1,672 results match your criteria Premature Ejaculation


Topical Agents for Premature Ejaculation: A Review.

Sex Med Rev 2019 Apr 12. Epub 2019 Apr 12.

Park Nicollet/HealthPartners, Department of Sexual Medicine and Male Infertility, Minneapolis, Minnesota, USA.

Introduction: Premature ejaculation (PE) is among the most common sexual dysfunctions that affect men. Currently, topical medications are considered a first-line treatment option for PE, with no specific medication having market approval in the United States specifically for the treatment of PE. Topical agents for PE include eutectic mixture of local anesthetics cream, topical eutectic mixture for premature ejaculation spray, severance secret-cream, resiniferatoxin, and an assortment of over-the-counter treatments, including medicated condoms, sprays, and wipes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sxmr.2019.03.003DOI Listing

Epidemiology of sexual disorders in general medical practice: An Italian survey.

Urologia 2019 Apr 14:391560319842955. Epub 2019 Apr 14.

1 Department of Urology, Ospedale Policlinico San Martino - Istituto di Ricerca e Cura a Carattere Scientifico per l'Oncologia, University of Genoa, Genoa, Italy.

Objective: To report the results of a survey supported by the Italian Andrological Association (ASS.A.I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391560319842955DOI Listing

Pelvic floor muscle training improves erectile dysfunction and premature ejaculation: a systematic review.

Physiotherapy 2019 Jan 14. Epub 2019 Jan 14.

College of Healthcare Sciences, James Cook University, Townsville, Australia. Electronic address:

Background: Erectile dysfunction (ED) and premature ejaculation (PE) often have underlying musculoskeletal abnormalities. Despite this, traditional management has focused on pharmaceutical prescription.

Objective: To investigate the efficacy of pelvic floor muscle training in treating ED and PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physio.2019.01.002DOI Listing
January 2019

Anatomic Basis and Clinical Effect of Selective Dorsal Neurectomy for Patients with Lifelong Premature Ejaculation: A Randomized Controlled Trial.

J Sex Med 2019 Apr;16(4):522-530

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Introduction: Although guidelines from the American Urological Association and European Association of Urology do not consider surgical treatment for premature ejaculation (PE), the use of selective dorsal neurectomy (SDN) has increased for many years in Asian countries.

Aim: To evaluate anatomic basis and clinical effect of SDN in patients with PE in mainland China.

Methods: All of the patients included in the study had redundant foreskin, and they were assigned to 2 groups: group 1, composed of 46 patients with redundant foreskin, and group 2, composed of 96 patients with redundant foreskin and PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.01.319DOI Listing
April 2019
2 Reads

Ten-Year Interval Changes in the Prevalence of Self-Identified Premature Ejaculation and Premature Ejaculation Based on an Estimated Intravaginal Ejaculation Latency Time of <3 Minutes in the General Population: The Korean Internet Sexuality Survey (KISS) 2016.

J Sex Med 2019 Apr;16(4):512-521

Department of Urology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea; College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address:

Introduction: Because the prevalence of premature ejaculation (PE) may change with time, few studies have been conducted over a 10-year time interval.

Aim: A 10-year time interval survey to determine whether there was a change in the prevalence of self-identified PE and PE defined on the basis of an estimated intravaginal ejaculation latency time of <3 minutes in adult Korean men, even after adjusting for various sociocultural factors.

Methods: We sent an e-mail to the panels registered in the same Internet survey agency in 2006, asking them to participate in a questionnaire-based survey of the same study design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.02.003DOI Listing
April 2019
1 Read

Predictors of Sexual Dysfunction in Veterans with Post-Traumatic Stress Disorder.

J Clin Med 2019 Mar 29;8(4). Epub 2019 Mar 29.

County General Hospital Našice, 31500 Našice, Croatia.

Background: The problems in sexual functioning among patients with post-traumatic stress disorder (PTSD) are often overlooked, although scientific research confirms high rates of sexual dysfunctions (SD) particularly among veterans with PTSD. The main objective of this study was to systematically identify predictors of SD among veterans with PTSD.

Methods: Three hundred veterans with PTSD were included in the cross-sectional study. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2077-0383/8/4/432
Publisher Site
http://dx.doi.org/10.3390/jcm8040432DOI Listing
March 2019
4 Reads

Erectile Dysfunction and Premature Ejaculation in Homosexual and Heterosexual Men: A Systematic Review and Meta-Analysis of Comparative Studies.

J Sex Med 2019 Mar 26. Epub 2019 Mar 26.

Andrology Unit, Department of Clinical Medicine, Public Health, Life Sciences and the Environment, University of L'Aquila, L'Aquila, Italy.

Introduction: Comparative studies on differences in sexual function outcomes between homosexual and heterosexual men are sparse and inconclusive.

Aim: To systematically evaluate whether, and to what extent, a statistically significant difference exists in the odds of erectile dysfunction (ED) and premature ejaculation (PE) between homosexual and heterosexual men.

Methods: A thorough search of Medline, SCOPUS, CINAHL, and Web of Science databases was carried out to identify case-control studies comparing the prevalence of ED and PE in homosexual and heterosexual men. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.02.014DOI Listing
March 2019
1 Read

Premature ejaculation: an update on definition and pathophysiology.

Asian J Androl 2019 Mar 8. Epub 2019 Mar 8.

Department of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha 00974, Qatar.

Premature ejaculation (PE) is the most common male sexual dysfunction, which represents a diagnostic as well as a therapeutic challenge for physicians. However, no universally accepted definition is currently available for PE. As a result, physicians continue to diagnose patients with PE according to major guidelines set by the professional societies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aja.aja_122_18DOI Listing
March 2019
8 Reads
2.530 Impact Factor

Sexual Dysfunction in Men with Prediabetes.

Sex Med Rev 2019 Mar 6. Epub 2019 Mar 6.

Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.

Introduction: Previous studies have shown a strong association between diabetes mellitus (DM) and the frequency and severity of some aspects of male sexual dysfunction (SD). The same relationship with prediabetes (preDM) has been less well investigated.

Aim: To systematically review the current literature on the association between preDM and SD, focusing on erectile dysfunction (ED), sex steroid hormone alterations, and premature ejaculation (PE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sxmr.2018.11.008DOI Listing
March 2019
1 Read

Sildenafil/Viagra in the treatment of premature ejaculation.

Int J Impot Res 2019 Mar 5;31(2):65-70. Epub 2019 Mar 5.

Department of Urology, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

The arrival of Pfizer's blue pill Sildenafil in 1998 brought a great relief both to patient and physician signalling the start of a great era of medical therapy in sexual medicine. Since then the sexual medicine experts have been prescribing sildenafil in erectile dysfunction with acceptable minor adverse events. But the use of sildenafil in premature ejaculation (PE) is still debated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41443-018-0099-2DOI Listing
March 2019
2 Reads

Content Validity of the Premature Ejaculation Profile, Original and Per-Event Formats, in Men with Lifelong Premature Ejaculation.

J Sex Med 2019 Apr 2;16(4):569-576. Epub 2019 Mar 2.

Clinical Outcomes Solutions, Canterbury, UK.

Background: The Premature Ejaculation Profile (PEP) is a patient-reported outcome (PRO) measure that is widely used in clinical research in men with premature ejaculation (PE) but has not been fully validated for men meeting the current International Society for Sexual Medicine (ISSM) definition of lifelong PE.

Aim: To explore the content validity of the PEP (original 1-month recall version and new event-driven version) in men meeting current definitions of lifelong PE and to understand the relevance of the concept of ejaculation control.

Methods: In-depth individual interviews were conducted with 24 men in a stable heterosexual relationship, including 15 with lifelong PE, 4 with acquired PE (with intravaginal ejaculation latency time values confirmed during a 4-week period of no treatment), and 5 with no sexual dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.01.311DOI Listing
April 2019
2 Reads

Development and validation of an HPLC-UV method for simultaneous determination of sildenafil and tramadol in biological fluids: Application to drug-drug interaction study.

J Pharm Biomed Anal 2019 May 19;168:201-208. Epub 2019 Feb 19.

Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. Electronic address:

The introduction of sildenafil (SDF) to treat erectile dysfunction has solved a widespread condition with negative on the quality of life. Recently, the co-administration of tramadol (TMD) with SDF to manage premature ejaculation has illegally increased and thus drug-drug interaction studies of these drugs became of great importance. Although certain biological functions have been altered upon co-administration of the two drugs, methods for their determination in vivo to understand their interactions have yet to be published. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.02.025DOI Listing
May 2019
9 Reads

[Ejaculation disorders in multiple sclerosis: Prospective study of 44 patients].

Prog Urol 2019 Feb 25. Epub 2019 Feb 25.

GRC 01, Green - groupe de recherche clinique en neuro-urologie, Sorbonne universités, AP-HP, hôpital Tenon, 75020 Paris, France; Service de neuro-urologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Introduction: To analyze in a descriptive way the ejaculation disorders during MS and to study the correlations between dysejaculations, other sexual, urinary and anorectal disorders.

Material: Prospective, monocentric, non-interventional study. Ejaculation disorders were assessed by Premature Ejaculation Profile (PEP) scores, intravaginal latency, and the Male Sexual Health Questionnaire - Ejaculation (MSHQ-Ej). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.purol.2019.02.001DOI Listing
February 2019
6 Reads

Effect of premature ejaculation desensitisation therapy combined with dapoxetine hydrochloride on the treatment of primary premature ejaculation.

Andrologia 2019 May 20;51(4):e13135. Epub 2019 Feb 20.

Andrology Department, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China.

To evaluate the overall treatment benefits of premature ejaculation desensitisation therapy combined with 30 mg dapoxetine hydrochloride treatment on patients with primary premature ejaculation (PPE). Ninety-nine PPE patients were randomly divided into two groups at the ratio of 2:1. Sixty-six PPE patients received premature ejaculation desensitisation therapy accomplished by Weili Automatic Semen Collection-Penis Erection Detection and Analysis workstation (WLJY-2008) combined with 30 mg dapoxetine hydrochloride treatment (DTCD group), and another 33 patients received 30 mg dapoxetine hydrochloride-only treatment (DO group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/and.13135DOI Listing
May 2019
2 Reads

Sexual Dysfunction among Men in Rural Tamil Nadu: Nature, Prevalence, Clinical Features, and Explanatory Models.

Indian J Psychol Med 2019 Jan-Feb;41(1):81-86

Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India.

Background And Aim: There is a dearth of community data on nature, prevalence, clinical features, and explanatory models related to sexual dysfunction among men, particularly from rural India. This study attempted to examine different aspects of male sexual dysfunction and misconceptions in the community.

Materials And Methods: Villages in Kaniyambadi Block, Vellore district were stratified, and four were randomly selected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_153_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337923PMC
February 2019
3 Reads

The Penile Sensitivity Ratio: A Novel Application of Biothesiometry to Assess Changes in Penile Sensitivity.

J Sex Med 2019 Mar 14;16(3):447-451. Epub 2019 Feb 14.

Division of Urology, Rush University Medical Center, Chicago, IL, USA.

Introduction: Biothesiometry allows for evaluation of penile vibratory sensitivity and can be used as a non-invasive and rapid surrogate test of penile sexual sensitivity. However, no standardized measurement methodology currently exists.

Aim: To describe and optimize a novel, standardized biothesiometry parameter-the penile sensitivity ratio (PSR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2019.01.002DOI Listing
March 2019
1 Read

Effectiveness and safety of fluoxetine for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2019 Feb;98(7):e14481

Department of Traditional Chinese Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: Premature ejaculation (PE) is one of the most common male sexual dysfunctions, which can directly harm men's self-esteem and affect the stability of the relationship between husband and wife. To some extent, PE even affects the harmony and stability of society. So, men's health has gained more and more attention. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201902150-0004
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000014481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407935PMC
February 2019
6 Reads

Which psychosocial variables affect drive the most? Analysis of sexual desire in a group of Italian men.

Int J Impot Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Via dei Marsi 78, 00185, Rome, Italy.

Literature lacks wide studies on variables affecting sexual desire in men. Aim of this study was to explore the role of some psychosocial variables such as quality of life, sexual function, distress, sexual satisfaction, psychological symptoms, emotions, alexithymia, couple adjustment, sexism, dysfunctional beliefs, cognitive schemas, and modes. A self-administered survey reached 450 heterosexual Italian men (age 31. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41443-018-0105-8DOI Listing
February 2019
3 Reads

Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study.

Int J Impot Res 2019 Mar 31;31(2):92-96. Epub 2019 Jan 31.

Bahceci Health Group, Department of Urology, Istanbul, Turkey.

Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE. Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there are limited data about the efficacy and safety of dapoxetine/sildenafil combination therapy for these patients. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41443-019-0122-2
Publisher Site
http://dx.doi.org/10.1038/s41443-019-0122-2DOI Listing
March 2019
14 Reads

Effectiveness comparisons of acupuncture for premature ejaculation: Protocol for a network meta-analysis.

Medicine (Baltimore) 2019 Feb;98(5):e14147

Chinese Medicine Hospital, Changping District, Beijing, China.

Background: As one of the common male sexual dysfunction diseases, the treatment effect of premature ejaculation is often difficult to guarantee. In China, there are many randomized clinical trials that confirm that acupuncture has a good therapeutic effect on premature ejaculation. The aim of this study was to compare the efficacy and safety of acupuncture for premature ejaculation from intravaginal ejaculation latency (IELT), premature ejaculation diagnostic tool (PEDT), Arab premature ejaculation index (AIPE), and premature ejaculation index (IPE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380762PMC
February 2019
4 Reads

[Andrology - Whom and how are patients being referred?]

Rev Int Androl 2019 Jan - Mar;17(1):31-36. Epub 2018 Mar 19.

Serviço de Urologia, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal.

Introduction: Andrology focuses in male sexual and fertility diseases. Its referral should be thoughtful and tailored in order to select the correct cases.

Objectives: The aim of this work was to evaluate the referral to our department and improvement points. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.androl.2017.12.002DOI Listing
March 2018
5 Reads

Differences between ICD-11 MMS and DSM-5 definition of premature ejaculation: a continuation of historical inadequacies and a source of serious misinterpretation by some European Regulatory Agencies (PART 2).

Int J Impot Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Gasthuis, Delft, The Netherlands.

Recently, the ICD-11 for Mortality and Morbidity Statistics (ICD-11-MMS, 2018 Version) has been published with a new definition of premature ejaculation (PE), including a third PE subtype. This definition differs from Diagnostic and Statistical Manual of Mental Disorders (DSM-5) definition of PE. We hereby address the similarities and differences between ICD-11-MMS and DSM-5 definition of PE and call attention to the illogical policy of some European (EU) National Regulatory Agencies to remain with a 1-min cut-off point of ejaculation time for Lifelong, Acquired and Subjective PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41443-018-0108-5DOI Listing
January 2019
10 Reads

Surgical treatment for primary premature ejaculation with an inner condom technique.

Medicine (Baltimore) 2019 Jan;98(3):e14109

Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China.

To explore a novel surgical treatment for primary premature ejaculation using an inner condom technique.A total of 20 males with premature ejaculation, who admitted our andrology clinic from June 2016 to July 2017, were enrolled. By surgery, an inner condom made of acellular dermal matrix (ADM) was transferred to the subcutaneous pocket of the penis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370163PMC
January 2019
12 Reads

Efficacy and safety of behavioral therapy for premature ejaculation: Protocol for a systematic review.

Medicine (Baltimore) 2019 Jan;98(3):e14056

Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine.

Background: Premature ejaculation (PE) is the one of the most prevalent male sexual dysfunction, there has not been specific medicine or therapy for the disease. As an effective treatment for premature ejaculation is a behavioral therapy and is widely used worldwide. The purpose of this study is to evaluate the efficacy and safety of behavioral therapy in patients who suffer from PE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370165PMC
January 2019
3 Reads

Method and design of drug treatment research of subjective premature ejaculation in men differs from that of lifelong premature ejaculation in males: proposal for a new objective measure (part 1).

Int J Impot Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Gasthuis, Delft, The Netherlands.

As lifelong premature ejaculation (PE) and subjective PE are two different PE subtypes, the measurement of their characteristic features requires different objective measures. In this article, we address the differences between lifelong PE and subjective PE, in terms of the extent of variation of sexual performance and propose a new objective measure for research of subjective PE. By considering lifelong PE as a mainly "male" sex disorder and subjective PE as a mainly "man" sex disorder, we show that stopwatch-mediated intravaginal ejaculation latency time (IELT) measurement is most adequate for research of lifelong PE, but inadequate for research of subjective PE. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41443-018-0107-6
Publisher Site
http://dx.doi.org/10.1038/s41443-018-0107-6DOI Listing
January 2019
6 Reads

Pharmacokinetics, Safety, and Tolerability of Multiple Doses of the Novel Oxytocin Receptor Antagonist Cligosiban in Development for Premature Ejaculation: Two Randomized Clinical Trials in Healthy Subjects.

J Sex Med 2019 Feb 4;16(2):213-222. Epub 2019 Jan 4.

Hammersmith Medicines Research Ltd, London, UK.

Background: Cligosiban (formerly IX-01) is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE).

Aim: To investigate the plasma pharmacokinetics, safety, and tolerability of multiple oral doses of cligosiban in healthy male subjects; measure the amount of cligosiban in semen; and evaluate the potential of cligosiban to modulate CYP3A4.

Methods: Both studies were double-blind, placebo-controlled, parallel group designs involving sequential cohorts of 12 subjects each. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2018.11.012DOI Listing
February 2019
10 Reads

Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study.

Int J Impot Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.

This randomized controlled cross-over study aimed to assess the efficacy and safety of glans penis injection with hyaluronic acid (HA) in treating premature ejaculation (PE). A total of 30 patients with PE were randomly allocated into two groups: group 1 (n = 15) which was subjected to glans penis HA injection and group 2 (n = 15) which was injected with saline as a control then both groups were subjected to follow-up at 1 week and 1 month after injection. These subjects were evaluated by intra-vaginal ejaculation latency time (IELT) and the Arabic validated index of premature ejaculation (AIPE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41443-018-0104-9DOI Listing
January 2019
4 Reads

Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis.

BMC Urol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Urology & Nephrology, Ningbo First Hospital, The affiliated hospital of ZheJiang University, 59, Liuting Street, Ningbo, Zhejiang, China.

Background: Paroxetine is one of the selective serotonin reuptake inhibitors (SSRIs) used in the treatment of premature ejaculation (PE). However, this use is not approved in many countries. The purpose of this systematic review and meta-analysis is to review the efficacy and safety of paroxetine for PE patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12894-018-0431-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318994PMC
January 2019
18 Reads

Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation.

World J Mens Health 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Purpose: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.

Materials And Methods: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Read More

View Article

Download full-text PDF

Source
https://wjmh.org/DOIx.php?id=10.5534/wjmh.180062
Publisher Site
http://dx.doi.org/10.5534/wjmh.180062DOI Listing
December 2018
18 Reads

Changes in the Prevalence and Risk Factors of Erectile Dysfunction during a Decade: The Korean Internet Sexuality Survey (KISS), a 10-Year-Interval Web-Based Survey.

World J Mens Health 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.

Purpose: Although the prevalence of erectile dysfunction (ED) can be affected by social changes, this association has not been well evaluated. We aimed to evaluate the prevalence and risk factors of ED through a 10-year-interval web-based survey using the previous database of same group of panels, with same methodology.

Materials And Methods: We sent e-mails and surveyed the panels registered in the Internet survey agency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5534/wjmh.180054DOI Listing
December 2018
5 Reads

Correlation between premature ejaculation and psychological disorders in 270 Chinese outpatients.

Psychiatry Res 2019 02 6;272:69-72. Epub 2018 Dec 6.

Department of Sexual Medicine, Affiliated Yijishan Hospital of Wannan Medical College.

Clinical patients with premature ejaculation(PE) often present with poor psychological state. This study investigated whether there is a difference in the psychological state of PE and non-PE in outpatients, and whether there is a correlation between ejaculatory latency and psychological disorders. We studied demographics informations and psychological indicators for PE patients and control group, including the Self-Rating Anxiety Scale(SAS) and Self-Rating Depression Scale(SDS), Pittsburgh Sleep Quality Index (PSQI) and recorded the ejaculatory latency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2018.12.038DOI Listing
February 2019
2 Reads

Editorial Comment.

Authors:
Alan W Shindel

J Urol 2019 01;201(1):152-153

Department of Urology, University of California-San Francisco, San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.ju.0000550167.66335.79DOI Listing
January 2019
2 Reads

Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross-sectional study.

Andrology 2019 Mar 16;7(2):163-171. Epub 2018 Dec 16.

Sexual Medicine and Andrology Unit, Department of Experimental Clinical and Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.

Background: Premature ejaculation (PE) is present in up to 30% of men with erectile dysfunction (ED).

Objectives: To assess the clinical features of men complaining of both ED and PE (ED-PE) as compared to men reporting only ED or PE.

Materials And Methods: A consecutive series of 4024 men (mean age 51. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/andr.12579DOI Listing
March 2019
3 Reads

Comparative efficacy and safety of phosphodiesterase-5 inhibitors with selective serotonin reuptake inhibitors in men with premature ejaculation: A systematic review and Bayesian network meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13342

Department of Urology, Institute of Urology, West China Hospital of Sichuan University.

Background: We performed the network meta-analysis (NMA) and systematic review involved all evidence from relevant trials to compare the efficiency and safety of various types of selective serotonin reuptake inhibitors (SSRI) and phosphodiesterase-5 inhibitors (PDE5i) in patients with premature ejaculation (PE).

Methods: We conducted comprehensive searches of peer-reviewed and grey literature. PubMed, the Cochrane Library Central Register of Controlled Trials, Embase were searched for randomized controlled trials published up to June 1, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000013342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310608PMC
December 2018
7 Reads

Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents.

J Sex Med 2018 Dec;15(12):1698-1706

Pfizer Global Research and Development, Sexual Health Therapeutic Area, Sandwich, United Kingdom; Ixchelsis Ltd, Sandwich, United Kingdom. Electronic address:

Introduction: Few treatments are available for men with premature ejaculation (PE); oxytocin (OT) receptor antagonism in the central nervous system (CNS) is a potential new approach.

Aim: To determine if cligosiban selectively inhibits human OT receptors, penetrates the CNS, shows pharmacology in the CNS, and effects ejaculatory physiology in pre-clinical systems.

Methods: Experiments complied with United Kingdom legislation and were subject to local ethical review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2018.10.008DOI Listing
December 2018
4 Reads

Psychological burden prediction based on demographic variables among infertile men with sexual dysfunction.

Asian J Androl 2019 Mar-Apr;21(2):156-162

Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

There has been increasing interest in the psycho-socio-relational and sexual disorders of infertility, as the risk of psychological burden among infertile men with sexual dysfunctions is significant. The purpose of this study was to develop and to validate a predictive model to estimate individual psychological burden among infertile men with sexual dysfunction and study the association between them. Comprehensive data were collected for infertile men (n = 480) who sought treatment for infertility in a reproductive medicine center between June 2012 and December 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aja.aja_86_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413542PMC
November 2018
18 Reads

Effect of Thyroid Hormone Derangements on Sexual Function in Men and Women.

Sex Med Rev 2018 Nov 17. Epub 2018 Nov 17.

Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA; Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Introduction: Sexual dysfunction affects many people, with 33‒60% of women reporting sexual dysfunction and 8‒52% of men with erectile dysfunction or premature ejaculation. In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest.

Aim: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sxmr.2018.09.005DOI Listing
November 2018
15 Reads

Premature ejaculation in primary care: communication strategies versus usual care for male patients consulting for a sexual, urogenital or psychological reason - GET UP: study protocol for a cluster randomised controlled trial.

Trials 2018 Nov 12;19(1):622. Epub 2018 Nov 12.

Département de Médecine Générale, UFR Sciences Médicales, Université de Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux cedex, France.

Background: Premature ejaculation (PE) is the most common sexual dysfunction among men. According to patients, the general practitioner (GP) is the appropriate professional with whom to discuss this issue. However, few patients receive the medical help needed because GPs find it difficult to talk to their patients about sex. Read More

View Article

Download full-text PDF

Source
https://trialsjournal.biomedcentral.com/articles/10.1186/s13
Publisher Site
http://dx.doi.org/10.1186/s13063-018-2947-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233366PMC
November 2018
12 Reads

Acellular dermal matrix in premature ejaculation: A preliminary study.

Medicine (Baltimore) 2018 Nov;97(45):e13135

Department of Urology, Peking University People's Hospital.

Background: To investigate the efficacy of acellular dermal matrix in penis augmentation (ADMPA) for premature ejaculation (PE).

Methods: A total of 39 patients treated with ADM in penis augmentation from June 2014 to December 2017 were evaluated. Detailed evaluations on PE were conducted before operation and at the 6-month and 2-year follow-up visits after operation. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201811090-0006
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250443PMC
November 2018
14 Reads

The antioxidant compounds isolated from the fruits of chinese wild raspberry Rubus Chingii Hu.

Nat Prod Res 2018 Oct 22:1-4. Epub 2018 Oct 22.

a Department of Applied Chemistry , Xi'an University of Technology , Xi'an , China.

Raspberry, the fruit of Rubus Chingji Hu, is a widely distributed economic staple food in China. It has long been used as a traditional medicine in mainland China to treat kidney enuresis, nocturnal emission and premature ejaculation in clinic. In this paper, six known compounds (1 - 6) were purified from the fruits of Rubus chingji. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14786419.2018.1504046DOI Listing
October 2018
19 Reads

Pharmacokinetics, Safety, and Tolerability of Single Oral Doses of a Novel Oxytocin Receptor Antagonist-Cligosiban-in Development for Premature Ejaculation: Three Randomized Clinical Trials in Healthy Subjects.

J Sex Med 2018 Nov 16;15(11):1547-1557. Epub 2018 Oct 16.

Worldwide Clinical Trials, Early Phase Services LLC, San Antonio, Texas, USA.

Introduction: Cligosiban is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE).

Aim: Three clinical studies investigated the pharmacokinetics (including effect of food and formulation), central penetration, safety, and tolerability of single oral doses of cligosiban in healthy subjects.

Methods: Study 1 was a double-blind, randomized, placebo-controlled, crossover design in 3 cohorts of 10 subjects each. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17436095183116
Publisher Site
http://dx.doi.org/10.1016/j.jsxm.2018.09.006DOI Listing
November 2018
11 Reads

Milnacipran for Postcoital Cephalgia and Premature Ejaculation.

Authors:
Ahmed Naguy

Am J Ther 2018 Sep 25. Epub 2018 Sep 25.

Al-Manara Centre, Kuwait Centre for Mental Health (KCMH), Kuwait City, Kuwait.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00045391-900000000-9855
Publisher Site
http://dx.doi.org/10.1097/MJT.0000000000000863DOI Listing
September 2018
11 Reads
1.130 Impact Factor

[Effects of drug use and anxiety on premature ejaculation in a sample of Spanish drug addicts].

Rev Int Androl 2018 Oct - Dec;16(4):159-166. Epub 2018 Mar 30.

Departamento de Fisiología, Facultad de de la Actividad Física y del Deporte, Universidad de Granada, Granada, España.

Introduction: Premature ejaculation may be due to many factors and one of them may be drug use.

Aims: The main objective of this study is to show how drug abuse affects the ejaculatory response, keeping in mind the different substances consumed, the level of anxiety and the period of withdrawal.

Method: Two samples were used, one for men who were addicted to drugs (N=925) and one of non-consumers (N=82). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1698031X183002
Publisher Site
http://dx.doi.org/10.1016/j.androl.2017.09.004DOI Listing
March 2018
8 Reads

Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis.

Ann Saudi Med 2018 Sep-Oct;38(5):366-375

Dr. Jing Li, Department of Urology,, Xinxiang Central Hospital,, Xinxiang 453000, China, T: +8613462286403, ORCID: http:// orcid.org/0000-0003-3030-354X.

Background: The safety and efficacy of dapoxetine for the treatment of premature ejaculation (PE) is still controversial. Thus, we decided to conduct a meta-analysis using trial sequential analysis (TSA) to determine the sufficiency of conclusions.

Objective: Evaluate the efficacy and safety of dapoxetine in the treatment of patients with PE and assess the reliability of the findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5144/0256-4947.2018.366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180218PMC
January 2019
5 Reads

5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation.

Rev Int Androl 2018 Sep 25. Epub 2018 Sep 25.

Andrology & STDs Department, Cairo University, Egypt.

Introduction And Objectives: Lifelong premature ejaculation (LPE) is identified as the inability to delay ejaculation for more than 1min after vaginal penetration occurring on all or almost all sexual experiences together with feelings of frustration of both the patient and his partner with avoidance of sexual intimacy. Recently, a role for (HTR1A)-C (1019) G gene polymorphism in patients with LPE was postulated.

Materials And Methods: Three hundred and fifty participants were prospectively enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.androl.2018.07.004DOI Listing
September 2018
6 Reads

The Relationship Between Body Image and Sexual Functioning Among Gay and Bisexual Men.

J Homosex 2018 Sep 28:1-26. Epub 2018 Sep 28.

b Department of Family Relations and Applied Nutrition , The University of Guelph, Guelph , Ontario , Canada.

Gay and bisexual men report high body dissatisfaction compared to heterosexual counterparts, but no studies to date have examined how this may impact their sexual functioning. The present study investigated body image domains as predictors of sexual functioning problems (inhibited desire, erectile dysfunction, and premature ejaculation) among an online community sample of 185 gay and bisexual men, ages 18-40. Participants reported moderate to high body image satisfaction and sexual functioning consistent with previous literature with nonclinical male samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00918369.2018.1519301DOI Listing
September 2018
3 Reads

Editorial to the paper entitled "pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis".

Authors:
Ali Atan

Int Urol Nephrol 2018 Nov 21;50(11):2015-2016. Epub 2018 Sep 21.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-1988-5
Publisher Site
http://dx.doi.org/10.1007/s11255-018-1988-5DOI Listing
November 2018
8 Reads

Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis.

Int Urol Nephrol 2018 Nov 17;50(11):1939-1948. Epub 2018 Sep 17.

Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Purpose: The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for premature ejaculation (PE).

Methods: A systematic literature search of MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for Systematic Reviews was performed on 1 March 2018. Intravaginal ejaculation latency time (IELT) was the main outcome. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-1984-9
Publisher Site
http://dx.doi.org/10.1007/s11255-018-1984-9DOI Listing
November 2018
20 Reads