7,282 results match your criteria Prenatal Diagnosis [Journal]


Primary Fetal Pleural Effusion: Characteristics, Outcomes and the Role of Intervention.

Prenat Diagn 2019 Apr 22. Epub 2019 Apr 22.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Background: We aimed to present the natural history and outcomes of fetal primary pleural effusions (PPE).

Methods: Fetuses with prenatal diagnosis of PPE, delivered between January 2011 and June 2018 were included. Fetal PPE were separated into groups: resolved, stable or progressive. Read More

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http://dx.doi.org/10.1002/pd.5462DOI Listing

Termination of pregnancy for foetal anomalies: parents' preferences for psychosocial care.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Child and Adolescent Psychiatry/Psychology, Unit of Psychosocial Care, Erasmus Medical Center and Sophia Children's Hospital, Rotterdam, The Netherlands.

Objective: To investigate, from the perspective of women and partners, at what stage of a termination of pregnancy (TOP) for foetal anomalies psychosocial care (PSC) is most meaningful, what topics should be discussed, and who should provide PSC.

Method: A cross-sectional retrospective cohort study was conducted with a consecutive series of 76 women and 36 partners, who completed a semi-structured online questionnaire.

Results: Overall, women expressed a greater need for PSC than their partners. Read More

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http://dx.doi.org/10.1002/pd.5464DOI Listing
April 2019
1 Read

Digital vs face-to-face information provision in patient counselling for prenatal screening: a noninferiority randomized controlled trial.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

VU University Amsterdam, Athena Institute for Trans-Disciplinary Research, the Netherlands.

Objective: To evaluate face-to-face information provision in patient counselling for prenatal screening compared to two forms of digital information provision, namely non-interactive instructional video or interactive video.

Method: We performed a prospective, non-inferiority, cluster-randomized controlled trial comparing face-to-face (usual care) to two forms of digital information provision (intervention) in counselling for prenatal screening. This study was performed in the Amsterdam UMC, the Netherlands in 2017, and included women in the first trimester of pregnancy. Read More

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http://dx.doi.org/10.1002/pd.5463DOI Listing

Metabolic Fingerprinting of Chorionic Villous Samples in Normal Pregnancy and Chromosomal Disorders.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico A.Cao, Cagliari, Italy.

Objective: Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Read More

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http://dx.doi.org/10.1002/pd.5461DOI Listing

Neurodevelopmental outcome following prenatal diagnosis of a short corpus callosum.

Prenat Diagn 2019 Apr 13. Epub 2019 Apr 13.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Data regarding the neurodevelopmental outcome of fetal short corpus callosum (CC) diagnosed according to standard reference charts is scarce. The purpose of this study was to assess whether the finding is related to neurodevelopmental delay, and to examine reclassification to normal fetal CC length using CC length/EFW ratio.

Method: Historical prospective cohort study including pregnant women who were referred for fetal neurosonogram due to abnormal CC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pd.5460
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http://dx.doi.org/10.1002/pd.5460DOI Listing
April 2019
1 Read

Fetal Anogenital Distance Using Ultrasound.

Prenat Diagn 2019 Apr 13. Epub 2019 Apr 13.

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Objective: This study measured anogenital distance (AGD) during late second/early third trimester of pregnancy to confirm previous findings that AGD can be measured non-invasively in the fetus using ultrasound, and further showed differences in reference ranges between populations.

Method: 210 singleton pregnancies were recruited at the Rosie Hospital, Cambridge, UK. A 2D ultrasound was performed between 26-30 weeks pregnancy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pd.5459
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http://dx.doi.org/10.1002/pd.5459DOI Listing
April 2019
2 Reads

Potential clinical benefits and limitations of fetal virtopsy using high-field MRI at 7 Tesla versus stereomicroscopic autopsy to assess first trimester fetuses.

Prenat Diagn 2019 Apr 12. Epub 2019 Apr 12.

IMOGEN - Centre of Advanced Research Studies, Emergency County Hospital, Cluj-Napoca, Romania.

Objective: The aim of this study was to establish the diagnostic accuracy of high-field magnetic resonance imaging (MRI) at 7 Tesla (T) compared to that of stereomicroscopic autopsy for assessing first trimester fetuses.

Methods: Nine consecutive cases of first trimester fetuses resulting from spontaneous and therapeutic pregnancy termination were considered. The cases were divided into two groups according to gestational age: the Embryo Group with cases of 9-10 gestational weeks (GW) and the Fetus Group with cases of 13 GW. Read More

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http://dx.doi.org/10.1002/pd.5457DOI Listing
April 2019
1 Read

A multicenter study to predict neonatal survival according to lung-to-head ratio and liver herniation in fetuses with left Congenital Diaphragmatic Hernia (CDH): hidden mortality from the Latin American CDH Study Group Registry.

Prenat Diagn 2019 Apr 13. Epub 2019 Apr 13.

Unidad de Cirugía Fetal, Hospital de Especialidades del Niño y la Mujer, Queretaro, Mexico.

Objective: To evaluate natural history of fetuses congenital diaphragmatic hernia (CDH) prenatally diagnosed in countries where termination of pregnancy is not legally allowed and to predict neonatal survival according to lung area and liver herniation.

Methods: Prospective study including antenatally diagnosed CDH cases managed expectantly during pregnancy in six tertiary Latin American centres. The contribution of the observed/expected lung-to-head ratio (O/E-LHR) and liver herniation in predicting neonatal survival was assessed. Read More

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http://dx.doi.org/10.1002/pd.5458DOI Listing

Myocardial function in fetuses with lower urinary tract obstruction: Is there a cardiac remodeling effect due to renal damage?

Prenat Diagn 2019 Apr 8. Epub 2019 Apr 8.

Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University Hospital UKGM, Justus-Liebig University, Giessen, Germany.

Objectives: Cardiac remodeling due to renal dysfunction may have an impact on myocardial function (MF) of fetuses with lower urinary tract obstruction (LUTO). The aim was to identify possible differences in MF in LUTO fetuses compared to healthy controls and to look for interactions between urine biochemistry and MF indices.

Methods: This is a cohort study consisting of 31 LUTO fetuses and 45 healthy controls. Read More

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http://dx.doi.org/10.1002/pd.5453DOI Listing
April 2019
2 Reads

Chorionic bump at 11 to 13 weeks' gestation: Prevalence and clinical significance.

Authors:
Waldo Sepulveda

Prenat Diagn 2019 Mar 27. Epub 2019 Mar 27.

FETALMED-Maternal-Fetal Diagnostic Center, Fetal Imaging Unit, Santiago, Chile.

Objective: To gather additional data on pregnancy outcome when a chorionic bump is detected at the time of the 11- to 13-week scan.

Methods: The presence of a chorionic bump was prospectively recorded in a database of women presenting for their first-trimester sonographic screening. Clinically relevant information was obtained by reviewing ultrasound reports and medical records or contacting the referring obstetrician or the parents themselves. Read More

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http://dx.doi.org/10.1002/pd.5454DOI Listing
March 2019
3 Reads

Mother-to-child transmission of hepatitis B virus after amniocentesis: A retrospective matched cohort study.

Prenat Diagn 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: The objective of this study is to determine whether amniocentesis increases the risk of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) and evaluate risk factors for MTCT.

Methods: One hundred forty-three hepatitis B surface antigen (HBsAg)-positive women with amniocentesis were enrolled into the amniocentesis group. Six hundred five nonamniocentesis cases were matched with amniocentesis cases based on maternal viral loads, antiviral therapy regimens, and delivery dates. Read More

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http://dx.doi.org/10.1002/pd.5452DOI Listing
March 2019
3 Reads
2.514 Impact Factor

The Solitary Median Maxillary Central Incisor Syndrome (SMMCI): associations, prenatal diagnosis and outcomes.

Prenat Diagn 2019 Mar 22. Epub 2019 Mar 22.

Clinical Genetics Unit. Complejo Hospitalario Universitario Insular Materno Infantil de Canarias, Las Palmas de Gran Canaria, Spain.

Solitary Median Maxillary Central Incisor Syndrome (SMMCI) is a complex disorder consisting of multiple, developmental defects involving midline structures of the head which includes the cranial bones, the maxilla and its container dentition (specifically the central incisor tooth germ), together with other midline structures of the body. SMMCI may appear as an isolated trait or in association with other midline developmental anomalies. We describe the case of a patient with SMMCI. Read More

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http://dx.doi.org/10.1002/pd.5451DOI Listing
March 2019
2 Reads

The continuing saga of patents and non-invasive prenatal testing.

Prenat Diagn 2019 Mar 22. Epub 2019 Mar 22.

School for the Future of Innovation in Society and Consortium for Science, Policy & Outcomes, Arizona State University.

Objective: This paper examines the IP landscape for NIPT in three key regions: USA; Europe, with particular focus on the UK, and Australia.

Method: We explore the patent law issues against the commercial and healthcare environment in these regions, and consider the implications for development and implementation of NIPT.

Results: There are many patents held by many parties internationally, with litigation over these patents ongoing in many countries. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pd.5450
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http://dx.doi.org/10.1002/pd.5450DOI Listing
March 2019
8 Reads

Chromosomal microarray analysis in fetuses with an isolated congenital heart defect: a retrospective, nationwide, multicenter study in France.

Prenat Diagn 2019 Mar 21. Epub 2019 Mar 21.

EA7404-GIG, UFR des sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux.

Objectives: Congenital heart defects (CHDs) may be isolated or associated with other malformations. The use of chromosome microarray (CMA) can increase the genetic diagnostic yield for CHDs by between 4% and 10%. The objective of this study was to evaluate the value of CMA after the prenatal diagnosis of an isolated CHD. Read More

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http://dx.doi.org/10.1002/pd.5449DOI Listing

Is traditional perinatal autopsy needed after detailed fetal ultrasound and post-mortem MRI?

Prenat Diagn 2019 Mar 20. Epub 2019 Mar 20.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Objective: To determine the additional yield from autopsy following prenatal ultrasound and post-mortem magnetic resonance imaging (PMMR) for structural abnormalities.

Method: PMMR was performed on consecutive fetuses over a 6-year period. Prenatal ultrasound and PMMR findings were categorised as concordant, partially concordant or discordant findings. Read More

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http://dx.doi.org/10.1002/pd.5448DOI Listing

The impact of insurance coverage on the prenatal genetic counseling process: An exploration of genetic counselors' experiences with TRICARE.

Prenat Diagn 2019 Mar 18. Epub 2019 Mar 18.

Northwestern University, Graduate Program in Genetic Counseling, Chicago, IL, USA.

The prenatal genetic counseling process may be influenced by the patient's insurance coverage for both prenatal testing and termination. Major commercial insurance providers have different policies. TRICARE is the United States Department of Defense health program for uniformed service members. Read More

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http://dx.doi.org/10.1002/pd.5447DOI Listing
March 2019
3 Reads

Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome.

Prenat Diagn 2019 Mar 13. Epub 2019 Mar 13.

Department "Woman-Mother-Child", Lausanne University Hospital, Materno-Fetal and Obstetrics Research Unit, Lausanne, Switzerland.

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http://doi.wiley.com/10.1002/pd.5446
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http://dx.doi.org/10.1002/pd.5446DOI Listing
March 2019
10 Reads

Evaluation of a new balloon for fetal endoscopic tracheal occlusion in the nonhuman primate model.

Prenat Diagn 2019 Mar 12. Epub 2019 Mar 12.

Department of Maternal Fetal Medicine, Strasbourg University Hospital, Strasbourg, France.

Objective: We developed a new balloon called "Smart-TO," which allows noninvasive and easy unplugging, thanks to a magnetic valve actuated by the magnetic fringe field of a magnetic resonance imaging (MRI) scanner. The objective of this feasibility study was to evaluate the operation of this new balloon in a nonhuman primate model.

Methods: Four pregnant rhesus monkeys underwent fetal endoscopic tracheal occlusion using the "Smart-TO" balloon. Read More

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http://doi.wiley.com/10.1002/pd.5445
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http://dx.doi.org/10.1002/pd.5445DOI Listing
March 2019
8 Reads

Placental vascular recruitment after single intrauterine demise: A newly diagnosed phenomenon unique to monochorionic pregnancies.

Prenat Diagn 2019 Mar 6. Epub 2019 Mar 6.

Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/pd.5444DOI Listing
March 2019
6 Reads

Gene Editing Should Replace Embryo Selection Following PGD.

Prenat Diagn 2019 Mar 4. Epub 2019 Mar 4.

Department Obstetrics and Gynecology, Florida International University Herbert Wertheim College of Medicine, Miami, FL, USA.

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http://doi.wiley.com/10.1002/pd.5442
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http://dx.doi.org/10.1002/pd.5442DOI Listing
March 2019
8 Reads

Noninvasive ablation of rabbit fetal and placental tissue targets in utero using magnetic resonance-guided high-intensity focused ultrasound.

Prenat Diagn 2019 Feb 28. Epub 2019 Feb 28.

Centre for Image Guided Innovation and Therapeutic Intervention, Hospital for Sick Children, Toronto, Canada.

Objective: Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) is a potential noninvasive therapy for fetal conditions. In utero MRgHIFU delivery and proton resonance frequency shift (PRFS) thermometry monitoring will control accuracy of HIFU ablation and confirm in situ tissue heating in a rabbit model.

Methods: High-resolution 3T MR images were acquired in late-gestation rabbits (approximately 30 days, n = 5). Read More

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http://dx.doi.org/10.1002/pd.5443DOI Listing
February 2019
3 Reads

Prenatal imaging throughout gestation in Beckwith-Wiedemann syndrome.

Prenat Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose: Prenatal occurrence and timing of appearance of associated features in Beckwith-Wiedemann syndrome (BWS) are unknown. We reviewed our BWS patients with serial fetal imaging and correlated these with postnatal findings.

Methods: All BWS patients with fetal ultrasound (US) or magnetic resonance imaging (MRI) from 2000 to 2016 were reviewed to determine the presence of polyhydramnios, placentamegaly, macrosomia, macroglossia, retrognathia, omphalocele, visceromegaly, and hemihypertrophy. Read More

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http://dx.doi.org/10.1002/pd.5440DOI Listing
February 2019
2 Reads

Prenatal diagnosis of fragile X syndrome: Small meiotic recombination events at the FMR1 locus.

Prenat Diagn 2019 Feb 18. Epub 2019 Feb 18.

Service de Génétique, CHRU de Tours, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

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http://dx.doi.org/10.1002/pd.5439DOI Listing
February 2019
1 Read

Ensuring high standards for the delivery of NIPT world-wide: Development of an international external quality assessment scheme.

Prenat Diagn 2019 Feb 14. Epub 2019 Feb 14.

CEQAS/GenQA, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Objective: To ensure accurate and appropriate reporting of non-invasive prenatal testing (NIPT) results, the standard of testing should be measured and monitored by participation in external quality assessment (EQA) schemes. The findings from international pilot EQAs for NIPT for the common trisomies are presented.

Methods: In the first pilot, three EQA providers used artificially manufactured reference materials to deliver an EQA for NIPT. Read More

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http://dx.doi.org/10.1002/pd.5438DOI Listing
February 2019
2 Reads

Expanded carrier screening for autosomal recessive conditions in health care: Arguments for a couple-based approach and examination of couples' views.

Prenat Diagn 2019 Feb 12. Epub 2019 Feb 12.

Department of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Expanded carrier screening (ECS) is aimed at detecting carrier states for autosomal recessive (AR) or X-linked conditions in couples from the general population planning a pregnancy. ECS is currently usually offered on an individual basis despite the fact that, for AR conditions, only carrier couples are at risk of affected offspring. In this paper, we present a couple-based ECS test-offer for AR conditions, where results are offered as couple-results only, and describe how couples view such an offer. Read More

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http://dx.doi.org/10.1002/pd.5437DOI Listing
February 2019

Effects of medication intake in early pregnancy on the fetal fraction of cell-free DNA testing.

Prenat Diagn 2019 Feb 10. Epub 2019 Feb 10.

Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.

Objectives: To determine the association between medications intake in early pregnancy and variation in the fetal fraction (FF) in pregnant women undergoing cell-free DNA (cfDNA) testing.

Methods: We performed a retrospective cohort study of women (n = 1051) undergoing cfDNA testing at an academic center. The exposed group included women taking medications (n = 400; 38. Read More

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http://dx.doi.org/10.1002/pd.5436DOI Listing
February 2019

The utilization of prenatal microarray: A survey of current genetic counseling practices and barriers.

Prenat Diagn 2019 Feb 8. Epub 2019 Feb 8.

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas, Houston, Texas.

Objective: We evaluated what prenatal genetic counselor's (GCs) practices, attitudes, and barriers are in regards to prenatal microarray since the publication of the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) guidelines for microarray use.

Methods: This was a survey-based cross-sectional study of English-speaking, board certified or eligible GCs who currently practice prenatal genetic counseling.

Results: Of 192 respondents, 183 (95%) have incorporated chromosome microarray (CMA) into clinical practice, with 64% believing that the benefits of CMA outweigh the harms and 52% agreeing that CMA should be offered to all women regardless of indication. Read More

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http://dx.doi.org/10.1002/pd.5435DOI Listing
February 2019

Effects of platforms, size filter cutoffs, and targeted regions of cytogenomic microarray on detection of copy number variants and uniparental disomy in prenatal diagnosis: Results from 5026 pregnancies.

Prenat Diagn 2019 Feb 8;39(3):137-156. Epub 2019 Feb 8.

Cytogenetics and Genomics, Quest Diagnostics Nichols Institute, San Juan Capistrano, California.

Objective: We evaluated the effects of platforms, size filter cutoffs, and targeted regions of cytogenomic microarray (CMA) on the detection of copy number variants (CNVs) and uniparental disomy (UPD) in prenatal diagnosis.

Methods: Five thousand twenty-six consecutive prenatal specimens (>98% high-risk pregnancy) were studied by high-resolution CMA, with cutoffs of 50 kb for losses and 200 kb for gains in nontargeted regions and 20 kb for losses and 100 kb for gains in targeted regions. We assessed actual detection rates using the current assay as well as hypothetical detection rates using platforms with the same or lower resolution and smaller or larger cutoffs. Read More

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http://dx.doi.org/10.1002/pd.5375DOI Listing
February 2019
1 Read

The uptake of pan-ethnic expanded carrier screening is higher when offered during preconception or early prenatal genetic counseling.

Prenat Diagn 2019 Mar 1;39(4):319-323. Epub 2019 Mar 1.

Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.

Objective: To examine factors that influence uptake of expanded carrier screening (ECS) among women undergoing preconception and prenatal genetic counseling.

Methods: We retrospectively reviewed 500 medical records from women with prenatal or preconception genetic counseling at a prenatal genetic counseling service. We tabulated acceptance of ECS by indication for genetic counseling along with demographic and pregnancy-related factors. Read More

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http://dx.doi.org/10.1002/pd.5434DOI Listing
March 2019
2 Reads

Spina bifida screening in the first trimester using ultrasound biparietal diameter measurement adjusted for crown-rump length or abdominal circumference.

Prenat Diagn 2019 Mar 13;39(4):314-318. Epub 2019 Mar 13.

Reproductive Epidemiology, Leeds Screening Centre, Leeds, UK.

Objective: Compare the performance of first trimester ultrasound biparietal diameter (BPD) screening for open spina bifida (OSB) when BPD is adjusted for crown-rump length (CRL) or abdominal circumference (AC).

Methods: For 63 OSB and 24 265 unaffected pregnancies, BPD was expressed as multiple of the normal median (MoM) based on CRL and on AC, and as the ratio BPD/AC. Screening performance was assessed by the Mahalanobis distance, the observed detection rate with normal fifth and 10th percentile cut-offs and the area under the receiver-operator characteristic curve (AUC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pd.5433
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http://dx.doi.org/10.1002/pd.5433DOI Listing
March 2019
2 Reads

Variants in the 5'-UTR of APELA gene in women with preeclampsia.

Prenat Diagn 2019 Mar 21;39(4):308-313. Epub 2019 Feb 21.

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Objective: To detect APELA gene variants in clinical cases with preeclampsia (PE) and evaluate the influence of the APELA variants in gene expression.

Method: A total of 288 individuals suffering from PE and 384 unaffected individuals were chosen for case-control studies. Genomic DNA was extracted from peripheral blood. Read More

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http://dx.doi.org/10.1002/pd.5431DOI Listing
March 2019
5 Reads
2.514 Impact Factor

Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed CHARGE syndrome individuals.

Prenat Diagn 2019 Feb 4. Epub 2019 Feb 4.

Service de Radiologie, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

"CHARGE syndrome" (CS) is a multifaceted syndrome associated with a poor prognosis. The prenatal diagnosis remains challenging especially as the fetal anomalies that may evoke suspicion of CS are not comprehensively described.

Objective: This study aims to identify the anomalies in MRI with suspected CHARGE syndrome and to propose a possible standardization in the image-based prenatal diagnosis of CS. Read More

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http://dx.doi.org/10.1002/pd.5429DOI Listing
February 2019
1 Read

Cervical lymphatic malformations: Prenatal characteristics and ex utero intrapartum treatment.

Prenat Diagn 2019 Mar;39(4):287-292

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.

Background: The ex utero intrapartum treatment (EXIT) is utilized to transition fetuses with prenatally diagnosed airway obstruction to postnatal life. We describe the unique clinical course, diagnosis, treatment, and outcomes of patients with cervical lymphatic malformation (CLM) managed with EXIT.

Methods: Review of fetuses with diagnosed CLM was delivered by EXIT (2001-2018) in a tertiary referral fetal center. Read More

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http://dx.doi.org/10.1002/pd.5428DOI Listing
March 2019
7 Reads

Maternal complications following open and fetoscopic fetal surgery: A systematic review and meta-analysis.

Prenat Diagn 2019 Mar 27;39(4):251-268. Epub 2019 Feb 27.

Department of Maternal and Fetal Medicine, Institute for Women's Health, University College London, London, UK.

Objective: To establish maternal complication rates for fetoscopic or open fetal surgery.

Methods: We conducted a systematic literature review for studies of fetoscopic or open fetal surgery performed since 1990, recording maternal complications during fetal surgery, the remainder of pregnancy, delivery, and after the index pregnancy.

Results: One hundred sixty-six studies were included, reporting outcomes for open fetal (n = 1193 patients) and fetoscopic surgery (n = 9403 patients). Read More

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http://doi.wiley.com/10.1002/pd.5421
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http://dx.doi.org/10.1002/pd.5421DOI Listing
March 2019
10 Reads

Characteristics of referred patients with twin-twin transfusion syndrome who did not undergo fetal therapy.

Prenat Diagn 2019 Mar 20;39(4):280-286. Epub 2019 Feb 20.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Introduction: Abundant research has reported twin-twin transfusion syndrome (TTTS) outcomes following fetal therapy. Our research describes TTTS patients who did not undergo fetal therapy.

Methods: Records from TTTS pregnancies evaluated at 16 to 26 gestational weeks were reviewed between January 2006 and March 2017. Read More

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http://doi.wiley.com/10.1002/pd.5427
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http://dx.doi.org/10.1002/pd.5427DOI Listing
March 2019
5 Reads

Impact of fetal brain ultrasound tutor smartphone application on normal anatomy learning.

Prenat Diagn 2019 Mar 21;39(4):303-307. Epub 2019 Feb 21.

Department of Medicine and Surgery, Unit of Surgical Sciences, Obstetrics and Gynecology, University of Parma, Parma, Italy.

Objective: The "Fetal Brain Tutor 4us" (FBTApp) is a recently developed application for interactive multiplanar navigation through the normal fetal brain. The purpose of this work was to assess its impact on normal anatomy learning.

Methods: A multiple-choice quiz (MCQ) was administered to first-year resident doctors in Obstetrics and Gynecology in two separate sessions, before and 2 weeks after downloading the FBTApp. Read More

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http://dx.doi.org/10.1002/pd.5426DOI Listing

A survey of current clinical practice of chorionic villus sampling.

Prenat Diagn 2019 Mar 20;39(4):299-302. Epub 2019 Feb 20.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George's University Hospitals NHS Foundation Trust, London, UK.

Objective: The number of invasive procedures (chorionic villus sampling (CVS) or amniocentesis) for fetal testing is decreasing because of the availability of non-invasive prenatal test (NIPT) leading to a centralisation of prenatal diagnostic services to accredited fetal medicine centres. A new survey was conducted 10 years after the previous one to update the current clinical practice among clinicians who regularly perform CVS.

Method: Consultants from 32 centres in the United Kingdom were invited to take part in an online survey evaluating: The total number of CVS procedures carried out in the unit in a typical week, the preferred route (transabdominal [TA] vs transcervical [TC]), technique (use of local anaesthetic [LA] and needle technique). Read More

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http://dx.doi.org/10.1002/pd.5425DOI Listing
March 2019
1 Read

Forty-five consecutive cases of complicated monochorionic multiple pregnancy treated with microwave ablation: A single-center experience.

Prenat Diagn 2019 Mar 19;39(4):293-298. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: To describe our preliminary experience in the application of microwave ablation for selective fetal reduction in complicated monochorionic multiple pregnancies.

Methods: In this prospective study, 45 consecutive complicated monochorionic multiple pregnancies that underwent microwave ablation for selective fetal reduction from July 2015 to February 2017 were analyzed from the first case onward. All patients were managed at the Peking University Third Hospital in Beijing, China. Read More

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http://doi.wiley.com/10.1002/pd.5423
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http://dx.doi.org/10.1002/pd.5423DOI Listing
March 2019
13 Reads

Are all chromosome microarrays the same? What clinicians need to know.

Prenat Diagn 2019 Feb 10;39(3):157-164. Epub 2019 Feb 10.

Hematology Global Marketing, Beckman Coulter Diagnostics, Miami, FL.

Microarray testing is the recommended first-tier diagnostic test for women who undergo invasive prenatal diagnostic procedures. It is well-established that microarray analysis provides information regarding copy number for changes (or copy number variants, CNVs) that may be below the resolution level of standard chromosome analysis, and that such CNVs are not related to maternal age. What may not be appreciated by ordering providers, however, are the technical differences among laboratories with respect to the established laboratory cutoff values for reporting, the definition of targeted versus nontargeted regions, and how these differences may affect the interpretation and reporting of findings which, in turn, affects counseling and possible follow-up testing of family members. Read More

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http://dx.doi.org/10.1002/pd.5422DOI Listing
February 2019
1 Read

Comment on "noninvasive prenatal test for FGFR3-related skeletal dysplasia based on next-generation sequencing and plasma cell-free DNA: Test performance analysis and feasibility exploration".

Prenat Diagn 2019 01 16;39(2):133. Epub 2019 Jan 16.

Perinatal and Maternal Center of Saitama Medical Center, Jichi Medical University, Saitama, Japan.

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http://doi.wiley.com/10.1002/pd.5380
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http://dx.doi.org/10.1002/pd.5380DOI Listing
January 2019
8 Reads
2.514 Impact Factor

Chromosomal microarray analysis in fetuses with congenital anomalies of the kidney and urinary tract: A prospective cohort study and meta-analysis.

Prenat Diagn 2019 Feb 7;39(3):165-174. Epub 2019 Feb 7.

Institute of Embryo-Fetal Original Adult Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To evaluate the usefulness and incremental diagnostic yield of chromosomal microarray analysis (CMA) compared with standard karyotyping in fetuses with congenital anomalies of the kidney and urinary tract (CAKUT).

Methods: A prospective cohort study and systematic review of the literature were conducted. In the prospective cohort study, 123 fetuses with CAKUT, as detected by prenatal ultrasound at our center, were enrolled and evaluated using karyotyping and CMA. Read More

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http://dx.doi.org/10.1002/pd.5420DOI Listing
February 2019
6 Reads
2.514 Impact Factor

Prenatal detection of isolated bilateral hyperechogenic kidneys: Etiologies and outcomes.

Prenat Diagn 2019 Jan 16. Epub 2019 Jan 16.

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Objectives: To delineate the etiology and outcome of prenatally diagnosed isolated bilateral hyperechogenic kidneys (IBHK).

Study Design: Pregnancies with IBHK on prenatal ultrasound identified and followed by us between January 1, 2000 and January 1, 2015 were evaluated regarding the etiology and outcome by evaluation of family history, targeted AR-PKD and AD-PKD DNA analysis, and microarray analysis, according to renal size and amniotic fluid volume.

Results: Of the 52 identified cases, there were 34 cases with enlarged kidneys, 16 with normal size kidneys, and two with small kidneys. Read More

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http://doi.wiley.com/10.1002/pd.5418
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http://dx.doi.org/10.1002/pd.5418DOI Listing
January 2019
11 Reads

The best cutoff value of middle cerebral artery peak systolic velocity for the diagnosis of fetal homozygous alpha thalassemia-1 disease.

Prenat Diagn 2019 Feb 6;39(3):232-237. Epub 2019 Feb 6.

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objective: To determine the best cutoff value of middle cerebral artery peak systolic velocity (MCA-PSV) for the diagnosis of fetuses with homozygous alpha thalassemia-1 disease.

Methods: Pregnancies at risk for fetal homozygous alpha thalassemia-1 disease at 18 to 22 weeks were recruited. MCA-PSV was measured before cordocentesis for hemoglobin typing and complete blood count. Read More

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http://dx.doi.org/10.1002/pd.5419DOI Listing
February 2019
4 Reads

The price of abandoning diagnostic testing for cell free fetal DNA screening.

Prenat Diagn 2019 01 13;39(2):131-132. Epub 2019 Jan 13.

Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1002/pd.5405DOI Listing
January 2019
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Comment on "The price of abandoning diagnostics testing for cell-free fetal DNA screening".

Prenat Diagn 2019 01 13;39(2):130. Epub 2019 Jan 13.

Department of Economics, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/pd.5331DOI Listing
January 2019
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Three-dimensional virtual traveling navigation and three-dimensional printing models of a normal fetal heart using ultrasonography data.

Prenat Diagn 2019 Feb 4;39(3):175-177. Epub 2019 Feb 4.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.

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http://dx.doi.org/10.1002/pd.5417DOI Listing
February 2019
1 Read