1,480,184 results match your criteria Primary Care Diabetes [Journal]


[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

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October 2018
1 Read

[Natural history after discharge from a hospital psychosomatic treatment - Results of a one-year follow-up].

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Zentrum für Psychiatrie Südwürttemberg, Abteilung Psychosomatische Medizin Ravensburg.

Background: The effectiveness of the inpatient psychosomatic treatment has been documented in various settings. The question of the sustainability of the improvement achieved as well as the prognostic factors is of interest for public health.

Objective: Primary outcome variables reflect the stability or change in the clinical status of patients one year after the discharge from the inpatient psychosomatic treatment. Read More

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December 2018

[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018
1 Read

Functional expansion of a TCA cycle operon mRNA by a 3' end-derived small RNA.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

RNA Biology Group, Institute for Molecular Infection Biology, University of Würzburg, D-97080 Würzburg, Germany.

Global RNA profiling studies in bacteria have predicted the existence of many of small noncoding RNAs (sRNAs) that are processed off mRNA 3' ends to regulate other mRNAs via the RNA chaperones Hfq and ProQ. Here, we present targets of SdhX (RybD), an Hfq-dependent sRNA that is generated by RNase E mediated 3' processing of the ∼10 000-nt mRNA of the TCA cycle operon sdhCDAB-sucABCD in enteric bacteria. An in silico search predicted ackA mRNA, which encodes acetate kinase, as a conserved primary target of SdhX. Read More

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December 2018

Oocyte-Secreted Factors Synergize with FSH to Promote Aromatase Expression in Primary Human Cumulus Cells.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology and Biophysics, University of Illinois at Chicago.

Context: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.

Objective: Determine GDF9 and BMP15 effects on follicle-stimulating hormone (FSH) stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression. Read More

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December 2018

Classification of chronic kidney disease 10 years on: what have we learnt in the Netherlands.

Fam Pract 2018 Dec;35(6):744-745

Department of Primary and Community Care, Radboud university medical center, Nijmegen, the Netherlands.

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December 2018

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines.

Am J Clin Nutr 2018 Dec;108(6):1357-1368

School of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, Canada.

The Government of Canada and the Society of Obstetricians and Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 µg folic acid (FA) for the primary prevention of neural tube defects among low-risk women from before conception and throughout lactation. Prenatal supplements marketed and prescribed in Canada typically exceed the recommended dose, usually providing ≥1000 µg FA/d. This high daily dose, coupled with staple-food FA fortification, has resulted in the observation of very high blood folate concentrations among reproductive-aged women consuming FA-containing supplements. Read More

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December 2018

An exploration of the longitudinal relation between parental feeding practices and child anthropometric adiposity measures from the West Midlands Active Lifestyle and Healthy Eating in Schoolchildren (WAVES) Study.

Am J Clin Nutr 2018 Dec;108(6):1316-1323

Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

Background: Some research suggests that parent or carer feeding practices may influence children's weight patterns, but longitudinal evidence is limited and inconsistent.

Objective: The aim of this study was to investigate the relation between various parent or carer feeding practices when a child is aged 7-8 y and proxy measurements of child adiposity at age 8-9 y (weight status, waist-to-height ratio, and body fat percentage).

Design: The study was a secondary analysis of data from the West Midlands Active Lifestyle and Healthy Eating in Schoolchildren (WAVES) Study comprising a diverse sample of parents and carers and their children from 54 primary schools in the West Midlands, England [n = 774 parent-child dyads (53% of the WAVES study sample)]. Read More

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December 2018

Associations between general practice characteristics with use of urgent referrals for suspected cancer and endoscopies: a cross-sectional ecological study.

Fam Pract 2018 Dec 12. Epub 2018 Dec 12.

The Health Improvement Institute (THIS), University of Cambridge, Cambridge, UK.

Background: Large variation in measures of diagnostic activity has been described previously between English general practices, but related predictors remain understudied.

Objective: To examine associations between general practice population and characteristics, with the use of urgent referrals for suspected cancer, and use of endoscopy.

Methods: Cross-sectional observational study of English general practices. Read More

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December 2018

Targeting cervical cancer campaigns on teenage high schoolers in resource-limited economies: lessons from an intervention study of Nigerian senior secondary school girls.

Fam Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Community Medicine and Primary Healthcare, Chukwuemeka Odumegwu Ojukwu University/University Teaching Hospital, Awka, Nigeria.

Background: Given the dearth of government-sponsored programmes, preventive lifestyles and practices are the realistic hopes for millions of women in developing countries against cervical cancer. Early interventions for teenage high school girls have been advocated recently, but evidence-base for sustainable activities at this demographic is lacking. This article reduces this gap by determining the impact of two cervical cancer education techniques. Read More

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December 2018

Turning Pain into Gain: Evaluation of a Multidisciplinary Chronic Pain Management Program in Primary Care.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Queensland 4222, Australia and Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland 4222, Australia.

Objective: To measure the impact of the multidisciplinary Turning Pain Into Gain program in people experiencing chronic pain of any etiology.

Methods: A mixed-methods observational study of 252 participants was used to explore the impact of Turning Pain Into Gain on medication use; quality of life and functioning, as measured by the Pain Self-Efficacy Questionnaire; and self-reported hospitalizations between 2015 and 2016.

Results: Responses from 178 participants showed an increased alignment with Australian pain medication guidelines (e. Read More

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December 2018

Functionally distinct assembly of vascular plants colonizing alpine cushions suggests their vulnerability to climate change.

Ann Bot 2018 Dec 12. Epub 2018 Dec 12.

Institute of Botany, The Czech Academy of Sciences, Průhonice, Czech Republic.

Background And Aims: Alpine cushion plants can initially facilitate other species during ecological succession, but later on can be negatively affected by their development, especially when beneficiaries possess traits allowing them to overrun their host. This can be reinforced by accelerated warming favouring competitively strong species over cold-adapted cushion specialists. However, little empirical research has addressed the trait-based mechanisms of these interactions. Read More

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December 2018
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Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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December 2018

Intra-articular Steroids vs Saline for Lumbar Z-Joint Pain: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, Tennessee.

Objective: To determine if intra-articular (IA) injection of corticosteroids is effective in reducing the need for radiofrequency ablation (RFA) in those with dual comparative medial branch block (MBB)-confirmed lumbar z-joint pain.

Design: This was a randomized, double blind, placebo-controlled study.

Setting: Two academic medical centers. Read More

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December 2018
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Examining associations between physical activity and cardiovascular mortality using negative control outcomes.

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Charles Perkins Centre, University of Sydney, Sydney, Australia.

Background: The purpose of a negative control is to reproduce a condition that cannot involve the hypothesized causal mechanism, but does involve the same sources of bias and confounding that may distort the primary association of interest. Observational studies suggest physical inactivity is a major risk factor for cardiovascular disease (CVD), although potential sources of bias, including reverse causation and residual confounding, make it difficult to infer causality. The aim was to employ a negative control outcome to explore the extent to which the association between physical activity and CVD mortality is explained by confounding. Read More

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December 2018

TNM classification of malignant tumors (Breast Cancer Study Group).

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

The eighth editions of the primary tumor, lymph node and metastasis classifications for breast cancer issued by the American Joint Commission of Cancer and the Union for International Cancer Control were revised in 2017. The major change made by the American Joint Commission of Cancer is to incorporate biological factors such as estrogen and progesterone receptor, human epidermal growth factor receptor 2, histological grade and multigene prognostic assays, into the staging system. Tumor biomarkers and low recurrence scores confirmed by multigene prognostic assays change the staging. Read More

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December 2018

DNA damage and repair in the female germline: contributions to ART.

Hum Reprod Update 2018 Dec 12. Epub 2018 Dec 12.

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW, Australia.

Background: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. Read More

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December 2018
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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Population Health Sciences, University of Bristol, Bristol, UK.

Background: Accumulating evidence suggests that breastfeeding benefits children's intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, an interaction between breastfeeding and genetic variants associated with endogenous LC-PUFAs synthesis might be expected. However, the literature on this topic is controversial. Read More

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December 2018
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Management of paediatric patients with medically-refractory Crohn's disease using Ustekinumab: A multi-centred cohort study.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, Montreal Children's Hospital, Department of Paediatrics, McGill University, Montreal, Quebec, Canada.

Background: Ustekinumab (UST) is effective in the treatment of adults with moderate to severe Crohn's disease (CD). There is a paucity of data on its use in children.

Aim: To evaluate the response to UST in children with moderate to severe CD. Read More

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December 2018
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Thyroid Sequelae of Pediatric Cancer Therapy.

Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

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December 2018
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Effects of the Lidcombe Program and Parent-Child Interaction Therapy on Stuttering Reduction in Preschool Children.

Folia Phoniatr Logop 2018 Dec 12;71(1):29-41. Epub 2018 Dec 12.

Department of Communication Sciences and Disorders, Bowling Green State University, Bowling Green, Ohio, USA.

Purpose: The present study explored the effectiveness of the Lidcombe Program, the parent-child interaction therapy (PCIT) approach, and an integrated (Lid-PCIT) program on the treatment of children who stutter.

Methods: The present research was a single-subject study with an alternative treatment design. Participants were 6 preschool children who were randomly assigned into three groups. Read More

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December 2018
0.550 Impact Factor

Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study.

Ann Nutr Metab 2018 Dec 12;74(1):35-43. Epub 2018 Dec 12.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. Read More

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December 2018

Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis.

J Crit Care 2018 Nov 30;50:144-154. Epub 2018 Nov 30.

Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:

Purpose: Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults.

Materials And Methods: The primary research question was: "Are crystalloids sufficient for volume replacement in severe indications (intensive care unit [ICU]/critical illness)?" Randomized, controlled trials (RCTs) were identified using PubMed and EMBASE, and screened against predefined inclusion/exclusion criteria. Read More

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November 2018

Additional Effect of Perioperative, Compared with Preoperative, Immunonutrition After Pancreaticoduodenectomy: A Randomized, Controlled Trial.

Int J Surg 2018 Dec 9. Epub 2018 Dec 9.

From the Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-0856, Japan.

Background: We have reported that perioperative and preoperative immunonutrition reduced infectious complications in patients undergoing pancreaticoduodenectomy; however, it is unclear whether perioperative immunonutrition has additional effects compared with preoperative immunonutrition. The present study evaluated whether perioperative, compared with preoperative, immunonutrition has additional effects on cell-mediated immunity and the infection rate after pancreaticoduodenectomy.

Materials And Methods: This was a prospective, randomized clinical trial conducted in our institution. Read More

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December 2018

Surgical outcomes of renal transplant recipients after abdominal surgery not connected with transplantation A retrospective case-control study.

Int J Surg 2018 Dec 9. Epub 2018 Dec 9.

Department for General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Background: Due to the increasing number of patients after kidney transplantation, elective and emergency surgery of transplanted patients is becoming a relevant challenge in clinical routine. The current data on complication rate of patients after kidney transplantation, which must undergo another elective or emergency abdominal surgery, is inhomogeneous. Therefore, the aim of our study was to evaluate the outcome of renal transplant patients undergoing abdominal and abdominal wall surgery. Read More

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December 2018

Condition-Dependent Neural Dimensions Progressively Shift during Reach to Grasp.

Cell Rep 2018 Dec;25(11):3158-3168.e3

Department of Neuroscience, University of Rochester, Rochester, NY 14642, USA; Department of Neurology, University of Rochester, Rochester, NY 14642, USA; Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA; Del Monte Institute for Neuroscience, University of Rochester, Rochester, NY 14642, USA. Electronic address:

Neural population space analysis was performed to assess the dimensionality and dynamics of the neural population in the primary motor cortex (M1) during a reach-grasp-manipulation task in which both the reach location and the object being grasped were varied. We partitioned neural activity into three components: (1) general task-related activity independent of location and object, (2) location- and/or object-related activity, and (3) noise. Neural modulation related to location and/or object was only one-third the size of either general task modulation or noise. Read More

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December 2018

IGFBP7 Induces Differentiation and Loss of Survival of Human Acute Myeloid Leukemia Stem Cells without Affecting Normal Hematopoiesis.

Cell Rep 2018 Dec;25(11):3021-3035.e5

Department of Hematology, Cancer Center Amsterdam (CCA), Amsterdam UMC, VU Medical Center, Amsterdam, the Netherlands. Electronic address:

Leukemic stem cells (LSCs) are thought to be the major cause of the recurrence of acute myeloid leukemia (AML) due to their potential for self-renewal. To identify therapeutic strategies targeting LSCs, while sparing healthy hematopoietic stem cells (HSCs), we performed gene expression profiling of LSCs, HSCs, and leukemic progenitors all residing within the same AML bone marrow and identified insulin-like growth factor-binding protein 7 (IGFBP7) as differentially expressed. Low IGFBP7 is a feature of LSCs and is associated with reduced chemotherapy sensitivity. Read More

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December 2018
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Novel therapeutic approaches in primary hyperoxaluria.

Expert Opin Emerg Drugs 2018 Dec 12:1-9. Epub 2018 Dec 12.

a Division of Pediatric Nephrology , University Childrens Hospital, Universitatsklinikum Bonn , Bonn , Germany.

Introduction: Currently, three types of primary hyperoxaluria (PH I-III) are known, all based on different gene-mutations affecting the glyoxylate metabolism in the liver. Disease hallmark is an increased endogenous oxalate production and thus massively elevated urinary excretion of oxalate and other type-specific metabolites. Hyperoxaluria induces the formation of calcium-oxalate kidney stones and/or nephrocalcinosis. Read More

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December 2018

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

FASEB J 2018 Dec 12:fj201802015R. Epub 2018 Dec 12.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Levels of augmenter of liver regeneration (ALR), a multifunctional protein, are reduced in steatohepatitis. ALR depletion from ALR /Alb-Cre [ALR-L-knockout (KO)] mouse causes robust steatosis and apoptosis of hepatocytes, and pericellular fibrosis between 1 and 2 wk postbirth. Steatosis regresses by 4 wk upon reappearance of ALR-expressing hepatocytes. Read More

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December 2018

[Survival of pediatric patients with Ewing sarcoma treated at Semmelweis University].

Magy Onkol 2018 Dec 19;62(4):230-236. Epub 2018 Oct 19.

II. Sz. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Budapest, Hungary.

The survival of children treated with Ewing sarcoma at Semmelweis University were investigated. Pediatric patients with Ewing sarcoma treated at Semmelweis University from 2001 through 2013 were analyzed in terms of overall survival and clinical factors (age, primary localization and extent of the tumor, time interval from primary complaints to diagnosis). For statistical analysis Kaplan-Meier estimated survival and log rank test were applied. Read More

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December 2018

The know-do gap in sick child care in Ethiopia.

PLoS One 2018 12;13(12):e0208898. Epub 2018 Dec 12.

International Institue for Primary Health Care- Ethiopia, Addis Ababa, Ethiopia.

Background: While health care provider knowledge is a commonly used measure for process quality of care, evidence demonstrates that providers don't always perform as much as they know. We describe this know-do gap for malaria care for sick children among providers in Ethiopia and examine what may predict this gap.

Methods: We use a 2014 nationally-representative survey of Ethiopian providers that includes clinical knowledge vignettes of malaria care and observations of care provided to children in facilities. Read More

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December 2018

Changes of sexual risk behaviors and sexual connections among HIV-positive men who have sex with men along their HIV care continuum.

PLoS One 2018 12;13(12):e0209008. Epub 2018 Dec 12.

Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong.

Background: While HIV incidence among men who have sex with men (MSM) is increasing in Hong Kong, unprotected sex apparently remains prevalent among those infected but virally non-suppressed. Little is known about how sexual behaviours and sexual connections may change among MSM along their HIV care continuum.

Methods: In this retrospective cross-sectional study, HIV-positive MSM attending the largest HIV specialist clinic in Hong Kong between October and December 2014 were invited to complete a self-administrated structured questionnaire. Read More

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December 2018

Development and implementation of a pediatric adverse childhood experiences (ACEs) and other determinants of health questionnaire in the pediatric medical home: A pilot study.

PLoS One 2018 12;13(12):e0208088. Epub 2018 Dec 12.

The Center for Youth Wellness, San Francisco, California, United States of America.

Adverse Childhood Experiences (ACEs) are associated with poor health outcomes, underlining the significance of early identification and intervention. Currently, there is no validated tool to screen for ACEs exposure in childhood. To fill this gap, we designed and implemented a pediatric ACEs questionnaire in an urban pediatric Primary Care Clinic. Read More

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December 2018

Different clinical features according to the anastomotic leakage subtypes after rectal cancer surgeries: contained vs. free leakages.

PLoS One 2018 12;13(12):e0208572. Epub 2018 Dec 12.

Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Background: Anastomotic leakage can be classified by free and contained leakage according to clinical manifestations. The risk factors and their comparison between these leakage subtypes are uncertain. This study aims to evaluate anastomotic leakage patterns and to compare clinical features between free and contained leakages after low anterior resection for rectal cancer. Read More

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December 2018
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First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children.

PLoS One 2018 12;13(12):e0208328. Epub 2018 Dec 12.

Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso.

Background: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20-25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.

Methodology: We conducted the first Phase IIb clinical trial assessing the safety, immunogenicity and efficacy of ChAd63 MVA ME-TRAP in 700 healthy malaria exposed children aged 5-17 months in a highly endemic malaria transmission area of Burkina Faso. Read More

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December 2018

Computerization and the future of primary care: A survey of general practitioners in the UK.

PLoS One 2018 12;13(12):e0207418. Epub 2018 Dec 12.

General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, United States of America.

Objective: To describe the opinions of British general practitioners regarding the potential of future technology to replace key tasks carried out in primary care.

Design: Cross sectional online survey.

Participants: 1,474 registered GPs in the United Kingdom. Read More

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December 2018
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Use of RFID technology to characterize feeder visitations and contact network of hummingbirds in urban habitats.

PLoS One 2018 12;13(12):e0208057. Epub 2018 Dec 12.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America.

Despite the popular use of hummingbird feeders, there are limited studies evaluating the effects of congregation, sharing food resources and increased contact when hummingbirds visit feeders in urban landscapes. To evaluate behavioral interactions occurring at feeders, we tagged 230 individuals of two species, Anna's and Allen's Hummingbirds, with passive integrated transponder tags and recorded their visits with RFID transceivers at feeders. For detecting the presence of tagged birds, we developed an RFID equipped feeding station using a commercially available antenna and RFID transceiver. Read More

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December 2018

Systemic involvement in ACS: Using CMR imaging to compare the aortic wall in patients with and without acute coronary syndrome.

PLoS One 2018 12;13(12):e0203514. Epub 2018 Dec 12.

Division of Cardiology, Institute for Cardiology and Cardiac Surgery, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States of America.

Background/objectives: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta.

Methods: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up. Read More

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December 2018

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

PLoS Negl Trop Dis 2018 Dec 12;12(12):e0006977. Epub 2018 Dec 12.

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia Pennsylvania, United States of America.

Background: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection. Small animal models that support the development of adult parasites have not been identified.

Methodology/principal Findings: We hypothesized that highly immunodeficient NSG mice would support the survival and maturation of O. Read More

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December 2018
1 Read

[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
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Pre-operative Assessment of Bone Quality in Spine Deformity Surgery: Correlation with Clinical Practice and Published Recommendations.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, NYU Langone Health, New York, NY.

Study Design: Retrospective cohort study.

Objective: The goals of this study were to (1) evaluate pre-operative bone quality assessment and intervention practice over time and (2) review the current evidence for bone evaluation in spine fusion surgery.

Summary Of Background Data: Deformity spine surgery has demonstrated improved quality of life in patients however its cost has made it controversial. Read More

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December 2018

Intravenous and Oral Tranexamic Acid are Equivalent at Reducing Blood Loss in Thoracolumbar Spinal Fusion: A Prospective Randomized Trial.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, Henry Ford Health System, Detroit, MI 48202.

Study Design: A prospective randomized trial of patients enrolled at a university affiliated tertiary medical center between February and December 2017.

Objective: To compare perioperative blood loss in patients undergoing elective posterior thoracolumbar fusion who were treated with IV versus PO TXA.

Summary Of Background Data: The use of antifibrinolytic agents such as tranexamic acid (TXA) to decrease operative blood loss and allogenic blood transfusions is well documented in the literature. Read More

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December 2018

Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis.

Otol Neurotol 2019 Jan;40(1):e32-e39

Department of Otorhinolaryngology.

Objectives: Patients with otosclerosis more often complain about postoperative taste disturbance than patients with chronic otitis media, which seems paradoxical. We aim to investigate if and potentially why this seems to be the case, since the chorda tympani nerve (CTN) is thought to be severely traumatized less frequently during surgery in the former than in the latter.

Study Design: Prospective cohort study. Read More

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January 2019

Assessing the Value of Endoscopy Simulator Modules Designed to Prepare Residents for the Fundamentals of Endoscopic Surgery Examination.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: The Fundamentals of Endoscopic Surgery examination is required for all general surgery residents. The test modules are not available for practice before the examination; however, similar modules are commercially available.

Objective: This study aims to determine which modules are most valuable for resident training and preparation for the examination by evaluating which correlates best with experience level. Read More

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November 2018

Abnormal Pouchogram Predicts Pouch Failure Even in Asymptomatic Patients.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: Anastomotic complications after restorative total proctocolectomy with IPAA for ulcerative colitis alter functional outcomes and quality of life and may lead to pouch failure. Routine contrast enema of the pouch assesses anastomotic integrity before ileostomy reversal, but its clinical use is challenged.

Objective: The purpose of this research was to assess the relationship among preoperative clinical characteristics, abnormal pouchography, and long-term pouch complications. Read More

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November 2018

Methodologic Validation of a Faster Pelvic Floor Test: Two Randomized Studies in Anal Acoustic Reflectometry.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: Anal acoustic reflectometry investigates the opening and closing function of the anal canal using reflected sound waves to measure a cross-sectional area at different pressures. Anal acoustic reflectometry is reliable and repeatable, distinguishes between continence and incontinence and between subgroups of incontinence, correlates with symptom severity, and does not distort the anal canal during investigation.

Objective: The purpose of this study was to validate anal acoustic reflectometry methodology by asking 2 questions: can anal acoustic reflectometry be used alongside manometry (order study) and can anal acoustic reflectometry be performed faster (filling study). Read More

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November 2018

A Quartet of Elastic Stable Intramedullary Nails for More Challenging Pediatric Femur Fractures.

J Pediatr Orthop 2019 Jan;39(1):e12-e17

Children's Healthcare of Atlanta.

Introduction: The insertion of 2 elastic stable intramedullary nails (ESINs) is a common treatment for pediatric femur fractures. However, the use of this technique in length-unstable or metadiaphyseal fractures has historically been associated with higher complication rates. To improve stability, the addition of a third ESIN has been assessed biomechanically and clinically, but the addition of a fourth nail has only been evaluated biomechanically. Read More

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January 2019

Design and rationale of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Institute of Cardiovascular Sciences, University of Birmingham, SWBH and UHB NHS Trusts, Birmingham, UK.

Aim: Edoxaban, a nonvitamin K antagonist oral anticoagulant, is an oral factor Xa inhibitor approved for the prevention of stroke and systemic embolism in adult patients with atrial fibrillation and for the treatment and secondary prevention in adult patients with venous thromboembolism (VTE). This study details the design of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study - a postauthorization observational study, which is part of the postapproval plan for edoxaban agreed with the European Medicines Agency.

Methods: The ETNA-AF-Europe study (Clinicaltrials. Read More

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December 2018
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Comparison of rocuronium requirement in children with continuous infusion versus intermittent bolus: A randomised controlled trial.

Eur J Anaesthesiol 2018 Dec 11. Epub 2018 Dec 11.

From the Department of Anaesthesiology and Pain Medicine, Seoul National University Hospital (S-N C, Y-E J, J-H L, E-H K, J-T K, H-S K), Department of Anaesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea (H-S K).

Background: Minimising rocuronium administration during paediatric surgery helps to reduce the incidence of residual muscular blockade.

Objective: To determine whether intermittent bolus injection (Bolus group) or continuous infusion (group) requires the lesser amount of rocuronium.

Design: A prospective, randomised, single-blind controlled trial. Read More

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December 2018
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