univ., Changsha, China.

Imatinib, the prototype BCR-ABL tyrosine kinase inhibitor (TKI), is the first-line treatment for Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase. However, a subgroup of patients exhibit poor response or experience relapse. This issue may be overcome by combination therapy using natural compounds. Read More

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http://dx.doi.org/10.1111/1750-3841.14484DOI Listing
April 2019
2 Reads

88 The Efficacy and Safety of Amphetamine Extended-Release Oral Suspension (AMPH EROS) in Children with Attention-Deficit/Hyperactivity Disorder.

CNS Spectr 2019 Feb;24(1):219-220

Tris Pharma,Inc.,Monmouth Junction,NJ.

OBJECTIVESTo determine the efficacy and safety of amphetamine extended-release oral suspension (AMPH EROS) in the treatment of attention-deficit/hyperactivity disorder (ADHD) compared with placebo in a dose-optimized, randomized, double-blind study.METHODSThe efficacy of AMPH EROS was evaluated in a laboratory classroom study conducted in 108 pediatric patients (aged 6-12 years) with ADHD. The study began with an open-label dose optimization (5weeks) with an initial AMPH EROS dose of 2. Read More

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http://dx.doi.org/10.1017/S109285291900066XDOI Listing
February 2019
1 Read

87 Efficacy Measures in an Open-label Dose-Optimization of an Amphetamine Extended-Release Oral Suspension in Children with Attention-Deficit/Hyperactivity Disorder.

CNS Spectr 2019 Feb;24(1):218-219

1Meridien Research,Bradenton,FL.

Objectives: Report the efficacy of open-label amphetamine extended-release oral suspension (AMPH EROS) for the treatment of children with ADHD.AMPH EROS has a 1-hr onset of effect and a duration of action of 13hours and was approved by FDA for treatment of ADHD in children aged 6-17 years based on a double-blind, placebo-controlled efficacy and safety study in children aged 6-12 years with ADHD. A significant treatment difference in change from pre-dose SKAMP-combined score was observed at the primary endpoint of 4hours post-dose (p5%) reported during dose optimization were decreased appetite, insomnia, affect lability, upper abdominal pain, mood swings and headache. Read More

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http://dx.doi.org/10.1017/S1092852919000658DOI Listing
February 2019
1 Read

[Prevalence of insomnia and characteristic of patients with insomnia in a health area of Majorca (Spain)].

Aten Primaria 2019 Mar 8. Epub 2019 Mar 8.

Unidad Docente Multiprofesional de Atención Familiar y Comunitaria, Gerencia de Atención Primaria de Mallorca, Ibsalut, Islas Baleares, España; Instituto de Investigación Sanitaria de las Islas Baleares (idISBA), Palma de Mallorca, Islas Baleares.

Objectives: To estimate insomnia prevalence as well as habits comorbidity, sleep quality of insomnia patients.

Design: Cross sectional descriptive study.

Setting: Calvia health center (Majorca, Spain). Read More

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http://dx.doi.org/10.1016/j.aprim.2018.02.014DOI Listing
March 2019
1 Read

Predictive factors of sleep quality in patients with chronic migraine.

Neurologia 2019 Mar 8. Epub 2019 Mar 8.

Departamento de Fisioterapia, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Motion in Brains Research Group, Institute of Neuroscience and Sciences of the Movement (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, España; Instituto de Neurociencia y Dolor Craneofacial (INDCRAN), Madrid, España; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, España.

Introduction: One of the factors contributing to transformation of migraine are sleep disorders, which can act as a trigger and/or perpetuating factor in these patients. This study's primary objective was to identify predictive factors related to sleep quality in patients with chronic migraine (CM); the secondary objective was to identify any differences in psychological variables and disability between patients with CM with better or poorer sleep quality.

Methods: A total of 50 patients with CM were included in an observational, cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.nrl.2018.11.004DOI Listing
March 2019
1 Read

Study on the Differences between Traditional Chinese Medicine Syndromes in NYHA I-IV Classification of Chronic Heart Failure.

Evid Based Complement Alternat Med 2019 3;2019:2543413. Epub 2019 Feb 3.

Beijing University of Chinese Medicine (Institute of Traditional Chinese Medicine; Beijing Key Laboratory of TCM Syndrome and Formula; Ministry of Education Key Laboratory of TCM Syndrome and Formula), Bei San Huan Dong Lu, Chao Yang District, Beijing 100029, China.

Objectives: This study investigated the distribution of characteristics of traditional Chinese medicine syndromes and their association with symptoms in 1027 patients with chronic heart failure (CHF).

Methods: An observational study was performed by researchers, collecting data from 1036 patients with CHF from 24 Chinese medicine hospitals from May 2009 to December 2014. Due to incomplete information from nine patients, 1027 patients with CHF were analysed. Read More

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http://dx.doi.org/10.1155/2019/2543413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378041PMC
February 2019
1 Read
1.880 Impact Factor

Reducing burnout and anxiety among doctors: Randomized controlled trial.

Psychiatry Res 2019 04 1;274:383-390. Epub 2019 Mar 1.

Birkbeck Centre for Medical Humanities, Birkbeck, University of London, London, UK.

Prevalence studies show high levels of burnout, anxiety, fatigue and other symptoms of distress among medical doctors. However, there are very few randomized controlled trials testing interventions against these problems. This randomized controlled trial (NCT02838290; ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.075DOI Listing
April 2019
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Insomnia in pediatric obsessive-compulsive disorder: prevalence and association with multimodal treatment outcomes in a naturalistic clinical setting.

Sleep Med 2019 Jan 30. Epub 2019 Jan 30.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

Objective: Little is known about the prevalence and impact of insomnia on clinical outcomes in youth with obsessive-compulsive disorder (OCD). This study aimed to investigate this subject.

Patients/methods: A total of 193 patients from a specialist pediatric OCD clinic completed a range of diagnostic and clinical measures, including the Insomnia Severity Index (ISI). Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.024DOI Listing
January 2019
1 Read

Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety.

Brain Behav Immun 2019 Mar 6. Epub 2019 Mar 6.

Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Objective: Circadian dysfunction is a core manifestation and a risk factor for psychiatric disorders. Ramelteon (RMT), a melatonin receptor agonist, has been shown to induce sleep phase shifts and has been used to normalize sleep onset time. RMT has been used in sleep disorders, depression and anxiety. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.003DOI Listing
March 2019
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Insomnia severity index: a psychometric investigation among Saudi nurses.

Sleep Breath 2019 Mar 8. Epub 2019 Mar 8.

Department of Nursing, College of Applied Medical Sciences, Majmaah University, Al Majmaah, 11952, Saudi Arabia.

Background: Insomnia is the most prevalent sleep disorder, but it is widely untreated and under-diagnosed in Saudi Arabia. Moreover, no tool to screen insomnia has been validated in the Saudi population in general or nurses in particular. This study, therefore, assessed the psychometric validity of the Insomnia Severity Index (ISI) in Saudi nurses. Read More

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http://dx.doi.org/10.1007/s11325-019-01812-8DOI Listing
March 2019
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Serotonin and Norepinephrine Reuptake Inhibitors.

Handb Exp Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

University of Alabama at Birmingham, Birmingham, AL, USA.

This chapter covers antidepressants that fall into the class of serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors. That is, they bind to the 5-HT and NE transporters with varying levels of potency and binding affinity ratios. Unlike the selective serotonin (5-HT) reuptake inhibitors (SSRIs), most of these antidepressants have an ascending rather than a flat dose-response curve. Read More

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http://dx.doi.org/10.1007/164_2018_164DOI Listing
March 2019
9 Reads

[Psychological characteristics in different clinical subgroups of insomniacs].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):186-192

Psychosomatic Health Institute, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objective: To investigate psychological characteristics in different clinical subgroups of insomniacs, and to provide the basis for the accurate simplification of cognitive behavioral therapy for insomnia.
 Methods: A total of 212 insomniacs from November 2014 to June 2017 in Clinical Psychology Department or Sleep Department of 2 general hospitals in Hunan Province were included in convenient and classified into sleep onset insomnia (SOI), difficulty maintaining insomnia (DMI), early morning awakening insomnia (EMAI), and combined insomnia (CI) subgroups. Ford Insomnia Response to Stress Test (FIRST), Simplified Coping Style Questionnaire (SCSQ), Dysfunctional Beliefs and Attitudes about Sleep Scale 16 version (DBAS-16), Sleep-Related Behavior Questionnaire (SRBQ), Pre-sleep Arousal Scale (PSAS), Center for Epidemiological Studies Depression Scale (CES-D), Beck Anxiety Inventory (BAI) were used to investigate the psychological characteristics. Read More

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February 2019
4 Reads

Solving insomnia electronically: Sleep treatment for asthma (SIESTA): A study protocol for a randomized controlled trial.

Contemp Clin Trials 2019 Apr 27;79:73-79. Epub 2019 Feb 27.

School of Nursing, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

Background: Chronic insomnia is associated with poor asthma control. Cognitive-behavioral treatment for insomnia (CBT-I) is an efficacious and durable treatment for comorbid insomnia in medical and psychiatric disorders. However, the efficacy and potential accompanying mechanisms of CBT-I have not been examined in asthma. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.011DOI Listing
April 2019
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Randomized, double-blind, placebo-controlled study of F17464, a preferential D antagonist, in the treatment of acute exacerbation of schizophrenia.

Neuropsychopharmacology 2019 Mar 1. Epub 2019 Mar 1.

Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, Toulouse, 31000, France.

F17464, a highly potent preferential D3 antagonist, is a novel compound in development for schizophrenia treatment. This phase II, double-blind, randomized, placebo-controlled, parallel-group study in five European countries evaluated the efficacy and safety of F17464, 20 mg twice daily, versus placebo over 6 weeks in patients with acute exacerbation of schizophrenia. Change from baseline to Day 43 of the Positive and Negative Syndrome Scale (PANSS) total score was the primary outcome. Read More

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http://www.nature.com/articles/s41386-019-0355-2
Publisher Site
http://dx.doi.org/10.1038/s41386-019-0355-2DOI Listing
March 2019
8 Reads

Responses of lung cancer survivors undergoing gamma knife surgery to supportive group psychotherapy.

Medicine (Baltimore) 2019 Mar;98(9):e14693

Radiotherapy Center, No. 323 Hospital of People's Liberation Army, Xi'an, China.

An increasingly important concern for clinicians who care for patients with cancers is their psychological problems and quality of life. The present study examined the efficacy of supportive group psychotherapy (SGP) on anxiety, depression and overall quality of life in patients with lung cancer undergoing gamma knife surgery (GKS).160 patients with lung cancer undergoing GKS were randomly divided into SGP group (n = 82) and care as usual (CAU) group (n = 78). Read More

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http://dx.doi.org/10.1097/MD.0000000000014693DOI Listing
March 2019
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Auriculotherapy for sleep quality in people with primary insomnia: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Feb;98(8):e14621

Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Background: Primary insomnia is one of the common sleep disorders. Auriculotherapy originated from traditional Chinese medicine, has been thought as a promising treatment for primary insomnia. We aim to evaluate the efficacy and safety of auriculotherapy for patients with primary insomnia through this systematic review. Read More

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http://dx.doi.org/10.1097/MD.0000000000014621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408129PMC
February 2019
3 Reads
5.723 Impact Factor

The effect of cognitive behavioral therapy for insomnia in schizophrenia patients with sleep Disturbance: A non-randomized, assessor-blind trial.

Psychiatry Res 2019 04 3;274:182-188. Epub 2019 Feb 3.

Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Republic of Korea. Electronic address:

This non-randomized, assessor blind study evaluated the effects of cognitive behavioral therapy for insomnia (CBT-I) delivered in a group format on insomnia symptoms as well as psychotic, depressive, and anxiety symptoms in schizophrenia patients (n = 63) recruited from residential or rehabilitative facilities in Seoul, South Korea. Thirty-one patients received four sessions of CBT-I in groups of 2-9 patients in addition to usual care, while the control group (n = 32) received no additional intervention. The Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI), Psychotic Symptoms Rating Scale (PSYRATS), Anxiety Sensitivity Index (ASI), and Beck Depression Inventory (BDI) were administered at baseline, week 4, and week 8. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.002DOI Listing

Examination of sleep health dimensions and their associations with perceived stress and health in a UK sample.

J Public Health (Oxf) 2019 Feb 23. Epub 2019 Feb 23.

Department of Psychology, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Background: Sleep health is a relatively new multidimensional concept, however, there is no consensus on its underlying dimensions. A previous study examined potential indicators of sleep health using an aggregated sleep health measure. However, the psychometric properties are yet to be determined. Read More

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http://dx.doi.org/10.1093/pubmed/fdz016DOI Listing
February 2019
2 Reads

Drug treatment strategies for insomnia in patients with post-traumatic stress disorder.

Expert Opin Pharmacother 2019 Apr 22;20(6):691-699. Epub 2019 Feb 22.

b Department of Medicine , VA Western New York Healthcare System , Buffalo , NY , USA.

Introduction: Insomnia is among the most reported sleep disturbances in patients with post-traumatic stress disorder (PTSD). The pervasiveness of this disorder among trauma-inflicted civilians and military personnel has been associated with reduced quality of life, impaired psychosocial functioning including cognitive impairments, negative mood swings, cardiovascular complications, and increased utilization of medical services. Areas covered: This review describes the current state of science with respect to the impact of the most dispensed pharmacological interventions for posttraumatic insomnia. Read More

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http://dx.doi.org/10.1080/14656566.2019.1574745DOI Listing
April 2019
4 Reads