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Andrologia 2022 Jun 23:e14505. Epub 2022 Jun 23.

Department of Urology, Tallaght University Hospital, Dublin 24, Ireland.

Priapism is defined as a full or partial erection lasting greater than 4 h due to a fault in the normal detumescence mechanism of the penis. We describe the case of a confused 73-year-old gentleman presenting with painless priapism, a 2 cm non-tethered lesion in the scrotum and a vague palpable pelvic mass. On the presumption that this was a case of high-flow non-ischaemic priapism secondary to pelvic malignancy, the urology registrar attempted corporal body aspiration. Read More

Nat Rev Urol 2022 Jun 16. Epub 2022 Jun 16.

University of Western Ontario, London, Ontario, Canada.

Despite significant scientific advances in the modern three-piece inflatable penile prosthesis implant surgery, it is not without surgical risks and can carry additional cosmetic and psychosocial consequences in poorly selected and consented individuals. To address this problem, an international group of key opinion leaders and high-volume prosthetic surgeons reviewed the current guidelines and clinical evidence, discussed their experiences, and formed a consensus regarding inflatable penile prosthesis surgery. The findings of this consensus panel were presented at the 17th biennial Asia Pacific Society of Sexual Medicine scientific meeting. Read More

Toxicon 2022 Jun 9;215:11-16. Epub 2022 Jun 9.

School of Pharmacy, University of Reading, UK. Electronic address:

Snakebite envenomation is a high priority neglected tropical disease that predominantly affects rural communities living in developing countries. Due to myriad of complications including coagulopathies, neurotoxicity, nephrotoxicity and local tissue destruction, treating snakebite victims is a major challenge for clinicians. Russell's viper (Daboia russelii) is one of the 'Big Four' venomous snakes in India, and it is responsible for the most snakebite-induced deaths and disabilities. Read More

PLoS One 2022 2;17(6):e0269310. Epub 2022 Jun 2.

Laboratory of Multidisciplinary Research, São Francisco University Medical School, Bragança Paulista, SP, Brazil.

Background: Children and adult with sickle cell disease (SCD) display priapism associated with low nitric oxide (NO) bioavailability and oxidative stress in penis.

Aim: This study aimed to evaluate the effects of hybrid compound RVT-FxMe, derived from resveratrol bearing a NO-donor subunit, on two murine model that display priapism phenotype, SCD transgenic mice and endothelial NO synthase gene-deficient (eNOS-/-) mice.

Methods: Wild-type, SCD, and eNOS-/- mice were treated with RVT-FxMe (25 mg/kg/d, 2 weeks). Read More

Urol Case Rep 2022 Jul 20;43:102118. Epub 2022 May 20.

Urology Department, Centro Universitário FMABC, Santo André, São Paulo, Brazil.

Corpus cavernosum abscess is a rare infection of the genitourinary tract. In this case report, we present a 42-year-old patient admitted with pain and edema in the penile shaft twenty-four days after drainage by puncture of the cavernous body due to ischemic priapism. Al-Ghorab procedure together snake-maneuver and broad-spectrum antibiotic therapy were performed. Read More

Ann Med Surg (Lond) 2022 May 29;77:103696. Epub 2022 Apr 29.

Urology Department La Rabta Hospital, Tunis, Tunisia.

Introduction: Ischemic Priapism is defined as an abnormally prolonged state of erection, exceeding 6 h, often and irreducible, occurring without any sexual stimulation. Ischemic priapism has a fatal consequence on the sexual function of men if it's not promptly managed. This pathology can cause erectile dysfunction and this can alter the quality of life of patients. Read More

Prog Urol 2022 May 24. Epub 2022 May 24.

Service d'urologie de l'Hôpital Général Idrissa Pouye, Dakar, Sénégal. Electronic address:

Objectives: The objective of this study was to evaluate the sexuality of SS sickle cell patients with a history of priapism.

Methods: This was a case-control study of adult SS sickle cell patients. The occurrence of priapism as well as the nature of the priapism had been investigated. Read More

Int J Impot Res 2022 May 21. Epub 2022 May 21.

Università Vita-Salute San Raffaele, Milan, Italy.

A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most priapism-reports; and, b) within these medications, comparing their potential to elicit priapism through a disproportionality analysis. The FDA Adverse Event Reporting System (FAERS) database was queried to identify those drugs associated the most with priapism reports over the last 5 years. Read More

Front Endocrinol (Lausanne) 2022 3;13:892184. Epub 2022 May 3.

Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, United States.

Hypogonadism is common in men with sickle cell disease (SCD) with prevalence rates as high as 25%. Testicular failure (primary hypogonadism) is established as the principal cause for this hormonal abnormality, although secondary hypogonadism and compensated hypogonadism have also been observed. The underlying mechanism for primary hypogonadism was elucidated in a mouse model of SCD, and involves increased NADPH oxidase-derived oxidative stress in the testis, which reduces protein expression of a steroidogenic acute regulatory protein and cholesterol transport to the mitochondria in Leydig cells. Read More

Pediatrics 2022 06;149(6)

Departments of Urology.

Although rare in pediatrics, ischemic priapism carries significant risk of erectile dysfunction if not treated promptly. We report a case of idiopathic ischemic priapism in a male aged 14 years, refractory to traditional therapies, including aspiration/irrigation, phenylephrine injection, and distal shunt. However, the priapism resolved after intracavernosal injections of tissue plasminogen activator (tPA) with preservation of normal erectile function. Read More

Curr Urol Rep 2022 Jul 10;23(7):143-153. Epub 2022 May 10.

Boston Medical Center, Boston University School of Medicine, 725 Albany street, suite 3B, Boston, MA, 02118, USA.

Purpose Of Review: Priapism is a rare condition that has different presentations, etiologies, pathophysiology, and treatment algorithms. It can be associated with significant patient distress and sexual dysfunction. We aim to examine the most up-to-date literature and guidelines in the management of this condition. Read More

J Urol 2022 07 10;208(1):43-52. Epub 2022 May 10.

Northwestern University, NMH/Arkes Family Pavilion; Chicago, Illinois.

Purpose: Priapism is a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation and results in a prolonged and uncontrolled erection. Given its time-dependent and progressive nature, priapism is a situation that both urologists and emergency medicine practitioners must be familiar with and comfortable managing.

Methodology: A comprehensive search of the literature on acute ischemic priapism and non-ischemic priapism (NIP) was performed by Emergency Care Research Institute for articles published between January 1, 1960 and May 1, 2020. Read More

Eur J Ophthalmol 2022 May 3:11206721221098880. Epub 2022 May 3.

Ophthalmology Unit, 9370University Hospital of Parma, Parma, Italy.

Purpose: To report a case of possible multi-district thromboembolic event involving the eye of a patient with several cardiovascular risk factors, following a second inoculation of SARS-CoV-2 m-RNA based vaccine.

Case-report: A 60-year-old man presented with blurred vision in the left eye lasting 1 month but started within 24 hours from the 2 dose of BNT162b2 vaccine inoculation. He also reported a long-lasting but self-limiting priapism which started about 4 h after the vaccination. Read More

Ulus Travma Acil Cerrahi Derg 2022 Apr;28(4):464-470

Department of Pediatric Surgery, Division of Pediatric Urology, Uludağ University Faculty of Medicine, Bursa-Turkey.

Background: Priapism is a rare condition in children and the treatment algorithm is controversial in this age group. Herein, we report eight cases with low-flow priapism and our stepwise treatment approach in light of literature.

Methods: We present a simple stepwise treatment for low-flow priapism including five steps. Read More

Front Mol Biosci 2022 11;9:831823. Epub 2022 Apr 11.

Departmentamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

The venom of the "armed" spider comprises several potent toxins. One of the most toxic components from this venom is the neurotoxin PnTx2-6 (LD = ∼ 0.7 μg/mouse, 48 residues, five disulfide bridges, MW = 5,289. Read More

Adv Emerg Nurs J 2022 Apr-Jun 01;44(2):121-126

Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.

Patients presenting to the emergency department with priapism require immediate evaluation and treatment. Priapism is a urological emergency that carries the risk of erectile dysfunction if not managed in a timely manner. Therefore, it is important for providers to be able to identify and manage these patients emergently. Read More

Hinyokika Kiyo 2022 Mar;68(3):91-94

The Department of Urology, Osaka University Graduate School of Medicine.

The first-line treatment for arterial (traumatic) priapism is follow-up, but no recommended duration has been established. We report a case of traumatic priapism that did not improve after one year of follow-up and was cured by arterial embolization. The patient was a 21-year-old male with a urethral injury caused by traffic trauma, and a urethral catheter was placed under fluoroscopic guidance. Read More

Andrology 2022 Apr 23. Epub 2022 Apr 23.

UROGIV Research Group, School of Medicine, Universidad del Valle, Cali, Colombia.

Aim: To describe the association between partial thrombosis of the corpus cavernosum, partial priapism, and hard flaccid syndrome.

Methods: A scoping review was performed according to the recommendations of the Joanna Briggs Institute. Moreover, we performed a search strategy using the MEDLINE, EMBASE, and CENTRAL databases. Read More

Toxins (Basel) 2022 04 6;14(4). Epub 2022 Apr 6.

School of Pharmacy, University of Reading, Reading RG6 6UB, UK.

Russell's viper (), one of the 'Big Four' venomous snakes in India, is responsible for the majority of snakebite-induced deaths and permanent disabilities. Russell's viper bites are known to induce bleeding/clotting abnormalities, as well as myotoxic, nephrotoxic, cytotoxic and neurotoxic envenomation effects. In addition, they have been reported to induce rare envenomation effects such as priapism, sialolithiasis and splenic rupture. Read More

BMJ Case Rep 2022 Apr 19;15(4). Epub 2022 Apr 19.

Department of Urology, Austin Health, Heidelberg, Victoria, Australia.

Priapism is an urgent urological condition with varied aetiology that may be classified as low flow (ischaemic) or high flow (non-ischaemic). Diagnosis requires detailed clinical history and examination combined with appropriate investigations such as cavernosal blood gas sampling and penile Doppler ultrasound. In the case of high-flow priapism CT angiography can identify sources of abnormal arterial blood flow and cases may be managed conservatively, with surgery or through arterial embolisation. Read More

J Med Vasc 2022 Feb 1;47(1):27-32. Epub 2021 Dec 1.

Radiology Department, University Hospital Gabriel-Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand, France.

We report the case of a 14-year-old man who arrived at the emergency department affected by a high-flow priapism due to a traumatic left arterial-sinusoidal fistula. After clinical examination, a colour Doppler ultrasound of the penis was performed which showed a left arterial-sinusoidal fistula measuring 7×16×30mm, with high-speed and turbulent flow. The fistula was successfully treated by three highly selective endovascular embolizations and at the 20days follow-up, clinical examination resulted normal. Read More

Blood 2022 04;139(14):2258

The University of Texas, MD Anderson Cancer Center.

Cureus 2022 Feb 25;14(2):e22613. Epub 2022 Feb 25.

Urology, Colchester Hospital, East Suffolk and North Essex National Health Service (NHS) Foundation Trust, Colchester, GBR.

On 11 March 2020, the World Health Organisation (WHO) declared the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) (COVID-19) a pandemic. With a global incidence of over 414 million cases, as of 16 February 2022, it presents a significant burden on healthcare. COVID-19 is primarily considered a respiratory illness; however, a wide range of presentations have been reported including a tendency for thrombotic complications. Read More

Int J Impot Res 2022 Mar 28. Epub 2022 Mar 28.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

BMJ Case Rep 2022 Mar 21;15(3). Epub 2022 Mar 21.

Department of Urology, Singapore General Hospital, Singapore.

We describe the case of a metastatic penile tumour of hepatocellular origin treated with surgical resection. Read More

BMC Urol 2022 Mar 11;22(1):35. Epub 2022 Mar 11.

Division of General Internal Medicine, University of British Columbia, Vancouver, BC, Canada.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a systemic lymphoproliferative disorder characterized by elevated serum IgG4 levels and tumefactive lesions that can involve nearly every organ system. Involvement of the prostate is rare but has been reported in limited cases.

Case Presentation: A 28-year-old man of Asian descent with a history of sinusitis and priapism presented to hospital with rigors and voiding symptoms. Read More

Int J Impot Res 2022 Mar 8. Epub 2022 Mar 8.

Department of Urology, Columbia University Irving Medical Center,, New York, NY, USA.

While consensus exists regarding risk factors for priapism, predictors of operative intervention are less well established. We assessed patient and hospital-level predictors associated with penile surgical intervention (PSI) for patients admitted with acute priapism, as well as length of stay (LOS) and total hospital charges using the National Inpatient Sample (2010-2015). Inpatients with acute priapism were stratified by PSI, defined as penile shunts, incisions, and placement of penile prostheses, exclusive of irrigation procedures. Read More

Curr Pharm Biotechnol 2022 Mar 7. Epub 2022 Mar 7.

Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Kraków, Poland | Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, Zabrze, Poland.

Background: Widely known fact about Sars-Cov-2 infection's impact on urogenital system may play relevant role in under-standing, diagnose and future prevention of male urological disorders. Sars-CoV-2 attacks vascular endothelium of the entire organism therefore infection complications are visible in various organs. Relatively small number of original studies on Sars-cov-2 infection and the effect on the reproductive system and fertility in men. Read More

J Inherit Metab Dis 2022 05 28;45(3):621-634. Epub 2022 Feb 28.

Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Japan.

6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for aromatic L-amino acid hydroxylases, including tyrosine hydroxylase (TH), alkylglycerol monooxygenase, and three types of nitric oxide (NO) synthases (NOS). Sepiapterin reductase (SPR) catalyzes the third step of BH4 biosynthesis. SPR gene-disrupted (Spr ) mice exhibit a dystonic posture, low body weight, hyperphenylalaninemia, and unstable hypertension with endothelial dysfunction. Read More

J Sex Med 2022 05 17;19(5):879-886. Epub 2022 Feb 17.

Department of Urology, University College London Hospital, London W1G 8PH, UK.

Background: In 2016, we reported the first case of high flow priapism and arteriocavernosal fistula caused by penile prosthesis insertion that mimicked device autoinflation.

Aim: To raise awareness amongst implanters, we describe further cases from our institution and perform a systematic review of the literature to understand the rarity of this phenomenon.

Methods: Patient demographics, management and outcomes were extracted retrospectively. Read More