221,023 results match your criteria Preventive veterinary medicine[Journal]


A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia.

Endoscopy 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, HSK Hospital, Wiesbaden, Germany.

Background:  Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification).

Methods:  The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module. Read More

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December 2018

Detecting moderate or complex congenital heart defects in adults from an electronic health records system.

J Am Med Inform Assoc 2018 Dec;25(12):1634-1642

Emory University School of Medicine, Atlanta, GA, USA.

Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.

Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More

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December 2018
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Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association.

Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Read More

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December 2018

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Am J Clin Nutr 2018 Dec;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Read More

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December 2018

Targeting cervical cancer campaigns on teenage high schoolers in resource-limited economies: lessons from an intervention study of Nigerian senior secondary school girls.

Fam Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Community Medicine and Primary Healthcare, Chukwuemeka Odumegwu Ojukwu University/University Teaching Hospital, Awka, Nigeria.

Background: Given the dearth of government-sponsored programmes, preventive lifestyles and practices are the realistic hopes for millions of women in developing countries against cervical cancer. Early interventions for teenage high school girls have been advocated recently, but evidence-base for sustainable activities at this demographic is lacking. This article reduces this gap by determining the impact of two cervical cancer education techniques. Read More

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December 2018

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

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December 2018

Age threshold for recommending higher protein intake to prevent age-related muscle weakness: A cross-sectional study in Japan.

PLoS One 2018 12;13(12):e0208169. Epub 2018 Dec 12.

Departments of Health and Social Behavior, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Although insufficient dietary protein intake is a known risk factor for age-related muscle weakness, the optimal age at which higher protein intake is required to prevent muscle weakness is yet to be determined. Using a population-based panel survey of community-dwelling people aged 50-75 years, this cross-sectional study aimed to find the age threshold at which a higher protein intake is associated with higher muscle strength. We utilized a dataset from the Japanese Study of Aging and Retirement conducted between 2007 and 2011. Read More

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December 2018

Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Antibiotic prescribing practices in secondary and tertiary hospitals in Shaanxi province, western China, 2013-2015.

PLoS One 2018 12;13(12):e0207229. Epub 2018 Dec 12.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Introduction: The irrational use of antibiotics is a major driver of antimicrobial resistance. This study aimed to explore how antibiotics were used in secondary and tertiary hospitals in Shaanxi Province, western China from 2013 to 2015.

Method: A retrospective study was conducted with a sample of 16 hospitals in Shaanxi Province (2 tertiary and 14 secondary hospitals; 8 public and 8 private hospitals) using a stratified random sampling method. Read More

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December 2018

Job Strain and Long-Term Sickness Absence from Work - a Ten-Year Prospective Study in German Working Population.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium (Mutambudzi); Department of Preventive Medicine & Community Health, University of Texas Medical Branch, Galveston, Texas (Mutambudzi); Stress Research Institute, Stockholm University, Stockholm, Sweden (Theorell); Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany (Li).

Objective: To examine the prospective associations between baseline job strain and ten-year cumulative incidence of long term sickness absence (LTSA) in the German workforce.

Methods: This study used longitudinal data from the 2001-2010 waves of The German Socio-Economic Panel (SOEP) (n = 9794). Kaplan-Meier survival curves and Cox proportional hazard regression models were used to examine the prospective association between job strain and incidence of LTSA. Read More

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December 2018

In Vivo Analysis of Urinary Stones With Dual-Energy Computed Tomography.

J Comput Assist Tomogr 2018 Dec 12. Epub 2018 Dec 12.

Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.

Objective: Formation mechanisms and treatment of the urinary stones are different, depending on their chemical structure. Therefore, determining the stone type plays a key role in planning treatment and preventive measures. Computed tomography (CT), with the use of dual-energy technology in recent years, has made it possible to do in vivo analysis of urinary stones. Read More

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December 2018

Engaging in the prevention of pressure injuries in spinal cord injury: A qualitative study of community-dwelling individuals' different styles of prevention in Switzerland.

J Spinal Cord Med 2018 Dec 12:1-10. Epub 2018 Dec 12.

a Department of Health Sciences and Health Policy , University of Lucerne and Swiss Paraplegic Research , Lucerne/Nottwil , Switzerland.

Context: Spinal cord injury (SCI) is a complex chronic condition with multiple self-management requirements and a high prevalence of complications. Pressure injuries (PIs) are among the most common ones and represent a frequent reason for re-hospitalization. This study aimed to identify styles of prevention that individuals with SCI adopt to deal with the risk of developing PIs. Read More

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December 2018

Biological Control of Pierce's Disease of Grape by an Endophytic Bacterium.

Phytopathology 2018 Dec 12:PHYTO07180245FI. Epub 2018 Dec 12.

Department of Plant and Microbial Biology, University of California, Berkeley 94720.

Effective preventive measures and therapies are lacking for control of Pierce's disease of grape caused by the xylem-colonizing bacterium Xylella fastidiosa responsible for serious losses in grape production. In this study we explored the potential for endophytic bacteria to alter the disease process. While most endophytic bacteria found within grape did not grow or multiply when inoculated into mature grape vines, Paraburkholderia phytofirmans strain PsJN achieved population sizes as large as 10 cells/g and moved 1 m or more within 4 weeks after inoculation into vines. Read More

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December 2018
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[The Need for Recovery Scale: French adaptation and validation.]

Sante Publique 2018 July August;30(4):445-454

Objectives: The study presents the French validation of the scale of Need for Recovery after work (Need for Recovery) as well as the average scores according to sex, age, occupation and branch of industry.

Method: A representative sample of the French employees completed a questionnaire made up of the Need for Recovery Scale, Perceived Stress Scale, Hospital Anxiety and Depression Scale and Maslach Burnout Inventory - General Survey. Analyses of internal consistency led us to withdraw an item from original scale; validity as well as discriminating quality were evaluated with the adequate analyses. Read More

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December 2018

TEMPORAL COMPARISON OF WHEEZING PREVALENCE IN THE FIRST YEAR OF LIFE IN SÃO PAULO: INTERNATIONAL STUDY OF WHEEZING IN INFANTS.

Rev Paul Pediatr 2018 Oct-Dec;36(4):445-450

Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Objective: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center.

Methods: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006. We divided the infants into wheezing and non-wheezing. Read More

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THE CHANGING TREND OF MORTALITY CAUSED BY GASTROINTESTINAL CANCERS IN IRAN DURING THE YEARS 2006-2010.

Arq Gastroenterol 2018 Jul-Sep;55(3):237-241

Shiraz University of Medical Sciences, Department of Bacteriology and Virology, Shiraz, Iran.

Background: Cancers are one of the most important causes of death in the world. According to their high incidence and mortality, gastrointestinal cancers have particular importance among other cancers.

Objective: Therefore, this study was conducted to investigate the mortality change trends of gastrointestinal cancers in Iran. Read More

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February 2018

[Association between excess weight and serum lipid alterations in adolescents].

Cien Saude Colet 2018 Dec;23(12):4055-4063

Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas. Campinas SP Brasil.

The study estimated the prevalence of serum lipid alterations among adolescents and investigated its association with excess weight and abdominal obesity. It involved a cross-sectional study with 525 adolescents from Piracicaba (São Paulo state). Anthropometric (body mass index, waist circumference and waist-height ratio) and biochemical information were obtained (total cholesterol and fractions, triglycerides). Read More

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December 2018

Molecular Characterization and Drug Susceptibility of Isolated from Cattle in Xinjiang, China.

Chin Med J (Engl) 2018 Dec;131(24):3017-3019

National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

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December 2018

The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Periodontology, Master of Science Program, Veiga de Almeida University, Rua Ibituruna 108, casa 3, sala 201, Tijuca, Rio de Janeiro, 20271-020, Brazil.

The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Read More

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December 2018

Oxytocin reactivity to an emotional challenge paradigm and its relation to social-cognitive functions in healthy volunteers.

J Neural Transm (Vienna) 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychiatry Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1-3, 44791, Bochum, Germany.

The neuropeptide oxytocin (OT) is known to be an important modulator of social cognition. It has been shown that lower OT plasma concentrations are linked to impairments in social cognition. Studies have also shown that intranasal OT may enhance social-cognitive abilities in healthy subjects. Read More

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December 2018

Probiotics for preventing postoperative infection in colorectal cancer patients: a systematic review and meta-analysis.

Int J Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

Center for Disease Prevention and Control of Beijing Military Region, Beijing, 100042, China.

Purpose: Postoperative infection has seriously affected the prognosis of cancer patients, while probiotics have been increasingly used to prevent postoperative infection in clinical practice. This study aimed to evaluate the preventive effect of probiotics on infection after colorectal cancer (CRC) surgery.

Methods: Related clinical trial reports were collected from Pubmed, Embase, Cochrane Library as well as China National Knowledge Infrastructure (CNKI) databases. Read More

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December 2018

Blindness and eye disease in a Tibetan region of China: findings from a Rapid Assessment of Avoidable Blindness survey.

BMJ Open Ophthalmol 2018 17;3(1):e000209. Epub 2018 Nov 17.

British Columbia Center for Epidemiology & International Ophthalmology and Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.

Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999.

Methods And Analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size. Read More

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November 2018

Association of Early Life Exposure to Phthalates With Obesity and Cardiometabolic Traits in Childhood: Sex Specific Associations.

Front Public Health 2018 27;6:327. Epub 2018 Nov 27.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age. Read More

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November 2018

The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana.

J Pharm (Cairo) 2018 14;2018:1784645. Epub 2018 Nov 14.

Department of Pharmaceutics, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.

Background: The study was undertaken to elicit the knowledge, views, and perceptions of key stakeholders on malaria, its bioburden, and treatment options, in order to ascertain the knowledge gabs and challenges, especially in the use of oral quinine in childhood malaria.

Methods: A cross-sectional survey was conducted using a well-structured Likert Scale and self-administered questionnaire. The principal site of the study was a government-run children's hospital located in the Ashiedu Keteke Sub-Metro of Accra. Read More

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November 2018
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Radiomics improves efficiency for differentiating subclinical pheochromocytoma from lipid-poor adenoma: a predictive, preventive and personalized medical approach in adrenal incidentalomas.

EPMA J 2018 Dec 21;9(4):421-429. Epub 2018 Sep 21.

7Department of Radiology, Keck Medical Center of USC, Los Angeles, CA USA.

Objectives: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors.

Patients And Methods: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Read More

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December 2018

Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach.

EPMA J 2018 Dec 12;9(4):403-419. Epub 2018 Nov 12.

1Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.

In contrast to the genetic component in mammary carcinogenesis, epigenetic alterations are particularly important for the development of sporadic breast cancer (BC) comprising over 90% of all BC cases worldwide. Most of the DNA methylation processes are physiological and essential for human cellular and tissue homeostasis, playing an important role in a number of key mechanisms. However, if dysregulated, DNA methylation contributes to pathological processes such as cancer development and progression. Read More

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December 2018

Predictive and individualized management of stroke-success story in Czech Republic.

EPMA J 2018 Dec 25;9(4):393-401. Epub 2018 Oct 25.

1Department of Neurology, Faculty of Medicine in Pilsen, Charles University, Husova 3, 301 66 Plzen, Czech Republic.

The model of centralized stroke care in the Czech Republic was created in 2010-2012 by Ministry of Health (MH) in cooperation with professional organization-Cerebrovascular Section of the Czech Neurological Society (CSCNS). It defines priorities of stroke care, stroke centers, triage of suspected stroke patients, stroke care quality indicators, their monitoring, and reporting. Thirteen complex cerebrovascular centers (CCC) provide sophisticated stroke care, including intravenous thrombolysis (IVT), mechanical thrombectomy (MTE), as well as other endovascular (stenting, coiling) and neurosurgical procedures. Read More

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December 2018
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In glaucoma patients, low blood pressure is accompanied by vascular dysregulation.

EPMA J 2018 Dec 12;9(4):387-391. Epub 2018 Nov 12.

Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4031 Basel, Switzerland.

Background: There are many risk factors contributing to glaucomatous optic neuropathy. Beside increased intraocular pressure, vascular factors play a prominent role, particularly low blood pressure (BP), and vascular dysregulation. Both of them are essential components of the Flammer syndrome. Read More

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December 2018

Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine.

EPMA J 2018 Dec 13;9(4):379-385. Epub 2018 Nov 13.

5Department of General and Clinical Psychology, Pavlov First Saint Petersburg State Medical University, 6/8 Lva Tolstogo Street, St. Petersburg, Russia.

This article centers on the relationship between psychological specifics of dental patients and their adherence to treatment. It describes clinical and personality specifics of periodontal patients and presents personality characteristics of patients with positive and negative dynamics of the therapy, as well as patients without periodontal diseases. The study findings highlight the importance of building confidential relationships with the patient and the need for a client-oriented approach to developing treatment plans and strategies for different types of dental patients. Read More

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December 2018

Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health.

EPMA J 2018 Dec 28;9(4):367-377. Epub 2018 Aug 28.

1School of Public Health, Taishan Medical University, 619 Changcheng Road, Taian, 271016 People's Republic of China.

Background: Suboptimal health status (SHS) is an intermediate health status between health and illness, a syndrome characterised by the perception of health complaints, general weakness and low energy. This study aimed to investigate the prevalence of SHS and the correlation between SHS and psychological symptoms among Chinese college students and to identify the SHS-related risk factors from the perspective of predictive, preventive and personalised medicine (PPPM).

Methods: A cross-sectional study was conducted among 4119 college students who were enrolled from Medical University and Vocational and Technical College in the eastern and western areas of China. Read More

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December 2018

The role of the personality traits and work characteristics in the prediction of the burnout syndrome among nurses-a new approach within predictive, preventive, and personalized medicine concept.

EPMA J 2018 Dec 25;9(4):355-365. Epub 2018 Oct 25.

1Transilvania University of Brasov, 29, Eroilor Street, 500036 Brasov, Romania.

Background: The burnout syndrome is characterized by emotional exhaustion, depersonalization, and lack of personal accomplishment. It was identified in some professional categories, the most often being affected those in public health services.

Objectives: This study mainly aims to identify and analyze the value of the personality traits and work characteristics as predictive factors for the occurrence of the burnout syndrome in nurses, under the new approach of predictive, preventive, and personalized medicine. Read More

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December 2018

Biobanks in Horizon 2020: sustainability and attractive perspectives.

EPMA J 2018 Dec 23;9(4):345-353. Epub 2018 Nov 23.

Department of Immunochemistry, University Hospital Pilsen, Edvarda Benese 1128/13, 305 99 Pilsen, CZ Czech Republic.

Biobanks have during last two decades gained an important role in the whole process of biomedical research and health care not only in Europe but also worldwide. Biobanks are one of the pillars in personalised medicine tackling all its aspects such as prevention, diagnosis, treatment and monitoring closely the specific characteristics of an individual patient. The current and future power of biobanks is the amount of samples of high-quality and related information available for current and future research of diseases, for optimising patients´ prevention, diagnosis, treatment and monitoring. Read More

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December 2018

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic.

Front Pharmacol 2018 27;9:1381. Epub 2018 Nov 27.

Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by mutations in the CF Transmembrane-Conductance Regulator () gene. Unrelenting airway disease begins in infancy and produces a steady deterioration in quality of life, ultimately leading to premature death. While life expectancy has improved, current treatments for CF are neither preventive nor curative. Read More

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November 2018

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects.

Front Pharmacol 2018 27;9:1374. Epub 2018 Nov 27.

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Cancer is still a severe threat to the health of people worldwide. Chemotherapy is one of main therapeutic approaches to combat cancer. However, chemotherapy only has a limited success with severe side effects, especially causing damage to normal tissues such as bone marrow, gastrointestine, heart, liver, renal, neuron, and auditory tissues, etc. Read More

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November 2018

Nurses' knowledge on pressure injury prevention: a systematic review and meta-analysis based on the Pressure Ulcer Knowledge Assessment Tool.

Clin Cosmet Investig Dermatol 2018 23;11:613-620. Epub 2018 Nov 23.

Department of Nursing, School of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran,

Introduction: Inadequate knowledge on pressure injury (PI) can have a detrimental effect on preventive care strategies. The aim of this study was to assess the overall knowledge of nurses on PI prevention based on their scores on the Pressure Ulcer Knowledge Assessment Tool (PUKAT) and its subscales in different settings.

Methods: In this systematic review and meta-analysis, databases including Web of Science, Science Direct, Google Scholar, PubMed, and Scopus were searched, using the following keywords: Pressure Ulcer, Pressure injury, Bedsore, Pressure Sore, Decubitus Ulcer, knowledge, and their possible combinations. Read More

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November 2018

Needs of older adults living in long-term care institutions: an observational study using Camberwell Assessment of Need for the Elderly.

Clin Interv Aging 2018 21;13:2389-2395. Epub 2018 Nov 21.

Laboratory of Neuropsychobiology, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: No comprehensive needs assessment is performed routinely in Poland.

Purpose: The goal of the study was to investigate the patterns of needs in older individuals living in long-term care institutions (LTCIs) using the Camberwell Assessment of Need for the Elderly (CANE) questionnaire, based on a previously published study protocol.

Participants And Methods: The study included 306 LTCI residents (age: ≥75 years) with the a Mini-Mental State Examination (MMSE) score of at least 10 points. Read More

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November 2018

Five-decade trajectories in body mass index in relation to dementia death: follow-up of 33,083 male Harvard University alumni.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.

Background: In prospective cohort studies, obesity has been linked with a lower risk of subsequent dementia. Reverse causality, whereby neurodegeneration preceding overt dementia symptoms may lower weight, is a possible explanation of these findings. To explore further the weight-dementia association we followed people from early adulthood, an age at which neurodegeneration has typically yet to begin. Read More

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December 2018

Author Correction: Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system.

Sci Data 2018 Dec 11;5(1). Epub 2018 Dec 11.

German Center for Neurodegenerative Diseases, Otfried-Müller Straße 23, Tübingen, 72076, Germany.

The authors regret that Luba M. Pardo was omitted in error from the author list of the original version of this Data Descriptor. This omission has now been corrected in the HTML and PDF versions. Read More

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December 2018

Artificial stone-associated silicosis in Belgium: response.

Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Thoracic Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.

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December 2018

Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: a diagnostic accuracy and cost-effectiveness study.

Gut 2018 Dec 11. Epub 2018 Dec 11.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, UK.

Objective: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services.

Design: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). Read More

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December 2018

The reproducibility of assessment of white spot lesions adjacent to orthodontic brackets, with a quantitative light induced fluorescence digital camera at different rotations of teeth - an in vitro study.

BMC Oral Health 2018 Dec 11;18(1):209. Epub 2018 Dec 11.

Department of preventive dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Background: A quantitative light-induced fluorescence digital (QLF-D) camera is able to assess demineralizations adjacent to orthodontic brackets. Rotations of teeth during and the presence of the orthodontic appliances may influence the longitudinal follow-up of such lesions over time.

Methods: Brackets were bonded on extracted teeth: 54 incisors and 31 canines. Read More

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December 2018

Association between quantitative varicella-zoster virus antibody levels and zoster reactivation in HIV-infected persons.

AIDS Res Ther 2018 Dec 11;15(1):25. Epub 2018 Dec 11.

Infectious Disease Service, San Antonio Military Medical Center, San Antonio, USA.

Background: Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons.

Objective: Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster.

Study Design: US Military HIV Natural History (NHS) participants with a zoster diagnosis at least 5 years after HIV diagnosis (n = 100) were included. Read More

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December 2018

Impact of vaccine delays at the 2, 4, 6 and 12 month visits on incomplete vaccination status by 24 months of age in Quebec, Canada.

BMC Public Health 2018 Dec 11;18(1):1364. Epub 2018 Dec 11.

Institut national de santé publique du Quebec, 2400 d'Estimauville Avenue, Quebec, G1E 7G9, Canada.

Background: Timeliness in the administration of recommended vaccines is often evaluated using vaccine delays and provides more information regarding the susceptibility of children to vaccine-preventable diseases compared with vaccine coverage at a given age. The importance of on-time administration of vaccines scheduled at the first visit is well documented, but data are scarce about the impact of vaccine delays at other visits on vaccination status by 24 months of age. Using vaccine delays for the first three doses of DTaP-containing vaccines and for the first dose of measles-containing vaccines as markers of timeliness at the 2, 4, 6 and 12 month visits, we estimated the proportion of incomplete vaccination status by 24 months of age attributable to a vaccine delay at each of these visits. Read More

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December 2018
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Ethnic inequalities and pathways to care in psychosis in England: a systematic review and meta-analysis.

BMC Med 2018 Dec 12;16(1):223. Epub 2018 Dec 12.

Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Background: As part of a national programme to tackle ethnic inequalities, we conducted a systematic review and meta-analysis of research on ethnic inequalities in pathways to care for adults with psychosis living in England and/or Wales.

Methods: Nine databases were searched from inception to 03.07. Read More

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December 2018

An overview of co-morbidities and the development of pressure ulcers among older adults.

BMC Geriatr 2018 Dec 11;18(1):305. Epub 2018 Dec 11.

Chairman of Geriatric Division Herzog Medical Center, Jerusalem, Israel.

Background: The prevalence of pressure ulcers particularly in the frail older adult population continues to be high and very costly especially in those suffering from chronic diseases and has brought a higher awareness to comprehensive, preventive and therapeutic measures for treatment of pressure ulcers. Internal risk factors highlighted by comorbidities play a crucial role in the pathogenesis of pressure ulcers.

Main Body: Focusing on the impact of common chronic diseases (comorbidities) in aging on pressure ulcers (e. Read More

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December 2018

Maternal dietary consumption of legumes, vegetables and fruit during pregnancy, does it protect against small for gestational age?

BMC Pregnancy Childbirth 2018 Dec 11;18(1):486. Epub 2018 Dec 11.

Department of Health Sciences, University of Jaen, Campus de Las Lagunillas s n Edificio B3, 23071, Jaén, Spain.

Background: Different diets during pregnancy might have an impact on the health, reflected in the birthweight of newborns. The consumption of fruits and vegetables during pregnancy and the relationship with newborn health status have been studied by several authors. However, these studies have shown inconsistent results. Read More

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December 2018

Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer's Disease: A Systematic Review.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):371-384. Epub 2018 Dec 11.

Department of Biomedical and NeuroMotor Sciences, Functional MR Unit, University of Bologna, Bologna,

Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. Read More

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December 2018