1,498,981 results match your criteria Primary Care Optometry News [Journal]


Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews.

Cochrane Database Syst Rev 2019 Feb 19;2:CD011890. Epub 2019 Feb 19.

School of Physiotherapy, The University of Notre Dame Australia, 19 Mouat Street (PO Box 1225), Fremantle, Western Australia, Australia, 6959.

Background: Chronic pain, considered to be pain lasting more than three months, is a common and often difficult to treat condition that can significantly impact upon function and quality of life. Treatment typically includes pharmacological and non-pharmacological approaches. Transcutaneous electrical nerve stimulation (TENS) is an adjunct non-pharmacological treatment commonly recommended by clinicians and often used by people with pain. Read More

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http://dx.doi.org/10.1002/14651858.CD011890.pub2DOI Listing
February 2019

Vasoactive Agents for the Management of Variceal Bleeding: A Mixed Treatment Comparison Network Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials.

Drug Res (Stuttg) 2019 Feb 18. Epub 2019 Feb 18.

School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji Islands.

Background: Vasoactives such as terlipressin, somatostatin, vasopressin, octreotide and nitrates are commonly used to treat variceal bleeding. The present study is a network meta-analysis comparing the efficacy and safety of the above vasoactive agents for treating variceal bleeding.

Methods: Electronic databases were searched for appropriate randomized clinical trials evaluating vasoactives in cirrhotic patients with variceal bleeding. Read More

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http://dx.doi.org/10.1055/a-0846-3071DOI Listing
February 2019

Characteristics of High Cardiovascular Risk in 1.7 Million Chinese Adults.

Ann Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Yale School of Medicine, New Haven, Connecticut (W.S., H.M.K.).

Background: As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited.

Objective: To assess the prevalence and treatment of high CVD risk as well as variations in risk across population subgroups. Read More

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http://dx.doi.org/10.7326/M18-1932DOI Listing
February 2019

A Cost-Effectiveness Analysis of Vaccination for Prevention of Herpes Zoster and Related Complications: Input for National Recommendations.

Ann Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Centers for Disease Control and Prevention, Atlanta, Georgia (R.H., A.G., I.R.O., F.Z., K.D.).

Background: The U.S. Advisory Committee on Immunization Practices recently developed recommendations for use of a new recombinant zoster vaccine (RZV). Read More

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http://dx.doi.org/10.7326/M18-2347DOI Listing
February 2019

A novel in vitro model of primary human pediatric lung epithelial cells.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Division of Neonatology, University of Rochester Medical Center, Rochester, NY, USA.

Background: Current in vitro human lung epithelial cell models derived from adult tissues may not accurately represent all attributes that define homeostatic and disease mechanisms relevant to the pediatric lung.

Methods: We report methods for growing and differentiating primary Pediatric Human Lung Epithelial (PHLE) cells from organ donor infant lung tissues. We use immunohistochemistry, flow cytometry, quantitative RT-PCR, and single cell RNA sequencing (scRNAseq) analysis to characterize the cellular and transcriptional heterogeneity of PHLE cells. Read More

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http://dx.doi.org/10.1038/s41390-019-0340-9DOI Listing
February 2019

Using spatially adaptive floating catchments to measure the geographic availability of a health care service: Pulmonary rehabilitation in the southeastern United States.

Health Place 2019 Feb 15;56:165-173. Epub 2019 Feb 15.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, United States.

A spatially adaptive floating catchment is a circular area that expands outward from a provider location until the estimated demand for services in the nearest population locations exceeds the observed number of health care services performed at the provider location. This new way of creating floating catchments was developed to address the change of spatial support problem (COSP) by upscaling the availability of the service observed at a provider location to the county-level so that its geographic association with utilization could be measured using the same spatial support. Medicare Fee-for-Service claims data were used to identify beneficiaries aged ≥ 65 years who received outpatient pulmonary rehabilitation (PR) in the Southeastern United States in 2014 (n = 8798), the number of PR treatments these beneficiaries received (n = 132,508), and the PR providers they chose (n = 426). Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.01.017DOI Listing
February 2019

Increased survival of non low-grade and deep-seated soft tissue sarcoma after surgical management in high-volume hospitals: a nationwide study from the Netherlands.

Eur J Cancer 2019 Feb 15;110:98-106. Epub 2019 Feb 15.

Department of Surgical Oncology, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015GD, Rotterdam, the Netherlands. Electronic address:

Background: Diagnosing and treating soft tissue sarcomas (STSs) remains challenging, stressing the urgency for centralisation. This nationwide survey aimed to evaluate the centralisation of STS surgery and its effect on survival.

Methods: Patients operated for primary STS from 2006 to 2015 were queried from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.005DOI Listing
February 2019

Structural investigation of α-l-fucosidase from the pancreas of Patiria pectinifera, based on molecular cloning.

Carbohydr Res 2019 Feb 7;475:27-33. Epub 2019 Feb 7.

Department of Applied Chemistry and Biochemistry, National Institute of Technology, Fukushima College, 30 Nagao, Iwaki, Fukushima, 970-8034, Japan. Electronic address:

An α-l-fucosidase (Pap-Alf) was purified from the pancreas of a starfish Patiria pectinifera by ammonium sulfate precipitation followed by several column chromatographies. The molecular mass of the purified enzyme was estimated to be 52.6 kDa by SDS-PAGE, although gel filtration analysis of the native enzyme suggests it exists as a homodimer in solution. Read More

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http://dx.doi.org/10.1016/j.carres.2019.02.001DOI Listing
February 2019

Non-pharmacological therapies for depressive symptoms in breast cancer patients: Systematic review and meta-analysis of randomized clinical trials.

Breast 2019 Jan 31;44:135-143. Epub 2019 Jan 31.

DPH, Instituto Nacional de Salud Pública, Av. Universidad 655, Sta. Ma. Ahuacatitlán, C.P. 62100, Cuernavaca, Morelos, Mexico. Electronic address:

Objective: Depressive symptoms are common comorbidities among breast cancer (BC) patients. Non-pharmacological therapies (NPTs) such as exercise and psychotherapy may reduce depressive symptoms; however, the evidence is inconclusive. The objective of this study is to evaluate if NPTs reduce depressive symptoms among BC patients. Read More

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http://dx.doi.org/10.1016/j.breast.2019.01.006DOI Listing
January 2019

Generation of human iPSCs from fetal prostate fibroblasts HPrF.

Stem Cell Res 2019 Feb 7;35:101405. Epub 2019 Feb 7.

Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address:

Human induced pluripotent stem cell line was generated from commercially available primary human prostate fibroblasts HPrF derived from a fetus, aged 18-24 weeks of gestation. The fibroblast cell line was reprogrammed with Yamanaka factors (OCT4, SOX2, c-MYC, KLF4) using CytoTune™-iPS 2.0 Sendai Reprogramming Kit. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101405DOI Listing
February 2019

Generation of induced pluripotent stem cell line (ZZUi0012-A) from a patient with Fahr's disease caused by a novel mutation in SLC20A2 gene.

Stem Cell Res 2019 Jan 28;35:101395. Epub 2019 Jan 28.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Several SLC20A2 mutations have been implicated as potential causes of Fahr's disease, a subtype of primary familial brain calcification (PFBC), but very few patient-derived induced pluripotent stem cell (iPSC) models have been established. We have identified a novel SLC20A2 mutation in a family with Fahr's disease. We subsequently obtained dermal fibroblasts from a patient in this family. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101395DOI Listing
January 2019

Antipsychotic-minocycline-acetylcysteine combination for positive, cognitive, and negative symptoms of schizophrenia.

Asian J Psychiatr 2019 Feb 12;40:100-102. Epub 2019 Feb 12.

Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, 2300 I St NW, 20037, Washington, DC, USA. Electronic address:

Preclinical evidence shows that the minocycline and N-acetylcysteine (NAC) combination synergistically improved cognition. Meta-analyses of randomized controlled trials (RCTs) with minocycline and NAC have shown some efficacy signal for positive, cognitive, and negative symptoms of schizophrenia. Hence, the combination may be more effective than either medication alone. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.007DOI Listing
February 2019

Aqueous two-phase extraction of R-Phycoerythrin from marine macro-algae, Gelidium pusillum.

Bioresour Technol 2019 Feb 10;280:277-286. Epub 2019 Feb 10.

Academy of Scientific and Innovative Research (AcSIR), Department of Food Engineering, CSIR-Central Food Technological Research Institute (CSIR-CFTRI), Mysore, India. Electronic address:

Aqueous two-phase extraction (ATPE) of R-Phycoerythrin (R-PE), a fluorescent and commercially valuable protein, was carried out in two parallel schemes. In scheme-1, ATPE alone was employed, and in scheme-2, process-integration was attempted, where primary extract was subjected to precipitation before standardization of process parameters of ATPE. Scheme-1 with polyethylene glycol (PEG)-3350/potassium phosphate system has resulted in very low R-PE yield (26% w/w) without much enrichment in purity (0. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.044DOI Listing
February 2019

Beneficial effects of Coomassie staining on proteomic analysis employing PAGE separation followed with whole-gel slicing, in-gel digestion and quantitative LC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 11;1110-1111:25-35. Epub 2019 Feb 11.

Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, PR China. Electronic address:

Proteomic analysis by combining PAGE separation, gel slicing and slice-by-slice in-gel digestion and LC-MS/MS has been frequently reported in recent years. Since the MS analysis would provide identities and quantities of the proteins along the whole lane, gel visualization by dye staining could be skipped to save time and labor. In this work, we examined the effects of CBB R-250 staining on the performance of the method and the results showed actually better results were obtained with CBB staining than without, both in nondenaturing PAGE and SDS-PAGE. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.031DOI Listing
February 2019

Quantification of second generation direct-acting antivirals daclatasvir, elbasvir, grazoprevir, ledipasvir, simeprevir, sofosbuvir and velpatasvir in human plasma by UPLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 28;1110-1111:15-24. Epub 2019 Jan 28.

Dept of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.

Direct-acting antivirals (DAA) have markedly improved the treatment of hepatitis C, with a series of DAA combinations available for treatment. A sensitive method by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous quantification of seven commonly used DAAs, daclatasvir (DAC), elbasvir (ELB), grazoprevir (GZR), ledipasvir (LDV), simeprevir (SIM), sofosbuvir (SOF), velpatasvir (VEL) and the primary analyte of interest of SOF (GS-331007) in EDTA plasma. Adequate chromatographic separation with well-defined peaks for all eight analytes was achieved with an Acquity UPLC BEH C18 column (1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.024DOI Listing
January 2019

Chemometric analysis of Amaranthus retroflexus in relation to livestock toxicity in southern Australia.

Phytochemistry 2019 Feb 15;161:1-10. Epub 2019 Feb 15.

Graham Centre for Agricultural Innovation (Charles Sturt University and NSW Department of Primary Industries), Wagga Wagga, NSW, 2650, Australia; Charles Sturt University, School of Agricultural and Wine Sciences, Wagga Wagga, NSW, 2678, Australia.

Amaranthus retroflexus L., an introduced invasive weed in southern Australia, has been associated with acute renal failure and/or mortality in a number of livestock species. While its leaves, flowers and stems are generally reported to contain high levels of nitrogen, few studies have fully characterised the chemical composition of A. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.01.016DOI Listing
February 2019

Revised management of advanced primary colon cancer: Case series of 2 patients.

Int J Surg Case Rep 2019 Feb 10;55:233-238. Epub 2019 Feb 10.

Department of Surgery, MedStar Washington Hospital Center, Washington, DC, USA.

Background: The resection of a primary colon cancer has the opportunity to cure the patient of cancer by complete clearance and absolute containment of disease. Alternatively, if the cancer resection does not provide clearance and containment it will eventuate in local recurrence and peritoneal dissemination.

Methods: Culpability of recurrence of colorectal cancer is difficult to determine. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.046DOI Listing
February 2019

Environmental sustainability of anaerobic digestion of household food waste.

J Environ Manage 2019 Feb 15;236:798-814. Epub 2019 Feb 15.

Sustainable Industrials Systems, School of Chemical Engineering and Analytical Science, The University of Manchester, Manchester, M13 9PL, UK.

Consumers are the leading producers of food waste (FW) in developed countries and the majority of household FW is still embedded in general waste where it is incinerated or landfilled. There is increasing awareness in the value of collecting FW as a separate waste stream for production of compost or recovery of energy through anaerobic digestion (AD). This study focuses on AD to evaluate the life cycle environmental sustainability of recovering energy and fertilisers from household FW in the UK. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.001DOI Listing
February 2019

The Surprise Question Can Be Used to Identify Heart Failure Patients in the Emergency Department Who Would Benefit from Palliative Care.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Division of Palliative Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School.

Context: Heart Failure (HF) is associated with symptom exacerbations and risk of mortality after an emergency department (ED) visit. While emergency physicians (EPs) treat symptoms of HF, often the opportunity to connect with palliative care is missed. The 'Surprise Question' (SQ), "would you be surprised if this patient died in the next 12 months?" is a simple tool to identify patients at risk for 12-month mortality. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.007DOI Listing
February 2019

I feel what I do: Relating interoceptive processes and reward-related behavior.

Neuroimage 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychology, General and Experimental Psychology Unit, Ludwig-Maximilians University, D-80802, Munich, Germany.

Interoceptive signalling has been shown to contribute to action regulation and action experience. Here, we assess whether motor behaviour can be influenced by anticipated homeostatic feeling states induced through different predictable contexts. Participants performed a reward incentive paradigm in which accurate responses increased (gain) or avoided the depletion (averted loss) of a credit score. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.032DOI Listing
February 2019

The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Patient registries are instrumental for clinical research in rare diseases. They help to achieve a sufficient sample size for epidemiological and clinical research and to assess the feasibility of clinical trials. The European Society for Immunodeficiencies (ESID) registry currently comprises information on >25,000 patients with inborn errors of immunity (IEI). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.004DOI Listing
February 2019

Increased proportions of γδ T lymphocytes in atypical SCID associate with disease manifestations.

Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of γδ T lymphocytes have been reported. However, it is unknown whether these γδ T cells modulate or reflect the patient's clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2018.11.006DOI Listing
February 2019

Direct oral anticoagulants in patients undergoing spine surgery.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland.

Object: Despite the increasing use of DOACs, guidelines for their perioperative use in spine surgery are still lacking. The main goal of our study was to analyze the occurrence of postoperative bleeding events and possible confounders in patients treated with DOACs who undergo spine surgery.

Material And Methods: Out of 2777 patients undergoing spine surgery at our institution, 82 (2. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.236DOI Listing
February 2019

A meta-analysis of endoscopic microvascular decompression versus microscopic microvascular decompression for the treatment for cranial nerve syndrome caused by vascular compression.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Departments of Neurosurgery and Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Objective: The aim of this study was to compare the efficacy and safety of endoscopic microvascular decompression (E-MVD) and microscopic microvascular decompression (M-MVD) for the treatment for cranial nerve syndrome caused by vascular compression, including primary trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia.

Methods: A systematic search of the online databases, including PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China Biology Medicine disc, and China National Knowledge Infrastructure, was performed from January 1966 to March 2018. The language of the included literature was not limited. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.220DOI Listing
February 2019

Proteome changes in methylmercury-exposed mouse primary cerebellar granule neurons and astrocytes.

Toxicol In Vitro 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology, University of Ottawa, Canada. Electronic address:

Methylmercury (MeHg) is a neurotoxicant, with the cerebellum as the main target of toxicity; however, the toxic effects of MeHg on specific cell types remain unclear. Here, primary cerebellar granule neurons (CGNs) and cerebellar astrocytes were isolated and analyzed for total mercury accumulation, cellular reactive oxygen species (ROS) production, and whole-cell proteome expression after exposure to 0-10 μM MeHg for 24 h. Intracellular mercury and ROS levels showed dose-dependent increases. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.013DOI Listing
February 2019

Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells.

Bone 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology and Metabolism, Medical School, University of Sheffield, UK. Electronic address:

Multiple myeloma (MM) is characterised by destructive lytic bone disease, caused by induction of bone resorption and impaired bone formation. Our understanding of the molecular mechanisms responsible for osteoblast suppression, are limited. Using the 5T2MM murine model of MM we have previously shown that suppression of the activity of a known inhibitor of bone formation Dikkopf-1 (Dkk1) prevents the development of lytic bone disease. Read More

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http://dx.doi.org/10.1016/j.bone.2019.02.012DOI Listing
February 2019

The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates.

Neurosci Lett 2019 Feb 15. Epub 2019 Feb 15.

Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. Electronic address:

Background: Alpha-synuclein (αSN) is an abundant presynaptic brain protein that its aggregated species believed to play pivotal roles in the development of neurodegenerative diseases, especially Parkinson's disease (PD). In this study, we compared the response of primary neuronal cells with a well-known cell line model, PC12, against the toxic aggregates of αSN.

Methods: Primary hippocampal neurons (PHNs) were isolated from 17 to 18 days old rat embryos. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.055DOI Listing
February 2019

Genome characterization and temporal evolution analysis of a non-epidemic norovirus variant GII.8.

Infect Genet Evol 2019 Feb 15. Epub 2019 Feb 15.

Guangdong Institute of Microbiology, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangzhou 510070, PR China. Electronic address:

Noroviruses are the primary cause of non-bacterial acute gastroenteritis worldwide, and GII.8 belongs to a non-epidemic genotype with a limited understanding currently. In this study, we assembled the first GII. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.02.010DOI Listing
February 2019

Endoplasmic reticulum proteostasis control and gastric cancer.

Cancer Lett 2019 Feb 15. Epub 2019 Feb 15.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

The endoplasmic reticulum (ER) is the primary organelle responsible for the synthesis, modification, folding and secretion of proteins, especially in specialized secretory cells. It also contributes to the maintenance of cellular functions, such as Ca storage, lipogenesis, gluconeogenesis, and organelle biogenesis. Cellular stress conditions, such as glucose deprivation, hypoxia and disturbance of Ca homeostasis, may increase the risk of protein misfolding and perturb proteostasis. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.034DOI Listing
February 2019

NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.

Cancer Lett 2019 Feb 15. Epub 2019 Feb 15.

Seattle Children's Research Institute, Center for Global Infectious Disease Research, 1900 Ninth Ave., Seattle, WA, 98101-1309, USA; Dept. of Global Health, Pathobiology Program, University of Washington, Seattle, WA, USA; Dept. of Pediatrics, Div. of Adolescent Medicine, University of Washington, Seattle, WA, USA. Electronic address:

A significant contributor to women's cancer mortality worldwide is cervical cancer, which is caused by high-risk human papillomavirus (HR HPV). The two viral oncoproteins of HR HPV, E6 and E7, partner with host cell proteins to target oncogenic proteins and pathways. Previously, we have shown HR HPV type 16 E6 (16E6) interacts with the host protein NFX1-123 to target telomerase and cellular immortalization, requiring NFX1-123 to fully upregulate telomerase activity. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.024DOI Listing
February 2019

IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

NBO, INRA, Univ Paris-Saclay, 78350 Jouy-en-Josas, France; Université de Versailles Saint-Quentin en Yvelines, 78000 Versailles, France. Electronic address:

At the interface of the environment and the nervous system, the olfactory mucosa (OM) is a privileged pathway for environmental toxicants and pathogens towards the central nervous system. The OM is known to produce antimicrobial and immunological components but the mechanisms of action of the immune system on the OM remain poorly explored. IL-17c is a potent mediator of respiratory epithelial innate immune responses, whose receptors are highly expressed in the OM of mice. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.012DOI Listing
February 2019

Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes.

Gene 2019 Feb 15. Epub 2019 Feb 15.

Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu 641114, India; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

Background: Parkinson's disease (PD) is a complex neurodegenerative movement disorder that primarily results due to the loss of dopaminergic neurons in the substantia nigra region. Studying gene expression in the substantia nigra region would potentially unravel disease-relevant protein-protein interactions.

Methods: In this study we have used network science approach to prioritize candidate genes by focussing on differentially expressed genes (DEGs) that interact with established PD associated-genes (PDAG). Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.026DOI Listing
February 2019
1 Read

TELOMERE LENGTH AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL STUDIES.

Ageing Res Rev 2019 Feb 15. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Ambulatory of Nutrition, IRCCS "S. de Bellis" National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
February 2019
4.940 Impact Factor

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

Int J Radiat Oncol Biol Phys 2019 Feb 15. Epub 2019 Feb 15.

Radiation Oncology Department, CHUV Lausanne, Switzerland.

Purpose: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

Methods And Materials: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.024DOI Listing
February 2019

Nicotinamide Metabolism Modulates the Proliferation / Differentiation Balance and Senescence of Human Primary Keratinocytes.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Cell Cycle Control in Skin Epidermis, Skin Research Institute of Singapore, A*STAR, 8A Biomedical Grove, Singapore 138648; School of Biological Sciences & Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637551. Electronic address:

Nicotinamide (NAM) is the main precursor of NAD, a co-enzyme essential for DNA repair, glycolysis and oxidative phosphorylation (OXPHOS). NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3D organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the basal layer. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.005DOI Listing
February 2019

Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Dept. of Pharmacology and Systems Physiology, University of Cincinnati, United States; Neuroscience Graduate Program, University of Cincinnati, United States; VA Medical Center, Cincinnati, OH, 45221, United States. Electronic address:

Individuals with fear-associated conditions such as panic disorder (PD) and posttraumatic stress disorder (PTSD) display increased emotional responses to interoceptive triggers, such as CO inhalation, that signal a threat to physiological homeostasis. Currently, effector systems and mechanisms underlying homeostatic modulation of fear memory are not well understood. In this regard, the renin angiotensin system (RAS), particularly the angiotensin receptor type 1 (AT1R), a primary homeostatic regulatory target, has gained attention. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.02.007DOI Listing
February 2019

Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.

J Control Release 2019 Feb 15. Epub 2019 Feb 15.

Departments of Pediatrics, Physiology and Pharmacology, University of Montréal, Montréal, QC, Canada. Electronic address:

Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.014DOI Listing
February 2019

Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens.

J Pharm Sci 2019 Feb 15. Epub 2019 Feb 15.

International AIDS Vaccine Initiative, New York, NY 10004 USA. Electronic address:

The induction of broadly neutralizing antibodies (bNAb) is a major goal in the development of an effective vaccine against HIV-1. A soluble, trimeric, germline (gI) bNAb-targeting variant of the HIV-1 envelope glycoprotein (termed BG505 SOSIP.v4. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.01.033DOI Listing
February 2019

Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons.

Neuropharmacology 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, The University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA. Electronic address:

Receptor heteromers often display distinct pharmacological and functional properties compared to the individual receptor constituents. In this study, we compared the properties of the DOP-KOP heteromer agonist, 6'-guanidinonaltrindole (6'-GNTI), with agonists for DOP ([D-Pen2,5]-enkephalin [DPDPE]) and KOP (U50488) in peripheral sensory neurons in culture and in vivo. In primary cultures, all three agonists inhibited PGE-stimulated cAMP accumulation as well as activated extracellular signal-regulated kinase 1/2 (ERK) with similar efficacy. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.019DOI Listing
February 2019

Rapid detection of methicillin-resistant Staphylococcus aureus in bronchoalveolar lavage: A pilot randomized controlled trial.

Chest 2019 Feb 15. Epub 2019 Feb 15.

Northwestern University Feinberg School of Medicine, Department of Medicine, Pulmonary and Critical Care Division, Chicago, IL. Electronic address:

Background: Guidelines recommend empirical vancomycin or linezolid for suspected pneumonia patients at-risk for methicillin-resistant Staphylococcus aureus (MRSA). Unneeded vancomycin or linezolid use may unnecessarily alter host flora and expose patients to toxicity. We therefore sought to determine if rapid testing for MRSA in bronchoalveolar lavage (BAL) can safely decrease use of vancomycin or linezolid for suspected MRSA pneumonia. Read More

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http://dx.doi.org/10.1016/j.chest.2019.02.007DOI Listing
February 2019

Prospective Multicentered Safety and Feasibility Pilot for Endobronchial Intratumoral Chemotherapy.

Chest 2019 Feb 15. Epub 2019 Feb 15.

Section of Interventional Pulmonology, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Durham, NC.

Background: Malignant airway obstruction (MAO) occurs in 30% of patients with advanced stage lung cancer leading to debilitating dyspnea, cough and hemoptysis. Other than recanalization of the airways, these patients lack long-lasting palliative therapy. The goal of this study was to determine the safety and feasibility of local injection of paclitaxel into the airway wall with a novel microinjection catheter. Read More

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http://dx.doi.org/10.1016/j.chest.2019.02.006DOI Listing
February 2019

Primary Oral Presentation of Sarcoidosis in a Pediatric Patient.

J Oral Maxillofac Surg 2019 Jan 23. Epub 2019 Jan 23.

Associate Professor, Department of Pediatric Rheumatology, Children's of Alabama, Birmingham, AL.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology that commonly affects the lungs, lymph nodes, and skin. The disease often presents in patients between the third and sixth decade and its pathology is defined by the presence of noncaseating granulomas within organs throughout the body. Oral and neurologic involvement of sarcoid is extremely rare and occurs in approximately 1% and 5% of patients with the disease, respectively. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.018DOI Listing
January 2019

Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Feb 18. Epub 2019 Feb 18.

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

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http://dx.doi.org/10.1093/humrep/dey393DOI Listing
February 2019

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial.

JAMA 2019 Feb;321(7):665-675

Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom.

Importance: A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%.

Objective: To determine whether a nurse-led preventive, complex psychological intervention, initiated in the ICU, reduces patient-reported PTSD symptom severity at 6 months.

Design, Setting, And Participants: A multicenter, parallel-group, cluster-randomized clinical trial with integrated economic and process evaluations conducted in 24 ICUs in the United Kingdom. Read More

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http://dx.doi.org/10.1001/jama.2019.0073DOI Listing
February 2019

Comorbidities in primary versus secondary school children with obesity and responsiveness to lifestyle intervention.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Paediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands.

Context: Childhood obesity increases the risk of diseases as diabetes, cardiovascular disease and non-alcoholic fatty liver disease.

Objective: To evaluate the prevalence of comorbidities in school-age children with obesity and to compare its prevalence and the effect of a lifestyle intervention between children in primary and secondary school and between boys and girls.

Design: Cross-sectional analysis and lifestyle intervention. Read More

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http://dx.doi.org/10.1210/jc.2018-02318DOI Listing
February 2019

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free From Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA 2019 Feb 18. Epub 2019 Feb 18.

Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Importance: Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure might attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome (ARDS).

Objective: To determine whether PEEP titration guided by esophageal pressure (PES), an estimate of pleural pressure, was more effective than empirical high PEEP-fraction of inspired oxygen (Fio2) in moderate to severe ARDS.

Design, Setting, And Participants: Phase 2 randomized clinical trial conducted at 14 hospitals in North America. Read More

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http://dx.doi.org/10.1001/jama.2019.0555DOI Listing
February 2019

Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.

Acta Otolaryngol 2018 Nov;138(11):1043-1050

a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.

Background: Open laryngeal function-preserving surgery is a common therapeutic strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients.

Objectives: To explore the fundamental clinical characteristics and survival prognostic factors of LSCC patients treated with open laryngeal function-preserving operations.

Material And Methods: about a total of 659 LSCC patients undergoing open laryngeal function-preserving operations were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/00016489.2018.1500711DOI Listing
November 2018

Does drug induced sleep endoscopy-directed surgery improve polysomnography measures in children with Down Syndrome and obstructive sleep apnea?

Acta Otolaryngol 2018 Nov;138(11):1009-1013

c Pediatric Otolaryngology , Seattle Children's Hospital , Seattle , WA , USA.

Background: Children with Down Syndrome (DS) and obstructive sleep apnea (OSA) are difficult to treat, as first line therapies may not lead to significant improvement. Drug-induced sleep endoscopy (DISE) directed surgery may be particularly beneficial for these patients.

Objective: To assess change in polysomnography (PSG) measures of patients with DS who underwent DISE-directed surgery. Read More

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http://dx.doi.org/10.1080/00016489.2018.1504169DOI Listing
November 2018

[Activity of metabolic enzymes of saliva with neuroendocrine tumors of the lung of various degrees of malignancy.]

Klin Lab Diagn 2018 ;63(11):677-682

University Hospital of Strasbourg, Strasbourg.

Up to the present time, problems of optimizing the methods of diagnosis and predicting the course of lung cancer, which occupies the leading positions in the structure of oncological diseases, remain topical. The purpose of the study was to study the characteristics of the activity of metabolic salivary enzymes in neuroendocrine tumors of the lung, depending on the degree of malignancy. In the casecontrol study, 156 people took part, divided into 2 groups: primary (neuroendocrine lung tumors, n=56) and control (conventionally healthy, n=100). Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-11-677-682DOI Listing
January 2018

[Biological function of endoecology (cleanliness of intercellular environment) realize two biolocical reactions: excretion reaction and inflammation reaction - utilization in vivo, in situ catabolites of the large molecular mass.]

Authors:
V N Titov

Klin Lab Diagn 2018 ;63(11):668-676

National Medical Research Center of Cardiology, Ministry of Health, 121552, Moscow, Russia.

For the biological functions of trophology (nutrition) and homeostasis, we believe that the third place is occupied by the function of endoecology: in a single pool of intercellular environment in vivo it must be "pure". The biological function of endoecology, realizes two biological reactions: the reaction of excretion and the reaction of inflammation. The biological reaction of excretion is the filtration of phlogogens of a small mol. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-11-668-676DOI Listing
January 2018
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