1,106 results match your criteria Premenstrual Dysphoric Disorder


Differential grey matter structure in women with premenstrual dysphoric disorder: evidence from brain morphometry and data-driven classification.

Transl Psychiatry 2022 Jun 15;12(1):250. Epub 2022 Jun 15.

Department of Women's and Children's Health, Science for Life Laboratory, Uppsala University, Uppsala, 753 09, Sweden.

Premenstrual dysphoric disorder (PMDD) is a female-specific condition classified in the Diagnostic and Statical Manual-5th edition under depressive disorders. Alterations in grey matter volume, cortical thickness and folding metrics have been associated with a number of mood disorders, though little is known regarding brain morphological alterations in PMDD. Here, women with PMDD and healthy controls underwent magnetic resonance imaging (MRI) during the luteal phase of the menstrual cycle. Read More

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Intermittent selective serotonin reuptake inhibitors for premenstrual syndromes: A systematic review and meta-analysis of randomised trials.

J Psychopharmacol 2022 Jun 10:2698811221099645. Epub 2022 Jun 10.

Pharmacy Department, Maudsley Hospital, South London and Maudsley NHS Foundation Trust, London, UK.

Background: Intermittent (luteal phase) dosing of selective serotonin reuptake inhibitors is one treatment strategy for premenstrual syndromes such as premenstrual dysphoric disorder. This avoids the risk of the antidepressant withdrawal syndrome associated with long-term continuous dosing.

Aims: To compare intermittent dosing to continuous dosing in terms of efficacy and acceptability. Read More

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Premenstrual syndrome predicts alcohol craving in women with substance use disorders.

Women Health 2022 May-Jun;62(5):430-438. Epub 2022 May 31.

Behavioral Science Institute, Radboud University Nijmegen, The Netherlands.

Premenstrual Syndrome (PMS) comprises psychological, somatic, and behavioral symptoms during the luteal phase of almost every menstrual cycle. PMS and premenstrual dysphoric disorder (PMDD) may be associated with substance use. Between 2018 and 2020 we studied the relationship between PMS and substance use within a prospective case-control design comparing a consecutive series of women having a substance use disorder and being treated in an addiction treatment center (ATC group, n = 151)) and one with community dwelling women attending their general practitioner (GP group, n = 101). Read More

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Early and Late Luteal Executive Function, Cognitive and Somatic Symptoms, and Emotional Regulation of Women with Premenstrual Dysphoric Disorder.

J Pers Med 2022 May 18;12(5). Epub 2022 May 18.

Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.

Objective: Cognitive and somatic symptoms were vital factors in developing personalized treatment of depressive disorder. The study aimed to evaluate the following: (1) the cognitive and somatic symptoms of premenstrual dysphoric disorder (PMDD) in the early luteal (EL) and later luteal (LL) phase; and (2) their association with depression and functional impairment of PMDD.

Methods: We prospectively evaluated executive function, emotion regulation, cognitive and somatic symptoms, and depression in the EL and LL phases in women with PMDD. Read More

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Can animal models resemble a premenstrual dysphoric condition?

Front Neuroendocrinol 2022 May 25;66:101007. Epub 2022 May 25.

Departamento de Farmacobiología, CINVESTAV-Sede Sur-Coapa, Mexico City, Mexico. Electronic address:

Around 80% of women worldwide suffer mild Premenstrual Disorders (PMD) during their reproductive life. Up to a quarter are affected by moderate to severe symptoms, and between 3% and 8% experience a severe form. It is classified as premenstrual syndrome (PMS) with predominantly physical symptoms and premenstrual dysphoric disorder (PMDD) with psychiatric symptoms. Read More

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Dimensional (premenstrual symptoms screening tool) categorical (mini diagnostic interview, module U) for assessment of premenstrual disorders.

World J Psychiatry 2022 Apr 19;12(4):603-614. Epub 2022 Apr 19.

Department of Psychiatry, Weill Cornell Medicine - Qatar, Doha 00974, Qatar.

Background: Premenstrual syndrome (PMS) is the constellation of physical and psychological symptoms before menstruation. Premenstrual dysphoric disorder (PMDD) is a severe form of PMS with more depressive and anxiety symptoms. The Mini international neuropsychiatric interview, module U (MINI-U), assesses the diagnostic criteria for probable PMDD. Read More

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Recent advances in understanding/management of premenstrual dysphoric disorder/premenstrual syndrome.

Fac Rev 2022 28;11:11. Epub 2022 Apr 28.

Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS San Matteo Foundation, Pavia, Italy.

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are common disorders of the luteal phase of the menstrual cycle and are characterized by moderate to severe physical, affective, or behavioral symptoms that impair daily activities and quality of life. PMS and PMDD have recently raised great interest in the research community for their considerable global prevalence. The etiology of PMS/PMDD is complex. Read More

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Waist Circumference and Its Association With Premenstrual Food Craving: The PHASE Longitudinal Study.

Front Psychiatry 2022 27;13:784316. Epub 2022 Apr 27.

Department of Pharmacy, University of Illinois, Chicago, IL, United States.

Visceral adiposity is a significant marker of all-cause mortality. Reproductive age women are at a considerable risk for developing visceral adiposity; however, the associated factors are poorly understood. The proposed study evaluated whether food craving experienced during the premenstrual period is associated with waist circumference. Read More

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Premenstrual syndrome and premenstrual dysphoric disorder in adolescents.

Authors:
Khalida Itriyeva

Curr Probl Pediatr Adolesc Health Care 2022 05 6;52(5):101187. Epub 2022 May 6.

Division of Adolescent Medicine, Cohen Children's Medical Center Northwell Health, New Hyde Park, NY, United States; Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, Hempstead, NY, United States. Electronic address:

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) represent two premenstrual disorders characterized by physical and psychological symptoms that occur in the luteal phase of the menstrual cycle, prior to the onset of menses, and have a negative impact on the psychosocial functioning of affected individuals. PMS, more common than PMDD, affects 20-40% of menstruating women, with common symptoms including fatigue, irritability, mood swings, depression, abdominal bloating, breast tenderness, acne, changes in appetite and food cravings. PMDD, affecting a smaller percentage of women, is characterized by more severe symptoms and is listed as a depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Read More

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Cognitive processing of emotional information during menstrual phases in women with and without postpartum depression: differential sensitivity to changes in gonadal steroids.

Arch Womens Ment Health 2022 May 9. Epub 2022 May 9.

Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Gonadal steroids (GSs) have been repeatedly shown to play a central role in the onset of postpartum depression (PPD). The underlying mechanisms, however, are only partially understood. We investigated the relationship between cognitive processing of emotional information and naturally occurring hormonal fluctuations in women with and without previous PPD. Read More

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Roles of childhood maltreatment, personality traits, and life stress in the prediction of severe premenstrual symptoms.

Biopsychosoc Med 2022 Apr 28;16(1):11. Epub 2022 Apr 28.

Department of Psychiatry, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: About 3% to 8% of women of fertile age are thought to have premenstrual dysphoric disorder (PMDD), which is regarded as a serious form of premenstrual syndrome (PMS), although the details of this common condition remain unclear. The aim of this study was to analyze the interrelations of childhood maltreatment, personality traits, and life stress in the etiology of PMS/PMDD.

Methods: A total of 240 adult female volunteers from a community in Japan were investigated, using the following 5 questionnaires: Patient Health Quesstionaire-9, Child Abuse and Trauma Scale, Temperament and Character Inventory (TCI), Life Experiences Survey, and premenstrual dysphoric disorder (PMDD) scale. Read More

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Premenstrual dysphoric disorder: A controversial new diagnosis.

Acta Obstet Gynecol Scand 2022 May;101(5):482-483

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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Grey matter correlates of affective and somatic symptoms of premenstrual dysphoric disorder.

Sci Rep 2022 04 9;12(1):5996. Epub 2022 Apr 9.

Department of Neuroscience, Science for Life Laboratory, Uppsala University, POB 593, 75124, Uppsala, Sweden.

Ovarian hormones fluctuations across the menstrual cycle are experienced by about 58% of women in their fertile age. Maladaptive brain sensitivity to these changes likely leads to the severe psychological, cognitive, and physical symptoms repeatedly experienced by women with Premenstrual Dysphoric Disorder (PMDD) during the late luteal phase of the menstrual cycle. However, the neuroanatomical correlates of these symptoms are unknown. Read More

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A DSM-5-based tool to monitor concurrent mood and premenstrual symptoms: the McMaster Premenstrual and Mood Symptom Scale (MAC-PMSS).

BMC Womens Health 2022 03 30;22(1):96. Epub 2022 Mar 30.

Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, 100 West 5th Street, Suite C124, Hamilton, ON, L8N 3K7, Canada.

Background: Despite high co-morbidity between premenstrual dysphoric disorder and mood disorders, there is a gap of research-based tools to monitor concurrent premenstrual and mood symptoms. In this study, we developed a new DSM-5-based questionnaire to prospectively monitor concurrent premenstrual and mood symptoms.

Methods: Fifty-two females with bipolar or major depressive disorder, ages 16-45, were enrolled in the study. Read More

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Avoidable bilateral salpingo-oophorectomy at hysterectomy: a large retrospective study.

Menopause 2022 05 1;29(5):523-530. Epub 2022 May 1.

Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada.

Objectives: Evaluate the proportion of justified bilateral salpingo-oophorectomy (BSO) at hysterectomy, based on pathologic diagnosis, and determine prevalence of avoidable BSO based on pre- and intraoperative considerations and pathologic diagnosis.

Methods: Retrospective review of hysterectomies at seven Ontario, Canada hospitals from 2016 to 2019. Surgeries completed by oncologists or for invasive placentation were excluded. Read More

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The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective.

Nutrients 2022 Mar 6;14(5). Epub 2022 Mar 6.

Department of Medicine and Medical Specialities, University of Alcala, 28801 Alcalá de Henares, Spain.

Major depressive disorder (MDD) is an incapacitating condition characterized by loss of interest, anhedonia and low mood, which affects almost 4% of people worldwide. With rising prevalence, it is considered a public health issue that affects economic productivity and heavily increases health costs alone or as a comorbidity for other pandemic non-communicable diseases (such as obesity, cardiovascular disease, diabetes, inflammatory bowel diseases, etc.). Read More

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The Concentration of 8-Hydroxy-2'-Deoxyguanosine in Plasma During the Menstrual Cycle in Young Japanese Women.

Womens Health Rep (New Rochelle) 2022 22;3(1):267-273. Epub 2022 Feb 22.

Department of Pharmacy, Hokkaido University of Science, Sapporo, Japan.

The exact pathophysiology of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) is still unknown. This study aimed to investigate the concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in plasma in relation to the menstrual cycle and the severity of premenstrual symptoms in young Japanese women. The study included 21 healthy Japanese women 19-24 years of age. Read More

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February 2022

Association Between Childhood Body Size and Premenstrual Disorders in Young Adulthood.

JAMA Netw Open 2022 03 1;5(3):e221256. Epub 2022 Mar 1.

School of Public Health and Health Sciences, Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst.

Importance: Emerging data suggest that more than two-thirds of premenstrual disorders (PMDs), including premenstrual syndrome and premenstrual dysphoric disorder, have symptom onset during the teen years. Adulthood adiposity has been associated with PMDs; however, the association with childhood and adolescent body size is unknown.

Objective: To examine the association between childhood and adolescent body size and risk of PMDs in young adulthood. Read More

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Academic and Social Impact of Menstrual Disturbances in Female Medical Students: A Systematic Review and Meta-Analysis.

Front Med (Lausanne) 2022 15;9:821908. Epub 2022 Feb 15.

Department of Pathology, St. Matthew's University School of Medicine, Grand Cayman, Cayman Islands.

Background: The stressful academic schedule of medical students poses an obvious challenge to their daily lifestyle. Psychosomatic discomfort poses a significant risk for inaccurate self-medication for ameliorating menstrual complications and feeling better, thus directly impacting personal and academic wellbeing.

Objective: The impact of menstrual disturbances on academic life is not extensively explored. Read More

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February 2022

Investigating biological rhythms disruptions across the menstrual cycle in women with comorbid bipolar disorder and premenstrual dysphoric disorder.

Arch Womens Ment Health 2022 04 28;25(2):345-353. Epub 2022 Feb 28.

Mood Disorders Program, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

We investigated whether women diagnosed with comorbid bipolar disorder (BD) and premenstrual dysphoric disorder (PMDD) experience higher disruptions in biological rhythms in two independent study samples. The first study has a population-based sample of 727 women, including 104 women with PMDD only, 43 women with BD only, 24 women with comorbid PMDD and BD, and 556 women without BD or PMDD (controls). Biological rhythm disruptions were cross-sectionally evaluated using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Read More

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Prevalence of Premenstrual Syndrome and Associated Factors Among Academics of a University in Midwest Brazil.

Rev Bras Ginecol Obstet 2022 Feb 25;44(2):133-141. Epub 2022 Feb 25.

Programa de Pós-Graduação em Saúde Coletiva, Universidade do Vale do Rio dos Sinos, São Leopoldo, RS, Brazil.

Objective:  To investigate the prevalence of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in university students, the factors associated with PMS, the most prevalent symptoms, and the interference of symptoms in academic, family, social, and work activities.

Methods:  This cross-sectional study included 1,115 university students aged ≥ 18 years from the University of Rio Verde, Goiás. Premenstrual syndrome and PMDD were identified using the Premenstrual Symptoms Screening Tool. Read More

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February 2022

White matter microstructure and volume correlates of premenstrual dysphoric disorder.

J Psychiatry Neurosci 2022 Jan-Feb;47(1):E67-E76. Epub 2022 Feb 23.

From the Department of Neuroscience, Science for Life Laboratory, Uppsala University, Sweden (Gu, Dubol, Comasco); the Department of Clinical Sciences, Umeå University, Umeå, Sweden (Stiernman, Bixo); the Department of Surgical Sciences, Neuroradiology, Uppsala University, Sweden (Wikström); the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Hahn, Lanzenberger); the Department of Psychiatry, University of Colorado School of Medicine, USA (Epperson); the Department of Women's and Children's Health, Uppsala University, Sweden (Sundström-Poromaa)

Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity. Read More

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Association between adverse childhood experiences and premenstrual disorders: a cross-sectional analysis of 11,973 women.

BMC Med 2022 02 21;20(1):60. Epub 2022 Feb 21.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

Background: Childhood abuse and neglect have been associated with premenstrual disorders (PMDs), including premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). However, the associations of other adverse childhood experiences (ACEs) and the cumulative number of ACEs with PMDs remain to be explored.

Methods: To evaluate the associations of the cumulative number and types of ACEs with PMDs, we conducted a cross-sectional analysis with a subsample of menstruating women within the Stress-And-Gene-Analysis (SAGA) cohort, assessed for PMDs and ACEs (N=11,973). Read More

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February 2022

Effects of Auriculotherapy on treatment of women with premenstrual syndrome symptoms: A randomized, placebo-controlled clinical trial.

Complement Ther Med 2022 Jun 12;66:102816. Epub 2022 Feb 12.

Prevention and Rehabilitation in Physical Therapy Department, Federal University of Parana, Curitiba, Brazil. Electronic address:

Objective: This study aimed to investigate the effect of auriculotherapy on the intensity of physical and mood Premenstrual syndrome (PMS) symptoms.

Design: Single-blind randomized, placebo-controlled clinical trial.

Setting: Federal University of Parana, Curitiba, Brazil. Read More

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Evaluation of a natural S-equol supplement in treating premenstrual symptoms and the effect of the gut microbiota: An open-label pilot study.

Neuropsychopharmacol Rep 2022 Jun 6;42(2):127-134. Epub 2022 Feb 6.

Clinical Research Center, Kindai University Hospital, Osaka-Sayama, Japan.

Aim: Premenstrual syndrome causes disturbances in many women's daily activities. Isoflavones might cause changes in the estrogen cycle by their selective estrogen receptor modulator-like activities. Equol, which is a metabolite of a soy isoflavone, has greater biological activity than other soy isoflavones. Read More

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Global and regional prevalence and burden for premenstrual syndrome and premenstrual dysphoric disorder: A study protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2022 Jan;101(1):e28528

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.

Introduction: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are becoming common mental diseases in women impairing daily functioning. Estimation of the epidemiological burden of PMS/PMDD can serve as scientific basis for prevention and management of premenstrual disorders. Herein, we firstly provide a protocol to perform estimation on the prevalence and risk factors for PMS/PMDD in the general population globally and regionally. Read More

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January 2022

The prevalence of early life trauma in premenstrual dysphoric disorder (PMDD).

Psychiatry Res 2022 02 2;308:114381. Epub 2022 Jan 2.

Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, VC, Australia.

Early life trauma is a risk factor for many mental disorders; however, there is a lack of research exploring early life trauma in Premenstrual Dysphoric Disorder (PMDD), a debilitating form of Premenstrual Syndrome (PMS). This descriptive study aimed to determine the prevalence of early life trauma in women with PMDD and characterise type and age of trauma experience. Data for 100 women diagnosed with PMDD was extracted from the Monash Alfred Women's Mental Health Clinic Database. Read More

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February 2022