174,965 results match your criteria Premature Ventricular Contraction


Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.

Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.

Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More

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December 2018
3 Reads

Loss of enzyme activity in mutated B4GALNT1 gene products in patients with hereditary spastic paraplegia results in relatively mild neurological disorders: Similarity with phenotypes of B4galnt1 knockout mice.

Neuroscience 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan; Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya 466-0065, Japan. Electronic address:

B4GALNT1 is an enzyme essential for the synthesis of complex gangliosides, whose absence leads to progressive neurodegeneration with aging in mice. Recently, eleven cases of hereditary spastic paraplegia with mutation in the coding region of B4GALNT1 were reported. However, changes in the enzymatic activity of their products have never been studied. Read More

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December 2018
2 Reads

Structural characterization, teratogenicity and in vitro avian antimicrobial activity of posterior salivary gland (PSG) toxin from cuttlefish, Sepia prashadi.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Native Medicine and Marine Pharmacology Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Chennai 603 103, Tamil Nadu, India. Electronic address:

A low molecular weight posterior salivary gland (PSG) toxin was isolated and purified from the cuttlefish Sepia prashadi by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). The protein and neutral sugar content of the PSG toxin was determined to be 1.033 mg/g and 282 μg/g. Read More

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December 2018

Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway.

Life Sci 2018 Dec 3. Epub 2018 Dec 3.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More

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December 2018

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain.

J Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Instituto Biofisika (UPV/EHU, CSIC) y Dpto. de Bioquímica y Biología Molecular, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Barrio Sarriena S/N, 48490, Leioa, Spain. Electronic address:

Protein aggregate reactivation in metazoans is accomplished by the combined activity of Hsp70, Hsp40 and Hsp110 chaperones. Hsp110s support the refolding of aggregated polypeptides acting as specialized nucleotide exchange factors of Hsp70. We have studied how Apg2, one of the three human Hsp110s, regulates the activity of Hsc70 (HspA8), the constitutive Hsp70 in our cells. Read More

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December 2018

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
4 Reads

The burden of stroke in China: Results from a nationwide population-based epidemiological survey.

PLoS One 2018 6;13(12):e0208398. Epub 2018 Dec 6.

Department of Neuroepidemiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Stroke is a serious threat to human health that often leads to severe complications, and currently ranks first as leading cause of death in China. However, reliable data on stroke burden in China in the 21st century are lacking. We used the data from NESS-China (National Epidemiological Survey of Stroke in China) for assessing the adverse health effects of stroke in Chinese population. Read More

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December 2018
1 Read

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018

Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.

Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?

Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.

What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More

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December 2018

[Individualised treatment of patients with bronchoectasis].

Ugeskr Laeger 2018 Dec;180(49)

Bronchiectasis is characterised by chronic cough, airway inflammation, infection and bronchial dilatation. The disease may lead to impaired lung function and premature death. An underlying inflammatory disease or immunodeficiency may be present, but 40% of the cases are idiopathic. Read More

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December 2018

In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra.

J Biomed Opt 2018 Dec;23(12):1-6

California Institute of Technology, Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Depa, United States.

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. Read More

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December 2018
3 Reads
2.859 Impact Factor

Outcomes following neonatal portal vein thrombosis: A descriptive, single-center study and review of anticoagulant therapy.

Pediatr Blood Cancer 2018 Dec 5:e27572. Epub 2018 Dec 5.

Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Background: Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood.

Objective: The primary aim of our study was to describe the short-term and long-term outcomes of neonatal PVT.

Methods: A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. Read More

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December 2018

Neurodevelopmental outcome in children with spina bifida aperta repaired prenatally versus postnatally: a systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Academic Department Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.

Objective: To assess the neurodevelopmental outcome of children with spina bifida aperta (SBA) who were treated prenatally as compared to those treated postnatally.

Methods: We performed a systematic review of the literature comparing neurological outcomes of prenatally and postnatally repaired spina bifida in Pubmed/MEDLINE, Embase, Web of Science and Cochrane Library. We retrieved all randomized and non-randomized prospective controlled studies. Read More

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December 2018
2 Reads

The use of heart rate variability analysis to detect arrhythmias in horses undergoing a standard treadmill exercise test.

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Equine Department, Clinic for Equine Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Little is known about normal heart rate variability (HRV) in horses during exercise. It can be difficult to separate premature beats from normal beat-to-beat variation at higher heart rates.

Objectives: The aim was to quantify HRV in healthy horses during a high-speed treadmill-standardized exercise test (HSET) and to compare with the HRV in horses observed to have arrhythmias during exercise. Read More

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December 2018
1 Read

Exploration of a cultural-adaptation of the EQ-5D for Thai population: A "bolt-on" experiment.

Qual Life Res 2018 Dec 5. Epub 2018 Dec 5.

Division of Social and Administrative Pharmacy, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Rd., Rajathevi, Bangkok, 10400, Thailand.

Purpose: As the EQ-5D was developed in western countries with only five dimensions, it might be insensitive to non-western populations including Thai. This study examined the impact of adding two candidate dimensions, "interpersonal relationships (IR)" and "activities related to bending knees (AK)," to the EQ-5D questionnaire, and evaluated their psychometric properties in a Thai population sample.

Methods: Face-to-face interviews were conducted with 600 Thai. Read More

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December 2018

How to Best Convey Information About Intensive/Comfort Care to the Family Members of Premature Infants to Enable Unbiased Perinatal Decisions.

Front Pediatr 2018 16;6:348. Epub 2018 Nov 16.

Department of Neurology, PLA Army General Hospital, Beijing, China.

As the infant's best interests are determined through the perinatal decisions of family members and physicians, it is important to understand the factors that affect such decisions. This paper investigated the separate and combined effects of various factors related to perinatal decision making and sought to determine the best way to convey information in an unbiased manner to family members. In total, 613 participants were consecutively recruited. Read More

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November 2018

"PI-less DMEK": results of Descemet's membrane endothelial keratoplasty (DMEK) without a peripheral iridotomy.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

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December 2018
1 Read

Not all neonates with oesophageal atresia and tracheoesophageal fistula are a surgical emergency.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Paediatric Surgery, Evelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:

Aim: Infants with oesophageal atresia and distal tracheoesophageal fistula (OA-TOF) occasionally require endotracheal intubation prior to definitive surgery. This creates the risk of preferential ventilation of the fistula leading to gastric distention and subsequent perforation. We aimed to reassess the risk of preoperative positive-pressure ventilation and update recommendations for emergency surgery in this cohort. Read More

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November 2018

Aortopexy for tracheomalacia via a suprasternal incision.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Paediatric Surgery, Evelina London Children's Hospital, Lambeth, London, UK. Electronic address:

Aim: Tracheomalacia is flaccidity of the tracheal wall leading to tracheal collapse, particularly on expiration. When severe it can warrant surgical intervention. Aortopexy is one surgical option and has been described using a variety of approaches. Read More

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November 2018

Cognitive function in adolescence and the risk for premature diabetes and cardiovascular mortality in adulthood.

Cardiovasc Diabetol 2018 Dec 5;17(1):154. Epub 2018 Dec 5.

The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Epidemiological studies have demonstrated a relationship between cognitive function in youth and the future risk of death. Less is known regarding the relationship with diabetes related death. This study assessed the relationship between cognitive function in late adolescence and the risk for diabetes, cardiovascular- (CVD) and all-cause mortality in adulthood. Read More

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December 2018
1 Read

Un exemple de controverse en clinique liée à l’EBM. Pour réduire les complications vasculaires du diabète, faut-il chercher à réduire l’hyperglycémie ?

Authors:
André Grimaldi

Rev Prat 2016 Nov;67(9):1019-1022

CHU La Pitié-Salpêtrière, Paris, France.

An example of clinical controversy related to EBM. The DCCT study for type 1 diabetes (1993) and UKPDS for type 2 (1998) had demonstrated the benefit of the hypoglycemic treatment with, for 1 point of HbA1c less, 30% less microangiopathy events. The cardiovascular benefit was less obvious, as these studies were performed in patients with primary prevention. Read More

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November 2016

Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Am J Respir Cell Mol Biol 2018 Dec 3. Epub 2018 Dec 3.

Mayo Clinic College of Medicine and Science, 12270, Department of Anesthesiology and Perioperative Medicine, Rochester, Minnesota, United States.

Supplemental O2 (hyperoxia; 30-90% O2) is a necessary intervention for premature infants, but contributes to development of neonatal and pediatric asthma, necessitating better understanding of contributory mechanisms in hyperoxia-induced changes to airway structure and function. In adults, environmental stressors promote formation of senescent cells that secrete factors (senescence-associated secretory phenotype; SASP), which can be inflammatory and have paracrine effects that enhance chronic lung diseases. Hyperoxia-induced changes in airway structure and function are mediated in part by effects on airway smooth muscle (ASM). Read More

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December 2018
1 Read

Frequent premature atrial contractions are associated with atrial fibrillation, brain ischaemia, and mortality: a systematic review and meta-analysis.

Europace 2018 Dec 1. Epub 2018 Dec 1.

Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, Netherlands.

Aims: Premature atrial contractions (PACs) are a common cardiac phenomenon, traditionally considered to be of little clinical significance. Recent studies, however, suggest that PACs are associated with atrial fibrillation (AF), as well as ischaemic stroke, transient ischaemic attack, and mortality. This systematic review aims to investigate the association between PACs on standard electrocardiogram (ECG) as well as PAC-count on Holter monitor and future detection of AF, brain ischaemia, and all-cause mortality in patients without a history of AF. Read More

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December 2018
1 Read

Cannabinoid drugs: will they relieve or exacerbate tinnitus?

Curr Opin Neurol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago Medical School, and the Brain Health Research Centre, Dunedin.

Purpose Of Review: Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Read More

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November 2018
1 Read

Characterization of a multidrug-resistant Klebsiella pneumoniae ST607-K25 clone responsible for a nosocomial outbreak in a neonatal intensive care unit.

J Med Microbiol 2018 Dec 3. Epub 2018 Dec 3.

2​Microbiology Research Unit, AGIR -EA4294, Jules Verne University of Picardie, Amiens, France.

Purpose: Multidrug-resistant Klebsiella pneumoniae strains are regularly involved in hospital outbreaks. This study describes an ESBL-producing K. pneumoniae clone (ST607-K25) responsible for a nosocomial outbreak in a neonatal intensive care unit. Read More

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December 2018

Sustaining attendance at a mental health service: A randomized controlled trial.

J Consult Clin Psychol 2018 Dec;86(12):1056-1060

Department of Psychology and Neuroscience.

Objective: A substantial proportion of psychotherapeutic treatments are prematurely terminated because the client discontinues attendance. Interventions have been developed to reduce premature termination, but these are only moderately effective and often place considerable burden on clients and services. This research evaluated a brief, low-cost self-regulation intervention (i. Read More

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December 2018

Determination of Benzopyrene-Induced Lung Inflammatory and Cytotoxic Injury in a Chemical Gradient-Integrated Microfluidic Bronchial Epithelium System.

ACS Sens 2018 Dec 3. Epub 2018 Dec 3.

Environmental pollution is one of the largest sources responsible for human diseases and premature death worldwide. However, the methodological development of a spatiotemporally controllable and high-throughput investigation of the environmental pollution-induced biological injury events is still being explored. In this study, we describe a chemical gra-dient generator-aided microfluidic cell system for the dynamic study of representative environmental pollutant-induced bronchial epithelium injury in a throughput manner. Read More

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December 2018
1 Read

Randomised controlled trial on the impact of kinesthetic stimulation on early somatic growth of preterm infants in Kangaroo position.

Acta Paediatr 2018 Dec 1. Epub 2018 Dec 1.

CRUJeF Laval University, Quebec City, PQ, Canada.

Aim: Evaluation of early growth in preterm infants receiving kinesthetic stimulation with massage in Kangaroo position or in incubator.

Methods: A cohort of 66 infants between 30 and 33 weeks of gestational age (GA), born at a university hospital in 2013 in Bogota, were randomised when eligible to intervention. We measured weight gain (g/kg/day) at 5 and 15 days post-randomisation and weight at 40 weeks, according to chronological age at randomisation. Read More

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December 2018

Associations of temporal changes in cervical length and lower uterine segment length with spontaneous preterm delivery risk: a prospective study of 727 Japanese women.

J Med Ultrason (2001) 2018 Dec 1. Epub 2018 Dec 1.

Maternal and Child Health Center Aiiku Hospital, 1-16-10 Shibaura, Minato-ku, Tokyo, 105-0023, Japan.

Purpose: A prospective assessment of the risk of spontaneous preterm delivery (sPTD) by evaluating temporal changes in cervical measurements.

Methods: We analyzed clinical variables, focusing on cervical length (CL) and lower uterine segment (LUS) length (LUSL) as measured by transvaginal ultrasonography in 727 pregnant Japanese women.

Results: In women undergoing term deliveries, CL increased from gestational week (GW) 8-25. Read More

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December 2018
2 Reads

Antisocial personality and risks of cause-specific mortality: results from the Epidemiologic Catchment Area study with 27 years of follow-up.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Little is known about the effect of antisocial personality disorder (ASPD) on the risks of cause-specific mortality in the community. This study aimed to close this gap by evaluating if ASPD increases risks of cause-specific mortality in population-based residential and institutionalized samples with 27 years of follow-up.

Methods: Data were collected in four metropolitan sites as part of the Epidemiologic Catchment Area (ECA) study during 1979-1983. Read More

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December 2018

Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Ophthalmol Retina 2018 Sep 21;2(9):963-971. Epub 2018 Mar 21.

Department of Ophthalmology, Duke University, Durham, NC, 27710, USA.

Purpose: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible . Here we present bedside, non-sedated cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT). Read More

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September 2018
1 Read

Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins.

Sci Rep 2018 Nov 30;8(1):17490. Epub 2018 Nov 30.

Laboratory of Molecular Gerontology, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Ste. 100, Baltimore, MD, 21224, USA.

Cockayne syndrome (CS) is an inherited disorder that involves photosensitivity, developmental defects, progressive degeneration and characteristics of premature aging. Evidence indicates primarily nuclear roles for the major CS proteins, CSA and CSB, specifically in DNA repair and RNA transcription. We reveal herein a complex regulation of CSB targeting that involves three major consensus signals: NLS1 (aa467-481), which directs nuclear and nucleolar localization in cooperation with NoLS1 (aa302-341), and NLS2 (aa1038-1055), which seemingly optimizes nuclear enrichment. Read More

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November 2018

Effect of premature birth on long-term systolic blood pressure variability in women.

Anatol J Cardiol 2018 Dec;20(6):347-353

Department of Cardiology, Kailuan Hospital Affiliated to Hebei United University; Tangshan-China.

Objective: To investigate the effect of premature birth (PTB) on long-term systolic blood pressure (SBP) variability (SBPV) in women.

Methods: A total of 1974 pregnant women were divided into PTB group and non-PTB (NPTB) group. The SBP standard deviation (SSD) was calculated by four annual SBP values measured in 2006-2007, 2008-2009, 2010-2011, and 2012-2013. Read More

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December 2018

Transient phenylketonuria in premature infants.

Nutrition 2018 Aug 20;59:180-181. Epub 2018 Aug 20.

Department of Pediatrics, Hospital Universitario Rio Hortega, Valladolid, Spain.

Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine (phe) metabolism caused by a deficiency in the enzyme phenylalanine hydroxylase that converts phe into tyrosine. If left untreated, PKU results in increased phe concentrations in the blood and in the brain, which cause severe intellectual disability, epilepsy, and behavioral problems. These disorders can be prevented if a diet low in phe is introduced. Read More

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Variant of Ventricular Outflow Tract Ventricular Arrhythmias Requiring Ablation From Multiple Sites: Intramural Origin.

Heart Rhythm 2018 Nov 29. Epub 2018 Nov 29.

Background: The optimal site of ablation of idiopathic left ventricular outflow tract (LVOT) ventricular arrhythmias (VAs) is challenging as activation mapping can reveal similar activation times suggesting an intramural origin.

Objective: We sought to assess whether in patients with intramural VAs and with multiple early activation sites (AS), sequential ablation of all the early AS could improve acute and long term outcomes.

Methods: A total of 116 patients undergoing ablation for symptomatic LVOT VAs were enrolled in this study. Read More

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November 2018
1 Read

Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate.

Mol Cell 2018 Nov 27. Epub 2018 Nov 27.

Department Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

In addition to phosphodiester bond formation, RNA polymerase II has an RNA endonuclease activity, stimulated by TFIIS, which rescues complexes that have arrested and backtracked. How TFIIS affects transcription under normal conditions is poorly understood. We identified backtracking sites in human cells using a dominant-negative TFIIS (TFIIS) that inhibits RNA cleavage and stabilizes backtracked complexes. Read More

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November 2018

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.

Cell Host Microbe 2018 Nov 13. Epub 2018 Nov 13.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

TRIM5 is a RING domain E3 ubiquitin ligase with potent antiretroviral function. TRIM5 assembles into a hexagonal lattice on retroviral capsids, causing envelopment of the infectious core. Concomitantly, TRIM5 initiates innate immune signaling and orchestrates disassembly of the viral particle, yet how these antiviral responses are regulated by capsid recognition is unclear. Read More

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November 2018

A novel splicing mutation in the ABCA1 gene, causing Tangier disease and familial HDL deficiency in a large family.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Italy; Pasteur Institute Cenci Bolognetti Foundation, Sapienza University of Rome, Italy. Electronic address:

Tangier disease is a rare disorder of lipoprotein metabolism that presents with extremely low levels of HDL cholesterol and apoprotein A-I. It is caused by mutations in the ATP-binding cassette transporter A1 (ABCA1) gene. Clinical heterogeneity and mutational pattern of Tangier disease are poorly characterized. Read More

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November 2018

Potential of iontophoresis as a drug delivery method for midazolam in pediatrics.

Eur J Pharm Sci 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down BA2 7AY, UK. Electronic address:

Drug delivery to the neonatal and premature pediatric populations is very challenging. This research assessed the potential of delivering midazolam by transdermal iontophoresis as an alternative strategy in pediatric therapy. In vitro experiments used intact and tape-stripped porcine skin as models for the skin barrier function of full-term and premature newborns, respectively. Read More

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November 2018

Two different P waves after a single ventricular premature beat in a 33-year-old man.

Authors:
Hein J Wellens

Heart Rhythm 2018 Dec;15(12):1891-1892

Cardiovascular Research Institute, Maastricht, The Netherlands. Electronic address:

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December 2018

Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.

Chem Biol Interact 2018 Nov 28. Epub 2018 Nov 28.

Department of Analytical Chemistry, Medical University of Białystok, Mickiewicza 2, 15-230, Białystok, Poland.

Hypertension is a civilization disease leading to remodeling and damage of blood vessels, impaired renal function and premature death. The aim of this study was to compare the effect of chronic administration of URB597, the FAAH (fatty acid amide hydrolase) inhibitor, to rats with primary (SHRs) and secondary (DOCA-salt hypertensive rats) hypertension on electrical and physicochemical properties of kidney cells membranes. Changes in the electrical charge of the membrane may affect the cell functions. Read More

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November 2018

Affective response to physical activity as an intermediate phenotype.

Soc Sci Med 2018 Nov 10. Epub 2018 Nov 10.

Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, USA.

Over the past seventy years, biomedical and epidemiological research has shown that regular physical activity (PA) is critical for physical and mental health. Despite this knowledge, physical inactivity is the fourth leading risk factor for global mortality, accounting for 9% (5.3 million) of premature deaths annually. Read More

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November 2018

The rs1805193, rs5361, and rs5355 single nucleotide polymorphisms in the E-selectin gene (SEL-E) are associated with subclinical atherosclerosis: The Genetics of Atherosclerotic Disease (GEA) Mexican study.

Immunobiology 2018 Nov 24. Epub 2018 Nov 24.

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address:

The aim of this study was to evaluate the association of rs1805193, rs5361, and rs5355 E-selectin gene single nucleotide polymorphisms (SNPs) with the risk of developing subclinical atherosclerosis (SA) in a group of Mexicans individuals. SNPs were determined by TaqMan genotyping assays in a group of 287 individuals with SA and 688 healthy controls. Under different models, the T allele of the 5'UTR G98 T (rs1805193) (OR = 1. Read More

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November 2018

Dexmedetomidine Use in a Tertiary Care NICU: A Descriptive Study.

Ann Pharmacother 2018 Dec 3:1060028018812089. Epub 2018 Dec 3.

2 Department of Peditrics, University of Calgary, Calgary, AB, Canada.

Background: Continuous infusions of dexmedetomidine are increasingly used for sedation in critically ill pediatric patients. Emerging data suggest potential benefits when used for sedation in neonates, including reduced sedative requirements and earlier enteral feeds.

Objective: To describe the use, adverse effects, and signs of withdrawal in a cohort of neonates receiving dexmedetomidine, the majority of whom were receiving concomitant opioids. Read More

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December 2018

Predictive factors of the interruption of exclusive breastfeeding in premature infants: a prospective cohort.

Rev Bras Enferm 2018 Nov-Dec;71(6):2876-2882

Universidade Federal de Goiás, School of Nursing. Goiânia, Goiás, Brazil.

Objective: to evaluate the incidence of exclusive breastfeeding and the risk factors associated to its interruption in premature infants after hospital discharge.

Method: this is a prospective cohort with 113 premature infants in a neonatal unit, whom were followed-up from 7 to 15 days after hospital discharge. The outcome was the interruption of exclusive breastfeeding. Read More

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October 2017

Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):528-530

Department of Surgery; Division of Cardiothoracic Surgery; Pediatric and Congenital Cardiac Surgery Section Jackson Memorial Hospital - University of Miami Miller School of Medicine, Miami, USA.

Pulmonary interstitial emphysema (PIE) is a common problem in premature neonates with respiratory distress syndrome. This condition is often related to barotrauma caused by mechanical ventilation or continuous positive airway pressure applied to low birth weight neonates. The clinical diagnosis can be challenging. Read More

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February 2018

Assessment of oxidative damage and enzymatic antioxidant system activity on the umbilical cord blood and saliva from preterm newborns with risk factors for early-onset neonatal sepsis.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):888-895

Dept. Of Neonatology - Municipal Hospital of Barueri/SP, Brasil.

Background: To determine the concentration of the Lipid Peroxidation Marker: Malondialdehyde (MDA), and Antioxidant Markers: Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAL) in umbilical cord blood and in unstimulated saliva in the first 24 and 48 hours of life in the PTNB of mothers with and without risk factors for early-onset neonatal sepsis.

Methods: Cross-sectional study with the signing of informed consent by the pregnant women and application of a standard questionnaire classifying the PTNB in Group 1 or 2.

Results: Twenty-one PTNB were studied. Read More

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October 2018

Assessment of dietary patterns, physical activity and obesity from a national survey: Rural-urban health disparities in older adults.

PLoS One 2018 5;13(12):e0208268. Epub 2018 Dec 5.

Health Studies Program, Department of Kinesiology, University of Rhode Island, Kingston, Rhode Island, United States of America.

Background: Obesity is a critical public health issue, affecting over one-third of all Americans, and is an underlying cause of numerous health issues across the lifespan. For older adults, obesity is linked to premature declines in physical and mental health and cognitive functioning. The occurrence of obesity and related health behaviors and chronic diseases are higher in rural areas than in urban areas. Read More

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December 2018
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