391,162 results match your criteria Primary Care & Community Psychiatry[Journal]


Effect of Prophylactic Amiodarone Infusion on the Recurrence of Ventricular Arrhythmias in Out-of-Hospital Cardiac Arrest Survivors: A Propensity-Matched Analysis.

J Clin Med 2019 Feb 13;8(2). Epub 2019 Feb 13.

Department of Emergency Medicine, Ulsan University College of Medicine, Asan Medical Center, Seoul 05505, Korea.

Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the effectiveness of prophylactic amiodarone in preventing ventricular arrhythmia recurrence in OHCA survivors. Data of consecutive adult non-traumatic OHCA survivors treated with TTM between 2010 and 2016 were extracted from prospective cardiac arrest registries of four tertiary care hospitals. Read More

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http://dx.doi.org/10.3390/jcm8020244DOI Listing
February 2019

Bridging the Gap between Theory and Practice; the Active Role of Inpatient Pharmacists in Therapeutic Drug Monitoring.

Pharmacy (Basel) 2019 Feb 18;7(1). Epub 2019 Feb 18.

King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, 21423 Jeddah, Saudi Arabia.

Many hospitals face barriers in the implementation of TDM services, this study aimed to evaluate a pharmacist-led TDM service to optimize patients' outcomes. Adult patients who were administered vancomycin, gentamicin, or amikacin were included. The pre-phase included a retrospective assessment of patients and the intervention phase consisted of an educational program. Read More

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http://dx.doi.org/10.3390/pharmacy7010020DOI Listing
February 2019

The Obemat2.0 Study: A Clinical Trial of a Motivational Intervention for Childhood Obesity Treatment.

Nutrients 2019 Feb 16;11(2). Epub 2019 Feb 16.

Pediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, IISPV, 43201 Reus, Spain.

The primary aim of the Obemat2.0 trial was to evaluate the efficacy of a multicomponent motivational program for the treatment of childhood obesity, coordinated between primary care and hospital specialized services, compared to the usual intervention performed in primary care. This was a cluster randomized clinical trial conducted in Spain, with two intervention arms: motivational intervention group vs. Read More

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http://dx.doi.org/10.3390/nu11020419DOI Listing
February 2019

Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications.

Am J Perinatol 2019 Feb 19. Epub 2019 Feb 19.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  Adding azithromycin to standard antibiotic prophylaxis for unscheduled cesarean delivery has been shown to reduce postcesarean infections. Because wound infection with ureaplasmas may not be overtly purulent, we assessed the hypothesis that azithromycin-based extended-spectrum antibiotic prophylaxis also reduces wound complications that are identified as noninfectious.

Study Design:  This is a secondary analysis of the C/SOAP (Cesarean Section Optimal Antibiotic Prophylaxis) randomized controlled trial, which enrolled women with singleton pregnancies ≥24 weeks who were undergoing nonelective cesarean. Read More

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http://dx.doi.org/10.1055/s-0039-1679914DOI Listing
February 2019

The influence of attachment style and relationship quality on quality of life and psychological distress in carers of people with epileptic and nonepileptic seizures.

Epilepsy Behav 2019 Feb 16;93:16-21. Epub 2019 Feb 16.

Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom; Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.

Background: Seizure disorders affect not only the individual living with seizures, but also those caring for them. Carer-patient relationships may be influenced by, and have an influence on, some aspects of living with seizure disorders - with potentially different interactions seen in epilepsy and psychogenic nonepileptic seizures (PNES).

Objectives: We studied the influence of patient and carer attachment style and relationship quality on carer wellbeing and psychological distress, and explored whether these associations differ between carers for people with epilepsy and for those with PNES. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.028DOI Listing
February 2019

Does care at a cardiac arrest centre improve outcome after out-of-hospital cardiac arrest? - A systematic review.

Resuscitation 2019 Feb 16. Epub 2019 Feb 16.

Department of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Finland.

Aim: To perform a systematic review to answer 'In adults with attempted resuscitation after non-traumatic cardiac arrest does care at a specialised cardiac arrest centre (CAC) compared to care in a healthcare facility not designated as a specialised cardiac arrest centre improve patient outcomes?'

Methods: The PRISMA guidelines were followed. We searched bibliographic databases (Embase, MEDLINE and the Cochrane Library (CENTRAL)) from inception to 1 August 2018. Randomised controlled trials (RCTs) and non-randomised studies were eligible for inclusion. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.006DOI Listing
February 2019

Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease: Rationale, design, and implementation of a pragmatic comparative effectiveness trial.

Contemp Clin Trials 2019 Feb 16. Epub 2019 Feb 16.

Division of Neurology, University of Alberta, 11350-83 Avenue, 7-112 Clinical Sciences Building, Edmonton, AB T6G 2G3, Canada. Electronic address:

Patients with Parkinson's disease and related disorders (PDRD) and their families have considerable unmet needs including non-motor symptom management, caregiver support, spiritual wellbeing, advance care planning, and end-of-life care. There is increasing interest in applying palliative care (PC) models to better meet these needs. While PC has been shown to improve care and quality of life (QOL) for people with cancer and heart failure, few studies have evaluated the role of PC for people with PDRD. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.005DOI Listing
February 2019

A highly structured decision-making process results in GRADE factors having primary influence on how guidelines panels develop clinical recommendations.

J Clin Epidemiol 2019 Feb 16. Epub 2019 Feb 16.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Background: The determinants of practice guideline panels' recommendations remain uncertain.

Objective: To investigate factors considered by members of 8 panels convened by the American Society of Hematology to develop guidelines when using the GRADE system.

Methods: Two level hierarchical, random-effect, multivariable logistic regression analysis to explore the relation between GRADE and non-GRADE factors and strength of recommendations (SOR). Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.009DOI Listing
February 2019

The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner.

PLoS One 2019 19;14(2):e0212321. Epub 2019 Feb 19.

Department of Physiology, School of Medicine, Universidad Austral de Chile, Valdivia, Chile.

Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown. Nevertheless, clinicopathological data shows that in more than a dozen kinds of cancer, including gliomas, GOLPH3 could be found overexpressed, which correlates with poor prognosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212321PLOS
February 2019

Clinical indicators of adrenal insufficiency following discontinuation of oral glucocorticoid therapy: A Danish population-based self-controlled case series analysis.

PLoS One 2019 19;14(2):e0212259. Epub 2019 Feb 19.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Biochemical adrenal insufficiency induced by glucocorticoid treatment is prevalent, but data on the clinical implications are sparse. We investigated clinical consequences of glucocorticoid-induced adrenal insufficiency after oral glucocorticoid cessation.

Methods: We conducted a Danish population-based self-controlled case series utilizing medical registries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212259PLOS
February 2019

Associations of anxiety with discomfort and tolerance in Chinese patients undergoing esophagogastroduodenoscopy.

PLoS One 2019 19;14(2):e0212180. Epub 2019 Feb 19.

Scientific Research Centre, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Objectives: To evaluate the associations of pre-endoscopy anxiety with discomfort and tolerance in patients undergoing unsedated esophagogastroduodenoscopy (EGD).

Methods: This is a hospital-based cohort study of 348 patients undergoing routine, non-advanced EGD without sedation. The primary outcomes were discomfort and tolerance. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212180PLOS
February 2019

Hemodynamic-Directed Cardiopulmonary Resuscitation Improves Neurologic Outcomes and Mitochondrial Function in the Heart and Brain.

Crit Care Med 2019 Mar;47(3):e241-e249

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objectives: Less than half of the thousands of children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival and mitochondrial respiration-a potential neurotherapeutic target-remains unknown. The primary objectives of this study were to compare rates of 24-hour survival with favorable neurologic outcome after cardiac arrest treated with hemodynamic-directed cardiopulmonary resuscitation versus standard depth-guided cardiopulmonary resuscitation and to compare brain and heart mitochondrial respiration between groups 24 hours after resuscitation. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003620DOI Listing

Should Human Rights and Autonomy be The Primary Determinants for the Disclosure of a Decision to Withhold Futile Resuscitation?

Authors:
Sarah Cahill

New Bioeth 2019 Mar;25(1):39-59

a Institute of Theology , St Mary's University , Twickenham, London , UK.

Do not attempt cardiopulmonary resuscitation decisions (DNACPR) are considered good medical practice for those dying at the end of natural life. They avoid intrusive and inappropriate intervention. Historically, informing patients of these decisions was discretionary to avoid undue distress. Read More

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http://dx.doi.org/10.1080/20502877.2019.1574133DOI Listing

Adoption of a Closed-Loop Communication Tool to Establish and Execute a Collaborative Follow-Up Plan for Incidental Pulmonary Nodules.

AJR Am J Roentgenol 2019 Feb 19:1-5. Epub 2019 Feb 19.

1 Department of Radiology, Center for Evidence-Based Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.

Objective: The purpose of this study is to assess radiologists' adoption of a closed-loop communication and tracking system, Result Alert and Development of Automated Resolution (RADAR), for incidental pulmonary nodules and to measure its effect on the completeness of radiologists' follow-up recommendations.

Materials And Methods: This retrospective study was performed at a tertiary academic center that performs more than 600,000 radiology examinations annually. Before RADAR, the institution's standard of care was for radiologists to generate alerts for newly discovered incidental pulmonary nodules using a previously described PACS-embedded software tool. Read More

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http://dx.doi.org/10.2214/AJR.18.20692DOI Listing
February 2019

Isolated Right-Sided Varicocele: Is Further Workup Necessary?

AJR Am J Roentgenol 2019 Feb 19:1-6. Epub 2019 Feb 19.

1 Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, E6-230, Dallas, TX 75390-9316.

Objective: Unilateral left varicoceles are common and considered benign. Unilateral right varicoceles are reportedly associated with a pathologic process, namely malignancy affecting the retroperitoneum, for which further imaging is often recommended. The purpose of this study was to test the hypothesis that this correlation between unilateral right varicocele and malignancy may be weaker than once suggested, particularly in the absence of other clinical signs of malignancy. Read More

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http://dx.doi.org/10.2214/AJR.18.20077DOI Listing
February 2019

Sex Differences in the Prevalence of, and Trends in, Cardiovascular Risk Factors, Treatment, and Control in the United States, 2001 to 2016.

Circulation 2019 Feb;139(8):1025-1035

The George Institute for Global Health, University of Oxford, Oxford, UK (S.A.E.P., M.W.).

Background: Improvements have been made in the treatment and control of some but not all major cardiovascular risk factors in the United States. It remains unclear whether women and men have benefited equally.

Methods: Data from the 2001 to 2002 through the 2015 to 2016 US National Health and Nutrition Examination Survey on adults aged 20 to 79 years were used. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035550DOI Listing
February 2019

IL-6 released from muscles during exercise is stimulated by lactate-dependent protease activity.

Am J Physiol Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

The Centre of Inflammation and Metabolism (CIM) and the Centre for Physical Activity Research (CFAS), Copenhagen University Hospital, 7641, University of Copenhagen, Denmark.

Background: IL-6 is secreted from muscles to the circulation during high intensity and long duration exercise, where muscle-derived IL-6 works as an energy sensor to increase release of energy substrates from liver and adipose tissues. Here, we investigated the mechanism involved in the exercise-mediated surge in IL-6 during exercise.

Methods: Using interval-based cycling in healthy young men, swimming exercise in mice and electrical stimulation of primary human muscle cells, we explored the role of lactate production in muscular IL-6 release during exercise. Read More

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http://dx.doi.org/10.1152/ajpendo.00414.2018DOI Listing
February 2019

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.

N Engl J Med 2019 02 16. Epub 2019 Feb 16.

From Memorial Sloan Kettering Cancer Center (R.J.M.) and Pfizer (S.H.), New York; Private Medical Institution Euromedservice (K.P.) and Nonstate Health Institution Road Clinical Hospital-Russian Railways (A.V.), St. Petersburg, and the Moscow Scientific Research Oncology Institute, Moscow (B.A.) - all in Russia; the Netherlands Cancer Institute, Amsterdam (J.H.); the Cleveland Clinic, Cleveland (B.R.); Institut Gustave Roussy, Villejuif (L.A.), and Centre Léon Bérard, University of Lyon, Lyon (S.N.) - both in France; the University of Texas M.D. Anderson Cancer Center, Houston (M.T.C.); University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow (B.V.), and Royal Marsden NHS Foundation Trust, London (J.L.) - both in the United Kingdom; British Columbia Cancer Agency, Vancouver (C.K.), and Lady Davis Institute and Jewish General Hospital, McGill University, Montreal (W.H.M.) - both in Canada; Osaka University Hospital, Osaka, Japan (M.U.); University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (J.L.L.); Macquarie University, Sydney (H.G.); Department of Medicine I, Clinical Division of Oncology and Comprehensive Cancer Center, Medical University of Vienna, Vienna (M.S.); Georgetown Lombardi Comprehensive Cancer Center, Washington, DC (M.B.A.); Department of Urology, University of Tübingen, Tübingen, Germany (J.B.); Pfizer, Cambridge (J.W., A.C.), and the Lank Center for Genitourinary Oncology at Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston (T.K.C.) - both in Massachusetts; Pfizer (M.M., A.P.) and Pfizer Italia (C.F.), Milan; Pfizer, San Diego, CA (P.B.R.); and Pfizer, Groton, CT (B.H.).

Background: In a single-group, phase 1b trial, avelumab plus axitinib resulted in objective responses in patients with advanced renal-cell carcinoma. This phase 3 trial involving previously untreated patients with advanced renal-cell carcinoma compared avelumab plus axitinib with the standard-of-care sunitinib.

Methods: We randomly assigned patients in a 1:1 ratio to receive avelumab (10 mg per kilogram of body weight) intravenously every 2 weeks plus axitinib (5 mg) orally twice daily or sunitinib (50 mg) orally once daily for 4 weeks (6-week cycle). Read More

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http://dx.doi.org/10.1056/NEJMoa1816047DOI Listing
February 2019

Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis.

N Engl J Med 2019 02 18. Epub 2019 Feb 18.

From the College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (Y.M.A., S.J.A., S.A.I.A., A.A.-D.), the Departments of Intensive Care (Y.M.A., S.J.A., S.A.I.A., A.A.-D.) and Emergency Medicine, (S.J.A.), Ministry of National Guard Health Affairs, Military Medical Services, Ministry of Defense (Y. Mandourah), the Department of Intensive Care Services, Prince Sultan Military Medical City (G.A.A.), the Department of Pulmonary and Critical Care Medicine, King Fahad Medical City (M.A., H.L.), Critical Care Medicine Department, King Faisal Specialist Hospital and Research Center (H.H.), and the Department of Biostatistics and Bioinformatics (J.J.) and Research Office (L.Y.A.), King Abdullah International Medical Research Center (Y.M.A., S.J.A., S.A.I.A., A.A.-D.), Riyadh, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, and the Intensive Care Department, Ministry of National Guard Health Affairs (F.A.-H.), and Critical Care Section, Department of Medicine, King Faisal Specialist Hospital and Research Center (I.K.), Jeddah, the Department of Emergency and Critical Care Medicine, College of Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University (M.S.A.), Dammam, the Department of Critical Care Medicine, King Khalid University, Asir Central Hospital (A.A.B.), Abha, and King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, and the Intensive Care Division, Department of Medicine, King Abdulaziz Hospital (A.A.A.), Al Ahsa - all in Saudi Arabia; St. Michael's Hospital, Li Ka Shing Knowledge Institute (K.E.A.B.), the Department of Medicine, Sinai Health System (S.M.), and Interdepartmental Division of Critical Care Medicine, University of Toronto (K.E.A.B, S. M.) - all in Toronto; the George Institute for Global Health (S.F.), the Department of Intensive Care Medicine, Centre for Applied Medical Research, St. Vincent's Hospital (H.B.), and the University of New South Wales, Sydney (S.F., H.B.), and Intensive Care Department, Gosford Hospital, Gosford, NSW (A.G.) - all in Australia; and the Department of Anesthesiology and Critical Care, King George's Medical University, Lucknow (Z.A.), and Institute of Critical Care and Anesthesiology, Medanta-The Medicity, Gurgaon (Y. Mehta) - both in India.

Background: Whether adjunctive intermittent pneumatic compression in critically ill patients receiving pharmacologic thromboprophylaxis would result in a lower incidence of deep-vein thrombosis than pharmacologic thromboprophylaxis alone is uncertain.

Methods: We randomly assigned patients who were considered adults according to the local standards at the participating sites (≥14, ≥16, or ≥18 years of age) within 48 hours after admission to an intensive care unit (ICU) to receive either intermittent pneumatic compression for at least 18 hours each day in addition to pharmacologic thromboprophylaxis with unfractionated or low-molecular-weight heparin (pneumatic compression group) or pharmacologic thromboprophylaxis alone (control group). The primary outcome was incident (i. Read More

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http://dx.doi.org/10.1056/NEJMoa1816150DOI Listing
February 2019

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults.

N Engl J Med 2019 02 18. Epub 2019 Feb 18.

From the Division of Allergy, Pulmonary, and Critical Care Medicine (J.D.C., R.M.B., B.E.H., M.G.L., A.H.T., T.W.R., M.W.S.), and the Department of Emergency Medicine (W.H.S.), Vanderbilt University Medical Center, Nashville; the Section of Pulmonary, Critical Care, and Allergy and Immunology (D.R.J.), and the Section of Emergency Medicine (D.J.V.), Louisiana State University School of Medicine-New Orleans, and the Department of Pulmonary and Critical Care Medicine, Ochsner Health System (D.J.V., K.M.D.) - both in New Orleans; the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham (D.W.R., A.N.Z., S.G.); and the Department of Anesthesiology and Pain Medicine (A.M.J.) and the Division of Pulmonary and Critical Care (I.B.), University of Washington School of Medicine, Seattle.

Background: Hypoxemia is the most common complication during tracheal intubation of critically ill adults and may increase the risk of cardiac arrest and death. Whether positive-pressure ventilation with a bag-mask device (bag-mask ventilation) during tracheal intubation of critically ill adults prevents hypoxemia without increasing the risk of aspiration remains controversial.

Methods: In a multicenter, randomized trial conducted in seven intensive care units in the United States, we randomly assigned adults undergoing tracheal intubation to receive either ventilation with a bag-mask device or no ventilation between induction and laryngoscopy. Read More

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http://dx.doi.org/10.1056/NEJMoa1812405DOI Listing
February 2019

Prevalence of Portable Point of Care Tests Used on Medical Service Trips in Latin America and the Caribbean.

Ann Glob Health 2018 Nov 5;84(4):736-742. Epub 2018 Nov 5.

Toronto Rehabilitation Institute, University Health Network, CA.

Background: Short-term, primary care medical service trips (MSTs) frequently use inexpensive, portable point of care (POC) tests to guide diagnosis and treatment of patients in low-resource settings. However, the degree to which different POC tests are carried by organizations serving remote communities is currently unknown.

Objective: The aim of this study was to determine the prevalence of various POC tests used by MST-sending organizations operating in Latin America. Read More

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http://dx.doi.org/10.9204/aogh.2385DOI Listing
November 2018

Predictors of Health Care Service Quality among Women Insured Under Ghana's National Health Insurance Scheme.

Ann Glob Health 2018 Nov 5;84(4):640-649. Epub 2018 Nov 5.

Department of Population Family and Reproductive Health, School of Public Health, College of Health Sciences, University of Ghana, GH.

Background: Insured women in Ghana are more likely to use maternity care services than their uninsured counterparts. To improve service quality among insured women in Ghana, better understanding of the factors that predict quality standards of primary health care services is essential.

Objective: To examine predictors of health care service quality among insured women under the National Health Insurance Scheme (NHIS) in Ghana. Read More

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http://dx.doi.org/10.9204/aogh.2371DOI Listing
November 2018

A Review of Hypertension and Diabetes Protocols for Medical Service Trips (MSTs) in Latin America and the Caribbean.

Ann Glob Health 2018 Nov 5;84(4):563-570. Epub 2018 Nov 5.

Toronto Rehabilitation Institute, University Health Network, CA.

Background: Hypertension and diabetes are among the most common chronic conditions that may be managed on short-term, primary care medical service trips (MSTs) in Latin America and the Caribbean (LAC), but the quality of patient care delivered remains unclear.

Objective: This study summarizes protocols that Western volunteer clinicians use in managing these patients, and highlights their commonalities, differences, and potential limitations.

Methods: A systematic web search was used to identify organizations operating MSTs in LAC. Read More

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http://dx.doi.org/10.9204/aogh.2387DOI Listing
November 2018

Low rates of dental attendance by the age of one and inequality between local government administrative areas in England.

Community Dent Health 2019 Feb 19. Epub 2019 Feb 19.

School of Dentistry, University of Birmingham, 5 Mill Pool Way, Birmingham B5 7EG.

Objective: To describe child dental attendance (DA) by 1 year of age in England and its relationship with area deprivation.

Basic Research Design: Analysis of National Health Service data for the 12 months to June 2017. Deprivation was measured by Index of Multiple Deprivation Rank of Average Score (2015) for upper-tier and unitary local authorities in England (LAs, n=151). Read More

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http://dx.doi.org/10.1922/CDH_4390Salomon-Ibarra05DOI Listing
February 2019

Functional mobility trajectories of hospitalized older adults admitted to acute geriatric wards: A retrospective observational study in an English university hospital.

Geriatr Gerontol Int 2019 Feb 18. Epub 2019 Feb 18.

Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Aim: The mobility trajectories of hospitalized older people are heterogeneous, and there is a need to understand patient groups with similar trajectories. Our aims were to identify mobility trajectories of older patients admitted to geriatric wards in an English university hospital, and describe patient characteristics and outcomes associated with different mobility groups.

Methods: A retrospective observational study of first admissions to geriatric wards for 3 months starting 1 May 2016 was carried out. Read More

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http://dx.doi.org/10.1111/ggi.13623DOI Listing
February 2019

Augmented renal clearance: a common condition in critically ill children.

Pediatr Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium.

Background: Augmented renal clearance (ARC), an increase in kidney function with enhanced elimination of circulating solute, has been increasingly recognized in critically ill adults. In a pediatric intensive care setting, data are scarce. The primary objective of this study was to investigate the prevalence of ARC in critically ill children. Read More

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http://dx.doi.org/10.1007/s00467-019-04205-xDOI Listing
February 2019

Hospitalization rate in offspring of cancer survivors: a national cohort study.

J Cancer Surviv 2019 Feb 18. Epub 2019 Feb 18.

Center for Primary Health Care Research, Lund University/Region Skåne, Malmö University Hospital, CRC, floor 11, building 28, entrance 72, 205 02, Malmö, Sweden.

Purpose: The number of childbirths among cancer survivors continues to increase, but it is still largely unknown whether the children of cancer survivors might experience adverse health outcomes during the process of growing up.

Methods: We identified all individuals diagnosed with cancer between 1958 and 2015 from the Swedish Cancer Registry and linked them to the Swedish Medical Birth Register to identify their offspring born between 1997 and 2015. Up to 10 children, whose parents did not have a diagnosis of cancer, were matched with the study population according to date of birth and gender. Read More

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http://dx.doi.org/10.1007/s11764-019-00741-5DOI Listing
February 2019

Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide for Primary Immune Deficiency Disorders in Children: Challenges and Outcome from a Tertiary Care Center in South India.

J Clin Immunol 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatric Hematology, Oncology, Blood and Marrow Transplantation, Apollo Hospitals, 320, Padma complex, Anna salai, Teynampet, Chennai, Tamil Nadu, 600035, India.

Haploidentical stem cell transplantation (haplo SCT) has emerged as an acceptable alternative to matched family donor transplantation for children diagnosed to have primary immune deficiency disorders (PIDs). We present data over 4 years on the challenges and efficacy of unmanipulated T cell replete haplo SCTs with post-transplant cyclophosphamide (PTCy) in children diagnosed to have PIDs. We performed a retrospective study in the pediatric blood and marrow transplantation unit where all children less than 18 years of age diagnosed to have PIDs and who underwent haplo SCT with PTCy from January 2014 to February 2018 were included in the study. Read More

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http://dx.doi.org/10.1007/s10875-019-00600-zDOI Listing
February 2019

Two-Year Follow-Up of a Multi-centre Randomized Controlled Trial to Study Effectiveness of a Hospital-Based Work Support Intervention for Cancer Patients.

J Occup Rehabil 2019 Feb 16. Epub 2019 Feb 16.

Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Purpose Purpose is to: (1) study effectiveness of the hospital-based work support intervention for cancer patients at two years of follow-up compared to usual care and (2) identify which early factors predict time to return-to-work (RTW). Methods In this multi-center randomised controlled trial (RCT), 106 (self-)employed cancer patients were randomized to an intervention group or control group and provided 2 years of follow-up data. The intervention group received patient education and work-related support at the hospital. Read More

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http://dx.doi.org/10.1007/s10926-019-09831-8DOI Listing
February 2019

Coeliac disease detection with an IgA/IgG-deamidated gliadin peptide based point of care test in community pharmacies.

Int J Clin Pharm 2019 Feb 16. Epub 2019 Feb 16.

Academic Department of Gastroenterology, Room P18, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, S10 2JF, UK.

Background Coeliac disease affects 1% of the population, but 75% remain undiagnosed. Objective To conduct a case finding feasibility and efficacy study for the detection of coeliac disease in community pharmacies. Setting Six community pharmacies across Sheffield, UK. Read More

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http://dx.doi.org/10.1007/s11096-019-00793-8DOI Listing
February 2019

Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy.

Authors:
Julius Sim

Theor Med Bioeth 2019 Feb 18. Epub 2019 Feb 18.

Institute for Primary Care and Health Sciences, Keele University, Staffordshire, ST5 5BG, UK.

Outcome-adaptive randomization (OAR) has been proposed as a corrective to certain ethical difficulties inherent in the traditional randomized clinical trial (RCT) using fixed-ratio randomization. In particular, it has been suggested that OAR redresses the balance between individual and collective ethics in favour of the former. In this paper, I examine issues of welfare and autonomy arising in relation to OAR. Read More

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http://dx.doi.org/10.1007/s11017-019-09481-0DOI Listing
February 2019

Relation of lowering door-to-balloon time and mortality in ST segment elevation myocardial infarction patients undergoing percutaneous coronary intervention.

Clin Res Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Division of Cardiovascular Diseases and Internal Medicine, Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizmann Street, Tel-Aviv, Israel.

Background: Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend a door-to-balloon time (DBT) of ≤ 90 min for patients undergoing primary percutaneous coronary intervention (PCI). We aimed to investigate the possible impact of further reduction in DBT intervals beyond the 90 min cutoff on short and long-term outcomes among STEMI patients undergoing primary PCI.

Methods: We retrospectively studied 889 STEMI patients (median age 61 years, 83% men) who underwent successful primary PCI and had a DBT of ≤ 90 min. Read More

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http://dx.doi.org/10.1007/s00392-019-01438-6DOI Listing
February 2019

Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.

JAMA 2019 Feb;321(7):686-696

Department of Medicine, Division of Gerontology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Importance: Postoperative delirium is common following cardiac surgery and may be affected by choice of analgesic and sedative.

Objective: To evaluate the effect of postoperative intravenous (IV) acetaminophen (paracetamol) vs placebo combined with IV propofol vs dexmedetomidine on postoperative delirium among older patients undergoing cardiac surgery.

Design, Setting, And Participants: Randomized, placebo-controlled, factorial clinical trial among 120 patients aged 60 years or older undergoing on-pump coronary artery bypass graft (CABG) surgery or combined CABG/valve surgeries at a US center. Read More

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http://dx.doi.org/10.1001/jama.2019.0234DOI Listing
February 2019
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Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study.

Age Ageing 2019 Feb 19. Epub 2019 Feb 19.

Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Research, University of Aberdeen, Aberdeen, UK.

Background: frail patients in any age group are more likely to die than those that are not frail. We aimed to evaluate the impact of frailty on clinical mortality, readmission rate and length of stay for emergency surgical patients of all ages.

Methods: a multi-centre prospective cohort study was conducted on adult admissions to acute surgical units. Read More

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http://dx.doi.org/10.1093/ageing/afy217DOI Listing
February 2019

Investing in Public Health Microbiology Laboratories in Western Balkan Countries Enhances Health Security From Communicable Disease Threats in Europe.

Front Public Health 2019 4;7. Epub 2019 Feb 4.

International Relations Section, European Centre for Disease Prevention and Control, Stockholm, Sweden.

The European Centre for Disease Prevention and Control (ECDC), under the EU enlargement policy, has supported national efforts of Western Balkan countries to strengthen their communicable disease prevention and control systems. The new EU strategy "A credible enlargement perspective for and enhanced EU engagement with the Western Balkans" advocates transformation processes that will build the foundation of EU-oriented national reforms. Well-functioning public health microbiology laboratories are key for early detection and control of infectious diseases, and thus maintaining and enhancing health security in Europe. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369834PMC
February 2019

RNA-Binding Proteins in the Control of LPS-Induced Macrophage Response.

Front Genet 2019 4;10:31. Epub 2019 Feb 4.

Department of Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany.

Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB) in different pathway branches and ultimately induces inflammatory cytokine and chemokine expression, macrophage migration and phagocytosis. Timely gene transcription and post-transcriptional control of gene expression confer the adequate synthesis of signaling molecules. Read More

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http://dx.doi.org/10.3389/fgene.2019.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369361PMC
February 2019

Preoperative Interventions for Alcohol and Other Recreational Substance Use: A Systematic Review and Meta-Analysis.

Front Psychol 2019 4;10:34. Epub 2019 Feb 4.

School of Psychology, University of Leeds, Leeds, United Kingdom.

Preoperative alcohol and other recreational substance use (ORSU) may catalyze perioperative complications. Accordingly, interventions aiming to reduce preoperative substance use are warranted. Studies investigating interventions to reduce alcohol and/or ORSU in elective surgery patients were identified from: Cochrane Library; MEDLINE; PSYCINFO; EMBASE; and CINAHL. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369879PMC
February 2019

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Authors:
Anne E Justice Tugce Karaderi Heather M Highland Kristin L Young Mariaelisa Graff Yingchang Lu Valérie Turcot Paul L Auer Rebecca S Fine Xiuqing Guo Claudia Schurmann Adelheid Lempradl Eirini Marouli Anubha Mahajan Thomas W Winkler Adam E Locke Carolina Medina-Gomez Tõnu Esko Sailaja Vedantam Ayush Giri Ken Sin Lo Tamuno Alfred Poorva Mudgal Maggie C Y Ng Nancy L Heard-Costa Mary F Feitosa Alisa K Manning Sara M Willems Suthesh Sivapalaratnam Goncalo Abecasis Dewan S Alam Matthew Allison Philippe Amouyel Zorayr Arzumanyan Beverley Balkau Lisa Bastarache Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Erwin P Bottinger Donald W Bowden Ivan Brandslund Linda Broer Amber A Burt Adam S Butterworth Mark J Caulfield Giancarlo Cesana John C Chambers Daniel I Chasman Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Francis S Collins James P Cook Amanda J Cox David S Crosslin John Danesh Paul I W de Bakker Simon de Denus Renée de Mutsert George Dedoussis Ellen W Demerath Joe G Dennis Josh C Denny Emanuele Di Angelantonio Marcus Dörr Fotios Drenos Marie-Pierre Dubé Alison M Dunning Douglas F Easton Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Myriam Fornage Caroline S Fox Paul W Franks Nele Friedrich Wei Gan Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Giorgia Girotto Mathias Gorski Harald Grallert Niels Grarup Megan L Grove Stefan Gustafsson Jeff Haessler Torben Hansen Andrew T Hattersley Caroline Hayward Iris M Heid Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Yi-Jen Hung Kristian Hveem M Arfan Ikram Erik Ingelsson Anne U Jackson Gail P Jarvik Yucheng Jia Torben Jørgensen Pekka Jousilahti Johanne M Justesen Bratati Kahali Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Frank Kee Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Peter Kovacs Bernhard K Krämer Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Wen-Jane Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Jian'an Luan Leo-Pekka Lyytikäinen Stuart MacGregor Reedik Mägi Satu Männistö Gaëlle Marenne Jonathan Marten Nicholas G D Masca Mark I McCarthy Karina Meidtner Evelin Mihailov Leena Moilanen Marie Moitry Dennis O Mook-Kanamori Anna Morgan Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Narisu Narisu Christopher P Nelson Matt Neville Ioanna Ntalla Jeffrey R O'Connell Katharine R Owen Oluf Pedersen Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Ailith Ewing Ozren Polasek Olli T Raitakari Asif Rasheed Chelsea K Raulerson Rainer Rauramaa Dermot F Reilly Alex P Reiner Paul M Ridker Manuel A Rivas Neil R Robertson Antonietta Robino Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo Segura-Lepe Xueling Sim Andrew J Slater Kerrin S Small Blair H Smith Jennifer A Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Karin M A Swart Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Mina Torres Emmanouil Tsafantakis Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Cornelia M van Duijn Mauno Vanhala Rohit Varma Sita H Vermeulen Henrik Vestergaard Veronique Vitart Thomas F Vogt Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao He Zheng Wei Zhou M Carola Zillikens Fernando Rivadeneira Ingrid B Borecki J Andrew Pospisilik Panos Deloukas Timothy M Frayling Guillaume Lettre Karen L Mohlke Jerome I Rotter Zoltán Kutalik Joel N Hirschhorn L Adrienne Cupples Ruth J F Loos Kari E North Cecilia M Lindgren

Nat Genet 2019 Feb 18. Epub 2019 Feb 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Read More

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http://dx.doi.org/10.1038/s41588-018-0334-2DOI Listing
February 2019

A pilot eConsultation service in Eastern Ontario: bridging clinical genetics and primary care.

Eur J Hum Genet 2019 Feb 18. Epub 2019 Feb 18.

Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

With the rising demand for clinical genetics services, it is a challenge for clinical geneticists to meet the needs of patients and referring primary care providers in a timely way, using current models of genetics health care delivery. One method of providing primary care providers with greater access to clinical genetics expertise is through an electronic consultation (eConsult) service. We describe here a pilot project of a clinical genetics eConsult service that our genetics centre in Eastern Ontario, Canada provided, using the Champlain Building Access to Specialists through eConsultation (BASE) web-based application. Read More

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http://dx.doi.org/10.1038/s41431-019-0342-4DOI Listing
February 2019

The role of oral magnesium supplements for the management of stable bronchial asthma: a systematic review and meta-analysis.

NPJ Prim Care Respir Med 2019 Feb 18;29(1). Epub 2019 Feb 18.

King Saud bin Abdul-Aziz University for Health Sciences; National & Gulf Center for Evidence Based Health Practice, King Abdullah International Medical Research Center, Family Medicine & Primary Healthcare Department, King Abdul-Aziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Asthma is a chronic lung disease characterized by airway inflammation and hyper-responsiveness of airway smooth muscles. There is growing evidence that magnesium may have a role in managing asthma through its dual effect as an anti-inflammatory and bronchodilating agent. To assess the efficacy of oral magnesium supplements in chronic asthmatic patients. Read More

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http://dx.doi.org/10.1038/s41533-019-0116-zDOI Listing
February 2019

Oral versus single intravenous bolus dose antibiotic prophylaxis against postoperative surgical site infection in external dacryocystorhinostomy for primary acquired nasolacrimal duct obstruction - A randomized study.

Indian J Ophthalmol 2019 Mar;67(3):382-385

Ophthalmic Plastics, Orbit and Ocular Oncology Services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Purpose: To compare the efficacy of a single perioperative bolus dose of intravenous antibiotic versus postoperative oral antibiotic prophylaxis for prevention of surgical site infection (SSI) in external dacryocystorhinostomy (DCR) for primary acquired nasolacrimal duct obstruction (PANDO).

Methods: This was a prospective randomized controlled study with a noninferiority design. Patients undergoing external DCR surgery were randomized into two groups A and B. Read More

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http://www.ijo.in/text.asp?2019/67/3/382/250759
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http://dx.doi.org/10.4103/ijo.IJO_616_18DOI Listing
March 2019
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Clinical effectiveness of single dose of intravenous dexamethasone on the duration of ropivacaine axillary brachial plexus block: the randomized placebo-controlled ADEXA trial.

Reg Anesth Pain Med 2019 Mar;44(3)

Department of Anesthesiology and Intensive Care Medicine, University Hospital of Besancon, Bourgogne Franche-Comte University, Besancon, France.

Background And Objectives: The effect of intravenous dexamethasone on the duration of axillary plexus block performed using ropivacaine is not described. The aim of this study is to assess the effect of intravenous dexamethasone on the duration of axillary plexus block analgesia after distal upper arm surgery.

Methods: In this prospective, randomized, placebo-controlled, double-blinded trial, consenting patients scheduled for hand or forearm surgery under ultrasound-guided axillary plexus block performed using 0. Read More

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http://dx.doi.org/10.1136/rapm-2018-100035DOI Listing

Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study.

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Department of Oncology, University of Cambridge, Cambridge, UK.

Background: Lung cancer 5-year survival has doubled over 15 years. Although the risk of second primary cancer is recognised, quantification over time is lacking. We describe the incidence of second and higher order smoking-related primary cancers in lung cancer survivors, identifying high-incidence groups and how incidence changes over time from first diagnosis. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212456DOI Listing
February 2019

Effect of Facility on Operative Costs of Total Ankle Arthroplasties.

J Surg Orthop Adv 2018 ;27(4):321-324

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.

Cost containment and bundled payments are becoming increasingly important in health care. The purpose of this study was to investigate if ambulatory surgery centers (ASCs) can deliver lower cost care and to identify sources of those cost savings in total ankle replacement (TAR). A cost identification analysis of primary TAR was performed at a single academic medical center. Read More

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January 2018

[Follow-up recommendations for the late preterm infant].

An Pediatr (Barc) 2019 Feb 15. Epub 2019 Feb 15.

Grupo SEN34-36/ACUNA, Sociedad Española de Neonatología, España; Servicio de Pediatría-Neonatología, SCIAS, Hospital Barcelona, Barcelona, España.

The population of late preterm infants (PT), those born between 34+0 and 36+6 weeks of gestation, accounts for 70-74% of all premature infants, and is not specifically included in most of the follow-up protocols for preterm infants. For many years, PTs have been handled as if they were term newborns, which has led to a limited knowledge of their outcome in the medium and long term. Their neonatal morbidity is associated with a higher incidence of postnatal complications, with an increased rate of hospital re-admissions due to malnutrition, hyperbilirubinaemia, and respiratory problems, when compared to term infants. Read More

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http://dx.doi.org/10.1016/j.anpedi.2019.01.008DOI Listing
February 2019

Immigrant Children With Special Health Care Needs: A Review.

Authors:
Sandra McKay

Curr Probl Pediatr Adolesc Health Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at Houston, TX. Electronic address:

This review was conducted to evaluate the current literature surrounding immigrant children with special health care needs. The focus of the review was to determine what evaluations have been done to educate primary care providers on general characteristics of this high-risk population and barriers that may impact care of the child. A review of the literature was conducted looking at PUBMED/MEDLINE and Cochrane databases. Read More

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http://dx.doi.org/10.1016/j.cppeds.2019.01.004DOI Listing
February 2019

Implementation and Evaluation of a Diabetic Ketoacidosis Order Set in Pediatric Type 1 Diabetes at a Tertiary Care Hospital: A Quality-Improvement Initiative.

Can J Diabetes 2018 Dec 26. Epub 2018 Dec 26.

Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Royal University Hospital, Saskatoon, Saskatchewan, Canada. Electronic address:

Objectives: Despite published clinical practice guidelines in pediatrics for the use of a standardized diabetic ketoacidosis (DKA) protocol, our centre lacked an accepted, evidence-informed protocol for pediatric DKA management. Our primary aim was to attain broad clinical uptake of a DKA order set. Secondary aims included improved standard-of-care DKA management principles regarding fluid, potassium and dextrose administration. Read More

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http://dx.doi.org/10.1016/j.jcjd.2018.12.005DOI Listing
December 2018