1,481,154 results match your criteria Primary Care & Community Psychiatry[Journal]


[Acetabular Revision: Reconstruction of Cavitary and Segmental Defects with Special Consideration of Modular Highly Porous Acetabular Revision Systems].

Z Orthop Unfall 2018 Dec 14;156(6):692-703. Epub 2018 Dec 14.

Klinik für Orthopädie, Universitätsklinikum Ulm.

Due to the increasing number of primary hip arthroplasty procedures, revision surgery will be an increasing challenge. The surgeon is frequently confronted with important acetabular defects. Careful preoperative planning is essential to achieve functional and long-term success. Read More

View Article
December 2018

Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Neonatology, Department of Paediatrics, CHU de Québec, Université Laval, Québec City, Québec, Canada.

Background:  Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI) has been used for 12 years in our institution for the management of refractory PPHN despite the gaps in the literature to support this use. Read More

View Article
December 2018

Disease Severity and Depressive Symptoms in Adolescents With Inflammatory Bowel Disease: The Mediating Role of Parent and Youth Illness Uncertainty.

J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.

Oklahoma State University.

Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD).

Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1. Read More

View Article
December 2018

Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease.

J Crohns Colitis 2018 Dec 14. Epub 2018 Dec 14.

The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA.

Background And Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize the diagnostic histological findings in patients with VEO-IBD as compared to older onset pediatric IBD and determine if there are unique pathological changes that can shed light on the driving forces of the disease, particularly immunodeficiencies. Read More

View Article
December 2018

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

View Article
December 2018

Responses of propagule germination and sexual reproduction of submerged macrophytes exposed to cadmium.

Chemosphere 2018 Dec 8;219:436-443. Epub 2018 Dec 8.

Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China; Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China. Electronic address:

Submerged macrophytes are considered the main primary producers in shallow lakes. Recently, they have experienced a decline due to increasing environmental impacts, e.g. Read More

View Article
December 2018

Stakeholder perspectives on implementing fentanyl drug checking: Results from a multi-site study.

Drug Alcohol Depend 2018 Nov 13;194:527-532. Epub 2018 Nov 13.

Department of Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Hampton House 163, Baltimore, MD, USA.

Background: The opioid epidemic is one of the greatest public health crises of our times, driven increasingly by synthetic opioids such as fentanyl in the heroin supply. The implementation of drug checking in community settings has the potential to reduce the burden of fatal overdose, provide harm reduction education around safer drug consumption, and increase health access among people who use drugs (PWUD). To inform program development, we explored stakeholder opinions on drug checking technologies and implementation considerations. Read More

View Article
November 2018

Origin of neck pain and direction of movement influence dynamic cervical joint motion and pressure pain sensitivity.

Clin Biomech (Bristol, Avon) 2018 Dec 5;61:120-128. Epub 2018 Dec 5.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health and Science Technology, Faculty of Medicine, Aalborg University, Denmark.

Background: Patients with neck pain normally showed alterations in cervical motion and pressure pain sensitivity. Cervical joints show scattered motions opposite to (anti-directional) the primary motion direction (pro-directional) during dynamic cervical flexion and extension. This study aimed to assess dynamic cervical joint motion and pressure pain sensitivity when pain originated from different cervical muscles which may have clinical relevance in diagnosis of impairments related with neck pain. Read More

View Article
December 2018

Mobilising evidence to improve nursing practice: A qualitative study of leadership roles and processes in four countries.

Int J Nurs Stud 2018 Nov 27;90:21-30. Epub 2018 Nov 27.

School of Education, Health, and Social Studies, Dalarna University, Falun, Sweden.

Background: The approach and style of leaders is known to be an important factor influencing the translation of research evidence into nursing practice. However, questions remain as to what types of roles are most effective and the specific mechanisms through which influence is achieved.

Objectives: The aim of the study was to enhance understanding of the mechanisms by which key nursing roles lead the implementation of evidence-based practice across different care settings and countries and the contextual factors that influence them. Read More

View Article
November 2018

Estimating the probability of abusive head trauma after abuse evaluation.

Child Abuse Negl 2018 Dec 11;88:266-274. Epub 2018 Dec 11.

Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, United States.

Background: Evidence-based, patient-specific estimates of abusive head trauma probability can inform physicians' decisions to evaluate, confirm, exclude, and/or report suspected child abuse.

Objective: To derive a clinical prediction rule for pediatric abusive head trauma that incorporates the (positive or negative) predictive contributions of patients' completed skeletal surveys and retinal exams.

Participants And Setting: 500 acutely head-injured children under three years of age hospitalized for intensive care at one of 18 sites between 2010 and 2013. Read More

View Article
December 2018

Effects of antiplatelet therapy on the mortality rate of patients with sepsis: A meta-analysis.

J Crit Care 2018 Dec 5;50:162-168. Epub 2018 Dec 5.

Department of Intensive Care Unit, The First Hospital of China Medical University, Nanjing Bei Street 155, Shenyang 110001, Liaoning Province, PR China. Electronic address:

Purpose: Abnormal platelet activation plays an important role in the development of sepsis. The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This meta-analysis aimed to determine the effect of antiplatelet drugs on the prognosis of patients with sepsis. Read More

View Article
December 2018

The high prevalence of pre-existing mental health complaints in clients attending Saint Mary's Sexual Assault Referral Centre: Implications for initial management and engagement with the Independent Sexual Violence Advisor service at the centre.

J Forensic Leg Med 2018 Dec 5;61:102-107. Epub 2018 Dec 5.

Saint Mary's Sexual Assault Referral Centre, York Place, Oxford Road, Manchester, M13 9WL, UK. Electronic address:

Background: The Saint Mary's Sexual Assault Referral Centre has a unique service delivery model whereby it provides an integrated physical and psychological support services to clients, women men and children, living in Greater Manchester. The service is available to those who have reported rape or sexual assault, whether this is recent or historic. Clients living in surrounding areas of Cheshire are provided with forensic and medical services at Saint Mary's Centre, with follow-up care provided locally, as appropriate. Read More

View Article
December 2018

Prediction of CH emissions from potential natural wetlands on the Tibetan Plateau during the 21st century.

Sci Total Environ 2018 Nov 28;657:498-508. Epub 2018 Nov 28.

Sichuan Climate Centre, Chengdu 610071, China.

The alpine wetlands on the Tibetan Plateau (TP) are ecosystems vulnerable to global climate change. It has been recognized that future climate change may have a significant impact on methane (CH) emissions from the plateau, while less attention has been paid to predicting temporal and spatial variations in CH emissions from TP natural wetlands. In this study, we used an integrated model framework based on the CH4MOD, TOPMODEL and TEM models to predict CH emissions from potential natural wetlands on the TP under IPCC AR5 scenarios from 2006 to 2100. Read More

View Article
November 2018
1 Read

The sources and dynamics of fine-grained sediment degrading the Freshwater Pearl Mussel (Margaritifera margaritifera) beds of the River Torridge, Devon, UK.

Sci Total Environ 2018 Nov 28;657:420-434. Epub 2018 Nov 28.

Sustainable Agriculture Sciences Department, Rothamsted Research, North Wyke, Okehampton EX20 2SB, UK.

The Freshwater Pearl Mussel (Margaritifera margaritifera) is an endangered organism across its entire range. It has a complex life cycle and stringent habitat requirements and is therefore an indicator species for the general ecosystem health of host rivers. Whereas historical intensive pearl fishing contributed to population declines, excess nutrient and sediment loss associated with current land use pressures in host river catchments, including modern intensive farming practices, are now highlighted as primary contributory factors. Read More

View Article
November 2018

Dependence of initial silica scaling on the surface physicochemical properties of reverse osmosis membranes during bench-scale brackish water desalination.

Water Res 2018 Nov 30;150:358-367. Epub 2018 Nov 30.

School of Environment, Beijing Normal University, No. 19, Xinjiekouwai Street, Beijing, 100875, China; Department of Environmental Health and Engineering, Bloomberg School of Public Health, The John Hopkins University, 615 North Wolfe Street, MD, 21205, USA. Electronic address:

Silica scaling of reverse osmosis membranes in brackish water desalination is less understood than hardness scaling due to the complex silica behaviors at the membrane/water interface. In this study, -COOH, -SOH, -NH and -OH functional groups were introduced onto polyamide membranes to create distinct surface physicochemical properties. The resulting membranes were further studied under similar scaling conditions to yield temporal flux loss data that were empirically interpreted by a logistic growth model. Read More

View Article
November 2018

Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-κB/COX-2 signaling pathways.

Cancer Lett 2018 Dec 10. Epub 2018 Dec 10.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou, China. Electronic address:

MLL-rearranged leukemia is an aggressive malignancy associated with poor outcome, which is refractory to conventional treatment. Melatonin has been proven to exert anti-tumor activity, but the effect of melatonin on MLL-r leukemia and the underlying mechanism remain poorly understood. In this study, melatonin inhibited cell proliferation and induced apoptosis by activating the caspase-dependent apoptotic pathway in MLL-r leukemia cells. Read More

View Article
December 2018

Induction of protective immunity by recombinant peptidoglycan associated lipoprotein (rPAL) protein of Legionella pneumophila in a BALB/c mouse model.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Department of Microbiology, Faculty of Advanced Sciences, Medical Sciences University Islamic Azad, Tehran, Iran.

Legionella pneumophila causes a severe form of pneumonia known as Legionnaires' disease especially in patients with impaired cellular immune response. In order to prevent the disease, immunogenicity and the level of the induction of protective immunity from the recombinant peptidoglycan-associated lipoprotein (rPAL) against Legionella pneumophila in BALB/c mice was examined. Mice immunized with (rPAL) rapidly increased an antibody response in serum and also displayed a strong activation of both innate and adaptive cell-mediated immunity as determined by antigen-specific splenocyte proliferation, an early production of pro-inflammatory cytokines in the serum and in the splenocyte cultures. Read More

View Article
December 2018

A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care.

J Pain Symptom Manage 2018 Dec 11. Epub 2018 Dec 11.

Division of Palliative Care, Dept of Medicine, University of Ottawa; Ottawa, ON, Canada; Bruyère Continuing Care; Ottawa, ON, Canada; Bruyère Research Institute; Ottawa, ON, Canada; Ottawa Hospital Research Institute; Ottawa, ON, Canada.

Context: Based on the clinical care pathway of delirium in palliative care (PC), a published analytic framework (AF) formulated research questions in key domains and recommended a scoping review to identify evidence gaps.

Objectives: To produce a literature map for key domains of the published AF: screening; prognosis and diagnosis; management and the health-related outcomes.

Methods: A standard scoping review framework was used by an interdisciplinary study team of nurse and physician delirium researchers, an information specialist and review methodologists to conduct the review. Read More

View Article
December 2018

Tezepelumab, an anti-TSLP monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

MedImmune, Cambridge, UK.

Background: Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody, targets thymic stromal lymphopoietin, a cytokine implicated in atopic dermatitis (AD) pathogenesis.

Objective: Evaluate efficacy and safety of tezepelumab in adults with moderate to severe AD.

Methods: In this phase 2a study (NCT02525094), 113 patients were randomized 1:1 to subcutaneous tezepelumab 280 mg or placebo every 2 weeks, plus Class 3 topical corticosteroids (TCS). Read More

View Article
December 2018

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2018 Dec 11. Epub 2018 Dec 11.

Molecular & Integrative Physiology, University of Michigan School of Public Health, Ann Arbor MI; Internal Medicine Division of Gastroenterology, University of Michigan School of Public Health, Ann Arbor MI; Rogel Cancer Center. University of Michigan Medical School, Ann Arbor MI. Electronic address:

Background & Aims: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis.

Methods: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1) and wild-type littermates (LysMCre;Mcl1, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. Read More

View Article
December 2018

Increasing prevalence of the epidemic ribotype 106 in healthcare facility-associated and community-associated Clostridioides difficile infection.

Anaerobe 2018 Dec 11. Epub 2018 Dec 11.

Microbiology Department, Hospital Universitari Son Espases and Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain. Electronic address:

Clostridioides difficile is the leading cause of nosocomial diarrhea and antibiotics associated diarrhea, but it is also an increasingly common cause of community diarrhea. In recent years we have observed a progressive increase in the incidence of C. difficile infection (CDI) both at the hospital and community setting that could be explained by the dynamic epidemiology of C. Read More

View Article
December 2018

Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Division of Respiratory Medicine, Department of Paediatrics, University Hospital Bern, Bern, Switzerland; Institute of Virology and Immunology, Bern, Switzerland; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. Electronic address:

Introduction: Rhinovirus (RV) infection is a major cause of cystic fibrosis (CF) lung morbidity with limited therapeutic options. Various diseases involving chronic inflammatory response and infection are associated with endoplasmic reticulum (ER) stress and subsequent activation of the unfolded protein response (UPR), an adaptive response to maintain cellular homeostasis. Recent evidence suggests impaired ER stress response in CF airway epithelial cells, this might be a reason for recurrent viral infection in CF. Read More

View Article
December 2018

Organoid Modeling of the Tumor Immune Microenvironment.

Cell 2018 Dec;175(7):1972-1988.e16

Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly elusive. Here, an air-liquid interface (ALI) method propagated patient-derived organoids (PDOs) from >100 human biopsies or mouse tumors in syngeneic immunocompetent hosts as tumor epithelia with native embedded immune cells (T, B, NK, macrophages). Read More

View Article
December 2018

Vaginal dysbiosis, and the risk of human papillomavirus and cervical cancer: systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics & Gynecology, Ghent University, Ghent, Belgium.

Objective: The vaginal microbiota proposedly influence the association between human papillomavirus and cervical cancer. Our aim was to assess if vaginal dysbiosis affects human papilloma virus acquistion, persistence, and progression to related cervical pre-malignancy.

Data Soruces: MEDLINE, Embase, CINAHL, Cochrane Library, and Web of Science (inception until June 2018). Read More

View Article
December 2018

Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia.

Cell Signal 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Chronic kidney disease (CKD) is a global health problem with a profound impact on quality of life. Cardiovascular disease is established as a major cause of morbidity and mortality in patients with CKD. Dyslipidemia is frequently observed in CKD patients, suggesting a causal relation between dyslipidemia and cardiovascular disease in CKD patients. Read More

View Article
December 2018

At The Knees: Inguinoscrotal Hernia.

Am J Med 2018 Dec 11. Epub 2018 Dec 11.

Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, TX.

View Article
December 2018

Impact of hospital hospitality house programs on quality of life and mood of patients and caregivers after hematopoietic stem cell transplant.

Hematol Oncol Stem Cell Ther 2018 Dec 9. Epub 2018 Dec 9.

Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Objective/background: The quality of life (QOL) of hematopoietic stem cell transplant (HSCT) patients and their caregivers decreases during the first 8 days after HSCT.

Methods: This prospective pilot study collected preliminary data on the impact of posttransplant living arrangements (hospital hospitality house [HHH] vs. hotel, apartment, or house ["hotel"]) and other factors on the QOL of HSCT patients and their caregivers. Read More

View Article
December 2018

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database Syst Rev 2018 Dec 14;12:CD012939. Epub 2018 Dec 14.

ENT Department, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK, CB2 0QQ.

Background: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Read More

View Article
December 2018

Optogenetic control of iPS cell-derived neurons in 2D and 3D culture systems using channelrhodopsin-2 expressed by the SYN1 and CaMKII promoters.

J Tissue Eng Regen Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, Old Road Campus Research Building, University of Oxford, UK.

Development of optogenetically controllable human neural network model in three-dimensional (3D) can provide an investigative system that is physiologically relevant or mimic to the human brain. Light-sensitive neurons were generated by transducing channelrhodopsin-2 (ChR2) into human induced pluripotent stem cells (hiPSCs) derived neural progenitor cells (Axol) using lentiviruses and cell-type specific promoters. A mixed population of human iPSC-derived cortical neurons, astrocytes and progenitor cells was obtained (Axol-ChR2) upon neural differentiation. Read More

View Article
December 2018

Associations of Patient Experience in Primary Care With Hospitalizations and Emergency Department Visits on Isolated Islands: A Prospective Cohort Study.

J Rural Health 2018 Dec 14. Epub 2018 Dec 14.

Department of Family and Community Medicine, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

Purpose: In rural areas, the management of hospitalizations and emergency department (ED) visits is an important issue, and it is compounded by factors such as the long distance to secondary care facilities, funding difficulties in many rural medical institutions, and shortage of medical staff. While better patient experience (PX) has been shown to reduce hospitalizations and ED visits, previous studies have not considered the differences between urban and rural areas. In addressing this gap, this study examines the association between PX and hospitalizations/ED visits on isolated islands. Read More

View Article
December 2018

Polymorphisms in the myeloid differentiation primary response 88 pathway do not explain low expression levels in sudden infant death syndrome.

Acta Paediatr 2018 Dec 14. Epub 2018 Dec 14.

Department of Forensic Sciences, Section of Paediatric Forensic Medicine, Oslo University Hospital, Oslo, Norway.

Aim: The aim of this study was to investigate if a range of known rare and common genetic variants in the Toll-like receptor 4 (TLR4) / myeloid differentiation primary response 88 (MyD88) pathway were present or overrepresented in sudden infant death syndrome (SIDS) compared to controls.

Methods: Genetic variations in the genes encoding TLR4, MyD88 and Interleukin-1 receptor-associated kinase 4 were analysed. The subjects investigated included 158 SIDS cases with a median age of 15. Read More

View Article
December 2018

Development and initial validation of the Positive Sexuality Scale for female adults.

Authors:
Giulia Casu

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychology, University of Bologna, Bologna, Italy.

Aim And Objectives: To develop and initially validate the Positive Sexuality Scale (PSS) to assess adult female positive sexuality.

Background: While traditional approaches focus on negative sexual experiences and sexual dysfunctions, within the positive psychology framework positive sexuality is a subjective experience of happiness and fulfillment with one's sexual expression, which contributes to well-being. No measure exists that specifically measures adult female positive sexuality and can be confidently used with women of any fertility/childlessness status. Read More

View Article
December 2018
1 Read

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5862-5867

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG).

Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Read More

View Article
December 2018

Nutritional risk index as a predictor of mortality in acutely decompensated heart failure.

PLoS One 2018 14;13(12):e0209088. Epub 2018 Dec 14.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Background: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF).

Methods: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41. Read More

View Article
December 2018
1 Read

Type VI collagen promotes lung epithelial cell spreading and wound-closure.

PLoS One 2018 14;13(12):e0209095. Epub 2018 Dec 14.

Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America.

Basement membrane (BM) is an essential part of the extracellular matrix (ECM) that plays a crucial role in mechanical support and signaling to epithelial cells during lung development, homeostasis and repair. Abnormal composition and remodeling of the lung ECM have been associated with developmental abnormalities observed in multiple pediatric and adult respiratory diseases. Collagen VI (COL6) is a well-studied muscle BM component, but its role in the lung and its effect on pulmonary epithelium is largely undetermined. Read More

View Article
December 2018
3.234 Impact Factor

Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality.

PLoS One 2018 14;13(12):e0208847. Epub 2018 Dec 14.

Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova de Lleida,IRBLleida, Universitat de Lleida, Lleida, Catalonia, Spain.

Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common reason for presentation to emergency departments (ED), but the management of these episodes is often heterogeneous regardless of their potential impact on short-term adverse outcomes.

Methods: This was a longitudinal, retrospective study of all patients >40 years old admitted to the ED of two Spanish teaching hospitals for an AECOPD between January 1st and May 31st, 2016. All data were collected from electronic medical records. Read More

View Article
December 2018

Musculoskeletal injuries and absenteeism among healthcare professionals-ICD-10 characterization.

PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.

Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.

Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More

View Article
December 2018

Geo-spatial analysis of individual-level needle and syringe coverage in Melbourne, Australia.

PLoS One 2018 14;13(12):e0209280. Epub 2018 Dec 14.

Behaviours and Health Risks, Burnet Institute, Melbourne, Victoria, Australia.

Distance to health services is known to be negatively associated with usage and needle and syringe programs (NSPs) for people who inject drugs (PWID) are no different. Australia has a mixture of NSP modalities (primary or secondary fixed-site NSPs), which may present unique barriers to access. In this study, we explore 1) the effect of distance to NSPs on individual-level needle and syringe coverage, and 2) differences in coverage dependent on NSP modality. Read More

View Article
December 2018

Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML.

PLoS One 2018 14;13(12):e0209295. Epub 2018 Dec 14.

Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

CD25 is expressed on leukemic cells in 10-20% cases of acute myeloid leukemia (AML), and its expression is associated with poor prognosis. We reevaluated the relationship between CD25 expression and the leukemia-initiating cell (LIC) properties of AML using a patient-derived xenograft model. We divided lineage marker-negative (Lin-) CD34+CD38- or Lin-CD34+ cells from CD25-positive AML into CD25-positive and -negative populations, and then transplanted each population into NOD. Read More

View Article
December 2018

Impact of a patient-flow physician coordinator on waiting times and length of stay in an emergency department: A before-after cohort study.

PLoS One 2018 14;13(12):e0209035. Epub 2018 Dec 14.

Division of Emergency Medicine, Department of Community, Primary Care and Emergency Medicine, Geneva University Hospitals and School of Medicine, Geneva, Switzerland.

Objective: Overcrowding is common in most emergency departments (ED). Despite the use of validated triage systems, some patients are at risk of delayed medical evaluation. The objective of this study was to assess the impact of a patient-flow physician coordinator (PFPC) on the proportion of patients offered medical evaluation within time limits imposed by the Swiss Emergency Triage Scale (SETS) and on patient flow within the emergency department of a teaching urban hospital. Read More

View Article
December 2018

Bayesian hierarchical vector autoregressive models for patient-level predictive modeling.

PLoS One 2018 14;13(12):e0208082. Epub 2018 Dec 14.

Department of Statistics, Columbia University, New York, NY, United States of America.

Predicting health outcomes from longitudinal health histories is of central importance to healthcare. Observational healthcare databases such as patient diary databases provide a rich resource for patient-level predictive modeling. In this paper, we propose a Bayesian hierarchical vector autoregressive (VAR) model to predict medical and psychological conditions using multivariate time series data. Read More

View Article
December 2018

Socio-demographic determinants as predictors of oral hygiene status and gingivitis in schoolchildren aged 7-12 years old: A cross-sectional study.

PLoS One 2018 14;13(12):e0208886. Epub 2018 Dec 14.

Dental Research Centers, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: Gingivitis and poor oral hygiene status are the most prevalent oral diseases among primary school students. Poor oral hygiene status, gingivitis and socio-demographic determinants have been shown to be associated with periodontal diseases. There is limited information on the gingivitis and oral hygiene status among Iranian children. Read More

View Article
December 2018

Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.

PLoS One 2018 14;13(12):e0209101. Epub 2018 Dec 14.

Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Introduction: Bladder cancer (urothelial carcinoma) is a common malignancy characterized by high recurrence rates and intense clinical follow-up, indicating the necessity for more effective therapies. Current treatment regimens include intra-vesical administration of mitomycin C (MMC) for non-muscle invasive disease and systemic cisplatin for muscle-invasive or metastatic disease. Hyperthermia, heating a tumor to 40-44°C, enhances the efficacy of these chemotherapeutics by various modes of action, one of which is inhibition of DNA repair via homologous recombination. Read More

View Article
December 2018

Novel mass spectrometry based detection and identification of variants of rabies virus nucleoprotein in infected brain tissues.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006984. Epub 2018 Dec 14.

Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

Human rabies is an encephalitic disease transmitted by animals infected with lyssaviruses. The most common lyssavirus that causes human infection is rabies virus (RABV), the prototypic member of the genus. The incubation period of RABV in humans varies from few weeks to several months in some instances. Read More

View Article
December 2018

Combined therapy with levothyroxine and liothyronine for hypothyroidism.

Medwave 2018 Dec 14;18(8):e7376. Epub 2018 Dec 14.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: The usual supplementation for hypothyroidism is based on monotherapy with levothyroxine. However, some patients persist with symptoms attributable to the deficit of thyroid hormone. It has been suggested that the a combined treatment with liothyronine and levothyroxine would provide a greater benefit. Read More

View Article
December 2018

Topical tranexamic acid for spontaneous epistaxis.

Medwave 2018 Dec 10;18(8):e7372. Epub 2018 Dec 10.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: Spontaneous epistaxis is one of the most frequent problems in emergency services. New treatment alternatives have emerged, including topical tranexamic acid. However, there is controversy about the actual efficacy of this alternative. Read More

View Article
December 2018

Laparoscopic versus open appendectomy for complicated appendicitis.

Medwave 2018 Dec 11;18(8):e7370. Epub 2018 Dec 11.

Proyecto Epistemonikos, Santiago, Chile; Centro Evidencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: The treatment of acute appendicitis using laparoscopy reduces the risk of wound infection, hospitalization time and return to normal activity. However, it increases the risk of intra-abdominal abscess, which is one the main complications of complicated appendicitis.

Methods: We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. Read More

View Article
December 2018

Serum Alkaline Phosphatase Predicts Poor Disease-Free Survival in Patients Receiving Radical Gastrectomy.

Med Sci Monit 2018 Dec 14;24:9073-9080. Epub 2018 Dec 14.

Department of General Surgery, Chinese People's Liberation Army 309th Hospital, Beijing, China (mainland).

BACKGROUND Serum alkaline phosphatase (ALP) has been proved to be a negative prognostic factor for several malignancies, but its clinical significance in gastric cancer (GC) patients has not been sufficiently studied. In the present retrospective study, we investigated the effect of serum ALP on disease-free survival (DFS) after radical gastrectomy. MATERIAL AND METHODS We included 491 GC patients receiving radical gastrectomy at the Chinese People's Liberation Army 309th Hospital. Read More

View Article
December 2018
1 Read

Acute Effects of Exercise Intensity on Insulin Sensitivity under Energy Balance.

Med Sci Sports Exerc 2018 Dec 13. Epub 2018 Dec 13.

Department of Human Studies.

Exercise is known to improve insulin sensitivity (SI), however studies to date have been confounded by negative energy deficits following exercise.

Purpose: The primary objective of this study was to assess the effect of 8-16 weeks of aerobic exercise training on the SI of untrained women under rigorously controlled energy balanced conditions. The secondary objective was to determine if one acute bout of moderate (MIC)- or high (HII)-intensity exercise further affected SI. Read More

View Article
December 2018

A Prospective Comparative Study Between Subcuticular and Sutureless Technique of Skin Closure Following External Dacryocystorhinostomy.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

Orbit Oculoplasty Reconstructive and Aesthetic Services, Aditya Birla Sankara Nethralaya, Kolkata, India.

Purpose: To compare the cosmetic outcome of the surgical scar of external dacryocystorhinostomy by the subcuticular versus sutureless technique.

Methods: This was a prospective interventional randomized control study conducted at tertiary level hospital. Fifty patients of primary-acquired nasolacrimal duct obstruction were included in this study. Read More

View Article
December 2018
1 Read
  • Page 1 of 29624