8,992 results match your criteria Prenatal Nutrition


Making the invisible visible: developing and evaluating an intervention to raise awareness and reduce lead exposure among children and their caregivers in rural Bangladesh.

Environ Res 2021 May 7:111292. Epub 2021 May 7.

Stanford University, Stanford, California, USA. Electronic address:

Lead exposure is harmful at any time in life, but pre-natal and early childhood exposures are particularly detrimental to cognitive development. In Bangladesh, multiple household-level lead exposures pose risks, including turmeric adulterated with lead chromate and food storage in lead-soldered cans. We developed and evaluated an intervention to reduce lead exposure among children and their caregivers in rural Bangladesh. Read More

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Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.

Front Immunol 2021 21;12:650709. Epub 2021 Apr 21.

Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, MD, United States.

Prior to birth, the neonate has limited exposure to pathogens. The transition from the intra-uterine to the postnatal environment initiates a series of complex interactions between the newborn host and a variety of potential pathogens that persist over the first few weeks of life. This transition is particularly complex in the case of the premature and very low birth weight infant, who may be susceptible to many disorders as a result of an immature and underdeveloped immune system. Read More

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Interaction of prenatal bisphenols, maternal nutrients, and toxic metal exposures on neurodevelopment of 2-year-olds in the APrON cohort.

Environ Int 2021 May 4;155:106601. Epub 2021 May 4.

Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Canada; Science for Life Laboratory, Department of Environmental Sciences, Stockholm University, Stockholm, Sweden. Electronic address:

Background: Epidemiological studies suggest that Bisphenol-A (BPA) is a developmental neurotoxicant, but the modifying effects of maternal nutrient status or neurotoxicant metal co-exposures have not been reported. Bisphenol-S (BPS) is being used as a BPA-alternative, but few epidemiological studies have evaluated its effects.

Objectives: To examine if prenatal maternal BPA or BPS exposure are associated with children's neurodevelopment at two years of age while adjusting for effect-measure modification by sex, maternal nutrients, and co-exposure to neurotoxic metals. Read More

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Attention Deficit Hyperactivity Disorder (ADHD) and Associated Factors Among First-Year Elementary School Students.

J Multidiscip Healthc 2021 30;14:997-1005. Epub 2021 Apr 30.

Faculty of Public Health, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.

Purpose: Attention deficit hyperactivity disorder (ADHD) is a mental health disorder commonly in children. This study aimed to examine the prevalence of ADHD and risk factors among first-year pupils in Vietnam's urban city.

Patients And Methods: A cross-sectional study was conducted in four randomly selected primary schools. Read More

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Lessons learned from 25 Years of Research into Long term Consequences of Prenatal Exposure to the Dutch famine 1944-45: The Dutch famine Birth Cohort.

Int J Environ Health Res 2021 May 5:1-15. Epub 2021 May 5.

Department of Epidemiology and Data Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

This paper describes the findings of a historical cohort study of men and women born around the time of the Dutch famine 1944-45. It provided the first direct evidence in humans of the lasting consequences of prenatal undernutrition. The effects of undernutrition depended on its timing during gestation, and the organs and tissues undergoing periods of rapid development at that time. Read More

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Prenatal Ultrasound Suspicion of Cystic Fibrosis in a Multiethnic Population: Is Extensive Genotyping Needed?

Genes (Basel) 2021 Apr 29;12(5). Epub 2021 Apr 29.

Departement de Genetique, DMU Biologie-Pathologie, GH Mondor-Chenevier, AP-HP, F-94010 Creteil, France.

In families without a Cystic Fibrosis (CF) history, fetal ultrasound bowel abnormalities can unexpectedly reveal the disease. Isolated or in association, the signs can be fetal bowel hyperechogenicity, intestinal loop dilatation and non-visualization of fetal gallbladder. In these cases, search for CF transmembrane conductance regulator () gene mutations is part of the recommended diagnostic practices, with a search for frequent mutations according to ethnicity, and, in case of the triad of signs, with an exhaustive study of the gene. Read More

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Sleep disorders during pregnancy and post-partum depression: A systematic review and meta-analysis.

Int J Dev Neurosci 2021 May 3. Epub 2021 May 3.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Postpartum depression (PPD) is one of the most important mental disorders in recent years. However, the effects of prenatal sleep disorders on the development of postpartum depression among pregnant women have not been elucidated. . Read More

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Targeting Treatments to Health Disparities.

Schizophr Bull 2021 May 3. Epub 2021 May 3.

Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO.

These initial data suggest that with prenatal vitamins and choline supplements, we might decrease one risk factor associated with poorer health outcomes disproportionally affecting Black families, ie, preterm birth. Dissemination of this research fulfills the principle of Justice in the Belmont Report, to ensure that participants from different racial, ethnic and socioeconomic groups receive benefits from research directed to their specific problems. Read More

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Prenatal High-Sucrose Diet Induced Vascular Dysfunction in Thoracic Artery of Fetal Offspring.

Mol Nutr Food Res 2021 May 3:e2100072. Epub 2021 May 3.

Department of Obstetrics, Affiliated Hospital of Jining Medical University, Guhuai Road 89, Jining, 272001, China.

Scope: Maternal nutrition during pregnancy is related to intrauterine fetal development. The authors' previous work reports that prenatal high sucrose (HS) diet impaired micro-vascular functions in postnatal offspring. It is unclear whether/how prenatal HS causes vascular injury during fetal life. Read More

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The Association Between Birth Weight and Fat, Sugar, and Vegetable Consumption in a National Sample of U.S. Preschool Age Children.

Matern Child Health J 2021 Apr 30. Epub 2021 Apr 30.

School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Mail Code VPT, Portland, OR, 97239-3098, USA.

Introduction: Adverse prenatal development is a contributor to obesity susceptibility in children. Dietary behavior is one mechanism through which adverse prenatal development may promote obesity, but evidence for the role of prenatal overnutrition in dietary intake in young children is scant.

Methods: We used data from the National Health and Nutrition Examination Survey 2009-2014. Read More

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High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring.

Nutrients 2021 Apr 27;13(5). Epub 2021 Apr 27.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Supplementation with [6S]-5-methyltetrahydrofolic acid (MTHF) is recommended as an alternative to folic acid (FA) in prenatal supplements. This study compared equimolar gestational FA and MTHF diets on energy regulation of female offspring. Wistar rats were fed an AIN-93G diet with recommended (2 mg/kg diet) or 5-fold (5X) intakes of MTHF or FA. Read More

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Nutritional Intervention with Dried Bonito Broth for the Amelioration of Aggressive Behaviors in Children with Prenatal Exposure to Dioxins in Vietnam: A Pilot Study.

Nutrients 2021 Apr 25;13(5). Epub 2021 Apr 25.

System Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.

Dioxins have been suggested to induce inflammation in the intestine and brain and to induce neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), partly due to deficits in parvalbumin-positive neurons in the brain that are sensitive to inflammatory stress. Previously, we reported ADHD traits with increased aggressiveness in children with prenatal exposure to dioxins in Vietnam, whereas dried bonito broth (DBB) has been reported to suppress inflammation and inhibit aggressive behavior in animal and human studies. In the present study, we investigated the association between dioxin exposure and the prevalence of children with highly aggressive behaviors (Study 1), as well as the effects of DBB on the prevalence of children with highly aggressive behaviors (Study 2). Read More

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Effects of a Prenatal Lifestyle Intervention in Routine Care on Maternal Health Behaviour in the First Year Postpartum-Secondary Findings of the Cluster-Randomised GeliS Trial.

Nutrients 2021 Apr 15;13(4). Epub 2021 Apr 15.

Else Kröner-Fresenius-Centre for Nutritional Medicine, Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Georg-Brauchle-Ring 62, 80992 Munich, Germany.

Lifestyle interventions during pregnancy were shown to beneficially influence maternal dietary behaviour and physical activity, but their effect on health behaviour after delivery is unclear. The objective of this secondary analysis was to investigate the sustained effect of a lifestyle intervention in routine care on maternal health behaviour during the first year postpartum. The cluster-randomised controlled "Healthy living in pregnancy" (GeliS) study included 2286 pregnant women. Read More

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Effect of low trans-fatty acid intakes on preeclampsia: A randomized controlled trial.

J Res Med Sci 2020 30;25:112. Epub 2020 Dec 30.

Infertility and Reproductive Health Research Center. Health Research Institute. Babol University of Medical Sciences, Babol, Iran.

Background: Preeclampsia (PE) is a high blood pressure disorder accompanied by proteinuria during pregnancy. It remains unclear whether dietary trans-fatty acid (TFA) can influence PE risk. We examined the effect of low TFA dietary intakes during pregnancy on the risk of PE. Read More

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December 2020

Chronic Stress and Preconception Health Among Latina Women in Metro Atlanta.

Matern Child Health J 2021 Apr 28. Epub 2021 Apr 28.

Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.

Background: Underserved subgroups are less likely to have optimal health prior to pregnancy. We describe preconception health indicators (behavior, pregnancy intention, and obesity) among pregnant Latina women with and without chronic stress in metro Atlanta.

Design: We surveyed 110 pregnant Latina women enrolled in prenatal care at three clinics in Atlanta. Read More

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The Impact of Prenatal Exposure to Ramadan on Child Anthropomorphic Outcomes in Pakistan.

Matern Child Health J 2021 Apr 28. Epub 2021 Apr 28.

Department of Economics, Lahore School of Economics, Intersection Main Blvd DHV Ph VI and Burki Rd., Burki, Lahore, 53200, Pakistan.

Objectives: This study analyzes the intent-to-treat effect of prenatal exposure to Ramadan (the Islamic month of fasting) on outcomes including stunting and underweight for children under age 5 years in Pakistan born between 2003 and 2018.

Methods: The study uses observational data from four rounds of the UN-supported Multiple Indicator Cluster Survey (MICS) data collected on 204,186 children under-5 from Punjab, Pakistan in 2007-2008, 2010-2011, 2013-2014, and 2017-2018. Excluding data on outliers and observations with incomplete data, multivariate logistic regression analysis was conducted on the appended cross-sectional data of 179,943 children under-5 to assess the risk of stunting or underweight according to the month of gestation coinciding with Ramadan. Read More

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Gestational age, birth weight and neurocognitive development in adolescents in Tanzania.

J Pediatr 2021 Apr 23. Epub 2021 Apr 23.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objectives: To investigate the association between gestational age (GA), birthweight, and birthweight adjusted for GA, with domains of neurocognitive development and behavioral problems in adolescents in Tanzania.

Study Design: Data from a long-term follow-up of adolescents aged 11 to 15 years born to women previously enrolled in a randomized controlled trial of prenatal multiple micronutrient supplementation in Dar es Salaam, Tanzania, were used. A battery of neurodevelopmental tests were administered to measure adolescent general intelligence, executive function, and behavioral problems. Read More

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Excess pregnancy weight gain in latinas: Impact on infant's adiposity and growth hormones at birth.

Prev Med Rep 2021 Jun 5;22:101341. Epub 2021 Mar 5.

Department of Pediatrics (GI and Nutrition), University of California, San Francisco, San Francisco 94116, United States.

Excess maternal weight gain during pregnancy has been associated with childhood overweight and obesity both in mothers with and without obesity. Latinx children are at higher risk for earlier obesity compared with other population groups. A cohort of 82 self-identified pregnant Latina women were recruited at the prenatal clinics of Zuckerberg San Francisco General Hospital (ZSFG) prior to delivery during the second and third trimesters of pregnancy in 2011 and 2012. Read More

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The Lutein and Zeaxanthin in Pregnancy (L-ZIP) study-carotenoid supplementation during pregnancy: ocular and systemic effects-study protocol for a randomized controlled trial.

Trials 2021 Apr 22;22(1):300. Epub 2021 Apr 22.

Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah School of Medicine, 65 Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.

Background: Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), collectively called the macular pigment (MP), are dietary carotenoids that preferentially localize in the macula of the human eye. MP protects the macula from photo-oxidative damage and enhances visual function. Inadequate maternal intake of carotenoids, coupled with the placental transfer of maternal carotenoids to support fetal brain and retina development, potentially put mothers at risk of depletion systemically and in their ocular tissues. Read More

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Epigenetics in Necrotizing Enterocolitis.

Curr Pediatr Rev 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, United States.

Epigenetic alterations in our genetic material can lead to heritable changes in the risk, clinical manifestations, course, and the outcomes of many diseases. Understanding these epigenetic mechanisms can help in identifying potential therapeutic targets. This is especially important in necrotizing enterocolitis (NEC), where prenatal as well as postnatal factors impact susceptibility to this devastating condition, but our therapeutic options are limited. Read More

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Exploring the relationship between maternal prenatal stress and brain structure in premature neonates.

PLoS One 2021 21;16(4):e0250413. Epub 2021 Apr 21.

Department of Perinatal Imaging and Health, Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Background: Exposure to maternal stress in utero is associated with a range of adverse outcomes. We previously observed an association between maternal stress and white matter microstructure in a sample of infants born prematurely. In this study, we aimed to investigate the relationship between maternal trait anxiety, stressful life events and brain volumes. Read More

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Does Fetal Growth Adequacy Affect the Nutritional Composition of Mothers' Milk?: A Historical Cohort Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Neonatal Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Objective:  The study aimed to assess the association between intrauterine growth of preterm infants and energy and macronutrient contents in their mothers' milk.

Study Design:  A historical cohort of mothers of preterm infants was assessed according to offspring's intrauterine growth. Fetal growth restriction (FGR) was defined as small-for-gestational age or appropriate for gestational age with fetal growth deceleration. Read More

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The principles of Nurturing Care promote human capital and mitigate adversities from preconception through adolescence.

BMJ Glob Health 2021 04;6(4)

Global TIES for Children, New York University, New York, New York, USA.

A comprehensive evidence-based framework is needed to guide policies and programmes that enable children and adolescents to accrue the human capital required to meet the Sustainable Development Goals (SDGs). This paper proposes a comprehensive, multisectoral, multilevel life-course conceptualisation of human capital development by building on the Nurturing Care Framework (NCF), originally developed for the foundational period of growth and development through the age 3 years. Nurturing care (NC) comprises stable environments that promote children's health and nutrition, protect from threats, and provide opportunities for learning and responsive, emotionally supportive and developmentally enriching relationships. Read More

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Undernutrition - thirty years of the Regional Basic Diet: the legacy of Naíde Teodósio in different fields of knowledge.

Nutr Neurosci 2021 Apr 19:1-22. Epub 2021 Apr 19.

Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Undernutrition is characterized by an imbalance of essential nutrients with an insufficient nutritional intake, a disorder in which the clinical manifestations in most cases are the result of the economic and social context in which the individual lives. In 1990, the study by the medical and humanitarian Naíde Teodósio (1915-2005) and coworkers, which formulated the Regional Basic Diet (RBD) model for inducing undernutrition, was published. This diet model took its origin from the observation of the dietary habits of families that inhabited impoverished areas from the Pernambuco State. Read More

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A cohort study of the association between prenatal arsenic exposure and age at menarche in a rural area, Bangladesh.

Environ Int 2021 Apr 15;154:106562. Epub 2021 Apr 15.

Women's and Children's Health, Uppsala University, Uppsala, Sweden; London School of Hygiene & Tropical Medicine, London, UK.

Background: Millions of individuals worldwide, particularly in Bangladesh, are exposed to arsenic, mainly through drinking water from tube wells. Arsenic is a reproductive toxicant, but there is limited knowledge of whether it influences pubertal development.

Objectives: We evaluated the association between prenatal arsenic exposure and age at menarche. Read More

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Effects of air pollution, land-use type, and maternal mental health on child development in the first two years of life in the Greater Taipei area.

Environ Res 2021 Apr 12;197:111168. Epub 2021 Apr 12.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan. Electronic address:

Introduction: Few studies have investigated the associations of child development with air pollution, land-use type, and maternal mental health simultaneously. Therefore, we evaluated the effect of exposure to air pollutants during several critical periods of life, with adjustment for land-use type and maternal mental status, on child development at 6, 12, and 24 months of age in the Greater Taipei area.

Methods: Participants were selected from an ongoing Taiwanese birth cohort study. Read More

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Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain.

J Perinat Med 2021 Apr 14. Epub 2021 Apr 14.

Analytical and Food Chemistry Department, Nutrition and Bromatology Group, Agri-Food Research and Transfer Cluster (CITACA), Campus da Auga, Faculty of Sciences of the University of Vigo, Ourense, Spain.

Objectives: Antenatal exposure to organic pollutants is a leading public health problem. Meconium is a unique matrix to perform prenatal studies because it enables us to retrospectively evaluate fetal exposure accumulated during the second and third trimester. The aim of the present study was to evaluate associations between organic pollutant levels in meconium and birth weight in NW Spain. Read More

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Gestational Folate and Folic Acid Intake among Women in Canada at Higher Risk of Pre-Eclampsia.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

OMNI Research Group, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects; however, the extent to which recommendations are met through dietary sources and supplements is not clear.

Objectives: Our objective was to evaluate the dietary and supplemental intakes of FA in a Canadian pregnancy cohort and to determine the proportions of pregnant women exceeding the Estimated Average Requirement (EAR) and Tolerable Upper Intake Level (UL).

Methods: FACT (the Folic Acid Clinical Trial) was an international multicenter, randomized, double-blinded, placebo-controlled, phase III trial investigating FA for the prevention of pre-eclampsia in high-risk pregnancies. Read More

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