18,345 results match your criteria Primary Insomnia


Cognitive behavioural therapy for insomnia (CBTi) as a treatment for tinnitus-related insomnia: a randomised controlled trial.

Cogn Behav Ther 2022 Jun 28:1-19. Epub 2022 Jun 28.

Department of Psychology, University College London Hospitals NHS Foundation Trust, London, UK.

Insomnia is a significant difficulty and is reported by large proportion of tinnitus. Although cognitive behavioural therapy for insomnia (CBTi) might be an effective treatment, no controlled studies had been conducted to date. This randomised controlled trial evaluated the benefits of CBTi on a sample of 102 people with tinnitus-related insomnia. Read More

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Comparative efficacy and acceptability of cognitive behavioral therapy delivery formats for insomnia in adults: A systematic review and network meta-analysis.

Sleep Med Rev 2022 May 31;64:101648. Epub 2022 May 31.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China. Electronic address:

This review compared the efficacy and acceptability of different delivery formats for cognitive behavioral therapy for insomnia (CBT-I) in insomnia. We searched five databases for randomized clinical trials that compared one CBT-I delivery format against another format or control conditions for insomnia in adults. We used pairwise meta-analyses and frequentist network meta-analyses with the random-effects model to synthesize data. Read More

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Getting on the Same Page: A Quality Improvement Project to Enhance Nurse-to-Resident Communications and Reduce Overnight Sleep Interruptions.

J Grad Med Educ 2022 Jun 13;14(3):311-317. Epub 2022 Jun 13.

is PM&R Assistant Professor, Virginia Commonwealth University Health System.

Background: Many residency programs utilize "home call" residents who answer hospital communications and place orders from home. Often, residents are required to live nearby and arrive in-person if needed. Residents work normal daytime work hours while on home call, which can last several nights. Read More

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Abuse Potential of Lemborexant, a Dual Orexin Receptor Antagonist, Compared With Zolpidem and Suvorexant in Recreational Sedative Users.

J Clin Psychopharmacol 2022 Jul-Aug 01;42(4):365-373. Epub 2022 Jun 24.

Eisai Inc, Nutley, NJ.

Background: Lemborexant (LEM) is a dual orexin receptor antagonist approved for the treatment of insomnia in adults in multiple countries including the the United States, Japan, Canada, Australia and several Asian countries.

Procedures: This was a randomized, single-dose, single-center, double-blind, active-control, 6-way crossover study to evaluate LEM abuse potential. The study assessed oral doses of LEM 10 mg (LEM10), 20 mg (LEM20), and 30 mg (LEM30) compared with placebo (PBO), zolpidem (ZOL) immediate release 30 mg, and suvorexant (SUV) 40 mg. Read More

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Associated Psychological Factors of Viral Load among Self-Isolating Nigerian COVID-19 Patients.

West Afr J Med 2022 Jun;39(6):588-594

Department of Public Health, Osun State Ministry of Health, Osogbo, Osun State, Nigeria.

Background: Corona virus disease 2019 (COVID-19) is a pandemic that has affected millions of people worldwide. The aim of this study was to explore the psychological factors of viral load among COVID-19 patients who were on self-isolation in Nigeria.

Methods: This is a cross-sectional study involving five hundred and nine self-isolating COVID-19 patients in Osogbo, Nigeria. Read More

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Aprepitant plus palonosetron versus dexamethasone plus palonosetron in preventing chemotherapy-induced nausea and vomiting in patients with moderate-emetogenic chemotherapy: A randomized, open-label, phase 3 trial.

EClinicalMedicine 2022 Jul 3;49:101480. Epub 2022 Jun 3.

Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University No. 26, Yuancunerheng Road, Guangzhou 510655, China.

Background: Despite significant progress in the prevention of chemotherapy-induced nausea and vomiting (CINV) by using dexamethasone combined with palonosetron for patients who received moderate-emetogenic chemotherapy (MEC), some of these patients still suffer from CINV. We evaluated whether aprepitant combined with palonosetron can improve the efficacy in the prevention of CINV in patients receiving MEC.

Methods: This was a single-centre, open-label, phase III, randomized controlled trial, which was done at the Sixth Affiliated Hospital of Sun Yat-sen University of China. Read More

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The Usefulness of the Athens Insomnia Scale for Evaluating Sleep Disturbance in Patients with Chronic Liver Disease Comparing with Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale.

Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Kanto Central Hospital, Tokyo 158-8531, Japan.

: Sleep disturbance due to muscle cramps or hepatic encephalopathy in patients with chronic liver disease (CLD) can lead to a reduced quality of life. The Pittsburgh sleep quality index (PSQI) is commonly used for evaluating sleep disturbance; however, this questionnaire is time-consuming owing to the large number of questions. As the usefulness of the Athens insomnia scale (AIS) in patients with CLD is not sufficiently known, the present study aimed to determine whether the AIS and Epworth sleepiness scale (ESS) could be used as simple alternative questionnaires for evaluating sleep disturbances in patients with CLD. Read More

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Fibromyalgia Syndrome and Cognitive Decline: The Role of Body Mass Index and Clinical Symptoms.

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Psychology, University of Jaén, 23071 Jaén, Spain.

The high prevalence of obesity and overweight in fibromyalgia (FM) may be an important factor in the well-known cognitive deficits seen in the disorder. This study analyzed the influence of body mass index (BMI) and primary clinical symptoms of FM (pain, fatigue, insomnia, anxiety, and depression) on attention, memory, and processing speed in FM. Fifty-two FM patients and thirty-two healthy participants completed cognitive tasks assessing selective, sustained, and divided attention; visuospatial and verbal memory; and information processing speed. Read More

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Adherence to a Healthy Sleep Pattern and Incidence of Cardiometabolic Multimorbidity Among Hypertensive Patients: A Prospective Study of UK Biobank.

Sleep 2022 Jun 23. Epub 2022 Jun 23.

Department of Geriatric Medicine, Center of Coronary Circulation, Xiangya Hospital, Central South University, Changsha, China.

Study Objectives: To investigate whether a healthy sleep pattern would reduce the risk of cardiometabolic multimorbidity (CMM) among hypertensives.

Methods: This is a prospective cohort analysis from the UK Biobank. A total of 69,524 hypertensives without a history of diabetes mellitus, coronary heart disease, or stroke at baseline were enrolled. Read More

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Thalamic-insomnia phenotype in E200K Creutzfeldt-Jakob disease: A PET/MRI study.

Neuroimage Clin 2022 Jun 18;35:103086. Epub 2022 Jun 18.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Insomnia and thalamic involvement were frequently reported in patients with genetic Creutzfeldt-Jakob disease (gCJD) with E200K mutations, suggesting E200K might have discrepancy with typical sporadic CJD (sCJD). The study aimed to explore the clinical and neuroimage characteristics of genetic E200K CJD patients by comprehensive neuroimage analysis.

Methods: Six patients with gCJD carried E200K mutation on Prion Protein (PRNP) gene, 13 patients with sporadic CJD, and 22 age- and sex-matched normal controls were enrolled in the study. Read More

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Preventive pharmacological treatment in subjects at risk for fatal familial insomnia: science and public engagement.

Prion 2022 Dec;16(1):66-77

Fondazione Telethon ETS, Milano, Italy.

Engaging patients as partners in biomedical research has gradually gained consensus over the last two decades. They provide a different perspective on health priorities and help to improve design and outcomes of clinical studies. This paper describes the relationship established between scientists and members of a large family at genetic risk of very rare lethal disease, fatal familial insomnia (FFI). Read More

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December 2022

Mild-to-Moderate Traumatic Brain Injury: A Review with Focus on the Visual System.

Neurol Int 2022 May 30;14(2):453-470. Epub 2022 May 30.

Department of Medicine, Biomedical Research Institute, NYU Long Island School of Medicine, Mineola, NY 11501, USA.

Traumatic Brain Injury (TBI) is a major global public health problem. Neurological damage from TBI may be mild, moderate, or severe and occurs both immediately at the time of impact (primary injury) and continues to evolve afterwards (secondary injury). In mild (m)TBI, common symptoms are headaches, dizziness and fatigue. Read More

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A cross-sectional study on sleep length, quality, and mobile phone use among Moroccan adolescents.

Pan Afr Med J 2022 28;41:252. Epub 2022 Mar 28.

Biochemistry, Neurosciences, Natural Resources and Environment Laboratory, Faculty of Sciences and Technology, Hassan First University, Settat, Morocco.

Introduction: sleep plays an important role in learning and the formation of memories among adolescents, and lack of sleep affects their health, safety, and school performance, especially in the age of mobile phones. This study´s aim was to investigate sleep length and sleep quality among Moroccan adolescents and assess their relationship to mobile phone use.

Methods: the population of this cross-sectional study included all the adolescent students aged 12-20 years, living in the Settat region, Morocco. Read More

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Insomnia in patients with acute heart failure: from the KCHF registry.

ESC Heart Fail 2022 Jun 22. Epub 2022 Jun 22.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Aims: Insomnia is a known risk factor for heart failure (HF) and a predictor of cardiac events in HF patients, but the clinical significance of insomnia in patients with acute HF (AHF) is not adequately evaluated. This study aimed to investigate the association between insomnia and subsequent clinical outcomes in patients with AHF.

Methods: From the Kyoto Congestive Heart Failure registry, consecutive 3414 patients hospitalized for HF who were discharged alive were divided into the 2 groups at discharge: insomnia group and non-insomnia group. Read More

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IL-4/13 Blockade and sleep-related adverse drug reactions in over 37,000 Dupilumab reports from the World Health Organization Individual Case Safety reporting pharmacovigilance database (VigiBase™): a big data and machine learning analysis.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):4074-4081

Department of Computer Science, College of Computers and Information Technology, Taif University, Taif, Saudi Arabia.

Objective: Atopic dermatitis displays a relevant sleep burden sustained by clinical (i.e., itch), psychological (i. Read More

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Relationship between attention deficit hyperactivity disorder and temporomandibular disorders in adults: a questionnaire-based report.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3858-3871

Faculty of Food Science and Nutrition, University and Health Sciences, Poznan, Poland.

Objective: The symptoms of the attention deficit hyperactivity disorder (ADHD) persist in the adult years of life in most cases. They appear in adults with accompanying psychosocial problems. Temporomandibular disorder (TMD) refers to signs and symptoms associated with pain of non-dental origin in the oro-facial region, functional and structural disruptions of the masticatory system, especially the temporomandibular joints (TMJs) and masticatory muscles. Read More

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Testing delivery of components of cognitive behavioral therapy for insomnia to breast cancer survivors by smart speaker: a study protocol.

BMC Med Inform Decis Mak 2022 Jun 21;22(1):163. Epub 2022 Jun 21.

Healthcare Delivery Research, MedStar Health Research Institute, Washington, DC, USA.

Background: Insomnia is common in breast cancer survivors (BCS), affecting an estimated 30-50% of the 3.8 million BCS in the US. Insomnia is associated with health consequences for cardiometabolic and immune systems, neurobehavioral function, depression, fatigue, and quality of life and may put BCS at particular risk. Read More

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Prevalence and factors associated with insomnia symptoms in adolescents and young adults with cancer during the COVID-19 pandemic.

Sleep Health 2022 Jun 18. Epub 2022 Jun 18.

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada; Section of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, Canada.

Objective: The COVID-19 pandemic has been particularly distressing for adolescents and young adults (AYAs) diagnosed with cancer. High levels of distress are associated with sleep disturbances. This study examined the prevalence of insomnia symptoms in AYAs during the COVID-19 pandemic and identified factors related to greater insomnia severity. Read More

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A systematic review of sleep problems in children and adolescents with obsessive compulsive disorder.

J Anxiety Disord 2022 Jun 8;90:102591. Epub 2022 Jun 8.

Toronto Metropolitan University, Department of Psychology, 350 Victoria St, Toronto, ON M5B 2K3, Canada. Electronic address:

There is growing interest in the relationship between obsessive-compulsive disorder (OCD) and sleep problems in youth, including the development of a theoretical model proposing how these disorders maintain each other. The model suggests that OCD symptoms are proposed to interfere with sleep duration (e.g. Read More

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Assessment of Smartphone Apps for Common Neurologic Conditions (Headache, Insomnia, and Pain): Cross-sectional Study.

JMIR Mhealth Uhealth 2022 Jun 21;10(6):e36761. Epub 2022 Jun 21.

Department of Psychiatry, Beth Israel Deaconess Medical Center, New York, NY, United States.

Background: There are thousands of apps for individuals struggling with headache, insomnia, and pain, but it is difficult to establish which of these apps are best suited for patients' specific needs. If clinicians were to have access to a platform that would allow them to make an informed decision on the efficacy and feasibility of smartphone apps for patient care, they would feel confident in prescribing specific apps.

Objective: We sought to evaluate the quality of apps for some of the top common, disabling neurologic conditions (headache, insomnia, and pain) based on principles derived from the American Psychiatric Association's (APA) app evaluation model. Read More

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Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

JAMA Netw Open 2022 Jun 1;5(6):e2217709. Epub 2022 Jun 1.

Ambulatorio di Diabetologia, Unità Operativa Complessa (UOC) Medicina Interna E D'Urgenza, Policlinico Universitario, Azienda Ospedaliero Universitaria (AOU) Policlinico-G. Rodolico-San Marco, Catania, Italy.

Importance: Evidence of effective smoking cessation interventions in patients with diabetes is limited. The unique behavioral and metabolic characteristics of smokers with type 2 diabetes warrants a randomized clinical trial of the smoking cessation drug varenicline.

Objective: To evaluate the efficacy and safety of varenicline in patients with type 2 diabetes with an intention to quit smoking. Read More

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Orally Administered Plasmalogens Alleviate Negative Mood States and Enhance Mental Concentration: A Randomized, Double-Blind, Placebo-Controlled Trial.

Front Cell Dev Biol 2022 2;10:894734. Epub 2022 Jun 2.

Institute of Rheological Functions of Food, Fukuoka, Japan.

Plasmalogens have been shown to improve neurodegenerative pathology and cognitive function. We hypothesized that plasmalogens work in small amounts as a kind of hormone interacting with a G protein-coupled receptor, and then explored the effects of scallop-derived purified plasmalogens on psychobehavioral conditions in a randomized placebo-controlled trial of college athletes in Japan. Eligible participants were male students aged 18-22 years who belonged to university athletic clubs. Read More

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Different Impacts of COVID-19 on Quality of Therapy, Psychological Condition, and Work Life Among Occupational Therapists in Physical and Mental Health Fields.

Front Public Health 2022 3;10:887069. Epub 2022 Jun 3.

Department of Occupational Therapy, Saitama Prefectural University, Koshigaya, Japan.

Background: The negative impacts of the coronavirus disease 2019 (COVID-19) pandemic have worsened the quality of therapy, psychological condition, and work life of second-line healthcare workers and occupational therapists (OTs). However, no study has investigated whether the impact of COVID-19 varies among OTs working in different fields. This study aimed to investigate the differences on the impact of COVID-19 between OTs in the physical and mental health fields. Read More

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[Effect of transcutaneous auricular vagus nerve stimulation on nocturnal autonomic nervous function in primary insomnia patients].

Zhongguo Zhen Jiu 2022 Jun;42(6):619-22

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Objective: To observe the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on the sleep quality and nocturnal heart rate variability (HRV) in patients with primary insomnia.

Methods: Twenty-one patients with primary insomnia were included. Using SDZ-ⅡB electric acupuncture apparatus, Xin (CO) and Shen (CO) were stimulated with disperse-dense wave, 4 Hz/ 20 Hz in frequency, (0. Read More

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[Acupuncture for perimenopausal early-wake insomnia: a randomized controlled trial].

Zhongguo Zhen Jiu 2022 Jun;42(6):608-12

Department of Acupuncture and Moxibustion, Zhejiang Hospital, Hangzhou 310013, China.

Objective: To observe the clinical effect of acupuncture for perimenopausal early-wake insomnia.

Methods: A total of 60 patients with perimenopausal early-wake insomnia were randomly divided into an observation group (30 cases, 3 cases dropped off) and a control group (30 cases, 2 cases dropped off, 2 cases were removed). In the observation group, acupuncture was applied at Baihui (GV 20), Yintang (GV 24), Anmian (Extra), Hegu (LI 4), Shenmen (HT 7), Taichong (LR 3), Taixi (KI 3), etc. Read More

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Intranasal Dexmedetomidine for the Treatment of Pre-operative Anxiety and Insomnia: A Prospective, Randomized, Controlled, and Clinical Trial.

Front Psychiatry 2022 30;13:816893. Epub 2022 May 30.

Department of Anaesthesiology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Background And Objective: Several patients with pre-operative anxiety and insomnia refuse to take sleeping pills because of the side effects of sleeping pills. This study aimed to evaluate the applicability of intranasal dexmedetomidine (DEX) in the treatment of pre-operative anxiety and insomnia.

Methods: A total of 72 patients with insomnia and anxiety were randomly divided into two groups of intranasal DEX (n = 36) and intranasal normal saline (NS, n = 36). Read More

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The Effect of Lavender on Sleep Quality in Individuals Without Insomnia: A Systematic Review.

Holist Nurs Pract 2022 Jul-Aug 01;36(4):223-231

Graduate School of Nursing, Sapporo City University, Sapporo, Japan.

We reviewed 20 randomized controlled trials concerning the intervention methods and effects of lavender essential oil on adults' sleep quality. Fourteen showed positive intervention effects. A mixture of subjective and objective indicators was used. Read More

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Hyperhidrosis in sleep disorders - A narrative review of mechanisms and clinical significance.

J Sleep Res 2022 Jun 15:e13660. Epub 2022 Jun 15.

Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Hyperhidrosis is characterized by excessive sweating beyond thermoregulatory needs that affects patients' quality of life. It results from an excessive stimulation of eccrine sweat glands in the skin by the sympathetic nervous system. Hyperhidrosis may be primary or secondary to an underlying cause. Read More

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Hiccups in patients with cancer: a multi-site, single-institution study of etiology, severity, complications, interventions, and outcomes.

BMC Cancer 2022 Jun 15;22(1):659. Epub 2022 Jun 15.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To our knowledge, previous studies have not investigated hiccups in patients with cancer with detailed patient-level data with the goal of capturing a broad spectrum of hiccup symptomatology.

Methods: This multi-site, single institution study examined consecutive medical records to better understand hiccups in patients with cancer.

Results: A total of 320 patients are the focus of this report. Read More

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Case-based, asynchronous sleep education outcomes among primary care nurse practitioner students.

J Clin Sleep Med 2022 Jun 15. Epub 2022 Jun 15.

University of Pennsylvania Perelman School of Medicine, Division of Sleep Medicine, Philadelphia, Pennsylvania.

Study Objectives: Primary care nurse practitioners (NPs) receive little sleep education in graduate programs but are often first-line providers for patients presenting with sleep-related symptoms. A pre/post evaluation study was conducted using asynchronous, case-based sleep education modules in a cohort of primary care NP students enrolled in a single academic institution's nursing master's degree program.

Methods: Six virtual, case-based modules addressed adult sleep health and disorders, prioritized based on prevalence and primary care presentation. Read More

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