2,288 results match your criteria Prescriber [Journal]


Uptake of direct acting antiviral therapies for the treatment of hepatitis C virus among people who inject drugs in a universal health-care system.

Drug Alcohol Rev 2018 Dec 12. Epub 2018 Dec 12.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Introduction And Aims: Direct acting antiviral (DAA) treatment can reduce hepatitis C virus (HCV) infection incidence and mortality, although large scale uptake of these treatments is necessary to achieve those reductions. Targeting people who inject drugs (PWID) will be crucial to achieve the necessary reductions. Previously, treatment uptake has been very low (1-2%) among PWID, but these new DAAs have been subsidised in Australia since March 2016. Read More

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December 2018

Deprescribing conversations: a closer look at prescriber-patient communication.

Ther Adv Drug Saf 2018 Dec 20;9(12):687-698. Epub 2018 Oct 20.

Facultés de Médecine et de Pharmacie, Université de MontréalResearch Center of Institut Universitaire de Gériatrie de Montréal, Québec, Canada.

Background: Little is known about the initiation, style and content of patient and healthcare provider communication around deprescribing. We report the findings from a content analysis of audio-recorded discussions of proton pump inhibitor (PPI) and benzodiazepine deprescribing in primary care.

Methods: Participants were healthcare providers ( = 13) from primary care practices ( = 3) and patients aged ⩾65 ( = 24) who were chronic users of PPIs or benzodiazepines. Read More

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December 2018

First-generation second-generation long-acting injectable antipsychotic drugs and time to relapse.

Ther Adv Psychopharmacol 2018 Dec 25;8(12):333-336. Epub 2018 Sep 25.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Background: The development of long-acting injectable formulations (LAIs) of second-generation antipsychotic drugs (SGAs) has been suggested as having advantage over first-generation antipsychotic (FGA) LAIs. In this study, we investigated the hypothesis that there was a longer time to relapse in patients with schizophrenia started on SGA LAI FGA LAI.

Methods: Patients with a diagnosis of schizophrenia or schizoaffective disorder who were started on an SGA LAI while on an inpatient ward were identified through searching of the anonymised historical medical records at the South London and Maudsley NHS Foundation Trust. Read More

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December 2018

Pharmacists' Perspectives on Practice, Availability, and Barriers Related to Opioids in Georgia.

Am J Hosp Palliat Care 2018 Dec 6:1049909118815440. Epub 2018 Dec 6.

3 Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.

Objectives:: To explore pharmacists' perspectives on practice, availability, and barriers related to opioids.

Methods:: This cross-sectional study evaluated pharmacists' perspectives on practice, availability, and barriers related to opioids. Electronic surveys were distributed to pharmacists practicing in Georgia via Survey Monkey. Read More

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December 2018

Prescribing trends and revisit rates following a pharmacist-driven protocol change for community-acquired pneumonia in an emergency department.

Int J Pharm Pract 2018 Dec 11. Epub 2018 Dec 11.

University of Pittsburgh Medical Center - Mercy Hospital, Pittsburgh, PA, USA.

Objective: To compare pharmacist-led prescribing changes and associated 30-day revisit rates across different regimens for patients discharged from an emergency department (ED) with a diagnosis of community-acquired pneumonia (CAP).

Methods: An observational, retrospective cohort analysis was conducted of patients who were discharged from an ED over a 4-year period with a diagnosis of CAP. Patient demographics, clinical characteristics, antibiotic selection and comorbidity and condition severity scores were collected for two cohorts: 2012-13 (before protocol change) and 2014-15 (post-protocol change). Read More

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December 2018

Modifying emergency department electronic prescribing for outpatient opioid analgesia.

Emerg Med Australas 2018 Dec 3. Epub 2018 Dec 3.

Emergency Medicine, Austin Health, Melbourne, Victoria, Australia.

Objectives: The aim of this study was to examine how changing the electronic ordering sequences for opioid analgesics affected ED outpatient prescribing, and subsequent unused opioid tablets remaining in the community available for diversion.

Methods: A descriptive before and after study in adult patients prescribed an opioid analgesic by an ED prescriber for use in the outpatient setting. The hospital electronic prescribing system (FirstNet™) was modified to include smaller quantities of opioid analgesics for discharge. Read More

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December 2018
2 Reads

The clinical impact of a urinary tract infection management bundle in a tertiary-care teaching hospital.

Infect Control Hosp Epidemiol 2018 Dec 3:1-7. Epub 2018 Dec 3.

6Department of Internal Medicine,Horizon Health Network,Moncton, New Brunswick,Canada.

Objective: The aim of this study was to assess the impact of a urinary tract infection (UTI) management bundle to reduce the treatment of asymptomatic bacteriuria (AB) and to improve the management of symptomatic UTIs.

Design: Before-and-after intervention study.SettingsTertiary-care hospital. Read More

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December 2018

Impact of a Prescriber-driven Antibiotic Time-out on Antibiotic Use in Hospitalized Patients.

Clin Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.

A multicenter quasi-experimental study of a provider-driven antibiotic "time-out" in 3470 antibiotic courses showed no difference in antibiotic use before and after implementation, but did show a decrease in inappropriate therapy (45% vs 31%, P < .05). Single time-outs without input from antibiotic stewardship teams are insufficient to optimize prescribing. Read More

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December 2018
4 Reads

Off-Label Medication in Children: Responsibilities of Pediatrician and Neonatologist.

Mymensingh Med J 2018 Oct;27(4):912-916

Professor Jagadish C Das, Professor, Department of Neonatology, Chittagong Medical College, Chittagong, Bangladesh; E-mail:

Use of drug in pediatrics and neonatology should be rational. There are clinical situations when the use of unlicensed medicines or use of medicines outside the terms of license (i.e. Read More

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October 2018
1 Read

Outreach training and supportive supervision for malaria case management in Zambia: the effects of focused capacity building on indicators of diagnostic and clinical performance.

Malar J 2018 Nov 28;17(1):438. Epub 2018 Nov 28.

Medical Care Development International, Silver Spring, MD, USA.

Background: Accurate diagnosis of malaria and reduced reliance on presumptive treatment are crucial components of quality case management. From 2008 to 2012, the Improving Malaria Diagnostics project, in collaboration with the Zambia National Malaria Control Centre, implemented an external quality assurance scheme partially comprised of outreach training and supportive supervision (OTSS) in an effort to improve malaria case management across a spectrum of health facilities performing laboratory-based malaria diagnostics. OTSS assessments were conducted by project-trained laboratory and clinical supervisors on a regular basis and measured changes in health facility staff performance over time. Read More

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November 2018

State Approaches to Therapeutic Interchange in Community Pharmacy Settings: Legislative and Regulatory Authority.

J Manag Care Spec Pharm 2018 Dec;24(12):1260-1263

3 MPH, Idaho State Board of Pharmacy, Boise.

Therapeutic interchange is the act of switching a prescribed drug for another drug in the same therapeutic class that is believed to be therapeutically similar but may be chemically different. Therapeutic interchange is different from generic substitution in that it does not occur between therapeutically equivalent products; instead, products are substituted for those that are likely to have a substantially equivalent therapeutic effect generally at a lower cost. Therapeutic interchange is common in institutional settings across the United States but rarely occurs in community pharmacy settings without a pharmacist first contacting the original prescriber and requesting a new prescription in order to facilitate a change. Read More

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December 2018
1 Read

Clinical Utility of Pharmacogenetic Testing and a Clinical Decision Support Tool to Enhance the Identification of Drug Therapy Problems Through Medication Therapy Management in Polypharmacy Patients.

J Manag Care Spec Pharm 2018 Dec;24(12):1250-1259

5 Pharmacotherapy Outcomes Research Center and Department of Pharmacotherapy, University of Utah, Salt Lake City, and Program in Personalized Health Care, University Health, Salt Lake City, Utah.

Background: In polypharmacy patients, medication therapy management (MTM) services provide a comprehensive review of current medications and future treatment goals. Pharmacogenetics (PGx) may further optimize the identification of potential drug therapy problems (DTPs); however, the clinical utility of PGx information with a clinical decision support tool (CDST) in an MTM setting in identifying DTPs has not been systematically assessed.

Objective: To assess the clinical utility of an MTM service enhanced by pharmacogenetic test results and a clinical decision support tool. Read More

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December 2018

Electronic decision support for treatment of hospitalized smokers: A qualitative analysis of physicians' knowledge, attitudes, and practices.

Drug Alcohol Depend 2018 Oct 26;194:296-301. Epub 2018 Oct 26.

Yale School of Medicine, Department of Emergency Medicine, New Haven, CT, 06519, USA; Yale University School of Public Health, Department of Health Policy and Management, New Haven, CT, 06520, USA.

Background: We recently demonstrated the ability of a suite of tools embedded in an electronic medical record (EMR) to improve tobacco cessation treatment for adult smokers admitted to the hospital. A randomized controlled trial conducted by our group demonstrated the ability of an EMR-embedded tobacco use disorder treatment tool, the Electronic Support Tool and Orders for the Prevention of Smoking (E-STOPS), to increase the identification and treatment of smokers, but its uptake varied among 126 physicians randomized to the intervention arm. The purpose of this study was to identify facilitators and barriers to using E-STOPS. Read More

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October 2018
4 Reads

Antimicrobial use practices, attitudes and responsibilities in UK farm animal veterinary surgeons.

Prev Vet Med 2018 Dec 30;161:115-126. Epub 2018 Oct 30.

Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK.

Increasing levels of antimicrobial resistance in human and veterinary medicine have raised concerns around the issue of overprescribing and the indiscriminate use of antimicrobials. Their use in food producing animals is under scrutiny due to the perceived risk from the zoonotic transfer of resistant pathogens from animals to humans. This study aimed to explore UK veterinary surgeons antimicrobial prescribing behaviours, their attitudes to antimicrobial resistance and their perceptions of responsibility of antimicrobial use in pigs through a questionnaire study on a census sample of 261 veterinary surgeons in England, Wales and Scotland who had a clinical caseload which included commercial pigs. Read More

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December 2018
2 Reads

Systematic review of computerized prescriber order entry and clinical decision support.

Am J Health Syst Pharm 2018 Dec;75(23):1909-1921

Pharmacy Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Purpose: Results of a systematic review of published data on the effect of computerized prescriber order entry (CPOE) with clinical decision support on medication error (ME) and adverse drug event (ADE) rates are presented.

Methods: Literature searches of MEDLINE, Embase, and other databases were conducted to identify English- and Spanish-language articles on selected CPOE outcomes published from 1995 through 2016; in addition, 5 specific journals were searched for pertinent articles published during the period 2010-16. Publications on controlled prospective studies and before-and-after studies that assessed MEs and/or ADEs as main outcomes were selected for inclusion in the review. Read More

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December 2018
4 Reads

Opioids and cancer pain.

Authors:
Jo Thompson

Int J Palliat Nurs 2018 Nov;24(11):536-538

Lead Nurse, Supportive and Palliative Care and Nurse Prescriber, Royal Surrey County Hospital NHS Foundation Trust.

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November 2018

[Evaluation of surgical antibiotic prophylaxis in a Tunisian University Hospital].

Pan Afr Med J 2018 2;30:191. Epub 2018 Jul 2.

Direction Régionale de la Santé, Kairouan, Tunisie.

Antibiotic prophylaxis (ATBP) is one of the specific measures for the prevention of surgical site infections, whose impact has been quantified in clean or clean-contaminated surgery. Our study aims to evaluate the conformity of ATBP practices and the adherence to the prescribing protocols adopted in our Hospital. We conducted a clinical audit retrospective observational study, evaluating antibiotic prophylaxis practices in our Hospital in the month of March 2015. Read More

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December 2018
5 Reads

Medication prescribing errors: a pre- and post-computerized physician order entry retrospective study.

Int J Clin Pharm 2018 Nov 16. Epub 2018 Nov 16.

Clinical Pharmacy Department, Toulouse University Hospital Centre, 1 Avenue du Professeur Jean Poulhès, 31059, Toulouse, France.

Background The computerization of prescriptions with a computerized physician order entry contributes to securing the error-free drug supply, but is not risk-free. Objective: To determine the impact of a computerized physician order entry system on prescribing errors immediately after its implementation and 1 year later. Setting The Cardiology and Diabetology Departments at Toulouse University Hospital, France. Read More

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November 2018
2 Reads

Opioid Prescribing Patterns Among American Society of Ophthalmic Plastic and Reconstructive Surgery Members in the Medicare Part D Database.

Ophthalmic Plast Reconstr Surg 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, Irvine, California.

Purpose: To assess opioid prescribing patterns among American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) members.

Methods: An observational, retrospective, cohort study of ASOPRS members' prescribing patterns in the 2013-2016 Medicare Part D Prescriber database. These prescribers were stratified by years in practice, sex, and geography. Read More

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November 2018

Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 2: Strategies to Minimize Adverse Outcomes From Unintended DDIs.

J Psychiatr Pract 2018 Sep;24(5):341-347

PRESKORN: Kansas University School of Medicine-Wichita, Wichita, KS.

This column is the second in a series exploring drug-drug interactions (DDIs) with a special emphasis on psychiatric medications. The first column in this series discussed why patients being treated with psychiatric medications are at increased risk for taking multiple medications and thus experiencing DDIs and how to recognize such DDIs, and strategies for avoiding them. This second column in the series discusses strategies for minimizing adverse outcomes from such unintended DDIs. Read More

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September 2018
1 Read

[Utilisation of first-line antibiotics six years after a multifaceted intervention].

Rev Esp Quimioter 2018 Dec 5;31(6):520-527. Epub 2018 Nov 5.

José María Molero, Centro de Salud San Andrés, Madrid C/ Alberto Palacios, 22, 28021 Madrid. Spain.

Objective: No study has evaluated the impact of a multifaceted intervention on the quality of the antibiotics prescribed more than 5 years later.

Methods: A total of 210 general practitioners (GP) from eight different regions of Spain were asked to participate in two registrations of respiratory tract infections (RTI) in 2008, before, and in 2009, just after a multifaceted intervention including prescriber feedback, clinical guidelines, training sessions focused on appropriate antibiotic prescribing, workshop on rapid tests and provision of these tests in the GP consultation. They were all again invited to participate in a similar registration in 2015. Read More

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December 2018

Factors influencing the use of the "not for generic substitution" mention for prescriptions in primary care: a survey with general practitioners.

BMC Health Serv Res 2018 Nov 12;18(1):850. Epub 2018 Nov 12.

Medical Information Department, Centre Hospitalier de Troyes, 10000, Troyes, France.

Background: Generic drug substitution is a public health policy challenge with high economic potential. Generic drugs are generally cheaper than brand-name drugs. Drugs are a significant part of the total health expenditure, especially in ambulatory care. Read More

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November 2018
7 Reads

Direct-to-consumer advertising effects on nurse-patient relationship, authority, and prescribing appropriateness.

Authors:
Anna A Filipova

Nurs Ethics 2018 Nov 16;25(7):823-840. Epub 2016 Dec 16.

University of Wisconsin-Oshkosh, USA.

Background:: Discussing direct-to-consumer advertising of prescription drugs during a visit could affect prescribing practices and provider-patient relationship.

Research Objectives:: The study examines advanced practice nurse prescribers' perceptions of direct-to-consumer advertising and its effects on nurse-patient relationship, prescriptive authority, and appropriateness of patient clinical requests.

Research Design:: A cross-sectional survey design was implemented. Read More

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November 2018

Dog owner flea/tick medication purchases in the USA.

Parasit Vectors 2018 Nov 6;11(1):581. Epub 2018 Nov 6.

Merck Animal Health, 2 Giralda Farms, Madison, NJ, 07940, USA.

Background: Veterinary clinic transaction records from the USA were examined to determine dog owner purchase patterns for three prescription ectoparasiticides. In-clinic purchases of formulations of fluralaner (with 12-week duration per dose) were compared with dog owner purchases of afoxolaner and spinosad (both with 4 week duration per dose) in a population of 231,565 dogs over a 12 month period. Prior studies in human and animal medicine have suggested that patients more closely adhere to prescriber dosing recommendations when they receive a longer-duration medication. Read More

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November 2018

Routine opioid outcome monitoring in community pharmacy: Pilot implementation study protocol.

Res Social Adm Pharm 2018 Oct 22. Epub 2018 Oct 22.

National Drug and Alcohol Centre, University of New South Wales, Sydney, Australia; Drug Policy Modelling Program, University of New South Wales, Sydney, Australia.

Background: Increases in opioid use and related harms such as mortality are occurring in many high income countries. Community pharmacists are often in contact with patients at risk of opioid-related harm and represent an ideal point for intervention. Best practice in monitoring opioid-related outcomes involves assessing analgesia, pain functioning, mood, risks and harms associated with opioid use. Read More

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October 2018
5 Reads

Scleral lens fitting and assessment strategies.

Cont Lens Anterior Eye 2018 Oct 31. Epub 2018 Oct 31.

The Ohio State University, Columbus, Ohio, United States.

Purpose: To describe prescriber reported scleral lens fitting and assessment strategies.

Methods: The SCOPE (Scleral Lenses in Current Ophthalmic Practice Evaluation) study group designed and administered an IRB approved, electronic survey (REDCap) regarding current scleral lens fitting and assessment methods. The survey was distributed to attendees of the 2017 Global Specialty Lens Symposium. Read More

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October 2018
4 Reads

Egyptian community pharmacists' attitudes and practices towards antibiotic dispensing and antibiotic resistance; a cross- sectional survey in Greater Cairo.

Curr Med Res Opin 2018 Nov 2:1-18. Epub 2018 Nov 2.

b Department of Pharmacy Practice, Faculty of Pharmacy , Helwan University , Cairo , Egypt.

Background: Antibiotic resistance is an increasing worldwide crisis. In Egypt, it is prohibited by law to dispense antibiotics with no prescription; however, there are no active and enforced governmental policies and lows to regulate such process. This led to increased antibiotic dispensing and consumption. Read More

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November 2018
3 Reads

[Good practices in prescribing benzodiazepines].

Presse Med 2018 Oct 29;47(10):872-877. Epub 2018 Oct 29.

Centre hospitalier universitaire, faculté de médecine, service de pharmacologie médicale et clinique, 31000 Toulouse, France. Electronic address:

Due to pharmacologic tolerance and dependence, benzodiazepines and z-drugs have to be used over short duration of treatment. Three pharmacokinetic characteristics should be taken into account by the prescriber: the galenic form, the plasma half-life, and the presence of an active metabolite. The patient and the prescriber should talk about possible adverse events and treatment discontinuation before treatment initiation. Read More

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October 2018

Association Between Market Competition and Prices of Generic Topical Dermatology Drugs.

JAMA Dermatol 2018 Dec;154(12):1441-1446

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: During the last decade, increases in drug prices for commonly prescribed dermatologic medications have outpaced the rate of inflation, national health care growth, and reimbursements. Among nondermatologic medications, studies have shown a role for robust generic market competition in reducing drug prices. The association between competition and the costs of topical dermatologic generic drugs has not been evaluated. Read More

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December 2018
1 Read

Medication Error- A Case Report of Misadventure with Methotrexate.

JNMA J Nepal Med Assoc 2018 Mar-Apr;56(211):711-715

Department of Otorhinolaryngology and Head & Neck Surgery, Medanta- The Medicity, Gurugram, Haryana, India.

Methotrexate is an antimetabolite drug with antineoplastic and immunomodulatory properties, useful as an antineoplastic agent in various haematological and solid tumours. MTX toxicity can occur because of accidental ingestion/overdose by the patient or because of prescription error. The toxic effects manifest as severe mucositis or as organ damage (bone marrow depression, renal/hepatic injury). Read More

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November 2018
5 Reads

Assessment of prior opioid tolerance among new users of fentanyl transdermal system in FDA's Sentinel System.

Pharmacoepidemiol Drug Saf 2018 Oct 31. Epub 2018 Oct 31.

Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Purpose: Fentanyl transdermal system (FTS) is intended only for patients with prior opioid tolerance. The purpose of this study is to identify the proportion of new FTS users who had evidence of prior opioid tolerance, by dosage strength, in FDA's Sentinel System.

Methods: We identified new FTS episodes (183-day washout) from 2009 through 2013. Read More

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October 2018
10 Reads

Who diagnosed and prescribed what? Using provider details to inform observational research.

Pharmacoepidemiol Drug Saf 2018 Dec 31;27(12):1422-1426. Epub 2018 Oct 31.

Department of Health Sciences, Northeastern University, Boston, Massachusetts, USA.

Purpose: To describe how often patients with depression initiating antidepressants receive their depression diagnosis and prescriptions from the same provider and, when simultaneously initiating benzodiazepines, how often both prescriptions come from the same provider.

Methods: Using a US healthcare claims database, we created a cohort of adults (18-64 years) with a depression diagnosis who initiated antidepressants. We examined concordance by provider specialty and provider identifier between (a) the first antidepressant prescription fill and most proximal depression diagnosis, and (b) the initial antidepressant and benzodiazepine prescription fills among simultaneous benzodiazepine and antidepressant initiators. Read More

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December 2018

Impact of Empowering Leadership on Antimicrobial Stewardship: A Single Center Study in a Neonatal and Pediatric Intensive Care Unit and a Literature Review.

Front Pediatr 2018 12;6:294. Epub 2018 Oct 12.

Department of Pediatrics, Children's Hospital Lucerne, Lucerne, Switzerland.

Antimicrobial stewardship (AMS) is an important strategy of quality improvement for every hospital. Leadership is an important factor for implementation of quality improvement and AMS programs. Recent publications show successful AMS programs in children's hospitals, but successful implementation is often difficult to achieve and literature of AMS in neonatal and pediatric intensive care units (NICU/PICU) is scarce. Read More

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October 2018
5 Reads

Continuation of postmenopausal hormone replacement therapy: comparison of cyclic versus continuous combined schedules.

Menopause 2018 Nov;25(11):1187-1190

Wyeth Ayerst Laboratories, Philadelphia, Pennsylvania, U.S.A.

Discontinuation of hormone replacement therapy (HRT) is much more common than what is reported in randomized, double-blind clinical trials. Our purpose in this retrospective study, using a prescription database, was to compare the continuation rate among women who took cyclic combination therapy adding progesterone to estrogen (CYC-PERT) or continuous combined estrogen progestin therapy (CC-PERT). The study subjects were 1,532 women, ≥45 years old, who initially filled index prescriptions for 0. Read More

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November 2018
6 Reads

Real-world effectiveness of long-acting antipsychotic treatments in a nationwide cohort of 3957 patients with schizophrenia, schizoaffective disorder and other diagnoses in Quebec.

Ther Adv Psychopharmacol 2018 Nov 22;8(11):287-301. Epub 2018 Jun 22.

CR-CHUM, University of Montréal, Montréal, Québec, Canada Faculty of Pharmacy, University of Montréal, Montréal, Québec, Canada.

Background: Long-acting injectable antipsychotics (LAI-AP) for patients with schizophrenia (SCZ) have saved significant healthcare costs. However, the cost effectiveness of LAI-AP for patients with other mental disorders has yet to be established. The goal of this study was to evaluate the impact of early initiation of LAI-AP medications on healthcare resource utilization (HRU). Read More

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November 2018
3 Reads

Telementoring for hepatitis C treatment in correctional facilities.

J Telemed Telecare 2018 Dec;24(10):690-696

3 Department of Gastroenterology and Hepatology; PA-Southside Clinical School, The University of Queensland; Translational Research Institute, Princess Alexandra Hospital, Australia.

Introduction Prevalence of hepatitis C virus (HCV) is substantially higher among prisoners than the general population. In Australia until recently, only a small proportion of prisoners with HCV received antiviral therapy. The direct-acting antivirals (DAAs) for HCV are highly effective, with a low burden of side effects. Read More

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December 2018
3 Reads

Varenicline and Bupropion for Long-Term Smoking Cessation (the MATCH Study): Protocol for a Real-World, Pragmatic, Randomized Controlled Trial.

JMIR Res Protoc 2018 Oct 18;7(10):e10826. Epub 2018 Oct 18.

Nicotine Dependence Service, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Background: Varenicline and bupropion are efficacious, prescription-only pharmacotherapies for smoking cessation; however, their real-world impact is limited by prescriber knowledge, affordability, and accessibility.

Objective: The primary objective of the MATCH (Medication Aids for Tobacco Cessation Health) study was to evaluate the real-world, long-term effectiveness of mailed bupropion and varenicline in a sample of interested smokers with the utilization of Web-based recruitment and follow-up. In addition, the study aims to investigate the genotypic and phenotypic predictors of cessation. Read More

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October 2018
1 Read

A multi-level strategy for a long lasting reduction in unnecessary laboratory testing: A multicenter before and after study in a teaching hospital network.

Int J Clin Pract 2018 Oct 19:e13286. Epub 2018 Oct 19.

Department of Internal Medicine, San Giovanni Hospital, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Background: Reducing unnecessary laboratory blood testing in the hospital setting represents a challenge to improve the adequacy of healthcare and a tricky task for teaching hospitals. Our hospital network actively participates in the Choosing Wisely Campaign and is engaged in avoiding unnecessary low value interventions and investigations. We aimed to study whether a multi-level approach combining educational and web-system based interventions, could be effective in reducing laboratory testing and related costs. Read More

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October 2018

Prevalence and incidence of prescription opioid analgesic use in Australia.

Br J Clin Pharmacol 2018 Oct 19. Epub 2018 Oct 19.

National Drug and Alcohol Research Centre, UNSW Sydney, Sydney, NSW, Australia.

Aims: The aims of the current study were to determine the prevalence and incidence of prescription opioid analgesic use in Australia and compare the characteristics of people with and without cancer initiating prescription opioid analgesics.

Methods: A retrospective population-based study was conducted using the random 10% sample of adults who were dispensed prescription opioid analgesics in Australia between July 2013 and June 2017 through the Pharmaceutical Benefits Scheme. Poisson regression was used to calculate rate ratios (RR) for opioid prevalence and incidence. Read More

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October 2018
4 Reads

Does knowledge of patient non-compliance change prescribing behavior in the real world? A claims-based analysis of patients with serious mental illness.

Clinicoecon Outcomes Res 2018 2;10:573-585. Epub 2018 Oct 2.

Health Economics and Outcomes Management, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA.

Background: New digital technologies offer providers the promise of more accurately tracking patients' medication adherence. It is unclear, however, whether access to such information will affect provider treatment decisions in the real world.

Methods: Using prescriber-reported information on patient non-compliance from health insurance claims data between 2008 and 2014, we examined whether prescribers' knowledge of non-compliance was associated with different prescribing patterns for patients with serious mental illness (SMI). Read More

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October 2018
10 Reads

Dimethyl fumarate and teriflunomide for multiple sclerosis in a real-life setting: a French retrospective cohort study.

Eur J Neurol 2018 Oct 15. Epub 2018 Oct 15.

Service de Neurologie, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.

Background And Purpose: Dimethyl fumarate (DMF) and teriflunomide are approved oral disease-modifying treatments for relapsing-remitting multiple sclerosis (MS). Phase 3 trials established these agents to be effective and generally well tolerated, although comparative efficacy and discontinuation rates are still unknown. The aim of this study was to assess real-world efficacy and discontinuation of DMF and teriflunomide in patients with relapsing-remitting MS. Read More

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October 2018

Promoting oral potassium administration in a tertiary care hospital: An eleven-year study.

Ann Pharm Fr 2018 Oct 6. Epub 2018 Oct 6.

Service pharmaceutique, hospices Civils de Lyon, hôpital de la Croix-Rousse, groupement hospitalier Nord, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address:

Introduction: Potassium is used to treat or prevent hypokalemia and exhibits all the characteristics of an intravenous to oral therapy conversion program. Despite this, the intravenous route for potassium replacement seems frequently unjustified.

Objectives: To determine the impact of a conversion program on the use of intravenous and oral galenic forms in a university tertiary care hospital. Read More

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October 2018
2 Reads

Cost-effectiveness analysis of doctor-pharmacist collaborative prescribing for venous thromboembolism in high risk surgical patients.

BMC Health Serv Res 2018 Oct 1;18(1):749. Epub 2018 Oct 1.

Australian Centre for Health Services Innovation, School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, 4059, Australia.

Background: Current evidence to support cost effectiveness of doctor- pharmacist collaborative prescribing is limited. Our aim was to evaluate inpatient prescribing of venous thromboembolism (VTE) prophylaxis by a pharmacist in an elective surgery pre-admission clinic against usual care, to measure any benefits in cost to the healthcare system and quality adjusted life years (QALYs) of patients.

Method: A decision tree model was developed to assess cost effectiveness of pharmacist prescribing compared with usual care for VTE prophylaxis in high risk surgical patients. Read More

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October 2018
1 Read

Real-world incidence of patient-reported dyspnoea with ticagrelor.

Ther Adv Drug Saf 2018 Oct 9;9(10):577-584. Epub 2018 Aug 9.

SA Pharmacy, Flinders Medical Centre, Bedford Park, Australia.

Dyspnoea, a common and multifactorial symptom in patients with acute coronary syndrome, has been associated with lower quality of life and hospital readmission. Prescriber preference for antiplatelet therapy, the standard of care in this patient group, is shifting to ticagrelor due to mortality benefits demonstrated in trials compared with clopidogrel. In these trials, dyspnoea was more commonly reported in patients prescribed ticagrelor but the aetiology is still debated. Read More

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October 2018
10 Reads

Concentrated insulins: History and critical reappraisal.

J Diabetes 2018 Sep 28. Epub 2018 Sep 28.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.

The earliest marketed insulins were crude acidic formulations with concentrations of ≤10 units/mL. Since the early 1920s, insulins have improved continually, via bioengineering, process, and chemical modifications. Today, most insulin formulations have a concentration of 100 units/mL (U100). Read More

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September 2018
7 Reads

Predictors of Cholinesterase Discontinuation during the First Year after Nursing Home Admission.

J Am Med Dir Assoc 2018 Nov 24;19(11):959-966.e4. Epub 2018 Sep 24.

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada. Electronic address:

Objectives: For persons with dementia, the appropriate duration of cholinesterase inhibitor (ChEI) use remains unclear. We examined patterns of ChEI use during nursing home (NH) transition and the factors associated with discontinuation following admission.

Design: Population-based retrospective cohort study using linked health administrative and Resident Assessment Instrument Minimum Dataset, version 2. Read More

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November 2018
14 Reads

Development and validation of key performance indicators for medication management services provided for outpatients.

Res Social Adm Pharm 2018 Sep 22. Epub 2018 Sep 22.

Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Background: One of the elements of quality improvement of medication management services is measuring the quality of care and key performance indicators (KPIs) can be used in this assessment. There has been no publishing yet about a KPI instrument developed for ambulatory setting.

Objectives: To develop and validate KPI instrument for medication management services provided for outpatients in Brazilian context. Read More

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September 2018
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Prescribing trends for biologic drugs among Ohio dermatologists.

Dermatol Online J 2018 Jul 15;24(7). Epub 2018 Jul 15.

University Hospitals Cleveland Medical Center, Department of Dermatology, Cleveland, Ohio.

The role of biologic therapies in the field of dermatology continues to evolve as newer drugs and biosimilars are introduced to the U.S. market. Read More

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July 2018
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