1,176 results match your criteria Prevention of Opportunistic Infections in Patients Infected With HIV


One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis.

N Engl J Med 2019 03;380(11):1001-1011

From the University of Nebraska Medical Center, Omaha (S.S., C.V.F.); Harvard T.H. Chan School of Public Health, Boston (R.R., J.L.-C., J.A.); Johns Hopkins University School of Medicine, Baltimore (A.G., E.N., R.E.C.), and Social and Scientific Systems, Silver Spring (L. Moran) - both in Maryland; University of California, San Diego, School of Medicine, La Jolla (C.A.B.); GHESKIO, Port-au-Prince, Haiti (M.A.J.J., P.S.); Asociación Civil Impacta Salud y Educación, Lima, Peru (J.R.L., J.V.); Botswana-Harvard AIDS Partnership, Gaborone, Botswana (A.O.-O., G.M.); Chiang Mai University, Chiang Mai, Thailand (K.S.); Helen Joseph Hospital, Johannesburg (N.M.), Perinatal HIV Research Unit, Soweto (L. Mohapi), and the University of Kwa-Zulu Natal, Durban (S.M.) - all in South Africa; Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro (R.O.S.E.); Johns Hopkins-Blantyre Clinical Trials Unit, Blantyre (P.B.), and the University of North Carolina-Lilongwe Clinical Research Site, Lilongwe (C.K.) - both in Malawi; the University of Zimbabwe, Harare (J.H.); and Kenya Medical Research Institute-Walter Reed Clinical Research Site, Nairobi (D.L.).

Background: Tuberculosis is the leading killer of patients with human immunodeficiency virus (HIV) infection. Preventive therapy is effective, but current regimens are limited by poor implementation and low completion rates.

Methods: We conducted a randomized, open-label, phase 3 noninferiority trial comparing the efficacy and safety of a 1-month regimen of daily rifapentine plus isoniazid (1-month group) with 9 months of isoniazid alone (9-month group) in HIV-infected patients who were living in areas of high tuberculosis prevalence or who had evidence of latent tuberculosis infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1806808DOI Listing

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.

N Engl J Med 2018 11;379(20):1915-1925

From the Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (G. Meintjes, C. Stek, L.B., F.T., C. Schutz, A.N., A.J., R.J.W.), the Department of Medicine (G. Meintjes, C. Stek, F.T., C. Schutz, R.J.W.), and the Division of Clinical Pharmacology, Department of Medicine (G. Maartens), University of Cape Town, Cape Town, South Africa; the Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium (C. Stek, J.B., R.R., H.L., R.C., L.L.); the Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland (F.T.); and the Department of Medicine, Imperial College London and the Francis Crick Institute, London (R.J.W.).

Background: Early initiation of antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected patients who have tuberculosis reduces mortality among patients with low CD4 counts, but it increases the risk of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS).

Methods: We conducted this randomized, double-blind, placebo-controlled trial to assess whether prophylactic prednisone can safely reduce the incidence of paradoxical tuberculosis-associated IRIS in patients at high risk for the syndrome. We enrolled HIV-infected patients who were initiating ART (and had not previously received ART), had started tuberculosis treatment within 30 days before initiating ART, and had a CD4 count of 100 cells or fewer per microliter. Read More

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1800762
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1800762DOI Listing
November 2018
34 Reads

Opportunistic ocular infections in the setting of HIV.

Curr Opin Ophthalmol 2018 Nov;29(6):558-565

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.

Purpose Of Review: The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients.

Recent Findings: Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICU.0000000000000531DOI Listing
November 2018
21 Reads

Epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Jul 19;60:e34. Epub 2018 Jul 19.

Universidade Federal de Goiás, Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Jataí, Goiás, Brazil.

Knowledge about epidemiological distribution patterns of HIV infection in different geographic regions is relevant to understand the dynamics of the disease in Brazil. This study aims to characterize the epidemiological and clinical profile of HIV-infected patients from Southwestern Goias State, from 2005 to 2015. A standardized questionnaire was used to collect clinical-epidemiological, virological, and immunological data from the medical records of all HIV-infected patients (n=539) who were followed at the regional reference center of Jatai, Goias State, Brazil, from 2005 to 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946201860034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056885PMC
July 2018
4 Reads

A Retrospective Study of Culture-confirmed Mycobacterial Infection among Hospitalized HIV-infected Patients in Beijing, China.

Biomed Environ Sci 2018 Jun;31(6):459-462

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China.

A retrospective analysis was performed in two major HIV/AIDS referral hospitals in Beijing to evaluate the prevalence of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections in HIV-infected patients. A total of 627 patients' data were reviewed, and 102 (16.3%) patients were diagnosed with culture-confirmed mycobacterial infection, including 84 with MTB, 16 with NTM, and 2 with both MTB and NTM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3967/bes2018.060DOI Listing
June 2018
27 Reads

Community-acquired bacterial pneumonia in adult HIV-infected patients.

Expert Rev Anti Infect Ther 2018 07 12;16(7):579-588. Epub 2018 Jul 12.

a Department of Pulmonary Medicine Institut Clinic del Tórax, Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) , University of Barcelona (UB) - SGR 911- Ciber de Enfermedades Respiratorias (Ciberes) , Barcelona , Spain.

Introduction: Despite active antiretroviral therapy (ART), community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected patients and incurs high health costs. Areas covered: This article reviews the most recent publications on bacterial CAP in the HIV-infected population, focusing on epidemiology, prognostic factors, microbial etiology, therapy, and prevention. The data discussed here were mainly obtained from a non-systematic review using Medline, and references from relevant articles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14787210.2018.1495560DOI Listing
July 2018
3 Reads

Magnitude of opportunistic diseases and their predictors among adult people living with HIV enrolled in care: national level cross sectional study, Ethiopia.

BMC Public Health 2018 Jul 3;18(1):820. Epub 2018 Jul 3.

School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Opportunistic diseases cause morbidity and mortality among human immunodeficiency virus (HIV) infected persons. There is dearth of evidence on the magnitude and predictors of opportunistic diseases among PLHIV in Ethiopia. This study was conducted to determine the magnitude and predictors of opportunistic diseases among adults enrolled in the national HIV/AIDS care and treatment services and generate information for program planning and medicine quantification in the country. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-018-5733-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029130PMC

Late presentation to HIV/AIDS care at the Douala general hospital, Cameroon: its associated factors, and consequences.

BMC Infect Dis 2018 07 3;18(1):298. Epub 2018 Jul 3.

Douala General Hospital, P.0. Box 4856, Douala, Cameroon.

Background: The introduction of anti-retroviral treatment (ART) has significantly reduced mortality and morbidity associated with HIV/AIDS. While treatment at early stages of the disease is related to a better prognosis, late presentation (LP) to care is harmful to the infected person, the society and is more costly. We aimed to describe late presentation to HIV care, its associated factors and consequences in patients followed up in a tertiary hospital in Cameroon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3204-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029364PMC
July 2018
15 Reads

Cost-Effectiveness Analysis of Early vs Late Diagnosis of HIV-Infected Patients in South Carolina.

South Med J 2018 06;111(6):355-358

From the University of South Carolina-Palmetto Health Richland, Columbia, and South Carolina Department of Health and Environmental Control, Columbia.

Objectives: It is anticipated that early diagnosis, linkage to care, initiation of antiretroviral therapy (ART), and retention in care would lead to reduced opportunistic infections, reduction in human immunodeficiency virus-related morbidity and mortality and reduced rates of HIV transmission. This would be expected to lead to a reduction in the lifetime cost of care (LCC). This study analyzed existing data to determine to what extent early-versus-late HIV diagnosis affects LCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14423/SMJ.0000000000000819DOI Listing
June 2018
1 Read

Dynamic changes of Th1/Th2/Th17 cytokines and human beta defensin 2 in HIV-infected patients with oral candidiasis during the first year of highly active anti-retroviral therapy.

Arch Oral Biol 2018 Aug 3;92:62-67. Epub 2018 May 3.

Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, China. Electronic address:

Objective: To investigate the change of Th1/Th2/Th17 cytokines and human beta defensin 2 (HBD-2) in HIV-infected patients with oral candidiasis (OC) and gather information about OC-specific immunity.

Design: During the 1st year of highly active anti-retroviral therapy (HAART), 25 HIV-infected patients were followed up at the baseline, 3rd, 6th, 12th month. At each visit, oral manifestations were examined; oral rinses were collected and cultured for Candida; peripheral venous blood was taken to determine CD4 + T cell counts and HIV RNA viral load (VL); both unstimulated whole saliva and peripheral venous blood were taken to determine cytokine (IL-4, IL-17(A/F), IFN-γ) and HBD-2 levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archoralbio.2018.05.003DOI Listing
August 2018
6 Reads

In Reply: Latent tuberculous infection testing among HIV-infected persons in clinical care.

Int J Tuberc Lung Dis 2018 04;22(4):468-469

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA , Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.17.0910-2DOI Listing
April 2018
4 Reads

Socio-economic status and risk of tuberculosis: a case-control study of HIV-infected patients in Asia.

Int J Tuberc Lung Dis 2018 02;22(2):179-186

The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Setting: Tuberculosis (TB) is the most common human immunodeficiency virus (HIV) related opportunistic infection and cause of acquired immune-deficiency syndrome related death. TB often affects those from a low socio-economic background.

Objective: To assess the socio-economic determinants of TB in HIV-infected patients in Asia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.17.0348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880624PMC
February 2018
5 Reads

Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: a global systematic review and meta-analysis.

Parasit Vectors 2018 01 9;11(1):28. Epub 2018 Jan 9.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, 730046, People's Republic of China.

Background: Diarrhea caused by opportunistic intestinal protozoa is a common problem in HIV infection. We aimed to establish the prevalence of Cryptosporidium, misrosporidia, and Isospora in HIV-infected people using a systematic review and meta-analysis, which is central to developing public policy and clinical services.

Methods: We searched PubMed, ScienceDirect, Google Scholar, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP databases for studies reporting Cryptosporidium, microsporidia, or Isospora infection in HIV-infected people. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-017-2558-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759777PMC
January 2018
12 Reads

Screening for active tuberculosis before isoniazid preventive therapy among HIV-infected West African adults.

Int J Tuberc Lung Dis 2017 12;21(12):1237-1244

Institut National de la Santé et de la Recherche Médicale, Unité 1219, Université de Bordeaux, Bordeaux, Institut de Santé Publique, d'Epidémiologie et de Développement, France; Programme PAC-CI, Centre Hospitalier Universitaire (CHU) de Treichville, Abidjan, Côte d'Ivoire.

Setting: TEMPRANO was a multicentre, open-label trial in which human immunodeficiency virus (HIV) infected adults with high CD4 counts were randomised into early or deferred antiretroviral therapy (ART) arms with or without 6-month isoniazid preventive therapy (IPT) in a setting where the World Health Organization (WHO) recommends IPT in HIV-infected patients. Despite the WHO recommendation, IPT coverage remains low due to fear of the presence of undiagnosed active TB before prescribing IPT, and the related risk of drug resistance.

Objective: To report the frequency of undiagnosed TB in patients enrolled for IPT and describe the results of a 1-month buffer period to avoid prescribing IPT for active TB cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.17.0016DOI Listing
December 2017
4 Reads

Most common oral manifestations in pediatric patients HIV positive and the effect of highly active antiretroviral therapy.

Cien Saude Colet 2018 Jan;23(1):115-122

Departamento de Odontologia II, Centro de Ciências da Saúde, Universidade Federal do Maranhão. Av. Portugueses s/n, Bacangá. 65000-000 São Luís MA Brasil.

This integrative literature review aims to identify the main oral lesions affecting pediatric patients with HIV, and describe the effect of highly active antiretroviral therapy (HAART) on these injuries, comparing it to antiretroviral therapy (ART). A search was conducted in PubMed and Scielo databases, following predetermined inclusion and exclusion criteria. 19 papers were selected and the main information on the prevalence and frequency of oral manifestations in HIV-positive pediatric patients and effect of therapy applied were extracted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1413-81232018231.19072015DOI Listing
January 2018
16 Reads

Treatment adherence in patients living with HIV/AIDS assisted at a specialized facility in Brazil.

Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):607-612

Programa de Pós-graduação Stricto Sensu em Odontologia Preventiva e Social, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista, Araçatuba, SP, Brasil.

Introduction: In the 1990s, Brazil adopted a public policy that allowed for universal, free access to antiretroviral therapy (ART). Since then, treatment adherence has become a new challenge for administrators of sexually transmitted disease/acquired immunodeficiency syndrome (STD/AIDS) policies. This study quantified adherence to ART and verified whether there is an association between sociodemographic variables and clinical/laboratory data in human immunodeficiency virus (HIV)-infected patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0266-2017DOI Listing
December 2017
6 Reads

[Treatment outcome, survival and their risk factors among new tuberculosis patients co-infected with HIV during the Ebola outbreak in Conakry].

Rev Epidemiol Sante Publique 2017 Nov 22;65(6):419-426. Epub 2017 Oct 22.

Service de pneumo-phtisiologie, hôpital national Ignace Deen, CHU de Conakry, Conakry, Guinée.

Background: Mortality among TB/HIV co-infected patients remains high in Africa. The study aimed to estimate survival and associated factors in a cohort of TB/HIV co-infected patients who started tuberculosis treatment during the Ebola outbreak in Conakry, Guinea.

Methods: A prospective cohort study was conducted from April 2014 to December 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.respe.2017.05.011DOI Listing
November 2017
1 Read

Myeloid Dendritic Cells Repress Human Cytomegalovirus Gene Expression and Spread by Releasing Interferon-Unrelated Soluble Antiviral Factors.

J Virol 2018 01 14;92(1). Epub 2017 Dec 14.

Immune Ageing and Chronic Infections Group, Helmholtz Centre for Infection Research, Braunschweig, Germany

Cytomegalovirus (CMV) is a betaherpesvirus that latently infects most adult humans worldwide and is a major cause of morbidity and mortality in immunocompromised hosts. Latent human CMV (HCMV) is believed to reside in precursors of myeloid-lineage leukocytes and monocytes, which give rise to macrophages and dendritic cells (DC). We report here that human monocyte-derived DC (mo-DC) suppress HCMV infection in coculture with infected fibroblast target cells in a manner dependent on the effector-to-target ratio. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.01138-17
Publisher Site
http://dx.doi.org/10.1128/JVI.01138-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730771PMC
January 2018
14 Reads

Inadequacy of High-Dose Fluconazole Monotherapy Among Cerebrospinal Fluid Cryptococcal Antigen (CrAg)-Positive Human Immunodeficiency Virus-Infected Persons in an Ethiopian CrAg Screening Program.

Clin Infect Dis 2017 Nov;65(12):2126-2129

Department of Medicine, University of Minnesota, Minneapolis.

A total of 817 human immunodeficiency virus-infected Ethiopians with CD4 <150 cells/mL underwent plasma cryptococcal antigen (CRAG) screening. CRAG prevalence was 6.2%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cix613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850618PMC
November 2017
9 Reads

Risk factors for mortality in patients with tuberculosis and HIV in Douala (Cameroon).

Med Sante Trop 2017 Aug;27(3):286-291

Université libre de Bruxelles (ULB), École de santé, Belgique.

Despite prevention efforts, and free treatment, TB-HIV co-infection still occurs in Cameroon. The objective of this work is to present the risk factors for mortality in patients co-infected with TB and HIV in Douala from 2009 to 2014. This transversal, analytic, and retrospective study took place from November 2014 to May 2015 in the Laquintinie Hospital in Douala. Read More

View Article

Download full-text PDF

Source
http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ms
Publisher Site
http://dx.doi.org/10.1684/mst.2017.0713DOI Listing
August 2017
1 Read

How I treat patients with HIV-related hematological malignancies using hematopoietic cell transplantation.

Blood 2017 11 7;130(18):1976-1984. Epub 2017 Sep 7.

Hematological Malignancies and Hematopoietic Stem Cell Transplantation Institute, City of Hope, Duarte, CA.

Hematopoietic cell transplantation (HCT) has now been shown to be safe and effective for selected HIV-infected patients with hematological malignancies. Autologous HCT is now the standard of care for patients with HIV-related lymphomas who otherwise meet standard transplant criteria. Limited data also support use of allogeneic HCT (alloHCT) in selected HIV-infected patients who meet standard transplant criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-04-551606DOI Listing
November 2017
6 Reads

Infectious complications in HIV-infected kidney transplant recipients.

Int J STD AIDS 2018 03 1;29(4):341-349. Epub 2017 Sep 1.

1 Renal Transplant Department, 26933 Pitié-Salpêtriere Hospital , Paris, France.

Renal transplantation is now a viable alternative for dialysis in HIV-infected patients who achieve good immunovirological control with current antiretroviral therapy regimens available. However, there are few studies that analyze the incidence of post-transplant infections in this population. In this study, a retrospective analysis of data files of 24 HIV-infected kidney transplant (KT) recipients was undertaken, matched to 21 non-infected controls. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0956462417726213
Publisher Site
http://dx.doi.org/10.1177/0956462417726213DOI Listing
March 2018
1 Read

Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy.

BMC Infect Dis 2017 07 25;17(1):517. Epub 2017 Jul 25.

Department for Infectious Disease Epidemiology, Robert Koch Institute (RKI), Seestr. 10, 13353, Berlin, Germany.

Background: Understanding the immune response to combination antiretroviral therapy (cART) is essential for a clear approach to tuberculosis (TB) preventive therapy. We investigated the immunological recovery in cART-treated HIV-infected patients developing TB compared to those who remained free of TB.

Methods: We extracted data of HIV-infected patients from a multicenter cohort for the HIV clinical surveillance in Germany. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-017-2627-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526303PMC
July 2017
12 Reads

Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa.

N Engl J Med 2017 07;377(3):233-245

From the University of Zimbabwe Clinical Research Center, Harare, Zimbabwe (J.H., M.B.-D., G.M., K.N.); Joint Clinical Research Center, Kampala (V.M., C.K., P.M.), Mbarara (A.L.), and Fort Portal (S. Kabahenda) - all in Uganda; Medical Research Council Clinical Trials Unit at University College London (A.J.S., S.L.P., A.G., M.J.T., A.S.W., D.M.G.), Wellcome Trust Centre for Clinical Tropical Medicine and Department of Paediatrics, Imperial College (K.M.), and Queen Mary University of London (A.J.P.), London, and the Centre for Health Economics, University of York, York (S.W.) - all in the United Kingdom; the Department of Medicine and Malawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, Malawi (J.M., S. Kaunda); and Moi University School of Medicine, Eldoret (A.S., M.K.), and the Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Program, Kilifi (C.A., K.M.) - both in Kenya.

Background: In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%.

Methods: In this factorial open-label trial conducted in Uganda, Zimbabwe, Malawi, and Kenya, we enrolled HIV-infected adults and children 5 years of age or older who had not received previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter. They underwent simultaneous randomization to receive enhanced antimicrobial prophylaxis or standard prophylaxis, adjunctive raltegravir or no raltegravir, and supplementary food or no supplementary food. Read More

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1615822
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1615822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603269PMC
July 2017
27 Reads

Assessment of isoniazid preventive therapy in the reduction of tuberculosis among ART patients in Arba Minch Hospital, Ethiopia.

Ther Clin Risk Manag 2017 24;13:361-366. Epub 2017 Mar 24.

Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Tuberculosis (TB) is the most frequent life-threatening opportunistic disease among people living with HIV and remains a leading cause of mortality, even among persons receiving antiretroviral therapy (ART). Isoniazid preventive therapy (IPT) and cotrimoxazole prophylaxis have been recommended for the benefit of HIV/AIDS-infected individuals to prevent opportunistic infections. The aim of this study was to assess IPT prophylaxis in the reduction of TB among ART patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S127765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373837PMC
March 2017
9 Reads

Primary Prophylaxis for Cryptococcosis With Fluconazole in Human Immunodeficiency Virus-Infected Patients With CD4 T-Cell Counts <100 Cells/µL and Receiving Antiretroviral Therapy.

Clin Infect Dis 2017 Apr;64(7):967-970

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A prospective observational cohort study was conducted in 302 human immunodeficiency virus-infected patients who had a CD4 T-cell count <100 cells/µL and negative serum cryptococcal antigen initiating antiretroviral therapy in a resource-limited setting. During 2-year follow-up, there were no differences of survival rates and occurrences of newly diagnosed cryptococcosis between patients with and without fluconazole for primary prophylaxis of cryptococcosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/cix036DOI Listing
April 2017
24 Reads

Health systems in the Republic of Congo: challenges and opportunities for implementing tuberculosis and HIV collaborative service, research, and training activities.

Int J Infect Dis 2017 Mar 27;56:62-67. Epub 2016 Oct 27.

Fondation Congolaise pour la Recherche Médicale, Cité OMS, villa D6, Djoué, Brazzaville, Republic of Congo; Faculty of Sciences and Techniques, University Marien Ngouabi, Brazzaville, Republic of Congo; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address:

The Republic of Congo is on the World Health Organization (WHO) list of 'high burden' countries for tuberculosis (TB) and HIV. TB is the leading cause of death among HIV-infected patients in the Republic of Congo. In this viewpoint, the available data on TB and HIV in the Republic of Congo are reviewed, and the gaps and bottlenecks that the National TB Control Program (NTCP) faces are discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2016.10.012DOI Listing
March 2017
8 Reads

Cost-effectiveness of CRAG-LFA screening for cryptococcal meningitis among people living with HIV in Uganda.

BMC Infect Dis 2017 03 23;17(1):225. Epub 2017 Mar 23.

Johns Hopkins University School of Medicine, 725 N. Wolfe St. PCTB building-224, Baltimore, MD, 21205, USA.

Background: Cryptococcal meningitis (CM) constitutes a significant source of mortality in resource-limited regions. Cryptococcal antigen (CRAG) can be detected in the blood before onset of meningitis. We sought to determine the cost-effectiveness of implementing CRAG screening using the recently developed CRAG lateral flow assay in Uganda compared to current practice without screening. Read More

View Article

Download full-text PDF

Source
http://bmcinfectdis.biomedcentral.com/articles/10.1186/s1287
Publisher Site
http://dx.doi.org/10.1186/s12879-017-2325-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364591PMC
March 2017
2 Reads

Association between enteric protozoan parasites and gastrointestinal illness among HIV- and tuberculosis-infected individuals in the Chowke district, southern Mozambique.

Acta Trop 2017 Jun 14;170:197-203. Epub 2017 Mar 14.

Department of Parasitology, Pharmacy Faculty, Valencia University, Av. Vicente Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain. Electronic address:

Human immune deficiency virus (HIV) and tuberculosis (TB) infections remain major public health issues globally, particularly in sub-Saharan Africa. Impairment of both cell-mediated and humoral immunity by HIV and/or TB infections may limit the host's defences against other pathogens, including the diarrheagenic protozoan Cryptosporidium spp., Giardia intestinalis, and Entamoeba histolytica. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2017.03.010DOI Listing
June 2017
18 Reads

Seroprevalence of among HIV Patients in Jahrom, Southern Iran.

Korean J Parasitol 2017 Feb 28;55(1):99-103. Epub 2017 Feb 28.

Department of Microbiology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

is an important opportunistic agent especially in immunocompromised hosts and can cause significant morbidity and mortality. Hence, detection and monitoring of anti- antibodies are of a great interest in HIV-infected patients. A study on the prevalence of toxoplasmosis and associated risk factors was carried out among HIV-infected patients in Jahrom, southern Iran. Read More

View Article

Download full-text PDF

Source
http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2017.55
Publisher Site
http://dx.doi.org/10.3347/kjp.2017.55.1.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365268PMC
February 2017
20 Reads
0.965 Impact Factor

An association between decreasing incidence of invasive non-typhoidal salmonellosis and increased use of antiretroviral therapy, Gauteng Province, South Africa, 2003-2013.

PLoS One 2017 6;12(3):e0173091. Epub 2017 Mar 6.

Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

Background: HIV-infected persons are at increased risk of opportunistic infections, including invasive nontyphoidal Salmonella (iNTS) infections; antiretroviral therapy (ART) reduces this risk. We explored changing iNTS incidence associated with increasing ART availability in South Africa.

Methods: Laboratory-based surveillance for iNTS was conducted in Gauteng Province, South Africa, with verification using the National Health Laboratory Service's Central Data Warehouse (CDW), between 2003 and 2013. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338796PMC
September 2017
11 Reads

Early use of corticosteroids in infants with a clinical diagnosis of Pneumocystis jiroveci pneumonia in Malawi: a double-blind, randomised clinical trial.

Paediatr Int Child Health 2017 May 1;37(2):121-128. Epub 2017 Feb 1.

a College of Medicine, University of Malawi , Blantyre , Malawi.

Background: Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in infants with vertically acquired HIV infection and the most common cause of death in HIV-infected infants.

Objectives: To determine whether early administration of adjuvant corticosteroids in addition to standard treatment reduces mortality in infants with vertically acquired HIV and clinically diagnosed PJP when co-infection with cytomegalovirus and other pathogens cannot be excluded.

Methods: A double-blind placebo-controlled trial of adjuvant prednisolone treatment in HIV-exposed infants aged 2-6 months admitted to Queen Elizabeth Central Hospital, Blantyre who were diagnosed clinically with PJP was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20469047.2016.1260891DOI Listing
May 2017
15 Reads

Concurrent Plasmodium infection, anemia and their correlates among newly diagnosed people living with HIV/AIDS in Northern Ethiopia.

Acta Trop 2017 May 21;169:8-13. Epub 2017 Jan 21.

Department of public health, College of Health Sciences, Bahir Dar University, P.o. Box: 75, Bahir Dar, Ethiopia.

The magnitude of concurrent malaria infection and the impact it has on hematological abnormalities, such as anemia in people living with HIV/AIDS, is not well studied in Ethiopian set up. In this cross sectional study, therefore, we assessed the prevalence of concurrent malaria infection and anemia among highly active anti-retroviral therapy (HAART) naive people living with HIV/AIDS between October, 2012 to May, 2013 in Northern Ethiopia. After obtaining consent, socio demographic, clinical, immunological and behavioural data was obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2017.01.007DOI Listing
May 2017
29 Reads
2 Citations
2.270 Impact Factor

Venous Thromboembolism Requiring Extended Anticoagulation Among HIV-Infected Patients in a Rural, Resource-Constrained Setting in Western Kenya.

Ann Pharmacother 2017 May 6;51(5):380-387. Epub 2017 Jan 6.

2 Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.

Background: HIV-infected patients are at an increased risk of developing venous thromboembolism (VTE), and minimal data are available to describe the need for extended treatment.

Objective: To evaluate the frequency of and determine predictive risk factors for extended anticoagulation of VTE in HIV-infected patients in rural, western Kenya.

Methods: A retrospective chart review was conducted at the Anticoagulation Monitoring Service affiliated with Moi Teaching and Referral Hospital and the Academic Model Providing Access to Healthcare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1060028016686106DOI Listing
May 2017
11 Reads

Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection.

Braz J Infect Dis 2017 Jan - Feb;21(1):42-50. Epub 2016 Nov 29.

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, Laboratório de Imunologia e Epigenética, São Paulo, SP, Brazil. Electronic address:

Objectives: Three decades after HIV recognition and its association with AIDS development, many advances have emerged - especially related to prevention and treatment. Undoubtedly, the development of Highly Active Antiretroviral Therapy (HAART) dramatically changed the future of the syndrome that we know today. In the present study, we evaluate the impact of Highly Active Antiretroviral Therapy on macrophage function and its relevance to HIV pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjid.2016.10.004DOI Listing
August 2017
11 Reads

Cardiac Disease Associated with Human Immunodeficiency Virus Infection.

Cardiol Clin 2017 Feb;35(1):59-70

Feinberg School of Medicine, Northwestern University, 420 East Superior Street, Chicago, IL 60611, USA.

Over the last 2 decades human immunodeficiency virus (HIV) infection has become a chronic disease requiring long-term management. Aging, antiretroviral therapy, chronic inflammation, and several other factors contribute to the increased risk of cardiovascular disease in patients infected with HIV. In low-income and middle-income countries where antiretroviral therapy access is limited, cardiac disease is most commonly related to opportunistic infections and end-stage manifestations of HIV/acquired immunodeficiency syndrome, including HIV-associated cardiomyopathy, pericarditis, and pulmonary arterial hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccl.2016.09.003DOI Listing
February 2017
30 Reads

Prevalence and determinants of HIV in tuberculosis patients in Wuxi City, Jiangsu province, China: a cross-sectional study.

Int J STD AIDS 2016 11 18;27(13):1204-1212. Epub 2015 Oct 18.

Department of Medical affairs, the Lixin People's Hospital, Bozhou, Anhui, P.R. China.

At least one-third of the 34 million people living with human immunodeficiency virus (HIV) worldwide are infected with latent tuberculosis (TB). The aim of this study was to determine the rate of HIV infection in TB patients and its determinants in Wuxi City, China. TB patients attending health institutions (12 selected sites) for TB diagnosis and treatment were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0956462415612618DOI Listing
November 2016
1 Read

Asymptomatic cryptococcal antigen prevalence detected by lateral flow assay in hospitalised HIV-infected patients in São Paulo, Brazil.

Trop Med Int Health 2016 12 24;21(12):1539-1544. Epub 2016 Oct 24.

University of Minnesota, Minneapolis, MN, USA.

Objective: To determine the prevalence of asymptomatic cryptococcal antigen (CRAG) using lateral flow assay (LFA) in hospitalised HIV-infected patients with CD4 counts <200 cells/μl.

Methods: Hospitalised HIV-infected patients were prospectively recruited at Instituto de Infectologia Emilio Ribas, a tertiary referral hospital to HIV-infected patients serving the São Paulo State, Brazil. All patients were >18 years old without prior cryptococcal meningitis, without clinical suspicion of cryptococcal meningitis, regardless of antiretroviral (ART) status, and with CD4 counts <200 cells/μl. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tmi.12790DOI Listing
December 2016
30 Reads

The use of mannitol in HIV-infected patients with symptomatic cryptococcal meningitis.

Drug Discov Ther 2017 Jan 11;10(6):329-333. Epub 2016 Oct 11.

Department of Infectious Diseases, the Second Affiliated Hospital of Medical School of the Southeast University.

Cryptococcal meningitis (CM) is a common opportunistic infection with a high mortality rate in human immunodeficiency virus (HIV)-infected patients. It is unclear whether mannitol could be used to manage neurological symptoms in HIV-associated CM. Here, we retrospectively analyzed the clinical data of 33 patients with HIV-associated symptomatic CM at our hospital where mannitol was used to relieve neurologic symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5582/ddt.2016.01054DOI Listing
January 2017
9 Reads

Predictors of Treatment Failure among Adult Antiretroviral Treatment (ART) Clients in Bale Zone Hospitals, South Eastern Ethiopia.

PLoS One 2016 7;11(10):e0164299. Epub 2016 Oct 7.

Department of Nursing, College of Medicine and Health Sciences, Madda Walabu University, Bale Goba, Ethiopia.

Background: Treatment failure defined as progression of disease after initiation of ART or when the anti-HIV medications can't control the infection. One of the major concerns over the rapid scaling up of ART is the emergence and transmission of HIV drug resistant strains at the population level due to treatment failure. This could lead to the failure of basic ART programs. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164299PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055376PMC
June 2017
33 Reads

Patterns and trends in mortality among HIV-infected and HIV-uninfected patients in a major Internal Medicine Unit in Yaoundé, Cameroon: a retrospective cohort study.

JRSM Open 2016 Sep 1;7(9):2054270416654859. Epub 2016 Sep 1.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, PO Box 1364, Yaoundé, Cameroon; Internal Medicine Unit, Yaoundé University Hospital Centre, PO Box 4806, Yaoundé, Cameroon.

Objective: To describe the trends in mortality and the spectrum of disease in HIV-infected and -uninfected inpatients in a population in Yaoundé.

Design: A retrospective study.

Setting: Internal Medicine Unit, University Hospital Centre, Yaoundé, Cameroon. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2054270416654859
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011308PMC
http://dx.doi.org/10.1177/2054270416654859DOI Listing
September 2016
19 Reads

[Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin].

J Mycol Med 2016 Dec 15;26(4):391-397. Epub 2016 Sep 15.

Laboratoire de parasitologie-mycologie, centre national hospitalier universitaire Koutoukou Maga (CNHU/HKM), 03BP386, Cotonou, Benin.

Objective: Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines.

Patients And Methods: This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mycmed.2016.08.007DOI Listing
December 2016
4 Reads

Prescription of Pneumocystis Jiroveci Pneumonia Prophylaxis in HIV-Infected Patients.

J Int Assoc Provid AIDS Care 2016 11 14;15(6):455-458. Epub 2016 Sep 14.

Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, GA, USA.

The US treatment guidelines recommend Pneumocystis jiroveci pneumonia (PCP) prophylaxis for all HIV-infected persons with a CD4 count <200 cells/mm (ie, eligible for PCP prophylaxis). However, some studies suggest PCP prophylaxis may be unnecessary in virally suppressed patients. Using national data of HIV-infected adults receiving medical care in the United States during 2009 to 2012, the authors assessed the weighted percentage of eligible patients who were prescribed PCP prophylaxis and the independent association between PCP prophylaxis prescription and viral suppression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2325957416667486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310212PMC
November 2016
16 Reads

A SOA-Based Solution to Monitor Vaccination Coverage Among HIV-Infected Patients in Liguria.

Stud Health Technol Inform 2016 ;228:327-31

Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via Opera Pia 13, 16145 Genoa, Italy.

Vaccination in HIV-infected patients constitutes an essential tool in the prevention of the most common infectious diseases. The Ligurian Vaccination in HIV Program is a proposed vaccination schedule specifically dedicated to this risk group. Selective strategies are proposed within this program, employing ICT (Information and Communication) tools to identify this susceptible target group, to monitor immunization coverage over time and to manage failures and defaulting. Read More

View Article

Download full-text PDF

Source
April 2017
3 Reads

Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010.

J Infect Dis 2016 09 18;214(6):862-72. Epub 2016 Apr 18.

Divisions of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada.

Methods: We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiw085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996145PMC
September 2016
19 Reads

ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients.

J Antimicrob Chemother 2016 09 12;71(9):2397-404. Epub 2016 May 12.

Department of Haematology, Henri Mondor Teaching Hospital, Assistance Publique-Hôpitaux de Paris, and Université Paris-Est-Créteil, Créteil, France

The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice for the primary prophylaxis of PCP in adults ( A-II: ) and children ( A-I: ) and should be given during the entire period at risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkw157DOI Listing
September 2016
42 Reads
5.313 Impact Factor

Pneumocystis jirovecii pneumonia: still a concern in patients with haematological malignancies and stem cell transplant recipients.

J Antimicrob Chemother 2016 09 12;71(9):2379-85. Epub 2016 May 12.

Department of Haematology, Acute Leukaemia and Stem Cell Transplantation Unit, University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium.

Pneumocystis jirovecii can cause life-threatening pneumonia following treatment for haematological malignancies or after HSCT. The mortality rate of P. jirovecii pneumonia (PCP) in these patients is 30%-60%, especially after HSCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jac/dkw155DOI Listing
September 2016
18 Reads
5.313 Impact Factor

Forecast analysis of any opportunistic infection among HIV positive individuals on antiretroviral therapy in Uganda.

BMC Public Health 2016 08 11;16(1):766. Epub 2016 Aug 11.

Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Predicting future prevalence of any opportunistic infection (OI) among persons infected with the human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) in resource poor settings is important for proper planning, advocacy and resource allocation. We conducted a study to forecast 5-years prevalence of any OI among HIV-infected individuals on HAART in Uganda.

Methods: Monthly observational data collected over a 10-years period (2004-2013) by the AIDS support organization (TASO) in Uganda were used to forecast 5-years annual prevalence of any OI covering the period 2014-2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-016-3455-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982438PMC
August 2016
7 Reads

Human Immunodeficiency Virus as a Chronic Disease: Evaluation and Management of Nonacquired Immune Deficiency Syndrome-Defining Conditions.

Open Forum Infect Dis 2016 Apr 12;3(2):ofw097. Epub 2016 May 12.

Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria and Universidad de Alcalá , Madrid.

In the modern antiretroviral therapy (ART) era, motivated people living with human immunodeficiency virus (HIV) who have access to therapy are expected to maintain viral suppression indefinitely and to receive treatment for decades. Hence, the current clinical scenario has dramatically shifted since the early 1980s, from treatment and prevention of opportunistic infections and palliative care to a new scenario in which most HIV specialists focus on HIV primary care, ie, the follow up of stable patients, surveillance of long-term toxicities, and screening and prevention of age-related conditions. The median age of HIV-infected adults on ART is progressively increasing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofw097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943534PMC
April 2016
12 Reads

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel.

JAMA 2016 Jul;316(2):191-210

University of California San Francisco.

Importance: New data and therapeutic options warrant updated recommendations for the use of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults.

Objective: To provide updated recommendations for the use of antiretroviral therapy in adults (aged ≥18 years) with established HIV infection, including when to start treatment, initial regimens, and changing regimens, along with recommendations for using ARVs for preventing HIV among those at risk, including preexposure and postexposure prophylaxis.

Evidence Review: A panel of experts in HIV research and patient care convened by the International Antiviral Society-USA reviewed data published in peer-reviewed journals, presented by regulatory agencies, or presented as conference abstracts at peer-reviewed scientific conferences since the 2014 report, for new data or evidence that would change previous recommendations or their ratings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2016.8900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012643PMC
July 2016
57 Reads
95 Citations
35.290 Impact Factor