14,228 results match your criteria Primary Biliary Cirrhosis


Prognostic markers affecting the early recurrence of hepatocellular carcinoma with liver cirrhosis after curative resection.

Int J Biol Markers 2019 Apr 12:1724600819834306. Epub 2019 Apr 12.

1 Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea.

Background: Early recurrence is associated with poor prognosis after curative resection for hepatocellular carcinoma. Thus, we studied which factors, including this inflammation-based scoring system, affect disease recurrence in single hepatocellular carcinoma patients with liver cirrhosis.

Methods: A total of 430 consecutive hepatocellular carcinoma patients were enrolled in our institution between January 2002 and December 2015. Read More

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http://dx.doi.org/10.1177/1724600819834306DOI Listing
April 2019
1 Read

Influence of Type 2 Diabetes Mellitus and Preoperative Hemoglobin A1c Levels on Outcomes of Liver Transplantation.

Hepatol Commun 2019 Apr 20;3(4):574-586. Epub 2019 Feb 20.

Division of Gastroenterology, Hepatology, and Endoscopy Brigham and Women's Hospital Boston MA.

Liver transplant centers often establish hemoglobin A1c (HbA1C) criteria for candidates with type 2 diabetes mellitus (T2DM) based on data from other surgical specialties showing worse outcomes in patients with poor glycemic control. However, because of the reduced reliability of HbA1C in cirrhosis, it is unclear whether pretransplant HbA1C values are predictive of postoperative complications in liver recipients. We retrospectively examined the association between preoperative HbA1C and postoperative outcomes in 173 consecutive patients who underwent liver transplantation at the University of Cincinnati Medical Center between August 2012 and March 2015. Read More

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http://dx.doi.org/10.1002/hep4.1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442696PMC
April 2019
1 Read

Florid biliary duct lesions in an AMA -positive patient in absence of cholestatic liver biochemistry.

J Autoimmun 2019 Apr 8. Epub 2019 Apr 8.

Gastroenterology & Hepatology Department Hamad Medical Corporation, Qatar; Weill Cornell Medical College, Qatar Br, Qatar. Electronic address:

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, diagnosed by the presence of anti-mitochondrial antibodies (AMA) or highly PBC-specific anti-nuclear antibodies, in the appropriate context of cholestatic liver biochemistry. We present a case with histological features of destructive granulomatous lymphocytic cholangitis affecting interlobular and septal bile ducts suggestive of PBC, with strong positive AMA, Anti-M2 and anti-nuclear dot, but with persistently normal alkaline phosphatase (ALP). On the contrary to previous reports suggesting that those individuals in whom ALP remains persistently below 1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411193009
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http://dx.doi.org/10.1016/j.jaut.2019.04.004DOI Listing
April 2019
3 Reads

Long-Term Outcome of Endoscopic Retrograde Biliary Drainage (ERBD) of Biliary Stricture Following Living Donor Liver Transplantation.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: Biliary strictures remain one of the most challenging aspects after living donor liver transplantation (LDLT). The aim of this study is to assess long-term outcome of endoscopic treatment of biliary stricture occurring after LDLT and to identify risk factors of recurrent biliary stricture following endoscopic retrograde biliary drainage (ERBD) in LDLT.

Methods: A total of 1,441 patients underwent LDLT from May 1995 to May 2014. Read More

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http://dx.doi.org/10.5009/gnl18387DOI Listing
February 2019
1 Read

Escherichia coli-associated hemolytic uremic syndrome and severe chronic hepatocellular cholestasis: complication or side effect of eculizumab?

Pediatr Nephrol 2019 Apr 8. Epub 2019 Apr 8.

Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Bron, France.

Background: Liver lesions of hemolytic uremic syndrome due to Shiga-toxin-producing Escherichia coli (STEC-HUS) are uncommon.

Case-diagnosis/treatment: We report three observations of severe STEC-HUS with delayed hepatic involvement. They presented with multiple organ failure and received eculizumab; 15 days after the onset of STEC-HUS, cholestasis appeared and cytolysis worsened. Read More

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http://dx.doi.org/10.1007/s00467-019-04234-6DOI Listing
April 2019
3 Reads

Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long-term follow-up study of 1317 patients.

Aliment Pharmacol Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.

Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis.

Material And Methods: We used population-based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Read More

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http://doi.wiley.com/10.1111/apt.15255
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http://dx.doi.org/10.1111/apt.15255DOI Listing
April 2019
8 Reads

Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials.

Lipids Health Dis 2019 Apr 6;18(1):88. Epub 2019 Apr 6.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent.

Methods: PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile. A random-effect model and the generic inverse variance weighting method were used for quantitative data synthesis. Read More

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http://dx.doi.org/10.1186/s12944-019-1041-4DOI Listing
April 2019
2 Reads

Hepatitis C virus infection and cholangiocarcinoma: An insight into epidemiological evidences and hypothetical mechanisms of oncogenesis.

Am J Pathol 2019 Apr 3. Epub 2019 Apr 3.

Baylor Scott & White Digestive Disease Research Center, Temple, TX, USA; Division of Research, Central Texas Veterans Health Care System, Temple, TX, USA. Electronic address:

Hepatitis C Virus (HCV) infection is a global public health problem since it is a main cause of liver cirrhosis and hepatocellular carcinoma (HCC). This human oncogenic virus is also associated with the development of non-Hodgkin lymphoma and cholangiocarcinoma (CCA). The association between HCV infection and CCA has been examined in a number of epidemiological studies. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.018DOI Listing
April 2019
3 Reads

Emerging views of mitophagy in immunity and autoimmune diseases.

Autophagy 2019 Apr 5. Epub 2019 Apr 5.

a Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health , Inflammatory Bowel Disease Research Center.

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria as a powerful means employed by autophagy to keep the immune system in check. The process of mitophagy may restrict inflammatory cytokine secretion and directly regulate mitochondrial antigen presentation and immune cell homeostasis. Read More

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http://dx.doi.org/10.1080/15548627.2019.1603547DOI Listing
April 2019
1 Read

Secondary sclerosing cholangitis in critically ill patients.

Cir Cir 2019 ;86(1):49-55

Medical Management Office. Hospital General Naval de Alta Especialidad, Secretaría de Marina/Armada de México, Mexico City. Mexico.

Primary sclerosing cholangitis (PSC) is a rare idiopathic condition with immunopathogenic mechanisms where there is chronic progressive destruction of the biliary tree. Secondary sclerosing cholangitis (SSC) is clinically comparable to PSC, but is caused by specific processes which directly damage the biliary tree; examples include recurrent pancreatitis, bile duct malignancy, congenital bile duct abnormalities. A new cause of SSC has been described during or following significant critical illness associated with severe respiratory insufficiency, vasopressor requirement, shock and sepsis. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000008DOI Listing
January 2019
3 Reads

Primary biliary cholangitis with contemporary presence of anti-mithocondrial and anti-rods and rings autoantibodies: literature first case.

Authors:
Roberto Assandri

Gastroenterol Hepatol Bed Bench 2019 ;12(1):76-82

Clinical Investigation Laboratory, ASST Crema, Largo Ugo Dossena- Crema, Cremona, Italy.

Primary biliary cholangitis, previously known as primary biliary cirrhosis (PBC), is the most common autoimmune diseases of the liver (ALD). Patients with PBC may present with typical biliary pattern symptoms. Also the presence of anti-mitochondrial autoantibodies (AMAs) is the laboratory hallmark of PBC, which molecular target antigens are members of 2-oxoacid dehydrogenase complex of enzymes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441490PMC
January 2019
6 Reads

Hepatic Manifestations of Cystic Fibrosis.

Clin Liver Dis 2019 May 21;23(2):263-277. Epub 2019 Feb 21.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9B-16, MSC 1800, Bethesda, MD 20892, USA. Electronic address:

Cystic fibrosis liver disease (CFLD) remains the third leading cause of death in patients with cystic fibrosis. Although most patients with CFLD present in childhood, recent studies suggest a second wave of liver disease in adulthood. There are no clear guidelines for diagnosing CFLD. Read More

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http://dx.doi.org/10.1016/j.cld.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452885PMC
May 2019
1 Read

Patients with Cirrhosis of Liver Operated for Non-transplant Surgery: A Retrospective Analysis.

J Clin Transl Hepatol 2019 Mar 17;7(1):9-14. Epub 2019 Feb 17.

Department of Research, Institute of Liver & Biliary Sciences (ILBS), New Delhi, India.

Patients with cirrhosis of the liver have high mortality after surgery. We investigated the mortality in patients with cirrhosis of the liver who underwent surgery other than liver transplant and applied the Mayo clinic model to predict mortality and compare with the observed mortality. We also studied the association of the observed mortality with the Child-Turcotte-Pugh (CTP) class and the model for end-stage liver disease (MELD) and model for end-stage liver disease-sodium (MELD-Na) scores. Read More

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http://dx.doi.org/10.14218/JCTH.2018.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441638PMC
March 2019
4 Reads

Very low hepatitis C viral loads in treatment-naïve persons: do they compromise hepatitis C virus antigen testing?

Clin Infect Dis 2019 Apr 3. Epub 2019 Apr 3.

Institute of Global Health, University of Geneva, Geneva, Switzerland.

Background: Hepatitis C virus (HCV) antigen testing is less expensive than quantitative RT-PCR but has lower sensitivity for very low viral loads (VLVL; HCV RNA ≤3,000 IU/ml). Currently the benefits of antigen testing for screening are discussed, but data on prevalence and outcomes of persons with VLVL are scarce.

Methods: We assessed prevalence and predictors of VLVL by logistic regression in treatment-naïve participants in the Swiss Hepatitis C Cohort Study. Read More

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http://dx.doi.org/10.1093/cid/ciz270DOI Listing
April 2019
1 Read

Radix Sophorae flavescentis versus no intervention or placebo for chronic hepatitis B.

Cochrane Database Syst Rev 2019 Apr 3;4:CD013089. Epub 2019 Apr 3.

Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chaoyang District, Beijing, China, 100029.

Background: Hepatitis B virus (HBV) infection, a liver disease caused by hepatitis B virus, may lead to serious complications such as cirrhosis and hepatocellular carcinoma. People with HBV infection may have co-infections including HIV and other hepatitis viruses (hepatitis C or D), and co-infection may increase the risk of all-cause mortality. Chronic HBV infection increases morbidity and psychological stress and is an economic burden on people with chronic hepatitis B and their families. Read More

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http://dx.doi.org/10.1002/14651858.CD013089.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446139PMC
April 2019
3 Reads

Current and Promising Therapy for Primary Biliary Cholangitis.

Expert Opin Pharmacother 2019 Apr 1. Epub 2019 Apr 1.

a Mayo Clinic, Division of Gastroenterology and Hepatology , 200 1st St. SW, Rochester , MN.

Introduction: Primary biliary cholangitis is a chronic, cholestatic liver disease that may progress to cirrhosis with complications of end-stage liver disease. Approved treatment options include ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) but novel therapies are being investigated. Areas covered: In this review, the authors describe the current pharmacotherapy for the treatment of primary biliary cholangitis (PBC) and for management of side effects such as pruritus and fatigue based on the currently available literature. Read More

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http://dx.doi.org/10.1080/14656566.2019.1601701DOI Listing
April 2019
9 Reads

Hepatic artery reconstruction in living donor liver transplantation: strategy of the extension of graft or recipient artery.

J Plast Surg Hand Surg 2019 Mar 31:1-5. Epub 2019 Mar 31.

a Department of Plastic and Reconstructive Surgery , Teikyo University , Itabashiku , Japan.

In living donor liver transplantation (LDLT) patients, the reconstruction of insufficiently long hepatic artery (HA) is difficult. However, no report has described the relationship between the length of HA and its reconstructive procedure. Herein, we aimed to identify the risk factors for the requirement of additional reconstructive procedures of direct anastomosis. Read More

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http://dx.doi.org/10.1080/2000656X.2019.1582426DOI Listing
March 2019
1 Read

Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.

Biochem Biophys Res Commun 2019 May 27;512(4):770-778. Epub 2019 Mar 27.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China. Electronic address:

Cholestasis, which is characterized by bile acid (BA) overload within the hepatocytes, is a major contributor to liver injury. The dysregulation of bile acid homeostasis, such as excessive bile acid synthesis and defected secretion, leads to intracellular retention of hydrophobic bile acid which undermines the physiological function of hepatocytes. Cholestasis can further develop into hepatic fibrosis and cirrhosis, and eventually life-threating liver failure. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.131DOI Listing
May 2019
2.297 Impact Factor

microRNA-21 expressions impact on liver fibrosis in biliary atresia patients.

BMC Res Notes 2019 Mar 29;12(1):189. Epub 2019 Mar 29.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Objective: Biliary atresia (BA) is the most common cause of neonatal jaundice, characterized by progressive and rapid liver fibrosis. Recent studies have shown that microRNAs (miRNAs) contribute to the liver fibrogenesis. We investigated the miRNA-21 impact in liver fibrogenesis in Indonesian BA patients. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441216PMC
March 2019
2 Reads

Effects of Caffeine Treatment on Hepatopulmonary Syndrome in Biliary Cirrhotic Rats.

Int J Mol Sci 2019 Mar 28;20(7). Epub 2019 Mar 28.

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan.

Hepatopulmonary syndrome (HPS) is a lethal complication of cirrhosis characterized by hypoxia and overt intrapulmonary shunting. In this study, we investigated the effect of caffeine in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS. CBDL rats were randomly allocated to receive caffeine or vehicle for 14 days. Read More

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http://dx.doi.org/10.3390/ijms20071566DOI Listing
March 2019
1 Read

Changes in liver morphology in patients with extrahepatic portal venous obstruction: a retrospective magnetic resonance imaging study.

Br J Radiol 2019 Apr 9:20180890. Epub 2019 Apr 9.

2 Radiodiagnosis and Imaging, PGIMER , Chandigarh , India.

Objective: To investigate the liver parenchymal changes on MRI in patients with extrahepatic portal venous obstruction (EHPVO).

Methods: This was a retrospective evaluation of the MRI studies in patients with EHPVO between January 2016 and April 2018. The diagnosis of EHPVO in each case had been established on the basis of clinical and Doppler parameters. Read More

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http://dx.doi.org/10.1259/bjr.20180890DOI Listing
April 2019
5 Reads

Low-Phospholipid Associated Cholelithiasis (LPAC) syndrome: A synthetic review.

J Visc Surg 2019 Mar 25. Epub 2019 Mar 25.

Service de chirurgie générale, digestive et transplantation hépatique et intestinale (general, digestive, liver transplant and intestinal surgery department), hôpital de la Croix Rousse, hospices civils de Lyon, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.

Low-Phospholipid Associated Cholelithiasis (LPAC) is a genetic disease responsible for the development of intrahepatic lithiasis. It is associated with a mutation of the ABCB4 gene which codes for protein MDR3, a biliary carrier. As a nosological entity, it is defined by presence of two of the three following criteria: age less than 40 years at onset of biliary symptoms, recurrence of biliary symptoms after cholecystectomy, and intrahepatic hyperechogenic foci detected by ultrasound. Read More

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http://dx.doi.org/10.1016/j.jviscsurg.2019.02.006DOI Listing
March 2019
1 Read

Effect of scheduled endoscopic dilatation of dominant strictures on outcome in patients with primary sclerosing cholangitis.

Gut 2019 Mar 25. Epub 2019 Mar 25.

Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany.

Objective: Scheduled endoscopic dilatation of dominant strictures (DS) in primary sclerosing cholangitis (PSC) might improve outcome relative to endoscopic treatment on demand, but evidence is limited. Since randomisation is difficult in clinical practice, we present a large retrospective study comparing scheduled versus on-demand endoscopic retrograde cholangiopancreatography (ERCP) based on patient preferences.

Design: Between 1987 and 2017, all new patients with PSC had been offered scheduled ERCP with dilatation of a DS if diagnosed; the latter was repeated at defined intervals until morphological resolution, independent of clinical symptoms (treatment group). Read More

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http://dx.doi.org/10.1136/gutjnl-2018-316801DOI Listing
March 2019
1 Read

Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice.

J Immunol Res 2019 14;2019:7657294. Epub 2019 Feb 14.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, Hebei, China.

Macrophages are the master regulator of the dynamic fibrogenesis-fibrosis resolution paradigm. TNF-like ligand 1 aberrance (TL1A) was found to be able to induce intestinal inflammation and fibrosis. Furthermore, significantly increased TL1A had been detected in liver tissues and mononuclear cells of patients with primary biliary cirrhosis (PBC). Read More

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https://www.hindawi.com/journals/jir/2019/7657294/
Publisher Site
http://dx.doi.org/10.1155/2019/7657294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393882PMC
February 2019
5 Reads

Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study.

Cancer Med 2019 Mar 22. Epub 2019 Mar 22.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.

Background: Previous studies have suggested an association between the use of direct-acting antiviral agents (DAAs) for treating hepatitis C virus (HCV) infection and the resulting decrease in the incidence of hepatocellular carcinoma (HCC); however, it is unclear whether DAAs prevent the recurrence of HCC after curative treatment for HCC. This study aimed to prospectively investigate HCC recurrence and its predictors after curative treatment for HCC.

Methods: A total of 3012 patients with chronic HCV infection, with or without cirrhosis, who were treated with DAAs were enrolled between January 1, 2015 and January 31, 2017 as per the institutional review board approved study protocol at 15 institutions, including 10 university hospitals and five high-volume centers in the Kyusyu area of Japan. Read More

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http://dx.doi.org/10.1002/cam4.2061DOI Listing
March 2019
2 Reads

Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium.

J Hepatol 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background & Aims: Congenital hepatic fibrosis (CHF) is a genetic liver disease with abnormal proliferation of cholangiocyte and progressive hepatic fibrosis. Mutation of polycystic kidney and hepatic disease 1 (PKHD1) causes CHF and the dysfunction of its coding protein, fibrocystin, is associated with ductal plate malformation during fetal development and further pathological changes in CHF patients. However, the underlying molecular mechanism of CHF remains unclear, which is quite different from liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.024DOI Listing
March 2019
8 Reads

Immunological abnormalities in patients with primary biliary cholangitis.

Clin Sci (Lond) 2019 Mar 19;133(6):741-760. Epub 2019 Mar 19.

College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi Province, China

Primary biliary cholangitis (PBC), an autoimmune liver disease occurring predominantly in women, is characterized by high titers of serum anti-mitochondrial antibodies (AMAs) and progressive intrahepatic cholestasis. The immune system plays a critical role in PBC pathogenesis and a variety of immune cell subsets have been shown to infiltrate the portal tract areas of patients with PBC. Amongst the participating immune cells, CD4 T cells are important cytokine-producing cells that foster an inflammatory microenvironment. Read More

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http://dx.doi.org/10.1042/CS20181123DOI Listing
March 2019
1 Read

Pharmacokinetics of Ursodeoxycholic Acid in Elderly Volunteers Compared With Younger Adults in a Korean Population.

J Clin Pharmacol 2019 Mar 18. Epub 2019 Mar 18.

Clinical Trials Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Ursodeoxycholic acid (UDCA) is a secondary bile acid component used for treating primary biliary cirrhosis. This study evaluated and compared the pharmacokinetic (PK) profiles of UDCA and its conjugates glyco-UDCA (G-UDCA) and tauro-UDCA (T-UDCA) in healthy elderly subjects and younger adults. In this randomized, open-label, 2-treatment, 1-sequence, and parallel study, subjects received 400 or 800 mg UDCA on day 1, followed by 200 mg UDCA twice daily for 2 weeks. Read More

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http://dx.doi.org/10.1002/jcph.1409DOI Listing

Intrahepatic diffuse periportal enhancement patterns on hepatobiliary phase gadoxetate disodium-enhanced liver MR images: Do they correspond to periportal hyperintense patterns on T2-weighted images?

Medicine (Baltimore) 2019 Mar;98(11):e14784

Institute for Clinical Radiology, Ludwig Maximilians-University Hospital Munich, Munich, Germany.

The purpose of this study was to investigate the findings of diffuse periportal enhancement in the liver on hepatobiliary phase gadoxetate disodium-enhanced magnetic resonance images by comparing with the finding of periportal hyperintensity on T2-weighted images and to reveal their clinical significance.Nineteen consecutive patients with diffuse periportal enhancement on hepatobiliary phase images constituted the study population. The intrahepatic diffuse periportal enhancement finding was assessed on whether it corresponded to periportal hyperintense patterns on T2-weighted images or not in the location, and the cases were classified into 2 groups according to this characteristic. Read More

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http://dx.doi.org/10.1097/MD.0000000000014784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426476PMC
March 2019
1 Read

Simple Magnetic Resonance Scores Associate With Outcomes of Patients With Primary Sclerosing Cholangitis.

Clin Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Assistance Publique - Hôpitaux de Paris, Sorbonne University, Department of Radiology, Saint-Antoine Hospital, Paris, France.

Background & Aims: Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in diagnosis of PSC. Magnetic resonance risk scoring systems, called Anali without and with gadolinium, are used to predict disease progression, determined by radiologic factors. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.03.013DOI Listing
March 2019
2 Reads

Senescent Hepatocytes in Decompensated Liver Show Reduced UPR and Its Key Player, CLPP, Attenuates Senescence In Vitro.

Cell Mol Gastroenterol Hepatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address:

Background And Aims: Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded protein response (UPR) helps in increasing longevity; however, its role in senescence and liver disease is poorly understood. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.03.001DOI Listing
March 2019
1 Read

[Immune-mediated cholangiopathies : Diagnostic and therapeutic challenges].

Authors:
T Herta U Beuers

Radiologe 2019 Apr;59(4):348-356

Department of Gastroenterology and Hepatology and Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location Academic Medical Center, AMC, C2-327, Meibergdreef 9, 1105 AZ, Amsterdam, Niederlande.

Background: Immune-mediated cholangiopathies comprise primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC). A common feature is the progressive destruction of bile ducts leading to cholestasis with fibrosis and cirrhosis of the liver over time. The diseases are mostly identified during routine laboratory testing. Read More

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http://dx.doi.org/10.1007/s00117-019-0513-xDOI Listing
April 2019
1 Read

Reply (to LTE HEP-19-0138).

Hepatology 2019 Mar 15. Epub 2019 Mar 15.

Department of Hepatology, Institute of Liver and Biliary Sciences(ILBS), New Delhi, India.

We thank Dr Habib for his interest in our study[1], and emphasizing the difficulties in diagnosing Autoimmune Hepatitis(AIH) in patients presenting with first acute decompensation with no known history of cirrhosis. Our study provides a much-needed criterion for diagnosing such patients. We agree ACLF term often includes a heterogeneous population and includes non-cirrhotics, compensated cirrhotics, previously decompensated cirrhotics, with or without liver failure, and sepsis[2]. Read More

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http://dx.doi.org/10.1002/hep.30614DOI Listing
March 2019
5 Reads

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

Sci Rep 2019 Mar 14;9(1):4530. Epub 2019 Mar 14.

Centre de Recherche du CHU de Québec - Université Laval, Département de microbiologie et immunologie, Faculté de Médecine de l'Université Laval, Québec, Qc, Canada.

Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. Read More

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http://dx.doi.org/10.1038/s41598-019-40900-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418244PMC
March 2019
1 Read

Endoscopic retrograde cholangiopancreatography (ERCP): lessons learned from population-based national registries: a systematic review.

Surg Endosc 2019 Mar 12. Epub 2019 Mar 12.

Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) was introduced more than four decades ago as a diagnostic tool for biliary and pancreatic diseases. Currently, ERCP is mainly used as a therapeutic approach to relieve biliary or pancreatic duct obstruction. Clinical practice has been based on a few large reports and some randomized controlled trials. Read More

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http://dx.doi.org/10.1007/s00464-019-06734-wDOI Listing
March 2019
3 Reads

Noninvasive Evaluation of Liver Fibrosis and Portal Hypertension After Successful Portoenterostomy for Biliary Atresia.

Hepatol Commun 2019 Mar 9;3(3):382-391. Epub 2019 Jan 9.

Pediatric Liver and Gut Research Group and Section of Pediatric Surgery Children's Hospital, Helsinki University Hospital Helsinki Finland.

We investigated noninvasive follow-up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow-up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly. Read More

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http://dx.doi.org/10.1002/hep4.1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396371PMC
March 2019
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Burden of Primary Biliary Cholangitis Among Inpatient Population in the United States.

Hepatol Commun 2019 Mar 28;3(3):356-364. Epub 2019 Jan 28.

Center for Liver Disease, Department of Medicine Inova Fairfax Hospital Falls Church VA.

Primary biliary cholangitis (PBC) is an autoimmune liver disease that can lead to cirrhosis and liver failure. Our aim was to assess the recent trends in the mortality rates and health care utilization of patients with PBC seen in the inpatient setting in the United States. We used the National (Nationwide) Inpatient Sample data (2005-2014). Read More

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http://dx.doi.org/10.1002/hep4.1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396368PMC
March 2019
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Identification of key challenges in liver pathology: data from a multicenter study of extramural consults.

Hum Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology, University of Washington Medical Center, Seattle, WA, USA.

Extramural consultation for challenging pathology cases is an important part of patient care. The specific reasons why liver cases are submitted in consultation are poorly understood. To study patterns in extramural consultation, data were gathered from 1360 liver/GI/pancreatobiliary consults submitted to 7 academic centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193003
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http://dx.doi.org/10.1016/j.humpath.2019.03.001DOI Listing
March 2019
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Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial.

Clin Mol Hepatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Hepatology and Liver Transplantation, Institute of Liver and Biliary Sciences, New Delhi, India.

Background/aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis.

Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks.

Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). Read More

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http://dx.doi.org/10.3350/cmh.2018.0084DOI Listing
March 2019
4 Reads

Diagnostic performance of a point shear wave elastography (pSWE) for hepatic fibrosis in patients with autoimmune liver disease.

PLoS One 2019 11;14(3):e0212771. Epub 2019 Mar 11.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.

Background & Aims: Elastography point quantification is a convenient method for measuring liver stiffness. It can be performed simultaneously with conventional ultrasonography. This study aimed to evaluate its diagnostic performance for assessing hepatic fibrosis in patients with autoimmune liver disease (AILD), including autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411150PMC
March 2019
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Role of Transplant in Biliary Disease.

Surg Clin North Am 2019 Apr;99(2):387-401

General Surgery, University of Alabama at Birmingham, 1808 7th Avenue South D202 Boshell Building Birmingham, Alabama 35233, USA; Division of Transplantation, University of Alabama at Birmingham, 701 19th Street South 722 Lyons Harrison Birmingham, Alabama 35233. Electronic address:

Orthotopic liver transplantation (OLT) has many roles in biliary disease. OLT provides excellent results for patients with unresectable hilar cholangiocarcinoma. OLT prolongs survival in primary biliary cirrhosis not responsive to therapy and improves quality of life. Read More

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http://dx.doi.org/10.1016/j.suc.2018.12.009DOI Listing
April 2019
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Autoimmune Diseases of the Biliary Tract: A Review.

Surg Clin North Am 2019 Apr 10;99(2):185-201. Epub 2019 Feb 10.

Division of Surgical Oncology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address:

The management of autoimmune hepatobiliary disorders remains a challenging and emerging area of investigation. An awareness of cholestatic liver diseases is critical to appropriate recognition and management of these challenging diseases, because patients often present asymptomatically, and diagnosis is limited by the lack of disease-specific markers and diagnostic studies. Furthermore, there is a paucity of treatment options because the pathophysiology underlying autoimmune biliary diseases remains largely unknown. Read More

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http://dx.doi.org/10.1016/j.suc.2018.11.003DOI Listing
April 2019
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Evaluation of Underlying Liver Disease and Its Severity in Children Referred for Liver Transplant: a Single-Center Report From Nemazee Hospital of Shiraz.

Exp Clin Transplant 2019 Mar 5. Epub 2019 Mar 5.

From the Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Liver transplant has been used as a curative approach for children with end-stage liver diseases. Here, we describe the underlying causes for pediatric liver transplant performed at the Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz, Iran.

Materials And Methods: In this cross-sectional des-criptive study, children < 18 years old who were candidates for liver transplant from 2007 to 2010 at the Shiraz Organ Transplantation Center were included. Read More

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http://dx.doi.org/10.6002/ect.2018.0047DOI Listing
March 2019
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Acquired cow's milk sensitization after liver transplant in an adult: "clinical implications" and future strategies.

Allergy Asthma Clin Immunol 2019 21;15:11. Epub 2019 Feb 21.

5Gastroenterology Unit, Department of Clinical Medicine, Sapienza University, Rome, Italy.

Background: Identifying the mechanisms responsible for the development of food allergy in liver transplant recipients is more complex as there are several different clinical scenarios related to the immunological function of the liver.

Case Presentation: We describe the first case of Transplant Acquired Food Allergy (TAFA) to cow milk in an adult following LT from a donor dead because of anaphylactic shock. A 67-year-old woman with primary biliary cirrhosis was referred to the Transplant Center of our hospital because of an acute-on-chronic liver failure. Read More

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http://dx.doi.org/10.1186/s13223-019-0326-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385433PMC
February 2019
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Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study.

Hepatol Int 2019 Feb 28. Epub 2019 Feb 28.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: While achieving sustained virological response (SVR) following interferon-based or direct-acting antiviral agent (DAA) treatments reduces the incidence of hepatocellular carcinoma (HCC), an increase in unexpected early occurrence or recurrence of HCC after hepatitis C virus elimination by DAA treatments has been reported. We prospectively investigated the incidence and risk factors of HCC after DAA treatment in a large multicenter cohort in Japan.

Methods: Patients with chronic hepatitis C with or without cirrhosis who were treated with DAAs and obtained SVR were enrolled. Read More

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http://dx.doi.org/10.1007/s12072-019-09939-2DOI Listing
February 2019
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Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma: Does the Degree of Ethiodized Oil Accumulation within the Tumor Affect the Therapeutic Efficacy?

J Vasc Interv Radiol 2019 03;30(3):370-379.e4

Department of Radiology, Chosun University Hospital and Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Republic of Korea.

Purpose: To evaluate the effects of the degree of ethiodized oil accumulation achieved by transarterial chemoembolization followed by radiofrequency (RF) ablation on the treatment efficacy for a single intermediate-sized hepatocellular carcinoma (HCC).

Materials And Methods: A total of 153 consecutive patients who underwent chemoembolization and RF ablation for a single intermediate-sized HCC (2-5 cm) were included. On the basis of the degree of ethiodized oil accumulation in HCC on cone-beam CT images, patients who underwent chemoembolization and RF ablation were classified into 2 groups: compact accumulation (≥ 75%) and noncompact accumulation (< 75%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10510443183149
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http://dx.doi.org/10.1016/j.jvir.2018.09.009DOI Listing
March 2019
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Molecular Pathogenesis of Cholangiocarcinoma.

BMC Cancer 2019 Feb 28;19(1):185. Epub 2019 Feb 28.

UCL Institute for Liver and Digestive Health, University College London (Royal Free Hospital Campus), Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

Background: Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. Read More

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http://dx.doi.org/10.1186/s12885-019-5391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394015PMC
February 2019
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Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report.

BMC Gastroenterol 2019 Feb 28;19(1):37. Epub 2019 Feb 28.

Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of the lack of an endoscopic banding ligation device for pediatric patients, EIS is usually performed for bleeding esophageal varices (EV) in infants with congenital biliary atresia.

Case Presentation: We present a case of a 15-month-old female infant with type I biliary atresia with jaundice (total serum bilirubin, 22. Read More

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http://dx.doi.org/10.1186/s12876-019-0955-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396477PMC
February 2019
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Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis.

Aliment Pharmacol Ther 2019 Mar;49(6):779-788

Departmentof Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Increasing evidence suggests that coffee consumption might protect against hepatocellular carcinoma (HCC) and liver cirrhosis-associated death risk. Caffeine is a natural antagonist to extracellular adenosine and exhibits experimental tumoricidal activity.

Aim: To evaluate if coffee consumption has beneficial effects on HCC recurrence after orthotopic liver transplantation (OLT). Read More

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http://dx.doi.org/10.1111/apt.15089DOI Listing
March 2019
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Correlation between hepatic oxidative damage and clinical severity and mitochondrial gene sequencing results in biliary atresia.

Hepatol Res 2019 Feb 27. Epub 2019 Feb 27.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.

Aim: To assess the level of hepatic oxidative damage and its correlation with clinical severity in biliary atresia (BA), and to understand BA mitochondrial gene sequencing.

Methods: Forty-eight BA patients and 28 control subjects (20 hepatoblastoma and 8 cholestasis patients) were enrolled. Hepatic oxidative damage was assessed by the expression of oxidation and antioxidant genes, and the correlation between oxidative damage and BA incidence, liver inflammation, and fibrosis was evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13324DOI Listing
February 2019
3 Reads