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BMC Urol 2020 Jun 30;20(1):79. Epub 2020 Jun 30.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No.1, East Jian She Road, Zhengzhou, 450052, China.

Background: This study aimed to report long-term outcome of superselective embolization in patients with high-flow priapism refractory to medical and surgical treatments.

Methods: From August 2011 until July 2016, 14 patients with high-flow priapism refractory to local treatments were treated and their charts were retrospective reviewed. Clinical evaluation, color Doppler ultrasonography, arteriography and selective embolization were performed. Read More

Curr Probl Diagn Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiology and Imaging, Medical College of Georgia, Augusta, GA.

Sickle cell disease is a debilitating hematologic process that affects the entire body. Disease manifestations in the abdomen most commonly result from vaso-occlusion, hemolysis, or infection due to functional asplenia. Organ specific manifestations include those involving the liver (eg, hepatopathy, iron deposition), gallbladder (eg, stone formation), spleen (eg, infarction, abscess formation, sequestration), kidneys (eg, papillary necrosis, infarction), pancreas (eg, pancreatitis), gastrointestinal tract (eg, infarction), reproductive organs (eg, priapism, testicular atrophy), bone (eg, marrow changes, avascular necrosis), vasculature (eg, vasculopathy), and lung bases (eg, acute chest syndrome, infarction). Read More

Basic Clin Androl 2020 4;30. Epub 2020 Jun 4.

Department of urology, Clinique Turin, Paris, France.

Introduction: Hard-flaccid syndrome is gaining increased interest among male sexual dysfunctions in the last years. It is poorly understood and defined. Most of the information comes from online forums. Read More

J Urol 2020 Jun 9:101097JU0000000000001183. Epub 2020 Jun 9.

Department of Urology, Jackson Memorial Hospital and University of Miami Miller School of Medicine, Miami, Florida.

Purpose: Ischemic priapism is a urological emergency that requires prompt intervention to preserve erectile function. Characteristics that influence escalation to surgical intervention remain unclear. Our objective was to identify factors and develop machine learning models to predict which men presenting with ischemic priapism will require shunting. Read More

Blood Cells Mol Dis 2020 Apr 23;84:102438. Epub 2020 Apr 23.

Centre of Excellence for Sickle Cell Disease Research & Training, University of Abuja (CESRTA), Abuja, Federal Capital Territory, Nigeria. Electronic address:

Background/objective: Sickle cell disease (SCD) is a monogenic disease with multiple phenotypic expressions. Previous studies describing SCD clinical phenotypes in Nigeria were localized, with limited data, hence the need to understand how SCD varies across Nigeria.

Method: The Sickle Pan African Research Consortium (SPARCO) with a hub in Tanzania and collaborative sites in Tanzania, Ghana and Nigeria, is establishing a single patient-consented electronic database with a target of 13,000 SCD patients. Read More

BJU Int 2020 Jun 5. Epub 2020 Jun 5.

University of Texas Southwestern Medical Center, Department of Urology, Dallas, Texas, United States.

Objectives: To report our multi-institutional experience using penoscrotal decompression (PSD) for surgical treatment of prolonged ischemic priapism (PIP).

Materials And Methods: We retrospectively reviewed clinical records for PIP patients treated with PSD from 2017-2020. Priapisms were confirmed as ischemic based on clinical presentations and cavernosal blood gas abnormalities. Read More

Urol J 2020 05 28. Epub 2020 May 28.

Department of Urology, Haseki Traning and Research Hospital, Istanbul, Turkey.

Purpose: To analyze the predictive factors causing ischemic priapism following penile doppler ultrasonography (PDU) with intracavernosal papaverine injection Materials and methods: Medical records of 467 patients who underwent PDU examination following intracavernosal papaverine injection for erectile dysfunction (ED) between 2009 and 2017 were retrospectively reviewed. Patients with hematological disease anamnesis, patients taking phosphodiesterase-5 inhibitor, patients with intracavernosal injection therapy anamnesis and patients who underwent PDU with other intracavernosal vasodilator drugs other than papaverine were excluded from the study. The remaining 268 patients were divided into two groups as priapism (38 patients) and non-priapism (230 patients). Read More

Ned Tijdschr Tandheelkd 2020 Apr;127(4):237-243

The medicament afamelanotide is an analogue of endogenous ?-melanocyte-stimulating hormone. It promotes cutaneous pigmentation, providing protection from sunlight. In dermatology, afamelanotide seems to establish therapeutic results for polymorphic light eruption, solar urticaria, erythropoietic protoporphyria, Hailey-Hailey disease, vitiligo and acne vulgaris. Read More

Cureus 2020 Apr 18;12(4):e7721. Epub 2020 Apr 18.

Internal Medical, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.

Priapism is a serious but rare side effect of psychiatric medications. We report the case of a 28-year-old male who has been mentally stable for a year on a combination of sertraline, olanzapine, and quetiapine. Two weeks after he was started on topiramate, the patient experienced priapism that led to a medical admission and surgical intervention. Read More

Asian Spine J 2020 May 21. Epub 2020 May 21.

Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Shizuoka, Japan.

Study Design: Narrative review with a case illustration.

Purpose: The purpose of this study was to evaluate the pathogenesis and outcome of therapy for walking-evoked erection in patients with lumbar degenerative diseases.

Overview Of Literature: Cauda equina compression due to lumbar degenerative diseases rarely cause a walking-evoked erection; however, no review has been undertaken of walking-evoked erection in patients with lumbar degenerative diseases. Read More

Endocrinol Diabetes Nutr 2020 May 10. Epub 2020 May 10.

Servicio de Endocrinología y Nutrición, Hospital Clínic de Barcelona, Barcelona, España.

Expert Rev Hematol 2020 Jun 3;13(6):645-653. Epub 2020 May 3.

Department of Medicine, University of Pittsburgh , Pittsburgh, USA.

Introduction: In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are characteristically deformed and inflexible. Often breaking down in the circulation, they exhibit increased adhesive properties with the endothelium and activated neutrophils and platelets, increasing the risk of occlusion of the microcirculation. SCD is categorized into two sub-phenotypes: hyperhemolytic, associated with priapism, leg ulcers, pulmonary hypertension, and stroke, and high hemoglobin/viscosity, which may promote vaso-occlusion-associated pain, acute chest syndrome, and osteonecrosis. Read More

Childs Nerv Syst 2020 May 2. Epub 2020 May 2.

Servicio de Neurocirugía, Hospital Nacional de Niños, "Dr. Carlos Sáenz Herrera", San José, Costa Rica.

Stingray injuries are rare, mostly causing injuries to the lower extremities but occasionally fatal if there is direct puncture of the thorax, abdomen, or neck. Direct combined stingray injury to the central nervous system has not been reported in the literature. Herein we present the case of a 12-year-old boy who, while wading at the seashore of the Costa Rica's Pacific Ocean, sustained a combined oblique penetrating injury to the C6 vertebra caused by a Stingray. Read More

J Clin Psychopharmacol 2020 May/Jun;40(3):314-315

Istanbul University, Istanbul Medical Faculty, Child and Adolescent Psychiatry Department, Istanbul, Turkey

Einstein (Sao Paulo) 2020 22;18:eAO5070. Epub 2020 Apr 22.

Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.

Objective: To evaluate epidemiological aspects of priapism in patients with sickle cell disease, and these aspects impact on adult sexual function.

Methods: This was a cross-sectional study including individuals with sickle cell disease who were evaluated at a reference center for sickle cell. Participants completed a structured questionnaire about their sociodemographic characteristics and priapism events. Read More

Int J Impot Res 2020 Apr 20. Epub 2020 Apr 20.

Department of Urology, Dartmouth-Hitchcock Medical Center, Dartmouth Geisel School of Medicine, Lebanon, NH, USA.

Corporal fibrosis is a process that involves excessive deposition of scar tissue in response to infection, trauma, or ischemia. It does not occur merely as a result of previous IPP surgery. Excessive development of corporal fibrosis is certain after extraneous and disastrous events such as priapism or the removal of a device for infection. Read More

J Hematol 2019 Mar 30;8(1):11-16. Epub 2019 Mar 30.

MedStar Harbor Hospital, Baltimore, MD, USA.

Background: Sickle cell disease (SCD) affects 100,000 patients in the USA. However, no recent data was available for annual national trends in hospitalization rates, in-hospital mortality, hospital length of stay (LOS) and costs of SCD admissions due to its complications.

Methods: This study was conducted to study the trends of hospitalization rates, in-hospital mortality, LOS and hospital charges due to SCD-related complications in African American (AA) patients from 2004 to 2012 in the USA. Read More

Niger Postgrad Med J 2020 Apr-Jun;27(2):132-135

Department of Surgery; Department of Paediatrics, College of Medicine, Lagos State University, Ikeja, Lagos State, Nigeria.

Introduction: Paediatric urology is one of the subspecialities of urology, and in most climes, it is practised by the urologists and paediatric surgeons, and likewise in the Lagos State University Teaching Hospital (LASUTH). The urologists see and manage most of these cases in LASUTH. There has been no formal training in this subspeciality. Read More

Abdom Radiol (NY) 2020 Jul;45(7):1973-1989

Department of Radiology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200, Brussels, Belgium.

Erectile dysfunction (ED) is defined as the persistent inability to achieve and/or maintain an erection for a satisfactory sexual activity. It is secondary to several organic, psychogenic, and combined causes, and represents a serious health dilemma affecting both men and their partners. The diagnostic approach to erectile dysfunction has significantly changed in the last years with the advent of phosphodiesterase-5 (PDE5) inhibitors, and with the recognition that surgical treatment of both arterial insufficiency and penile venous leak have poor long-term clinical outcomes. Read More

Urology 2020 Jul 11;141:154-161. Epub 2020 Apr 11.

Department of Plastic Surgery, AGAPLESION Markus Hospital, Frankfurt, Germany.

Objective: To evaluate the outcome of a single-center series of penile reconstruction using the radial free forearm flap in rare indications.

Materials And Methods: From April 1993 until September 2016, 23 nontranssexual patients underwent phallic reconstruction by the use of a neuromicrovascular free radial forearm flap in our clinic. Patient-specific characteristics, surgical techniques, complications, and outcomes were retrospectively evaluated and interpreted. Read More

Cochrane Database Syst Rev 2020 04 6;4:CD004198. Epub 2020 Apr 6.

London North West University Healthcare NHS Trust, Haematology and Sickle Cell Centre, Central Middlesex Hospital, Acton Lane, London, UK, NW10 7NS.

Background: Sickle cell disease comprises a group of genetic haemoglobin disorders. The predominant symptom associated with sickle cell disease is pain resulting from the occlusion of small blood vessels by abnormally 'sickle-shaped' red blood cells. There are other complications, including chronic organ damage and prolonged painful erection of the penis, known as priapism. Read More

Am J Case Rep 2020 Apr 5;21:e920692. Epub 2020 Apr 5.

Pediatric Cardiology, Golisano Children's Hospital of Southwest Florida, Fort Myers, FL, USA.

BACKGROUND Priapism is rarely reported as a potential complication after the cardiac ablation procedure. We report the case of a teenager admitted for atrial flutter ablation who developed priapism following the procedure. CASE REPORT A 16-year-old male with episodic atrial flutter came to our hospital for an electrophysiological study and catheter ablation. Read More

Front Immunol 2020 13;11:454. Epub 2020 Mar 13.

Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team Vascular Biology and Red Blood Cell, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS), which polymerizes under deoxygenation, and induces the sickling of red blood cells (RBCs). Sickled RBCs are very fragile and rigid, and patients consequently become anemic and develop frequent and recurrent vaso-occlusive crises. However, it is now evident that SCD is not only a RBC rheological disease. Read More

Cureus 2020 Feb 18;12(2):e7032. Epub 2020 Feb 18.

Internal Medicine, Regional Medical Center Bayonet Point, Hudson, USA.

Abscess of the corpus cavernosum is a condition that occurs most commonly as a result of penile injection, priapism, sexually transmitted infections, and trauma. The diagnosis of corpus cavernosum abscess is made through imaging, typically computed tomography (CT) or ultrasound. The preferred method of treatment for corpus cavernosum abscess is incision, drainage, and antibiotic therapy. Read More

BMJ Case Rep 2020 Mar 24;13(3). Epub 2020 Mar 24.

Urology, Princess Alexandra Hospital Health Service District, Woolloongabba, Queensland, Australia.

Penile metastases from prostate cancer (PC) are rarely reported in the literature. Most commonly diagnosed due to presentation with malignant priapism and other urinary symptoms or from findings on clinical examination, prognosis has been reported to be poor. The authors outline a case of penile metastasis from advanced PC. Read More

J Ultrasound 2020 Mar 20. Epub 2020 Mar 20.

Department of General and Emergency Radiology, "Antonio Cardarelli" Hospital, Antonio Cardarelli St 9, 80131, Naples, Italy.

Priapism is a prolonged penile tumescence or erection unrelated to sexual stimulation that lasts more than 6 h. High-flow priapism is a rare condition usually due to a perineal trauma with the formation of an arterio-cavernosal fistula between a cavernosal artery and the lacunar spaces of the penis. High-flow priapism is usually diagnosed by clinical examination and color Doppler ultrasound, and the gold standard therapeutic management is represented by digital subtraction angiography. Read More

Expert Opin Ther Targets 2020 May 30;24(5):439-450. Epub 2020 Mar 30.

The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

: Priapism is prolonged penile erection in the absence of sexual arousal or desire and is a devastating condition affecting millions of patients with sickle cell disease (SCD) globally. Available drug treatments for SCD-related priapism remain limited and have been primarily reactive rather than preventive. Hence, there is an unmet need for new drug targets and pharmacologic therapies. Read More

Indian J Hematol Blood Transfus 2020 Jan 25;36(1):215-216. Epub 2019 Sep 25.

2Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi University, Delhi, India.

J Urol 2020 06 11;203(6):1054. Epub 2020 Mar 11.

J Urol 2020 06 11;203(6):1055-1056. Epub 2020 Mar 11.

J Urol 2020 06 11;203(6):1055. Epub 2020 Mar 11.

Ann Hematol 2020 May 5;99(5):947-953. Epub 2020 Mar 5.

Department of Clinical Pathology, School of Medical Sciences, State University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.

Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the expression of several inflammatory molecules. Therefore, it is conceivable that variations in levels of proinflammatory cytokines may act as a signaling of differential clinical course in SCA. Here, we evaluated the clinical impact of proinflammatory cytokines interleukin 1-β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8) in 79 patients with SCA, followed in a single reference center from northeastern Brazil. Read More

Res Rep Urol 2020 5;12:21-27. Epub 2020 Feb 5.

Department of Urology, Faculty of Medicine, Universitas Padjadjaran, General Hospital Hasan Sadikin, Bandung, Indonesia.

Introduction: The ischemic process in priapism can lead to displacement of normal tissue with fibrotic tissue, due to collagen deposition, and eventually leads to erectile dysfunction. Many studies have identified that the supernatant of adipose tissue-derived stem cells (ADSCs) significantly ameliorates fibrosis of different tissue, but limited attention has been paid to its efficacy on fibrosis of the corpora cavernosa.

Methods: A total of 22 Wistar rats divided into five groups, with two groups each consisting of five male wistar rats with priapism without human ADSC (hADSC) therapy (group I) and two other groups consisting of five rats with priapism, were given 10 cells' intracorporeal hADSC injection after 12 hours of penile clamping (group II) were euthanized after 2 and 4 weeks of observation. Read More

Transl Androl Urol 2020 Feb;9(1):87-92

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Background: The objective of this study is to review our 12-year experience with the 5-α reductase inhibitor dutasteride as a potential long-term treatment option for stuttering priapism. Dutasteride has a uniquely long half-life of 35 days which offers a theoretical advantage as a chronic therapy for management of stuttering priapism.

Methods: We retrospectively reviewed patients with stuttering priapism in our database from 2006-2018 treated with dutasteride. Read More

Transl Androl Urol 2020 Feb;9(1):38-42

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Impending distal cylinder tip extrusions (DCTE) make up approximately 5-33% of all inflatable penile prosthesis (IPP) reoperations. While there have been a few case reports of DCTE in patients with diabetes and trauma, the current literature regarding risk factors for DCTE is limited. In this study, we examined the long-term sequelae among a large cohort of IPP patients to identify clinical risk factors for impending DCTE. Read More

J Spine Surg 2019 Dec;5(4):596-600

Department of Neurosurgery, UCSF Medical Center, San Francisco, CA, USA.

Lumbar spinal stenosis (LSS) is characterized by narrowing of the central canal, lateral recesses, or foramina leading to compression of neural tissue. The clinical syndrome associated with LSS is usually neurogenic claudication, which often presents as lower back and extremity pain, numbness, and tingling upon ambulation. Autonomic dysfunction is rarely observed in patients with LSS; however, a subset of male patients has been reported to experience intermittent priapism associated with the onset of neurogenic claudication symptoms. Read More

Fertil Steril 2020 Jan;113(1):6-12

Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

This literature review presents two unusual and mystifying disorders of penile erection: painful nocturnal erections, alternatively termed sleep-related painful erections, and idiopathic stuttering priapism, a variant of recurrent ischemic priapism in which no cause is discernible. The disorders are closely related although they are distinct clinically and pathologically. The main subject areas of discussion are recognition, clinical evaluation and management although current concepts surrounding their causes and mechanisms are also addressed. Read More

West Afr J Med 2020 Jan-Mar;37(1):32-39

Department of Health Promotion and Education, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Priapism is a prolonged, painful penile erection common among males with Sickle Cell Disease (MWSCD) predisposing to erectile dysfunction (ED) when treatment is delayed. Unlike in women with sickle cell disease (SCD), there has been little attention to male reproductive health complications of SCD.

Objective: To investigate knowledge, experiences and coping mechanisms for priapism among MWSCD in Ibadan, Nigeria. Read More

Urol Ann 2020 Jan-Mar;12(1):103-105. Epub 2019 Nov 7.

Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

High-flow, or nonischemic, priapism occurs in <5% of observed clinical presentations of all priapism and is characterized by prolonged, painless erection in the context of pelvic and genitourinary trauma. While conservative management can be safely attempted for many cases of high-flow priapism (HFP), selective embolization is becoming the preferred approach as it allows for rapid resolution. We, herein, present a case of a 42-year-old male patient who presented with trauma-induced HFP treated with selective embolization and briefly review the current literature regarding the management of HFP. Read More

Bull Soc Pathol Exot 2019 ;112(4):213-219

Faculté des sciences de la santé, université Marien-Ngouabi de Brazzaville, Congo.

The experience of the adolescent with homozygous sickle-cell disease is influenced by several factors that differentiate it from the older child entirely dependent on his parents. The objective of this study was to describe the state of health and to assess the quality of follow-up and to identify the determinants of poor monitoring of adolescent sickle-cell followed in Brazzaville for an average of 12 ± 9.6 years, starting from a cross-sectional study carried out at the Brazzaville University Hospital from March to September 2016. Read More

Bull Soc Pathol Exot 2019 ;112(4):206-212

Service de pédiatrie nourrisson, CHU de Brazzaville, Brazzaville, Congo.

The objective of this study is to reduce the morbidity of children with homozygous sickle cell disease presenting severe forms. We have conducted a longitudinal study between November 2015 and September 2017 at the Brazzaville University Hospital. Children with sickle cell disease requiring treatment with hydroxyurea were included. Read More

Andrologia 2020 Apr 22;52(3):e13510. Epub 2020 Jan 22.

Department of Interventional Radiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Partial priapism is a rare disorder in literature and generally described as a contusion or thrombosis of the cavernous body of the penis secondary to blunt trauma. Because of the rarity of disease, there is not much information about the treatment. Conservative management with nonsteroidal anti-inflammatory drug is often applied treatment. Read More

Turk J Pediatr 2019 ;61(2):311-312

Departments of Pediatric Hematology Oncology, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara.

Sex Med Rev 2020 Jan 2. Epub 2020 Jan 2.

Department of Urology, University College London Hospital, 47 Wimpole St, London W1G 8SE, UK. Electronic address:

Introduction: Priapism is rare yet has the potential to inflict significant suffering on patients, often with lasting consequences such as erectile dysfunction, corporal muscle necrosis, and a loss of sexual function. Although rare, it is a pathology that has received little focus in the literature, particularly that caused by malignancy, and it is in this form that the long-term prognosis becomes particularly poor.

Aim: This review looks at malignant priapism in detail moving from the etiology and pathogenesis through investigations and management to provide an up-to-date picture. Read More

J Indian Assoc Pediatr Surg 2020 Jan-Feb;25(1):52-54. Epub 2019 Nov 27.

Department of Pediatrics, University College of Medical Sciences, New Delhi, India.

Priapism is an uncommon presentation in children and adults with a chronic myeloid type of leukemia. Its association is rarely found in an acute lymphoblastic type of leukemia (ALL). Timely management is important to prevent irreversible complications. Read More

Urol Case Rep 2020 Mar 16;29:101102. Epub 2019 Dec 16.

Department of Pediatric, Hasan Sadikin Hospital, Universitas Padjajaran, Indonesia.

Penile metastasis of adenocarcinoma of prostate is an extremely rare clinical entity and even less of such cases presenting with malignant priapism. Management of priapism with penile shunting is recommended in this case. No consensus beyond personal recommendation from other studies found in this case due to the relative rarity of the disease and the associated lack of data. Read More

Am J Emerg Med 2020 Apr 30;38(4):852.e1-852.e2. Epub 2019 Nov 30.

Health Science University, Antalya Training and Research Hospital, Department of Emergency Medicine, Antalya, Turkey. Electronic address:

Priapism is defined as a prolonged erection of the penis for at least 4 h without sexual stimulation. It may occur in all age groups. Drugs are the most common cause in adults. Read More

Radiol Med 2020 Mar 10;125(3):288-295. Epub 2019 Dec 10.

Interventional Radiology Department, AORN "A. Cardarelli", Via A. Cardarelli 9, 80131, Naples, Italy.

Purpose: High-flow priapism is an incomplete and painless persistent erection caused by trauma. Its diagnosis is performed thanks to clinic and imaging evaluation with detection of fistula/pseudoaneurysm in the cavernous tissue. This paper aims to retrospectively assess the efficacy and safety of superselective arterial embolization in patients with high-flow priapism. Read More

S D Med 2019 Oct;72(10):464-466

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Catastrophic antiphospholipid syndrome (CAPS) is a rare disorder characterized by acute, multi-system dysfunc- tion due to small-vessel thrombosis related to anti-phospholipid antibodies. Here we present an unusual case of CAPS presenting with genitourinary manifestations. A 72-year-old male developed a series of symptoms over the course of two weeks. Read More