14,139 results match your criteria Primary Biliary Cirrhosis


[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019

Results of Sofosbuvir Plus Ribavirin in Patients With Hepatitis C Related Decompensated Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):4-12. Epub 2018 Mar 6.

Institute of Liver, Gastroenterology, & Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, India.

Background: Sofosbuvir (SOF), a direct acting antiviral, has revolutionized the treatment of chronic Hepatitis C Virus (HCV) infection. However, data is scarce about efficacy of SOF plus Ribavarin (RBV) in Indian patients with decompensated cirrhosis. We evaluated the efficacy of SOF plus RBV in decompensated cirrhosis, and compared the outcome with compensated cirrhosis and non-cirrhotics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183004
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http://dx.doi.org/10.1016/j.jceh.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363947PMC
March 2018
2 Reads

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological tumorigenic potential of RNs is still unclear. To uncover the molecular bases of tumorigenesis in liver cirrhosis, we investigated the genetic aberrations in RNs of cirrhotic tissues using next-generation sequencing. Read More

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http://dx.doi.org/10.1007/s00535-019-01555-zDOI Listing
February 2019
1 Read

Roux-en-Y Gastric Bypass Reversal for Severe Malnutrition and Cirrhosis.

Obes Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Digestive and Metabolic Surgery, Avicenne University Hospital, Centre intégré Nord Francilien de la prise en charge de l'Obésité (CINFO), Université Paris XIII-UFR SMBH « Léonard de Vinci », 125 route de Stalingrad, 93000, Bobigny, France.

Background: Severe post-operative malnutrition (SM) is a dreaded complication after gastric bypass often related to the short bowel syndrome consecutive limb length mismeasurement or intestinal resections. Patients with rapid weight loss or malnutrition can experience liver failure with cirrhosis and require liver transplantation (LT). Malnutrition can constitute a contraindication to LT since it negatively impacts on postoperative morbidity. Read More

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http://dx.doi.org/10.1007/s11695-019-03770-2DOI Listing
February 2019

Bone Health in Patients With Liver Diseases.

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

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http://dx.doi.org/10.1016/j.jocd.2019.01.004DOI Listing
January 2019
1 Read

Impact of a Multidisciplinary Team on Alcohol Recidivism and Survival After Liver Transplant for Alcoholic Disease.

Transplant Proc 2019 Jan - Feb;51(1):187-189. Epub 2018 Jun 30.

Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: Alcohol use disorders have a prevalence of 10% among the population of the United States and Europe and are one of the most frequent causes of liver cirrhosis in the Western world. Currently, alcohol-related liver cirrhosis represents one of the most frequent indications to liver transplant (LT), both as independent cause or associated with hepatitis C virus or hepatitis B virus infections. Starting from 2014, a multidisciplinary team involving surgeons, gastroenterologists, clinical toxicologists, psychiatrists, and psychologists was developed within the Modena Liver Transplant Center. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.212DOI Listing
June 2018
1 Read

Long-term results of secondary biliary repair for cholecystectomy-related bile duct injury: results of a tertiary referral center.

Acta Chir Belg 2019 Feb 7:1-10. Epub 2019 Feb 7.

a Department of Abdominal Surgery and Transplantation , Cliniques universitaires Saint-Luc , Brussels , Belgium.

Background: Management of bile duct injury (BDI) after cholecystectomy is challenging. The authors analyzed their center's 49-year experience.

Methods: From 1968 to 2016, 120 consecutive patients were managed in a tertiary HBP center, 105 referred from other centers (Group A), 15 from our center (Group B). Read More

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http://dx.doi.org/10.1080/00015458.2019.1570741DOI Listing
February 2019
1 Read

Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

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http://dx.doi.org/10.1007/s10620-019-05484-yDOI Listing
February 2019
1 Read

Effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in adults with cirrhosis: a protocol for a systematic review.

BMJ Open 2019 Jan 29;9(1):e025664. Epub 2019 Jan 29.

Division of Medicine, University College London, London, UK.

Introduction: Use of albumin therapy is recommended for management of disease complications in cirrhosis. The effectiveness of albumin to prevent specific disease complications and death, however, is less clear.

Methods And Analysis: We will search Medline (Ovid), Embase (Ovid), Cochrane Hepato-Biliary Controlled Trials Register and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in cirrhotic patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025664DOI Listing
January 2019
1 Read

Chinese consensus on the clinical application of hepatobiliary MR imaging contrast agent - Gd-EOB-DTPA.

J Dig Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Medical Imaging Institute, Shanghai, China.

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) helps improve the ability of detection and diagnosis of focal hepatic lesions, especially for evaluating smaller lesions (<1 cm in diameter) and the diseases of the biliary system. MRI-based function tests with Gd-EOB-DTPA have gained immense popularity in recent years as it can be integrated into clinical setup with a higher temporal and spatial resolution and without ionizing radiation. Gd-EOB-DTPA has been in use since 2011 in China. Read More

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http://dx.doi.org/10.1111/1751-2980.12707DOI Listing
January 2019
5 Reads

The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders.

Curr Health Sci J 2018 Apr-Jun;44(2):186-191. Epub 2018 Mar 27.

University of Oradea, Faculty of Medicine and Pharmacy.

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320469PMC
March 2018
10 Reads

[Research progress on risk factors for poor response of ursodeoxycholic acid in primary biliary cholangitis].

Authors:
Z Yuan G Jia Y Han

Zhonghua Gan Zang Bing Za Zhi 2019 Jan;27(1):73-76

Department of Digestive Disease, Xijing Hospital, the Military Medical University of Air Force PLA, Xi'an 710032, China.

Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease. Ursodeoxycholic acid (UDCA) is a first-line drug approved by the Food and Drug Administration for the treatment of PBC. It can effectively improve serum biochemical indicators, delay histological progress, and prolong the survival of non-transplant patients. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.01.018DOI Listing
January 2019
2 Reads

The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor.

J Control Release 2019 Feb 22;296:250-257. Epub 2019 Jan 22.

Groningen Research Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands. Electronic address:

Rho kinase activity in hepatic stellate cells (HSCs) is associated with activation, transformation and contraction of these cells, leading to extracellular matrix production and portal hypertension in liver cirrhosis. Inhibition of rho kinase activity can reduce these activities, but may also lead to side effects, for instance systemic hypotension. This can be circumvented by liver-specific delivery of a rho kinase inhibitor to effector cells. Read More

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http://dx.doi.org/10.1016/j.jconrel.2018.12.039DOI Listing
February 2019
2 Reads

Functional SNPs in the Human Autoimmunity-Associated Locus 17q12-21.

Genes (Basel) 2019 Jan 23;10(2). Epub 2019 Jan 23.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Genome-wide association studies (GWASes) revealed several single-nucleotide polymorphisms (SNPs) in the human 17q12-21 locus associated with autoimmune diseases. However, follow-up studies are still needed to identify causative SNPs directly mediating autoimmune risk in the locus. We have chosen six SNPs in high linkage disequilibrium with the GWAS hits that showed the strongest evidence of causality according to association pattern and epigenetic data and assessed their functionality in a local genomic context using luciferase reporter system. Read More

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http://dx.doi.org/10.3390/genes10020077DOI Listing
January 2019

Pediatric living donor liver transplant in a recipient with biliary atresia and portal vein duplication-How did we manage it?

Pediatr Transplant 2019 Jan 24:e13356. Epub 2019 Jan 24.

Unidad de Trasplante Hepático, Hospital Universitario Fundación Favaloro, Buenos Aires, Argentina.

Portal vein malformations might occur during the embryonic period, as a consequence of abnormal remodeling of vitelline veins during embryonic life. Patients suffering from biliary atresia are particularly prone to have vascular malformations; although being the most frequent indication for liver transplantation in the pediatric age, portal vein duplication has not been so far associated with biliary atresia, and to the best of our knowledge, there is no-written evidence describing how to manage it when it is first diagnosed while performing a pediatric liver transplant. Therefore, we present a recent case from our group, describing the intraoperative diagnosis of a double portal system in a patient with biliary atresia and failed Kasai. Read More

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http://dx.doi.org/10.1111/petr.13356DOI Listing
January 2019
2 Reads

Predisposing Conditions to Pediatric Hepatocellular Carcinoma and Association with Outcomes: Single-Center Experience.

J Pediatr Gastroenterol Nutr 2019 Jan 21. Epub 2019 Jan 21.

Pediatrics- Gastroenterology, Baylor College of Medicine.

Objectives: Hepatocellular carcinoma (HCC) has been linked to chronic viral or metabolic liver disease and other conditions. The characteristics of children with HCC have not been fully elucidated and outcomes in children with predisposing liver disease are not well defined.

Methods: Patients ≤ 21 years old with HCC managed at our institution and through external consultation between 1996 and 2016 were included. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002285DOI Listing
January 2019
4 Reads

The Autoimmune Susceptibility Gene Regulates Macrophage-Mediated Resolution of Inflammation.

J Immunol 2019 Feb 18;202(4):1069-1078. Epub 2019 Jan 18.

University College Dublin Centre for Arthritis Research, Conway Institute, University College Dublin, Dublin D04 W6F6, Ireland.

Genetic variants in have been associated with development of the autoimmune conditions primary biliary cirrhosis and rheumatoid arthritis. In rheumatoid arthritis, C5orf30 expression is cell-specific, with highest expression found in macrophages and synovial fibroblasts. C5orf30 is highly expressed in inflamed joints and is a negative regulator of tissue damage in a mouse model of inflammatory arthritis. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801155
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http://dx.doi.org/10.4049/jimmunol.1801155DOI Listing
February 2019
6 Reads

Pneumocystis jirovecii-related spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in a liver transplant recipient: a case report.

BMC Infect Dis 2019 Jan 18;19(1):66. Epub 2019 Jan 18.

Department of Surgery, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China.

Background: Pneumocystis pneumonia (PCP) is a common opportunistic infection caused by Pneumocystis jirovecii. Its incidence at 2 years or more after liver transplant (LT) is < 0.1%. Read More

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http://dx.doi.org/10.1186/s12879-019-3723-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339407PMC
January 2019
2 Reads

Primary Prophylaxis for Gastrointestinal Bleeding in Children With Biliary Atresia and Portal Hypertension Candidates for Liver Transplantation: A Single-Center Experience.

Transplant Proc 2019 Jan - Feb;51(1):171-178. Epub 2018 Jun 28.

Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children's Research Hospital IRCCS, Rome, Italy.

Background: Cirrhosis for biliary atresia (BA) is associated with risk of gastrointestinal bleeding (GB) from gastroesophageal varices due to portal hypertension. Primary prophylaxis of GB is controversial in children who are candidates for liver transplantation (LT). The aim of the study was to define the management of gastroesophageal varices and to identify the benefit of primary prophylaxis for GB in BA children waiting for LT. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.074DOI Listing
June 2018
2 Reads

NUF2 is a valuable prognostic biomarker to predict early recurrence of hepatocellular carcinoma after surgical resection.

Int J Cancer 2019 Jan 17. Epub 2019 Jan 17.

Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.

Early tumor recurrence after curative surgical resection poses a great challenge to the clinical management of hepatocellular carcinoma (HCC). We conducted whole genome expression microarrays on 64 primary HCC tumors with clinically defined recurrence status and cross-referenced with RNA-seq data from 18 HCC tumors in the Cancer Genome Atlas project. We identified a 77-gene signature, which is significantly associated with early recurrent (ER) HCC tumors. Read More

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http://dx.doi.org/10.1002/ijc.32134DOI Listing
January 2019
1 Read

[Endoscopic and surgical treatment of chronic pancreatitis].

Internist (Berl) 2019 Jan 11. Epub 2019 Jan 11.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 München, Deutschland.

With an increasing number of hospital admissions, an average of 16-to 20 days in hospital per year, 34% of patients constantly taking pain medication, 57% in need of enzyme supplementation, and 29% with diabetes mellitus, chronic pancreatitis is a debilitating disease of high socio-economic relevance. In total, 33% of all patients suffering from chronic pancreatitis can no longer practice their original profession. The number of unemployed chronic pancreatitis patients due to prolonged stays in hospital or continued alcohol abuse is known to be as high as 40%. Read More

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http://dx.doi.org/10.1007/s00108-018-0546-7DOI Listing
January 2019
3 Reads

Efficacy and safety of Yinchen Sini decoction in treating biliary atresia patients after Kasai portoenterostomy: A systematic review and meta-analysis protocol.

Medicine (Baltimore) 2019 Jan;98(2):e13935

Department of paediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Biliary atresia (BA) is a neonatal obstructive biliary tract disease in which the intrahepatic and extrahepatic bile ducts are obstructed and can lead to congenital biliary atresia of cholestatic cirrhosis and eventually liver failure. It has been confirmed that the Kasai portoenterostomy is an effective treatment for BA. But most patients still face complications, such as cholangitis and liver fibrosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336556PMC
January 2019
2 Reads

Treatment of Fatigue in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.

Dig Dis Sci 2019 Jan 10. Epub 2019 Jan 10.

Liver Center, Autoimmune and Cholestatic Liver Disease Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

Background And Aims: Fatigue is the most common complication of primary biliary cholangitis (PBC) and can be debilitating. Numerous interventions have been trialed targeting several proposed mechanisms of PBC-associated fatigue. We sought to summarize and perform a meta-analysis to determine the efficacy of these interventions. Read More

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http://link.springer.com/10.1007/s10620-019-5457-5
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http://dx.doi.org/10.1007/s10620-019-5457-5DOI Listing
January 2019
12 Reads

[Clinical and pathological characteristics and outcome of 46 children with autoimmune hepatitis].

Zhonghua Er Ke Za Zhi 2019 Jan;57(1):40-45

Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of the People's Liberation Army (PLA), Beijing 100039, China.

To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.01.010DOI Listing
January 2019
3 Reads

Current therapies and novel approaches for biliary diseases.

World J Gastrointest Pathophysiol 2019 Jan;10(1):1-10

Department of Medicine, The University of Melbourne, Melbourne, VIC 3084, Australia.

Chronic liver diseases that inevitably lead to hepatic fibrosis, cirrhosis and/or hepatocellular carcinoma have become a major cause of illness and death worldwide. Among them, cholangiopathies or cholestatic liver diseases comprise a large group of conditions in which injury is primarily focused on the biliary system. These include congenital diseases (such as biliary atresia and cystic fibrosis), acquired diseases (such as primary sclerosing cholangitis and primary biliary cirrhosis), and those that arise from secondary damage to the biliary tree from obstruction, cholangitis or ischaemia. Read More

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https://www.wjgnet.com/2150-5330/full/v10/i1/1.htm
Publisher Site
http://dx.doi.org/10.4291/wjgp.v10.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318481PMC
January 2019
3 Reads

Cholecystectomy during esophagectomy is safe but unnecessary.

Acta Chir Belg 2019 Jan 8:1-7. Epub 2019 Jan 8.

e Department of upper GI surgery , Humanitas Research Hospital - Humanitas University , Rozzano (Milano) , Italy.

Background: Prophylactic cholecystectomy has been proposed as a concomitant procedure during upper gastrointestinal surgery. This study evaluates the safety and the need of concurrent cholecystectomy during esophagectomy for cancer.

Methods: All consecutive esophagectomies for esophageal cancer at the Center for Esophageal Diseases in Padova (Italy) between 1992 and 2011 were included. Read More

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http://dx.doi.org/10.1080/00015458.2018.1554364DOI Listing
January 2019
2 Reads
0.440 Impact Factor

[Staging of liver fibrosis in biliary atresia : Comparison of Chevallier and Ishak score as well as automated evaluation].

Pathologe 2019 Feb;40(1):85-92

Zentrum für Kinderchirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Background: Biliary atresia (BA) is a rare disease of the newborn, resulting in liver cirrhosis due to obliterative cholangiopathy. Liver biopsies are commonly performed in order to confirm the diagnosis and in order to stage fibrosis.

Objectives: The present study intended to analyze two established scores for evaluating liver fibrosis focusing on the interobserver variability as well as the prognostic reliability towards the time of liver transplantation. Read More

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http://dx.doi.org/10.1007/s00292-018-0558-zDOI Listing
February 2019

Pediatric Living-Donor Liver Transplant Recipients without Transition After Reaching Adulthood.

Ann Transplant 2019 Jan 8;24:18-24. Epub 2019 Jan 8.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

BACKGROUND Transition to adult care can trigger certain problems for pediatric liver transplant recipients. At our institution, the same transplant team performs both adult and pediatric liver transplantation and post-transplant care; thus, pediatric liver transplant recipients do not have to be transferred. However, it is unclear whether this system affects the recipient's outcome during the transition period. Read More

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http://dx.doi.org/10.12659/AOT.911544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338013PMC
January 2019

Acetyl-L-carnitine for patients with hepatic encephalopathy.

Cochrane Database Syst Rev 2019 01 5;1:CD011451. Epub 2019 Jan 5.

Iberoamerican Cochrane Network, Valencia, Venezuela.

Background: Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease. Ammonia content in the blood seems to play a role in the development of hepatic encephalopathy. Treatment for hepatic encephalopathy is complex. Read More

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http://dx.doi.org/10.1002/14651858.CD011451.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353234PMC
January 2019
2 Reads

Red blood cell transfusion in liver resection.

Langenbecks Arch Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Several modalities exist for the management of hepatic neoplasms. Resection, the most effective approach, carries significant risk of hemorrhage. Blood loss may be corrected with red blood cell transfusion (RBCT) in the short term, but may ultimately contribute to negative outcomes. Read More

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http://dx.doi.org/10.1007/s00423-018-1746-2DOI Listing
January 2019
2 Reads

IL-22 in hepatocyte's survival of Pakistani patients with end stage liver disease: an insight into IL 22 mediated hepato-regenerative pathway.

Mol Biol Rep 2019 Jan 2. Epub 2019 Jan 2.

Department of Histopathology, Shaikh Zayed Hospital, Lahore, 54000, Punjab, Pakistan.

Hepatitis is the principal cause of hepatocellular carcinoma (HCC) and decompensated cirrhosis. HCC is amongst the leading causes of deaths worldwide. Current therapeutic options have proven to be unsuccessful in treating this disease due to multifactorial nature of the disease. Read More

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http://dx.doi.org/10.1007/s11033-018-04573-xDOI Listing
January 2019
1 Read
2.024 Impact Factor

Natural Course and Risk of Cholangiocarcinoma in Patients with Recurrent Pyogenic Cholangitis: A Retrospective Cohort Study.

Gut Liver 2018 Dec 19. Epub 2018 Dec 19.

Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Background/aims: Recurrent pyogenic cholangitis (RPC) is a chronic, progressive disease frequently accompanied by cholangiocarcinoma (CCA). This study aimed to investigate the natural course of RPC and identify factors associated with CCA.

Methods: From January 2005 to December 2016, 310 patients with RPC at Seoul National University Hospital were included. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
Publisher Site
http://dx.doi.org/10.5009/gnl18339DOI Listing
December 2018
4 Reads

Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation.

Pediatr Transplant 2018 Dec 30:e13339. Epub 2018 Dec 30.

Paediatric Liver, Gastroenterology and Nutrition Centre, King's College Hospital, London, UK.

Objectives: Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ACLF and outcomes in children with BA while awaiting deceased donor LT. Read More

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http://dx.doi.org/10.1111/petr.13339DOI Listing
December 2018
7 Reads

Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030?

PLoS One 2018 31;13(12):e0209374. Epub 2018 Dec 31.

Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Genève, Switzerland.

Catalyzed by the concerns over the growing public health and economic burden of Hepatitis C virus (HCV) in Switzerland, a diverse group of experts and patient representatives came together in 2014 to develop the Swiss Hepatitis Strategy, setting targets for the elimination of viral hepatitis in Switzerland by 2030. Previous studies have reported the estimated number of chronic HCV infections and forecasted burden of disease given different intervention strategies. However, given new prevalence data by the Swiss Federal Office of Public Health, which decreased total infections by about half, an updated analysis is warranted. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209374PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312389PMC
December 2018
5 Reads

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

Ann Hepatol 2018 Dec;18(1):215-219

Liver Unit, Internal Medicine Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

IgG4-related disease is a recently-described fibro-inflammatory condition with characteristic histopathological findings in the organs involved. The most commonly affected organs are pancreas, lymph nodes, and retroperitoneum. Liver disease usually involves bile structures and therefore IgG4-related disease is considered a cause of secondary sclerosing cholangitis. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7916DOI Listing
December 2018
1 Read

Acoustic Radiation Force Impulse (ARFI) Elastography in Autoimmune and Cholestatic Liver Diseases.

Ann Hepatol 2018 Dec;18(1):23-29

Department of Internal Medicine 1, Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany.

Introduction: Acoustic Radiation Force Impulse (ARFI) elastography evaluates hepatic fibrosis non-invasively and has been mainly validated in viral hepatitis. Data on rare liver diseases such as autoimmune hepatitis (AIH), overlap syndrome, primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) are sparse.

Material And Methods: 85 patients (including 31 AIH, 26 PBC, 16 PSC and 3 PSC- and 9 PBC- AIH-overlap syndromes) were retrospectively analysed pointing at ARFI elastography of the liver and the correlation with histologic Ishak fibrosis score (F0-6). Read More

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http://dx.doi.org/10.5604/01.3001.0012.7858DOI Listing
December 2018
1 Read

Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00185, Rome, Italy. Electronic address:

Background: Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy.

Aims: To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.008DOI Listing
November 2018
7 Reads

[PRIMARY BILIARY CHOLANGITIS: THERAPEUTIC APPROACH IN THE MODERN ERA].

Harefuah 2018 Dec;157(12):791-796

Gastroenterology Institute, Hillel Yaffe Medical Center, affiliated to the Ruth and Rappaport Faculty of Medicine, Haifa, Israel.

Introduction: Primary biliary cholangitis (PBC) is a progressive, autoimmune cholestatic liver disease, predominantly affecting middle-aged women. Hallmark features include a persistent elevation of cholestatic liver enzymes, presence of anti-mitochondrial antibodies and characteristic histologic findings. PBC has a varied course of progression, ranging from mild uncomplicated disease to aggressive disease leading to cirrhosis and resulting in the need for liver transplantation. Read More

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December 2018
6 Reads

Idiopathic inflammatory myopathies with anti-mitochondrial antibodies: Clinical features and treatment outcomes in a Chinese cohort.

Neuromuscul Disord 2019 Jan 22;29(1):5-13. Epub 2018 Nov 22.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, China; Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Shandong University, Qingdao, China; Brain Science Research Institute, Shandong University, Jinan, China. Electronic address:

Anti-mitochondrial antibodies, the hallmark of primary biliary cirrhosis, have been detected in many patients with idiopathic inflammatory myopathies and these anti-mitochondrial-antibody-associated idiopathic inflammatory myopathies frequently show unique characteristics. We detected anti-mitochondrial antibodies in Chinese idiopathic inflammatory myopathy and summarized the clinical findings of these anti-mitochondrial-antibody-positive patients. Of 136 patients, seven (5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608966173148
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http://dx.doi.org/10.1016/j.nmd.2018.11.004DOI Listing
January 2019
3 Reads
2.638 Impact Factor

Mild to Moderate Intrapulmonary Shunting in Pediatric Liver Transplantation: Is Screening Necessary?

Transplant Proc 2018 Dec 30;50(10):3496-3500. Epub 2018 May 30.

Organ Transplantation Centre, National Centre for Child Health and Development, Tokyo, Japan.

Background: Despite reported associations between intrapulmonary vascular shunting (IPVS) and morbidity and mortality in pediatric liver transplantation (LT), there are no guidelines for screening.

Objective: To investigate IPVS before and after pediatric LT.

Methods: Retrospective records review of all pediatric LT (n = 370) from 2005 to 2015 at a single institute in Japan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183073
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http://dx.doi.org/10.1016/j.transproceed.2018.05.025DOI Listing
December 2018
3 Reads

Physical exercise for people with cirrhosis.

Cochrane Database Syst Rev 2018 12 21;12:CD012678. Epub 2018 Dec 21.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus, 8200 N, Denmark.

Background: Loss of muscle mass and muscle weakness are common complications to cirrhosis and are associated with increased morbidity and mortality. Therefore, physical exercise may benefit people with cirrhosis.

Objectives: To assess the beneficial and harmful effects of physical exercise versus sham exercise or no exercise for people with cirrhosis. Read More

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http://dx.doi.org/10.1002/14651858.CD012678.pub2DOI Listing
December 2018
1 Read

Past hepatitis B virus infection was not associated with poorer response or the UK-PBC risk score in ursodeoxycholic acid-treated patients with primary biliary cirrhosis.

Eur J Gastroenterol Hepatol 2019 02;31(2):277

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

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http://dx.doi.org/10.1097/MEG.0000000000001320DOI Listing
February 2019
1 Read
2.152 Impact Factor

Haemostatic radiation therapy for a bleeding intraductal papillary neoplasm of the biliary tree.

BMJ Case Rep 2018 Dec 14;11(1). Epub 2018 Dec 14.

Department of Hepatopancreaticobiliary Surgery, Christian Medical College and Hospital, Vellore, Tamil nadu, India.

Haemostatic radiation was effectively used as a novel rescue therapy in a 60-year-old man who presented with recurrent melaena refractory to all conventional medical and surgical measures. He needed multiple transfusions and was diagnosed to be bleeding from an intraductal papillary biliary neoplasm which was not amenable to surgical resection in view of the background liver disease. He received conventional radiation therapy (RT) of a dose of 3 Gy per fraction for 3 consecutive days after which he stabilised. Read More

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http://dx.doi.org/10.1136/bcr-2018-226237DOI Listing
December 2018

Indocyanine green fluorescence image-guided total laparoscopic living donor right hepatectomy: The first case report from Mainland China.

Int J Surg Case Rep 2018 22;53:406-409. Epub 2018 Nov 22.

Department of Hepatobiliary Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, Beijing, 100853, China. Electronic address:

Introduction: Total laparoscopic living donor right hepatectomy (TLDRH) is sporadically reported worldwide. Liver transection margin used to be determined by ischemic demarcation or intraoperative ultrasonography. To identify the site of bile duct division relied on preoperative MRCP and intraoperative cholangiography, which is experience demanding. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260439PMC
November 2018

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183540
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http://dx.doi.org/10.1053/j.gastro.2018.12.005DOI Listing
December 2018
11 Reads
16.716 Impact Factor

The metabolic signature of Primary Biliary Cholangitis and its comparison with Coeliac Disease.

J Proteome Res 2018 Dec 12. Epub 2018 Dec 12.

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by ongoing inflammatory destruction of the interlobular bile ducts, eventually leading to chronic cholestasis and biliary cirrhosis. This study primarily aims to define the metabolomic signature of PBC after comparison with healthy controls (HC). Secondly it aims at evaluating the possible metabolic association between PBC and coeliac disease (CD), an immune-mediated disorder frequently associated with PBC. Read More

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00849
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http://dx.doi.org/10.1021/acs.jproteome.8b00849DOI Listing
December 2018
12 Reads

APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment?

Hepatol Int 2018 Dec 11. Epub 2018 Dec 11.

Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu-shi, Yamanashi, 400-8506, Japan.

Chronic hepatitis C virus (HCV) infection is common among patients with chronic kidney disease (CKD) and those on hemodialysis due to nosocomial infections and past blood transfusions. While a majority of HCV-infected patients with end-stage renal disease are asymptomatic, some may ultimately experience decompensated liver diseases and hepatocellular carcinoma. Administration of a combination of elbasvir/grazoprevir for 12 weeks leads to high sustained virologic response (SVR) rates in patients with HCV genotypes (GTs) 1a, 1b or 4 and stage 4 or 5 CKD. Read More

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http://dx.doi.org/10.1007/s12072-018-9915-5DOI Listing
December 2018
2.468 Impact Factor