6,325 results match your criteria Preoperative Testing


The negative predictive value of preoperative urodynamics for stress urinary incontinence following prolapse surgery.

Int Urogynecol J 2019 Jan 14. Epub 2019 Jan 14.

Division of Urogynecology and Reconstructive Pelvic Surgery, University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA, 01605, USA.

Introduction And Hypothesis: There is no consensus for the evaluation of stress urinary incontinence (SUI) in patients planning pelvic organ prolapse (POP) surgery. We sought to determine the negative predictive value (NPV) of prolapse reduction during preoperative urodynamics (UDS) for postoperative SUI.

Methods: We performed a retrospective study of 322 women with preoperative UDS and subsequent POP surgery. Read More

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http://dx.doi.org/10.1007/s00192-018-03864-yDOI Listing
January 2019

Routine Preoperative Coagulation Tests in Children Undergoing Elective Surgery or Invasive Procedures: Are They Still Necessary?

Clin Med Insights Blood Disord 2019 5;12:1179545X18821158. Epub 2019 Jan 5.

Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction: Preoperative coagulation screening tests in pediatric patients was once routine clinical practice globally and still used as standard practice in some countries before surgical procedures to assess of perioperative bleeding risk.

Objective: The study aimed to evaluate unselected routine preoperative coagulation testing in children undergoing elective or invasive surgery to predict abnormal perioperative bleeding. The study also aimed to provide a rational approach of determining bleeding and family history of coagulation disorders as a predictive risk for bleeding. Read More

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http://dx.doi.org/10.1177/1179545X18821158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322095PMC
January 2019

Preoperative measures to prevent/minimize risk of surgical site infection in spinal surgery.

Authors:
Nancy E Epstein

Surg Neurol Int 2018 11;9:251. Epub 2018 Dec 11.

Clinical Professor of Neurological Surgery, School of Medicine, State University of N.Y. at Stony Brook, and Chief of Neurosurgical Spine/Education at NYU Winthrop Hospital, Mineola, NY 11501, USA.

Background: Multiple measures prior to spine surgery may reduce the risks of postoperative surgical site infections (SSIs).

Methods: The incidence of SSI following spinal surgery (including reoperations and readmissions) may be markedly reduced by performing less extensive procedures and avoiding fusion where feasible. Preoperative testing up to 3 weeks postoperatively should include other studies to limit the perioperative SSI risk; cardiac stress tests (e. Read More

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http://dx.doi.org/10.4103/sni.sni_372_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302553PMC
December 2018

Predicting EGFR Mutation Status in Lung Adenocarcinoma on CT Image Using Deep Learning.

Eur Respir J 2019 Jan 11. Epub 2019 Jan 11.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Epidermal Growth Factor Receptor (EGFR) genotyping is critical for treatment guideline such as the use of tyrosine kinase inhibitors in lung adenocarcinoma (LA). Conventional identification of EGFR genotype requires biopsy and sequence testing that is invasive and may suffer from the difficulty in accessing tissue samples. Here, we proposed a deep learning (DL) model to predict the EGFR mutation status in LA by non-invasive computed tomography (CT). Read More

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http://dx.doi.org/10.1183/13993003.00986-2018DOI Listing
January 2019

Bilaterally Asymmetric Corneal Ectasia Following SMILE With Asymmetrically Reduced Stromal Molecular Markers.

J Refract Surg 2019 Jan;35(1):6-14

Purpose: To evaluate extracellular matrix regulators and inflammatory factors in a patient who developed ectasia after small incision lenticule extraction (SMILE) despite normal preoperative tomographic and biomechanical evaluation.

Methods: The SMILE lenticules from both eyes of the patient with ectasia and three control patients (5 eyes) matched for age, sex, and duration of follow-up were used for gene expression analysis of lysyl oxidase (LOX), matrix metalloproteinase 9 (MMP9), collagen types I alpha 1 (COLIA1) and IV alpha 1 chain (COLIVA1), transforming growth factor-beta (TGF-beta), bone morphogenetic protein 7 (BMP7), interleukin-6 (IL-6), cathepsin K, cluster of differentiation 68, integrin beta-1, and tissue inhibitor of metalloproteinase-1 (TIMP1). Furthermore, the functional role of LOX was assessed in vitro by studying the collagen gel contraction efficiency of LOX overexpressing in primary human corneal fibroblast cells. Read More

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https://www.healio.com/doiresolver?doi=10.3928/1081597X-2018
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http://dx.doi.org/10.3928/1081597X-20181128-01DOI Listing
January 2019
1 Read

Preoperative pulmonary function testing and postoperative complications.

J Thorac Dis 2018 Nov;10(Suppl 33):S3840-S3842

Department of General Thoracic Surgery, Sagamihara Kyodo Hospital, Sagamihara, Kanagawa, Japan.

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http://jtd.amegroups.com/article/view/24131/18949
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http://dx.doi.org/10.21037/jtd.2018.09.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297482PMC
November 2018
1 Read

When Preoperative Imaging and Audiometry Conflict: A Case of Cochlear Implantation in a Prelingually Deafened Adult.

Otol Neurotol 2019 Feb;40(2):e89-e93

Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia.

Objective: To describe a unique case of excellent audiometric outcomes for a prelingually deafened adult after cochlear implantation and to caution on the limits of magnetic resonance imaging for a diagnosis of cochlear nerve aplasia.

Patient: Adult man with congenital bilateral profound sensorineural hearing loss.

Intervention (s): Cochlear implantation. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002085DOI Listing
February 2019

The added value of orthotic management in the context of multi-level surgery in children with cerebral palsy.

Gait Posture 2019 Jan 6;68:525-530. Epub 2019 Jan 6.

Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstr. 200, 69118, Heidelberg, Germany.

Background: Treatment of cerebral palsy includes an interdisciplinary concept and in more severe cases the well-established multi-level surgery (MLS). Different kinds of orthoses are typically part of postoperative treatment but there is a lack of knowledge about their additional benefit.

Research Question: Do ankle foot orthoses lead to an additional, measurable improvement of gait after MLS?

Methods: 20 children with bilateral spastic cerebral palsy (9 retrospective, 11 in a postoperative clinical routine) were included. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.01.006DOI Listing
January 2019
1 Read

Centrifuged supernatants from FNA provide a liquid biopsy option for clinical next-generation sequencing of thyroid nodules.

Cancer Cytopathol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Molecular testing is recommended as an adjunct to improve the preoperative diagnosis of fine-needle aspiration (FNA) of thyroid nodules. Centrifuged supernatants from FNA samples, which are typically discarded, have recently emerged as a novel liquid-based biopsy for molecular testing. This study evaluates the use of thyroid FNA supernatants for detecting clinically relevant mutations. Read More

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http://dx.doi.org/10.1002/cncy.22098DOI Listing
January 2019

Texture analysis on conventional MRI images accurately predicts early malignant transformation of low-grade gliomas.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Weill Cornell Medicine, 407 E 61st Street Suite 107, New York, NY, 10065, USA.

Objectives: Texture analysis performed on MRI images can provide additional quantitative information that is invisible to human assessment. This study aimed to evaluate the feasibility of texture analysis on preoperative conventional MRI images in predicting early malignant transformation from low- to high-grade glioma and compare its utility to histogram analysis alone.

Methods: A total of 68 patients with low-grade glioma (LGG) were included in this study, 15 of which showed malignant transformation. Read More

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http://dx.doi.org/10.1007/s00330-018-5921-1DOI Listing
January 2019

Routine preoperative medical testing for cataract surgery.

Cochrane Database Syst Rev 2019 Jan 8;1:CD007293. Epub 2019 Jan 8.

The George Institute for Global Health, The University of Sydney, Level 24, Maritime Trade Towers, 207 Kent Street, Sydney, NSW, Australia, 2000.

Background: Cataract surgery is practiced widely, and substantial resources are committed to an increasing cataract surgical rate in low- and middle-income countries. With the current volume of cataract surgery and future increases, it is critical to optimize the safety and cost-effectiveness of this procedure. Most cataracts are performed on older individuals with correspondingly high systemic and ocular comorbidities. Read More

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http://dx.doi.org/10.1002/14651858.CD007293.pub4DOI Listing
January 2019

Clinical investigation of gustatory and neurosensory alterations following mandibular third molar surgery: an observational prospective study.

Clin Oral Investig 2019 Jan 6. Epub 2019 Jan 6.

Division of Oral and Maxillofacial Surgery, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Brazil.

Objective: This study aimed to prospectively observe gustatory and neurosensory alterations following surgical removal of mandibular third molars.

Material And Methods: A prospective clinical study was conducted with patients who required mandibular third molar extraction, recruited from the Division of Oral and Maxillofacial Surgery at the Federal University of Ceará (Brazil). Age, sex, and radiographic signs were recorded. Read More

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http://dx.doi.org/10.1007/s00784-018-02798-5DOI Listing
January 2019

Society for the Advancement of Blood Management Administrative and Clinical Standards for Patient Blood Management Programs. 4 Edition (Pediatric Version).

Paediatr Anaesth 2019 Jan 4. Epub 2019 Jan 4.

Department of Anesthesiology and Bloodless Medicine, Englewood Hospital and Medical Center, NJ, USA.

Patient Blood Management is the timely application of evidence-based medical and surgical concepts designed to maintain hemoglobin concentration, optimize hemostasis and minimize blood loss to improve patient outcomes. Conceptually similar to a "bundle" strategy, it is designed to improve clinical care by using comprehensive evidence-based treatment strategies to manage patients with potential or ongoing critical bleeding, bleeding diathesis, critical anemia and/ or a coagulopathy. Patient Blood Management includes multimodal strategies to screen, diagnose and properly treat anemia, coagulopathies and minimize bleeding, using goal-directed therapy and leverages a patient's physiologic ability to adapt to anemia while definitive treatment is undertaken. Read More

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http://dx.doi.org/10.1111/pan.13574DOI Listing
January 2019
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Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.

Horm Metab Res 2019 Jan 2. Epub 2019 Jan 2.

Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.

We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3-6 months, and 13 patients 12 months post-operatively. Read More

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http://dx.doi.org/10.1055/a-0801-8917DOI Listing
January 2019
2 Reads

The Abdominal Hernia-Q: Development, Psychometric Evaluation, and Prospective Testing.

Ann Surg 2018 Dec 26. Epub 2018 Dec 26.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA.

Objective: Our study completes the development and estimates the psychometric properties of a novel, ventral hernia-specific patient reported outcomes (PRO) tool-the Abdominal Hernia-Q (AHQ).

Summary Background Data: A standardized method for measuring hernia-related PRO has not been identified. There remains a need for a broadly applicable, hernia-specific tool that incorporates patient viewpoints and offers pre- and postoperative forms. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003144DOI Listing
December 2018
1 Read

The impact of reduction of testing at a Preoperative Evaluation Clinic for elective cases: Value added without adverse outcomes.

J Clin Anesth 2018 Dec 29;55:92-99. Epub 2018 Dec 29.

Department of Anesthesiology, Vanderbilt University School of Medicine, 4648 Vanderbilt University Hospital, Nashville, TN 37232, United States of America; Department of Biomedical Informatics, Vanderbilt University School of Medicine, 4648 Vanderbilt University Hospital, Nashville, TN 37232, United States of America.

Study Objective: Protocol changes at Vanderbilt have been adopted with the intention of reducing unnecessary preoperative testing. We sought to evaluate their success and association with clinical decisions.

Design: Retrospective Observational Study SETTING: Vanderbilt's Preoperative Evaluation Clinic MEASUREMENTS: We reviewed and identified a key interval of change on clinical workup protocols which led to a reduction in preoperative testing. Read More

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http://dx.doi.org/10.1016/j.jclinane.2018.12.027DOI Listing
December 2018

Negative pressure pulmonary edema postextubation following medial nerve repair with sural graft surgery in a young patient: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13743

The Ohio State University Wexner Medical Center, Department of Anesthesiology.

Rationale: Negative pressure pulmonary edema (NPPE) is a serious well-described pulmonary complication. It occurs after an intense inspiratory effort against an obstructed or closed upper airway and generates a large negative airway pressure, leading to severe pulmonary edema (transvascular fluid filtration and interstitial/alveolar edema) and hypoxemia. We present a case of NPPE following general anesthesia in a patient who underwent median nerve neurorrhaphy with graft from lower left limb (sural nerve) due to sharp injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000013743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314689PMC
December 2018
1 Read

Postoperative platelet function is associated with severe bleeding in ticagrelor-treated patients.

Interact Cardiovasc Thorac Surg 2018 Dec 22. Epub 2018 Dec 22.

Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Objectives: Preoperative testing of platelet function predicts bleeding risk in cardiac surgery patients treated with dual antiplatelet therapy, but the value of postoperative platelet function testing, reflecting both preoperative antiplatelet therapy and perioperative changes in platelet function, has not been evaluated.

Methods: Seventy-four patients with acute coronary syndrome treated with acetylsalicylic acid and ticagrelor within 5 days before cardiac surgery were included in a prospective observational study. Platelet aggregation induced by adenosine diphosphate, arachidonic acid and thrombin receptor-activating peptide was assessed with multiple electrode impedance aggregometry immediately before surgery and 2 h after weaning off cardiopulmonary bypass. Read More

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http://dx.doi.org/10.1093/icvts/ivy336DOI Listing
December 2018
1 Read

Surgical ablation of ventricular tachycardia in patients with repaired tetralogy of Fallot.

Eur J Cardiothorac Surg 2018 Dec 22. Epub 2018 Dec 22.

Department of Congenital Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Life expectancy of patients with repaired tetralogy of Fallot is normal until adulthood, when it becomes burdened by major complications such as cardiac arrhythmias and heart failure. Ventricular tachycardia (VT), associated with electrical conduction abnormalities in anatomical isthmuses, is the most common complication and is refractory to medical therapy. The arrhythmogenic sources can be surgically ablated during reoperations for pulmonary valve incompetence. Read More

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http://dx.doi.org/10.1093/ejcts/ezy407DOI Listing
December 2018
2 Reads

Baseline Lymphatic Dysfunction Amplifies the Negative Effects of Lymphatic Injury.

Plast Reconstr Surg 2019 Jan;143(1):77e-87e

New York, N.Y. From the Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center.

Background: Genetic mutations and obesity increase the risk of secondary lymphedema, suggesting that impaired lymphatic function before surgical injury may contribute to disease pathophysiology. Previous studies show that obesity not only decreases lymphatic function, but also markedly increases pathologic changes, such as swelling, fibroadipose deposition, and inflammation. However, although these reports provide circumstantial evidence supporting the hypothesis that baseline lymphatic defects amplify the effect of lymphatic injury, the mechanisms regulating this association remain unknown. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311716PMC
January 2019
5 Reads

Prediction of postoperative myocardial infarction after suprainguinal bypass using the Vascular Quality Initiative Cardiac Risk Index.

J Vasc Surg 2018 Dec 21. Epub 2018 Dec 21.

Division of Vascular and Endovascular Surgery, University of Massachusetts Medical School, Worcester, Mass. Electronic address:

Background: The Vascular Quality Initiative (VQI) Cardiac Risk Index (CRI) was developed to estimate the risk of postoperative myocardial infarction (POMI) for noncardiac vascular procedures. Whereas suprainguinal bypass carried the second highest odds of POMI, the performance of the all-procedure model declined when it was applied to the suprainguinal subset. We sought to improve the VQI CRI for application in this high-risk group undergoing open revascularization for aortoiliac occlusive disease. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.08.195DOI Listing
December 2018

Is Frozen Section Analysis During Thyroid Surgery Useful in the Era of Molecular Testing?

J Am Coll Surg 2018 Dec 21. Epub 2018 Dec 21.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background: With the increased use of molecular testing of thyroid fine-needle biopsies, the frequency and extent of thyroid resection for thyroid nodules has changed. While the role of frozen section analysis of the thyroid has been reduced markedly in recent years, many surgeons still routinely utilize this intraoperatively. We sought to determine the utility of frozen section during thyroidectomy in the era of molecular testing. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.002DOI Listing
December 2018

A randomised controlled trial to assess whether prehabilitation improves fitness in patients undergoing neoadjuvant treatment prior to oesophagogastric cancer surgery: study protocol.

BMJ Open 2018 Dec 22;8(12):e023190. Epub 2018 Dec 22.

The Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.

Introduction: Neoadjuvant therapy prior to oesophagogastric resection is the gold standard of care for patients with T2 and/or nodal disease. Despite this, studies have taught us that chemotherapy decreases patients' functional capacity as assessed by cardiopulmonary exercise (CPX) testing. We aim to show that a multimodal prehabilitation programme, comprising supervised exercise, psychological coaching and nutritional support, will physically, psychologically and metabolically optimise these patients prior to oesophagogastric cancer surgery so they may better withstand the immense physical and metabolic stress placed on them by radical curative major surgery. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318540PMC
December 2018
2 Reads

Variations in Utilization of Carpal Tunnel Release Among Medicaid Beneficiaries.

J Hand Surg Am 2018 Dec 19. Epub 2018 Dec 19.

VOICES Health Policy Research Center, Department of Orthopaedic Surgery, Stanford University, Redwood City, CA. Electronic address:

Purpose: To evaluate the null hypothesis that Medicaid patients receive carpal tunnel release (CTR) at the same time interval from diagnosis as do patients with Medicare Advantage or private insurance.

Methods: We conducted a retrospective review using a database containing claims records from 2007 to 2016. The cohort consisted of patient records with a diagnosis code of carpal tunnel syndrome (CTS) and a procedural code for CTR within 3 years of diagnosis. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.11.001DOI Listing
December 2018

Predictors of Future Contralateral Carpal Tunnel Release at the Time of Unilateral Surgery.

J Hand Surg Am 2018 Dec 19. Epub 2018 Dec 19.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: We assessed factors at the time of unilateral carpal tunnel release (CTR) for carpal tunnel syndrome to create a prediction formula for future CTR.

Methods: We retrospectively identified 1,013 patients who underwent CTR at a tertiary care referral center from July 2008 to June 2013. A multivariable logistic regression model was used to identify independent factors associated with future contralateral CTR. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.10.030DOI Listing
December 2018

Using the 6-minute walk test to predict disability-free survival after major surgery.

Br J Anaesth 2019 Jan 9;122(1):111-119. Epub 2018 Oct 9.

Alfred Hospital, Melbourne, VIC, Australia; Monash University, Melbourne, VIC, Australia.

Background: The 6-min walk test (6MWT) is a common means of functional assessment. Its relationship to disability-free survival (DFS) is uncertain.

Methods: This sub-study of the Measurement of Exercise Tolerance for Surgery study had co-primary outcome measures: correlation of the preoperative 6MWT distance with 30 day quality of recovery (15-item quality of recovery) and 12 month WHO Disability Assessment Schedule scores. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912183068
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http://dx.doi.org/10.1016/j.bja.2018.08.016DOI Listing
January 2019
1 Read

The anatomic location and importance of the tibialis posterior fascicular bundle at the sciatic nerve bifurcation: report of 3 cases.

J Neurosurg 2018 Dec 21:1-7. Epub 2018 Dec 21.

Departments of2Neurosurgery and.

The authors present the cases of 3 patients with severe injuries affecting the peroneal nerve combined with loss of tibialis posterior function (inversion) despite preservation of other tibial nerve function. Loss of tibialis posterior function is problematic, since transfer of the tibialis posterior tendon is arguably the best reconstructive option for foot drop, when available. Analysis of preoperative imaging studies correlated with operative findings and showed that the injuries, while predominantly to the common peroneal nerve, also affected the lateral portion of the tibial nerve/division near the sciatic nerve bifurcation. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181190DOI Listing
December 2018
3 Reads

Glioblastoma of the cerebellopontine angle and internal auditory canal mimicking a peripheral nerve sheath tumor: case report.

J Neurosurg 2018 Dec 21:1-5. Epub 2018 Dec 21.

Departments of1Neurologic Surgery.

Glioblastoma (GBM) of the internal auditory canal (IAC) is exceedingly rare, with only 3 prior cases reported in the literature. The authors present the fourth case of cerebellopontine angle (CPA) and IAC GBM, and the first in which the lesion mimicked a vestibular schwannoma (VS) early in its natural history. A 55-year-old man presented with tinnitus, hearing loss, and imbalance. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181702DOI Listing
December 2018
1 Read

[Early and long-term cognitive disorders after carotid endarterectomy].

Khirurgiia (Mosk) 2018 (12):5-12

Clinic of aortic and cardiovascular surgery of Sechenov University, Moscow, Russia.

Aim: To identify correlation of carotid endarterectomy with neurocognitive function and psycho-emotional state changes.

Material And Methods: There were 120 patients with internal carotid arteries (ICA) stenoses for the period from September 2013 to December 2016. The main group consisted of 100 patients undergoing carotid endarterectomy for internal carotid artery stenosis, control group - 20 patients who refused surgery in 2014-2016. Read More

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http://dx.doi.org/10.17116/hirurgia20181215DOI Listing
January 2018

Prolonged Activated Clotting Time Immediately Prior to Open Cardiac Surgery.

Ochsner J 2018 ;18(4):423-424

The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.

Background: Prekallikrein deficiency is an extremely rare disorder in which functional prekallikrein in the plasma is reduced or absent.

Case Report: We present the case of a 15-year-old male with prolonged activated clotting time incidentally noted preoperatively prior to repair of an atrial septal defect. The patient was subsequently found to have prekallikrein (Fletcher factor) deficiency. Read More

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http://dx.doi.org/10.31486/toj.18.0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292471PMC
January 2018
1 Read

Routine Postoperative Laboratory Tests Are Not Necessary After Primary Total Hip Arthroplasty.

J Arthroplasty 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT.

Background: Postoperative laboratory testing has been used routinely for patients undergoing total hip arthroplasty (THA). However, with modern-day improvements in perioperative care pathways, it is unclear whether this practice remains justified. The purpose of this study was to assess the utility of routine postoperative laboratory tests in primary THA. Read More

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http://dx.doi.org/10.1016/j.arth.2018.11.037DOI Listing
November 2018

Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial.

Trials 2018 Dec 17;19(1):688. Epub 2018 Dec 17.

Population Health Research Institute (PHRI), Hamilton Health Sciences, Hamilton, ON, Canada.

Background: A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy of an intervention, this approach is highly resource intensive and a cluster RCT can be more appropriate for testing clinical effectiveness in a real-world setting. Read More

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http://dx.doi.org/10.1186/s13063-018-3080-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296086PMC
December 2018

Undiagnosed hypertrophic obstructive cardiomyopathy during transcatheter aortic valve replacement: a case report.

J Med Case Rep 2018 Dec 18;12(1):372. Epub 2018 Dec 18.

Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA.

Background: Transcatheter aortic valve replacement is indicated for severe symptomatic aortic stenosis in patients who have a very high or prohibitive surgical risk as assessed pre-procedurally by the Society of Thoracic Surgery Risk Score, EuroSCORE (II), frailty testing, and other predictors. When combined with another left ventricular outflow tract obstruction, careful consideration must be taken prior to proceeding with transcatheter aortic valve replacement because an additional masked left ventricular outflow tract pathology can lead to challenging hemodynamics in the peri-deployment phase, as reported in this case.

Case Presentation: A 56-year-old Caucasian man with multiple comorbidities and severe aortic stenosis underwent transcatheter aortic valve replacement under monitored anesthesia care. Read More

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http://dx.doi.org/10.1186/s13256-018-1904-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298014PMC
December 2018
1 Read

Short-Term Outcomes Predict Long-Term Satisfaction in Patients Undergoing Laparoscopic Magnetic Sphincter Augmentation.

J Laparoendosc Adv Surg Tech A 2018 Dec 15. Epub 2018 Dec 15.

1 Department of Surgery, Mayo Clinic in Florida , Jacksonville, Florida.

Introduction: Laparoscopic magnetic sphincter augmentation (MSA) has been shown to be efficacious therapy for gastroesophageal reflux disease (GERD) refractory to maximal medical management. Herein, we present our experience with this procedure and an analysis of our outcomes.

Materials And Methods: Medical records were retrospectively reviewed of 98 patients who underwent laparoscopic MSA for GERD at a single institution from 2012 to 2016. Read More

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http://dx.doi.org/10.1089/lap.2018.0598DOI Listing
December 2018

Risk of post-operative hemorrhage after adenoidectomy and tonsillectomy: Value of the preoperative determination of partial thromboplastin time and prothrombin time.

Int J Pediatr Otorhinolaryngol 2019 Jan 19;116:62-64. Epub 2018 Oct 19.

Department of Otolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Introduction: Tonsillectomy and adenoidectomy (T& A) are the most common pediatric surgical procedures performed world-wide. Bleeding remains the most common complication of these procedures with 1-5.7% prevalence. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.10.024DOI Listing
January 2019

Disc Geometry Is an Accurate Predictor of Lordotic Correction in the Thoracolumbar Spine Following Schwab Grade 2 Osteotomy: A Cadaveric Study and Biomechanical Analysis of Disc Space Changes Following Lordotic Correction.

Oper Neurosurg (Hagerstown) 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Background: Posterior column osteotomy (PCO) is a powerful technique for correcting lordosis, but the surgical literature lacks objective evidence on preoperative predictors of achievable lordotic correction following PCO.

Objective: To measure the correlation between disc geometry and achievable lordotic correction following Schwab grade 2 osteotomies and to describe geometric changes to disc space following lordotic correction.

Methods: Schwab grade 2 osteotomies were performed from T1 to S1 in 5 cadavers. Read More

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http://dx.doi.org/10.1093/ons/opy362DOI Listing
December 2018

Cognitive self-assessment scales in surgical settings: Acceptability and feasibility.

Best Pract Res Clin Anaesthesiol 2018 Sep - Dec;32(3-4):303-309. Epub 2018 Aug 9.

The Ohio State University, Wexner Medical Center, Department of Anesthesiology, Columbus, OH, USA; The Ohio State University, Wexner Medical Center, Department of Neurological Surgery, Columbus, OH, USA.

Pre-existing cognitive impairment is associated with poor surgical outcomes, long hospital stays, and increased morbidity and mortality. This necessitates the use of screening tools to evaluate preoperative cognitive status in elderly surgical patients. Given the growing population of older adults and increased prevalence of cognitive impairment, it is necessary to investigate whether staff-administered or self-administered cognitive screening examinations provide more sensitive information about pre-existing (preoperative) cognitive status. Read More

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http://dx.doi.org/10.1016/j.bpa.2018.08.001DOI Listing
August 2018
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[Initial follow-up and CD(4)(+) T cell count test of newly reported students HIV cases in China, 2013-2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Dec;52(12):1254-1258

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze first follow-up and CD(4)(+) T (CD(4)) cell count test of newly reported students HIV cases in China from 2013 to 2017. Data were collected from both Case Reporting Cards and Follow-up Cards from China Information System for HIV/AIDS Control and Prevention between 1(s)t January 2013 and 31(st) December 2017. The inclusion criteria are 15-24 years old students who were newly diagnosed with HIV infection. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.12.012DOI Listing
December 2018

[Analysis on late HIV diagnosis among newly reported human immunodeficiency virus/acquired immunodeficiency syndrome cases between 2009 and 2017 in medical institutions].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Dec;52(12):1248-1253

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze the proportion of late HIV diagnosis and the factors associated with late HIV diagnosis of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) cases newly reported by medical institutions in China from 2009 to 2017. Data of adult HIV/AIDS cases newly reported by medical institutions in China from 2009 to 2017 were downloaded from the AIDS prevention and control information system of China's disease prevention and control information system. The basic information, sample source, transmission route, flow of HIV/AIDS patients and the first CD4(+) T lymphocyte count were analyzed in 293 187 cases who had been tested for CD4(+) T lymphocyte count within 91 days of diagnosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.12.011DOI Listing
December 2018

Predictive Value of Preoperative Magnetic Resonance Imaging Findings for Survival and Local Recurrence in Patients Undergoing En Bloc Resection of Sacral Chordomas.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Few studies have assessed the prognostic importance of preoperative magnetic resonance imaging (MRI) scan findings in patients undergoing en bloc resection of sacral chordomas.

Objective: To (1) report in-depth imaging characteristics of sacral chordomas, (2) describe the patterns of local and distant recurrence, and (3) determine imaging predictors of overall survival (OS) and local recurrence (LR).

Methods: This retrospective case series was obtained from a prospectively maintained spine database from 1995 to 2016. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyy578DOI Listing
December 2018
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Prevention of Early Postoperative Decline (PEaPoD): protocol for a randomized, controlled feasibility trial.

Trials 2018 Dec 11;19(1):676. Epub 2018 Dec 11.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

Background: Delirium is associated with a significantly increased risk of postoperative morbidity and mortality. Furthermore, delirium has been associated with an increased risk of prolonged cognitive deficits and accelerated long-term cognitive decline. To date, experimental interventions for delirium have mainly focused on alternative pharmacologic and behavioral strategies in the postoperative period. Read More

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http://dx.doi.org/10.1186/s13063-018-3063-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290549PMC
December 2018
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Vitreous Wiping, a new technique for removal of vitreous cortex remnants during vitrectomy.

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

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http://dx.doi.org/10.1111/aos.13991DOI Listing
December 2018
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Medial collateral ligament laxity in valgus knee deformity before and after medial closing wedge high tibial osteotomy measured with instrumented laxity measurements and patient reported outcome.

J Exp Orthop 2018 Dec 10;5(1):49. Epub 2018 Dec 10.

Department of Orthopaedic Surgery, Maartenskliniek, Nijmegen, The Netherlands.

Introduction: Medial closing wedge high tibial osteotomy (CWHTO) for valgus deformity correction was first described by Coventry whom performed an additional reefing of the medial collateral ligament (MCL) to prevent instability postoperative. In our clinic the additional reefing procedure has never been performed and instability has not been reported routinely by patients. Using instrumented laxity testing, pre- and postoperative valgus and varus knee laxity can be measured objectively. Read More

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https://jeo-esska.springeropen.com/articles/10.1186/s40634-0
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http://dx.doi.org/10.1186/s40634-018-0164-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288099PMC
December 2018
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Association of Preoperative Serum Chloride Levels With Mortality and Morbidity After Noncardiac Surgery: A Retrospective Cohort Study.

Anesth Analg 2018 Dec 7. Epub 2018 Dec 7.

From the Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea.

Background: Postoperative hyperchloremia is known to be related to increases in mortality and morbidity after surgery. However, the relationship between preoperative hyperchloremia and hypochloremia and postoperative mortality and morbidity is not well established. Our aim was to evaluate the relationship between preoperative hyperchloremia or hypochloremia, as assessed using preoperative serum chloride tests, and 90-day mortality and morbidity after noncardiac surgery. Read More

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http://Insights.ovid.com/crossref?an=00000539-900000000-9635
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http://dx.doi.org/10.1213/ANE.0000000000003958DOI Listing
December 2018
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3.472 Impact Factor

High-accuracy Detection of Preoperative Thyroid Nodules Using Combination of BRAF Mutation and TMPRSS4 mRNA Level.

Arch Med Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background: Papillary thyroid cancer (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid cancers. Though the fine needle aspiration biopsy (FNAB) represents as the golden standard for the diagnostics of thyroid nodules, there is a ∼25% risk of indeterminate cytological features. TMPRSS4 is a newly found transmembrane serine protease which was overexpressed in papillary thyroid cancer (PTC). Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.11.003DOI Listing
December 2018
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2.406 Impact Factor

Effect of Radiation on Male Stress Urinary Incontinence and the Role of Urodynamic Assessment.

Urology 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, Division of Pelvic Medicine and Reconstructive Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address:

Objective: To evaluate the effect of radiation on male stress urinary incontinence (SUI) and to assess the relative value of preoperative urodynamic (UDS) testing in radiated vs nonradiated men with SUI.

Methods: A retrospective chart review of all male patients with SUI who underwent UDS testing from 2010 to 2016 was performed. The impact of UDS findings on treatment decision making was assessed. Read More

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http://dx.doi.org/10.1016/j.urology.2018.11.031DOI Listing
November 2018
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Preventing and managing catastrophic bleeding during extracorporeal circulation.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):522-529

Department of Anesthesia, University of Toronto, Toronto, ON, Canada.

The use of extracorporeal circulation for cardiac surgery and extracorporeal life support poses tremendous challenges to the hemostatic equilibrium given its diametric tendency to trigger hyper- and hypocoagulopathy. The necessity of anticoagulant therapy to counteract the hemostatic activation by the extracorporeal circuitry compounded by unfavorable patient and surgical factors significantly increase the risk of catastrophic bleeding in patients who require extracorporeal circulation. Preoperative measures, such as stratification of high-risk bleeding patients, and optimization of the modifiable variables, including anemia and thrombocytopenia, provide a crude estimation of the likelihood and may modify the risk of catastrophic bleeding. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246010PMC
November 2018
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Mesenchymal molecular subtype is an independent predictor of severe postoperative complications after primary debulking surgery for advanced ovarian cancer.

Gynecol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN, United States. Electronic address:

Objective: To evaluate the contribution of molecular subtype to 30-day postoperative complications and 90-day mortality after primary debulking surgery (PDS) in advanced stage high-grade serous ovarian cancer (HGSOC).

Methods: Patients with stages III-IV HGSOC undergoing PDS from 1994 to 2011 with available molecular subtyping were included. Residual disease (RD) status was categorized as 0, 0. Read More

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http://dx.doi.org/10.1016/j.ygyno.2018.11.019DOI Listing
November 2018
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Phenotypical variability in congenital FVII deficiency follows the ISTH-SSC severity classification guidelines: a review with illustrative examples from the clinic.

J Blood Med 2018 19;9:211-218. Epub 2018 Nov 19.

Clinical Development, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA.

Background: One of the most common rare inherited bleeding disorders, congenital factor VII (FVII) deficiency typically has a milder bleeding phenotype than other rare bleeding disorders. Categorizing severity in terms of factor activity associated with hemophilia (severe <1%, moderate 1%-5%, mild 6%-40%) has led to the observation that bleeding phenotype does not follow closely with FVII activity. Over the past decade, large-scale global registries have investigated bleeding phenotype more thoroughly. Read More

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http://dx.doi.org/10.2147/JBM.S157633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250109PMC
November 2018
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Preoperative proteinuria and clinical outcomes in type B aortic dissection after thoracic endovascular aortic repair.

Clin Chem Lab Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Vascular Surgery, Shenzhen Second Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, P.R. China.

Background Proteinuria is a marker of poor outcomes in several diseases; however, few studies have been conducted to explore the prognostic value of proteinuria, assessed by urine dipstick test, for clinical outcomes in patients with type B acute aortic dissection (TBAD) undergoing thoracic endovascular aortic repair (TEVAR). Methods Consecutive patients with TBAD undergoing TEVAR were enrolled from January 2010 to July 2015. Proteinuria was defined as trace or higher, according to the results of urine dipstick testing. Read More

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http://dx.doi.org/10.1515/cclm-2018-0765DOI Listing
November 2018