16,479 results match your criteria Primary Insomnia

Long-term Efficacy and Tolerability of Adjunctive Aripiprazole for Major Depressive Disorder: Systematic Review and Meta-analysis.

Prim Care Companion CNS Disord 2021 Jun 24;23(4). Epub 2021 Jun 24.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.

To assess the long-term efficacy and safety of aripiprazole as an augmentation strategy for major depressive disorder (MDD).

Ovid MEDLINE, PsycInfo, and Embase databases were systematically searched for clinical studies of adult patients with MDD on long-term aripiprazole augmentation.

Long-term follow-up was defined as ≥ 6 months. Read More

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Setting Objective Clinical Assessment Tools for Circadian Rhythm Sleep-Wake Disorders - A Community-Based Cross-Sectional Epidemiological Study.

Nat Sci Sleep 2021 16;13:791-802. Epub 2021 Jun 16.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Alexandra Hospital, Athens, Greece.

Introduction: Circadian rhythm sleep-wake disorder (CRSWD) is an often-misdiagnosed group of sleep disturbances with limited data concerning diagnostic and therapeutic algorithms in the general population. Therefore, reported prevalence varies in the literature due to different case definitions, methodological, and environmental factors.

Objectives: The purpose of our cross-sectional study was to estimate the prevalence of CRSWD in the general population of Cyprus and to suggest clinical parameters for the assessment of atypical sleep schedules. Read More

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Risk of Death in the Elderly with Excessive Daytime Sleepiness, Insomnia and Depression: Prospective Cohort Study in an Urban Population in Northeast Brazil.

Arq Bras Cardiol 2021 Jun 18. Epub 2021 Jun 18.

Universidade Federal do Rio Grande do Norte - Odontologia, Natal, RN - Brasil.

Background: The close relationship between sleep regulation and cardiovascular events is one of the main focuses of research in contemporary medicine. Sleep habits and characteristics interfere with the cardiac rhythm and also with life expectancy, especially in the elderly.

Objective: To estimate the risk of death and cardiovascular events in community-dwelling elderly individuals complaining of insomnia and excessive daytime sleepiness over eight years of follow-up. Read More

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Fatal insomnia: the elusive prion disease.

BMJ Case Rep 2021 Jun 22;14(6). Epub 2021 Jun 22.

College of Medicine and Health, University of Exeter, Exeter, UK.

A previously well 54- year-old woman presented with a short history of diplopia, cognitive decline, hallucinations and hypersomnolence. The patient had progressive deterioration in short-term memory, ocular convergence spasm, tremor, myoclonus, gait apraxia, central fever, dream enactment and seizures. Results of investigations were normal including MRI brain, electroencephalogram, cerebrospinal fluid (CSF, including CSF prion protein markers) and brain biopsy. Read More

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Transdiagnostic efficacy of a group exercise intervention for outpatients with heterogenous psychiatric disorders: a randomized controlled trial.

BMC Psychiatry 2021 06 22;21(1):313. Epub 2021 Jun 22.

Department of Education & Health Research, Faculty of Economics and Social Sciences, Institute of Sports Science, University of Tuebingen, 72074, Tuebingen, Germany.

Background: Exercise efficaciously reduces disorder-specific symptoms of psychiatric disorders. The current study aimed to examine the efficacy of a group exercise intervention on global symptom severity and disorder-specific symptoms among a mixed outpatient sample.

Methods: Groups of inactive outpatients, waiting for psychotherapy, with depressive disorders, anxiety disorders, insomnia, and attention-deficit/hyperactivity disorders were randomized to a manualized 12-week exercise intervention, combining moderate to vigorous aerobic exercise with techniques for sustainable exercise behaviour change (n = 38, female = 71. Read More

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Presence of PTSD is Associated with Clinical and Functional Impact in Veterans with Depression Treated in Community-Based Clinics.

J Clin Psychol Med Settings 2021 Jun 22. Epub 2021 Jun 22.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1977 Butler Blvd., Suite 400, Houston, TX, 77030, USA.

Providers in non-traditional mental health settings (e.g., primary care, community medical clinics) face challenges involving patients who often present with multiple mental health conditions, but require rapid assessment and treatment. Read More

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Relationship between sleep quality and cognitive performance in patients with epilepsy.

Epilepsy Behav 2021 Jun 16;122:108127. Epub 2021 Jun 16.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Epilepsy Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. Electronic address:

Purpose: To investigate the relationship between self-reported sleep quality and cognitive function in patients with epilepsy (PWE), as well as anxiety and depressive symptoms and patient quality of life (QoL).

Methods: This multicenter cross-sectional study included PWE aged ≥12 years who were receiving ≥1 anti-seizure medication (ASM) and had not been diagnosed with a sleep disorder. Patients completed the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), the Montreal Cognitive Assessment test (MoCA), the Hospital Anxiety and Depression Scale (HADS), and the Quality of Life in Epilepsy Inventory-10 (QOLIE-10). Read More

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[Insomnia in the context of neurological diseases].

Moritz D Brandt

Fortschr Neurol Psychiatr 2021 Jun 18;89(6):314-328. Epub 2021 Jun 18.

This article provides an overview of the prevalence, cause and treatment of insomnia in common neurological diseases (restless legs syndrome, stroke, multiple sclerosis, Parkinson´s disease and Alzheimer´s disease) with an additional focus on the bidirectional relationship between sleep and neurological disorders.Insomnia is prevalent, but frequently unrecognized in the context of neurological diseases. Although it is widely known that sleep has a relevant impact on quality of life in general and cerebral function in particular, sleep disorders receive little attention in the prevention and treatment of neurological diseases. Read More

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Acute Stress Response Profiles in Health Workers Facing SARS-CoV-2.

Front Psychol 2021 31;12:660156. Epub 2021 May 31.

Istituto Europeo per lo Studio del Comportamento Umano, ONLUS, Parma, Italy.

Objective: The study is an explorative investigation aimed to assess the differences in acute stress response patterns of health workers facing coronavirus disease 2019 (COVID-19) during Italy's first lockdown.

Methods: A cross-sectional investigation using convenience sampling method was conducted in Italy during April 2020. Eight hundred fifty-eight health workers participated in the research filling out self-report measures including Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder (GAD-7), Insomnia Severity Index (ISI), and Impact of Event Scale-Revised (IES-R). Read More

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Cross-Lagged Relationships Between Insomnia and Posttraumatic Stress Disorder in Treatment-Receiving Veterans.

Behav Ther 2021 07 5;52(4):982-994. Epub 2021 Jan 5.

Phoenix Australia-Centre for Posttraumatic Mental Health and University of Melbourne.

Insomnia is a risk factor for the development of posttraumatic stress disorder (PTSD) while it is also plausible that PTSD symptoms can maintain insomnia symptoms. The present study examined longitudinal bidirectional relationships between insomnia and PTSD symptoms in treatment-seeking veterans. Participants were 693 ex-serving members of the Australian Defence Force who participated in an accredited, hospital-based outpatient PTSD program. Read More

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Eveningness Predicts Negative Affect Following Sleep Restriction.

Behav Ther 2021 07 26;52(4):797-805. Epub 2020 Oct 26.

Vanderbilt University.

Although considerable research has shown that sleep loss results in decreased positive affect, findings regarding change in negative affect are inconsistent. Such inconsistency may be due in part to variability in individual difference factors, such as chronotype, which is associated with both sleep and affective outcomes. Chronotype represents the tendency to be a morning- or evening-type person and is underpinned by the timing of circadian processes linked to sleep and mental health. Read More

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Prevalence of insomnia and anxiety among healthcare workers during the COVID-19 pandemic in Jilin Province.

Braz J Med Biol Res 2021 14;54(9):e10602. Epub 2021 Jun 14.

Department of Geriatrics, Jilin Academy of Chinese Medicine Sciences, Changchun, Jilin, China.

The outbreak of the 2019 novel coronavirus disease (COVID-19) has impacted the mental health of healthcare providers at the frontline. Therefore, we conducted this study to estimate the prevalence rate of anxiety and insomnia and identify associated risk factors among healthcare workers in Jilin, China, during the period from January 25 to February 25, 2020. Zung's Self-Reported Anxiety Scale (SAS) and the Insomnia Severity Index (ISI) scale were used to diagnose anxiety and insomnia, respectively. Read More

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Implementation of a digital cognitive behavioral therapy for insomnia pathway in primary care.

Contemp Clin Trials 2021 Jun 12;107:106484. Epub 2021 Jun 12.

The Adelaide Institute for Sleep Health, A Centre of Research Excellence and Flinders Health and Medical Research Institute, Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; National Centre for Sleep Health Services Research, A NHMRC Centre of Research Excellence, Flinders University, Adelaide, South Australia, Australia.

Background Insomnia is a prevalent and debilitating disorder commonly managed by family physicians. Insomnia guidelines recommend cognitive behavioral therapy for insomnia (CBTi) as the 'first-line' treatment. However, family physicians report limited time, knowledge, access, support, and referral options to manage patients with CBTi. Read More

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Safety and Effectiveness of SEP-363856 in Schizophrenia: Results of a 6-Month, Open-Label Extension Study.

CNS Spectr 2021 Apr;26(2):148-149

Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.

Background: SEP-363856 is a novel psychotropic agent without dopamine D2 receptor occupancy. Although its mechanism of action has not been fully elucidated, preclinical data suggest that agonism at trace amine receptor 1 (TAAR1) and the serotonin 5-H1A receptor contributes to its efficacy. In a double-blind (DB), placebo-controlled study, SEP-363856 demonstrated significant efficacy in the treatment of an exacerbation of schizophrenia (Koblan et al, NEJM 2020; 82:1497-1506). Read More

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A living systematic review of the psychological problems in people suffering from COVID-19.

J Affect Disord 2021 Jun 2;292:172-188. Epub 2021 Jun 2.

Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Institute for Excellence in Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Objectives: We aimed to investigate the psychological problems on people infected with SARS-CoV-2 during the pandemic.

Methods: In this living systematic review and meta-analyses, we searched seven electronic databases for cross-sectional studies and longitudinal studies on psychological problems on COVID-19 patients from Jan 1, 2020 to Oct 7, 2020. The primary outcome was prevalence of various psychological problems such as anxiety, depression, stress, insomnia, somatization, and fear. Read More

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Tools for the evaluation of the psychological impact of COVID-19: A practical guide for Family physicians and Primary Care Practitioners.

J Family Med Prim Care 2021 Apr 29;10(4):1503-1507. Epub 2021 Apr 29.

Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.

The COVID-19 pandemic has affected the global population significantly and has resulted in physiological, psychological, social, and behavioral changes among the individuals. The prominent mental health effects of COVID-19 on the general and clinical populations have been well recognized. The family physicians and primary care practitioners from various disciplines are likely to encounter patients who are experiencing psychological distress manifested in the form of anxiety, depression, stress, insomnia, increased substance use, or other symptoms. Read More

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Comparative efficacy of lemborexant and other insomnia treatments: a network meta-analysis.

J Manag Care Spec Pharm 2021 Jun 12:1-13. Epub 2021 Jun 12.

Eisai Inc., Woodcliff Lake, NJ.

Insomnia is a common disorder associated with a substantial burden of illness, particularly in older adults. To compare the efficacy and safety of lemborexant with specified other insomnia treatments through a systematic literature review and network meta-analysis (NMA). Medline and Embase were systematically searched from inception to February 2019 and updated with a targeted search of PubMed for pivotal trials in March 2021. Read More

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Efficacy of cognitive behavioral therapy for insomnia in geriatric primary care patients.

J Am Geriatr Soc 2021 Jun 13. Epub 2021 Jun 13.

Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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The Impact of Cognitive-Behavioral Interventions on Sleep Disturbance in Depressed and Anxious Community-dwelling Older Adults: A Systematic Review.

Behav Sleep Med 2021 Jun 14:1-23. Epub 2021 Jun 14.

Department of Psychological Services, Sheffield Teaching Hospitals, UK.

: Depression and anxiety are prevalent mental health conditions in older adulthood. Despite sleep disturbance being a common comorbidity in late-life depression and anxiety, it is often discounted as a target for treatment. The current review aims to establish whether cognitive-behavioral therapy (CBT) is effective in treating concomitant sleep disturbance in depressed and anxious older adults and to review evidence supporting whether CBT interventions targeting anxiety and depression, or concurrent sleep disturbance, have the greatest effectiveness in this client group. Read More

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Treating Insomnia Symptoms with Medicinal Cannabis: A Randomized, Cross-Over Trial of the Efficacy of a Cannabinoid Medicine Compared with Placebo.

Sleep 2021 Jun 11. Epub 2021 Jun 11.

Centre for Sleep Science, School of Human Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia.

Study Objectives: This randomized, double-blind, placebo-controlled, cross-over study was conducted to evaluate the safety and efficacy of two-weeks of nightly sublingual cannabinoid extract (ZTL-101) in treating chronic insomnia (symptoms ≥three months).

Methods: Co-primary study endpoints were safety of the medication based on adverse event reporting and global insomnia symptoms (Insomnia Severity Index; ISI). Secondary endpoints included: self-reported (sleep diary), actigraphy-derived and polysomnography measurements of sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), sleep efficiency (SE); and self-reported assessments of sleep quality (sSQ) and feeling rested upon waking. Read More

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Effect of exercise intervention on primary insomnia: a meta-analysis.

J Sports Med Phys Fitness 2021 Jun;61(6):857-866

Institute of Sport Science, Sichuan University, Chengdu, China -

Introduction: Exercise can have a positive effect on body functioning and immunity. This study systematically evaluated the effect of exercise intervention on patients diagnosed with primary insomnia. Based on the meta-analysis, we developed exercise recommendations to help improving sleep quality in these patients. Read More

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[Dream content in different sleep disorders: sleep apnoea and hypopnoea syndrome, primary insomnia, idiopathic REM sleep behaviour disorder and narcolepsy type 1].

Rev Neurol 2021 Jun;72(12):411-418

Hospital Clinic de Barcelona, Barcelona, España.

Aim: The aim of this study is to determine whether there are any differences in the dream content in different sleep disorders and to describe their characteristics.

Patients And Methods: We studied four sleep disorders: sleep apnoea and hypopnoea syndrome (SAHS), primary insomnia (PI), idiopathic REM sleep behaviour disorder (IRBD) and narcolepsy type I. Each patient was asked to keep a dream diary for two weeks. Read More

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Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain-intestine interaction in the treatment of insomnia.

Medicine (Baltimore) 2021 May;100(19):e25854

Nursing College of Changchun University of Chinese Medicine, Changchun, China.

Background: Insomnia is a common disease associated with different nervous system stress response and endocrine disorders. It has been reported previously that abdominal vibration and ring massage therapy can significantly improve the symptoms of insomnia patients, enhance the activity of neurons. In addition, functional MRI (resting state brain functional magnetic resonance imaging [Rs_fMRI]) of the resting state brain test has proved that the functional connection between hypothalamus and parahippocampal gyrus could be significantly enhanced after abdominal massage treatment. Read More

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Prevalence of insomnia in shift workers: a systematic review.

Sleep Sci 2021 Jan-Mar;14(1):47-54

Escola Bahiana de Medicina e Saúde Pública, Medicina - Salvador - Bahia - Brazil.

Insomnia is a sleep disorder of high prevalence with somatic and psychic repercussions. The present study aimed to describe the prevalence of insomnia in shift workers, as well as the associated variables: gender, age, marital status, profession and shift work schedule. A systematic review was performed using the descriptors "insomnia" AND "shift work", in the PubMed, SciELO and LILACS databases, including studies that presented frequency of insomnia in shift workers, published between 2000 and 2020, in English or Portuguese, only in individuals over 18-years-old. Read More

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Protocol for the Project SAVE randomised controlled trial examining CBT for insomnia among veterans in treatment for alcohol use disorder.

BMJ Open 2021 06 8;11(6):e045667. Epub 2021 Jun 8.

Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA.

Introduction: As many as 74% of veterans with alcohol use disorders (AUDS) report symptoms of insomnia. Insomnia represents a barrier to alcohol treatment because insomnia symptoms (1) may lead to relapse among those who use alcohol to help them sleep and may negatively impact (2) executive functions and (3) emotion regulation skills. Cognitive-behavioural therapy for insomnia (CBT-I) is an efficacious first-line treatment for insomnia; however, no research has examined the impact of CBT-I on individuals' response to alcohol treatment. Read More

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Associations between sleep disturbances, diabetes and mortality in the UK Biobank cohort: A prospective population-based study.

J Sleep Res 2021 Jun 8:e13392. Epub 2021 Jun 8.

Department of Neurology, Center for Circadian and Sleep Medicine, Northwestern University, Chicago, IL, USA.

Non-communicable diseases, including diabetes, are partly responsible for the deceleration of improvements of life expectancy in many countries. Diabetes is also associated with sleep disturbances. Our aim was to determine whether sleep disturbances, particularly in people with diabetes, were associated with increased mortality risk. Read More

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Effect of the COVID-19 on perceptions of health, anticipated need for health services, and cost of healthcare.

Disaster Med Public Health Prep 2021 Jun 8:1-28. Epub 2021 Jun 8.

Associate Professor, Public Policy and Administration Unit, College of Arts and Sciences, Governors State University, 1 University Parkway, University Park, IL 60484.

Objective: This article investigates how perceived vulnerability to the COVID-19 pandemic at its early stages is associated with people's perception of their health, the need for healthcare services, and expenses related to addressing the COVID-19 impact on their health.

Methods: The results are based on the analysis of surveys that were distributed among members of 26 random Facebook groups in April-May, 2020. Perceived COVID-19 pandemic related stress and health concerns were examined by using the ANOVA test. Read More

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The cerebral mechanism of acupuncture for chronic insomnia with gastrointestinal disorder: protocol for a randomized controlled trial.

Trials 2021 Jun 7;22(1):386. Epub 2021 Jun 7.

Acupuncture & Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.

Background: Many patients with chronic insomnia disorder (CID) have gastrointestinal (GI) symptoms. First-line insomnia medications do not treat GI problems. Acupuncture has a comprehensive regulative action on both CID and GI disorder and is receiving increasing attention. Read More

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Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation.

J Ethnopharmacol 2021 Jun 3:114296. Epub 2021 Jun 3.

Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, 226031; Tanslational Health Science and Technology, Faridabad, 121001, India. Electronic address:

Ethno-pharmacological Relevance: Withania somnifera (L.) Dunal, commonly known as Ashwagandha, belongs to the family Solanaceae. In Ayurveda, Ashwagandha has been defined as one of the most important herb and is considered to be the best adaptogen. Read More

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[Covid-19 and front-line nurses' mental health: a literature review].

Prof Inferm 2021 Jan-Mar;74(1):41-47

Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi D'Aragona Cava de Tirreni, Salerno, Italia.

Introduction: The Coronavirus (Covid-19) pandemic caused a severe health crisis that has affected millions of people and quarantined half of the world's population. The health emergency from Covid-19 has seen health workers on the front line face all the difficulties related to the burden of care and the reorganization of procedures, roles, and tools at the hospital level. One of the most significant and probably underestimated aspects is the psychological stress of frontline nurses. Read More

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