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    6163 results match your criteria Premature Ventricular Contraction

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    Relation Between Ventricular Premature Complexes and Incident Heart Failure.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California. Electronic address:
    Ventricular premature complexes (VPCs) may represent a reversible cause of heart failure (HF); however, the type of patients most prone remains unknown. This study leverages a large population-based database to examine interactions that might prove clinically useful in risk-stratifying patients with VPCs. We used the California Healthcare Cost and Utilization Project to identify patients with VPCs and incident systolic HF from January 1, 2005, to December 31, 2009. Read More

    Risk factor algorithm used to predict frequent premature ventricular contraction-induced cardiomyopathy.
    Int J Cardiol 2017 Feb 3. Epub 2017 Feb 3.
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea. Electronic address:
    Background: Premature ventricular contraction (PVC) QRS duration (QRSd) and high PVCs burden are known as a risk factor of PVC-induced cardiomyopathy (CMP). The aim of this study is to find useful algorithm to predict PVC-induced CMP.

    Methods: 180 patients (99 males, 51±14years) with frequent PVCs (>10%/24h), who underwent successful PVC ablation, were studied. Read More

    Incidence of Idiopathic Ventricular Arrhythmias: A Population-Based Study.
    Circ Arrhythm Electrophysiol 2017 Feb;10(2)
    From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
    Background: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown.

    Methods And Results: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. Read More

    [Primary Lung Cancer Associated with Dilated Phase of Hypertrophic Cardiomyopathy;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):147-150
    Department of General, Endoscopic, Cardiovascular, Thoracic and Breast Surgery, Tsugaru General Hospital, Goshogawara, Japan.
    A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3. Read More

    Premature Ventricular Complex Ablation in Structural Heart Disease.
    Card Electrophysiol Clin 2017 Mar 4;9(1):133-140. Epub 2017 Jan 4.
    Division of Electrophysiology, Department of Internal Medicine, University of Michigan Health System, CVC, SPC 5853, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5853, USA.
    Frequent premature ventricular complexes (PVCs) in patients with underlying structural heart disease, particular after myocardial infarction, can predict increased mortality. Use of antiarrhythmic medications to suppress PVCs in this setting can result in a further increase in mortality. High PVC burdens in patients with structural heart disease can cause or worsen cardiomyopathy and successful elimination of PVCs with catheter ablation can improve or, in some cases normalize, cardiac function. Read More

    Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.
    Nat Commun 2017 Jan 27;8:14155. Epub 2017 Jan 27.
    Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
    The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. Read More

    Prognostic significance of exercise-induced premature ventricular complexes: a systematic review and meta-analysis of observational studies.
    Heart Asia 2017 4;9(1):14-24. Epub 2017 Jan 4.
    University College London , London , UK.
    Background: Exercise-induced premature ventricular complexes (EI-PVCs) are common during exercise stress tests. Their optimal management and prognostic significance remain uncertain.

    Aim: To perform meta-analysis of observational studies on the prognostic significance of EI-PVCs. Read More

    Brain Emboli After Left Ventricular Endocardial Ablation.
    Circulation 2017 Jan 24. Epub 2017 Jan 24.
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, CA
    Background: -Catheter ablation for ventricular tachycardia (VT) and premature ventricular complexes (PVCs) is common. Catheter ablation of atrial fibrillation is associated with a risk of cerebral emboli attributed to cardioversions and numerous ablation lesions in the low-flow left atrium, but cerebral embolic risk in ventricular ablation has not been evaluated.

    Methods: -We enrolled 18 consecutive patients meeting study criteria scheduled for VT or PVC ablation over a 9-month period. Read More

    Anatomical Consideration in Catheter Ablation of Idiopathic Ventricular Arrhythmias.
    Arrhythm Electrophysiol Rev 2016 ;5(3):203-209
    Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, US.
    Idiopathic ventricular arrhythmias (VAs) are ventricular tachycardias (VTs) or premature ventricular contractions (PVCs) with a mechanism that is not related to myocardial scar. The sites of successful catheter ablation of idiopathic VA origins have been progressively elucidated and include both the endocardium and, less commonly, the epicardium. Idiopathic VAs usually originate from specific anatomical structures such as the ventricular outflow tracts, aortic root, atrioventricular (AV) annuli, papillary muscles, Purkinje network and so on, and exhibit characteristic electrocardiograms based on their anatomical background. Read More

    Non-Invasive Personalisation of a Cardiac Electrophysiology Model from Body Surface Potential Mapping.
    IEEE Trans Biomed Eng 2016 Nov 16. Epub 2016 Nov 16.
    Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. Read More

    Heterogeneous distribution of substrates between the endocardium and epicardium promotes ventricular fibrillation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
    Europace 2017 Jan 12. Epub 2017 Jan 12.
    Faculty of Medicine, Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University.
    Aims: Whether the distribution of scar in arrhythmogenic right ventricular cardiomyopathy (ARVC) plays a role in predicting different types of ventricular arrhythmias is unknown. This study aimed to investigate the prognostic value of scar distribution in patients with ARVC.

    Methods And Results: We studied 80 consecutive ARVC patients (46 men, mean age 47 ± 15 years) who underwent an electrophysiological study with ablation. Read More

    An observational study on the effect of premature ventricular complex burden on long-term outcome.
    Medicine (Baltimore) 2017 Jan;96(1):e5476
    aDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital bDepartment of Medicine, Division of Cardiology, National Yang-Ming University School of Medicine, Taipei cDepartment of Medicine, Taipei Veterans General Hospital, Yuanshan Branch, Yilan dInstitute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University, Taipei eDivision of Cardiology, National Yang-Ming University Hospital, Yi-Lan, Taiwan.
    The long-term clinical impact of premature ventricular complexes (PVCs) on mortality and morbidity has not been fully studied. This study aimed to investigate the association between the burden of PVCs and adverse clinical outcome.A total of 5778 subjects, who were pacemaker-free and ventricular tachycardia-free at baseline, received 24-hour electrocardiography monitoring between January 1, 2002 and December 31, 2004. Read More

    A novel method to enhance phenotype, epicardial functional substrates, and ventricular tachyarrhythmias in Brugada syndrome.
    Heart Rhythm 2017 Jan 6. Epub 2017 Jan 6.
    Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
    Background: Fever is associated with the manifestation of Brugada phenotype and ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with Brugada syndrome (BrS). The thermal effect on the pathogenesis of functional substrates in BrS remains unknown.

    Objective: This study aimed to elucidate the thermal effect on BrS phenotype, VT/VF, and electrophysiological characteristics of epicardial functional substrates in BrS. Read More

    Providing an Efficient Algorithm for Finding R Peaks in ECG Signals and Detecting Ventricular Abnormalities With Morphological Features.
    J Med Signals Sens 2016 Oct-Dec;6(4):218-223
    Department of Engineering, Shahed University, Tehran, Iran.
    Ventricular arrhythmias are one of the most important causes of annual deaths in the world, which may lead to sudden cardiac deaths. Accurate and early diagnosis of ventricular arrhythmias in heart diseases is essential for preventing mortality in cardiac patients. Ventricular activity on the electrocardiogram (ECG) signal is in the interval from the beginning of QRS complex to T wave end. Read More

    Elimination of Ventricular Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia by Targeting "Catecholamine-Sensitive Area": A Dominant-Subordinate Relationship between Origin Sites of Bidirectional Ventricular Premature Contractions.
    Pacing Clin Electrophysiol 2016 Dec 24. Epub 2016 Dec 24.
    Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
    We report on a patient diagnosed with catechoaminergic polymorphic ventricular tachycardia (CPVT) who underwent catheter ablation of ventricular premature contractions (VPCs) induced by epinephrine. VPCs were classified roughly into three types. Type 1 and Type 2 VPCs (right bundle branch block [RBBB] configuration and inferior axis) were eliminated by radiofrequency applications at the left aortic sinus of Valsalva and the anterolateral papillary muscle (APM), respectively. Read More

    Localization of premature ventricular contractions from the papillary muscles using the standard 12-lead electrocardiogram: a feasibility study using a novel cardiac isochrone positioning system.
    Europace 2016 Dec;18(suppl 4):iv16-iv22
    UCLA Cardiac Arrhythmia Center, UCLA Heath System, David Geffen School of Medicine at UCLA, Suite 660 Los Angeles, CA 90095, USA.
    Aims: The precise localization of the site of origin of a premature ventricular contraction (PVC) prior to ablation can facilitate the planning and execution of the electrophysiological procedure. In clinical practice, the targeted ablation site is estimated from the standard 12-lead ECG. The accuracy of this qualitative estimation has limitations, particularly in the localization of PVCs originating from the papillary muscles. Read More

    Catheter ablation of ventricular ectopy with para-hisian origin: importance of mapping both sides of the interventricular septum and understanding when to stop ablating.
    Clin Case Rep 2016 Dec 13;4(12):1195-1200. Epub 2016 Nov 13.
    Department of Arrhythmia and ElectrophysiologyDivision of CardiologyZentralklinik Bad BerkaBad BerkaGermany; Otto-von-Guericke University School of MedicineMagdeburgGermany.
    Catheter ablation of para-Hisian premature ventricular contractions (PVCs) still represents a challenge and is a compromise between success and inadvertent AV block. We describe a possible strategy to address PVCs from this location with high-amplitude His-bundle potentials at the site of earliest activation. Read More

    Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
    Circ Arrhythm Electrophysiol 2016 Dec;9(12)
    From the Department of Pharmacology, University of Michigan Medical School, Ann Arbor (Y.B., C.R.F., L.F.L.-S., C.C., L.L.I.); Center for Arrhythmia Research and Department of Medicine/Cardiovascular Medicine, University of Michigan, Ann Arbor (B.C.W., R.R.-M., J.A., H.H.V., J.J.); Leon H. Charney Division of Cardiology, New York University School of Medicine, NY (X.L., M.D.); Department of Pharmacology and Physiology, University of Rochester Medical Center, NY (D.S.A.); and Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (Z.W.).
    Background: Mutations in SCN2B, encoding voltage-gated sodium channel β2-subunits, are associated with human cardiac arrhythmias, including atrial fibrillation and Brugada syndrome. Because of this, we propose that β2-subunits play critical roles in the establishment or maintenance of normal cardiac electric activity in vivo.

    Methods And Results: To understand the pathophysiological roles of β2 in the heart, we investigated the cardiac phenotype of Scn2b null mice. Read More

    Idiopathic VPC: Distribution Of FOCI And Tips Of Ablation.
    J Atr Fibrillation 2016 Apr-May;8(6):1342. Epub 2016 Apr 30.
    Sao Paulo Heart Hospital.
    Idiopathic Ventricular Premature Contraction (VPC) is currently more routinely referred for electrophysiology evaluation. Usually it carries a good prognosis but, when symptomatic or suspected to produce ventricular dysfunction, will require treatment. Nowadays, RF ablation has great advantages over antiarrhythmic drugs. Read More

    SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts.
    Eur Rev Med Pharmacol Sci 2016 Nov;20(22):4796-4800
    Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.
    Objective: Thrombin is implicated in the genesis of arrhythmias and activation of thrombin receptors exacerbated ventricular arrhythmias following coronary artery ligation. The present study was designed to investigate the possible protective effect of the protease-activated receptor-1 antagonist, SCH79797 against ischemia and reperfusion arrhythmias in the rat heart.

    Materials And Methods: Healthy male Wistar rats (250-350 g) were anesthetized with urethane. Read More

    The Analog Blanking Period of Implantable Cardiac Rhythm Devices.
    Pacing Clin Electrophysiol 2017 Feb 17;40(2):115-127. Epub 2017 Jan 17.
    Biotronik, Berlin, Germany.
    Background: Analog blanking periods (BPs) that hold down the display of electrograms (EGMs) in cardiac rhythm devices have received much less attention than the well-known digital BPs which do not influence the EGM display. In Biotronik devices (Biotronik GmbH, Berlin, Germany), when a paced event initiates an analog BP in one chamber (right atrium, right ventricle [RV], or left ventricle [LV]), an identical cross-chamber analog BP starts in the other two chambers.

    Methods: All clinical observations were recorded from patients with Biotronik devices. Read More

    Catheter Ablation in the Right Ventricular Outflow Tract Associated With Occlusion of Left Anterior Descending Coronary Artery.
    J Cardiovasc Electrophysiol 2016 Nov 25. Epub 2016 Nov 25.
    Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    Major vessel injury during right ventricular outflow tract ablation is not something widely recognized, and routine evaluation of the left anterior descending (LAD) artery location in relation to the septal right ventricle is not routinely performed. In the present article, we report a case of acute LAD occlusion after right ventricular outflow tract ablation and then illustrate the intimately close relationship of the LAD artery to the anterior septal site of the RVOT (approximately 2-3 cm under the pulmonic valve), using a combination of intracardiac echocardiography and 3-dimensional electroanatomical mapping recorded during a second case, in order to specifically point to the area at risk. Read More

    Use of self-gated radial cardiovascular magnetic resonance to detect and classify arrhythmias (atrial fibrillation and premature ventricular contraction).
    J Cardiovasc Magn Reson 2016 Nov 25;18(1):83. Epub 2016 Nov 25.
    Department of Radiology, The Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, 660 First Ave, New York, NY, USA.
    Background: Arrhythmia can significantly alter the image quality of cardiovascular magnetic resonance (CMR); automatic detection and sorting of the most frequent types of arrhythmias during the CMR acquisition could potentially improve image quality. New CMR techniques, such as non-Cartesian CMR, can allow self-gating: from cardiac motion-related signal changes, we can detect cardiac cycles without an electrocardiogram. We can further use this data to obtain a surrogate for RR intervals (valley intervals: VV). Read More

    Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a population-based study.
    BMC Cardiovasc Disord 2016 Nov 22;16(1):233. Epub 2016 Nov 22.
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
    Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Read More

    Non-Invasive Personalisation of a Cardiac Electrophysiology Model from Body Surface Potential Mapping.
    IEEE Trans Biomed Eng 2016 Nov 16. Epub 2016 Nov 16.
    Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. Read More

    [Indications for implantable loop recorders in patients with channelopathies and ventricular tachycardias].
    Herzschrittmacherther Elektrophysiol 2016 Dec;27(4):360-365
    Abteilung für Rhythmologie, Department für Kardiologie und Angiologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland.
    Implantable loop recorders (ILR) do not play a pivotal role in the current guidelines on ventricular arrhythmias except in identifying rhythm-symptom correlations if ventricular arrhythmias are assumed. Before a decision for a pure diagnostic implantable device is made, a thorough arrhythmic risk assessment is of major importance due to the potential lethal outcome of ventricular arrhythmias. Nevertheless, some clinical circumstances exist where long-term monitoring by an ILR may add significant information in electrical heart diseases, in patients with ventricular arrhythmias, or structural heart diseases and a potential risk of ventricular arrhythmias. Read More

    Review of His-Purkinje System Abnormality with Case Studies.
    Card Electrophysiol Clin 2016 Dec;8(4):747-752
    Mayo Clinic, Rochester, MN, USA.
    A single beat arising as extra systole within the His-Purkinje system or from ventricle or even atrium based on conduction timing can invoke delayed conduction or block within intra-Hisian or infra-Hisian sites. This may be either manifested in the form of premature atrial or ventricular complexes or concealed as with His extra systoles. It appears commonly there is disease within the His-Purkinje system. Read More

    MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy.
    Microrna 2016 Nov 9. Epub 2016 Nov 9.
    Department of Medicine, University of Chicago, Chicago, United States.
    Background: MicroRNAs are small noncoding RNA molecules that play a critical role in regulating physiological and disease processes. Recent studies have now recognized microRNAs as an important player in cardiac arrhythmogenesis. Molecular insight into arrhythmogenic cardiomyopathy (AC) has primarily focused on mutations in desmosome proteins. Read More

    Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.
    Proc Natl Acad Sci U S A 2016 Nov 31;113(46):E7250-E7259. Epub 2016 Oct 31.
    Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain;
    Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A alterations also occur in physiological aging. It remains unknown how defective prelamin A processing affects the cardiac rhythm. Read More

    Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.
    Circ Res 2017 Jan 31;120(1):120-132. Epub 2016 Oct 31.
    From the Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Mannheim, Heidelberg University, Germany (C.V., T.W.); Institute of Pharmacology, University Medical Center Göttingen (UMG) Heart Center, Georg August University Medical School Göttingen, Germany (C.V., M.D., M.R., S.M.); UMR-S 1180, INSERM, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France (M.L., H.M., S.K., P.L., J.L., G.V., R.F.); Department of Molecular Cardiology and Epigenetics, University Hospital Heidelberg, Germany (M.D.); Institute of Pharmacology and Toxicology, University of Würzburg and Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany (K.L., C.S.); Comprehensive Heart Failure Center, University of Würzburg, and West German Heart and Vascular Center Essen, Germany (K.L.); Department of Pharmacology and Toxicology, University of Technology Dresden, Germany (S.L., M.W., A.E.-A.); Department of Cardiology and Pneumology, Center of Molecular Cardiology, UMG Heart Center, Georg August University Medical School Göttingen, Germany (F.E.M., S.S.); Department of Internal Medicine III, Cardiology and Angiology, University of Kiel, Germany (S.S.); BAYER Pharma AG, Wuppertal, Germany (A.G., M.H., F.W.); University Heart Center, Department of General and Interventional Cardiology, University Medical Center Hamburg-Eppendorf, Germany (F.J.B.); and DZHK (German Centre for Cardiovascular Research), partner sites Heidelberg/Mannheim, Göttingen and Hamburg/Kiel/Lübeck, Germany (C.V., M.D., M.R., S.M., F.E.M., S.S., F.J.B., T.W.).
    Rationale: Phosphodiesterase 2 is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyzes cAMP. Myocardial phosphodiesterase 2 is upregulated in human heart failure, but its role in the heart is unknown.

    Objective: To explore the role of phosphodiesterase 2 in cardiac function, propensity to arrhythmia, and myocardial infarction. Read More

    Effects of Statin on Arrhythmia and Heart Rate Variability in Healthy Persons With 48-Hour Sleep Deprivation.
    J Am Heart Assoc 2016 Oct 31;5(11). Epub 2016 Oct 31.
    Department of Cardiology, PLA General Hospital, Beijing, China.
    Background: It has been reported that sleep deprivation is associated with cardiac autonomic disorder, inflammation, and oxidative stress. Statins have significant cardiovascular protective effects in patients with cardiovascular disease. This study aimed to investigate the protective effect of statins on arrhythmia and heart rate variability in young healthy persons after 48-hour sleep deprivation. Read More

    Trade-off between elimination of premature ventricular complexes and loss of synchronized left ventricular pacing improved cardiac function in a patient with heart failure.
    Indian Pacing Electrophysiol J 2016 May - Jun;16(3):99-101. Epub 2016 Aug 20.
    Division of Clinical Engineering, Shizuoka Saiseikai General Hospital Shizuoka, Japan.
    Synchronized left ventricular pacing (sLVP) via adaptive cardiac resynchronization therapy (aCRT) algorithm might enhance the efficacy of CRT. A 71-year-old female was admitted with the diagnosis of heart failure. Electrocardiograms revealed left bundle branch block with QRS width of 144 ms, and frequent premature ventricular complexes (PVCs). Read More

    [Clinical analysis of 19 cases of pregnant women with rapid arrhythmia in the treatment of radiofrequency catheter ablation].
    Zhonghua Fu Chan Ke Za Zhi 2016 Oct;51(10):759-764
    Department of Obstetrics and Gynecology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
    Objective: To investigate the risk of radiofrequency catheter ablation and maternal and infant in pregnant women with rapid arrhythmia during pregnancy. Methods: The clinical data of the 19 cases of pregnancy complicated with rapid arrhythmia were retrospectively analyzed and followed up, including the gestational week, the type of arrhythmia, the treatment, and the outcome of the mother and child in Beijing Anzhen Hospital of Capital Medical University from January 2002 to March 2016. Results: (1)Clinical characteristics: the ages of the 19 cases were(31±4)years old(ranged from 26 to 35 years old), the onset gestational ages were(21±4)weeks(ranged from 15 to 32 weeks). Read More

    Radionuclide Assessment of Cardiac Function and Dyssynchrony in Children with Idiopathic Ventricular Tachycardia.
    Pacing Clin Electrophysiol 2016 Nov 28;39(11):1213-1224. Epub 2016 Oct 28.
    Nuclear Medicine Department, Federal State Budgetary Scientific Institution "Research Institute for Cardiology", Tomsk, Russia.
    Background: The aim of the study was to evaluate the impact of idiopathic ventricular tachycardia and premature ventricular beats on cardiac function and dyssynchrony and to elucidate relationships between data of scintigraphic and intracardiac electrophysiology studies (EPSs).

    Methods: The study comprised 64 patients with idiopathic ventricular arrhythmias (VAs; median age of 14 years ranging from 8 to 18 years). The control group comprised 20 patients (median age of 12 ranging from 7 to 16 years) without cardiac arrhythmias. Read More

    Proof of concept study: renal sympathetic denervation for treatment of polymorphic premature ventricular complexes.
    J Interv Card Electrophysiol 2016 Nov 30;47(2):221-229. Epub 2016 May 30.
    Department of Cardiac Surgery and Artificial Cardiac Stimulation, Department of Medicine, Hospital e Clínica São Gonçalo, São Gonçalo, RJ, Brazil.
    Background Or Purpose: Polymorphic premature ventricular complexes (PVCs) are very common, appearing most frequently in patients with hypertension, obesity, sleep apnea, and structural heart disease. Sympathetic hyperactivity plays a critical role in the development, maintenance, and aggravation of ventricular arrhythmias. Recently, the relevance of sympathetic activation in patients with ventricular arrhythmias was reported, and this finding suggested a potential role for catheter-based renal sympathetic denervation in reducing the arrhythmic burden. Read More

    A prospective 5-year study of the frequency of arrhythmias during serial exercise testing and clinical follow-up after Melody valve implant.
    Heart Rhythm 2016 Nov 21;13(11):2135-2141. Epub 2016 Jul 21.
    Children's Hospital of Orange County, University of California Irvine, Orange, California. Electronic address:
    Background: Although percutaneous Melody valve implant has become an accepted alternative to surgical pulmonary valve replacement in patients with congenital heart disease, the benefit regarding frequency and severity of arrhythmias remains undefined.

    Objective: The purpose of this study was to evaluate the impact of Melody valve implant on the type and frequency of arrhythmias during cardiopulmonary exercise testing (CPET) and subsequent clinical outcome.

    Methods: As part of the phase I Melody valve clinical trial, 136 patients with congenital heart disease underwent prospective serial evaluation including CPET before implant, 6 months after implant, and annually thereafter for 5 years. Read More

    Clinical and biophysical evaluation of variable bipolar configurations during radiofrequency ablation for treatment of ventricular arrhythmias.
    Heart Rhythm 2016 Nov 14;13(11):2161-2171. Epub 2016 Jul 14.
    Section of Cardiac Electrophysiology, Division of Cardiology, University of Colorado, Aurora, Colorado. Electronic address:
    Background: Bipolar radiofrequency ablation (bRFA) has been used to create larger ablation lesions and to treat refractory arrhythmias. However, little is known about optimal bRFA settings.

    Objective: The purpose of this study was to evaluate various bRFA settings, including active and ground catheter tip orientation and use of variable active and ground catheters during bRFA. Read More

    New electrocardiographic criteria for predicting successful ablation of premature ventricular contractions from the right coronary cusp.
    Int J Cardiol 2016 Dec 16;224:199-205. Epub 2016 Sep 16.
    Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background: ECG features for predicting successful ablation sites of outflow tract (OT) premature ventricular complex (PVCs) have been previously presented, but effective predictors of right coronary cusp (RCC) remain elusive.

    Methods: 106 patients (59 males, 56±14years) who underwent successful PVC ablation were studied. Various ECG patterns and measurements were analyzed to identify the unique features of RCC PVC origins. Read More

    Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.
    Am J Physiol Heart Circ Physiol 2016 Dec 7;311(6):H1470-H1484. Epub 2016 Oct 7.
    Department of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los Angeles, California;
    The occurrence of early afterdepolarizations (EADs) and increased dispersion of repolarization are two known factors for arrhythmogenesis in long QT syndrome. However, increased dispersion of repolarization tends to suppress EADs due to the source-sink effect, and thus how the two competing factors cause initiation of arrhythmias remains incompletely understood. Here we used optical mapping and computer simulation to investigate the mechanisms underlying spontaneous initiation of arrhythmias in type 2 long QT (LQT2) syndrome. Read More

    ME 04-3 EPIDEMIOLOGY AND CONSEQUENCES OF EARLY VASCULAR AGING.
    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e541
    Miyagi University of Education, Japan.
    Arterial structure and function change progressively with advancing age. Owing to long-lasting repetitive stretch with intermittent cardiac contraction, elastic fibers in the tunica media of large arteries gradually degenerate and are replaced by collagenous fibers. Such medial degeneration causes elastic arteries to stiffen and dilate. Read More

    Clinical values of left ventricular mechanical dyssynchrony assessment by gated myocardial perfusion SPECT in patients with acute myocardial infarction and multivessel disease.
    Eur J Nucl Med Mol Imaging 2017 Feb 18;44(2):259-266. Epub 2016 Oct 18.
    Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322, Seoyang-ro Hwasun-eup, Hwasun-gun, Jeonnam, South Korea, 58128.
    Purpose: The aim of this study was to evaluate the prognostic value of additional evaluation of left ventricular mechanical dyssynchrony (LVMD) by gated myocardial perfusion single-photon emission computed tomography (GMPS) in patients with acute myocardial infarction (MI) and multivessel disease.

    Methods: One hundred and nine acute MI patients with >50 % stenosis in at least one non-culprit artery who underwent GMPS within 2 weeks were enrolled. All patients underwent successful revascularization of the culprit arteries. Read More

    Disruption of calcium homeostasis by cardiac-specific over-expression of PPAR-γ in mice: A role in ventricular arrhythmia.
    Life Sci 2016 Dec 14;167:12-21. Epub 2016 Oct 14.
    Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou 510120, China. Electronic address:
    Aims: Adverse cardiovascular effects induced by peroxisome proliferator activator receptor-γ (PPAR-γ) activation were observed in clinical setting. But the underlying mechanism is unclear. Now, transgenic mice with cardiac specific peroxisome proliferator activator receptor-γ overexpression (TG-PPAR-γ) were used to explore the possible mechanisms. Read More

    Quantitative analysis of ventricular ectopic beats in short-term RR interval recordings to predict imminent ventricular tachyarrhythmia.
    Int J Cardiol 2016 Dec 3;225:226-233. Epub 2016 Oct 3.
    Departamento de Instrumentación Electromecánica, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F. 14080, Mexico. Electronic address:
    Background: Most approaches to predict ventricular tachyarrhythmias which are based on RR intervals consider only sinus beats, excluding premature ventricular complexes (PVCs). The method known as heartprint, which analyses PVCs and their characteristics, has prognostic value for fatal arrhythmias on long recordings of RR intervals (>70,000 beats).

    Objective: To evaluate characteristics of PVCs from short term recordings (around 1000 beats) and their prognostic value for imminent sustained tachyarrhythmia. Read More

    Twenty-four hour Holter monitoring in finishing cattle housed outdoors.
    J Vet Cardiol 2016 Oct 6. Epub 2016 Oct 6.
    Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave., Manhattan, KS 66506, USA.
    Introduction: Atrial premature complexes have been reported to be the most common arrhythmia in cattle and is suspected to be secondary to systemic disease, especially gastrointestinal disease. In order to properly identify pathologic arrhythmia in cattle, the normal rhythm and arrhythmia prevalence should be defined. The objective of this study was to determine the normal heart rate, rhythm, number of ventricular premature complexes (VPCs), and atrial premature complexes (APCs) in unrestrained Angus steers. Read More

    Identifying and Managing Premature Ventricular Contraction-Induced Cardiomyopathy: What, Why, and How?
    Can J Cardiol 2017 Feb 1;33(2):287-290. Epub 2016 Jul 1.
    Arrhythmia Service, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
    Premature ventricular contraction (PVC)-induced cardiomyopathy is increasingly being recognized as a reversible cause of left ventricular (LV) systolic dysfunction (LVSD). The diagnosis of PVC-induced cardiomyopathy is considered in subjects with high PVC burdens (> 10,000 per 24 hours) after excluding other known causes of LVSD. PVC suppression is the mainstay of the management of PVC-induced cardiomyopathy, in addition to proven evidence-based medical therapy recommended for subjects with LVSD. Read More

    Cardiac arrest after sugammadex administration in a patient with variant angina: a case report.
    Korean J Anesthesiol 2016 Oct 25;69(5):514-517. Epub 2016 Jul 25.
    Department of Anesthesiology and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, Korea.
    A 76-year-old man with no notable medical history was scheduled for a robot-assisted radical prostatectomy. After the operation, he was given sugammadex. Two minutes later, ventricular premature contraction bigeminy began, followed by cardiac arrest. Read More

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