12,638 results match your criteria Prepubertal Testicular and Paratesticular Tumors


Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

J Endocr Soc 2018 Dec 15;2(12):1345-1356. Epub 2018 Oct 15.

University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Context: Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life.

Objective: To evaluate the effects of r-hFSH, human chorionic gonadotropin (hCG), and testosterone (T) in such patients.

Design And Setting: Retrospective review in three tertiary centers in Finland between 2006 and 2016. Read More

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December 2018

Potential Anatomic Markers of Obstructive Sleep Apnea in Prepubertal Children.

J Clin Sleep Med 2018 Nov 29. Epub 2018 Nov 29.

Study Objectives: Adenotonsillar hypertrophy is the major cause of obstructive sleep apnea (OSA) in prepubertal children, but children without enlarged lymphoid tissues may still suffer from OSA. This study aimed to identify other potential anatomic features associated with childhood OSA.

Methods: This prospective study took place between January 2010 and April 2014. Read More

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November 2018
2 Reads

Endocrine aspects of Klinefelter syndrome.

Curr Opin Endocrinol Diabetes Obes 2018 Nov 30. Epub 2018 Nov 30.

Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Klinefelter syndrome is the most common sex chromosome abnormality in men. Hypogonadism and testicular degeneration are almost universal. Truncal adiposity, metabolic syndrome and low bone mass occur frequently. Read More

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November 2018

Leukemia and male infertility: past, present, and future.

Leuk Lymphoma 2018 Dec 3:1-10. Epub 2018 Dec 3.

a The Shraga Segal Dept. of Microbiology, Immunology, and Genetics , Ben-Gurion University of the Negev , Beer-Sheva , Israel.

Spermatogenesis is the process of the proliferation and differentiation of spermatogonial stem cells (SSCs) to generate sperm. Leukemia patients show impairment in some of the endocrine hormones that are involved in spermatogenesis. They also show a decrease in semen parameters before and after thawing of cryopreserved samples compared to a control. Read More

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December 2018

Development of Spermatogenesis In Vitro in Three-Dimensional Culture from Spermatogonial Cells of Busulfan-Treated Immature Mice.

Int J Mol Sci 2018 Nov 29;19(12). Epub 2018 Nov 29.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Beer-Sheva 84105, Israel.

Aggressive chemotherapy may lead to permanent male infertility. Prepubertal males do not generate sperm, but their testes do contain spermatogonial cells (SPGCs) that could be used for fertility preservation. In the present study, we examined the effect of busulfan (BU) on the SPGCs of immature mice, and the possible induction of the survivor SPGCs to develop spermatogenesis in 3D in-vitro culture. Read More

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November 2018

Depressive Symptoms, Perceived Stress, and Cortisol in School-Age Children With Type 1 Diabetes: A Pilot Study.

Biol Res Nurs 2018 Dec 5:1099800418813713. Epub 2018 Dec 5.

4 School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.

Despite adequate insulin regimens and concurrent treatments for Type 1 diabetes (T1D), many children have trouble achieving glycemic control, as evidenced by elevated HbA1c levels. Maternal and child depressive symptoms, as well as child perceived stress, are associated with less optimal glycemic control. Cortisol, a stress hormone, may mediate the relationships among depressive symptoms, perceived stress, and glycemic control. Read More

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December 2018
2 Reads

Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome.

Korean J Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.

Purpose: In the present study, the growth response following growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations was analyzed.

Methods: Twenty three patients with prepubertal NS were enrolled in the study at Pusan National University Children's Hospital, between March 2009 and July 2017. According to disease-causing genes identified, patients with NS were divided into four groups. Read More

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December 2018

Treatment with the synthetic PPARG ligand pioglitazone ameliorates early ovarian alterations induced by dehydroepiandrosterone in prepubertal rats.

Pharmacol Rep 2018 Sep 22;71(1):96-104. Epub 2018 Sep 22.

Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina. Electronic address:

Background: Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear factor that may act on the early development of ovarian follicles and on follicular steroidogenesis. However, the exact mechanism of PPARG action remains unknown. We have previously found that androgen excess alters early ovarian function and the PPARG system. Read More

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September 2018

Perfluorododecanoic acid blocks rat Leydig cell development during prepuberty.

Chem Res Toxicol 2018 Nov 29. Epub 2018 Nov 29.

Perfluorododecanoic acid (PFDoA) has been used as a surfactant and may have reproductive toxicity. However, whether PFDoA influences Leydig cell development during prepuberty remains unknown. In the present study, 21-day-old male Sprague Dawley rats were gavaged 0, 5 or 10 mg/kg PFDoA from postnatal day 21 to 35. Read More

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November 2018
2 Reads

Labial adhesions in postmenopausal women: presentation and management.

Int Urogynecol J 2018 Nov 28. Epub 2018 Nov 28.

Department of Urogynaecology, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore, 229899, Singapore.

Labial adhesion is defined as complete or partial fusion of the labia minora in the midline through flimsy or dense adhesions. It may be congenital or acquired. Acquired cases are mainly seen in oestrogen deficiency states in prepubertal girls and postmenopausal women. Read More

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November 2018

Percentage fractions of urinary di(2-ethylhexyl) phthalate metabolites: Association with obesity and insulin resistance in Korean girls.

PLoS One 2018 27;13(11):e0208081. Epub 2018 Nov 27.

Department of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Objective: We assessed the associations of percentage fractions of urinary di(2-ethylhexyl) phthalate (DEHP) metabolites with obesity and insulin resistance in Korean girls.

Methods: In total, 137 girls, aged 6 to 13 years (65 overweight cases and 72 controls), were recruited. Anthropometric indices and the homeostatic model assessment of insulin resistance (HOMA-IR) index were determined. Read More

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November 2018
5 Reads

Effect of growth hormone treatment on energy expenditure and its relation to first-year growth response in children.

Eur J Appl Physiol 2018 Nov 26. Epub 2018 Nov 26.

Department of Paediatric Endocrinology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: The effects of growth hormone (GH) treatment on linear growth and body composition have been studied extensively. Little is known about the GH effect on energy expenditure (EE). The aim of this study was to investigate the effects of GH treatment on EE in children, and to study whether the changes in EE can predict the height gain after 1 year. Read More

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November 2018
1 Read

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats.

J Ovarian Res 2018 Nov 26;11(1):99. Epub 2018 Nov 26.

Department of Anatomy, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective of this study is to evaluate the potential protective roles of Ficus deltoidea against BPA-induced toxicity of the pituitary-ovarian axis in pre-pubertal female rats. In this study, four groups of pre-pubertal female Sprague Dawley rats were administered with the followings by oral gavage for a period of six weeks: NC (negative control- treated with vehicle), PC (positive control-treated with BPA at 10 mg/kg/BW), F (treated with Ficus deltoidea at 100 mg/kg/BW, then exposed to BPA at 10 mg/kg/BW) and FC (Ficus deltoidea control - treated with Ficus deltoidea at 100 mg/kg/BW). Read More

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November 2018

Ultrasonographic evaluation of ovarian morphology and blood flow in prepubertal and pubertal cats.

Reprod Domest Anim 2018 Nov;53 Suppl 3:74-78

Laboratory of Reproductive Physiology, Faculty of Veterinary Sciences, National University of La Plata (FVS-NULP), La Plata, Argentina.

The aim of this study was to evaluate two-dimensional and Doppler ultrasonographic changes of feline ovaries before and during puberty. Nine, 3-month-old female cats were followed until puberty (Day 1). Two-dimensional and Doppler ultrasound evaluations of the ovaries were carried out on Days -50, -20, -7 and 1. Read More

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November 2018

Continuous access to snacks from weaning onwards in female rats causes weight gain, insulin insensitivity, and sustained leptin resistance in adulthood.

Physiol Behav 2018 Nov 22. Epub 2018 Nov 22.

Washington and Lee University, Department of Biology, Howe 301, 204 W. Washington Street, Lexington, VA 24450, USA. Electronic address:

A large part of the daily intake of children in the U.S. consists of snacks, with the average child consuming three snacks per day. Read More

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November 2018
1 Read

Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORαin cumulus cells of prepubertal lambs.

Free Radic Biol Med 2018 Nov 22. Epub 2018 Nov 22.

Animal Husbandry and Veterinary Research Institute of Tianjin, Tianjin 300412, China. Electronic address:

Physical damage and oxidative stress may occur in prepubertal cumulus cells, due to insufficient glutathione synthesis. To determine potential epigenetic mechanisms related to antioxidant effects of melatonin on ovine prepubertal cumulus cells, 30 lambs, 4-wk-old were randomly allocated into two groups: a control (C, n=20) group and a melatonin (M, n=10) group given a subcutaneous implant containing 18mg melatonin. All lambs were superovulated (250 IU FSH and 250 IU eCG). Read More

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November 2018

The impact of asthma and its treatment on growth: an evidence-based review.

J Pediatr (Rio J) 2018 Nov 22. Epub 2018 Nov 22.

Pontificia Universidad Católica de Chile, Faculdade de Medicina, Divisão de Pediatria, Unidade de Pneumologia Pediátrica, Santiago, Chile.

Objectives: To assess the impact of asthma and its treatment (inhaled corticosteroids and other control medications) on growth.

Data Sources: The authors searched PubMed (up to August 24, 2018) and screened the reference lists of retrieved articles. Systematic reviews and meta-analysis were selected. Read More

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November 2018
2 Reads

Effect of hormone modulations on donor-derived spermatogenesis or colonization after syngeneic and xenotransplantation in mice.

Andrology 2018 Nov 23. Epub 2018 Nov 23.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Cytotoxic cancer treatments, such as irradiation, can cause permanent sterility in male mammals owing to the loss of spermatogonial stem cells. In animal models, spermatogenesis could be restored from transplanted spermatogonial stem cells. Previously, we showed that transient suppression of FSH, LH, and testosterone in the recipient with a gonadotropin-releasing hormone antagonist (GnRH-ant), given immediately after irradiation, enhanced spermatogenesis from transplanted spermatogonial stem cells in mice and monkeys. Read More

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November 2018
2 Reads

Deciphering the transcriptome of prepubertal buffalo mammary glands using RNA sequencing.

Funct Integr Genomics 2018 Nov 23. Epub 2018 Nov 23.

School of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, 141004, India.

Although water buffaloes are the main milk-producing animals in Indian subcontinent, only limited attempts have been made to identify canonical pathways and gene regulatory networks operating within the mammary glands of these animals. Such information is important for identifying unique transcriptome signatures in the mammary glands of diseased animals. In this report, we analyzed the transcription profile of 3 prepubertal buffalo mammary glands and identified common genes (mean FPKM > 0. Read More

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November 2018

Biopolymer gels as a basis of cryoprotective medium for testicular tissue of rats.

Cell Tissue Bank 2018 Dec 21;19(4):819-826. Epub 2018 Nov 21.

Department of Cryopathophysiology and Immunology, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine.

Cryopreservation of testis tissue is a promising approach to save fertility in prepubertal boys under going gonadotoxic cancer therapies. The using biopolymers as a basis of cryoprotective medium can be effective for the optimization of cryopreservation protocols of immature testicular tissue. The research purpose was to determine morphological parameters and metabolic activity of seminiferous tubules of immature rat testes under exposure to cryoprotective solution (DMSO) based on collagen or fibrin gels (CG or FG) as one of the first stages of developing the cryopreservation protocol. Read More

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December 2018
1 Read

Geometric morphometrics on juvenile crania: Exploring age and sex variation in an Australian population.

Forensic Sci Int 2018 Nov 3;294:57-68. Epub 2018 Nov 3.

Centre for Forensic Anthropology, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, Australia. Electronic address:

For medico-legal forensic practitioners the identification of unknown remains is an important part of any investigation, often predicated on having accurate estimations of age and sex. In considering the specific skeletal elements available to facilitate such biological information, the cranium is frequently targeted for analysis, as it exhibits marked traits of sexual dimorphism, and also has a predictable pattern of growth. There are, however, instances where it may not be possible to estimate skeletal sex, especially in the juvenile skeleton. Read More

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November 2018
1 Read

Molecular mechanism of mammary gland involution: An update.

Dev Biol 2018 Nov 15. Epub 2018 Nov 15.

Animal Biotechnology Centre, National Dairy Research Institute (NDRI), Karnal 132001, India. Electronic address:

The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway of lactation - involution - lactation, fine-tuning these molecular events through hormones, growth factors and other regulatory molecules. The developmental stages of the MG are embryonic, prepubertal, pubertal, pregnancy, lactation and involution, with major developmental processes occurring after puberty. Read More

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November 2018
17 Reads

Cryostorage of testicular tissue and retransplantation of spermatogonial stem cells in the infertile male.

Best Pract Res Clin Endocrinol Metab 2018 Nov 3. Epub 2018 Nov 3.

Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Avenue Mounier 52, 1200 Brussels, Belgium. Electronic address:

Transplantation of own cryostored spermatogonial stem cells (SSCs) is a promising technique for fertility restoration when the SSC pool has been depleted. In this regard, cryopreservation of pre-pubertal testicular tissue or SSCs suspensions before gonadotoxic therapies is ethically accepted and increasingly proposed. SSC transplantation has also been considered to treat other causes of infertility relying on the possibility of propagating SSCs retrieved in the testes of infertile men before autologous re-transplantation. Read More

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November 2018
1 Read

Vulvar lichen sclerosus in a prepubertal girl.

Oxf Med Case Reports 2018 Dec 12;2018(12):omy104. Epub 2018 Nov 12.

Paediatrics Department, Hospital Dr. Nélio Mendonça, Funchal, Portugal.

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December 2018

Effects of 8-Week Functional vs. Traditional Training on Athletic Performance and Functional Movement on Prepubertal Tennis Players.

J Strength Cond Res 2018 Nov 13. Epub 2018 Nov 13.

Department of Coaching Education, Faculty of Sport Sciences, Sakarya Uygulamali Bilimler University, Sakarya, Turkey.

Yildiz, S, Pinar, S, and Gelen, E. Effects of 8-week functional vs. traditional training on athletic performance and functional movement on prepubertal tennis players. Read More

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November 2018
4 Reads

Delayed Puberty by Ziram Is Associated with Down Regulation of Testicular Phosphorylated AKT1 and SIRT1/PGC-1α Signaling.

Chem Res Toxicol 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , 109 Xueyuan West Road , Wenzhou , Zhejiang 325027 , China.

Ziram is a dimethyldithiocarbamate fungicide, which may influence the male reproductive system as a potential endocrine disruptor. We interrogated the disruption of ziram on rat progenitor Leydig cell development. Prepubertal male Sprague-Dawley rats were orally treated with 0, 2, 4, or 8 mg/kg ziram for 2 weeks. Read More

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November 2018
4 Reads
3.530 Impact Factor

Circulating irisin levels in children with growth hormone (GH) deficiency before and after 1 year of GH treatment.

J Clin Endocrinol Metab 2018 Nov 9. Epub 2018 Nov 9.

Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Italy.

Purpose: To evaluate circulating irisin levels in children with growth hormone deficiency (GHD) and any relation with clinical and metabolic parameters.

Patients: Fifty-four prepubertal children (mean age 7.4 ± 0. Read More

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November 2018
1 Read

Formation and activation induction of primordial follicles using granulosa and cumulus cells conditioned media.

J Cell Physiol 2018 Nov 11. Epub 2018 Nov 11.

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Fertility preservation of prepubertal girls subjected to invasive cancer therapy necessitates defining protocols for activation of isolated primordial follicles. Granulosa (GCs) and cumulus cells (CCs) play pivotal role in oocyte development. Although GCs and CCs share some similarities, they differ in growth factors production. Read More

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November 2018
17 Reads

Parental Perceptions of Emotional and Behavioral Difficulties Among Prepubertal Gender-Nonconforming Children.

Clin Pract Pediatr Psychol 2017 Dec;5(4):342-352

Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Northwestern University Feinberg School of Medicine.

The purpose of this study was to better understand parents' perceptions of how, if at all, their transgender and gender-nonconforming (TGNC) children exhibited common childhood emotional and behavioral concerns in relation to gender nonconformity/gender dysphoria (GD), and to identify ways in which evidence-based interventions (EBI) targeting emotional and behavioral concerns could be adapted to best serve TGNC children. Qualitative data were gathered from a targeted focus group activity with 40 parents (25 mothers, 15 fathers) of 24 TGNC children ages 4-11 years old. Parents of TGNC children described how 4 prespecified domains of emotional and behavioral problems (i. Read More

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December 2017
3 Reads

Estrogen modulates ethanol-induced memory deficit in postpubertal adolescent rats.

Authors:
Ratna Sircar

Alcohol Clin Exp Res 2018 Nov 8. Epub 2018 Nov 8.

Department of Psychology, The City College of New York, CUNY, New York, NY.

Background: Our laboratory and others have reported that ethanol impairs hippocampus-associated memory formation in prepubertal adolescent rats. Acute alcohol exposure in humans produces a syndrome of memory loss ("blackouts") that is similar to impairments caused by hippocampal damage. The ability to form new long-term explicit memories is affected but not short-term memory storage or recall of information from long-term storage. Read More

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November 2018
3 Reads

Influence of warming and reanimation conditions on seminiferous tubule morphology, mitochondrial activity, and cell composition of vitrified testicular tissues in the domestic cat model.

PLoS One 2018 8;13(11):e0207317. Epub 2018 Nov 8.

Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC, United States of America.

Understanding critical roles of warming and reanimation is critical to improve the survival of vitrified testicular tissue in domestic cats. The objective was to study structural and functional properties of testicular tissues from prepubertal domestic cats after standard vitrification followed by two warming protocols (directly at 37°C or with a 5-second pre-exposure to 50°C) and three reanimation time points (immediately, 24 h and 5 days post-warming). In Experiment 1, tissues were evaluated for histo-morphology and mitochondrial activity immediately or 24 h after warming protocols. Read More

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November 2018

How does chemotherapy treatment damage the prepubertal testis?

Reproduction 2018 Oct 1. Epub 2018 Oct 1.

N Spears, Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

Chemotherapy treatment is a mainstay of anticancer regimens, significantly contributing to the recent increase in childhood cancer survival rates. Conventional cancer therapy not only targets malignant but also healthy cells resulting in side effects including infertility. For prepubertal boys, there are currently no fertility preservation strategies in use, although several potential methods are under investigation. Read More

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October 2018

Profile of LH release in response to intramuscular treatment with kisspeptin in Bos indicus and Bos taurus prepubertal heifers.

Theriogenology 2018 Oct 19;125:64-70. Epub 2018 Oct 19.

School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:

The main objective of this study was to evaluate the effect of intramuscular (I.M.) administration of different doses of kisspeptin (Kp) on the pattern of luteinizing hormone (LH) release in Bos taurus and Bos indicus prepubertal heifers. Read More

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October 2018
1 Read

Association of prepubertal obesity with pubertal development in Chinese girls and boys: A longitudinal study.

Am J Hum Biol 2018 Nov 2:e23195. Epub 2018 Nov 2.

Department of Community and Family Medicine and Duke Global Health Institute, Duke University, Durham, North Carolina.

Objectives: The purpose of this study was to examine the association of prepubertal body mass index (BMI) and weight status with pubertal development in boys and girls in Chongqing, China.

Methods: In a longitudinal study, 1237 students (695 boys and 542 girls) were recruited from Chongqing, China, and examined at baseline, then followed every 6 months for three and a half years. Height, weight, testicular volume, and breast development were measured at every examination. Read More

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November 2018
2 Reads

Treatment Prepubertal Labial Adhesions: A Randomized Controlled Trial.

J Pediatr Adolesc Gynecol 2018 Oct 29. Epub 2018 Oct 29.

Department of Surgery, Children's Mercy Hospitals, Kansas City, Missouri; Department of Obstetrics and Gynecology, University of Missouri-Kansas City, Kansas City, Missouri.

Study Objective: Although various treatment options have been proposed for the treatment of labial adhesions, there are currently no clearly outlined limits on the duration of topical therapy, amount of lateral traction to apply, and methods to decrease the recurrence. This clinical trial was undertaken to assess the need for estrogen for treatment of prepubertal labial adhesions.

Design: Randomized, double-blinded, controlled trial. Read More

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October 2018
2 Reads

Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria.

Int J Pediatr Endocrinol 2018 22;2018. Epub 2018 Oct 22.

The BElgian Society for PEdiatric Endocrinology and Diabetology (BESPEED), Laarbeeklaan 101, 1090 Brussels, Belgium.

Background: There is no consensus on the definition of poor growth response after the first year of growth hormone (GH) treatment. We determined the proportion of poor responders identified by different criteria in children with GH deficiency (GHD) and born small for gestational age (SGA). The second aim was to analyze the IGF-1 response in poor growth responders. Read More

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October 2018
2 Reads

Ultrasound as a method to evaluate the distribution of abdominal fat in obese prepubertal children and the relationship between abdominal fat and metabolic alterations.

Radiol Bras 2018 Sep-Oct;51(5):293-296

Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.

Abstract.

Objective: To evaluate, using ultrasound, the distribution of abdominal fat in obese prepubertal children, as well as its possible correlation with metabolic changes due to obesity.

Materials And Methods: This was a cross-sectional study of prepubescent children: 77 obese children (33 girls and 44 boys), with a mean age of 7. Read More

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October 2018

Effect of honey on glucose and insulin concentrations in obese girls.

Eur J Clin Invest 2018 Oct 28:e13042. Epub 2018 Oct 28.

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, Athens, Greece.

Background: Childhood obesity represents a major health problem of our century. The benefits of natural products, such as honey, in the management of obesity have gained renewed interest. In this study, we investigated the effect of honey on glucose and insulin concentrations in obese prepubertal girls. Read More

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October 2018
5 Reads

Nasal function before and after rapid maxillary expansion in children: A randomized, prospective, controlled study.

Int J Pediatr Otorhinolaryngol 2018 Dec 28;115:133-138. Epub 2018 Sep 28.

Department of Neurosciences DNS, Odontostomatology Institute, University of Padova, Padova, Italy.

Objectives: Children can well detect and respond to odours in order to have information about food and environment. Rapid Maxillary Expansion seems to improve dental and skeletal crossbite and increase nasal patency correcting oral respiration in children. A previous pilot study suggested that Rapid Maxillary Expansion may lead to improved N-Butanol olfactory thresholds, and peak nasal inspiratory flow values (PNIF). Read More

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December 2018
2 Reads

Testicular teratomas: a growing problem?

Med Oncol 2018 Oct 26;35(12):153. Epub 2018 Oct 26.

Department of Uro-oncology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 5, Roentgen Street, 02-781, Warsaw, Poland.

Testicular teratomas represent a specific entity within the group of germ-cell tumours. They may comprise elements of all three germ layers. In contrast to prepubertal benign teratomas observed in infants and adolescents, postpubertal teratomas originate from the malignant germ-cell precursor. Read More

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October 2018
2 Reads

Management of High-grade, Nonmuscle Invasive Urothelial Carcinoma in a Prepubertal Patient With TURBT and Intravesical BCG.

Urology 2018 Oct 24. Epub 2018 Oct 24.

Harvard Medical School, Department of Surgery and Boston Children's Hospital, Department of Urology, Boston, MA. Electronic address:

High-grade urothelial carcinoma of the bladder is rare in the pediatric population with no established guidelines for management. We treated a single female patient, 10 years of age, who was found to have high-grade, nonmuscle invasive urothelial carcinoma endoscopically and with intravesical bacille calmette guerin (BCG). Given the child's age, no local adult institution could provide BCG therapy. Read More

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October 2018
5 Reads

Donor spermatogenesis in de novo formed seminiferous tubules from transplanted testicular cells in rhesus monkey testis.

Hum Reprod 2018 Dec;33(12):2249-2255

Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Study Question: Can transplanted primate testicular cells form seminiferous tubules de novo, supporting complete spermatogenesis?

Summary Answer: Cryopreserved testicular cells from a prepubertal monkey can reorganize in an adult monkey recipient testis forming de novo seminiferous tubular cords supporting complete spermatogenesis.

What Is Known Already: De novo morphogenesis of testicular tissue using aggregated cells from non-primate species grafted either subcutaneously or in the testis can support spermatogenesis.

Study Design, Size, Duration: Two postpubertal rhesus monkeys (Macaca mulatta) were given testicular irradiation. Read More

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December 2018
7 Reads

Haploid Germ Cells Generated in Organotypic Culture of Testicular Tissue From Prepubertal Boys.

Front Physiol 2018 9;9:1413. Epub 2018 Oct 9.

Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

While in mice various studies have described the completion of spermatogenesis using either organotypic culture of prepubertal testicular tissue or 3D culture of isolated cells, in humans it has not been possible to achieve germ cell differentiation from immature testicular tissue (ITT). In our study, we evaluated the ability of human ITT to differentiate via a long-term organotypic culture of frozen-thawed 1 mm testicular fragments from five prepubertal boys in two different culture media. Tissue and supernatants were analyzed at regular intervals up to day 139. Read More

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October 2018
4 Reads

Effect of adherence to growth hormone treatment on 0-2 year catch-up growth in children with growth hormone deficiency.

PLoS One 2018 24;13(10):e0206009. Epub 2018 Oct 24.

Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.

Background: Quantifying the association between adherence and the growth response to growth hormone (GH) treatment is hampered by suboptimal methods of measuring adherence, confounders associated with the growth response, and restriction of the outcome parameters to yearly growth velocities.

Aim: To investigate the effect of adherence on the two-year growth response to GH treatment in prepubertal children with idiopathic isolated growth hormone deficiency (GHD) participating in the easypod connect observational study (ECOS), a 5-year, Phase IV open-label study to continuously assess real-world adherence via the easypod electronic drug-delivery device.

Patients And Methods: Outcome measures were change in height standard deviation score (ΔHSDS), index of responsiveness (IoR), and parameters of two catch-up growth (CUG) curve functions (monomolecular growth curve and second degree polynomial) with adj-HSDS (HSDS minus Target height (TH) SDS) as dependent variable. Read More

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October 2018
3 Reads

Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements.

Sci Rep 2018 Oct 24;8(1):15691. Epub 2018 Oct 24.

Endocrine Unit, "Aretaieion" Hospital, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (46 IUGR and 52 AGA), subdivided in <5 years and >5 years old groups were included. Read More

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October 2018
5 Reads

Childhood Fat and Lean Mass: Differing Relations to Vascular Structure and Function at Age 8 to 9 Years

Arterioscler Thromb Vasc Biol 2018 10;38(10):2528-2537

NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom (H.M.I., K.M.G., C.C, M.H.).

Objective- Childhood body mass index (BMI) has been related to vascular structure and function. However, little is known about the differing contributions of fat and lean mass to this relationship. Our objectives were to relate the fat and lean mass (bone excluded) components of BMI (fat mass index and lean mass index; mass [kg]/height [m]) to vascular measures in prepubertal children. Read More

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October 2018

[Andrology in oncological diseases].

Hautarzt 2018 Dec;69(12):977-983

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Deutschland.

In dermato-oncological treatment there are many gonadotoxic interventions. Alkylating and hormonally active substances as well as gonadal irradiation, in particular, are known to have a fertilization-limiting effect in men. Since 2017 certified skin cancer centers in Germany therefore have the task to implement counselling on preservation of fertility. Read More

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December 2018

Higher steroid sulfation is linked to successful weight loss in obese children.

Endocr Connect 2018 Oct;7(10):1020-1030

Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany.

Objective Little information is available on the steroid sulfates profile in obese children. Therefore, we examined whether sulfated steroids are linked with weight status and associated comorbidities in obese children. Methods We analyzed 66 obese children (mean age 10. Read More

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October 2018
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Developmental and family history-based analysis of congenital fused labia phenotype in the captive common marmoset (Callithrix jacchus).

J Med Primatol 2018 Oct 23. Epub 2018 Oct 23.

Laboratory of Biomedical Reproduction, German Primate Centre, Goettingen, Germany.

Background: Congenital fused labia (CFL) is defined as a failure or significant delay in the opening of the juvenile sealed labia majora. This phenotype is known to be variably common in adult captive female marmosets but has never been investigated in detail before.

Materials And Methods: Here, we define, describe and quantify the variations in the degree of closure of the vulva in 122 captive marmosets (Callithrix jacchus) from 1. Read More

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October 2018