1,655 results match your criteria Premature Ejaculation


Sexual Dysfunction among Men in Rural Tamil Nadu: Nature, Prevalence, Clinical Features, and Explanatory Models.

Indian J Psychol Med 2019 Jan-Feb;41(1):81-86

Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India.

Background And Aim: There is a dearth of community data on nature, prevalence, clinical features, and explanatory models related to sexual dysfunction among men, particularly from rural India. This study attempted to examine different aspects of male sexual dysfunction and misconceptions in the community.

Materials And Methods: Villages in Kaniyambadi Block, Vellore district were stratified, and four were randomly selected. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_153_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337923PMC
February 2019

The Penile Sensitivity Ratio: A Novel Application of Biothesiometry to Assess Changes in Penile Sensitivity.

J Sex Med 2019 Feb 14. Epub 2019 Feb 14.

Division of Urology, Rush University Medical Center, Chicago, IL, USA.

Introduction: Biothesiometry allows for evaluation of penile vibratory sensitivity and can be used as a non-invasive and rapid surrogate test of penile sexual sensitivity. However, no standardized measurement methodology currently exists.

Aim: To describe and optimize a novel, standardized biothesiometry parameter-the penile sensitivity ratio (PSR). Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.01.002DOI Listing
February 2019

Effectiveness and safety of fluoxetine for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2019 Feb;98(7):e14481

Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men's self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men's health has gained more and more attention. Read More

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http://Insights.ovid.com/crossref?an=00005792-201902150-0004
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http://dx.doi.org/10.1097/MD.0000000000014481DOI Listing
February 2019
4 Reads

Which psychosocial variables affect drive the most? Analysis of sexual desire in a group of Italian men.

Int J Impot Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Via dei Marsi 78, 00185, Rome, Italy.

Literature lacks wide studies on variables affecting sexual desire in men. Aim of this study was to explore the role of some psychosocial variables such as quality of life, sexual function, distress, sexual satisfaction, psychological symptoms, emotions, alexithymia, couple adjustment, sexism, dysfunctional beliefs, cognitive schemas, and modes. A self-administered survey reached 450 heterosexual Italian men (age 31. Read More

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http://dx.doi.org/10.1038/s41443-018-0105-8DOI Listing
February 2019
1 Read

Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study.

Int J Impot Res 2019 Jan 31. Epub 2019 Jan 31.

Bahceci Health Group, Department of Urology, Istanbul, Turkey.

Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE. Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there are limited data about the efficacy and safety of dapoxetine/sildenafil combination therapy for these patients. Read More

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http://www.nature.com/articles/s41443-019-0122-2
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http://dx.doi.org/10.1038/s41443-019-0122-2DOI Listing
January 2019
12 Reads

Effectiveness comparisons of acupuncture for premature ejaculation: Protocol for a network meta-analysis.

Medicine (Baltimore) 2019 Feb;98(5):e14147

Chinese Medicine Hospital, Changping District, Beijing, China.

Background: As one of the common male sexual dysfunction diseases, the treatment effect of premature ejaculation is often difficult to guarantee. In China, there are many randomized clinical trials that confirm that acupuncture has a good therapeutic effect on premature ejaculation. The aim of this study was to compare the efficacy and safety of acupuncture for premature ejaculation from intravaginal ejaculation latency (IELT), premature ejaculation diagnostic tool (PEDT), Arab premature ejaculation index (AIPE), and premature ejaculation index (IPE). Read More

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http://dx.doi.org/10.1097/MD.0000000000014147DOI Listing
February 2019
3 Reads

[Andrology - Whom and how are patients being referred?]

Rev Int Androl 2019 Jan - Mar;17(1):31-36. Epub 2018 Mar 19.

Serviço de Urologia, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal.

Introduction: Andrology focuses in male sexual and fertility diseases. Its referral should be thoughtful and tailored in order to select the correct cases.

Objectives: The aim of this work was to evaluate the referral to our department and improvement points. Read More

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http://dx.doi.org/10.1016/j.androl.2017.12.002DOI Listing
March 2018
1 Read

Differences between ICD-11 MMS and DSM-5 definition of premature ejaculation: a continuation of historical inadequacies and a source of serious misinterpretation by some European Regulatory Agencies (PART 2).

Int J Impot Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Gasthuis, Delft, The Netherlands.

Recently, the ICD-11 for Mortality and Morbidity Statistics (ICD-11-MMS, 2018 Version) has been published with a new definition of premature ejaculation (PE), including a third PE subtype. This definition differs from Diagnostic and Statistical Manual of Mental Disorders (DSM-5) definition of PE. We hereby address the similarities and differences between ICD-11-MMS and DSM-5 definition of PE and call attention to the illogical policy of some European (EU) National Regulatory Agencies to remain with a 1-min cut-off point of ejaculation time for Lifelong, Acquired and Subjective PE. Read More

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http://dx.doi.org/10.1038/s41443-018-0108-5DOI Listing
January 2019
2 Reads

Surgical treatment for primary premature ejaculation with an inner condom technique.

Medicine (Baltimore) 2019 Jan;98(3):e14109

Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China.

To explore a novel surgical treatment for primary premature ejaculation using an inner condom technique.A total of 20 males with premature ejaculation, who admitted our andrology clinic from June 2016 to July 2017, were enrolled. By surgery, an inner condom made of acellular dermal matrix (ADM) was transferred to the subcutaneous pocket of the penis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014109DOI Listing
January 2019
7 Reads

Efficacy and safety of behavioral therapy for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2019 Jan;98(3):e14056

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine.

Background: Premature ejaculation (PE) is the one of the most prevalent male sexual dysfunction, there has not been specific medicine or therapy for the disease. As an effective treatment for premature ejaculation is a behavioral therapy and is widely used worldwide. The purpose of this study is to evaluate the efficacy and safety of behavioral therapy in patients who suffer from PE. Read More

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http://dx.doi.org/10.1097/MD.0000000000014056DOI Listing
January 2019
2 Reads

Method and design of drug treatment research of subjective premature ejaculation in men differs from that of lifelong premature ejaculation in males: proposal for a new objective measure (part 1).

Int J Impot Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Gasthuis, Delft, The Netherlands.

As lifelong premature ejaculation (PE) and subjective PE are two different PE subtypes, the measurement of their characteristic features requires different objective measures. In this article, we address the differences between lifelong PE and subjective PE, in terms of the extent of variation of sexual performance and propose a new objective measure for research of subjective PE. By considering lifelong PE as a mainly "male" sex disorder and subjective PE as a mainly "man" sex disorder, we show that stopwatch-mediated intravaginal ejaculation latency time (IELT) measurement is most adequate for research of lifelong PE, but inadequate for research of subjective PE. Read More

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http://www.nature.com/articles/s41443-018-0107-6
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http://dx.doi.org/10.1038/s41443-018-0107-6DOI Listing
January 2019
3 Reads

Pharmacokinetics, Safety, and Tolerability of Multiple Doses of the Novel Oxytocin Receptor Antagonist Cligosiban in Development for Premature Ejaculation: Two Randomized Clinical Trials in Healthy Subjects.

J Sex Med 2019 Feb 4;16(2):213-222. Epub 2019 Jan 4.

Hammersmith Medicines Research Ltd, London, UK.

Background: Cligosiban (formerly IX-01) is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE).

Aim: To investigate the plasma pharmacokinetics, safety, and tolerability of multiple oral doses of cligosiban in healthy male subjects; measure the amount of cligosiban in semen; and evaluate the potential of cligosiban to modulate CYP3A4.

Methods: Both studies were double-blind, placebo-controlled, parallel group designs involving sequential cohorts of 12 subjects each. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.11.012DOI Listing
February 2019
9 Reads

Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study.

Int J Impot Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.

This randomized controlled cross-over study aimed to assess the efficacy and safety of glans penis injection with hyaluronic acid (HA) in treating premature ejaculation (PE). A total of 30 patients with PE were randomly allocated into two groups: group 1 (n = 15) which was subjected to glans penis HA injection and group 2 (n = 15) which was injected with saline as a control then both groups were subjected to follow-up at 1 week and 1 month after injection. These subjects were evaluated by intra-vaginal ejaculation latency time (IELT) and the Arabic validated index of premature ejaculation (AIPE). Read More

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http://dx.doi.org/10.1038/s41443-018-0104-9DOI Listing
January 2019
2 Reads

Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis.

BMC Urol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Urology & Nephrology, Ningbo First Hospital, The affiliated hospital of ZheJiang University, 59, Liuting Street, Ningbo, Zhejiang, China.

Background: Paroxetine is one of the selective serotonin reuptake inhibitors (SSRIs) used in the treatment of premature ejaculation (PE). However, this use is not approved in many countries. The purpose of this systematic review and meta-analysis is to review the efficacy and safety of paroxetine for PE patients. Read More

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http://dx.doi.org/10.1186/s12894-018-0431-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318994PMC
January 2019
9 Reads

Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation.

World J Mens Health 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.

Materials And Methods: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Read More

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https://wjmh.org/DOIx.php?id=10.5534/wjmh.180062
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http://dx.doi.org/10.5534/wjmh.180062DOI Listing
December 2018
9 Reads

Changes in the Prevalence and Risk Factors of Erectile Dysfunction during a Decade: The Korean Internet Sexuality Survey (KISS), a 10-Year-Interval Web-Based Survey.

World J Mens Health 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.

Purpose: Although the prevalence of erectile dysfunction (ED) can be affected by social changes, this association has not been well evaluated. We aimed to evaluate the prevalence and risk factors of ED through a 10-year-interval web-based survey using the previous database of same group of panels, with same methodology.

Materials And Methods: We sent e-mails and surveyed the panels registered in the Internet survey agency. Read More

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http://dx.doi.org/10.5534/wjmh.180054DOI Listing
December 2018
2 Reads

Correlation between premature ejaculation and psychological disorders in 270 Chinese outpatients.

Psychiatry Res 2018 Dec 6;272:69-72. Epub 2018 Dec 6.

Department of Sexual Medicine, Affiliated Yijishan Hospital of Wannan Medical College.

Clinical patients with premature ejaculation(PE) often present with poor psychological state. This study investigated whether there is a difference in the psychological state of PE and non-PE in outpatients, and whether there is a correlation between ejaculatory latency and psychological disorders. We studied demographics informations and psychological indicators for PE patients and control group, including the Self-Rating Anxiety Scale(SAS) and Self-Rating Depression Scale(SDS), Pittsburgh Sleep Quality Index (PSQI) and recorded the ejaculatory latency. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.12.038DOI Listing
December 2018
1 Read

Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross-sectional study.

Andrology 2018 Dec 16. Epub 2018 Dec 16.

Sexual Medicine and Andrology Unit, Department of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.

Background: Premature ejaculation (PE) is present in up to 30% of men with erectile dysfunction (ED).

Objectives: To assess the clinical features of men complaining of both ED and PE (ED-PE) as compared to men reporting only ED or PE.

Materials And Methods: A consecutive series of 4024 men (mean age 51. Read More

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http://dx.doi.org/10.1111/andr.12579DOI Listing
December 2018
2 Reads

Comparative efficacy and safety of phosphodiesterase-5 inhibitors with selective serotonin reuptake inhibitors in men with premature ejaculation: A systematic review and Bayesian network meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13342

Department of Urology, Institute of Urology, West China Hospital of Sichuan University.

Background: We performed the network meta-analysis (NMA) and systematic review involved all evidence from relevant trials to compare the efficiency and safety of various types of selective serotonin reuptake inhibitors (SSRI) and phosphodiesterase-5 inhibitors (PDE5i) in patients with premature ejaculation (PE).

Methods: We conducted comprehensive searches of peer-reviewed and grey literature. PubMed, the Cochrane Library Central Register of Controlled Trials, Embase were searched for randomized controlled trials published up to June 1, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310608PMC
December 2018
2 Reads

Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents.

J Sex Med 2018 Dec;15(12):1698-1706

Pfizer Global Research and Development, Sexual Health Therapeutic Area, Sandwich, United Kingdom; Ixchelsis Ltd, Sandwich, United Kingdom. Electronic address:

Introduction: Few treatments are available for men with premature ejaculation (PE); oxytocin (OT) receptor antagonism in the central nervous system (CNS) is a potential new approach.

Aim: To determine if cligosiban selectively inhibits human OT receptors, penetrates the CNS, shows pharmacology in the CNS, and effects ejaculatory physiology in pre-clinical systems.

Methods: Experiments complied with United Kingdom legislation and were subject to local ethical review. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.10.008DOI Listing
December 2018
2 Reads

Psychological burden prediction based on demographic variables among infertile men with sexual dysfunction.

Asian J Androl 2018 Nov 20. Epub 2018 Nov 20.

Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

There has been increasing interest in the psycho-socio-relational and sexual disorders of infertility, as the risk of psychological burden among infertile men with sexual dysfunctions is significant. The purpose of this study was to develop and to validate a predictive model to estimate individual psychological burden among infertile men with sexual dysfunction and study the association between them. Comprehensive data were collected for infertile men (n = 480) who sought treatment for infertility in a reproductive medicine center between June 2012 and December 2013. Read More

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http://dx.doi.org/10.4103/aja.aja_86_18DOI Listing
November 2018
10 Reads

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women.

Sex Med Rev 2018 Nov 17. Epub 2018 Nov 17.

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Introduction: Sexual dysfunction affects many people, with 33‒60% of women reporting sexual dysfunction and 8‒52% of men with erectile dysfunction or premature ejaculation. In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest.

Aim: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.09.005DOI Listing
November 2018
10 Reads

Premature ejaculation in primary care: communication strategies versus usual care for male patients consulting for a sexual, urogenital or psychological reason - GET UP: study protocol for a cluster randomised controlled trial.

Trials 2018 Nov 12;19(1):622. Epub 2018 Nov 12.

Département de Médecine Générale, UFR Sciences Médicales, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux cedex, France.

Background: Premature ejaculation (PE) is the most common sexual dysfunction among men. According to patients, the general practitioner (GP) is the appropriate professional with whom to discuss this issue. However, few patients receive the medical help needed because GPs find it difficult to talk to their patients about sex. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-018-2947-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233366PMC
November 2018
9 Reads

Acellular dermal matrix in premature ejaculation: A preliminary study.

Medicine (Baltimore) 2018 Nov;97(45):e13135

Department of Urology, Peking University People's Hospital.

Background: To investigate the efficacy of acellular dermal matrix in penis augmentation (ADMPA) for premature ejaculation (PE).

Methods: A total of 39 patients treated with ADM in penis augmentation from June 2014 to December 2017 were evaluated. Detailed evaluations on PE were conducted before operation and at the 6-month and 2-year follow-up visits after operation. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0006
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http://dx.doi.org/10.1097/MD.0000000000013135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250443PMC
November 2018
11 Reads

The antioxidant compounds isolated from the fruits of chinese wild raspberry Rubus Chingii Hu.

Nat Prod Res 2018 Oct 22:1-4. Epub 2018 Oct 22.

a Department of Applied Chemistry , Xi'an University of Technology , Xi'an , China.

Raspberry, the fruit of Rubus Chingji Hu, is a widely distributed economic staple food in China. It has long been used as a traditional medicine in mainland China to treat kidney enuresis, nocturnal emission and premature ejaculation in clinic. In this paper, six known compounds (1 - 6) were purified from the fruits of Rubus chingji. Read More

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http://dx.doi.org/10.1080/14786419.2018.1504046DOI Listing
October 2018
13 Reads

Pharmacokinetics, Safety, and Tolerability of Single Oral Doses of a Novel Oxytocin Receptor Antagonist-Cligosiban-in Development for Premature Ejaculation: Three Randomized Clinical Trials in Healthy Subjects.

J Sex Med 2018 Nov 16;15(11):1547-1557. Epub 2018 Oct 16.

Worldwide Clinical Trials, Early Phase Services LLC, San Antonio, Texas, USA.

Introduction: Cligosiban is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE).

Aim: Three clinical studies investigated the pharmacokinetics (including effect of food and formulation), central penetration, safety, and tolerability of single oral doses of cligosiban in healthy subjects.

Methods: Study 1 was a double-blind, randomized, placebo-controlled, crossover design in 3 cohorts of 10 subjects each. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17436095183116
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http://dx.doi.org/10.1016/j.jsxm.2018.09.006DOI Listing
November 2018
7 Reads

Milnacipran for Postcoital Cephalgia and Premature Ejaculation.

Authors:
Ahmed Naguy

Am J Ther 2018 Sep 25. Epub 2018 Sep 25.

Al-Manara Centre, Kuwait Centre for Mental Health (KCMH), Kuwait City, Kuwait.

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http://Insights.ovid.com/crossref?an=00045391-900000000-9855
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http://dx.doi.org/10.1097/MJT.0000000000000863DOI Listing
September 2018
9 Reads
1.130 Impact Factor

[Effects of drug use and anxiety on premature ejaculation in a sample of Spanish drug addicts].

Rev Int Androl 2018 Oct - Dec;16(4):159-166. Epub 2018 Mar 30.

Departamento de Fisiología, Facultad de de la Actividad Física y del Deporte, Universidad de Granada, Granada, España.

Introduction: Premature ejaculation may be due to many factors and one of them may be drug use.

Aims: The main objective of this study is to show how drug abuse affects the ejaculatory response, keeping in mind the different substances consumed, the level of anxiety and the period of withdrawal.

Method: Two samples were used, one for men who were addicted to drugs (N=925) and one of non-consumers (N=82). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1698031X183002
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http://dx.doi.org/10.1016/j.androl.2017.09.004DOI Listing
March 2018
6 Reads

Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis.

Ann Saudi Med 2018 Sep-Oct;38(5):366-375

Dr. Jing Li, Department of Urology,, Xinxiang Central Hospital,, Xinxiang 453000, China, T: +8613462286403, ORCID: http:// orcid.org/0000-0003-3030-354X.

Background: The safety and efficacy of dapoxetine for the treatment of premature ejaculation (PE) is still controversial. Thus, we decided to conduct a meta-analysis using trial sequential analysis (TSA) to determine the sufficiency of conclusions.

Objective: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the findings. Read More

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http://dx.doi.org/10.5144/0256-4947.2018.366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180218PMC
January 2019
4 Reads

5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation.

Rev Int Androl 2018 Sep 25. Epub 2018 Sep 25.

Andrology & STDs Department, Cairo University, Egypt.

Introduction And Objectives: Lifelong premature ejaculation (LPE) is identified as the inability to delay ejaculation for more than 1min after vaginal penetration occurring on all or almost all sexual experiences together with feelings of frustration of both the patient and his partner with avoidance of sexual intimacy. Recently, a role for (HTR1A)-C (1019) G gene polymorphism in patients with LPE was postulated.

Materials And Methods: Three hundred and fifty participants were prospectively enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.androl.2018.07.004DOI Listing
September 2018
4 Reads

The Relationship Between Body Image and Sexual Functioning Among Gay and Bisexual Men.

J Homosex 2018 Sep 28:1-26. Epub 2018 Sep 28.

b Department of Family Relations and Applied Nutrition , The University of Guelph, Guelph , Ontario , Canada.

Gay and bisexual men report high body dissatisfaction compared to heterosexual counterparts, but no studies to date have examined how this may impact their sexual functioning. The present study investigated body image domains as predictors of sexual functioning problems (inhibited desire, erectile dysfunction, and premature ejaculation) among an online community sample of 185 gay and bisexual men, ages 18-40. Participants reported moderate to high body image satisfaction and sexual functioning consistent with previous literature with nonclinical male samples. Read More

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http://dx.doi.org/10.1080/00918369.2018.1519301DOI Listing
September 2018
2 Reads

Editorial to the paper entitled "pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis".

Authors:
Ali Atan

Int Urol Nephrol 2018 Nov 21;50(11):2015-2016. Epub 2018 Sep 21.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

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http://link.springer.com/10.1007/s11255-018-1988-5
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http://dx.doi.org/10.1007/s11255-018-1988-5DOI Listing
November 2018
7 Reads

Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis.

Int Urol Nephrol 2018 Nov 17;50(11):1939-1948. Epub 2018 Sep 17.

Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Purpose: The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for premature ejaculation (PE).

Methods: A systematic literature search of MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for Systematic Reviews was performed on 1 March 2018. Intravaginal ejaculation latency time (IELT) was the main outcome. Read More

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http://link.springer.com/10.1007/s11255-018-1984-9
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http://dx.doi.org/10.1007/s11255-018-1984-9DOI Listing
November 2018
15 Reads

Abnormal White Matter Microstructure in Lifelong Premature Ejaculation Patients Identified by Tract-Based Spatial Statistical Analysis.

J Sex Med 2018 Sep;15(9):1272-1279

Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address:

Introduction: Several recent neuroimaging studies have identified functional and structural abnormalities in the cerebral cortex of lifelong premature ejaculation (LPE) patients, including task-related and resting-state brain function, and cortical thickness, although changes in white matter microstructure have not been reported.

Aim: To assess the differences in white matter microstructure between LPE patients and healthy controls.

Methods: Diffusion tensor imaging (DTI) and tract-based spatial statistical analysis were used to detect differences in white matter microstructure between 32 LPE patients and 32 matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.07.012DOI Listing
September 2018
18 Reads

[Qiaoshao Prescription improves premature ejaculation in male rats by increasing the content of 5-hydroxytryptamine].

Zhonghua Nan Ke Xue 2018 08;24(8):724-728

Department of Andrology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China.

Objective: To observe the intervention effect of Qiaoshao Prescription (QSP) on premature ejaculation (PE) induced by 8-OH-DPAT in male rats and explore its possible action mechanism.

Methods: Seventy-two male Wistar rats were equally randomized into six groups, blank control, PE model control, low-, medium- and high-dose QSP, and dapoxetine. The PE model was established by injection of 8-OH-DPAT into the subarachnoid space of the lumbosacral spinal cord. Read More

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August 2018
13 Reads

[Injection of botulinum-A toxin into bulbospongiosus muscle for primary premature ejaculation: A preliminary clinical study].

Zhonghua Nan Ke Xue 2018 Aug;24(8):713-718

Department of Urology, Research Institute of Field Surgery, The Third Affiliated Hospital of Army Medical University, Chongqing 400042, China.

Objective: To evaluate the efficacy and safety of injection of botulinum-A toxin into the bulbospongiosus muscle in the treatment of primary premature ejaculation (PPE).

Methods: According to the inclusion criteria, we randomly assigned 70 outpatients with PPE to a trial and a control group of equal number, the former injected with 100 U botulinum-A toxin at 10 U/ml and the latter with the same volume of saline into the bulbospongiosus muscle. Then, we obtained the intravaginal ejaculatory latency time (IELT), scores of the Premature Ejaculation Profile (PEP), Male Sexual Health Questionnaire-Ejaculatory Dysfunction (MSHQ-EjD), and Hospital Anxiety and Depression Scale (HADS), and the incidence of adverse reactions between the two groups before and 4 weeks after treatment. Read More

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August 2018
16 Reads

Acupuncture for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2018 Aug;97(35):e11980

Department of Andrology, Dongzhimen Hospital, Beijing, China.

Background: Premature ejaculation is a common sexual dysfunction disease in adult males. It can be divided into primary and secondary premature ejaculation. Acupuncture is widely used in the treatment of premature ejaculation in China. Read More

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http://dx.doi.org/10.1097/MD.0000000000011980DOI Listing
August 2018
38 Reads

[Advances in the surgical treatment of premature ejaculation].

Zhonghua Nan Ke Xue 2018 Apr;24(4):364-369

Department of Andrology, Nanjing Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.

Premature ejaculation (PE) is a most common type of ejaculatory dysfunction, which has significant adverse effects on the life quality of the patients and their partners. Medication is currently the first choice for PE and psycho-behavior therapy is sometimes used as an adjuvant means. It is reported in a number of studies that medication alone or combined with psycho-behavior therapy has a great short-term efficacy and a very low risk of side effects. Read More

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April 2018
3 Reads

[Correlation of 5-hydroxytryptamine transporter gene-linked polymorphic region with lifelong premature ejaculation: Progress in studies].

Zhonghua Nan Ke Xue 2018 Mar;24(3):268-271

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.

Premature ejaculation (PE), as one of the most common male sexual dysfunctions, has a serious negative impact on the sexual satisfaction of the patients and their sexual partners. Lifelong PE is a most common type and a current focus of research as well. The etiology and pathogenesis of this disease are not yet clear and genetic factors are considered to be closely related to lifelong PE. Read More

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March 2018
2 Reads

[Establishment of a rat model of premature ejaculation with 8-OH-DPAT].

Zhonghua Nan Ke Xue 2018 Feb;24(2):104-108

Department of Andrology, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, China.

Objective: To explore the feasibility and practicability of establishing a rat model of premature ejaculation (PE) by injection of 8-OH-DPAT into the subarachnoid space of the lumbosacral spinal cord segments.

Methods: Twenty-four male Wistar rats were equally randomized into a PE model and a blank control group. The PE model was established by injection of 8-OH-DPAT in 10 ml normal saline at 0. Read More

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February 2018
26 Reads

Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study.

Int Urol Nephrol 2018 Nov 28;50(11):1975-1980. Epub 2018 Aug 28.

Urology Department, Kasr Alainy Faculty of Medicine, Kasr Al-Ainy Hospitals, Cairo University, Cairo, Egypt.

Purpose: To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls.

Methods: Healthy married potent males were recruited from February 2017 to January 2018. Group A included 40 patients suffering from LPE who were compared versus 40 healthy controls (Group B). Read More

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http://dx.doi.org/10.1007/s11255-018-1975-xDOI Listing
November 2018
4 Reads

General and sex profile of women with partner affected by premature ejaculation: results of a large observational, non-interventional, cross-sectional, epidemiological study (IPER-F).

Andrology 2018 Sep 17;6(5):714-719. Epub 2018 Aug 17.

Department of Neurosciences, Sciences of Reproduction and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.

Background: Couple distress is a crucial point in premature ejaculation (PE). PE has been associated with significant bother, interpersonal problems, and dissatisfaction with sexual intercourse for both men and their partners.

Objectives: The primary objective of this study was to assess the effect of PE on female sexuality in female partners of men affected from PE. Read More

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http://dx.doi.org/10.1111/andr.12545DOI Listing
September 2018
2 Reads

Prevalence and correlates of sexual health disorders among adult men in a rural area of North India: An observational study.

J Family Med Prim Care 2018 May-Jun;7(3):515-521

Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background And Objectives: Sexual health disorders are an important but less researched public health issue in India. We aimed to estimate the prevalence of sexual health disorders and their associated factors among adult men in a rural community of Haryana, India.

Materials And Methods: A community-based cross-sectional study was conducted among adult men aged 18-60 years using a multistage stratified random sampling. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_348_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069647PMC
August 2018
3 Reads

Efficacy and Safety of On Demand Clomipramine for the Treatment of Premature Ejaculation: A Multicenter, Randomized, Double-Blind, Phase III Clinical Trial.

J Urol 2019 Jan;201(1):147-152

Department of Urology, Catholic University of Korea, Seoul, Republic of Korea.

Purpose: The aim of the current trial was to assess the efficacy of on demand clomipramine 15 mg administered before sexual intercourse for the treatment of premature ejaculation.

Materials And Methods: A total of 159 patients at 5 centers in Korea were randomly assigned to 2 groups. The first group of 53 men received placebo and the second group of 106 received clomipramine 15 mg for 12 weeks. Read More

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http://dx.doi.org/10.1016/j.juro.2018.07.089DOI Listing
January 2019
12 Reads

Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation.

Sex Med 2018 Dec 2;6(4):297-301. Epub 2018 Aug 2.

Department of Urology, Korea University College of Medicine, Seoul, Korea. Electronic address:

Introduction: Glans penis augmentation (GPA) using hyaluronic acid (HA) gel has been developed for treating premature ejaculation (PE) with penile hypersensitivity. The injected HA filler creates a barrier that reduces the tactile stimuli to the hypersensitive dorsal nerve. Although the HA filler is biodegradable and is believed to not cause permanent loss of sexual function, the current International Society for Sexual Medicine guideline for PE does not recommend this procedure owing to concerns regarding sexual dysfunction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20501161183005
Publisher Site
http://dx.doi.org/10.1016/j.esxm.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302150PMC
December 2018
12 Reads

Assessment of Dyadic Adjustment and Sexual Functions in Patients with Bipolar Disorder.

Noro Psikiyatr Ars 2018 2;55(2):171-176. Epub 2018 May 2.

Department of Psychiatry, Çukurova University Medical Faculty, Adana, Turkey.

Introduciton: There are limited studies investigating the relation between dyadic adjustment, and sexual functions. The aim of this study was to compare patients with bipolar disorder (BD) in euthymic phase with healthy controls, and confirm our hypothesis which we expect to find that dyadic adjustment is negatively affected in bipolar patients with sexual dysfunctions (SDs).

Methods: A total of 50 euthymic bipolar patients (32 female, 18 male), and 50 healthy individuals as a control group (27 female, 23 male) were included in the study. Read More

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http://dx.doi.org/10.5152/npa.2017.19213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060662PMC
May 2018
17 Reads

Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review.

Sex Med Rev 2019 01 26;7(1):129-140. Epub 2018 Jul 26.

European Institute for Sexual Health (EISH), Hamburg, Germany.

Introduction: Besides erectile dysfunction, premature ejaculation (PE) is the most frequent male sexual disorder and shows a high level of bother and distress. The negative consequences of long-term and unsuccessfully treated PE on both patient and partner are well established in the literature and include personal distress, impairment of the partner's sexual function, and interpersonal difficulties.

Aim: To outline the consequences of untreated PE and the advantages and disadvantages of currently available treatment options with a special focus on a new topical eutectic lidocaine/prilocaine metered dose spray (Fortacin; Lidocaine/Prilocaine, Recordati, Milan, Italy) which represents the second officially approved drug in this indication. Read More

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http://dx.doi.org/10.1016/j.sxmr.2018.05.001DOI Listing
January 2019
8 Reads

Fortacin™ Spray for the Treatment of Premature Ejaculation.

Urologia 2017 Dec;84(2_suppl):1-10

Private Institute for Urology, Andrology and Sexual Medicine, Hamburg - Germany.

Premature ejaculation (PE) is a common complaint of male sexual dysfunction affecting men and their partners and consequently causing significant personal and interpersonal distress. Increased sensitivity of the glans penis and abnormalities of the afferent-efferent reflex pathway within the ejaculatory process are involved in the occurrence of PE. Drugs that either selectively reduce penile sensitization or modify the afferent-efferent reflex are well established therapeutic options for PE. Read More

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http://dx.doi.org/10.5301/uj.5000275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166492PMC
December 2017