933 results match your criteria Premenstrual Dysphoric Disorder


Changes in premenstrual symptoms in women starting or discontinuing use of oral contraceptives.

Gynecol Endocrinol 2019 Jan 22:1-5. Epub 2019 Jan 22.

a Department of Neurobiology, Care Science and Society, Division of Physiotherapy , Karolinska Institutet , Huddinge , Sweden.

It is not clear whether oral contraceptive (OC) treatment affects premenstrual symptoms in women. The aim of the present study was to evaluate changes in premenstrual symptoms (PMS) in women starting to use or discontinuing the use of OCs. Twenty-four healthy women with no previous diagnosis of premenstrual dysphoric disorder were included in this study with a prospective crossover design. Read More

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http://dx.doi.org/10.1080/09513590.2018.1534097DOI Listing
January 2019
1 Read

Neural correlates of depression in women across the reproductive lifespan - An fMRI review.

J Affect Disord 2019 03 27;246:556-570. Epub 2018 Dec 27.

Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, Uniklinik RWTH Aachen University, Pauwelstraße 30, 52074 Aachen, Germany; Institute of Neuroscience and Medicine: JARA-Institute Brain Structure Function Relationship (INM 10), Research Center Jülich, Jülich, Germany.

Introduction: Depressive disorders in women emerge largely during transitions in their reproductive aging cycle, which can be attributed to internal endocrine possesses that affect emotion-associated brain circuits. A review was performed to outline the neural basis in depression during female puberty, premenstrual dysphoric disorder (PMDD), postpartum depression disorder (PPD) and perimenopausal depression disorder.

Methods: For this review, Web of science, Pubmed and PsychInfo databases were searched for functional brain imaging studies addressing reproductive cycle-related mood disorder. Read More

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http://dx.doi.org/10.1016/j.jad.2018.12.133DOI Listing
March 2019
1 Read

Is there a role for reproductive steroids in the etiology and treatment of affective disorders?

Dialogues Clin Neurosci 2018 Sep;20(3):187-196

Behavioral Endocrinology Branch, National Institute of Mental Health, Magnuson Clinical Center, Bethesda, Maryland, USA.

A variety of hormones have been shown to play a role in affective disorders. Reproductive steroids are particularly informative in our efforts to understand the pathophysiology of affective dysregulation for several reasons: i) Reproductive endocrine-related mood disorders (premenstrual dysphoric disorder, perinatal depression, perimenopausal depression) are wonderful clinical models for investigating the mechanisms by which affective state changes occur; ii) Reproductive steroids regulate virtually every system that has been implicated as disturbed in the ontogeny of affective disorders; iii) Despite the absence of a reproductive endocrinopathy a triggering role in the affective disturbance of reproductive mood disorders has been shown clearly for changes in reproductive steroids. The existing data, therefore, support a differential sensitivity to reproductive steroids in reproductive mood disorders such that an abnormal affective state is precipitated by normal changes in reproductive steroids. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296393PMC
September 2018
9 Reads

Early Life Abuse Moderates the Effects of Intranasal Oxytocin on Symptoms of Premenstrual Dysphoric Disorder: Preliminary Evidence From a Placebo-Controlled Trial.

Front Psychiatry 2018 29;9:547. Epub 2018 Nov 29.

Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.

Although intranasal oxytocin (OXT) has been proposed to be a promising treatment for some psychiatric disorders, little research has addressed individual difference factors that may predict response to OXT. One such factor is early life abuse (ELA), which has widespread influences on social-emotional processing and behavior. This single-blind, placebo-controlled crossover trial examined the role of ELA in shaping the effects of intranasal OXT (vs. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282546PMC
November 2018
1 Read

Self-silencing and women's health: A review.

Int J Soc Psychiatry 2018 Dec 5:20764018814271. Epub 2018 Dec 5.

Department of Humanities and Social Sciences, Indian Institute of Technology Kanpur, Kanpur, India.

The connection between gender and health has intrigued health professionals in the last few decades. Silencing-the-self theory has brought a considerable clarity in this matter. After around three decades of the theory, the literature related to the theory has immensely flourished and has covered different branches of psychology. Read More

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http://dx.doi.org/10.1177/0020764018814271DOI Listing
December 2018
14 Reads

[Premenstrual dysphoric disorder is often overlooked].

Ugeskr Laeger 2018 Nov;180(47)

Premenstrual dysphoric disorder (PMDD) is a cluster of severe affective symptoms recurring during the luteal phase of the menstrual cycle, and it affects up to 8% of menstruating women. In Denmark, this disorder is often overlooked. Unlike in the treatment of anxiety and depression, selective serotonin reuptake inhibitors need not be given continuously but can be effective when used only in the luteal phase. Read More

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November 2018
2 Reads

Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules.

Front Psychol 2018 13;9:2065. Epub 2018 Nov 13.

Lab of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China.

To explore the targets, signal regulatory networks and mechanisms involved in Baixiangdan (BXD) capsule regulation of premenstrual dysphoric disorder (PMDD) at the gene transcription level, since the etiology and pathogenesis of PMDD are not well understood. The PMDD rat model was prepared using the resident-intruder paradigm. The rats were tested for aggressive behavior, and those with scores in the lowest 30% were used as controls, while rats with scores in the highest 30% were divided into a PMDD model group, BXD administration group and fluoxetine administration group, which were evaluated with open-field tests and aggressive behavior tests. Read More

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https://www.frontiersin.org/article/10.3389/fpsyg.2018.02065
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http://dx.doi.org/10.3389/fpsyg.2018.02065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242977PMC
November 2018
10 Reads

Premenstrual dysphoric disorder in Arab women: Validation and cultural adaptation of the Arabic version of the premenstrual screening tool.

Women Health 2018 Nov 26:1-15. Epub 2018 Nov 26.

f Department of Psychiatry , Weill Cornell Medicine in Qatar , Doha , Qatar.

Premenstrual dysphoric disorder (PMDD) is not well-studied in Arab populations. The goal of this study was to validate the Arabic version of the Premenstrual Symptoms Screening Tool (PSST) using the DSM diagnosis of PMDD as the gold standard. The PSST was translated and culturally adapted using back translation and the approval of the original author. Read More

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https://www.tandfonline.com/doi/full/10.1080/03630242.2018.1
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http://dx.doi.org/10.1080/03630242.2018.1539433DOI Listing
November 2018
9 Reads

Clusters of premenstrual symptoms in women with PMDD: Appearance, stability and association with impairment.

J Psychosom Res 2018 Dec 13;115:38-43. Epub 2018 Oct 13.

Division of Clinical Psychology and Psychotherapy, Department of Psychology, Philipps-University of Marburg, Marburg, Germany.

Although premenstrual dysphoric disorder (PMDD) is assumed to be a homogenous diagnostic entity, it is hallmarked by highly diverse clinical symptoms. In this study, we investigate symptom clusters in women prospectively diagnosed with severe premenstrual syndrome (PMS) or PMDD using factor analysis; analyze the stability of the structures of different symptom patterns and their association with impairment at work, in recreation, and in relationships. A total of 174 prospective symptom diaries were analyzed with principal axis factoring revealing six clusters named affective dysphoria, somatic dysphoria, irritability, breast/body sensitivity, pain, and eating behavior. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223999183066
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http://dx.doi.org/10.1016/j.jpsychores.2018.10.004DOI Listing
December 2018
6 Reads

Negative cognitive styles as risk factors for the occurrence of PMS and PMDD.

J Reprod Infant Psychol 2018 Nov 23:1-16. Epub 2018 Nov 23.

a Department of Clinical Psychology and Psychopathology , Institute of Psychology, University of Lodz , Łódź , Poland.

Background: The purpose of our study is to verify whether elements of cognitive vulnerability to affective disorders may enhance the occurrence of PMS/PMDD.

Methods: In total, 293 women with regular cycles took part in the study. The subjects were exposed to failure during the follicular phase or luteal phase, as appropriate, and the attributional style of failure, cognitive triad inventory (CTI) and presence of biased information processing were determined. Read More

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http://dx.doi.org/10.1080/02646838.2018.1543943DOI Listing
November 2018
1 Read

Eating disorders in premenstrual dysphoric disorder: a neuroendocrinological pathway to the pathogenesis and treatment of binge eating.

J Eat Disord 2018 25;6:35. Epub 2018 Oct 25.

2Department of Gynecology, Oslo University Hospital, Ullevål Hospital, Oslo, Norway.

Background: This case report details the presentation, treatment and post-operative outcome of an adult female with co-occurring binge eating disorder and premenstrual dysphoric disorder (PMDD).

Case Presentation: The patient, self-presenting for treatment, reported having struggled with severe, debilitating physical and psychological PMDD symptoms for nearly a decade. After having taken part in a number of unsuccessful first- and second line treatments in primary and secondary care, the patient was referred to tertiary care at the Department of Gynecology at Oslo University Hospital in Norway. Read More

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https://jeatdisord.biomedcentral.com/articles/10.1186/s40337
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http://dx.doi.org/10.1186/s40337-018-0222-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201596PMC
October 2018
10 Reads

Epigenetic intersection of BDNF Val66Met genotype with premenstrual dysphoric disorder transcriptome in a cross-species model of estradiol add-back.

Mol Psychiatry 2018 Oct 24. Epub 2018 Oct 24.

Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.

Premenstrual dysphoric disorder (PMDD) affects over 5% of women, with symptoms similar to anxiety and major depression, and is associated with differential sensitivity to circulating ovarian hormones. Little is known about the genetic and epigenetic factors that increase the risk to develop PMDD. We report that 17β-estradiol (E2) affects the behavior and the epigenome in a mouse model carrying a single-nucleotide polymorphism of the brain-derived neurotrophic factor gene (BDNF Val66Met), in a way that recapitulates the hallmarks of PMDD. Read More

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http://dx.doi.org/10.1038/s41380-018-0274-3DOI Listing
October 2018
2 Reads

Sex differences during emotion processing are dependent on the menstrual cycle phase.

Psychoneuroendocrinology 2019 Feb 5;100:85-95. Epub 2018 Oct 5.

Department of Neurology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Sex differences in the neural processing of emotion are of special interest considering that mood and anxiety disorders predominant in females. However, these sex-related differences were typically studied without considering the hormonal status of female subjects, although emotion processing in the brain was shown to differ between phases of the menstrual cycle. In this functional MRI study, we demonstrated the influence of the menstrual cycle phase on sex differences in brain activity and functional connectivity during negative and positive emotions, using two different paradigms: emotion perception and emotion experience. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530173159
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http://dx.doi.org/10.1016/j.psyneuen.2018.09.032DOI Listing
February 2019
8 Reads

Progesterone and plasma metabolites in women with and in those without premenstrual dysphoric disorder.

Depress Anxiety 2018 12 5;35(12):1168-1177. Epub 2018 Sep 5.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: The molecular mechanisms underpinning the progesterone-triggering mood symptoms in women with premenstrual dysphoric disorder (PMDD) are unknown. Cell metabolism is a potential source of variability. Very little is known about the effect of progesterone sensitivity on the metabolome. Read More

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http://dx.doi.org/10.1002/da.22827DOI Listing
December 2018
7 Reads

Acupuncture and acupressure for premenstrual syndrome.

Cochrane Database Syst Rev 2018 08 14;8:CD005290. Epub 2018 Aug 14.

NICM Health Research Institute, Western Sydney University, Building 5, Campbelltown Campus, Penrith, NSW, Australia, 2751.

Background: Acupuncture has a history of traditional use in China for women's health conditions including premenstrual syndrome (PMS), but its effectiveness for this condition remains unclear. This review examined the available evidence supporting the use of acupuncture or acupressure to treat PMS.

Objectives: To evaluate the effectiveness and safety of acupuncture or acupressure for women with PMS or premenstrual dysphoric disorder (PMDD). Read More

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http://dx.doi.org/10.1002/14651858.CD005290.pub2DOI Listing
August 2018
9 Reads

Effect of an educational program on adolescent premenstrual syndrome: lessons from the Great East Japan Earthquake.

Adolesc Health Med Ther 2018 28;9:95-101. Epub 2018 Jun 28.

Division of Women's Health, Research Institute of Traditional Asian Medicine, Kindai University, Osaka, Japan,

Background: Catastrophic disasters such as great earthquakes cause tremendous physical and mental damage. We previously reported that the Great East Japan Earthquake worsened premenstrual symptoms among adolescent girls in the disaster-stricken area.

Objectives: We reanalyzed these data to determine the positive effects of education on premenstrual symptoms. Read More

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http://dx.doi.org/10.2147/AHMT.S169944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029601PMC
June 2018
2 Reads

Prevalence and factors associated with Premenstrual Dysphoric Disorder: A community sample of young adult women.

Psychiatry Res 2018 10 26;268:42-45. Epub 2018 Jun 26.

Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, 373, Gonçalves Chaves, Centro, Pelotas, Rio Grande do Sul, Brazil.

Premenstrual Dysphoric Disorder (PMDD) was recently included in DSM-5 as a full diagnostic category. Few studies have investigated PMDD in a community sample of young adults, especially in Brazil. Thus, the objective of this study was to evaluate the prevalence and the factors associated with PMDD in a community sample of 727 young adult women between the 18 and 24 years of age in southern Brazil. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.06.005DOI Listing
October 2018
9 Reads

Premenstrual dysphoric disorder and its association with complex trauma disorder: Three cases.

Aust N Z J Psychiatry 2018 Sep 18;52(9):904-905. Epub 2018 Jun 18.

Department of Psychiatry, Central Clinical School, Monash University, Monash Alfred Psychiatry Research Centre (MAPrc), Melbourne, VIC, Australia.

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http://dx.doi.org/10.1177/0004867418781488DOI Listing
September 2018
4 Reads

No Menstrual Cyclicity in Mood and Interpersonal Behaviour in Nine Women with Self-Reported Premenstrual Syndrome.

Psychopathology 2018 6;51(4):290-294. Epub 2018 Jun 6.

Department of Psychology, University of Groningen, Groningen, the Netherlands.

Background/aims: Before diagnosing premenstrual dysphoric disorder (PMDD), 2 months of prospective assessment are required to confirm menstrual cyclicity in symptoms. For a diagnosis of premenstrual syndrome (PMS), this is not required. Women with PMDD and PMS often report that their symptoms interfere with mood and social functioning, and are said to show cyclical changes in interpersonal behaviour, but this has not been examined using a prospective approach. Read More

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http://dx.doi.org/10.1159/000489268DOI Listing
October 2018
5 Reads

Perimenstrual exacerbation of symptoms in borderline personality disorder: evidence from multilevel models and the Carolina Premenstrual Assessment Scoring System.

Psychol Med 2018 Sep 28;48(12):2085-2095. Epub 2018 May 28.

The University of North Carolina at Chapel Hill,Chapel Hill, NC,USA.

Background: Individuals with a borderline personality disorder (BPD) suffer from a constellation of rapidly shifting emotional, interpersonal, and behavioral symptoms. The menstrual cycle may contribute to symptom instability among females with this disorder.

Methods: Fifteen healthy, unmedicated females with BPD and without dysmenorrhea reported daily symptoms across 35 days. Read More

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http://dx.doi.org/10.1017/S0033291718001253DOI Listing
September 2018
5 Reads
5.940 Impact Factor

Startling Differences: Using the Acoustic Startle Response to Study Sex Differences and Neurosteroids in Affective Disorders.

Curr Psychiatry Rep 2018 May 18;20(6):40. Epub 2018 May 18.

Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, 3535 Market Street, Philadelphia, PA, 19104, USA.

Purpose Of Review: Neuroactive steroid hormones, such as estradiol and progesterone, likely play a role in the pathophysiology of female-specific psychiatric disorders such as premenstrual dysphoric disorder (PMDD) and postpartum depression and may contribute to the marked sex differences observed in the incidence and presentation of affective disorders. However, few tools are available to study the precise contributions of these neuroactive steroids (NSs). In this review, we propose that the acoustic startle response (ASR), an objective measure of an organism's response to an emotional context or stressor, is sensitive to NSs. Read More

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http://dx.doi.org/10.1007/s11920-018-0906-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050032PMC
May 2018
6 Reads

Premenstrual Syndrome: Existence, Knowledge, and Attitude Among Female University Students in Karachi.

Cureus 2018 Mar 8;10(3):e2290. Epub 2018 Mar 8.

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi.

Objective The aim of this study was to investigate the existence, knowledge, and the attitude of female students towards premenstrual syndrome (PMS). Methods This cross-sectional study was conducted in three universities in Karachi, Pakistan. A total of 448 female students participated in the study. Read More

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https://www.cureus.com/articles/11142-premenstrual-syndrome-
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http://dx.doi.org/10.7759/cureus.2290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940454PMC
March 2018
17 Reads

A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial.

Clin Nutr ESPEN 2018 Apr 9;24:22-30. Epub 2018 Feb 9.

Contract Research Institute daacro, Trier, Germany. Electronic address:

Background & Aims: Many women experience emotional and physical symptoms around the time of ovulation and more so before menstruation interfering with their daily normal life also known as premenstrual syndrome (PMS). Recent observational data suggest that supplementation with Lipogen's phosphatidylserine (PS) and phosphatidic acid (PA) complex (PAS) alleviates these PMS symptoms. The aim of this study was to confirm these observations on the effects of PAS on PMS symptom severity within a controlled clinical trial setting. Read More

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http://dx.doi.org/10.1016/j.clnesp.2018.01.067DOI Listing
April 2018
7 Reads

Semi-Individualized Homeopathy Add-On Versus Usual Care Only for Premenstrual Disorders: A Randomized, Controlled Feasibility Study.

J Altern Complement Med 2018 Jul 22;24(7):684-693. Epub 2018 Mar 22.

1 Department of Health and Nutrition, Louis Bolk Institute , Bunnik, The Netherlands .

Objectives: Premenstrual syndrome and premenstrual dysphoric disorder (PMS/PMDD) bother a substantial number of women. Homeopathy seems a promising treatment, but it needs investigation using reliable study designs. The feasibility of organizing an international randomized pragmatic trial on a homeopathic add-on treatment (usual care [UC] + HT) compared with UC alone was evaluated. Read More

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http://www.liebertpub.com/doi/10.1089/acm.2017.0388
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http://dx.doi.org/10.1089/acm.2017.0388DOI Listing
July 2018
17 Reads

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders.

Complement Med Res 2018 19;25(3):173-182. Epub 2018 Mar 19.

Background/aims: Validation of treatments with individually prescribed homeopathic medicines is a challenging task. A prognostic homeopathic patient questionnaire containing 140 keynote symptoms (highly characteristic of a specific homeopathic medicine) and an electronic algorithm to process the answers were used in 2 clinical studies. The algorithm outcome, based on total symptom scores, indicated 1 of 11 pre-selected homeopathic medicines for women with premenstrual syndrome and premenstrual dysphoric disorder (PMS/PMDD). Read More

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http://dx.doi.org/10.1159/000487318DOI Listing
March 2018
7 Reads

The Menstrual Cycle Influences Emotion but Has Limited Effect on Cognitive Function.

Vitam Horm 2018 19;107:349-376. Epub 2018 Feb 19.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Electronic address:

From a psychological perspective, the menstrual cycle has been a research topic for more than 50 years. The most recent menstrual cycle research has been driven by an increased interest in sex differences in neuroscience, and the urge to understand sex disparities in prevalence, clinical presentation, and treatment response in psychiatric or neurologic disorders. Indeed, the menstrual cycle is an excellent model of ovarian steroid influence on emotion, behavior, and cognition. Read More

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http://dx.doi.org/10.1016/bs.vh.2018.01.016DOI Listing
November 2018
5 Reads

Premenstrual appetite and emotional responses to foods among women with premenstrual dysphoric disorder.

Appetite 2018 Jun 4;125:18-23. Epub 2018 Feb 4.

Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan, ROC; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Department of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. Electronic address:

The aim of the study was to evaluate changes in late-luteal appetite for highly sweet (HS) and highly salty and fatty (HSF) foods in women with premenstrual dysphoric disorder (PMDD). After initial assessment in a psychiatric interview, the premenstrual symptoms screening tool (PSST) was used to identify women with moderate-to-severe premenstrual symptoms. Sixty-seven women with PMDD and 74 healthy controls were evaluated in the early-follicular and late-luteal (pre-menstrual) phases of the menstrual cycle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01956663173102
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http://dx.doi.org/10.1016/j.appet.2018.01.029DOI Listing
June 2018
17 Reads

Female psychopharmacology matters! Towards a sex-specific psychopharmacology.

J Psychopharmacol 2018 Feb 6;32(2):125-133. Epub 2018 Feb 6.

5 Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, USA.

There is increasing recognition that women have a higher prevalence of certain psychiatric illnesses, and a differential treatment response and course of illness compared to men. Additionally, clinicians deal with a number of disorders like premenstrual syndrome, premenstrual dysphoric disorder, and postpartum depression, which affect women specifically and for which treatment and biological pathways are still unclear. In this article we highlight recent research which suggests that different biological mechanisms may underlie sex differences in responsiveness to stress. Read More

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http://dx.doi.org/10.1177/0269881117747578DOI Listing
February 2018
12 Reads

Korean Medication Algorithm for Depressive Disorders 2017: Third Revision.

Clin Psychopharmacol Neurosci 2018 Feb;16(1):67-87

Department of Psychiatry, Chung-Ang University College of Medicine, Seoul, Korea.

Objective: In 2002, the Korean Society for Affective Disorders developed the guidelines for the treatment of major depressive disorder (MDD), and revised it in 2006 and 2012. The third revision of these guidelines was undertaken to reflect advances in the field.

Methods: Using a 44-item questionnaire, an expert consensus was obtained on pharmacological treatment strategies for MDD 1) without or 2) with psychotic features, 3) depression subtypes, 4) maintenance, 5) special populations, 6) the choice of an antidepressant (AD) regarding safety and adverse effects, and 7) non-pharmacological biological therapies. Read More

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http://dx.doi.org/10.9758/cpn.2018.16.1.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810446PMC
February 2018
7 Reads

Brain Structure and Function in Women with Comorbid Bipolar and Premenstrual Dysphoric Disorder.

Front Psychiatry 2017 10;8:301. Epub 2018 Jan 10.

Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Introduction: Hormonal fluctuations associated with female reproductive life events may precipitate or worsen affective episodes in women with bipolar disorder (BD). Previous studies have shown that women with BD report higher rates of premenstrual dysphoric disorder (PMDD) than controls. Further, bipolar women who report premenstrual worsening of mood display a worse course of their bipolar illness. Read More

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http://dx.doi.org/10.3389/fpsyt.2017.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768056PMC
January 2018
13 Reads

Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest: A case report.

J Obstet Gynaecol Res 2018 Apr 23;44(4):797-800. Epub 2018 Jan 23.

Department of Obstetrics and Gynecology, Okayama University Hospital, Okayama, Japan.

Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. Read More

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http://dx.doi.org/10.1111/jog.13578DOI Listing
April 2018
8 Reads

Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity.

Nord J Psychiatry 2018 Apr 7;72(3):221-225. Epub 2018 Jan 7.

a Department of Psychiatry , Ankara Numune Training and Research Hospital , Ankara , Turkey.

Background: Several studies suggest an association between hypovitaminosis D and mood disorders including major depressive disorder, seasonal affective disorder and premenstrual dysphoric disorder. On the other hand, there is not enough study about acute manic episode and hypovitaminosis D. This data insufficient zone led us to study on whether vitamin D deficiency is associated with acute manic episode and has an impact on disease activity Methods: Thirty-one patients with bipolar disorder in remission, 26 patients with acute manic episode and 40 healthy controls with no major psychopathology were recruited in this study. Read More

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http://dx.doi.org/10.1080/08039488.2018.1424238DOI Listing
April 2018
21 Reads

Premenstrual Syndrome: Evidence-based Evaluation and Treatment.

Authors:
Sarah M Appleton

Clin Obstet Gynecol 2018 03;61(1):52-61

University of Colorado, Denver, Colorado.

Premenstrual dysphoric disorder (PMDD) is defined by both physical and psychiatric symptoms that impact a woman significantly during the luteal phase of her menstrual cycle. Diagnostic criteria for PMDD were firmly established in the Diagnostic and Statistical Manual of Mental Disorders V in 2013, but many patients fall short of the diagnosis while still appreciably affected by severe premenstrual symptoms. More recent and robust investigations have evaluated the efficacy of treatment ranging from serotonergic therapy to hormonal treatment as well as lifestyle and herbal remedies. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000339DOI Listing
March 2018
13 Reads

Issues on the diagnosis and etiopathogenesis of mood disorders: reconsidering DSM-5.

J Neural Transm (Vienna) 2018 Feb 23;125(2):211-222. Epub 2017 Dec 23.

Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

The authors present a narrative review from the diagnostic and nosologic viewpoints of mood disorders (bipolar and depressive ones) by revisiting the revision from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision to DSM-5, including the following: the separation of the bipolar and depressive sections; the addition of increased energy and continuation of symptoms to the hypo/manic criteria; the elimination of mixed episodes; the creation of new categories and specifiers ("other specified bipolar and related disorder", "disruptive mood dysregulation disorder", "with anxious distress", "with mixed features", "with peripartum onset"); the categorization of hypo/manic episodes during antidepressant treatment into bipolar disorder; the elimination of the "bereavement exclusion"; the ambiguous separation between bipolar I and II; the insufficient distinction between "other specified bipolar and related disorders" and major depressive disorder; the differentiation regarding borderline personality disorder; agitation; premenstrual dysphoric disorder; and society and psychiatry. Through this analysis, we point out both the achievements and limitations of DSM-5. In addition, to examine the future direction of psychiatry, we introduce our cohort study regarding maternal depression and an outline of the National Institute of Mental Health's Research Domain Criteria project in the US. Read More

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http://dx.doi.org/10.1007/s00702-017-1828-2DOI Listing
February 2018
12 Reads

Premenstrual syndrome and premenstrual dysphoric disorders among Jordanian women.

Perspect Psychiatr Care 2018 Jul 7;54(3):348-353. Epub 2017 Dec 7.

Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman, Jordan.

Purpose: The aim of this study was to investigate the frequency, associated factors, and management approaches of premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS) in Jordanian women.

Design And Methods: Three hundred premenopausal women completed a self-administered questionnaire.

Findings: Moderate-severe PMS was reported by 29% of women, while 14% had PMDD. Read More

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http://dx.doi.org/10.1111/ppc.12252DOI Listing
July 2018
16 Reads
0.712 Impact Factor

Variance in Mood Symptoms Across Menstrual Cycles: Implications for Premenstrual Dysphoric Disorder.

Womens Reprod Health (Phila) 2017 10;4(2):77-88. Epub 2017 Jul 10.

Center for Integrative Study of Animal Behavior, Indiana University, Bloomington, Indiana, USA.

Premenstrual dysphoric disorder (PMDD) remains a controversial diagnosis: Some authors have argued that it pathologizes normal mood changes, and others have questioned the need for daily mood reports across multiple cycles. In the present study, we examined changes in mood among psychologically healthy young participants with regular menstrual cycles. We collected daily reports of negative mood (depression, nervousness, irritability, and fatigue) across two to six consecutive cycles from 27 participants aged 18-35 years, and we used variance decomposition analyses to examine how much of the variance in these daily reports was due to day, cycle, and individual. Read More

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https://www.tandfonline.com/doi/full/10.1080/23293691.2017.1
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http://dx.doi.org/10.1080/23293691.2017.1326248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708589PMC
July 2017
9 Reads

Contraception Update: Oral Contraception.

FP Essent 2017 Nov;462:11-19

Christiana Care Family Medicine Residency Program, 1401 Foulk Road, Suite 100 Wilmington, Delaware 19803.

The oral contraceptive pill (OCP) is the most commonly used form of reversible contraception. The two types of OCPs are combination oral contraceptives (COCs), which contain estrogen and progesterone, and progestin-only pills (POPs). Both have failure rates of approximately 7. Read More

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November 2017
24 Reads

A case of repeated mixed mood episodes with psychotic symptoms associated with the premenstrual period in a patient with polycystic ovarian syndrome.

Gynecol Endocrinol 2018 Jun 22;34(6):467-469. Epub 2017 Nov 22.

a Department of Psychiatry and Behavioral Sciences , University of Texas Health Science Center at Houston , Houston , TX , USA.

Studies have demonstrated that estrogen plays an important role in psychotic and mood disorders in women. Estrogens have a protective effect against the development of these disorders, while hypoestrogenic states may be a risk factor for the development or exacerbation of mental illness. Additionally, women with menstrual cycle abnormalities such as those with a history of anovulation may be more susceptible to monthly estrogen level fluctuation-related mood and psychotic symptoms. Read More

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http://dx.doi.org/10.1080/09513590.2017.1405930DOI Listing
June 2018
4 Reads
1.140 Impact Factor

Estrogen levels, emotion regulation, and emotional symptoms of women with premenstrual dysphoric disorder: The moderating effect of estrogen receptor 1α polymorphism.

Prog Neuropsychopharmacol Biol Psychiatry 2018 03 14;82:216-223. Epub 2017 Nov 14.

Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background: This study evaluated the association between estrogen levels, emotion regulation, depression, anxiety, and stress of women with premenstrual dysphoric disorder (PMDD). We also evaluated the moderating effect of estrogen receptor (ESR) α-Xbal polymorphism on the aforementioned association.

Methods: A total of 100 women were diagnosed with PMDD based on psychiatric interviews and a prospective investigation of 3 menstrual cycles. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2017.11.013DOI Listing
March 2018
22 Reads

Brain activation during emotion regulation in women with premenstrual dysphoric disorder.

Psychol Med 2018 Aug 17;48(11):1795-1802. Epub 2017 Nov 17.

Department of Psychiatry and Biobehavioral Sciences,University of California,Los Angeles,Los Angeles,CA,90024,USA.

Background: Difficulties in regulating emotions are linked to the core symptoms of premenstrual dysphoric disorder (PMDD). We therefore investigated the neural substrates of emotion-regulation problems in women with PMDD.

Methods: On the basis of self-evaluations over 2 months on the Daily Record of Severity of Problems, eligible participants were assigned to two groups: PMDD and control (18 per group). Read More

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https://www.cambridge.org/core/product/identifier/S003329171
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http://dx.doi.org/10.1017/S0033291717003270DOI Listing
August 2018
10 Reads

Premenstrual Dysphoric Disorder: Contemporary Diagnosis and Management.

J Obstet Gynaecol Can 2018 Feb 11;40(2):215-223. Epub 2017 Nov 11.

Department of Psychiatry, Queen's University School of Medicine, Kingston, ON.

Most ovulatory women experience premenstrual symptoms (premenstrual syndrome, molimina) which indicate impending menstruation and are of little clinical relevance because they do not affect quality of life. A few women, however, experience significant physical and/or psychological symptoms before menstruation that, if left untreated, would result in deterioration in functioning and relationships. The precise etiology remains elusive, although new theories are gaining support in pre-clinical and early clinical trials. Read More

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http://dx.doi.org/10.1016/j.jogc.2017.05.018DOI Listing
February 2018
14 Reads

Premenstrual Syndrome Diagnosis: A Comparative Study between the Daily Record of Severity of Problems (DRSP) and the Premenstrual Symptoms Screening Tool (PSST).

Rev Bras Ginecol Obstet 2018 Jan 13;40(1):20-25. Epub 2017 Nov 13.

Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective:  To validate the premenstrual symptoms screening tool (PSST) in relation to the daily record of severity of problems (DRSP) for premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) diagnoses.

Methods:  A cross-sectional study with 127 women (20-45 years) with PMS complaints. The women were evaluated in terms of weight, height and body mass index (BMI). Read More

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http://dx.doi.org/10.1055/s-0037-1608672DOI Listing
January 2018
30 Reads

Methods for coping with premenstrual change: Development and validation of the German Premenstrual Change Coping Inventory.

Women Health 2018 10 4;58(9):1062-1079. Epub 2018 Jan 4.

a Division of Clinical Psychology and Psychotherapy, Department of Psychology , Philipps-University of Marburg , Marburg , Germany.

During the premenstrual phase, psychological and physiological changes can occur, which are associated with different levels of disability. When they appear with Premenstrual Dysphoric Disorder (PMDD), different coping strategies may be used by women to deal with premenstrual changes. Currently no German measure exists for assessing premenstrual symptom-related coping strategies. Read More

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http://dx.doi.org/10.1080/03630242.2017.1377802DOI Listing
October 2018
11 Reads

Reproductive Affective Disorders: a Review of the Genetic Evidence for Premenstrual Dysphoric Disorder and Postpartum Depression.

Curr Psychiatry Rep 2017 Oct 30;19(12):94. Epub 2017 Oct 30.

Department of Psychiatry, Women's Mood Disorders Center, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 305, Baltimore, MD, 21205, USA.

Purpose Of Review: The purpose of this study is to review and summarize the literature exploring the genetic basis for premenstrual dysphoric disorder (PMDD) and postpartum depression (PPD).

Recent Findings: There is more evidence for a genetic basis for PPD than for PMDD, but only when PPD is defined as beginning in the immediate postpartum time period. Familial, genome-wide linkage and association studies, and candidate gene studies, most in the past 10 years, have examined the genetic etiology of reproductive affective disorders, including PMDD and PPD. Read More

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http://dx.doi.org/10.1007/s11920-017-0852-0DOI Listing
October 2017
11 Reads

Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder.

J Neuroendocrinol 2018 Feb;30(2)

Department of Clinical Science, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

Premenstrual dysphoric disorder (PMDD) afflicts 3%-5% of women of childbearing age, and is characterised by recurrent negative mood symptoms (eg, irritability, depression, anxiety and emotional lability) during the luteal phase of the menstrual cycle. The aetiology of PMDD is unknown, although a temporal association with circulating ovarian steroids, in particular progesterone and its metabolite allopregnanolone, has been established during the luteal phase. Allopregnanolone is a positive modulator of the GABA receptor: it is sedative in high concentrations but may precipitate paradoxical adverse effects on mood at levels corresponding to luteal phase concentrations in susceptible women. Read More

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http://dx.doi.org/10.1111/jne.12553DOI Listing
February 2018
15 Reads