1,613,903 results match your criteria Prevention of Opportunistic Infections in Patients Infected With HIV


Strategies for the management of invasive fungal infections due to filamentous fungi in high-risk hemato-oncological patients.

Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.

Carlos Vallejo, Hospital Donostia, Begiristain Doktorea Pasealekua, 109, 20014 Donostia, Gipuzkoa, Spain.

Objective: In recent years, the introduction of new antifungals for the prevention of invasive fungal infections (IFIs) in hemato- oncological patients, particularly extended-spectrum azoles, has led to a change in the diagnostic and therapeutic strategies for established or suspected breakthrough IFI. The aim of the study was to identify the diagnostic and therapeutic strategies used in the management of IFIs in hemato-oncological patients in Spain, and to assess compliance with the recommendations of the consensus documents and clinical practice guidelines.

Methods: An online, anonymous, cross-sectional survey was conducted between January and September 2016 involving 137 specialists from third-level hospitals in Spain with Departments of Hematology that regularly deal with IFIs. Read More

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December 2018

[Introduction: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope.Methods: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al. Carey’s framework was used to apply proportionate universalism in order to analyse its action on these inequalities, adopting a contextualised and holistic approach with regard to regional and national public policy. The results showed that the intervention focused on targeted actions, but may have broader applications. The intervention strategy shifts between closing the inequality gap and levelling up the social gradient. However, analysis of this type of intervention using the proportionate universalism framework may lead to a revised view of the effects of the intervention on social inequalities in health.Results: Implementing health-equity focused interventions remains a challenge for each institution, including Regional Health Agencies. However, research on hospital-based preventive interventions highlights contrasting results in terms of social gradient, depending on whether the intervention is considered in isolation or in its broader context.Discussion].

Sante Publique 2018 Sep;S2(HS2):25-32

Introduction: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope.

Methods: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al. Read More

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September 2018

Universalisme proportionné : vers une « égalité réelle » de la prévention en France.

Sante Publique 2018 Sep;S2(HS2):13-24

Although their design may feature a considerable amount of universalism, prevention strategies often produce results that are socially and/or spatially differentiated. This differentiation process can induce social or territorial gradients of access to and/or effectiveness of prevention and, in turn, worsen health inequalities. This process also accentuates the gap between the principles of certain public policies and their practical implementation, raising the question of the real benefit of these policies for beneficiaries. Read More

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September 2018
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Transition of Children with Perinatally Acquired HIV-Infection into Adulthood: Social Outcome and Quality of Life.

Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Asha Kirana Hospital, Hebbal Industrial Housing Area, Ring Road, Hebbal, Mysore 570016, Karnataka, India.

Objectives: In India, access to free anti-retroviral therapy has improved the survival of perinatally human immunodeficiency virus (HIV) infected children resulting in the transition of many such children to adulthood. This study aims to understand the social-outcomes and quality of life (QOL) among these adults.

Methods: This cross-sectional study was conducted in two tertiary HIV care centers in south India. Read More

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December 2018

Violence in the Early Bronze Age. Diagnosis of skull lesions using anthropological, taphonomic and scanning electron microscopy techniques.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Humanities, University of Ferrara, Ferrara, Italy.

In this paper we present the study of a skull belonging to a young male from the Italian Bronze Age showing three perimortem injuries on the frontal and parietal bones; the peculiarity of the frontal injury is represented by its singular shape, which may be indicative of the weapon that caused the lesion. The aim of the present study is to examine the traumatic evidence in relation to possible etiological factors, in order to attempt to establish if the lesion occurred peri or post-mortem, and to evaluate if these traumatic injuries could be interpreted as an evidence of interpersonal violence, by combining anthropological, taphonomic and ESEM investigations. The combination of multidisciplinary methods of study can provide important new insights into inter-personal violence. Read More

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December 2018

Optimizing the removal of nitrate from aqueous solutions via reduced graphite oxide-supported nZVI: synthesis, characterization, kinetics, and reduction mechanism.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Civil and Environment Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.

Graphene has been considered an ideal absorbent and excellent carrier for nanoparticles. Reduced graphite oxide (rGO)-supported nanoscale zero-valent iron (nZVI@rGO) is an effective material for removing nitrate from water. nZVI@rGO nanocomposites were prepared by a liquid-phase reduction method and then applied for nitrate-nitrogen (NO-N) removal in aqueous solution under anaerobic conditions. Read More

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December 2018

Effects of Migration on Risky Sexual Behavior and HIV Acquisition in South Africa: A Systematic Review and Meta-analysis, 2000-2017.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

Africa Health Research Institute, K-RITH Tower Building, 719 Umbilo Road, Congella, Private Bag X7, Durban, South Africa.

While human mobility has been implicated in fueling the HIV epidemic in South Africa, the link between migration and HIV has not been systematically reviewed and quantified. We conducted a systematic review of the role of migration in HIV risk acquisition and sexual behaviour based on 29 studies published between 2000 and 2017. Furthermore, we performed a meta-analysis of the association between migration and HIV risk acquisition in four of the studies that used HIV incidence as an outcome measure. Read More

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December 2018

Depression, ART Adherence, and Receipt of Case Management Services by Adults with HIV in North Carolina, Medical Monitoring Project, 2009-2013.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

North Carolina Department of Health and Human Services, Division of Public Health, Communicable Disease Branch, Raleigh, NC, 27603, USA.

Depression among persons with HIV is associated with antiretroviral therapy (ART) interruption and discontinuation, virological failure, and poor clinical and survival outcomes. Case management services can address needs for emotional counseling and other supportive services to facilitate HIV care engagement. Using 2009-2013 North Carolina Medical Monitoring Project data from 910 persons engaged in HIV care, we estimated associations of case management utilization with "probable current depression" and with 100% ART dose adherence. Read More

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December 2018

Increasing trends in in situ breast cancer incidence in a region with no population-based mammographic screening program: results from Zurich, Switzerland 2003-2014.

J Cancer Res Clin Oncol 2018 Dec 13. Epub 2018 Dec 13.

Division of Chronic Disease Epidemiology, Institute for Epidemiology, Biostatistics and Prevention, University of Zurich, Hirschengraben 82, 8001, Zurich, Switzerland.

Purpose: Increase in in situ breast cancer (BCIS) incidence has been reported across Europe and the USA. However, little is known about the trends in BCIS incidence in regions without population-based mammographic screening programs. We set out to investigate these trends in Zurich, Switzerland, where only opportunistic mammographic screening exists. Read More

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December 2018

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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December 2018

Hypothesis: ubiquitous circadian disruption can cause cancer.

Eur J Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of Cologne, Cologne, Germany.

Circadian disruption (CD) was implicated in chains of cancer causation when the International Agency for Research on Cancer classified shift-work involving circadian disruption as probably carcinogenic in 2007. In the following decade, epidemiological studies into causal concepts associated with circadian disruption were inconclusive. Unappreciated complexity with an exclusive focus on shift-work, light-at-night, sleep, and melatonin in regard to circadian disruption may be accountable. Read More

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December 2018

Follow-up efficacy of physical exercise interventions on fall incidence and fall risk in healthy older adults: a systematic review and meta-analysis.

Sports Med Open 2018 Dec 13;4(1):56. Epub 2018 Dec 13.

Department of Training and Movement Sciences, Humboldt-Universität zu Berlin, Philippstr. 13, Haus 11, 10115, Berlin, Germany.

Background: The risk of falling and associated injuries increases with age. Therefore, the prevention of falls is a key priority in geriatrics and is particularly based on physical exercising, aiming to improve the age-related decline in motor performance, which is crucial in response to postural threats. Although the benefits and specifications of effective exercise programs have been well documented in pre-post design studies, that is during the treatment, the definitive retention and transfer of these fall-related exercise benefits to the daily life fall risk during follow-up periods remains largely unclear. Read More

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December 2018

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Diabetologia 2018 Dec 13. Epub 2018 Dec 13.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues for preventing chronic kidney disease and end-stage renal disease, which are highly prevalent in individuals with diabetes. Efforts to identify genetic susceptibility variants for albuminuria have so far been limited, with the majority of studies focusing on common variants.

Methods: We performed an exome-wide association study to identify coding variants in a two-stage (discovery and replication) approach. Read More

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December 2018

Building a network for multicenter, prospective research of central nervous system infections in South America: Process and lessons learned.

eNeurologicalSci 2018 Dec 4;13:63-69. Epub 2018 Jul 4.

Hospital Emergencias Pediatricas, Lima, Peru.

Multicenter collaborative networks are essential for advancing research and improving clinical care for a variety of conditions. Research networks are particularly important for central nervous system infections, which remain difficult to study due to their sporadic occurrence and requirement for collection and testing of cerebrospinal fluid. Establishment of long-term research networks in resource-limited areas also facilitates diagnostic capacity building, surveillance for emerging pathogens, and provision of appropriate treatment where needed. Read More

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December 2018

Ideal Cardiovascular Health and Cognitive Test Performance: Testing a Modified Index of Life's Simple 7 Among Older Chinese Adults.

Front Public Health 2018 28;6:352. Epub 2018 Nov 28.

Department of Anthropology, Dartmouth College, Hanover, NH, United States.

Evidence suggests that cognitive decline in older adults is influenced by cardiovascular health (CVH), with metabolic and vascular mechanisms hypothesized to underlie the etiology of cognitive impairment. Research in high-income nations suggests that improved CVH is linked with decreased cognitive impairment risk, but it is unclear if this pattern is evident in low-income countries. Nationally-representative data collected in China were drawn from the World Health Organization's Study on global AGing and adult health Wave 1 (2007-2010; = 11,295). Read More

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November 2018

Effect of menstruation on girls and their schooling, and facilitators of menstrual hygiene management in schools: surveys in government schools in three states in India, 2015.

J Glob Health 2019 Jun;9(1):010408

Department of Clinical Sciences, Liverpool School of Tropical Medicine (LSTM), Liverpool, UK.

Background: Lack of menstrual knowledge, poor access to sanitary products and a non-facilitating school environment can make it difficult for girls to attend school. In India, interventions have been developed to reduce the burden of menstruation for school girls by government and non-governmental organizations (NGOs). We sought to identify challenges related to menstruation, and facilitators of menstrual management in schools in three states in India. Read More

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The relationship between the houseboundedness and frailty of community-dwelling elderly persons.

J Rural Med 2018 Nov 29;13(2):141-150. Epub 2018 Nov 29.

Uji City, Kyoto Prefecture, Japan.

This study aimed to verify whether the incidence of frailty in elderly individuals is higher among those who are housebound than those who are not. This study found no correlation between elderly people's houseboundedeness and physical, mental, social, and overall frailty. However, the Tilburg Frailty Indicator (TFI) frailty score and grip strength value were higher in non-housebound elderly persons than in housebound elderly ones. Read More

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November 2018

The possible different roles of denosumab in prevention and cure breast cancer bone metastases: A 'hypothesis-generator' study from clinical practice.

Oncol Lett 2018 Dec 10;16(6):7195-7203. Epub 2018 Oct 10.

Medical Oncology, St. Salvatore Hospital, I-67100 L'Aquila, Italy.

The most frequent site of recurrence in breast cancer (BC) is the bone, particularly in patients with 'luminal-like' disease. Denosumab has been shown to prevent aromatase inhibitors (AIs) induced bone resorption in postmenopausal early BC patients and reduce skeletal-related events (SREs) in bone metastatic breast cancer (BMBC). A 'real life' analysis of 90 BMBC patients treated with denosumab was performed. Read More

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December 2018

Dynamic changes and diagnostic and prognostic significance of serum PCT, hs-CRP and s-100 protein in central nervous system infection.

Exp Ther Med 2018 Dec 16;16(6):5156-5160. Epub 2018 Oct 16.

Inspection Department, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.

The aim of the study was to analyze the dynamic changes and diagnostic and prognostic significance of serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and s-100 protein in central nervous system infection. A total of 110 patients diagnosed with central nervous system infection in Department of Neurology in the People's Hospital of Rizhao from January 2014 to January 2016 were selected and retrospectively analyzed; they were divided into the bacterium (n=70) and virus (n=40) groups. Another 45 normal subjects were selected as the control group. Read More

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December 2018

Non-coding RNAs Function as Immune Regulators in Teleost Fish.

Front Immunol 2018 28;9:2801. Epub 2018 Nov 28.

Institute for Translational Medicine, Medical College of Qingdao University, Qingdao, China.

Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Read More

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November 2018

Digenic Inheritance of Shortened Repeat Units of the D4Z4 Region and a Loss-of-Function Variant in in a Family With FSHD.

Front Neurol 2018 28;9:1027. Epub 2018 Nov 28.

Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.

Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder which is typically transmitted by an autosomal dominant pattern, although reduced penetrance and sporadic cases caused by mutations, are often observed. FSHD may be caused by a contraction of a repetitive element, located on chromosome 4 (4q35). This locus is named and consists of 11 to more than 100 repeated units (RU). Read More

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November 2018

Understanding Therapeutic Concepts in Crohn's Disease.

Authors:
Gilles Rg Monif

Clin Med Insights Gastroenterol 2018 3;11:1179552218815169. Epub 2018 Dec 3.

Infectious Diseases Inc., Bellevue, NE, USA.

For more than a decade, the therapeutic focus for Crohn's disease has remained fixed at temporary arrestment of symptomology. The Centers for Disease Control and Prevention (CDC) lists Crohn's disease as a disease entity without current cure. Biologics in combination with antibiotics can frequently achieve remissions. Read More

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December 2018

Prevalence of mandibular fracture in patients visiting a tertiary dental care hospital in North India.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):123-128

Department of Oral Medicine and Radiology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Injuries of the maxillofacial complex represent one of the most important health problems worldwide. At present, in developing India, due to poor traffic sense, maxillofacial trauma and fractures are most epidemiologic diseases. Mandible is the largest and strongest facial bone and it is the second most commonly fractured bone. Read More

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December 2018

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Nature 2018 Dec 13. Epub 2018 Dec 13.

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.

We previously reported the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt-Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with prions. The marked deposition of parenchymal and vascular Aβ in these relatively young individuals with treatment-induced (iatrogenic) CJD (iCJD), in contrast to other prion-disease patients and population controls, allied with the ability of Alzheimer's disease brain homogenates to seed Aβ deposition in laboratory animals, led us to argue that the implicated c-hGH batches might have been contaminated with Aβ seeds as well as with prions. However, this was necessarily an association, and not an experimental, study in humans and causality could not be concluded. Read More

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December 2018
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REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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January 2019

Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7.

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.

Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secretion of adipokines. Circular RNAs (circRNAs), a novel type of noncoding RNA, have recently been recognized as key factors in tumor development, but the role of exosome circRNAs derived from adipose tissues has not been defined yet. Read More

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December 2018

Prevention and treatment of gout.

Nat Rev Rheumatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, University of Auckland, Auckland, New Zealand.

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December 2018

Late onset neonatal acute kidney injury: results from the AWAKEN Study.

Pediatr Res 2018 Dec 13. Epub 2018 Dec 13.

Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.

Background: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).

Methods: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Read More

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December 2018
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Epidemiological Characteristics of Atrial Fibrillation in Southern China: Results from the Guangzhou Heart Study.

Sci Rep 2018 Dec 13;8(1):17829. Epub 2018 Dec 13.

Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, 510080, China.

Precise prevalence of atrial fibrillation (AF) and the associated risk factors in southern China are rarely reported. This large population-based follow-up study, the Guangzhou Heart Study, was conducted from 2015 to 2017 to fill up this gap. Permanent residents aged 35 years and above in Guangzhou city were enrolled and demographic factors of participants were collected by a structured questionnaire. Read More

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December 2018

Control of T cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.

Nat Commun 2018 Dec 13;9(1):5298. Epub 2018 Dec 13.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.

To balance immunity and tolerance, the endogenous pool of Foxp3 regulatory T (T) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of T cells is negatively regulated by the kinase Lkb1 in dendritic cells (DCs). Conditional knockout of the Lkb1 gene in DCs leads to excessive T cell expansion in multiple organs and dampens antigen-specific T cell immunity. Read More

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December 2018
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Prevention of the anti-factor VIII memory B-cell response by inhibition of the Bruton's tyrosine kinase in experimental hemophilia A.

Haematologica 2018 Dec 13. Epub 2018 Dec 13.

INSERM UMR S 1138, Centre de Recherche des Cordeliers, Paris, France;

Hemophilia A is a rare hemorrhagic disorder due to the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the development of inhibitory anti-factor VIII IgG in up to 30% of the cases. To date, immune tolerance induction upon daily injection of large amounts of factor VIII is the only strategy to eradicate factor VIII inhibitors. Read More

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December 2018

Much to do with nothing: microsimulation study on time management in primary care.

BMJ 2018 Dec 13;363:k4983. Epub 2018 Dec 13.

VA Center for Clinical Management Research, Ann Arbor, Michigan, USA.

Objective: To investigate the credibility of claims that general practitioners lack time for shared decision making and preventive care.

Design: Monte Carlo microsimulation study.

Setting: Primary care, United States. Read More

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December 2018

An International Analysis of Dialysis Services Reimbursement.

Clin J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium; and.

Background And Objectives: The prevalence of patients with ESKD who receive extracorporeal kidney replacement therapy is rising worldwide. We compared government reimbursement for hemodialysis and peritoneal dialysis worldwide, assessed the effect on the government health care budget, and discussed strategies to reduce the cost of kidney replacement therapy.

Design, Setting, Participants, & Measurements: Cross-sectional global survey of nephrologists in 90 countries to assess reimbursement for dialysis, number of patients receiving hemodialysis and peritoneal dialysis, and measures to prevent development or progression of CKD, conducted online July to December of 2016. Read More

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December 2018
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Issues in Building a Nursing Home Syndromic Surveillance System with Textmining: Longitudinal Observational Study.

JMIR Public Health Surveill 2018 Dec 13;4(4):e69. Epub 2018 Dec 13.

Equipe de recherche (HANDIReSP), UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines et Université Paris-Saclay, Montigny-le-Bretonneux, France.

Background: New nursing homes (NH) data warehouses fed from residents' medical records allow monitoring the health of elderly population on a daily basis. Elsewhere, syndromic surveillance has already shown that professional data can be used for public health (PH) surveillance but not during a long-term follow-up of the same cohort.

Objective: This study aimed to build and assess a national ecological NH PH surveillance system (SS). Read More

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December 2018

Where No Universal Health Care Identifier Exists: Comparison and Determination of the Utility of Score-Based Persons Matching Algorithms Using Demographic Data.

JMIR Public Health Surveill 2018 Dec 13;4(4):e10436. Epub 2018 Dec 13.

Division of Global HIV and TB, Centers for Disease Control and Prevention, Nairobi, Kenya.

Background: A universal health care identifier (UHID) facilitates the development of longitudinal medical records in health care settings where follow up and tracking of persons across health care sectors are needed. HIV case-based surveillance (CBS) entails longitudinal follow up of HIV cases from diagnosis, linkage to care and treatment, and is recommended for second generation HIV surveillance. In the absence of a UHID, records matching, linking, and deduplication may be done using score-based persons matching algorithms. Read More

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December 2018

Carotid Endarterectomy with Autoarterial Remodeling of Bifurcation of the Common Carotid Artery and Carotid Endarterectomy with Patch Closure: Comparison of Methods.

J Stroke Cerebrovasc Dis 2018 Dec 11. Epub 2018 Dec 11.

Meshalkin National Medical Research Center, Ministry of Public Health of the Russian Federation, Novosibirsk, Russian Federation.

Background: The objectives of our research were to identify whether the new method of carotid endarterectomy (CEA) with autoarterial remodeling of bifurcation of the common carotid artery (ARBCCA) influences daily parameters of blood pressure and heart rate (HR) while monitoring them on a daily basis and to assess the efficacy of the suggested method.

Materials And Methods: It is a prospective randomized comparative study. The first group (n = 100) included patients that underwent ARBCCA, the second group (n = 100) included patients that underwent "classic" CEA with xenopericardial patch closure. Read More

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December 2018

Elective and emergent laparotomy closure: The importance of protocolizing the technique.

Cir Esp 2018 Dec 10. Epub 2018 Dec 10.

Cirugía de Pared Abdominal, Hospital Universitari Vall d'Hebron, Barcelona, España.

Background: Incisional hernias are a frequent complication, and their prevention includes proper closure of the abdominal wall.

Methods: A prospective study was conducted at a third-level hospital after the introduction of a midline laparotomy closure protocol. An objective measurement of the suture length to incision length ratio was made. Read More

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December 2018

[Editorial].

Authors:
J Salomon P Thomas

Encephale 2018 Dec 10. Epub 2018 Dec 10.

Pôle de psychiatrie médecine légale et médecine en milieu pénitentiaire, université de Lille, CHU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. Electronic address:

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December 2018

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.

Background: The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study.

Methods: IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Netherlands, France and Italy). Read More

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November 2018

Sex differences in the association of psychosocial resources with prevalent type 2 diabetes among African Americans: The Jackson Heart Study.

J Diabetes Complications 2018 Nov 22. Epub 2018 Nov 22.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Aim: To examine the association of psychosocial resources with prevalent type 2 diabetes (T2D) in 5104 African American men and women.

Methods: Using data from the Jackson Heart Study (JHS), we evaluated the cross-sectional associations of four psychosocial resources (social support, optimism, religiosity, and social networks) with T2D [fasting glucose ≥126 mg/dL, or HbA1c ≥ 6.5%, or use of diabetic medication]. Read More

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November 2018

Protective effect of Vaccinium myrtillus on ischemia- reperfusion injury in rat ovary.

Taiwan J Obstet Gynecol 2018 Dec;57(6):836-841

Erciyes University Institute of Health Sciences, Department of Hystology and Embryology, Kayseri, Turkey.

Objective: It is aimed to evaluate the protective effect of bilberry on I/R injury in rat ovary.

Materials And Methods: A total 48 female Wistar-Albino rats were utilized to form five groups: Group 1 (control group) (n = 8), neither drug was given and nor procedure was performed. Group 2 (bilberry control group) (n = 10), single dose 200 mg/kg bilberry was administered by gavage and no procedure was performed. Read More

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December 2018

How to "Get Out of Trouble" During Prostatic Artery Embolization.

Tech Vasc Interv Radiol 2018 Dec 29;21(4):288-294. Epub 2018 Jul 29.

Department of Radiology, University of North Carolina, Chapel Hill, NC; Interventional Radiologist, Vascular Institute of Virginia, Woodbridge, VA.

Prostatic artery embolization can be an extremely challenging procedure often giving the operator the sense of "being in trouble." This feeling can occur during different stages of the procedure including initial identification of the prostatic artery, catheterization of the prostatic artery, and prevention of non-target ischemia via extra-prostatic anastomoses during embolization. This brief guide provides techniques developed from prior experience with these frustrating situations that could potentially help the prostatic artery embolization operator "get out of trouble. Read More

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December 2018

Expanding vocabularies for complementary and alternative medicine therapies.

Int J Med Inform 2019 Jan 22;121:64-74. Epub 2018 Nov 22.

Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA.

Objective: There is a significant consumer demand for complementary and alternative medicine (CAM) therapies as possible alternatives to drugs in the treatment and prevention of chronic diseases. Expanding controlled vocabularies to include CAM treatment relations could help meet those needs by facilitating information retrieval from the published literature. The purpose of this study is to design and evaluate two methods to semi-automatically extract CAM treatment-related semantic predications (subject-predicate-object triplets) from the biomedical literature using the Semantic Medline database (SemMedDB). Read More

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January 2019

Interventions to Prevent CIED Infections: More or Less?

J Am Coll Cardiol 2018 Dec;72(24):3110-3111

Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota; Department of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Electronic address: https://twitter.com/riz1998.

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December 2018

Prevention of Arrhythmia Device Infection Trial: The PADIT Trial.

J Am Coll Cardiol 2018 Dec;72(24):3098-3109

Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Infection of implanted medical devices has catastrophic consequences. For cardiac rhythm devices, pre-procedural cefazolin is standard prophylaxis but does not protect against methicillin-resistant gram-positive organisms, which are common pathogens in device infections.

Objective: This study tested the clinical effectiveness of incremental perioperative antibiotics to reduce device infection. Read More

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December 2018

Music therapy intervention in cardiac autonomic modulation, anxiety, and depression in mothers of preterms: randomized controlled trial.

BMC Psychol 2018 Dec 13;6(1):57. Epub 2018 Dec 13.

School of Medicine, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: Mothers of preterm infants often have symptoms of anxiety and depression, recognized as risk factors for the development of cardiovascular diseases and associated with low rates of heart rate variability (HRV). This study aimed to evaluate the influence of music therapy intervention on the autonomic control of heart rate, anxiety, and depression in mothers.

Methods: Prospective randomized clinical trial including 21 mothers of preterms admitted to the Neonatal Intensive Care Unit of a tertiary hospital, recruited from August 2015 to September 2017, and divided into control group (CG; n = 11) and music therapy group (MTG; n = 10). Read More

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December 2018

Interventions for behaviour change and self-management in stroke secondary prevention: protocol for an overview of reviews.

Syst Rev 2018 Dec 13;7(1):231. Epub 2018 Dec 13.

School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.

Background: Stroke secondary prevention guidelines recommend medication prescription and adherence, active education and behavioural counselling regarding lifestyle risk factors. To impact on recurrent vascular events, positive behaviour/s must be adopted and sustained as a lifestyle choice, requiring theoretically informed behaviour change and self-management interventions. A growing number of systematic reviews have addressed complex interventions in stroke secondary prevention. Read More

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December 2018

Human papillomavirus vaccine delivery in Mozambique: identification of implementation performance drivers using the Consolidated Framework for Implementation Research (CFIR).

Implement Sci 2018 Dec 13;13(1):151. Epub 2018 Dec 13.

Department of Global Health, University of Washington, Harris Hydraulics Laboratory, 1510 San Juan Road, Seattle, WA, 98195, USA.

Background: Since 2012 Gavi, the Vaccine Alliance has provided financial support for HPV vaccine introduction in low- and middle-income countries (LMICs); however, funding has been contingent on establishing a demonstration project prior to national scale-up, in order to gauge effectiveness of delivery models. Although by 2016, most beneficiary countries had completed demonstration projects, few have scaled up delivery nationwide. An important barrier was the dearth of published, country-specific implementation recommendations. Read More

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December 2018

The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism.

J Exp Clin Cancer Res 2018 Dec 13;37(1):313. Epub 2018 Dec 13.

Chongqing Key Laboratory of Molecular Oncology and Epigenetics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Recent studies suggested the globin family member cytoglobin (CYGB) as a potential tumor suppressor; however, the mechanism by which CYGB suppresses cancer is elusive. We investigated the role and mechanism of CYGB in suppressing breast cancer.

Methods: CYGB expression was examined by reverse transcription PCR, quantitative reverse transcription PCR and open database analysis. Read More

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December 2018
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