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    6220 results match your criteria Premature Ventricular Contraction

    1 OF 125

    The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat.
    PLoS One 2017 18;12(5):e0177600. Epub 2017 May 18.
    Department of Pathophysiology, Shanxi Medical University, Taiyuan, China.
    Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (IK1) in cardiomyocytes. However, clinical anti-arrhythmic agents that primarily act on RMP by enhancing the IK1 channel are not currently available. We hypothesized that zacopride, a selective and moderate agonist of the IK1/Kir2. Read More

    Outflow tract ventricular arrhythmias : Electrocardiographic features in relation to mapping and ablation.
    Herzschrittmacherther Elektrophysiol 2017 May 22. Epub 2017 May 22.
    Department of Cardiovascular Sciences, Mayo Clinic, 55901, Rochester, MN, USA.
    Ventricular arrhythmia arising from the outflow tracts can manifest itself as frequent premature ventricular complexes (PVCs), salvos of ventricular tachycardia (VT), and/or sustained VT. It is amenable to management with medication and catheter ablation without need for an intracardiac defibrillator. The electrocardiogram (ECG) is a crucial tool in the management of these patients as it is can help localize the site of origin, thereby helping guide the electrophysiologist. Read More

    Origins location of the outflow tract ventricular arrhythmias exhibiting qrS pattern or QS pattern with a notch on the descending limb in lead V1.
    BMC Cardiovasc Disord 2017 May 15;17(1):124. Epub 2017 May 15.
    Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical university, 109 Xueyuan Road, Wenzhou, Zhejiang, 325000, China.
    Background: Ventricular outflow tract(VOT) ventricular arrhythmias(VAs) presenting qrS pattern or QS pattern with a notch on the descending limb in lead V1 were consistently thought of arising from the commissure between left and right coronary cusp (L-RCC) by previous studies. However, we found they could originate from other anatomic structures in VOT. This study aimed to investigate the exact origin of this kind VAs. Read More

    Foetal premature atrial contractions during the second and third trimester are not associated with foetal breathing.
    J Obstet Gynaecol 2017 May 14:1-4. Epub 2017 May 14.
    a Department of OB/GYN, Division Maternal-Fetal Medicine , University of Wisconsin School of Medicine and Public Health.
    Foetal premature atrial contractions (PACs) are the most commonly encountered and also the most benign foetal arrhythmia. A retrospective cohort study was conducted with the objective to assess whether the presence of foetal breathing was associated with the presence of foetal PACs. A further objective was to evaluate whether this association would affect neonatal outcomes at a high volume referral centre. Read More


    Assessment of subtle cardiac dysfunction in patients with frequent premature ventricular complexes by real-time three-dimensional speckle tracking echocardiography.
    Clin Cardiol 2017 May 4. Epub 2017 May 4.
    Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
    Background: To evaluate subtle and early premature ventricular complex (PVC)-induced ventricular impairment in patients with frequent PVCs and without structural heart disease by real-time 3-dimensional (3D) speckle tracking echocardiography (RT3D-STE).

    Hypothesis: Patients with frequent premature ventricular complexes with normal left ventricular ejection fraction have subtle left ventricular dysfunction.

    Methods: Forty patients (22 male) with a single source of frequent PVCs and 40 healthy controls (24 male) underwent assessment by conventional 2-dimensional (2D) echocardiography and RT3D-STE. Read More

    Erratum to "Risk factor algorithm used to predict frequent premature ventricular contraction-induced cardiomyopathy" [Int. J. Cardiol. 233 (2017) 37-42].
    Int J Cardiol 2017 Jul 29;238:180. Epub 2017 Apr 29.
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea. Electronic address:

    Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW).
    Eur Heart J 2017 Apr 25. Epub 2017 Apr 25.
    Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, 81377 Munich, Germany.
    Aims: Alcohol is a risk factor for cardiac arrhythmias. Retrospective analyses suggest supraventricular arrhythmias consecutive to acute alcohol consumption, but prospective data are limited. We intended to prospectively associate acute alcohol consumption with cardiac arrhythmias. Read More

    Raf kinase inhibitor protein: lessons of a better way for β-adrenergic receptor activation in the heart.
    J Physiol 2017 Apr 26. Epub 2017 Apr 26.
    Institute of Pharmacology and Clinical Pharmacology, Düsseldorf University Hospital, Universtitätsstraße 1, 40225, Düsseldorf, Germany.
    Stimulation of β-adrenergic receptors (βARs) provides the most efficient physiological mechanism to enhance contraction and relaxation of the heart. Activation of βARs allows rapid enhancement of myocardial function in order to fuel the muscles for running and fighting in a fight-or-flight response. Likewise, βARs become activated during cardiovascular disease in an attempt to counteract the restrictions of cardiac output. Read More

    "J waves" induced after short coupling intervals: a manifestations of latent depolarization abnormality?
    Europace 2017 Apr 24. Epub 2017 Apr 24.
    Internal Medicine, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-kum, Tokyo, Japan.
    Aims: To confirm the presence of tachycardia-induced slur or notch in the terminal portion of the QRS complexes in a general patient population.

    Methods And Results: A tachycardia-induced J wave was defined as a slur or notch in the terminal portion of the QRS complexes newly induced at short RR intervals during atrial premature contractions (APCs) or atrial electrical stimulation in the electrophysiological study (EPS). Twenty-three out of 2000 patients with general diseases were involved. Read More

    Effect of Lactation on myocardial vulnerability to ischemic insult in rats.
    Arq Bras Cardiol 2017 Apr 20. Epub 2017 Apr 20.
    Tehran University of Medical Sciences - International Campus, Tehran, Iran.
    Background:: Cardiovascular diseases are the leading cause of mortality and long-term disability worldwide. Various studies have suggested a protective effect of lactation in reducing the risk of cardiovascular diseases.

    Objective:: This study was designed to assess the effects of pregnancy and lactation on the vulnerability of the myocardium to an ischemic insult. Read More

    Left ventricular dysfunction is associated with frequent premature ventricular complexes and asymptomatic ventricular tachycardia in children.
    Europace 2017 Apr;19(4):617-621
    The Center for Congenital Heart Disease Amsterdam-Leiden, Leiden, The Netherlands.
    Aims: To assess the risk factors for left ventricular (LV) dysfunction in a paediatric population with idiopathic frequent premature ventricular contractions (PVCs) and asymptomatic ventricular tachycardias (VTs).

    Methods And Results: Paediatric patients with the diagnosis of idiopathic frequent PVCs and asymptomatic VTs were retrospectively evaluated. Frequent PVCs were defined as ≥5% on 24 h Holter recording. Read More

    Mechanisms Underlying the Emergence of Post-acidosis Arrhythmia at the Tissue Level: A Theoretical Study.
    Front Physiol 2017 30;8:195. Epub 2017 Mar 30.
    School of Computer Science and Technology, Harbin Institute of TechnologyHarbin, China.
    Acidosis has complex electrophysiological effects, which are associated with a high recurrence of ventricular arrhythmias. Through multi-scale cardiac computer modeling, this study investigated the mechanisms underlying the emergence of post-acidosis arrhythmia at the tissue level. In simulations, ten Tusscher-Panfilov ventricular model was modified to incorporate various data on acidosis-induced alterations of cellular electrophysiology and intercellular electrical coupling. Read More

    Cardiovascular findings in ponies with equine metabolic syndrome.
    J Am Vet Med Assoc 2017 May;250(9):1027-1035
    OBJECTIVE To determine whether hypertension, high sympathetic tone, resting and exercising arrhythmias, and echocardiographic changes consistent with hypertensive cardiomyopathy were associated with equine metabolic syndrome (EMS) in ponies. DESIGN Prospective case-control study. ANIMALS 19 privately owned ponies with a diagnosis of EMS (history of laminitis, body condition score ≥ 7/9, cresty neck score ≥ 3/5, and abnormal oral sugar test result; cases) and 20 healthy control ponies. Read More

    Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping.
    Circ Arrhythm Electrophysiol 2017 Apr;10(4)
    From the Cardiac Arrhythmia Center (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.S.B., J.A.A., J.L.A., K.S.), Neurocardiology Research Center of Excellence (D.H., P.S.R., R.W.C., O.A.A., T.I., R.T., S.S., M.V., J.A.A., J.L.A., K.S.), and Molecular, Cellular & Integrative Physiology Program (P.S.R., R.W.C., M.V., J.L.A., K.S.), David Geffen School of Medicine, University of California-Los Angeles.
    Background: Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous system, a neural network on the heart, remains unknown. Read More

    Characteristics of diurnal ventricular premature complex variation in right ventricular outflow tract arrhythmias after catheter ablation.
    Medicine (Baltimore) 2017 Apr;96(15):e6516
    aDivision of Cardiology, Kaohsiung Medical University Hospital bDivision of Cardiology, Taipei Veterans General Hospital cInstitute of Clinical Medicine, and Cardiovascular Research Center, Faculty of Medicine, College of Medicine, National Yang-Ming Medical University, Taipei dDepartment of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Diurnal variations in ventricular tachyarrhythmias (VAs) have been demonstrated in idiopathic arrhythmogenic heart disease. The electrophysiological characteristics of diurnal variations in idiopathic right ventricular outflow tract (RVOT) VA have not previously been elucidated. Sixty-two consecutive patients undergoing catheter ablation for idiopathic RVOT VA (mean age: 42. Read More

    Association of Holter-Derived Heart Rate Variability Parameters With the Development of Congestive Heart Failure in the Cardiovascular Health Study.
    JACC Heart Fail 2017 Mar 30. Epub 2017 Mar 30.
    Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri. Electronic address:
    Objectives: This study sought to determine whether Holter-based parameters of heart rate variability (HRV) are independently associated with incident heart failure among older adults in the CHS (Cardiovascular Health Study) as evidenced by an improvement in the predictive power of the Health Aging and Body Composition Heart Failure (Health ABC) score.

    Background: Abnormal HRV, a marker of autonomic dysfunction, has been associated with multiple adverse cardiovascular outcomes but not the development of congestive heart failure (CHF).

    Methods: Asymptomatic CHS participants with interpretable 24-h baseline Holter recordings were included (n = 1,401). Read More

    Carotid Dissection Complicated by Polymorphic Ventricular Tachycardia.
    J Stroke Cerebrovasc Dis 2017 Jun 5;26(6):e99-e101. Epub 2017 Apr 5.
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.
    In this case report, we describe a patient with fibromuscular dysplasia who suffered spontaneous bilateral carotid artery dissections. This was followed by significant variations in blood pressure and heart rates during her admission. Unfortunately, during an episode of bradycardia, a premature ventricular contraction occurred during the T wave which resulted in polymorphic ventricular tachycardia. Read More

    Premature Ventricular Complex Causing Ice-Pick Headache.
    Case Rep Cardiol 2017 7;2017:3879127. Epub 2017 Mar 7.
    Private Yenisehir Hospital, Department of Cardiology, Mersin, Turkey.
    Ice pick headache is a momentary, transient, repetitive headache disorder and manifests with the stabbing pains and jolts. The exact mechanism causing this disease is unknown. Premature ventricular contractions are early depolarization of the ventricular myocardium and in the absence of a structural heart disease, it is considered to be a benign disease. Read More

    The prevalence of electrocardiogram abnormalities in professional divers.
    Diving Hyperb Med 2017 Mar;47(1):55-58
    Istanbul University, Istanbul Faculty of Medicine, Underwater and Hyperbaric Medicine, Istanbul, Turkey.
    Background: The underwater environment presents physiological challenges for the cardiovascular, renal and pulmonary systems. Increases in external hydrostatic pressure reduce the capacity of the venous compartment and cause blood to move toward the lung. The aim of this study was to evaluate retrospectively electrocardiographic (ECG) changes in a cohort of professional divers. Read More

    Andersen-Tawil syndrome: Clinical presentation and predictors of symptomatic arrhythmias - Possible role of polymorphisms K897T in KCNH2 and H558R in SCN5A gene.
    J Cardiol 2017 Mar 20. Epub 2017 Mar 20.
    Department of Congenital Cardiac Defects, Institute of Cardiology, Warsaw, Poland.
    Background: Andersen-Tawil syndrome (ATS) is rare channelopathy caused by KCNJ2 mutation and probably KCNJ5. It is characterized by arrhythmias, neurological symptoms, and dysmorphic features. The present study retrospectively examined the characteristics of 11 unrelated families with ATS. Read More

    Tp-e interval and Tp-e/QT ratio before and after catheter ablation in patients with premature ventricular complexes.
    Biomark Med 2017 Apr 14;11(4):339-346. Epub 2017 Mar 14.
    Department of Cardiology, Türkiye Yüksek İhtisas Education & Research Hospital, Ankara, Turkey.
    Aim: Tp-e/QT ratio is a novel marker of ventricular repolarization. The aim of the study is to evaluate the Tp-e interval and Tp-e/QT ratio before and after radiofrequency ablation (RFA) for patients with frequent premature ventricular complexes (PVCs).

    Patients & Methods: The study included 151 consecutive patients who underwent RFA for treatment of symptomatic frequent PVCs. Read More

    Is VF an Ablatable Rhythm?
    Curr Treat Options Cardiovasc Med 2017 Feb;19(2):14
    Hôpital Cardiologique du Haut-Lévêque, Université Bordeaux II, Bordeaux, France.
    Opinion Statement: Ventricular fibrillation (VF) has traditionally been considered to be a disorganized arrhythmia not amenable to catheter ablation. However, a better understanding of the VF pathophysiology has allowed identification of targets for ablation. Ablation targeting the premature ventricular complexes which trigger VF was proven to be associated with high success rates and long-term freedom from VF recurrence. Read More

    Prognostic indices among hypertensive heart failure patients in Nigeria: the roles of 24-hour Holter electrocardiography and 6-minute walk test.
    Vasc Health Risk Manag 2017 27;13:71-79. Epub 2017 Feb 27.
    Cardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
    Background: Hypertensive heart failure (HHF) is associated with a poor prognosis. There is paucity of data in Nigeria on prognosis among HHF patients elucidating the role of 24-hour Holter electrocardiogram (ECG) in concert with other risk factors.

    Objective: The aim of this study was to determine the prognostic utility of 24-hour Holter ECG, the 6-minute walk test (6-MWT), echocardiography, clinical and laboratory parameters among HHF patients. Read More

    Beneficial Effect of Renal Denervation on Ventricular Premature Complex Induced Cardiomyopathy.
    J Am Heart Assoc 2017 Mar 2;6(3). Epub 2017 Mar 2.
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei City, Taiwan, R.O.C.
    Background: Frequent ventricular premature complexes (VPCs) can lead to the development of dilated cardiomyopathy and sudden cardiac death. Renal artery sympathetic denervation (RDN) may protect the heart from remodeling. This study aimed to investigate the effect of frequent VPCs on structural and electrical properties and whether RDN can protect the heart from remodeling. Read More

    Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.
    Circ Heart Fail 2017 03;10(3)
    From the Department NeuroFarBa (R.C., L.M., T.L., L. Santini, V.B., G.B., A.M., E.C.) and Department of Experimental and Clinical Medicine (C.F., F.G., J.M.P., C.T., C.P.), University of Florence, Italy; European Laboratory for Non-linear Spectroscopy (LENS), University of Florence & National Institute of Optics (INO-CNR), Sesto Fiorentino, Italy (C.C., L. Sacconi); Gilead Sciences Inc., Foster City, CA (L.B.); Department of Cellular and Molecular Medicine University of Arizona at Tucson, USA (J.T.); and Referral Center for Cardiomyopathies, Careggi University Hospital, Florence, Italy (M.R., I.O.).
    Background: Current therapies are ineffective in preventing the development of cardiac phenotype in young carriers of mutations associated with hypertrophic cardiomyopathy (HCM). Ranolazine, a late Na(+) current blocker, reduced the electromechanical dysfunction of human HCM myocardium in vitro.

    Methods And Results: To test whether long-term treatment prevents cardiomyopathy in vivo, transgenic mice harboring the R92Q troponin-T mutation and wild-type littermates received an oral lifelong treatment with ranolazine and were compared with age-matched vehicle-treated animals. Read More

    Effects of Transendocardial Stem Cell Injection on Ventricular Proarrhythmia in Patients with Ischemic Cardiomyopathy: Results from the POSEIDON and TAC-HFT Trials.
    Stem Cells Transl Med 2017 May 2;6(5):1366-1372. Epub 2017 Mar 2.
    Cardiovascular Division, Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
    Transendocardial stem cell injection in patients with ischemic cardiomyopathy (ICM) improves left ventricular function and structure but has ill-defined effects on ventricular arrhythmias. We hypothesized that mesenchymal stem cell (MSC) implantation is not proarrhythmic. Post hoc analyses were performed on ambulatory ECGs collected from the POSEIDON and TAC-HFT trials. Read More

    Bidirectional ventricular tachycardia in cardiac sarcoidosis.
    J Arrhythm 2017 Feb 4;33(1):69-72. Epub 2016 Jun 4.
    Department of Internal Medicine (Division of Cardiology), University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI 53713, United States.
    A 73-year-old man with history of pulmonary sarcoidosis was found to have runs of non-sustained bidirectional ventricular tachycardia (BVT) with two different QRS morphologies on a Holter monitor. Cardiac magnetic resonance delayed gadolinium imaging revealed a region of patchy mid-myocardial enhancement within the left ventricular basal inferolateral myocardium. An 18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased uptake in the same area, consistent with active sarcoid, with no septal involvement. Read More

    Relation Between Ventricular Premature Complexes and Incident Heart Failure.
    Am J Cardiol 2017 Apr 25;119(8):1238-1242. Epub 2017 Jan 25.
    Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California. Electronic address:
    Ventricular premature complexes (VPCs) may represent a reversible cause of heart failure (HF); however, the type of patients most prone remains unknown. This study leverages a large population-based database to examine interactions that might prove clinically useful in risk-stratifying patients with VPCs. We used the California Healthcare Cost and Utilization Project to identify patients with VPCs and incident systolic HF from January 1, 2005, to December 31, 2009. Read More

    Risk factor algorithm used to predict frequent premature ventricular contraction-induced cardiomyopathy.
    Int J Cardiol 2017 Apr 3;233:37-42. Epub 2017 Feb 3.
    Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea. Electronic address:
    Background: Premature ventricular contraction (PVC) QRS duration (QRSd) and high PVCs burden are known as a risk factor of PVC-induced cardiomyopathy (CMP). The aim of this study is to find useful algorithm to predict PVC-induced CMP.

    Methods: 180 patients (99 males, 51±14years) with frequent PVCs (>10%/24h), who underwent successful PVC ablation, were studied. Read More

    Incidence of Idiopathic Ventricular Arrhythmias: A Population-Based Study.
    Circ Arrhythm Electrophysiol 2017 Feb;10(2)
    From the Departments of Cardiovascular Diseases (S.S., A.M.K., D.P., P.A.B., S.K., P.A.N., D.L.P., T.M.M., B.J.G., C.J.M., W.-K.S., Y.-M.C., S.J.A., P.A.F., S.K.M.), Health Sciences Research (A.M.C.), and Pediatric and Adolescent Cardiology (S.J.A.), Mayo Clinic, Rochester, MN; and Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL (D.O.H.).
    Background: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown.

    Methods And Results: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. Read More

    [Primary Lung Cancer Associated with Dilated Phase of Hypertrophic Cardiomyopathy;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):147-150
    Department of General, Endoscopic, Cardiovascular, Thoracic and Breast Surgery, Tsugaru General Hospital, Goshogawara, Japan.
    A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3. Read More

    Premature Ventricular Complex Ablation in Structural Heart Disease.
    Card Electrophysiol Clin 2017 Mar 4;9(1):133-140. Epub 2017 Jan 4.
    Division of Electrophysiology, Department of Internal Medicine, University of Michigan Health System, CVC, SPC 5853, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5853, USA.
    Frequent premature ventricular complexes (PVCs) in patients with underlying structural heart disease, particular after myocardial infarction, can predict increased mortality. Use of antiarrhythmic medications to suppress PVCs in this setting can result in a further increase in mortality. High PVC burdens in patients with structural heart disease can cause or worsen cardiomyopathy and successful elimination of PVCs with catheter ablation can improve or, in some cases normalize, cardiac function. Read More

    Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.
    Nat Commun 2017 Jan 27;8:14155. Epub 2017 Jan 27.
    Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
    The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. Read More

    Prognostic significance of exercise-induced premature ventricular complexes: a systematic review and meta-analysis of observational studies.
    Heart Asia 2017 4;9(1):14-24. Epub 2017 Jan 4.
    University College London , London , UK.
    Background: Exercise-induced premature ventricular complexes (EI-PVCs) are common during exercise stress tests. Their optimal management and prognostic significance remain uncertain.

    Aim: To perform meta-analysis of observational studies on the prognostic significance of EI-PVCs. Read More

    Brain Emboli After Left Ventricular Endocardial Ablation.
    Circulation 2017 Feb 24;135(9):867-877. Epub 2017 Jan 24.
    From Electrophysiology Section, Division of Cardiology, University of California, San Francisco (I.R.W., R.A.G., N.B., H.H.H., B.K.L., E.P.G., G.M.M.); Department of Neurology, University of California, San Francisco (S.A.J., K.M.M., W.P.D., C.P.H.); and Division of Neuroradiology, Department of Radiology, University of California, San Francisco (W.P.D., C.P.H.).
    Background: Catheter ablation for ventricular tachycardia and premature ventricular complexes (PVCs) is common. Catheter ablation of atrial fibrillation is associated with a risk of cerebral emboli attributed to cardioversions and numerous ablation lesions in the low-flow left atrium, but cerebral embolic risk in ventricular ablation has not been evaluated.

    Methods: We enrolled 18 consecutive patients meeting study criteria scheduled for ventricular tachycardia or PVC ablation over a 9-month period. Read More

    Anatomical Consideration in Catheter Ablation of Idiopathic Ventricular Arrhythmias.
    Arrhythm Electrophysiol Rev 2016 ;5(3):203-209
    Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, US.
    Idiopathic ventricular arrhythmias (VAs) are ventricular tachycardias (VTs) or premature ventricular contractions (PVCs) with a mechanism that is not related to myocardial scar. The sites of successful catheter ablation of idiopathic VA origins have been progressively elucidated and include both the endocardium and, less commonly, the epicardium. Idiopathic VAs usually originate from specific anatomical structures such as the ventricular outflow tracts, aortic root, atrioventricular (AV) annuli, papillary muscles, Purkinje network and so on, and exhibit characteristic electrocardiograms based on their anatomical background. Read More

    Non-Invasive Personalisation of a Cardiac Electrophysiology Model from Body Surface Potential Mapping.
    IEEE Trans Biomed Eng 2016 Nov 16. Epub 2016 Nov 16.
    Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. Read More

    Heterogeneous distribution of substrates between the endocardium and epicardium promotes ventricular fibrillation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
    Europace 2017 Jan 12. Epub 2017 Jan 12.
    Faculty of Medicine, Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University.
    Aims: Whether the distribution of scar in arrhythmogenic right ventricular cardiomyopathy (ARVC) plays a role in predicting different types of ventricular arrhythmias is unknown. This study aimed to investigate the prognostic value of scar distribution in patients with ARVC.

    Methods And Results: We studied 80 consecutive ARVC patients (46 men, mean age 47 ± 15 years) who underwent an electrophysiological study with ablation. Read More

    An observational study on the effect of premature ventricular complex burden on long-term outcome.
    Medicine (Baltimore) 2017 Jan;96(1):e5476
    aDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital bDepartment of Medicine, Division of Cardiology, National Yang-Ming University School of Medicine, Taipei cDepartment of Medicine, Taipei Veterans General Hospital, Yuanshan Branch, Yilan dInstitute of Epidemiology and Preventive Medicine College of Public Health, National Taiwan University, Taipei eDivision of Cardiology, National Yang-Ming University Hospital, Yi-Lan, Taiwan.
    The long-term clinical impact of premature ventricular complexes (PVCs) on mortality and morbidity has not been fully studied. This study aimed to investigate the association between the burden of PVCs and adverse clinical outcome.A total of 5778 subjects, who were pacemaker-free and ventricular tachycardia-free at baseline, received 24-hour electrocardiography monitoring between January 1, 2002 and December 31, 2004. Read More

    A novel method to enhance phenotype, epicardial functional substrates, and ventricular tachyarrhythmias in Brugada syndrome.
    Heart Rhythm 2017 Apr 6;14(4):508-517. Epub 2017 Jan 6.
    Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Fever is associated with the manifestation of Brugada phenotype and ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with Brugada syndrome (BrS). The thermal effect on the pathogenesis of functional substrates in BrS remains unknown.

    Objective: This study aimed to elucidate the thermal effect on BrS phenotype, VT/VF, and electrophysiological characteristics of epicardial functional substrates in BrS. Read More

    Fine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.
    Environ Res 2017 Apr 3;154:115-119. Epub 2017 Jan 3.
    Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
    Background: It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex.

    Methods: We examined the association of PM <2.5µm in diameter (PM2. Read More

    Providing an Efficient Algorithm for Finding R Peaks in ECG Signals and Detecting Ventricular Abnormalities With Morphological Features.
    J Med Signals Sens 2016 Oct-Dec;6(4):218-223
    Department of Engineering, Shahed University, Tehran, Iran.
    Ventricular arrhythmias are one of the most important causes of annual deaths in the world, which may lead to sudden cardiac deaths. Accurate and early diagnosis of ventricular arrhythmias in heart diseases is essential for preventing mortality in cardiac patients. Ventricular activity on the electrocardiogram (ECG) signal is in the interval from the beginning of QRS complex to T wave end. Read More

    Voltage combined with pace mapping is simple and effective for ablation of noninducible premature ventricular contractions originating from the right ventricular outflow tract.
    Clin Cardiol 2016 Dec;39(12):733-738
    Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Background: Premature ventricular contractions (PVCs) from the right ventricular outflow tract (RVOT) can resist conventional mapping strategies. Studies regarding optimal mapping and ablation methods for patients with noninducible RVOT-PVCs are limited. We retrospectively evaluated the efficacy and safety of a novel mapping strategy for these cases: voltage mapping combined with pace mapping. Read More

    Elimination of Ventricular Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia by Targeting "Catecholamine-Sensitive Area": A Dominant-Subordinate Relationship between Origin Sites of Bidirectional Ventricular Premature Contractions.
    Pacing Clin Electrophysiol 2017 May 14;40(5):600-604. Epub 2017 Feb 14.
    Heart Rhythm Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan.
    We report on a patient diagnosed with catechoaminergic polymorphic ventricular tachycardia (CPVT) who underwent catheter ablation of ventricular premature contractions (VPCs) induced by epinephrine. VPCs were classified roughly into three types. Type 1 and Type 2 VPCs (right bundle branch block [RBBB] configuration and inferior axis) were eliminated by radiofrequency applications at the left aortic sinus of Valsalva and the anterolateral papillary muscle (APM), respectively. Read More

    Localization of premature ventricular contractions from the papillary muscles using the standard 12-lead electrocardiogram: a feasibility study using a novel cardiac isochrone positioning system.
    Europace 2016 Dec;18(suppl 4):iv16-iv22
    UCLA Cardiac Arrhythmia Center, UCLA Heath System, David Geffen School of Medicine at UCLA, Suite 660 Los Angeles, CA 90095, USA.
    Aims: The precise localization of the site of origin of a premature ventricular contraction (PVC) prior to ablation can facilitate the planning and execution of the electrophysiological procedure. In clinical practice, the targeted ablation site is estimated from the standard 12-lead ECG. The accuracy of this qualitative estimation has limitations, particularly in the localization of PVCs originating from the papillary muscles. Read More

    Catheter ablation of ventricular ectopy with para-hisian origin: importance of mapping both sides of the interventricular septum and understanding when to stop ablating.
    Clin Case Rep 2016 Dec 13;4(12):1195-1200. Epub 2016 Nov 13.
    Department of Arrhythmia and ElectrophysiologyDivision of CardiologyZentralklinik Bad BerkaBad BerkaGermany; Otto-von-Guericke University School of MedicineMagdeburgGermany.
    Catheter ablation of para-Hisian premature ventricular contractions (PVCs) still represents a challenge and is a compromise between success and inadvertent AV block. We describe a possible strategy to address PVCs from this location with high-amplitude His-bundle potentials at the site of earliest activation. Read More

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