1,517,468 results match your criteria Primary Care Optometry News [Journal]


The Association Between Telemedicine and Emergency Department (ED) Disposition: A Stepped Wedge Design of an ED-Based Telemedicine Program in Critical Access Hospitals.

J Rural Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Management and Policy, University of Iowa College of Public Health, Iowa City, Iowa.

Purpose: To study the relationship between the availability and activation of emergency department-based telemedicine (teleED) and patient disposition in Critical Access Hospitals (CAHs).

Methods: A non randomized stepped wedge design examined 133,396 ED visits in 15 CAHs that subscribe to a single teleED provider. Data were available for at least 12 months prior to teleED implementation and at least 12 months of post-implementation. Read More

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http://dx.doi.org/10.1111/jrh.12370DOI Listing

[Nasal discharge in dogs - are microbiological and histopathological examinations clinically useful?]

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):84-96. Epub 2019 Apr 23.

Klinik für Kleintiere, HNO-Abteilung, Universitätstierklinikum Leipzig.

Objective: Retrospective evaluation of the diagnostic value of bacterial culture of nasal mucosal swabs and histopathologic assessment of nasal mucosal biopsies in dogs with nasal discharge.

Material And Methods: Medical records of dogs with the predominant clinical sign of nasal discharge that were referred to the ENT Unit of the Small Animal Department between January 2015 and December 2016 were reviewed.

Results: Data of 85 dogs were evaluated. Read More

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http://dx.doi.org/10.1055/a-0863-6667DOI Listing

Long-Term Outcome of Patients Operated with Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment.

Ophthalmic Res 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Purpose: To determine the long-term outcome of patients operated with pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) and to identify potential predictors for poor visual outcome.

Methods: Prospective, observational 30-month study of patients operated for primary RRD with PPV. Examinations were performed preoperatively and after months 2, 6, and 30. Read More

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http://dx.doi.org/10.1159/000499130DOI Listing

Effects of Acupuncture Treatment on Lower Limb Spasticity in Patients Following Hemorrhagic Stroke: A Pilot Study.

Eur Neurol 2019 Apr 23;81(1-2):5-12. Epub 2019 Apr 23.

Department of Traditional Chinese Medicine, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background And Purpose: Lower limb spasticity is often a significant problem in stoke rehabilitation. The purpose of this study was to investigate the effects of acupuncture treatment on lower limb spasticity in patients following hemorrhagic stroke.

Methods: Fifty-nine patients following hemorrhagic stroke were randomized to receive acupuncture treatment combined with conventional treatment (treatment group [TG]) or conventional treatment only (control group [CG]). Read More

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http://dx.doi.org/10.1159/000499133DOI Listing

The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

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http://dx.doi.org/10.1159/000498889DOI Listing

Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Chen, Department of Physiology, Medical College of Nanchang University, Nanchang, China.

Tri-ortho -cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame-retardants in industry and reported to have male reproductive toxicology. However, it is still unknown whether TOCP affects the female reproductive system and its underlying mechanism. In the present study, we found that TOCP exposure significantly decreased ovarian coefficient, caused disintegration and depletion of the granulosa cells in the ovary tissue and significantly inhibited the level of serum estradiol (E2). Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0456DOI Listing
April 2019
1 Read

Myelopathy after zoster virus infection in immunocompetent patients: A case series.

J Spinal Cord Med 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Habib Bourguiba University Hospital , Sfax , Tunisia.

Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607053DOI Listing

Effectiveness of Telephone-Administered Cognitive-Behavioral Psychotherapy for Depression With Versus Without Additional Letters: A Randomized Controlled Trial.

Telemed J E Health 2019 Apr 23. Epub 2019 Apr 23.

3 Clinical Psychology and Psychotherapy Research, Institute of Psychology, University of Zurich, Zurich, Switzerland.

p d. Read More

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http://dx.doi.org/10.1089/tmj.2018.0311DOI Listing

Acupuncture for Primary Insomnia: An Updated Systematic Review of Randomized Controlled Trials.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

1 Beijing University of Chinese Medicine, Beijing, China.

Acupuncture as one of the alternative therapies for insomnia is widely used in Asia and increasingly employed in western countries. To provide updated evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture for primary insomnia. A comprehensive literature search in 11 databases was conducted from January 2008 to October 2017. Read More

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http://dx.doi.org/10.1089/acm.2018.0046DOI Listing

Kinetics of In Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-Diol 4-Methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-linking by the Prodrug Treosulfan.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. Treosulfan converts nonenzymatically to the monoepoxide intermediate (EBDM), and then to (2 S,3 S)-1,2:3,4-diepoxybutane (DEB). The latter alkylates DNA forming mainly (2' S,3' S)- N-7-(2',3',4'-trihydroxybut-1'-yl)guanine (THBG) and (2 S,3 S)-1,4-bis-(guan-7'-yl)-2,3-butane-2,3-diol cross-link (bis-N7G-BD) via the intermediate epoxide adduct (EHBG). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00251DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing

Nurse Practitioner Primary Care Organizational Climate Questionnaire: Item Response Theory and Differential Item Functioning.

J Clin Nurs 2019 Apr 23. Epub 2019 Apr 23.

University of Colorado-Denver, Denver, CO.

Aims And Objectives: To validate Nurse Practitioner Primary Care Organizational Climate Questionnaire (NP-PCOCQ) items using Item Response Theory (IRT) models and conduct Differential Item Functioning (DIF) analysis to test the item functioning among nurse practitioners (NPs) practicing in different U.S. states with variable regulations governing NP practice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14895
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http://dx.doi.org/10.1111/jocn.14895DOI Listing
April 2019
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Airway management of Congenital Pulmonary Airway Malformation Resection in neonates and infants: A case cohort study.

Paediatr Anaesth 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, USA.

Background: Anesthetic management of congenital pulmonary airway malformation has not been well described in the literature whether one lung ventilation is indicated during thoracoscopic lobectomy and if so, what is the best technique to achieve one lung ventilation.

Aim: We describe the variables with the two commonly performed surgical techniques thoracoscopic lobectomy and open thoracotomy from our institutional database to assess the role of lung isolation and the preferable method of lung isolation technique for congenital pulmonary airway malformation resections.

Methods: After institutional review board approval, fetal-center records were reviewed retrospectively from January 2010 to July 2016 for patients who underwent congenital pulmonary airway malformation resection. Read More

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http://dx.doi.org/10.1111/pan.13648DOI Listing

The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation.

Liver Transpl 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.

The evolution of nurse practitioners (NP) and physician assistants (PA) in the United States continues to progress. NPs and PAs have expanded from primary care practices, to medical and surgical specialties, provide acute care in hospitals and intensive care units, and serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice. Read More

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http://dx.doi.org/10.1002/lt.25474DOI Listing

Novel MRI assessment of treatment response in HIV-associated NAFLD: a randomized trial of an SCD1 inhibitor (ARRIVE Trial).

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

NAFLD Research Center, Department of Medicine, La Jolla, California.

Aramchol, an oral stearoyl-coenzyme-A-desaturase-1 (SCD1) inhibitor, has been shown to reduce hepatic-fat content in patients with primary nonalcoholic-fatty-liver-disease (NAFLD), however, its effect in patients with HIV-associated NAFLD is unknown. The ARRIVE trial was a double-blind, randomized, investigator-initiated, placebo-controlled trial to test the efficacy of 12 weeks of treatment with aramchol versus placebo in HIV-associated NAFLD. Fifty patients with HIV-associated NAFLD, defined by MRI-proton-density-fat-fraction (PDFF) ≥5%, were randomized to receive either aramchol 600 mg daily (n=25) or placebo (n=25) for 12 weeks. Read More

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http://dx.doi.org/10.1002/hep.30674DOI Listing

The gut-liver axis in PSC: Are pathobionts the missing link?

Hepatology 2019 Apr 23. Epub 2019 Apr 23.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

Primary sclerosing cholangitis (PSC) is characterized by progressive fibrosis around intra- and extrahepatic bile ducts that can progress to cirrhosis and liver failure. There are no regulatory drugs approved for PSC and liver transplantation is the only effective therapy(1). While the concentric accumulation of periductular fibrosis suggests the biliary epithelial cell (cholangiocyte) plays an integral role in disease initiation and/or progression, multiple factors from the gut like microbes and their molecular products, endogenous metabolites like bile acids, and primed immune cells have been hypothesized to play a significant role in the hepatobiliary injury and adverse clinical sequelae in PSC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30673
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http://dx.doi.org/10.1002/hep.30673DOI Listing
April 2019
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Types of materials for frontalis sling surgery for congenital ptosis.

Cochrane Database Syst Rev 2019 Apr 23;4:CD012725. Epub 2019 Apr 23.

Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, 3332 Rochambeau Avenue, 3rd Floor, Bronx, NY, USA, 10467.

Background: Congenital ptosis is a drooping of one or both eyelids at birth, often due to poor development of the levator palpebrae superioris muscle. This can result in amblyopia, astigmatism, and ocular torticollis and therefore may necessitate surgical intervention in early childhood if visual development is compromised. Patients may have varied levels of levator function. Read More

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http://dx.doi.org/10.1002/14651858.CD012725.pub2DOI Listing

Strategies to improve adherence and continuation of shorter-term hormonal methods of contraception.

Cochrane Database Syst Rev 2019 Apr 23;4:CD004317. Epub 2019 Apr 23.

Research Utilization, FHI 360, 359 Blackwell St, Suite 200, Durham, North Carolina, USA, 27701.

Background: Worldwide, hormonal contraceptives are among the most popular reversible contraceptives. Despite high perfect-use effectiveness rates, typical-use effectiveness rates for shorter-term methods such as oral and injectable contraceptives are much lower. In large part, this disparity reflects difficulties in ongoing adherence to the contraceptive regimen and low continuation rates. Read More

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http://dx.doi.org/10.1002/14651858.CD004317.pub5DOI Listing

Coding Family Medicine Residency Clinic Visits, 99213 or 99214? A Residency Research Network of Texas Study.

Fam Med 2019 Apr 23. Epub 2019 Apr 23.

University of Texas Health Science Center at San Antonio, Department of Family and Community Medicine.

Background And Objectives: The purpose of this study was to characterize Current Procedural Terminology (CPT) coding patterns for professional services in family physician (FP) residency clinics.

Methods: Trained assistants directly observed during every other FP-patient encounter in 10 clinics affiliated with eight residencies of the Residency Research Network of Texas. Three investigators later independently coded each visit for the highest code level reasonably allowed. Read More

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http://dx.doi.org/10.22454/FamMed.2019.862757DOI Listing

Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α.

PLoS One 2019 23;14(4):e0215694. Epub 2019 Apr 23.

Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, United States of America.

There is a vast gulf between the two primary strategies for simulating protein-ligand interactions. Docking methods significantly limit or eliminate protein flexibility to gain great speed at the price of uncontrolled inaccuracy, whereas fully flexible atomistic molecular dynamics simulations are expensive and often suffer from limited sampling. We have developed a flexible docking approach geared especially for highly flexible or poorly resolved targets based on mixed-resolution Monte Carlo (MRMC), which is intended to offer a balance among speed, protein flexibility, and sampling power. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215694PLOS
April 2019
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Can nano-hydroxyapatite permeate the oral mucosa? A histological study using three-dimensional tissue models.

PLoS One 2019 23;14(4):e0215681. Epub 2019 Apr 23.

Sangi Co., Ltd, Central Research Laboratory, Kasukabe, Saitama, Japan.

Nano-hydroxyapatite is used in oral care products worldwide. But there is little evidence yet whether nano-hydroxyapatite can enter systemic tissues via the oral epithelium. We investigated histologically the ability of two types of nano-hydroxyapatite, SKM-1 and Mi-HAP, to permeate oral epithelium both with and without a stratum corneum, using two types of three-dimensional reconstituted human oral epithelium, SkinEthic HGE and SkinEthic HOE respectively with and without a stratum corneum. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215681PLOS

Causal effects of challenge and threat appraisals on pain self-efficacy, pain coping, and tolerance for laboratory pain: An experimental path analysis study.

PLoS One 2019 23;14(4):e0215087. Epub 2019 Apr 23.

Key Laboratory of Cognition & Personality Southwest University, Chongqing, China.

Background: Primary appraisals of pain as a potential threat influence pain perception and coping but comparatively less is known about related effects of challenge appraisals or causal effects of primary appraisals on secondary appraisals of perceived pain coping capacities (e.g., pain self-efficacy). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215087PLOS

Deep convolutional models improve predictions of macaque V1 responses to natural images.

PLoS Comput Biol 2019 Apr 23;15(4):e1006897. Epub 2019 Apr 23.

Centre for Integrative Neuroscience and Institute for Theoretical Physics, University of Tübingen, Tübingen, Germany.

Despite great efforts over several decades, our best models of primary visual cortex (V1) still predict spiking activity quite poorly when probed with natural stimuli, highlighting our limited understanding of the nonlinear computations in V1. Recently, two approaches based on deep learning have emerged for modeling these nonlinear computations: transfer learning from artificial neural networks trained on object recognition and data-driven convolutional neural network models trained end-to-end on large populations of neurons. Here, we test the ability of both approaches to predict spiking activity in response to natural images in V1 of awake monkeys. Read More

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http://dx.plos.org/10.1371/journal.pcbi.1006897
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http://dx.doi.org/10.1371/journal.pcbi.1006897DOI Listing
April 2019
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Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial.

PLoS Med 2019 Apr 23;16(4):e1002785. Epub 2019 Apr 23.

Xiangya School of Public Health, Central South University, Changsha, Hunan, China.

Background: Schizophrenia is a leading cause of disability, and a shift from facility- to community-based care has been proposed to meet the resource challenges of mental healthcare in low- and middle-income countries. We hypothesized that the addition of mobile texting would improve schizophrenia care in a resource-poor community setting compared with a community-based free-medicine program alone.

Methods And Findings: In this 2-arm randomized controlled trial, 278 community-dwelling villagers (patient participants) were randomly selected from people with schizophrenia from 9 townships of Hunan, China, and were randomized 1:1 into 2 groups. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002785DOI Listing

Mortality Rate-Dependent Variations in the Timing and Causes of Death in Extremely Preterm Infants Born at 23-24 Weeks' Gestation.

Pediatr Crit Care Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Objectives: To determine mortality rate-dependent variations in the timing and causes of death, and to subsequently identify the clinical factors associated with decreased mortality in extremely preterm infants born at 23-24 weeks' gestation.

Design: A retrospective cohort study.

Setting: Korean Neonatal Network registry that includes all level greater than or equal to 3 neonatal ICUs in Korea. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001913DOI Listing
April 2019
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Biomarkers of endothelial activation/dysfunction distinguish sub-groups of Ugandan patients with sepsis and differing mortality risks.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Background: Sepsis is a complex clinical syndrome with substantial heterogeneity. We sought to identify patterns of serum biomarkers of endothelial activation and dysfunction in individuals with sepsis and evaluate subgroup-specific differences in mortality.

Methods: Adult patients with sepsis (n=426) were consecutively recruited from two hospitals in Uganda. Read More

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http://dx.doi.org/10.1172/jci.insight.127623DOI Listing

Preparing for the Lurch into a Surgery Clerkship.

Heart Surg Forum 2019 Apr 18;22(2):E172-E179. Epub 2019 Apr 18.

Division of Cardiac Surgery, University of Virginia Health System, Charlottesville, Virginia, USA.

Over our combined nearly 50 years as surgical educators, we have been asked many times by medical students how they should prepare for and function in a Surgery Clerkship. It is still easy for me (C.G. Read More

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http://dx.doi.org/10.1532/hsf.2447DOI Listing

Primary Left Atrial Angiosarcoma Presenting as Acute Coronary Syndrome.

Heart Surg Forum 2019 Apr 12;22(2):E162-E164. Epub 2019 Apr 12.

Department of Cardiovascular Diseases, University Hospital Dubrava, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia.

Primary cardiac neoplasms are extremely rare and often overlooked as differential diagnosis. Angiosarcomas are the most common primary malignant neoplasms of the heart often with nonspecific symptoms. We present a 43-year-old woman admitted to our hospital with chest pain and inferoposterolateral myocardial infarction. Read More

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https://journal.hsforum.com/index.php/HSF/article/view/2381
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http://dx.doi.org/10.1532/hsf.2381DOI Listing
April 2019
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Survival of Patients with Primary Cardiac Tumors in an 11-Year Single Center Study.

Heart Surg Forum 2019 Feb 27;22(2):E097-E102. Epub 2019 Feb 27.

Department of Cardiac Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

Background: Primary cardiac tumors are rare, but few studies have examined the relationship between risk factors and the prognosis. The aim of this study was to provide a survival analysis and risk factors for mortality in patients with primary cardiac tumors.

Methods: We retrospectively enrolled 71 patients diagnosed with primary cardiac tumors from June 2006 to November 2017 in our hospital. Read More

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http://dx.doi.org/10.1532/hsf.2271DOI Listing
February 2019

Determining Which Prosthetic to Use During Aortic Valve Replacement in Patients Aged Younger than 70 Years: A Systematic Review of the Literature.

Heart Surg Forum 2019 Feb 28;22(2):E070-E081. Epub 2019 Feb 28.

University of Virginia School of Medicine, Charlottesville, VA., USA.

Background: The choice of bioprosthesis versus mechanical prosthesis in patients aged less than 70 years undergoing aortic valve replacement (AVR) remains controversial, with guidelines disparate in their recommendations. The objective of this study was to explore outcomes after AVR for various age ranges based on type of prosthesis.

Methods: A systematic review was undertaken according to the Preferred Reporting Instructions for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by using Medline (PubMed), Cochrane, Web of Science, Embase, and Scopus databases. Read More

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http://dx.doi.org/10.1532/hsf.2131DOI Listing
February 2019

Feasibility of Intensive Ecological Sampling of Tinnitus in Intervention Research.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844968. Epub 2019 Apr 23.

1 Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis School of Medicine, St Louis, Missouri, USA.

Objective: To assess whether adults with bothersome tinnitus will complete multiple ecological momentary assessments (EMAs) per day, including those during a therapeutic intervention trial. EMA is defined as repeated sampling of subjects' current behaviors and experiences in real time.

Study Design: Twelve-week longitudinal cohort study conducted from August 28, 2017, to December 14, 2017. Read More

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http://dx.doi.org/10.1177/0194599819844968DOI Listing

Systematic Review of Validated Quality of Life and Swallow Outcomes after Transoral Robotic Surgery.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844755. Epub 2019 Apr 23.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: To systematically review the available evidence on the effects of transoral robotic surgery (TORS) on the posttreatment quality of life (QOL) and swallow function of patients with head and neck cancer.

Data Sources: PubMed and Ovid electronic databases were searched from inception to July 6, 2016. Specific database functions were applied to maximize the search. Read More

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http://dx.doi.org/10.1177/0194599819844755DOI Listing

Randomized Phase II Trial to Compare the Efficacy of Haloperidol and Olanzapine in the Control of Chemotherapy-Induced Nausea and Vomiting in Nepal.

J Glob Oncol 2019 Apr(5):1-6

4 Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.

Purpose: The purpose of the study was to compare efficacy and toxicity of olanzapine (OLN; a higher-cost drug) and haloperidol (HAL; a lower-cost drug) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC).

Patients And Methods: In a randomized, phase II trial, patients were randomly assigned to receive either OLN 10 mg orally on days 1 to 4 or HAL 1 mg orally on day 1 and 0.5 mg twice daily on days 2 to 4. Read More

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http://dx.doi.org/10.1200/JGO.18.00245DOI Listing

Therapeutic Changes in Bilateral Choroidal Metastasis from Non-Small Cell Lung Cancer with Response to Afatinib: A Case Report.

Ocul Immunol Inflamm 2019 Apr 23:1-4. Epub 2019 Apr 23.

b Department of Ophthalmology , The Cancer Institute Hospital Of JFCR , Tokyo , Japan.

A 49-year-old male presented with a three-day onset of blurred vision and metamorphopsia in the left eye. Fundoscopy and OCT images identified multiple subretinal masses with associating serous retinal detachment in both eyes. Bilateral choroidal metastasis was suspected, and further evaluation revealed a mass in the lower left lobe of the lung with multiple metastatic loci. Read More

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http://dx.doi.org/10.1080/09273948.2019.1584322DOI Listing

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma.

J Clin Oncol 2019 Apr 23:JCO1802374. Epub 2019 Apr 23.

16 Monter Cancer Center, Northwell Health, Lake Success, NY, and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Purpose: SARC024 is a phase II clinical trial of the multikinase inhibitor regorafenib in specific sarcoma subtypes, including advanced osteosarcoma. We hypothesized that regorafenib would improve progression-free survival (PFS) in patients with sarcoma and report the results of the osteosarcoma cohort.

Patients And Methods: This trial enrolled patients with progressive metastatic osteosarcoma with measurable disease by RECIST who had received at least one prior line of therapy. Read More

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http://dx.doi.org/10.1200/JCO.18.02374DOI Listing

THE POTENTIAL CLINICAL APPLICATION OF A LOWER BILATERAL ADRENAL LIMB WIDTH RATIO (L/RW) IN PATIENTS WITH BILATERAL PRIMARY HYPERALDOSTERONISM.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: Department of Endocrinology and Metabolism, Adrenal Center, Sichuan University West China Hospital; Chengdu, Sichuan 610041, P. R. China.

Objective This study investigated the characteristics of the adrenal limbs of primary aldosteronism (PA) patients and evaluated the value of the adrenal limb width measurement for the differentiation of unilateral PA from bilateral PA. Methods A total of 122 PA patients (unilateral PA 93, ages ranged from 23 to 72years; bilateral PA 29, ages ranged from 30 to 68years) who had undergone successful adrenal venous sampling (AVS) and adrenal gland CT scan were retrospectively included. The maximum width of each adrenal gland limb (normal area on CT images) was measured, the left adrenal limb width to right adrenal limb width ratio (L/Rw) was calculated, and its potential value in the differentiation of unilateral PA and bilateral PA was analyzed. Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0009
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http://dx.doi.org/10.4158/EP-2019-0009DOI Listing
April 2019
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Current Workload Recommendations in Baseball Pitchers: A Systematic Review.

Am J Sports Med 2019 Apr 23:363546519831010. Epub 2019 Apr 23.

Department of Orthopedic Surgery, University of Michigan, Ypsilanti, Michigan, USA.

Background: Several recommendations have been made regarding pitch counts and workload for baseball players of different levels, including Little League, high school, collegiate, and professional baseball. However, little consensus is found in the literature regarding the scientific basis for many of these recommendations.

Purpose: The primary purpose of this study was to summarize the evidence regarding immediate and long-term musculoskeletal responses to increasing pitching workload in baseball pitchers of all levels. Read More

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http://dx.doi.org/10.1177/0363546519831010DOI Listing

Hole Trapping Process and Highly Sensitive Ratiometric Thermometry over a Wide Temperature Range in Pr-Doped NaLaTiO Layered Perovskite Micro-Crystals.

J Phys Chem A 2019 Apr 23. Epub 2019 Apr 23.

We demonstrate a potential optical thermometric material, Pr3+-doped triple-layered perovskite Na2La2Ti3O10 micro-crystals, which promises a remarkable performance in temperature sensing over a wide temperature range (125-533 K), with a maximum relative sensitivity of 2.43% K-1 at 423 K. Both temperature and high-pressure dependent photoluminescence measurements were performed for this compound. Read More

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http://pubs.acs.org/doi/10.1021/acs.jpca.9b01759
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http://dx.doi.org/10.1021/acs.jpca.9b01759DOI Listing
April 2019
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Impact of Grapevine Red Blotch disease on grape composition of Vitis vinifera Cabernet Sauvignon, Merlot and Chardonnay.

J Agric Food Chem 2019 Apr 23. Epub 2019 Apr 23.

Grapevine red blotch disease (GRBD) is a recently recognized viral disease that affects grapevines (Vitis vinifera L.). Currently little is known about its impact on grape composition. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b01125DOI Listing

Methodological Characteristics of Clinical Trials: Impact of Mandatory Trial Registration.

J Pharm Pharm Sci 2019 ;22(1):131-141

Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: Numerous studies across multiple specialties have evaluated the impact of trial registration on quality of study reports and found significant improvements over several domains. However, the impact of mandatory trial registration on the quality of clinical trial protocols remains hitherto unexplored.

Methods: We carried out a retrospective cohort study of clinical trial applications submitted to drug regulatory authority of India for initial review with the objective of comparing methodological characteristics of their protocols. Read More

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http://dx.doi.org/10.18433/jpps30360DOI Listing
January 2019

Optimal timing of endoscopic sinus surgery for odontogenic sinusitis.

Laryngoscope 2019 Apr 23. Epub 2019 Apr 23.

Department of Public Health Services, Henry Ford Health System, Detroit, Michigan, U.S.A.

Objectives: Odontogenic sinusitis (ODS) is more common than historically reported, and management recommendations are limited in the literature. Although ODS case series have shown successful outcomes with dental treatment and endoscopic sinus surgery (ESS), no studies have considered the optimal timing of these treatments. The purpose of this study was to analyze times to ODS resolution after primary dental treatment and ESS based on symptom, 22-item sinonasal outcome test (SNOT-22), and endoscopic outcomes. Read More

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http://dx.doi.org/10.1002/lary.28001DOI Listing

A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Maintenance of physical activity and sedentary behavior change, and physical activity and sedentary behavior change after an abridged intervention: Secondary outcomes from the ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: This brief report examines the maintenance of moderate to vigorous physical activity (MVPA) and sedentary behavior changes approximately 12 weeks after the delivery of the ACTIVATE Trial primary intervention (use of the Garmin Vivofit 2 activity tracker coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions). We also examine the efficacy of an abridged intervention (use of the Garmin Vivofit 2 only) in the waitlist control group.

Methods: A pre-post design was employed to examine the secondary aims of the ACTIVATE Trial (n = 80; mean age = 62 years). Read More

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http://dx.doi.org/10.1002/cncr.32142DOI Listing

A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Epigenetic abnormalities are manifold in all solid tumors and include changes in chromatin configuration and DNA methylation. The authors designed a phase 1 study to evaluate the oral DNA methyltransferase inhibitor CC-486 combined with the histone deacetylase inhibitor romidepsin in advanced solid tumors with dose expansion to further evaluate pharmacodynamics and possible clinical benefit of the recommended phase 2 dose (RP2D).

Methods: This was a phase 1 study with a 3 + 3 dose-escalation design and an expansion phase for patients with virally mediated cancers. Read More

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http://dx.doi.org/10.1002/cncr.32138DOI Listing

Trends in pediatric thyroid cancer incidence in the United States, 1998-2013.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Background: Pediatric differentiated thyroid cancer (DTC) rates have increased over time in the United States and worldwide. Improvements in imaging for the diagnosis of DTC have been hypothesized as a potential driver of these increases. This study stratifies temporal trends in pediatric DTC by stage and tumor size to assess whether rates of large, late-stage cancers, which are likely to be clinically meaningful, are increasing over time. Read More

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http://dx.doi.org/10.1002/cncr.32125DOI Listing

Hospital nurse-staffing models and patient- and staff-related outcomes.

Cochrane Database Syst Rev 2019 Apr 23;4:CD007019. Epub 2019 Apr 23.

Faculty of Science and Health, Dublin City University, Collins Avenue, Glasnevin, Dublin, Ireland, Dublin 9.

Background: Nurses comprise the largest component of the health workforce worldwide and numerous models of workforce allocation and profile have been implemented. These include changes in skill mix, grade mix or qualification mix, staff-allocation models, staffing levels, nursing shifts, or nurses' work patterns. This is the first update of our review published in 2011. Read More

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http://dx.doi.org/10.1002/14651858.CD007019.pub3DOI Listing
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