1,814 results match your criteria Premature Ejaculation


Trends in reported male sexual dysfunction over the past decade: an evolving landscape.

Int J Impot Res 2020 Jul 1. Epub 2020 Jul 1.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

We investigated changes in patterns of reported male SDs at a single academic centre over a 10-year time frame. Comprehensive data of 2013 patients consecutively assessed for the first time by a single Sexual Medicine expert between 2006 and 2019 has been analysed. All patients were assessed with a thorough sexual and medical history. Read More

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http://dx.doi.org/10.1038/s41443-020-0324-7DOI Listing

Impact of Childhood Sexual Assault on Sexual Function in the Czech Male Population.

Sex Med 2020 Jun 24. Epub 2020 Jun 24.

Institute of Sexology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Introduction: This study explores the impact of childhood sexual assault (CSA) on men's sexual function. There is limited understanding on the impact of CSA perpetrated against boys on later adult male sexual function, as there is a dearth of research on this topic. It was hypothesized that men reporting a history of CSA were more likely to report sexual function issues than men with no history of CSA. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.06.003DOI Listing

Smartphone-Based Therapeutic Exercises for Men Affected by Premature Ejaculation: A Pilot Study.

Sex Med 2020 Jun 18. Epub 2020 Jun 18.

Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.

Introduction: Smartphone-delivered healthcare interventions allow patients to access services on demand when needed, improving motivation and compliance. However, the use of mobile health apps has been scarcely explored in sexual medicine.

Aim: To evaluate the effects of integrating psychological treatment for premature ejaculation (PE) with a mobile coaching app that offers therapeutic exercises on the patient's smartphone. Read More

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http://dx.doi.org/10.1016/j.esxm.2020.05.003DOI Listing

Striatum-related Intrinsic Connectivity Deficits in Lifelong Premature Ejaculation Patients.

Urology 2020 Jun 13. Epub 2020 Jun 13.

Life Science Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China. Electronic address:

Objectives: To investigate abnormal intrinsic connectivity of striatum in lifelong premature ejaculation (PE) patients compared with healthy controls (HCs) METHODS: : Forty-seven lifelong PE patients and thirty healthy controls were enrolled in the present study and underwent resting-state functional magnetic resonance imaging. The functional connectivity (FC) analysis and two-sample t-tests were applied to investigate the alterations of striatum-related connectivity in patients compared with HCs (significant threshold at p<0.05, false discovery rate corrected), and during which Fisher's r-to-z transformation was adopted and the resulting z values were used as the statistical FC values. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.001DOI Listing
June 2020
2.188 Impact Factor

Estimations of Typical, Ideal, Premature Ejaculation, and Actual Latencies by Men and Female Sexual Partners of Men During Partnered Sex.

J Sex Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychology, Valparaiso University, Valparaiso, IN, USA. Electronic address:

Background: The ejaculation latency (ELT) criterion for men with premature ejaculation (PE), including its 2 major subtypes of lifelong and acquired, relies heavily on expert opinion, yet such information represents only one source of data for this determination; furthermore, information regarding ELTs for PE within specific subgroups of men (eg, gay, bisexual) has been lacking.

Aim: To obtain data regarding men's lived experiences and expectations regarding typical ejaculation, ideal ejaculation, and PE and (for men) self-reported ejaculatory latencies during partnered sex across a variety a groups, including men vs women (ie, sexual partners of men), men with and without PE, and straight vs gay/bisexual men.

Methods: We recruited 1,065 men and sexual partners of men, asking them to estimate typical ejaculation, ideal ejaculation, and PE and (for men) self-latencies through an online survey posted on social media. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.04.317DOI Listing

High performance liquid chromatography - Mass spectrometric bioanalytical method for the determination of dapoxetine in human plasma: Application for bioequivalence study.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jul 15;1149:122154. Epub 2020 May 15.

Jordan Center for Pharmaceutical Research (JCPR), Amman, Jordan.

Dapoxetine is an oral medication used for treatment of premature ejaculation (PE) in men aged (18-64 years). In this study, we present a validated, precise and sensitive method for determination of dapoxetine in human plasma by liquid chromatography/ electrospray ionization-tandem mass spectrometry. Dapoxetine and the internal standard (Dapoxetine- d) were extracted from plasma via liquid-liquid extraction (LLE). Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122154DOI Listing

Clinical effect of computed guided pudendal nerve block for patients with premature ejaculation: a pilot study.

Scand J Urol 2020 Jun 1;54(3):258-262. Epub 2020 Jun 1.

Department of Urology, St Phillibert Hospital, GHICL, Université Nord de France, Lille, France.

Premature ejaculation has a complex etiology, and its pathophysiology is still unclear, with penile hypersensitivity being the most accepted hypothesis. The aim was to investigate the efficacy and safety of a computed tomography-guided pudendal nerve block at the level of the sacrospinous ligament and the Alcock's canal in patients with premature ejaculation refractory to conventional pharmacological treatment. This is a prospective pilot study involving five patients suffering from premature ejaculation refractory to standard treatment and clinical features of pudendal nerve entrapment. Read More

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http://dx.doi.org/10.1080/21681805.2020.1770855DOI Listing

Effect of tramadol dependence on male sexual dysfunction.

Interdiscip Toxicol 2019 Dec 30;12(4):157-162. Epub 2020 Apr 30.

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Tramadol dependence became an increasing and alarming problem in the Egyptian community. Wide availability of tramadol as a pain killer and its role in the treatment of premature ejaculation may be the most apparent causes of increased magnitude of the problem among youth who believe that tramadol has a positive impact on their sexual functions. This study aimed to explore the real impact of chronic tramadol administration on sexual functions in males dependent on tramadol. Read More

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http://dx.doi.org/10.2478/intox-2019-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247366PMC
December 2019

Two-Step Optimization to Develop a Transdermal Film Loaded With Dapoxetine Nanoparticles: A Promising Technique to Improve Drug Skin Permeation.

Dose Response 2020 Apr-Jun;18(2):1559325820923859. Epub 2020 May 7.

Faculty of Pharmacy, Department of Pharmaceutics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Dapoxetine (DPX) is an orally administered drug for the treatment of premature ejaculation (PE). One of the challenges of administering DPX orally as a tablet is its poor bioavailability (ie, 42%) due to extensive first-pass metabolism. Thus, it is vital to develop a new formulation and mode of delivery to achieve the unmet needs of PE treatment. Read More

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http://dx.doi.org/10.1177/1559325820923859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218328PMC

Advantages and limitations of current premature ejaculation assessment and diagnostic methods: a review.

Transl Androl Urol 2020 Apr;9(2):743-757

The Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.

Premature ejaculation (PE) is the most common male sexual dysfunction worldwide. Characteristic symptoms of PE are unexpected, rapid, complete ejaculation, which negatively impacts the sexual act for both sexual partners. Despite the existence of a definitive PE classification system and various diagnostic tools, diagnosing PE is still challenging due to the limitations associated with the assessment of this condition. Read More

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http://dx.doi.org/10.21037/tau.2019.12.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215025PMC

Development of nanotechnology in andrology.

Transl Androl Urol 2020 Apr;9(2):702-708

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Since first introduced in 1980s, nanotechnology has always been the eye-catching point as its providing us with new approaches to explore the microscopic world. Many nanotechnology-associated novel technologies have been brought into clinical use in the past decades and uncountable patients benefited from them, which convinces us of a bright prospect of nanotechnology in the field of medicine. In this review, literatures concerning nanotechnology applications in andrology were retrieved and we made a comprehensive discussion on drug delivery, gene therapy and stem cell therapy use in andrology, which calls for the engagement of nanotechnology. Read More

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http://dx.doi.org/10.21037/tau.2020.01.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214986PMC

Do women's Relationship Satisfaction and Sexual Functioning Vary as a Function of Their Male Partners' Premature Ejaculation Symptoms?

J Sex Marital Ther 2020 May 15:1-9. Epub 2020 May 15.

Department of Psychology, Åbo Akademi University, Turku, Finland.

The present study investigated how women's sexual functioning and relationship satisfaction are associated with their partner's premature ejaculation (PE) symptoms, and whether prevalence rates of PE differ when women report on their male partners compared to male self-report. The sample comprised of responses from 1,779 Finnish women (mean age 33.3 years) and a control group of 1,024 Finnish men. Read More

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http://dx.doi.org/10.1080/0092623X.2020.1766612DOI Listing

Premature ejaculation in patients with lower urinary tract symptoms: a systematic review.

Int J Impot Res 2020 May 11. Epub 2020 May 11.

Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia.

Lower urinary tract symptoms (LUTS) refer to a group of symptoms related to bladder, prostate, and urethra. LUTS are common in men and the severity increases with age. LUTS are frequently associated with sexual dysfunction, such as premature ejaculation (PE), standing as the most common sexual dysfunction in men. Read More

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http://dx.doi.org/10.1038/s41443-020-0298-5DOI Listing

Phosphodiesterase-5 Inhibitors for Premature Ejaculation: Systematic Review and Meta-Analysis of Placebo-Controlled Trials.

Am J Mens Health 2020 May-Jun;14(3):1557988320916406

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

The purpose of this analysis is to assess the efficacy and safety of phosphodiesterase-5 inhibitors (PDE5Is) for the treatment of premature ejaculation (PE). A comprehensive search was performed to ascertain from trials about PDE5Is for the treatment of PE and compare the results, including intravaginal ejaculatory latency time (IVELT), score of sexual satisfaction scale, and side effects, between the group treated with PDE5Is and that treated with placebo. Seven studies involving a total of 471 patients were included in this meta-analysis. Read More

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http://dx.doi.org/10.1177/1557988320916406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233005PMC

Editorial Comment: Novel Treatment for Premature Ejaculation in the Light of Cur-rently Used Therapies: A Review.

Authors:
Valter Javaroni

Int Braz J Urol 2020 Jul - Aug;46(4):665-666

Departamento de Andrologia, Hospital Federal do Andaraí, Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.04.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239309PMC

Interventions for sexual dysfunction following stroke.

Cochrane Database Syst Rev 2020 May 1;5:CD011189. Epub 2020 May 1.

Department of Medicine, University of Melbourne, Melbourne, Australia.

Background: Sexual dysfunction following stroke is common but often is poorly managed. As awareness of sexual dysfunction following stroke increases as an important issue, a clearer evidence base for interventions for sexual dysfunction is needed to optimise management.

Objectives: To evaluate the effectiveness of interventions to reduce sexual dysfunction following stroke, and to assess adverse events associated with interventions for sexual dysfunction following stroke. Read More

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http://dx.doi.org/10.1002/14651858.CD011189.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197697PMC

Human cremaster muscle and cremasteric reflex: A comprehensive review.

Clin Neurophysiol 2020 Jun 31;131(6):1354-1364. Epub 2020 Mar 31.

Department of Neurology, Ege University Medical School Hospital, Bornova, İzmir, Turkey.

Objective: Human research on the cremaster muscle (CM), cremasteric reflex (CMR) and genitofemoral nerve (GFN) and reports on their clinical applications using electrophysiological and histological techniques are rare. We aimed to present a detailed review of the human CM and CMR based on our earlier publications and relevant literature.

Methods: Electromyography (EMG) of the CM was recorded using disposable needle electrodes. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.011DOI Listing

"The Overactive Pelvic Floor (OPF) and Sexual Dysfunction" Part 1: Pathophysiology of OPF and Its Impact on the Sexual Response.

Sex Med Rev 2020 Mar 29. Epub 2020 Mar 29.

Physio Works Muskoka, Huntsville, ON, Canada.

Introduction: Overactive pelvic floor (OPF) muscles are defined as muscles that do not relax, or may even contract, when relaxation is needed, for example, during micturition or defecation. Conditions associated with OPF are multifactorial and include multiple possible etiologies and symptom complexes. The complex interplay between biological and psychosocial elements can lead to the persistence of OPF symptoms along with psychological and emotional distress. Read More

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http://dx.doi.org/10.1016/j.sxmr.2020.02.002DOI Listing

[Personality and psychological characteristics of premature ejaculation patients].

Zhonghua Nan Ke Xue 2019 Nov;25(11):996-1000

Department of Andrology, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.

Objective: To investigate the personality and psychological characteristics of premature ejaculation (PE) patients and the correlation between them two.

Methods: Using Eysenck Personality Questionnaire (EPQ) and Symptom Checklist 90 (SCL-90), we conducted an investigation among 94 PE patients seeking medical advice in Drum Tower Hospital from October 2018 to February 2019.

Results: The neuroticism score of the PE patients on EPQ was significantly higher than the national norm of adult males (t = 12. Read More

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November 2019

[Correlation of betweenness centrality of the right hemispheric network with ejaculatory function in premature ejaculation patients].

Zhonghua Nan Ke Xue 2019 Jul;25(7):613-618

Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China.

Objective: To explore the topological properties of the betweenness centrality of the nodes and edges in the brain white matter network of premature ejaculation (PE) patients and analyze the correlation of the importance of the key brain regions and interregional white matter structural connectivity with the ejaculatory function of the patients.Method: We collected the demographic and clinical data, along with the T1 and MR diffusion tensor imaging (MR-DTI) data, on 18 PE patients and 22 normal controls matched in age, sex and education. After preprocessing of the data obtained, we divided the whole brain into 90 symmetrical cortical and subcortical regions (defined as nodes of the brain network) by automated anatomical labeling, examined the structural connectivity between different brain regions by probabilistic white matter fiber tracking (defined as edges of the brain network), and calculated the betweenness centrality of the nodes and edges using the brain connection toolbox. Read More

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[Updated application of penile electrophysiological examination in the diagnosis and treatment of male sexual dysfunction].

Zhonghua Nan Ke Xue 2019 Jun;25(6):559-565

Graduate School, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Electrophysiological examination of penile nerves involves detection of somatic and autonomic nerves, including dorsal nerve somatosensory evoked potential, cavernous muscle reflex, skin sympathetic response, cavernous electromyography, and others, which plays an important role in the diagnosis of male sexual dysfunction, such as ED and premature ejaculation, as well as in the selection of treatment methods and evaluation of therapeutic effects. Due to the complex mechanisms of the brain, spinal cord and peripheral nerve pathways relating to erectile and ejaculatory centers in men and many unknown areas in penile electrophysiological techniques, penile electrophysiological examination has not been widely accepted by doctors and patients. Further studies are needed to provide more scientific and convincing evidence in this field. Read More

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[Correlation between the phenotypic domains of the UPOINT system and sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome].

Zhonghua Nan Ke Xue 2019 Jun;25(6):496-499

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.

Objective: To investigate the correlation of the six phenotypic domains of the UPOINT (urinary, psychosocial, organ-specific, infection, neurologic/systemic, and tenderness) system with premature ejaculation (PE) and ED in male patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: We collected the clinical data on 453 cases of CP/CPPS from December 2016 to December 2017, including the general information, CP symptoms, sexual life history, intravaginal ejaculatory latency time (IELT), NIH-CPSI, and IIEF-5 scores. We classified the patients according to the UPOINT system. Read More

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Changing Aspects of Male Sexual Functions Accompanying Treatment of Benign Prostatic Hyperplasia With Silodosin 8 mg Per Day.

J Sex Med 2020 Jun 23;17(6):1094-1100. Epub 2020 Mar 23.

Department of Urology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey.

Background: Alpha-adrenergic antagonist treatment for benign prostatic hyperplasia (BPH) and drug-related sexual side effects are frequent in aging men.

Aim: To investigate functional changes in erectile and ejaculatory aspects of male sexuality under Silodosin 8 mg per day treatment for BPH.

Methods: Sexually active patients diagnosed with BPH and who initiated Silodosin treatment were the subjects of the study. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.02.023DOI Listing

[Objective indexes for the diagnosis of premature ejaculation: An update].

Zhonghua Nan Ke Xue 2019 Feb;25(2):164-167

Department of Urology, The Second Hospital Affiliated to Harbin Medical University, Harbin, Heilongjiang 150001, China .

Premature ejaculation is a common male sexual dysfunction disorder, and there are many controversies over its definition. With deeper insights into the etiology and pathogenesis of premature ejaculation, more and more auxiliary examinations are used in its diagnosis, prognostic evaluation and treatment, such as transrectal ultrasonography of seminal vesicles, determination of serum 5-hydroxytryptamine (5-HT) concentration, serum hormone levels, penile sensitivity detection, brain function tests, and genetic sequencing. This review outlines the latest advances in the auxiliary examination of premature ejaculation and provides clinicians with some diagnostic indexes or methods of premature ejaculation for reference. Read More

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February 2019

"Doc, if it were you, what would you do?": a survey of Men's Health specialists' personal preferences regarding treatment modalities.

Int J Impot Res 2020 Mar 23. Epub 2020 Mar 23.

Department of Urology, University of California Irvine, Oakland, CA, United States.

Men's Health is a urological subspecialty that is at the forefront of innovation, but little data exist evaluating the attitudes that andrologists have toward the current treatment modalities available for managing Men's Health conditions. A survey of 37 questions asking what providers would choose as treatment for common conditions was distributed online via Survey Monkey to members of the Sexual Medicine Society of North America and European Society for Sexual Medicine. A total of 115 respondents completed the survey after an initial screening question. Read More

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http://dx.doi.org/10.1038/s41443-020-0263-3DOI Listing

The relationship between premature ejaculation and anogenital distance.

Andrologia 2020 Jul 23;52(6):e13571. Epub 2020 Mar 23.

Sultanbeyli State Hospital, İstanbul, Turkey.

Premature ejaculation is a common male sexual disease in andrology practice. The goal of essay is to investigate the relation of anogenital distance that predicts prenatal testosterone exposure with premature ejaculation. Between January and May 2019, 150 men were participated in the study. Read More

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http://dx.doi.org/10.1111/and.13571DOI Listing
July 2020
1.172 Impact Factor

Premature Ejaculation: From Physiology to Treatment.

J Family Reprod Health 2019 Sep;13(3):120-131

Urology Department, Cova da Beira University Hospital Centre, Covilhã, Portugal.

To review in literature about the concept of premature ejaculation from physiology to treatment. A literature search conducted with Pubmed and Cochrane. An accurate clinical history is the best diagnostic method, and in the majority of the cases it is enough to differentiate between primary and acquired premature ejaculation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072026PMC
September 2019

[Premature ejaculation: the main physiological mechanisms and new approaches to the treatment].

Urologiia 2020 Mar(1):95-102

Moscow Research and Education Center of the Lomonosov Moscow State University Moscow Research and Education.

Premature ejaculation (PE) is characterized by an early ejaculation, which occurs within 1 minute after or before vaginal penetration. PE is the most common sexual problem and leads to a number of negative psychological consequences. To understand the etiopathogenesis of PE, it is necessary to understand the physiological mechanisms of the ejaculatory reflex. Read More

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[Sexual dysfunction in patients with chronic prostatitis and its treatment].

Authors:
M I Davidov

Urologiia 2020 Mar(1):51-58

FGBOU VO Academician Ye. A. Vagner Perm State Medical University of the Ministry of Healthcare of the Russian Federation, Perm, Russia.

Aim: to study the frequency and type of sexual disorders in patients with chronic prostatitis (CP) and to evaluate the efficiency of Vitaprost and the biologically active complex NeuroDose in treating sexual dysfunctions.

Materials And Methods: The study was conducted in 2015-2019 and consisted of two stages.

Study Design: At the first stage, the frequency and type of sexual disorders were evaluated in 422 patients with CP. Read More

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The heart rate recovery is impaired in participants with premature ejaculation.

Andrologia 2020 Jun 19;52(5):e13573. Epub 2020 Mar 19.

Department of Urology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.

Premature ejaculation (PE) is one of the most common sexual disorders in men. Excessive activity of the sympathetic nervous system is considered as one of the pathological mechanisms of PE. Heart rate recovery (HRR) is a noninvasive and easily applicable method for evaluating autonomic functions. Read More

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http://dx.doi.org/10.1111/and.13573DOI Listing

Relationship between Hypogonadal Symptoms, Sexual Dysfunction and Chronic Prostatitis in Middle-Aged Men by Self-Reported Questionnaires, even without Biochemical Testosterone Deficiency.

World J Mens Health 2020 Apr;38(2):243-249

Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Purpose: To investigate the association of erectile dysfunction (ED), premature ejaculation (PE), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men with late-onset hypogonadism (LOH).

Materials And Methods: We reviewed the data of 408 enrolled men between January 2014 and January 2019. All participants completed the Androgen Deficiency in the Aging Male (ADAM), international index of erectile function-5 (IIEF-5), National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), and premature ejaculation diagnostic tool (PEDT) questionnaires. Read More

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http://dx.doi.org/10.5534/wjmh.190117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076313PMC

Efficacy and safety of dapoxetine for premature ejaculation: an updated systematic review and meta-analysis.

Sex Health 2019 08;16(4):301-313

Department of Urology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, 99 Longcheng Street, Taiyuan, Shanxi 030024, China; and Corresponding author Email:

We conducted a systematic review and meta-analysis of published randomised controlled trials of dapoxetine for premature ejaculation. We systematically searched Embase, PubMed, Cochrane, Web of Knowledge, FDA.gov and Clinical Trials. Read More

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http://dx.doi.org/10.1071/SH18005DOI Listing

Association Between Lifelong Premature Ejaculation and Polymorphism of Tryptophan Hydroxylase 2 Gene in the Han Population.

Sex Med 2020 Jun 10;8(2):223-229. Epub 2020 Mar 10.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Introduction: Premature ejaculation (PE) is widely regarded as one of the most common sexual dysfunctions in men. The neurobiogenesis of PE is complex and involves the serotoninergic (5-HT) system.

Aim: In this study, we investigated whether polymorphisms in the tryptophan hydroxylase 2 (TPH2) gene were associated with lifelong PE (LPE). Read More

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http://dx.doi.org/10.1016/j.esxm.2020.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261684PMC

Profile of sexuality and symptoms of lower urinary tract in non-institutionalized elderly.

Int Braz J Urol 2020 May-Jun;46(3):374-380

Faculdade de Medicina de Jundiai, Jundiai, SP, Brasil.

Introduction: Urinary or sexual dysfunction in the elderly are underreported. However, they are highly prevalent. This study aims to identify the prevalence of these conditions. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2019.0162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088472PMC

The decline in sexual function, psychological disorders (anxiety and depression) and life satisfaction in older men: A cross-sectional study in a hospital-based population.

Andrologia 2020 Jun 11;52(5):e13559. Epub 2020 Mar 11.

Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.

This study explored the relationships between the decline in sexual function and psychological burdens and life satisfaction in older men with the aim of providing prospective targets for interventions. From January 2016 to January 2019, we selected 1,326 men aged over 50 years old. We adopted the International Index of Erectile Function-5 (IIEF-5), self-estimated intravaginal ejaculatory latency time (IELT), the premature ejaculation diagnostic tool (PEDT), the General Anxiety Disorder-7 (GAD-7), the Patients Health Questionnaire-9 (PHQ-9), the satisfaction with life scale and the control, autonomy, self-realisation and pleasure scale (CASP-19) to measure premature ejaculation, erectile dysfunction and well-being (including, depression, anxiety, and life quality and satisfaction) respectively. Read More

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http://dx.doi.org/10.1111/and.13559DOI Listing
June 2020
1.172 Impact Factor

Oral dapoxetine versus topical lidocaine as on-demand treatment for lifelong premature ejaculation: A randomised controlled trial.

Andrologia 2020 Jun 9;52(5):e13558. Epub 2020 Mar 9.

Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.

This trial aimed to assess the efficacy of on-demand oral dapoxetine versus topical lidocaine treatments for lifelong PE. Cases with lifelong PE were randomised to start treatment by oral dapoxetine 60 mg or topical lidocaine 10% spray. The intravaginal ejaculatory latency time (ILET), validated Arabic Index for PE (AIPE), Sexual Health Inventory for Men (SHIM) and frequency of intercourse/week were recorded at the baseline and after 12 weeks treatment period of the first medication before two weeks washout period and then crossing over to the other one for another 12 weeks. Read More

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http://dx.doi.org/10.1111/and.13558DOI Listing

Impact of irregular marital cohabitation on quality of life and sexual dysfunction in infertile men from upper Egypt.

Clin Exp Reprod Med 2020 Mar 1;47(1):77-82. Epub 2020 Mar 1.

Department of Dermatology and Andrology, Faculty of Medicine, Helwan University, Helwan, Egypt.

Objective: Irregular patterns of marital cohabitation are a common problem in upper Egypt due to employment conditions. The objective of this study was to investigate the effect of irregular marital cohabitation on the quality of life and sexual function of infertile men.

Methods: In total, 208 infertile men were included and divided into two groups. Read More

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http://dx.doi.org/10.5653/cerm.2019.03118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127902PMC

Editorial for "Altered Functional Connectivity of Hypothalamus in Lifelong Premature Ejaculation Patients".

Authors:
Daniela Cevolani

J Magn Reson Imaging 2020 Mar 6. Epub 2020 Mar 6.

University of Bologna, c/o Neuroradiology Unit, "Bellaria" Hospital, Bologna, Italy.

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http://dx.doi.org/10.1002/jmri.27128DOI Listing

Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study.

Andrology 2020 Feb 26. Epub 2020 Feb 26.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Background: Penile hypersensitivity is one of the main pathological mechanisms of premature ejaculation. However, little is known about the neurophysiological mechanism of penile peripheral nerve sensitization. Piezo Type Mechanosensitive Ion Channel Component 2 (PIEZO2), was recently identified as a mechanically sensitive channel. Read More

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http://dx.doi.org/10.1111/andr.12779DOI Listing
February 2020

Objective and Subjective Measures of Premature Ejaculation: How Closely Do They Correspond and How Well Are the Subjective Measures Recalled?

J Sex Med 2020 Apr 20;17(4):634-644. Epub 2020 Feb 20.

Australian Centre for Sexual Health, St. Leonards, NSW, Australia.

Background: Clinical trials evaluating new treatments for premature ejaculation (PE) should ideally include both objective end points and patient reported outcomes (PROs), but there is no consensus currently over the optimal measures or combination of outcomes. In addition, many PROs use a 1-month recall period, despite concerns about potential recall bias.

Aims: Data from a clinical trial of men with lifelong PE were used to examine the consistency of 2 core items of the Premature Ejaculation Profile (PEP), a widely used PRO for assessing subjective aspects of PE. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.01.002DOI Listing

Altered Functional Connectivity of Hypothalamus in Lifelong Premature Ejaculation Patients.

J Magn Reson Imaging 2020 Feb 18. Epub 2020 Feb 18.

Life Science Research Center, School of Life Science and Technology, Xidian University, Xi'an, China.

Background: As one of the most prevalent sexual dysfunctions in men, lifelong premature ejaculation (PE) often leads to patient distress. The hypothalamus is implicated in the ejaculatory control of healthy males. However, we do not know whether the hypothalamus-related intrinsic connectivity is altered in lifelong PE patients. Read More

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http://dx.doi.org/10.1002/jmri.27099DOI Listing
February 2020
3.210 Impact Factor

Association of NE, leptin, and 5-HT with electrophysiological parameters in patients with primary premature ejaculation.

Andrology 2020 Feb 18. Epub 2020 Feb 18.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE).

Methods: We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory latency time (IELT) and the premature ejaculation diagnostic tool (PEDT) scores between 57 PPE patients and 42 healthy control men as controls, who were recruited between September 2016 and January 2019. Additionally, the amplitude and latency of PSSR were measured and compared between the two groups. Read More

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http://dx.doi.org/10.1111/andr.12773DOI Listing
February 2020

[Ejaculatory dysfunction].

Ugeskr Laeger 2020 Jan;182(5)

This review summarises the current knowledge of ejaculatory dysfunction, which is a group of prevalent sexual disorders with a substantial impact on sexual health of men and their partners. A thorough medical history is the most important evaluation tool. Several treatments for premature ejaculation are available; however, a successful treatment outcome depends on pre-treatment alignment of expectations. Read More

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January 2020

Inhibitory Role of Gamma-Aminobutyric Receptors in Paraventricular Nucleus on Ejaculatory Responses in Rats.

J Sex Med 2020 Apr 7;17(4):614-622. Epub 2020 Feb 7.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: Although abnormal sympathetic nerve system (SNS) activity has been demonstrated in the pathogenesis of ejaculation disorders, few data are available on its underlying mechanism.

Aim: To investigate whether differences in ejaculatory behavior of rats were associated with the state of SNS activity and gamma-aminobutyric (GABA) receptor expressions in the paraventricular nucleus (PVN) of the hypothalamus and the effects of GABA receptors in the PVN on ejaculatory behavior.

Methods: Based on ejaculatory performance, Sprague-Dawley rats were divided into "sluggish," "normal," and "rapid" ejaculators. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.01.006DOI Listing

The effect of post-circumcision mucosal cuff length on premature ejaculation.

Can Urol Assoc J 2020 Feb 4. Epub 2020 Feb 4.

Department of Urology, SB Izmir Odemis State Hospital, Izmir, Turkey.

Introduction: Circumcision is considered the most common surgical procedure in the world. We aimed to compare the length of mucosal cuff after circumcision in patients with and without a complaint of premature ejaculation (PE).

Methods: Sexually active patients without erectile dysfunction that presented to the urology polyclinic between March 2018 and June 2018 were included in this multicentered, prospective study. Read More

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http://dx.doi.org/10.5489/cuaj.6016DOI Listing
February 2020

Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice.

BMC Urol 2020 Feb 3;20(1):11. Epub 2020 Feb 3.

Andrology Center, Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, No. 59A, Di'anmen West St., Xicheng District, Beijing, 100034, China.

Background: The treatment effect of dapoxetine in real-world practice is not well established. This study was to investigate the factors influencing efficacy of dapoxetine for the treatment of Premature ejaculation (PE) in the real-world setting.

Methods: Altogether 154 patients were followed up between Jan 2015 and Dec 2015. Read More

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http://dx.doi.org/10.1186/s12894-020-0580-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998231PMC
February 2020

Sexual dysfunction in men on buprenorphine - naloxone-based substitution therapy.

Indian J Psychiatry 2020 Jan-Feb;62(1):66-72. Epub 2020 Jan 3.

Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, Odisha, India.

Background: The literature on sexual dysfunction in patients on buprenorphine-naloxone (BNX) substitution is limited.

Materials And Methods: This research aimed to study the prevalence and correlates of sexual dysfunction in men on BNX substitution therapy. We recruited consecutive forty men from BNX clinic, who had received BNX for at least 6 months, who were free from any recent illicit drug use (confirmed by urine chromatographic immune assay), and who were either married or had a stable sexual partner. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_195_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964450PMC
January 2020

A Double Blind, Placebo Controlled, Randomized Trial to Evaluate the Efficacy and Tolerability of On-Demand Oral Pregablin (150 mg and 75 mg) in Treatment of Premature Ejaculation.

J Sex Med 2020 Mar 22;17(3):442-446. Epub 2020 Jan 22.

Dermatology and Venereology Department, Bilbeis Hospital, Al Sharqia, Egypt.

Introduction: Although premature ejaculation (PE) is a common sexual dysfunction, the available options for PE treatment remain unsatisfactory.

Aim: To evaluate the effect of on-demand oral pregabalin on the intravaginal ejaculation latency time (IELT).

Method: We conducted a multiarm double-blinded placebo-controlled randomized clinical trial that enrolled 120 patients with PE who were divided equally into 3 groups (A, B, and C). Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.12.014DOI Listing