8,242 results match your criteria Prenatal Nutrition


Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus.

Sci Rep 2020 May 22;10(1):8486. Epub 2020 May 22.

Danone Nutricia Research, Uppsalalaan 12, 3584, CT, Utrecht, The Netherlands.

This study aimed to identify the independent and combined effects of age, BMI at first prenatal visit and GWG on the risk of GDM. A retrospective cohort study of 1,951 pregnant women in Seremban district, Negeri Sembilan, Malaysia. GDM was defined as fasting plasma glucose (FPG) ≥5. Read More

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http://dx.doi.org/10.1038/s41598-020-65251-2DOI Listing

Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and C677T Polymorphisms in Chinese Women.

Diabetes Metab Syndr Obes 2020 5;13:1499-1507. Epub 2020 May 5.

Department of Clinical Laboratory, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing 100730, People's Republic of China.

Purpose: Red blood cell (RBC) folate indicates long-term folate intake, and methylenetetrahydrofolate reductase () gene is the main gene affecting folate status. Increasing evidence suggests an association between gestational diabetes mellitus (GDM) and increased folate levels. Whether RBC folate concentrations in the first trimester of pregnancy or polymorphisms of C677T (rs1801133) affect GDM risk in Chinese pregnant women remains unknown. Read More

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http://dx.doi.org/10.2147/DMSO.S250279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211297PMC

Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses.

Nutrients 2020 May 17;12(5). Epub 2020 May 17.

Department of Science, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy.

Bisphenol A (BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure is widespread and more than 90% of individuals have detectable amounts of the molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal exposure to BPA affects the mevalonate (MVA) pathway in rat brain fetuses, and whether potential effects are sex-dependent. Read More

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http://dx.doi.org/10.3390/nu12051448DOI Listing

STUDY OF AGREEMENT BETWEEN THE ROSSO-MARDONES AND ATALAH SCALES FOR NUTRITIONAL ASSESSMENT IN PREGNANCY. LA ERMITA CLINIC, CARTAGENA, 2017.

Rev Colomb Obstet Ginecol 2020 Mar;71(1):34-41

Médico, Clínica La Ermita de Cartagena, Cartagena, Colombia.

Objective: To assess the degree of agreement between the model for maternal nutritional assessment proposed by Rosso-Mardones and the one proposed by Atalah.

Methods: Diagnostic agreement study. Pregnant women between the ages of 19 and 37 years with a gestational age of 10 or more weeks were incuded; patients with diabetes, thyroid disease, pregnancy-associated hypertension, twin pregnancy, severe fetal malformation, fetal death and hydrops fetalis were excluded. Read More

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http://dx.doi.org/10.18597/rcog.3317DOI Listing

Associations of Serum Selenium Levels in the First Trimester of Pregnancy with the Risk of Gestational Diabetes Mellitus and Preterm Birth: a Preliminary Cohort Study.

Biol Trace Elem Res 2020 May 16. Epub 2020 May 16.

School of Nursing, Peking Union Medical College, Beijing, People's Republic of China.

Women with gestational diabetes mellitus (GDM) may have lower serum selenium levels than healthy controls, which may be associated with preterm birth. We explored the association of serum selenium levels in early pregnancy with the risk of GDM and preterm birth among Chinese women. We included 398 women with a singleton pregnancy, who were followed up prospectively from the first prenatal visit until delivery. Read More

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http://dx.doi.org/10.1007/s12011-020-02191-yDOI Listing

Iodine nutritional status of pregnant women in an urban area of northern Taiwan in 2018.

PLoS One 2020 15;15(5):e0233162. Epub 2020 May 15.

Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Pregnant women are considered as one of the most vulnerable groups for iodine deficiency. The Nutrition and Health Survey in Taiwan 2013 revealed that the median urinary iodine concentration (UIC) of non-pregnant women of child-bearing age of 15-44 years was 124 μg/L, which was adequate in general, but insufficient according to pregnancy criteria. The aim of this study was to determine the iodine nutritional status of pregnant women in an urban area of Northern Taiwan. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233162PLOS

Prenatal effects of maternal nutritional stress and mental health on the fetal movement profile.

Arch Gynecol Obstet 2020 May 14. Epub 2020 May 14.

Department of Mathematical Sciences, Durham University, South Road, Durham, DH1 3LE, UK.

Purpose: Prenatal sub-optimal nutrition and exposure to maternal stress, anxiety and depression in pregnancy have been linked to increased postnatal morbidity and mortality. Fetal growth is most vulnerable to maternal dietary deficiencies, such as those evident in hyperemesis gravidarum (HG), early in pregnancy. The purpose of this pilot study was to examine the effects of HG on fetal movement profiles as a measure of fetal healthy development in the 3rd trimester of pregnancy, and to assess whether nutritional stress on the mother can be evaluated using isotopic analysis of hair. Read More

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http://dx.doi.org/10.1007/s00404-020-05571-wDOI Listing

Treatment of infants with craniofacial malformations.

Arch Dis Child Fetal Neonatal Ed 2020 May 14. Epub 2020 May 14.

Interdisciplinary Centre for Cleft Palate and Craniofacial Malformations, Tuebingen University Hospital, Tuebingen, Germany

Infants with craniofacial malformations (CFMs) are at increased risk of various clinical problems, including respiratory and feeding disorders, the result of which may be long-lasting. An improvement in clinical care can be achieved by prenatal diagnosis and interdisciplinary birth preparation. Feeding problems may particularly be stressful for the family and require a team approach involving nursing staff, speech therapists and nutritional specialists to anticipate, avoid and treat sequelae such as failure to thrive or recurrent aspirations. Read More

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http://dx.doi.org/10.1136/archdischild-2019-317890DOI Listing

Postnatal BPA is associated with increasing executive function difficulties in preschool children.

Pediatr Res 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Early bisphenol exposure may have consequences for executive function development, but less is known about potential sex effects. We hypothesized that early bisphenol A (BPA) and bisphenol S (BPS) exposures would be associated with sex-dependent changes in preschool executive function.

Methods: A subsample of the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort (n = 312) provided maternal second trimester (prenatal) and 3-month postpartum (postnatal) urine samples, from which BPA and BPS concentrations were quantified. Read More

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http://dx.doi.org/10.1038/s41390-020-0922-6DOI Listing

Prenatal exposure to organic pollutants in northwestern Spain using non-invasive matrices (placenta and meconium).

Sci Total Environ 2020 May 5;731:138341. Epub 2020 May 5.

Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Agri-Food Research and Transfer Cluster (CITACA), Campus da Auga, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain. Electronic address:

Human exposure to environmental organic pollutants (OPs) begins in the uterine life period by trans-placental transfer. Epidemiological studies have consistently demonstrated the vulnerability of human fetuses and infants to the effects of OPs because of their rapid growth and organ development, cell differentiation, and immaturity of metabolism. The aim of the present study was to evaluate the prenatal exposure to OPs characterized by different physicochemical properties using non-invasive biological samples (meconium and placenta). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138341DOI Listing

Prenatal Nutrition Containing Bisphenol A Affects Placenta Glucose Transfer: Evidence in Rats and Human Trophoblast.

Nutrients 2020 May 11;12(5). Epub 2020 May 11.

Department of Life Science, University of Siena, 53100 Siena, Italy.

This work aims to clarify the effect of dietary supplementation with Bisphenol A (BPA), a chemical widely present in beverage and food containers, on placental glucose transfer and pregnancy outcome. The study was performed on female Sprague Dawley rats fed with a diet containing BPA (2.5, 25 or 250 μg/Kg/day) for a period of a month (virgin state) plus 20 days during pregnancy. Read More

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http://dx.doi.org/10.3390/nu12051375DOI Listing

Association of Maternal depression with diet: A systematic review.

Asian J Psychiatr 2020 Apr 20;52:102098. Epub 2020 Apr 20.

Institute of Psychology, Health & Society, University of Liverpool, United Kingdom. Electronic address:

This review was conducted to explore the bi-directional association of maternal depression with diet. This link is hypothesized because the mental health of pregnant women may adversely affect their nutritional intake; or inversely, that poor nutritional intake during pregnancy may cause mental health issues. Seven electronic databases were searched to retrieve relevant peer-reviewed articles published during 2000-2018. Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102098DOI Listing

Chinese mothers' intention to vaccinate daughters against human papillomavirus (HPV), and their vaccine preferences: a study in Fujian Province.

Hum Vaccin Immunother 2020 May 13:1-12. Epub 2020 May 13.

Centre for Epidemiology and Evidence-Based Practice, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Little is known regarding Chinese mothers' intention to vaccinate their daughters against human papillomavirus (HPV) since the HPV vaccine was approved for use in China in 2016. The aim was to explore maternal HPV vaccination acceptance, preference for 2-, 4- or 9-valent HPV vaccine and acceptance of domestically manufactured HPV vaccines. Study participants were mothers of primary school children in Southeastern region of Fujian. Read More

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http://dx.doi.org/10.1080/21645515.2020.1756152DOI Listing
May 2020
2.131 Impact Factor

Gut microbiota in early pregnancy among women with Hyperglycaemia vs. Normal blood glucose.

BMC Pregnancy Childbirth 2020 May 11;20(1):284. Epub 2020 May 11.

Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, China.

Background: Recent studies suggest that there is a link between the gut microbiota and glucose metabolism. This study aimed to compare the gut microbiota during early pregnancy of women with hyperglycymia to those with normal blood glucose.

Methods: Gut microbial composition was analysed in 22 women with hyperglycaemia and 28 age-matched healthy controls during their first prenatal visits (< 20 weeks) using high throughput sequencing of the V3-V4 region of the 16S ribosomal RNA gene. Read More

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http://dx.doi.org/10.1186/s12884-020-02961-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216510PMC

Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.

Aging (Albany NY) 2020 May 11;12(9):8434-8458. Epub 2020 May 11.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.

Objective: Many population studies have shown that maternal prenatal nutrition deficiency may increase the risk of neurodevelopmental disorders in their offspring, but its potential transcriptomic effects on brain development are not clear. We aimed to investigate the transcriptional regulatory interactions between genes in particular pathways responding to the prenatal nutritional deficiency and to explore their effects on neurodevelopment and related disorders.

Results: We identified three modules in rat hippocampus responding to maternal prenatal nutritional deficiency and found 15 key genes () related to the rat hippocampus developmental dysregulation, of which and related to autism, and and are related to Alzheimer's disease, and schizophrenia. Read More

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http://dx.doi.org/10.18632/aging.103150DOI Listing

The Effect of the National Birth Defects Intervention Project on the Prevention of Congenital Disabilities among Children in China: A Natural Experiment.

Br J Nutr 2020 May 8:1-18. Epub 2020 May 8.

Institute of Population Research, Peking University, Beijing100871, China.

Most childhood disabilities are caused by congenital factors such as birth defects. The present study aims to evaluate the effect of periconceptional nutrition intervention on the prevention of congenital disability among Chinese children using the National Birth Defects Intervention Project as a natural experiment. We obtained individual-level data from the Second National Sample Survey on Disability, a nationally representative survey, and 110,365 children born between Sep. Read More

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http://dx.doi.org/10.1017/S0007114520001622DOI Listing

Maternal fats and pregnancy complications: Implications for long-term health.

Prostaglandins Leukot Essent Fatty Acids 2020 Jun 21;157:102098. Epub 2020 Apr 21.

Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be) University, Pune Satara Road, Pune, 411043, India. Electronic address:

Pregnancy imposes increased nutritional requirements for the well being of the mother and fetus. Maternal lipid metabolism is critical for fetal development and long-term health of the offspring as it plays a key role in energy storage, tissue growth and cell signaling. Maternal fat composition is considered as a modifiable risk for abnormal lipid metabolism and glucose tolerance during pregnancy. Read More

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http://dx.doi.org/10.1016/j.plefa.2020.102098DOI Listing

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study.

Trials 2020 May 5;21(1):380. Epub 2020 May 5.

Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC, V6T 1Z4, Canada.

Background: North American health authorities recommend 0.4 mg/day folic acid before conception and throughout pregnancy to reduce the risk of neural tube defects. Folic acid is a synthetic form of folate that must be reduced by dihydrofolate reductase and then further metabolized. Read More

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http://dx.doi.org/10.1186/s13063-020-04320-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201521PMC

Are pre-pregnancy weight fluctuations and adherence to prenatal nutrition and exercise recommendations related to excessive gestational weight gain?

J Behav Med 2020 May 2. Epub 2020 May 2.

R. Samuel McLaughlin Foundation-Exercise and Pregnancy Laboratory, University of Western Ontario, London, ON, Canada.

Women who have an overweight or obese pre-pregnancy body mass index (BMI) may be recommended to lose weight before pregnancy, however the association of preconception weight fluctuations and prenatal adherence to nutrition and exercise recommendations with gestational weight gain (GWG) have not been assessed. One hundred women with a pre-pregnancy BMI ≥ 25.0 kg/m who participated in the Nutrition and Exercise Lifestyle Intervention Program (NELIP) were included and stratified as gained weight excessively (n = 47) or not (n = 53) using the 2009 Institute of Medicine GWG guidelines. Read More

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http://dx.doi.org/10.1007/s10865-020-00156-zDOI Listing

The effect of women, infant, and children (WIC) services on birth weight before and during the 2007-2009 great recession in Washington state and Florida: a pooled cross-sectional time series analysis.

BMC Pregnancy Childbirth 2020 Apr 28;20(1):252. Epub 2020 Apr 28.

Department of Child, Family, and Population Health Nursing, School of Nursing, University of Washington, Box # 357263, Seattle, WA, 98195, USA.

Background: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has been shown to have positive effects in promoting healthy birth outcomes in the United States. We explored whether such effects held prior to and during the most recent Great Recession to improve birth outcomes and reduce differences among key socio-demographic groups.

Methods: We used a pooled cross-sectional time series design to study pregnant women and their infants with birth certificate data. Read More

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http://dx.doi.org/10.1186/s12884-020-02937-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189643PMC

The first study of successful pregnancies in Chinese patients with Phenylketonuria.

BMC Pregnancy Childbirth 2020 Apr 28;20(1):253. Epub 2020 Apr 28.

Department of Pediatrics, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang district, Beijing, 100029, China.

Background: Since the inception of newborn screening programs in China in the 1990s, pregnancy among patients with inherited, metabolic disorders has become more common. This study explores the management and outcomes of planned, full-term pregnancies in patients with phenylketonuria (PKU).

Method: Married patients with PKU from 2012 to 2017 were enrolled to receive prenatal counseling and regular health assessments. Read More

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http://dx.doi.org/10.1186/s12884-020-02941-9DOI Listing

Toward a Treatment Normalizing Ovulation Rate in Adolescent Girls With Polycystic Ovary Syndrome.

J Endocr Soc 2020 May 14;4(5):bvaa032. Epub 2020 Mar 14.

Department of Development & Regeneration, University of Leuven, Leuven, Belgium.

Adolescent polycystic ovary syndrome (PCOS) is characterized by androgen excess and oligomenorrhea, and commonly driven by hepato-visceral fat excess ("central obesity") ensuing from a mismatch between prenatal and postnatal nutrition, on a background of genetic susceptibility. There is no approved treatment for adolescent PCOS. We report the pooled results of 2 pilot studies in nonobese girls with PCOS (N = 62, age 15. Read More

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http://dx.doi.org/10.1210/jendso/bvaa032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182125PMC

Changing the Prenatal Care Paradigm to Improve Breastfeeding Outcomes.

Authors:
Diane L Spatz

MCN Am J Matern Child Nurs 2020 May/Jun;45(3):186

Diane L. Spatz is a Professor of Perinatal Nursing & the Helen M. Shearer Professor of Nutrition at the University of Pennsylvania. She holds a joint appointment with the Children's Hospital of Philadelphia (CHOP) where she is a nurse scientist for the lactation program & clinical coordinator of CHOP's Mothers' Milk Bank. Dr. Spatz can be reached via e-mail at

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http://dx.doi.org/10.1097/NMC.0000000000000619DOI Listing

Fine particulate matter exposure and lipid levels among children in Mexico city.

Environ Epidemiol 2020 Apr 9;4(2):e088. Epub 2020 Apr 9.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Studies have identified associations between air pollution and lipid levels in adults, suggesting a mechanism by which air pollution contributes to cardiovascular disease. However, little is known about the association between early life air pollution exposure and lipid levels in children.

Methods: Participants included 465 mother-child pairs from a prospective birth cohort in Mexico City. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147392PMC

The role of the gut microbiome in the development of schizophrenia.

Schizophr Res 2020 Apr 23. Epub 2020 Apr 23.

Department of Psychiatry and Neurobehavioral Science, University College Cork, Ireland; APC Microbiome Ireland, University College Cork, Ireland. Electronic address:

Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence of a complex and dynamic bidirectional interaction of genetic expression and the accumulation of prenatal and postnatal environmental risk factors. The development of the neural circuitry underlying social, cognitive and emotional domains requires precise regulation from molecular signalling pathways, especially during critical periods or "windows", when the brain is particularly sensitive to the influence of environmental input signalling. Many of the brain regions involved, and the molecular substrates sub-serving these domains are responsive to life-long microbiota-gut-brain (MGB) axis signalling. Read More

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http://dx.doi.org/10.1016/j.schres.2020.02.010DOI Listing

Coronavirus disease 2019 (COVID-19) in pregnant women: A report based on 116 cases.

Am J Obstet Gynecol 2020 Apr 23. Epub 2020 Apr 23.

Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China. Electronic address:

Background: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health emergency. Data on the effect of COVID-19 in pregnancy are limited to small case series.

Objectives: To evaluate the clinical characteristics and outcomes in pregnancy and the vertical transmission potential of SARS-CoV-2 infection. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177142PMC

Information needs in pregnant women living in disaster prone area.

Enferm Clin 2020 Mar;30 Suppl 3:80-86

Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Objectives: To describe information needs in pregnant women living in disaster prone area.

Method: A cross-sectional study. Participants were women in the 1st (n=35), the 2nd (n=43), and the 3rd (n=90) trimester of pregnancy who visited public health center for antenatal care from April 2015. Read More

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http://dx.doi.org/10.1016/j.enfcli.2019.12.032DOI Listing

Perfluoroalkyl substances and anthropomorphic measures in children (ages 3-11 years), NHANES 2013-2014.

Environ Res 2020 Apr 15;186:109518. Epub 2020 Apr 15.

Department of Biology, Georgia State University, Atlanta, GA, USA.

Background: Perfluoroalkyl acids (PFAAs) are man-made compounds that are persistent in the environment and highly bioaccumulative in the body. Humans are exposed to a mixture of these substances, and the effects of these mixtures may be different than the effects noted for individual compounds. Prenatal exposure to PFAAs has been associated with decreased birth weight. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109518DOI Listing

Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach.

Environ Int 2020 Apr 17;139:105728. Epub 2020 Apr 17.

Center for Environmental Research and Children's Health, University of California, Berkeley School of Public Health, Berkeley, CA, USA.

Background: Maternal and neonatal thyroid function is critical for growth and neurodevelopment. Exposure to individual per- and polyfluoroalkyl substances (PFAS) can alter circulating thyroid hormone levels, but few studies have investigated effects of combined exposure to multiple PFAS.

Objectives: Estimate associations of exposure to multiple PFAS during early pregnancy with maternal and neonatal thyroid function. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105728DOI Listing

Prenatal infant feeding intentions and actual feeding practices during the first six months postpartum in rural Rwanda: a qualitative, longitudinal cohort study.

Int Breastfeed J 2020 Apr 17;15(1):29. Epub 2020 Apr 17.

Health and Society Chair Group, Wageningen University, Wageningen, The Netherlands.

Background: Exclusive breastfeeding (EBF) is advocated by the WHO for the first 6 months. In Rwanda, the percentage of infants who are exclusively breastfed decreases from 94% among infants aged 0-1 month to 81% among those aged 4-5 months. Little is known about what influences mothers' breastfeeding practices. Read More

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http://dx.doi.org/10.1186/s13006-020-00275-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165388PMC

Household food insecurity associated with gestacional and neonatal outcomes: a systematic review.

BMC Pregnancy Childbirth 2020 Apr 17;20(1):229. Epub 2020 Apr 17.

Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Carlos Chagas Filho Av, 373, CCS. 2 andar. Bloco J. 21941-902 - Ilha do Fundão, Rio de Janeiro, Brazil.

Background: Food insecurity (FI) occurs when people lack secure access to sufficient amounts of safe and nutritious food. FI has been associated with negative effects on human health, including during the prenatal and neonatal periods. The objective of this study is to evaluate the consequences of FI for pregnant women's and newborns' health. Read More

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http://dx.doi.org/10.1186/s12884-020-02917-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164154PMC

Vitamin D in pregnancy: Where we are and where we should go.

J Steroid Biochem Mol Biol 2020 Apr 14;201:105669. Epub 2020 Apr 14.

Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Vitamin D deficiency has been widely reported among pregnant women and infants around the world. Women with low sun exposure, high BMI, low vitamin D intakes and socioeconomic disadvantage with poor quality diets are at greatest risk of vitamin D deficiency, leading to very low serum concentrations of 25-hydroxyvitamin D (25(OH)D) in their offspring and an increased risk of nutritional rickets. Many observational studies, supported by compelling in vitro and in vivo data, have generated evidence suggesting that low vitamin D status in pregnancy may also contribute to the risk of adverse perinatal outcomes including hypertensive disorders (e. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105669DOI Listing

Fetal Alcohol Spectrum Disorders in a Midwestern City: Child Characteristics, Maternal Risk Traits, and Prevalence.

Alcohol Clin Exp Res 2020 Apr 15;44(4):919-938. Epub 2020 Apr 15.

Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota.

Objective: To determine the characteristics of children with fetal alcohol spectrum disorders (FASD) and their mothers in a Midwestern city.

Methods: Case-control samples were drawn from 2 separate first-grade cohorts (combined N = 4,047) in every city school using different methods. In Cohort Sample 1, all consented small children (≤25th centile on height, weight, and/or head circumference) entered the study along with a random sample from all enrolled students. Read More

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http://dx.doi.org/10.1111/acer.14314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166178PMC
April 2020
3.205 Impact Factor

Fetal Alcohol Spectrum Disorders in a Southeastern County of the United States: Child Characteristics and Maternal Risk Traits.

Alcohol Clin Exp Res 2020 Apr 15;44(4):939-959. Epub 2020 Apr 15.

Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota.

Objective: To detail the characteristic traits of children with fetal alcohol spectrum disorders (FASDs) and maternal risk factors in a southeastern U.S. County. Read More

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http://dx.doi.org/10.1111/acer.14313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169982PMC

Fetal Alcohol Spectrum Disorders in a Rocky Mountain Region City: Child Characteristics, Maternal Risk Traits, and Prevalence.

Alcohol Clin Exp Res 2020 Apr 15;44(4):900-918. Epub 2020 Apr 15.

Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota.

Objective: To document prevalence and traits of children with fetal alcohol spectrum disorders (FASD) and maternal risk factors in a Rocky Mountain city.

Methods: Variations on active case ascertainment methods were used in 2 first-grade cohorts in all city schools. The consent rate was 59. Read More

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http://dx.doi.org/10.1111/acer.14315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166196PMC

Prenatal and postnatal determinants in shaping offspring's microbiome in the first 1000 days: study protocol and preliminary results at one month of life.

Ital J Pediatr 2020 Apr 15;46(1):45. Epub 2020 Apr 15.

Dietetics and Clinical Nutrition Laboratory - Department of Public Health, Experimental and Forensic Medicine, University of Pavia, via Bassi 21, 27100, Pavia, Italy.

Background: Fetal programming during in utero life defines the set point of physiological and metabolic responses that lead into adulthood; events happening in "the first 1,000 days" (from conception to 2-years of age), play a role in the development of non-communicable diseases (NCDs). The infant gut microbiome is a highly dynamic organ, which is sensitive to maternal and environmental factors and is one of the elements driving intergenerational NCDs' transmission. The A. Read More

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http://dx.doi.org/10.1186/s13052-020-0794-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158098PMC

Evaluation of a computer-assisted multi-professional intervention to address lifestyle-related risk factors for overweight and obesity in expecting mothers and their infants: protocol for an effectiveness-implementation hybrid study.

BMC Public Health 2020 Apr 15;20(1):482. Epub 2020 Apr 15.

Institute of Health Economics and Clinical Epidemiology, University Hospital of Cologne (IGKE), Cologne, Germany.

Background: The first 1000 days after conception are a critical period to encourage lifestyle changes to reduce the risk of childhood obesity and early programming of chronic diseases. A healthy lifestyle during pregnancy is also crucial to avoid high post-partum weight retention. Currently, lifestyle changes are not consistently discussed during routine health services in Germany. Read More

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http://dx.doi.org/10.1186/s12889-020-8200-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158079PMC

Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.

BMC Pediatr 2020 Apr 15;20(1):164. Epub 2020 Apr 15.

Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, 8th floor, 8330077, Santiago, Chile.

Background: Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring.

Methods: We have designed a birth cohort of 250 families with prenatal recruitment (~ 14 weeks). Read More

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http://dx.doi.org/10.1186/s12887-020-02077-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158062PMC

Risk factors, presentation and outcome of meningomyelocele repair.

Pak J Med Sci 2020 Mar-Apr;36(3):422-425

Dr. Raza Rizvi, MS. Department of Neurosurgery, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Objective: To determine the risk factors, presentation and outcome of meningomyelocele repair.

Methods: We reviewed 150 cases operated for meningomyelocele (MMC) at Jinnah Postgraduate Medical Centre Karachi between May 2015 and May 2018. Data of infants operated for MMC repair was extracted including socioeconomic status, maternal folate intake during pregnancy, head circumference, location and width of the defect, accompanying bladder and limb anomalies and treatments administered. Read More

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http://dx.doi.org/10.12669/pjms.36.3.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150388PMC

[Effects of iron supplement intake on gestational diabetes mellitus in early and middle pregnancy in Chengdu City in 2017].

Wei Sheng Yan Jiu 2020 Mar;49(2):227-232

Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Objective: To explore the effect of iron supplement intake on gestational diabetes mellitus(GDM) in early and middle pregnancy.

Methods: From February to April 2017, a prospective study was conducted among 807 early pregnant women in a prenatal clinic of a maternal and child medical institution in Chengdu City through purposive sampling. Data on maternal demographic characteristics was collected through questionnaire in early pregnancy. Read More

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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2020.02.010DOI Listing

DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS.

Epigenetics 2020 Apr 20:1-17. Epub 2020 Apr 20.

Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.

Clinical and experimental evidences indicate that epigenetic modifications induced by the prenatal environment are related to metabolic and reproductive derangements in polycystic ovary syndrome (PCOS). Alterations in the leptin and adiponectin systems, androgen signalling and antimüllerian hormone (AMH) levels have been observed in PCOS women and in their offspring. Using a targeted Next-Generation Sequencing (NGS), we studied DNA methylation in promoter regions of the leptin (), leptin receptor (), adiponectin (), adiponectin receptor 1 and 2 ( and ), and androgen receptor () genes in 24 sons and daughters of women with PCOS (12 treated with metformin during pregnancy) and 24 children born to non-PCOS women during early infancy (2-3 months of age). Read More

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http://dx.doi.org/10.1080/15592294.2020.1754674DOI Listing

Effects of endocrine disrupting chemicals in pigs.

Environ Pollut 2020 Apr 3;263(Pt B):114505. Epub 2020 Apr 3.

Department of Food and Nutrition, Kookmin University, Seoul, 02707, Republic of Korea. Electronic address:

Endocrine-disrupting chemicals (EDCs) are compounds that interfere with the expression, synthesis, and activity of hormones in organisms. They are released into the environment from flame retardants and products containing plasticizers. Persistent pesticides, such as dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene, also disrupt the endocrine system through interaction with hormone receptors. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114505DOI Listing

Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs.

Front Immunol 2020 19;11:420. Epub 2020 Mar 19.

Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Chorioamnionitis (CA), resulting from intra-amniotic inflammation, is a frequent cause of preterm birth and exposes the immature intestine to bacterial toxins and/or inflammatory mediators before birth via fetal swallowing. This may affect intestinal immune development, interacting with the effects of enteral feeding and gut microbiota colonization just after birth. Using preterm pigs as model for preterm infants, we hypothesized that prenatal exposure to gram-negative endotoxin influences postnatal bacterial colonization and gut immune development. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098537PMC

Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study.

Nutrients 2020 Mar 21;12(3). Epub 2020 Mar 21.

Research Unit for Dietary Studies, The Parker Institute, Bisbebjerg og Frederiksberg Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark.

Background: low vitamin D status in pregnancy can influence the offspring's lung function and contribute to childhood asthma development. The objective of this study was to examine the influence of neonatal vitamin D status on the development of asthma among children age 3-9 years in a large population sample.

Method: in a case-cohort study utilizing a Danish biobank and register data we examined the association between neonatal 25-hydroxyvitamin D (25(OH)D) concentrations and incidence of asthma among children aged 3-9 years. Read More

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http://dx.doi.org/10.3390/nu12030842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146263PMC

Association between mercury in cord serum and sex-specific DNA methylation in cord tissues.

J Dev Orig Health Dis 2020 Apr 3:1-8. Epub 2020 Apr 3.

Department of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

Prenatal exposure to mercury in utero causes abnormal foetal growth and adverse outcomes. DNA methylation is currently considered a possible mechanism through which this occurs. However, few studies have investigated the association between prenatal exposure to mercury and DNA methylation in detail. Read More

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http://dx.doi.org/10.1017/S2040174420000161DOI Listing

Risk factors associated with late-onset neonatal sepsis

Rev Med Inst Mex Seguro Soc 2019 07 1;57(4):226-231. Epub 2019 Jul 1.

Pontificia Universidad Católica del Ecuador, Facultad de Medicina. Quito, Ecuador

Background: Sepsis is one of the main causes of morbidity and mortality in neonates.

Objective: To identify the risk factors for neonatal sepsis in a neonatal unit from March to October, 2016.

Methods: Case-control study. Read More

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Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders.

J Am Coll Nutr 2020 Mar-Apr;39(3):249-260. Epub 2020 Apr 2.

Department of Nutrition, University of California, Davis, Davis, California, USA.

Polyunsaturated fatty acids are vital for optimal fetal neuronal development. The relationship between maternal alcohol consumption and smoking with third trimester plasma fatty acids were examined and their association with Fetal Alcohol Spectrum Disorders (FASD). Moderate to heavy alcohol-using and low/unexposed comparison women were recruited during mid-pregnancy from two prenatal clinics in Ukraine. Read More

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http://dx.doi.org/10.1080/07315724.2020.1737984DOI Listing

PBX1 expression in uterine natural killer cells drives fetal growth.

Sci Transl Med 2020 Apr;12(537)

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.

Abundant decidual natural killer (dNK) cells at the maternal-fetal interface are important during early pregnancy. However, functional subsets of dNK cells remain poorly understood. We describe a CD49aPBX homeobox 1 (PBX1) dNK cell subset that promotes fetal development in humans and mice. Read More

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http://dx.doi.org/10.1126/scitranslmed.aax1798DOI Listing