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Case Rep Psychiatry 2019 3;2019:4562065. Epub 2019 Jan 3.

Southern Illinois University Child Psychiatry, P.O. Box 19674, Springfield, IL 62794, USA.

With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on highly active antiretroviral therapy (HAART) who reported an incident of priapism potentially caused by an interaction between previously prescribed atypical antipsychotic, trazodone, norepinephrine dopamine reuptake inhibitor (NDRI), HAART, and newly added selective serotonin reuptake inhibitor (SSRI). This case emphasizes obtaining careful medication history, understanding cytochrome P450 (CYP450) enzyme and its subtypes, and discouraging polypharmacy. Read More

Int J Impot Res 2019 Feb 4. Epub 2019 Feb 4.

Boston University School of Medicine, Boston, MA, USA.

Penile shunting is the standard of care in management of ischemic priapism refractory (IPR) to non-surgical interventions. Due to high rates of impotence, corporal fibrosis, and loss of penile length, recent literature suggests these patients benefit from immediate penile prosthesis (PP) placement. An IRB-exempt anonymous electronic survey of the 2168 members of the International Society for Sexual Medicine (ISSM) was conducted. Read More

Eur Urol Focus 2019 Jan 25. Epub 2019 Jan 25.

Department of Andrology University College London Hospital, London, UK.

In refractory cases of priapism, prolonged ischaemia is associated with smooth muscle necrosis with the development of cavernosal fibrosis. Acute prosthesis placement allows maintenance of penile length and girth and treatment of the inevitable erectile dysfunction. Read More

Transfus Clin Biol 2019 Jan 10. Epub 2019 Jan 10.

Sickle Cell Institute Chhattisgarh, Forest Block-2, Jail Road, Raipur 492001, Chhattisgarh India. Electronic address:

Sickle cell disease (SCD) is considered as a vascular disease due to its chronic vascular manifestations such as leg ulcers, priapism, acute chest syndrome (ACS), stroke, retinopathy, renal insufficiency, pulmonary hypertension, avascular necrosis of the femoral head (AVNF) and splenic infarction. Emerging evidence has shown that the MTHFR 677C>T variant allele is associated with vascular complications (VC) in patients with SCD; however, results from individual studies are inconclusive. The aim of this meta-analysis is to evaluate the association between the MTHFR 677C>T polymorphism and the susceptibility for VC in SCD patients. Read More

J Pain Symptom Manage 2019 Feb 26;57(2):e4-e5. Epub 2018 Oct 26.

Clínica de Dolor, Instituto Nacional de Cancerología, México.

Adv Ther 2019 Jan 25. Epub 2019 Jan 25.

Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Introduction: To present 12 cases of arterial priapism treated by superselective embolization and propose our management algorithm for this condition.

Methods: Between February 2013 and May 2018, 12 cases of arterial priapism caused by blunt trauma were treated by superselective embolization. The mean age of patients was 36 years (25-47 years). Read More

J Urol 2019 Jan 16. Epub 2019 Jan 16.

Am J Emerg Med 2019 Jan 11. Epub 2019 Jan 11.

Emergency Department, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.

Erector spinae plane block (ESPB) is a novel block where local anesthetic is deposited between the erector spinae muscle and the underlying transverse process. Safety of this technique is emphasized in the majority of reports, but with a continued increase of its use, the number of related complications and side effects is likely to expand. We report the case of a patient treated with ESPB for a complex regional pain syndrome, complicated by the development of a priapism. Read More

Med J Malaysia 2018 Dec;73(6):420-422

Hospital Sultanah Aminah, Department of Urology, Johor Bahru, Malaysia.

Priapism is a rare clinical presentation of a patient with chronic myeloid leukaemia (CML). Herein, we present a young Nepalese man that presented to the emergency department with an acute and painful penile erection for two days. Clinically, he was pale and abdominal examination revealed hepatomegaly. Read More

Eur Urol Focus 2019 Jan 10. Epub 2019 Jan 10.

Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA. Electronic address:

In patients presenting with early ischemic priapism, proceeding with the conventional paradigm is recommended. In those presenting late (>48 h), penile prosthesis placement can easily be performed 2-6 wk later, with no increase in surgical difficulty or morbidity. Immediate penile prosthesis implantation should be reserved for motivated patients who understand the increased associated risks, have evidence of corporal fibrosis on imaging, and are being treated in a center of excellence. Read More

Br Dent J 2019 Jan;226(1):27-31

Henri Mondor Hospital, Dental Department, Paris-Descartes University, Ile-de France, France.

Sickle cell disease is one of the most common autosomal recessive genetic diseases. It gives rise to abnormally shaped red blood cells with altered function, the primary clinical features being haemolytic anaemia and vascular occlusion. Acute complications are frequent and variable and include chest syndrome, stroke, infection mainly due to asplenia, bone pain and priapism. Read More

J Coll Physicians Surg Pak 2019 Jan;29(1):78-80

Department of Medicine, Lok Nayak Hospital, New Delhi, India.

Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly. Priapism is a rare manifestation of CML and is mostly due to hyperleukocytosis. Its debut appearance as a sign of hematological dyscrasia is a rare event. Read More

Health Sci Rep 2018 Nov 5;1(11):e88. Epub 2018 Sep 5.

Graduate School of Nursing, Midwifery and Health Victoria University of Wellington Wellington New Zealand.

Objective: To describe self-management recommendations for sickle cell disease (SCD) care among health professionals who manage SCD in Ghana.

Method: Nine health care professionals (nurses, doctors, and physician assistants) who work in SCD were interviewed. The semistructured interviews were recorded, transcribed, and analysed using the qualitative content analysis method. Read More

Front Med (Lausanne) 2018 20;5:323. Epub 2018 Nov 20.

Cardiology Department, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris and UMR_S970, Université Paris Descartes, Inserm, Paris, France.

Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years. Read More

Sex Med 2019 Mar 3;7(1):111-113. Epub 2018 Dec 3.

Department of Urology, CES University, Medellin, Colombia.

Introduction: Priapism is defined as a persistent penile erection lasting longer than 4 hours and unrelated to sexual activity. It is one of the most common emergencies treated by urologists. Advances in understanding the pathophysiology of various types of priapism have led to targeted management strategies according to type of priapism. Read More

Pediatr Rev 2018 Dec;39(12):617-619

Division of Pediatric Hematology and Oncology, Department of Pediatrics.

Sex Med Rev 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, Tulane University, New Orleans, LA, USA. Electronic address:

Background: Priapism has been linked to many commonly prescribed medications, as well as recreational drugs and toxins. Although the incidence of priapism as a result of medication is small, the increasing use of antidepressants, antipsychotics, and recreational drugs may lead to more cases of pharmacologically-induced priapism in the future.

Aim: To provide a comprehensive, up-to-date review of the most common causes of pharmacologically induced priapism and discuss incidence, pathophysiology, and basic management strategies. Read More

Rev Int Androl 2018 Nov 27. Epub 2018 Nov 27.

Radiology Department, Hospital Clínico Universitario de Santiago de Compostela, Spain.

Partial thrombosis of corpus cavernosum is an uncommon condition that needs a high level of suspicious to be diagnosed. Imaging techniques may be very useful, and MR is the state-of-the-art technique. We present a case of a young male who presented to the emergency department with perineal and painful mass. Read More

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Purpose: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.

Methods: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1442-1443

Department of Hematology, SGPGI, Lucknow, Uttar Pradesh, India.

Urology 2018 Nov 22. Epub 2018 Nov 22.

Cleveland Clinic Foundation, Glickman Urological & Kidney Institute, Cleveland, OH.

J Urol 2018 Sep 1;200(3):490-492. Epub 2018 Jun 1.

Cir Pediatr 2018 Oct 17;31(4):200-203. Epub 2018 Oct 17.

Servicio de Cirugía Pediátrica. Hospital Universitario Central de Asturias. Oviedo.

Introduction: High-flow priapism is infrequent in pediatric patients. It is mostly secondary to perineal trauma resulting in laceration of a penile artery and the formation of an arterio-cavernous fistula. It does not constitute a medical emergency in itself, and allows conservative management awaiting spontaneous resolution. Read More

Arch Ital Urol Androl 2018 Sep 30;90(3):218-219. Epub 2018 Sep 30.

Department of Urology, University of Trieste, Cattinara Hospital, Trieste.

Introduction: High-flow priapism is a rare condition in children, usually due to a perineal trauma.

Materials And Methods: We present a case of traumatic highflow priapism investigated by Doppler ultrasound and managed by angiography and selective embolization of a branch of the internal pudendal artery.

Results: A 13-year-old gymnast underwent perineal trauma during training and developed a high-flow priapism. Read More

Curr Drug Saf 2019 ;14(1):21-26

Department of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bengaluru, India.

Background: The signal is defined as "reported information on a possible causal relationship between an adverse event and a drug, of which the relationship is unknown or incompletely documented previously".

Objective: To detect novel adverse events of iloperidone by disproportionality analysis in FDA database of Adverse Event Reporting System (FAERS) using Data Mining Algorithms (DMAs).

Methodology: The US FAERS database consists of 1028 iloperidone associated Drug Event Combinations (DECs) which were reported from 2010 Q1 to 2016 Q3. Read More

Indian J Urol 2018 Oct-Dec;34(4):283-286

Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Introduction: We aim to present a modified technique and outcomes of a novel method allowing for direct visualization of the reservoir placement during a penoscrotal inflatable penile prosthesis (IPP).

Methods: Out of165 patients who underwent IPP placement from August 2012 to March 2015, 157 underwent a modified technique and comprised the cohort of this study. A Deaver's retractor was placed lateral to the penis and over the pubic bone to allow for direct visualization of the tissues overlying the lower abdomen. Read More

Eur Urol Focus 2018 04 14;4(3):338-347. Epub 2018 Oct 14.

Division of Male Reproductive Surgery and Men's Health, Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Imaging can benefit clinicians in evaluating men with infertility or sexual dysfunction by giving an overview of a patient's overall clinical condition before undertaking an invasive procedure. An understanding of the limitations and advantages of image modalities used in clinical practice will ensure that clinicians can optimize patient care with imaging when necessary. PATIENT SUMMARY: The objective of this article was to review the current literature on imaging modalities used for the diagnosis and management of male infertility and sexual dysfunction. Read More

J Pak Med Assoc 2018 Jun;68(6):942-944

Rehman Medical Institute.

Priapism is known as a very rare complication of leukaemia. We report a 16-years boy who presented with the persistent painful erection of the penis for eleven days. He had aspiration without achieving sustained detumescence. Read More

Rev Bras Enferm 2018 Sep-Oct;71(5):2418-2424

Universidade Federal da Bahia, School of Nursing. Salvador, Bahia, Brazil.

Objective: To identify self-care demands of men with sickle cell disease and priapism and describe self-care measures in light of Orem's Self-Care Theory.

Method: This is a descriptive exploratory study with qualitative approach conducted with nine men with a history of sickle cell disease and priapism. Data were analyzed using Orem's Self-Care Theory. Read More

Drug Des Devel Ther 2018 12;12:2923-2931. Epub 2018 Sep 12.

Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary,

Purpose: Papaverine hydrochloride (PaHCl) is an old, well-known drug with spasmolytic activity but it has therapeutic effect in erectile dysfunction, too. As an intracavernous injection, it is not used in urologic clinics today because the side effects of the injection are pain, scarring or priapism. Our aim was to develop and test a topical semi-solid preparation containing PaHCl that would provide an alternative administration option by eliminating the undesirable side effects of the injection. Read More

Vasc Health Risk Manag 2018 6;14:199-204. Epub 2018 Sep 6.

Comprehensive Sickle Cell Program Children's National Medical Center, Division of Hematology, School of Medicine and Health Sciences George Washington University, Washington, DC, USA.

Background: Nitric oxide (NO) plays a fundamental role in maintaining normal vasomotor tone. Recent clinical and experimental data suggest that NO may play a role in the pathogenesis and therapy of sickle cell disease (SCD). The aim of this study was to determine NO metabolites (NOx) in SCD patients at steady state and in vaso-occlusive crisis (VOC), as well as those with hemolytic clinical sub-phenotype that includes leg ulcers and priapism. Read More

World J Biol Psychiatry 2018 Sep 13:1-17. Epub 2018 Sep 13.

a University Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School , Immanuel Klinik Rüdersdorf , 15662 Rüdersdorf , Germany.

Priapism is a rare adverse effect of several psychotropics. Both, typical and atypical antipsychotics, as well as trazodone are known to cause priapism. The mechanism is still not fully understood, however, the most common assumption is that priapism occurs due to the α-adrenergic blocking effects of the drugs. Read More

Radiol Bras 2018 Jul-Aug;51(4):257-261

MD, Urologist, Member of the Clinical Staff of the Urology Department of the Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

Ultrasound is an excellent method for the study of penis. In this article, using a critical review of the literature and teaching files, we present examples of the major findings in the ultrasound routine, focusing on trauma, priapism, Peyronie's disease, and erectile dysfunction. Read More

Prog Urol 2018 Nov 7;28(14):772-776. Epub 2018 Sep 7.

Department of Urology, Pitié Salpétrière Hospital, Sorbonne Université, 47-83 boulevard de l'Hôpital, 75013 Paris, France. Electronic address:

Objective: Our aim was to present a synthesis on the diagnosis and treatment of priapism.

Methods: For this purpose, a literature search was performed through PubMed to analyze literature reviews and guidelines regarding priapism.

Results: Priapism is an erection that persists more than 4hours. Read More

Zhonghua Nan Ke Xue 2018 Aug;24(8):675-680

Department of Urology, Donghua Hospital Affiliated to Sun Yat-sen University, Dongguan, Guangdong 523120, China.

Priapism is a rare pathological penile erection, and there are some inadequacies in its definition, classification, diagnosis, and therapeutic strategies. In this article, we sum up our years of experience with priapism and put forward some new views and ideas about its definition, classification, pathophysiologic process, pathological change, diagnostic essentials, therapeutic measures, indications of successful treatment, and post-therapeutic rehabilitation of erectile function. We also describe the clinical features, diagnosis and treatment of some special types of priapism, such as intermittent seizure, sleep-related painful erection, and tumor-related priapism, hoping to help urologists and andrologists in the further understanding and management of priapism. Read More

Zhonghua Nan Ke Xue 2018 Janurary;24(1):59-61

Department of Urology, The 9th People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Objective: To introduce our experience in the treatment of arterial priapism by superselective embolization.

Methods: This study included 5 cases of perineal trauma-induced arterial erectile dysfunction treated in our departmentbetween February 2011 and May 2015, all failingpreviously to respond to 3 weeks of conservative treatment. The patients were aged 25－47 (mean 35) years, with the onset of arterial priapism at 2－5 days after trauma, and all subjected to physical examination, blood gas analysis, color Doppler ultrasonography of the corpora cavernosum, and IIEF-5 scoring. Read More

Zhonghua Nan Ke Xue 2018 Feb;24(2):163-167

Department of Ultrasonic Medicine, The 10th People's Hospital of Tongji University, Shanghai 200072, China.

Penile disease is one of the male urological diseases. Although the penis is a small organ, once the problem occurs, it often brings great trouble to the patient. Therefore, the accurate diagnosis of penile disease is particularly important. Read More

Int Braz J Urol 2018 Sep-Oct;44(5):1023-1031

Department of Urology, Harran University Medical School, Sanliurfa, Turkey.

Objective: To protect the urethra from instrumentation related urethra injures and stricture, we developed a new surgical technique which can be defined as transvesical resection of prostate without using urethra.

Materials And Methods: Our study included 12 consecutive bladder outlet obstruction patients treated with transvesical prostate resection in our clinic between March 2016 and May 2016. Detailed anamnesis, results of physical examination, digital rectal examination, routine lab tests, international prostate symptoms score, transrectal ultrasound, measurement of prostate-specific antigen levels and uroflowmetry was performed in all patients prior to surgery. Read More

BMJ Case Rep 2018 Aug 14;2018. Epub 2018 Aug 14.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Cureus 2018 Jun 7;10(6):e2758. Epub 2018 Jun 7.

Graduate Medical Education, Florida Hospital-Orlando, Orlando, USA.

Priapism, a persistent erection of the penis which has no association with sexual activity and lasts longer than four hours, is a urologic emergency. It can be classified into ischemic, nonischemic, and stuttering categories. The pathophysiology of stuttering priapism is not well understood; however, the dysregulation of nitric oxide and phosophodiesterase-5 (PDE5) has been put forward as a possible mechanism. Read More

Curr Med Sci 2018 Feb 15;38(1):101-106. Epub 2018 Mar 15.

Department of Infertility and Sexual Medicine, Guangzhou, 510630, China.

This study is aimed to evaluate the effectiveness and safety of the treatment of highflow priapism with superselective transcatheter embolization. From Sep. 1999 to Jan. Read More

Urology 2018 Dec 29;122:116-120. Epub 2018 Jul 29.

Department of Radiology, Division of Vascular and Interventional Radiology, University of Michigan Health Systems, Ann Arbor, MI; Department of Interventional Radiology, University of California, 757 Westwood Plaza, Los Angeles, CA 90095.

Objective: To report long term outcomes of selective arterial embolization for nonischemic priapism on erectile function utilizing validated outcome questionnaires after selective arterial embolization.

Materials And Methods: Twenty men, mean age of 36 years (range: 8-58 years), underwent selective penile embolization for nonischemic priapism between December 1997 and February 2016 (218 months). Each identified case of nonischemic priapism was embolized using gelatin sponge, autologous blood clot, platinum microcoils, polyvinyl alcohol particles, or a combination of these. Read More

Ital J Pediatr 2018 Jul 27;44(1):85. Epub 2018 Jul 27.

Department of Surgical Science, University of Cagliari and Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, Cagliari, I-09042, Italy.

Neonatal priapism is a rare condition with only 26 described cases in literature since 1879. It is defined as a persistent penile erection occurring in the first 28 days of life, lasting at least 4 h that usually happens in the first days (from 2 to 12 days). It is a very different condition compared to the adult one because in newborns it is a relatively benign phenomenon. Read More

Ned Tijdschr Geneeskd 2018 Jun 15;162. Epub 2018 Jun 15.

UMCG-Rijksuniversiteit Groningen, afd. Urologie, Groningen.

The term priapism describes erections of >4 hours that arise in the absence of or last well beyond sexual stimulation. Ischaemic priapism is the most common form and treatment success is strongly dependent on the duration of priapism. The aetiology is widely variable as a result of which several specialisms can be confronted with this condition. Read More

Niger J Clin Pract 2018 Jul;21(7):882-887

Hematology and Hemotherapy Center, University of Campinas, São Paulo, Brazil.

Background: Sickle leg ulcer (SLU) is a chronic and debilitating complication of sickle cell disease (SCD) associated with huge physical and psychosocial discomfort. The occurrence of SLU has remained steady despite successful preventive strategies and advances in SCD care. Although multifactorial factors have been implicated in SLU, these are not fully understood, and data on how these relate to young Nigerian SCD patients are scanty. Read More

J Sex Med 2018 Jul;15(7):990-996

Columbia Urology Division of Urology at Mount Sinai Medical Center, Miami Beach, FL, USA.

Aim: We sought to evaluate whether the administration of phenylephrine (PE) at concentrations higher than those described in guidelines resulted in any significant changes in vital signs or impacted outcomes.

Methods: After receiving institutional review board approval, we retrospectively reviewed the charts of patients presenting to our emergency department between May 1, 2014, and August 15, 2016, using International Classification of Diseases, Ninth Edition and Internation Classification of Disease, Tenth Edition diagnosis codes for priapism. Treatment was reviewed, including corporal aspiration/irrigation, injection of PE, and shunt procedures. Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 28;119(6):493-497. Epub 2018 Jun 28.

Department of maxillofacial and plastic surgery, Caen university hospital, 14000 Caen, France; Medicine faculty of Caen, university of Caen Basse Normandie, 14032 Caen cedex 5, France; UNICAEN, EA7451 Équipe BioConnecT, avenue de la Côte-de-Nacre, 14000 Caen, France.

Sickle cell disease, the most common genetic disease in the world, is a chronic hemolytic disease that can be complicated by severe vaso-occlusive pain crises resulting in tissue necrosis and even death. Due to its increasing incidence, oral surgeons will inevitably be faced with the management of these patients. To limit the risk of crises, our goal is to share recommendations for the management of sickle cell patients in oral surgery. Read More