676 results match your criteria Prilozi Contributions [Journal]


Hyperfibrinogenemia in Peripheral Arterial Disease: Coexistent and Independent Risk Factor (A Report of Two Cases and Review of Literature).

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):93-96

Institute for Public Health of R. Macedonia, Skopje, Republic of Macedonia.

These case reports aim to show that hyperfibrinogenemia is a risk factor for the progression and prognosis of peripheral arterial disease (PAD), in patients with and without diabetes mellitus type 2. We present a patient with PAD who has type 2 diabetes mellitus, who has previously been repeatedly treated for lower limb ischemia with multiple vascular surgeries performed. A few weeks before admission the patient developed critical lower limb ischemia, which was treated with an iliaco-popliteal and femorofemoral bypass. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0046DOI Listing
December 2018
1 Read

Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):63-68

University Children's Hospital, Medical Faculty Skopje, Republic of Macedonia.

Introduction: The term angiodysplasia (AD) refers to acquired malformation of the blood vessels (communications between veins and capillaries), frequently found within the gastrointestinal mucosa and submucosa. AD of stomach and duodenum are cause of upper gastrointestinal bleeding in 4%-7% of patients. The means of treatment are usually endoscopic, including argon plasma coagulation (APC), electrocoagulation, mechanical hemostasis by clippsing, laser photo-coagulation and injection therapy. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0043DOI Listing
December 2018
3 Reads

A 4-Year-Old Boy with Beckwith Wiedemann Syndrome (BWS).

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):131-135

Center for Human Genetics, Bioscientia Institute for Medical Diagnostics Ingelheim, Germany.

Objectives: Molecular characterization of a patient with BWS.

Clinical Presentation And Intervention: A 4-year-old boy with overgrowth (weight above 99th and height at 99th percentile) had longitudinal hemihypertrophy of the tongue and left cheek. In addition, there was a difference of one centimeter in the circumference of the left and right leg. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0052DOI Listing
December 2018

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):21-28

Institute of Pathology, Faculty of Medicine, Skopje, Republic of Macedonia.

Introduction: Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data.

Material And Methods: We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0038DOI Listing
December 2018
3 Reads

Nutritional Assessment of Dialysis Patient with a Web-Based Tool Allows More Accurate Treatment of Malnutrition.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):37-43

Dialysis Department, University Clinical Centre of Ljubljana, Slovenia.

Background/aims: Regular assessment of nutritional status of dialysis patients is vital for preventing malnutrition and protein energy wasting. The aim of this clinical study was to analyze dietary intake of dialysis patients and to determine if it meets their nutritional needs.

Methods: Clinical study was conducted on 30 randomly selected dialysis patients in the dialysis department of the University Medical Centre Ljubljana. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0040DOI Listing
December 2018
6 Reads

Evaluation of Correlation Between the Pharmacogenetic Profiles of Risperidone Treated Psychiatry Patients with Plasma and Urine Concentration of Risperidone and its Active Moiety 9-OH Risperidone Determined with Optimized Bioanalytical LC Method.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):97-106

University Clinic of Psychiatry, Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, Republic of Macedonia.

Atypical antipsychotic risperidone is widely used first-line monotherapy in schizophrenia and combined therapy in bipolar disorders. Therapeutic plasma concentrations of risperidone and its active moiety are directly influenced by genetic variations in metabolic CYP450 enzymes (CYP2D6 and CYP3A4/5) and transporter (ABCB1) protein and additional environmental factors. Since active metabolite 9-OH risperidone has a greater percentage of the pharmacologically active fraction and is equipotent to the parent drug risperidone, it is assumed that it contributes significantly to therapeutic and adverse effects. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0047DOI Listing
December 2018
2 Reads

Epidemiological Analysis and Geographical Distribution of Patients Suffering from Rheumatoid Arthritis, Eligible for First-Line Therapy/Monotherapy Treatment with Subcutaneous Formulation of Tocilizumab in the Republic of Macedonia.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):69-78

Roche Macedonia DOOELSkopje, Republic of Macedonia.

Rheumatoid arthritis is an inflammatory arthritis characterized by synovial tissue inflammation that leads to structural damage and disability. There are several treatment options available, which include glucocorticoids, DMARDs and biologics given alone as monotherapy or in a variety of combinations. Recent evidence has shown that early treatment is important in reducing the rate of progression of erosions and decreasing disability. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0044DOI Listing
December 2018
4 Reads

ICGEB Workshop on Next Generation Diagnostics, 22/03/2018-24/03/2018, Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):137-142

Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.

More than 200 participants from Europe, Asia, Africa and South America attended the two days ICGEB Workshop on Next Generation Diagnostics, 22/03/2018-24/03/2018, at the Macedonian Academy of Sciences and Arts (MASA) in Skopje, Republic of Macedonia. The meeting provided an overview of the current and future use of next generation sequencing (NGS), proteomics and other high-throughput technologies in the diagnostic setup of malignant, inherited and communicable diseases. In addition, considerable emphasis was placed on the potential use of these techniques for disease prognostication, patient stratification and monitoring responses to therapy. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0053DOI Listing
December 2018

The Effect of Continuous Renal Replacement Therapy with the AN69ST Membrane on Inflammatory Markers and the Level of Consciousness of Hemodialysis Patients with Stroke: Comparison with Hemodialysis with Low Blood Flow Rate.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):29-35

Cardiovascular Center, Hanwa Memorial Hospital, 7-11-11 Karita, Sumiyoshi-ku,Osaka 558-0011, Japan.

Introduction: Hemodialysis (HD) with low blood flow rate, continuous renal replacement therapy (CRRT), and peritoneal dialysis are recommended for patients with stroke complications to prevent intracranial hypertension because of the low diffusion capacity of the brain barrier. However, detailed guidelines are not currently available; thus, there is an urgent need to establish such guidelines.

Material And Methods: We developed a novel protocol for performing CRRT with the AN69ST membrane, which has excellent adsorption capacity for various cytokines. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0039DOI Listing
December 2018

Community Acquired Legionnaire's Disease in a Kidney Transplant Patient.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):45-49

Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Zagreb, Croatia.

This case report details the clinical picture of a renal transplant recipient infected with community acquired Legionella pneumonia. While it is more commonly associated as a nosocomial infection due to pathogenic organisms in a hospital's water supply, this case serves as a reminder to consider the patient's impaired cellular immune function when trying to diagnose community acquired pneumonia. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0041DOI Listing
December 2018

Evaluation of Pain Following the Use of Scalpel Versus Electrosurgery for Skin Incisions in the Facial Regions.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):107-112

University Clinic for Plastic and Reconstructive Surgery, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.

Introduction: Postoperative pain presents a significant medical problem. It can create a considerable discomfort in the immediate postoperative period and thus increase patient's morbidity. Multiple mechanisms are involved in its' etiology, one of them being the method of tissue incision. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0048DOI Listing
December 2018
4 Reads

Opioid Free Anesthesia for Laparotomic Hemicolectomy: A Case Report.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):121-126

University Clinic for Thoracic and Vascular Surgery, Medical Faculty, University "Ss. Cyril and Methodius" Skopje, Republic of Macedonia.

Opioid free anesthesia (OFA) is deffined as anaesthesiological technique where opioids are not used in the intraoperative period (systemic, neuroaxial or intracavitary). Anaphylaxis caused by opioids (fentanyl) is very rare, and the reaction is presented with hypotension and urticaria. When we have proven allergy to fentanyl, patients' refusal of placing epidural catheter and refusal of receiving bilateral ultrasound guided transversus abdominis plane block (USG TAPB), we must think of using multimodal nonopioide analgesia. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0050DOI Listing
December 2018
1 Read

Myocardial Perfusion Abnormalities in Young and Premenopausal Women with Systemic Lupus Erythematosus, Detected with 99MTC MIBI Myocardial Perfusion Scintigraphy - Prevalence and Correlation with Proatherogenic Factors.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):79-92

University Clinic of Cardiology, Skopje, Republic of Macedonia.

Introduction: Atherosclerosis in young and premenopausal women with systemic lupus erythematosus (SLE) is frequent, premature and progressive. Although asymptomatic or with atypical clinical presentation, the patients are at high risk of cardiac events. Aim of this study is to estimate the risk profile for atherogenesis and the prevalence of myocardial perfusion abnormalities with 99mTc myocardial perfusion scintigraphy (MPS) in young and premenopausal women. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0045DOI Listing
December 2018
1 Read

Jakub Chlebowski, Rector Magnificus Exultus - A Distinguished Professor of Internal Medicine in Postwar North-East Poland.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):143-154

Department of Nephrology, Dialysis and Internal Medicine, Warsaw Medical University, Warsaw, Poland.

Jakub Chlebowski (Jakub Frydman) (1905-1969) was a distinguished professor of internal medicine and skillful organizer of health care system in Bialystok region in the North east Poland. He graduated medicine in 1929 and worked at local university in prewar Vilnius. During World War Two, arrested by the Soviets and exiled to Siberian work camps he managed to return to Poland with Kosciuszko Division of Polish Army. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0054DOI Listing
December 2018
1 Read

Assessment of Malnutrition Inflammation Score in Different Stages of Chronic Kidney Disease.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):51-61

Ex Resident,Department of Medicine Pt. B.D. Sharma University of Health Sciences, Rohtak(Haryana).

Background: Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD), and is associated with high morbidity and mortality. Malnutrition-Inflammation Score (MIS) has significant correlations with prospective hospitalization and mortality, as well as measures of anemia, inflammation, and nutrition in dialysis patients.

Material And Methods: The study was conducted on 100 adult patients of CKD selected from K&D clinic PGIMS, Rohtak. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0042DOI Listing
December 2018
5 Reads

Intrapartum Procedures for Prevention of Infections and Complications in Mothers During Childbirth.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):113-120

Institute of Social Medicine, Medical Faculty, "Ss. Cyril and Methodius" University of Skopje, Republic of Macedonia.

Introduction: Multiple factors can cause infection and other pathological conditions in mothers during childbirth. These risk factors and diseases/complications can be prevented or timely detected through the implementation of special protocols/procedures. The aim of this paper is to identify the implementation of procedures/measures for the prevention and detection of infections and risk factors for morbidity and mortality in four hospitals in the Republic of Macedonia, before and during childbirth. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0049DOI Listing
December 2018
4 Reads

Giant Fibroepithelial Polyp of Vulva: A Case Report and Review of Literature.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):127-130

Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia.

Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0051DOI Listing
December 2018
6 Reads

Inter- and Intra-Hemispheric EEG Coherence Study in Adults with Neuropsychiatric Disorders.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):5-19

Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.

Functional connectivity between different regions of the brain in the resting state has been a recent topic of interest in neurophysiological research. EEG coherence happened to be an useful tool for measuring changes in neuro-psycho-physiological functioning which are not detectable by simply measuring amplitude or power spectra. The aim of our study was to investigate the changes in the EEG coherence in groups of different mental disorders such as: depression, general anxiety disorder, ADHD, Asperger syndrome and headaches, compared to control group. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0037DOI Listing
December 2018
1 Read

Originally Adapted Mobile Application Used for Neuropsychiatric Patients.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):75-81

Ministry of Interior of the Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0026DOI Listing
July 2018
2 Reads

Analysis of Bone Metabolism in Children with Cystic Fibrosis.

Authors:
Tatjana Jakovska

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):151-155

University Children's Hospital, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0035DOI Listing
July 2018
3 Reads

Clinical Significance of Quantitative HBs Antigen in the Prediction of Liver Fibrosis in Patients with Chronic Hepatitis B.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):51-58

Institute of Epidemiology and Biostatistics, Faculty of Medicine, University "Ss. Cyril and Methodius", Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0023DOI Listing
July 2018
23 Reads

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):123-129

Faculty of Medical Sciences, University "Goce Delcev", Shtip, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0032DOI Listing
July 2018
4 Reads

Nt-ProBNP Discriminatory Role Between Symptomatic and Asymptomatic Patients with Severe Valvular Aortic Stenosis.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):15-28

Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, Skopje, Repubic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0020DOI Listing
July 2018
4 Reads

Homeostasis Model Assessment - Insulin Resistance and Sensitivity (HOMA-IR and IS) Index in Overweight Children Born Small for Gestational Age (SGA).

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):83-89

Macedonian Academy of Siences and Arts, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0027DOI Listing
July 2018
2 Reads

Lecturers from Macedonia Elected for the First Time to the Faculty of Medicine in Skopje in the Period 1961-63.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):157-179

Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0036DOI Listing
July 2018
2 Reads

Epidemiology of Community-Acquired Sepsis in Adult Patients: A Six Year Observational Study.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):59-66

University Clinic for Radiotherapy and Oncology, Medical Faculty, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0024DOI Listing
July 2018
5 Reads

Features of Parapneumonic Effusions.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):131-141

University Infectious Diseases Clinic, Medical Faculty, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0033DOI Listing
July 2018
2 Reads

Effects of Short Term Alendronate Administration on Bone Mineral Density in Patients with Chronic Kidney Disease.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):5-13

Assistant Professor,Department of Nephrology, AIIMS New Delhi.

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http://dx.doi.org/10.2478/prilozi-2018-0019DOI Listing
July 2018
2 Reads

Low Molecular Weight Proteinuria in Children with Distal Renal Tubular Acidosis.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):91-95

University Children's Hospital, Medical School Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0028DOI Listing
July 2018
3 Reads

Parameters of Metabolic Syndrome in Obese Children and Adolescents.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):105-114

Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0030DOI Listing
July 2018
2 Reads

Personality Typology in Patients with Traumatic Limb Fractures.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):67-74

Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0025DOI Listing
July 2018
1 Read

Growth Hormone Treatment in Children Born Small for Gestational Age (SGA).

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):143-149

University Children's Hospital, Medical Faculty Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0034DOI Listing
July 2018
2 Reads

The Impact of Glyco-Metabolic Status in Patients Treated for Acute Coronary Syndrome.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):37-50

University Clinic of Cardiology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0022DOI Listing
July 2018
12 Reads

Coping Styles Used for Mediation Dental Anxiety and Stress in School Children.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):97-102

DF Labs, Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0029DOI Listing
July 2018
2 Reads

Strategies to Enhance the Intravenous Treatment Satisfaction and Drug Safety Awareness Among Patients with Multiple Sclerosis in Macedonia.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Jul;39(1):115-121

Roche Macedonia DOOEL Skopje, Republic of Macedonia.

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http://dx.doi.org/10.2478/prilozi-2018-0031DOI Listing
July 2018
1 Read

The Use of Smartphone in Medical Practice.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):9-18

DFLab, Skopje, Republic of Macedonia.

In this review we present some data about the use of mobile phones in medical practice. The results of over hundred studies cited in PubMed during the last few years have been discussed. The article gives background connected with a project in the Macedonian Academy of Sciences and Arts referring to a personal mobile phone application named "Neurogame" which is currently constructed to evaluate motor skills related to attention and concentration in different samples of people. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0002DOI Listing
December 2017
1 Read

High Performance Liquid Chromatographic Method for Direct Determination of Diazepam in Whole Blood and Serum - Optimization of Solid-Phase Extraction Method.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):89-96

Institute of Preclinical and Clinical Pharmacology and Toxicology, Ss. Cyril and Methodius University, Medical Faculty, 50 Divizija bb,1000 Skopje, Republic of Macedonia.

Herein, we present a simple and rapid high performance liquid chromatographic (HPLC) method with UV-detection for the direct determination of diazepam in whole blood and serum that can be used for monitoring diazepam levels in clinical samples analysis. The isolation of diazepam and the internal standard bromazepam from serum and whole blood samples was performed using solid phase extraction method with RP select B cartridges. The analytes were separated employing a reversed phase C8 column with a mobile phase composed of 0. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0009DOI Listing
December 2017
5 Reads

Comparison of Two-Dimensional and Three-Dimensional Echocardiography in Determination of Left Ventricle Volumes and Ejection Fraction in Adult Population.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):105-112

University Clinic of Cardiology, Skopje, Republic of Macedonia.

Introduction: Left ventricle (LV) volumes and ejection fraction (EF) determined with two-dimensional echocardiography (2DE) and three-dimensional echocardiography (3DE) show significant differences.The aim of this study is to determine the agreement of the measurements of LV volumes and EF with 2DE and 3DE in the general adult population, with preserved LV systolic function.

Material And Methods: In 52 subjects, older than 65 years, LV end-diastolic volume index (EDVi), end-systolic volume index (ESVi) and EF were measured with 2DE and 3DE according to the official recommendations, and reproducibility of both methods and their agreement were determined. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0011DOI Listing
December 2017
2 Reads

The 6th Rare Disease South Eastern Europe (See) Meeting, Skopje, Macedonia (November 11th, 2017).

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):163-168

Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia.

The sixth SEE meeting on rare diseases (RDs) was held in MASA the November 10th, 2017. A block of lectures on rare renal diseases started the meeting: nephrotic syndrome, Alport syndrome, atypical HUS, hypophosphatemic rickets, CAKUT were presented in all complexities. Their molecular and genetic mechanisms were discussed. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0018DOI Listing
December 2017
5 Reads

Mobile Application "Neurogame" for Assessment the Attention, Focus and Concentration.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):55-62

Macedonian Academy of Sciences and Art, Skopje, Republic of Macedonia.

Smartphones are ubiquitous, but it is still unknown what physiological functions can be monitored at clinical quality. In medicine their use is cited in many fields (cardiology, pulmology, endocrinology, rheumatology, pediatrics as well as in the field of mental health). The aim of this paper is to explain how the use of mobile application can help clients to improve the index of their focus, concentration and motor skills. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0006DOI Listing
December 2017
2 Reads

Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):143-151

Department of Molecular Biology, Genetics and Microbiology, Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.

Telomerase Reverse Transcriptase (TERT) is the main catalytic sub-unit of telomerase, a reverse transcriptase enzyme. Telomerase expression is regulated at many levels, with numerous studies suggesting that up-regulation of human TERT gene (hTERT) at transcriptional level results in immortal cell phenotype associated with cancer. The aim of this study is to determine the correlation between hTERT expression and different cervical precursor lesions, as well as with cervical cancer in patients with confirmed Human papillomavirus (HPV) infection. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0015DOI Listing
December 2017
3 Reads

Clinical Significance of the Cerebral Perforating Arteries.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):19-29

Institute of Anatomy, Faculty of Medicine, University of Belgrade, Serbia.

There is scarce data in the contemporary literature regarding the correlation of the microanatomy of the perforating arteries, their atherosclerosis, and the ischemia in their territory. In order to examine, at least partially, those parameters, the perforating arteries of 12 brains were microdissected or their vascular casts were obtained. In addition, 30 specimens of the perforators were used for a histological and immunohistochemical study. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0003DOI Listing
December 2017
32 Reads

Factors That Influence Surgical Margin State in Patients Undergoing Cold Knife Conization - A Single Center Experience.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):113-120

Institute for Pathology, Medical Faculty Skopje, University "Ss. Cyril and Methodius", Skopje, Republic of Macedoniats.

Aim: To evaluate the factors that influence the surgical margin state in patients undergoing cold knife conization at the University Clinic of Gynecology and Obstetrics in Skopje, Republic of Macedonia Materials and methods: We have retrospectively analyzed the medical records of all patients that underwent a cold knife conization at our Clinic in 2015. We cross-referenced the surgical margin state with the histopathological diagnosis (LSIL, HSIL or micro-invasive/invasive cancer), menopausal status of the patients, number of pregnancies, surgeon experience, operating time and cone depth. The data was analyzed with the Chi square test, Fisher's exact test for categorical data and Student's T test for continuous data and univariate and multivariate logistical regressions were performed. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0012DOI Listing
December 2017
19 Reads

Rare Renal Disease in Macedonia - An Update.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):63-69

Macedonia Academy of Science and Arts, Skopje, Republic of Macedonia.

Rare renal diseases (RRD) are an important category of rare disease (RD) as they can do great damage to the patients, families and society. The patient may undergo years even decades of numerous investigations including invasive procedures and yet not have definitive and precise diagnose and therefore, no opportunity for appropriate treatment. The great progress in molecular genetic techniques characterized many Mendelian diseases on molecular level. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0007DOI Listing
December 2017
5 Reads

Craniosynostosis: Acrocephalosyndactyly (Apert Syndrome) Diagnosed in a Newborn.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):153-155

Medical Faculty Skopje, "Ss. Cyril and Methodius" University, Republic of Macedonia.

We report a 10 days old newborn with brachycephaly, midfacial hypoplasia, syndactyly and broad distal phalanx of thumb and big toe. At the 20th gestational weeks an enlargement of the left cerebral ventricle and malformation of the fingers of the hands and toes were noticed on a regular ultrasound examination. The aforementioned malformations were observed at birth and at the age of 11 months. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0016DOI Listing
December 2017
5 Reads

The History of Bone Tumour Treatment and the State of the Art in Vienna.

Authors:
Rainer Kotz

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):31-38

Wiener Privatklinik Betriebs-Ges.m.b.H. & Co.KG.

Purposes: Bone tumours have been a tragedy for the patient in any time period. In the majority of the cases it occurs in children or young adults. In the past the affected limbs could not be spared and the overall prognosis was poor. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0004DOI Listing
December 2017
6 Reads

Obesity in Childhood and Adolescence, Genetic Factors.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):121-133

Faculty of Medicine, University "Ss. Cyril and Methodius", 50 Divizija BB,1000 Skopje, Republic of Macedonia.

Obesity and excess weight are a pandemic phenomenon in the modern world. Childhood and adolescent obesity often ends up in obesity in adults. The costs of obesity and its consequences are staggering for any society, crippling for countries in development. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0013DOI Listing
December 2017
5 Reads

Evaluation of the Role of ABCB1gene Polymorphic Variants on Psychiatric Disorders Predisposition in Macedonian Population.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):71-88

The Macedonian Academy of Sciences and Arts", Skopje, Republic of Macedonia.

The psychiatric and other CNS disorders are characterized with unregulated neuro-inflammatory processes and chronic microglia cell activation resulting with detrimental effect. ABCB1gene polymorphismsC1236T, G2677T/Aand C3435T are associated with P-glycoprotein expression and function andare linked with predisposition to psychiatric disorders such as schizophrenia and bipolar disorders. The relationship between mood disorders and glucocorticoids has been confirmed and ABCB1 SNPs influence the glucocorticoids access to the brain. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0008DOI Listing
December 2017
8 Reads

Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2017 Dec;38(3):97-103

Institute of pathology, Faculty of Medicine, University "Ss. Cyril and Methodius" Skopje, Republic of Macedonia.

Herein synchronous occurrence of Hodgkin lymphoma and secondary myelodysplastic syndrome in a 60 year old male patient with small cell lung cancer treated with combined chemotherapy (carboplatin and paclitaxel) and radiotherapy is presented. The objective of this report is to stress the importance of documenting and monitoring adverse drug reactions that arise from chemotherapy. After four years of treatment with the combined chemotherapy, the patient presented inguinal lymphadenopathy and enlarged lymph nodes and histopathology rapport was suggestive for plasmacytoid variant of Castleman disease. Read More

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http://content.sciendo.com/view/journals/prilozi/38/3/articl
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http://dx.doi.org/10.2478/prilozi-2018-0010DOI Listing
December 2017
10 Reads