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J Sex Med 2022 Jun 22. Epub 2022 Jun 22.

Chair of Endocrinology and Medical Sexology (ENDOSEX), Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address:

J Sex Med 2022 Jun 21. Epub 2022 Jun 21.

Université du Québec à Montréal, Department of Sexology, Montreal, Canada.

Background: Sexual aversion (SA) is a chronic difficulty impacting sexual, relational and psychological wellbeing. Yet, there is a dearth of studies exploring its prevalence and associated factors.

Aim: To estimate the prevalence of SA and examine its correlates among a community sample of Canadian adults. Read More

Andrologia 2022 Jun 23:e14509. Epub 2022 Jun 23.

Department of Urology and Sexual Medicine, TSS Shripad Hegde Kadave Institute of Medical Sciences, Sirsi, Karnataka, India.

Premature ejaculation (PE) is considered as a disorder of perceived loss of ejaculatory control. However, we cannot objectively estimate ejaculatory control due to the absence of an objective tool to measure it. Hence, we designed a pilot study to validate holding time (HoT), a novel objective tool, hypothesized by us, to measure ejaculatory control in men. Read More

Am Fam Physician 2022 Jun;105(6):591-592

Cambridge Health Alliance, Cambridge, MA, USA.

CNS Neurosci Ther 2022 Jun 10. Epub 2022 Jun 10.

Life Science Research Center, School of Life Science and Technology, Xidian University, Shaanxi, China.

Lifelong premature ejaculation patients had altered structural and functional parameters of the hypothalamus compared with healthy controls. The patients showed increased hypothalamus-related functional connectivity in several regions one hour after dapoxetine administration. The changing trends of the brain functional connectivity after dapoxetine administration possibly provided important information about the selective serotonin reuptake inhibitor effects on the functional neural system. Read More

Eur Rev Med Pharmacol Sci 2022 May;26(10):3745-3750

Health Sciences University, Adana City Training and Research Hospital Urology Clinic, Adana, Turkey.

Objective: We aimed to predict the potential testicular damage of COVID-19 by comparing the hormones FSH, LH, and TT before COVID-19 with values measured after COVID-19.

Patients And Methods: A total of 348 patients - who were followed up in our urology clinic for varicocele, premature ejaculation, erectile dysfunction and infertility, had FSH, LH and TT levels measured one year before COVID-19 and were positive for COVID-19 after a Polymerase Chain Reaction (RT-PCR) tests - were included in the study. Presence of pneumonia compatible with COVID-19, hospitalization in the intensive care unit and FSH, LH and TT values before and after COVID-19 were recorded, along with lung computed tomography (CT). Read More

J Sex Marital Ther 2022 May 30:1-8. Epub 2022 May 30.

Department of Gynecology and Obstetrics, Private Clinic, Silopi, Sırnak, Turkey.

We aimed to analyze the effect of HPV positivity in women, on women's psychology, sexual health, and male sexuality. Participants in the study were sexually active patients with high-risk HPV positivity and without any cancerous and precancerous lesions in the pathological examination. Participants and their partners' sexual health were evaluated with the FSFI questionnaire and the International Index of Erectile Function (IIEF) Score. Read More

Biology (Basel) 2022 Apr 29;11(5). Epub 2022 Apr 29.

Department of Physiology, Chonnam National University Medical School, Hwasun 58128, Korea.

Ejaculation is a reflex and the last stage of intercourse in male mammals. It consists of two coordinated phases, emission and expulsion. The emission phase consists of secretions from the vas deferens, seminal vesicle, prostate, and Cowper's gland. Read More

Molecules 2022 Apr 22;27(9). Epub 2022 Apr 22.

Guangzhou Higher Education Mega Center, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, No. 232, Waihuandong Road, Guangzhou 510006, China.

Dapoxetine is used for the treatment of premature ejaculation. The present study developed an HPLC-MS/MS method to determine the levels of dapoxetine in human plasma processed using simple protein precipitation. Dapoxetine-d was selected as the internal standard. Read More

Arab J Urol 2022 26;20(2):100-104. Epub 2022 Feb 26.

Departmant of Urology and Pediatric Urology, Universitatsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany.

Objective: To investigate the effectiveness and safety of a tadalafil 5-mg single daily dose in the treatment of lifelong premature ejaculation (PE).

Patients And Methods: A total of 55 men with lifelong PE were enrolled in this study. The intravaginal ejaculatory latency time (IELT) and Premature Ejaculation Diagnostic Tool (PEDT) were used to assess the efficacy of tadalafil. Read More

J Ethnopharmacol 2022 Aug 5;294:115209. Epub 2022 May 5.

Key Laboratory of the Ministry of Education of Xinjiang Phytomedicine Resources Utilization, Pharmacy School of Shihezi University, Xinjiang Shihezi, 832002, Xinjiang, PR China. Electronic address:

Ethnopharmacological Relevance: The Luobufukebiri pill is one of the characteristic medicines of Uygur nationality in Xinjiang. It has the effect of warming and tonifying the brain and kidney, benefiting the heart and filling the essential functions, mainly used to treat impotence, depression, spermatorrhea, premature ejaculation, bodily weakness, emaciation, and neurasthenia.

Aim Of The Study: This study evaluated the toxicology and developed a quality control protocol of Luobufukebiri pill to ensure its safety and effectiveness in clinical applications. Read More

Andrologia 2022 May 6:e14435. Epub 2022 May 6.

Department of Urology, Peking University People's Hospital, Beijing, China.

Glandular augmentation (GA) with hyaluronic acid (HA) is a newly developed, minimally invasive therapy for patients with premature ejaculation (PE); however, evidence supporting its efficacy is scarce. To provide a comprehensive profile of GA with HA gel in managing PE, 184 patients with PE who received GA with HA gel therapy from October 2017 to November 2019 were included and followed up for 1 year. The Fan technique was applied. Read More

Eur J Clin Invest 2022 May 6:e13809. Epub 2022 May 6.

Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Objective: A PHQ-9 score ≥ 15, represented as PHQ-9 , indicates major depressive disorder (MDD). On using PHQ-9, the psychological burden of several patients with lifelong premature ejaculation (LPE) gets aggravated, which may lead to LPE development. We aim to construct a nomogram for predicting the individual risk of PHQ-9 in patients with LPE and discerning those with low risks, who should avoid the PHQ-9. Read More

J Endocrinol Invest 2022 May 3. Epub 2022 May 3.

Endocrinology Unit, Medical Department, Azienda Usl, Maggiore-Bellaria Hospital, Largo Nigrisoli, 2, 40133, Bologna, Italy.

Purpose: The specific underlying mechanisms supporting the association between erectile dysfunction (ED) and premature ejaculation (PE) are still not completely clarified. To summarize and discuss all available data supporting the relationship between PE and ED.

Methods: A comprehensive narrative review was performed. Read More

Appl Bionics Biomech 2022 23;2022:8260640. Epub 2022 Apr 23.

Urology Surgery (Andrology), The First Hospital of Qinhuangdao, Qinhuangdao, 066000 Hebei, China.

Chronic prostatitis is a very common and very difficult disease. Based on the mobile medical system, this paper carried out a correlation analysis on the psychological factors and the evaluation of premature ejaculation in patients with benign prostatic hyperplasia. The article first analyzes the application in the field of mobile medical and then introduces the prostate image segmentation method based on the geometric active contour model. Read More

Asian J Androl 2022 Apr 22. Epub 2022 Apr 22.

Department of Andrology, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing 210008, China.

Selective dorsal neurotomy (SDN) is a surgical treatment for primary premature ejaculation (PE), but there is still no standard surgical procedure for selecting the branches of the dorsal penile nerves to be removed. We performed this study to explore the value of intraoperative neurophysiological monitoring (IONM) of the penile sensory-evoked potential (PSEP) for standard surgical procedures in SDN. One hundred and twenty primary PE patients undergoing SDN were selected as the PE group and 120 non-PE patients were selected as the normal group. Read More

Prim Care Companion CNS Disord 2022 Apr 21;24(2). Epub 2022 Apr 21.

Kozhikkode Medical College, Kozhikkode, Kerala, India.

Adv Clin Exp Med 2022 Apr 19. Epub 2022 Apr 19.

2nd Department of Urology, Second Affiliated Hospital of Harbin Medical University, China.

Background: The use of selective dorsal neurectomy (SDN) as a surgical treatment of premature ejaculation (PE) has increased for many years in Asian countries.

Objectives: To investigate the correlation between age and curative effects of SDN in primary premature ejaculation (PPE) in mainland China.

Material And Methods: From September 2016 to September 2020, 65 patients with PPE treated with SDN were selected for study. Read More

Biomed Res Int 2022 8;2022:8049976. Epub 2022 Apr 8.

Department of Urology and Andrology, The First Affiliated Hospital of Anhui Medical University, Anhui Province, China.

Although the personality traits (PT), patient-reported outcome (PRO), and chronic prostatitis (CP) symptoms in premature ejaculation (PE) have been evaluated, there was no study to assess their correlations in men with different PE syndromes. The purpose of this study was to assess the correlations between the PT, PRO, and CP symptoms in men with different PE syndromes. Between January 2019 and January 2021, a cross-sectional field study was conducted in our andrology clinic. Read More

Sex Med 2022 Jun 7;10(3):100509. Epub 2022 Apr 7.

Department of Urology, Hospital of Anhui Medical University, Anhui province, China; Institute of Urology, Hospital of Anhui Medical University, Anhui province, China; Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Anhui province, China. Electronic address:

Background: Leptin, which was only discovered in humans in 1994, has recently been shown to have a possible link with premature ejaculation.

Aim: To evaluate whether serum leptin levels differed between patients with premature ejaculation and healthy men, and to analyze the changes in leptin levels before and after treatment.

Methods: Six studies assessing the relationship between leptin and premature ejaculation published up to October 2021 were identified from multiple databases (PubMed, Web of Science, Cochrane) and the data were analyzed by Stata software. Read More

Asian J Androl 2022 Apr 5. Epub 2022 Apr 5.

Department of Urology, European Institute of Oncology, IRCCS, Milan 20141, Italy.

Sexual disorders following retroperitoneal pelvic lymph node dissection (RPLND) for testis tumor can affect the quality of life of patients. The aim of the current study was to investigate several different andrological outcomes, which may be influenced by robot-assisted (RA) RPLND. From January 2012 to March 2020, 32 patients underwent RA-RPLND for stage I nonseminomatous testis cancer or postchemotherapy (PC) residual mass. Read More

Sex Med 2022 Jun 1;10(3):100506. Epub 2022 Apr 1.

Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: The reliability of the International Index of Erectile Function (IIEF-5) in diagnosing erectile dysfunction (ED) is significantly decreased for the population with premature ejaculation (PE).

Aim: We aimed to illustrate a better way of diagnosing ED among the general population through a web survey study.

Methods: We collected online surveys from 2,746 men between the ages of 18 and 65. Read More

J Healthc Eng 2022 22;2022:8331688. Epub 2022 Mar 22.

The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang, China.

Objective: To investigate the clinical efficacy and possible mechanism of electroacupuncture in the treatment of premature ejaculation.

Methods: 50 cases of premature ejaculation patients who met the diagnostic criteria were randomly divided into 2 groups with 25 cases in each group. The observation group was treated with electroacupuncture, and the control group was treated with Longdan Xiegan decoction. Read More

Arch Ital Urol Androl 2022 Mar 29;94(1):80-86. Epub 2022 Mar 29.

Aydin Adnan Menderes University School of Medicine, Department of Urology, Aydin.

Purpose: To evaluate the clinical characteristics of men presenting for other complaints whose ejaculatory function inquiry indicated premature ejaculation (PE).

Methods: The data of 536 PE patients, including those who presented with the complaint of PE (group 1) and those presenting with other complaints who were diagnosed with PE (group 2) as a result of ejaculatory function inquiry using estimated intravaginal ejaculation latency time (IELT) and Premature Ejaculation Diagnostic Tool (PEDT), were retrospectively evaluated. Age, PE type, comorbidities, recommended treatments, and treatment acceptance status of all patients were recorded. Read More

Andrologia 2022 Mar 24:e14425. Epub 2022 Mar 24.

Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

To assess dapoxetine discontinuation rates and the reasons for discontinuation in Chinese men with premature ejaculation (PE). Information on 906 PE outpatients was obtained from the hospital information system (HIS) in 2019. Of these, 150 patients were chosen. Read More

Int J Impot Res 2022 Mar 21. Epub 2022 Mar 21.

Department of Urology, University of Naples, Federico II, Naples, Italy.

A eutectic mixture of prilocaine/lidocaine spray (Fortacin™, Recordati, Milan, Italy) has been approved for the management of patients affected by life-long premature ejaculation (PE), but to date, there is a lack of dose- or time-finding studies in the literature that indicate the best method of intake to optimize treatment outcomes. In this multicentre, randomized, two-phase study, we aimed to compare, in terms of treatment effectiveness (primary objective) and safety (secondary objective), different treatment regimens (various doses and times of drug delivery) of Fortacin™ in 91 patients affected with lifelong PE who were recruited at four different centres and randomized (1:1:1 ratio) into three different groups. The study included two phases: during the first phase (focused on time-finding), the same drug dose (three sprays) was taken at different intervals before intercourse (5, 15, 30 min). Read More

Front Physiol 2022 28;13:762272. Epub 2022 Feb 28.

Department of Urology and Andrology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Ejaculation is a complex biphasic process involving a series of neurophysiological activities, such as the contraction of a large number of muscle groups and the ejaculation of semen from the urethra anterior. Due to the complexity of the process, many related factors have not been fully clarified, resulting in ejaculation dysfunction. As a common ejaculation dysfunction, lifelong premature ejaculation (LPE) is a problem for many people. Read More

Transl Androl Urol 2022 Feb;11(2):253-259

Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: This study aimed to evaluate the efficacy of thickened condoms in the treatment of premature ejaculation.

Methods: From August to December 2021, patients with premature ejaculation treated in the Urology and Andrology Center of the First Affiliated Hospital of Medical College of Zhejiang University were selected for a clinical controlled study. A total of 100 patients with premature ejaculation were enrolled as the premature ejaculation group and 30 normal men as the control (normal married men, age <30 years, normal sexual life). Read More