175,141 results match your criteria Premature Ejaculation


The Influence of Sleep Apnea on 24-hour and Nocturnal ECG and Blood Pressure Parameters in Patients with Acute Heart Failure.

Med Princ Pract 2018 Dec 11. Epub 2018 Dec 11.

Objective: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF).

Methods: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Read More

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December 2018
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Establishment of a Mouse Model of Premature Ovarian Failure Using Consecutive Superovulation.

Cell Physiol Biochem 2018 7;51(5):2341-2358. Epub 2018 Dec 7.

Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing,

Background/aims: This study investigated the effect of consecutive superovulation on the ovaries and established a premature ovarian failure (POF) model in mice.

Methods: The mouse POF model was induced by 5-15 consecutive superovulation treatments with pregnant mare serum gonadotropin (PMSG), human chorionic gonadotropin (HCG) and prostaglandin F2α (PGF2α). Normal adult mice were compared with mice displaying natural ovarian aging. Read More

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December 2018

Brief reaching training with "sticky mittens" in preterm infants: Randomized controlled trial.

Hum Mov Sci 2018 Dec 8;63:138-147. Epub 2018 Dec 8.

Physical Therapy Section, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil. Electronic address:

Objective: To examine whether a brief reaching training with sticky mittens was effective to improve reaching behavior in newly reaching preterm infants.

Methods: In this randomized controlled trial, twenty four 5-month-old (±16-week-old corrected age) preterm infants were randomly allocated into experimental or control groups. Infants were assessed three times in a single session: pretraining (immediately before training), posttraining (immediately after training), and retention (4 min after the posttraining). Read More

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December 2018

Clinical and echocardiography predictors of response to inhaled nitric oxide in hypoxic preterm neonates.

J Paediatr Child Health 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Aim: To evaluate the clinical and echocardiography modulators of treatment response in hypoxemic preterm infants exposed to inhaled nitric oxide (iNO).

Methods: In this multicentre retrospective study, clinical parameters, including oxygenation, ventilation and haemodynamics, were collected for preterm infants <36 weeks gestation before and 2 h after initiation of iNO for acute hypoxemia. Comprehensive echocardiography, performed near the time iNO initiation, was analysed by experts blind to the clinical course. Read More

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December 2018

Probiotics can stimulate initial head growth in premature infants.

Authors:
Olivier Claris

Acta Paediatr 2019 Jan;108(1):10-11

Department of Neonatology, Hospices Civils de Lyon, Hôpital Femme Mère Enfants, Claude Bernard University, Lyon, France.

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January 2019

A meta-analysis of neurodevelopmental outcomes at 4-10 years in children born at 22-25 weeks gestation.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

University of Ottawa, Faculty of Medicine, Ottawa, Canada.

Aim: To update our meta-analysis on neurodevelopmental disability rates in children born at 22-25 weeks gestation. The main outcome measure was rates of neurodevelopmental disability in survivors at age 4-10 years.

Methods: We used a peer-reviewed electronic and grey search to identify articles. Read More

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December 2018

Developmental defects of enamel in the deciduous incisors of infants born preterm: prospective cohort.

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Oral Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Objective: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake, and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants.

Subjects And Methods: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Read More

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December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

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December 2018

Accessing free quality health care services and premature death.

Int J Health Plann Manage 2018 Dec 11. Epub 2018 Dec 11.

Petroleum Industry Health Organization Headquarters, Tehran, Iran.

Background: The type of health insurance may affect the likelihood of mortality of insured people. We conducted this study to determine if accessing free quality health care services could decrease the premature mortality of people in a developing country.

Methods: In a multicenter cross sectional study, "years-life-lost" (YLL) due to premature death was evaluated in 202 671 insured people residing in six large regions in Iran. Read More

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December 2018

Practice variation among Dutch paediatricians in palivizumab prescription rates: the importance of parental counselling approach.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatrics, Isala, Zwolle.

Aim: To investigate differences in palivizumab prescription rates between Dutch paediatricians, and the role of parent counselling in this practice variation.

Methods: A retrospective chart review of premature infants <32 weeks of gestation, aged
Results: We included 208 patients, 133 (64%) of whom received palivizumab. Read More

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December 2018

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

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December 2018

Detection of extracellular vesicles in the mouse vaginal fluid: Their delivery of sperm proteins that stimulate capacitation and modulate fertility.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biological Sciences, University of Delaware, Newark, Delaware.

Extracellular vesicles (EVs) were isolated by ultracentrifugation of vaginal luminal fluid (VLF) from superovulated mice and identified for the first time using transmission electron microscopy. Characterized by size and biochemical markers (CD9 and HSC70), EVs were shown to be both microvesicular and exosomal and were dubbed as "Vaginosomes" (VGS). Vaginal cross-sections were analyzed to visualize EVs in situ: EVs were present in the lumen and also embedded between squamous epithelial and keratinized cells, consistent with their endogenous origin. Read More

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December 2018

Model that predicted death or disabilities in premature infants was valid at seven years of age.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Neonatologist. 12 de Octubre University Hospital, Madrid, Spain.

Aim: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.

Methods: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes. Read More

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December 2018

Evaluation of a high-sensitivity cardiac troponin I assay compared to a first-generation cardiac troponin I assay in Doberman Pinschers with and without dilated cardiomyopathy.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Clinic of Small Animal Medicine, LMU University, Munich, Germany.

Background: Echocardiography and 24-hour ECG are the gold standard tests to diagnose dilated cardiomyopathy (DCM) in Doberman Pinschers (DP), but myocardial damage might be detected earlier using a high-sensitivity cardiac troponin I (hs-cTnI) assay.

Objective: To evaluate and compare an hs-cTnI assay (Advia Centaur TnI-Ultra assay) with a conventional cTnI assay in DP with different stages of DCM and in healthy DP.

Animals: Three hundred forty-five examinations from 162 DP with and 179 DP without DCM. Read More

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December 2018

The Role of Caspase-3, Apoptosis-Inducing Factor, and B-cell Lymphoma-2 Expressions in Term Premature Rupture of Membrane.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):733-739. Epub 2018 Dec 7.

Department of Public Health, Dhyana Pura University, Bali, Indonesia.

Objective:  To determine the role of caspase-3, apoptosis-inducing factor (AIF), and B-cell lymphoma-2 (Bcl-2) expressions in term premature rupture of membrane (PROM).

Methods:  An analytic observational study with case-control design was conducted, involving 52 subjects (37-42 weeks of gestation) who were divided into 2 groups: 26 cases of term delivery with PROM, and 26 controls of term delivery without PROM. The expressions of caspase-3, AIF, and Bcl-2 in the amniotic membrane were determined by immunohistochemistry. Read More

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December 2018

Heart involvement in patients with myotonic dystrophy type 2.

Acta Neurol Belg 2018 Dec 7. Epub 2018 Dec 7.

Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of Belgrade, 6, Dr Subotica Street, Belgrade, 11000, Serbia.

Myotonic dystrophy type 2 (DM2) is a slowly progressive, autosomal-dominant disease. This is a multisystemic disorder that affects the heart, which is one of the main causes of morbidity and mortality in DM2. The aim of the study was to define cardiac impairments in patients with DM2 and its association with sociodemographic and clinical features of patients. Read More

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December 2018

Periodontal Ehlers-Danlos syndrome is associated with leukoencephalopathy.

Neurogenetics 2018 Dec 8. Epub 2018 Dec 8.

Department of Child Neurology and Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain. Read More

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December 2018

Functional relationship between p53 and RUNX proteins.

J Mol Cell Biol 2018 Dec 11. Epub 2018 Dec 11.

Cancer Science Institute of Singapore, National University of Singapore, Singapore - 117599.

RUNX genes belong to a three-membered family of transcription factors, which are well established as master regulators of development. Of them, aberrations in RUNX3 expression are frequently observed in human malignancies primarily due to epigenetic silencing which is often overlooked. At the G1 phase of the cell cycle, RUNX3 regulates the restriction (R)-point, a mechanism that decides cell cycle entry. Read More

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December 2018

[Prevalence of genital Chlamydia trachomatis infection in women attending in the National Institute of Perinatology from Mexico City].

Rev Chilena Infectol 2018 Aug;35(4):371-376

Laboratorio de Biología Molecular, Departamento de Infectología, Instituto Nacional de Perinatología, Mexico.

Background: Endocervical infection by Chlamydia trachomatis is considered one of the leading causes of infertility worldwide. During pregnancy, it can lead to serious complications such as premature rupture of membranes and premature births.

Aim: To determine the prevalence of genital infection by C. Read More

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E-Health Interventions for Adult and Aging Population With Intellectual Disability: A Review.

Front Psychol 2018 26;9:2323. Epub 2018 Nov 26.

Facultad de Enfermería y Nutrición, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.

To answer the question about which e-health and e-therapy applications are being used with people with intellectual disabilities, we searched the PsycINFO, Medline, PubMed, ERIC, CINAHL, Scopus, Web of Science, and Cochrane databases. This is an extensive search. Inclusion criteria were academic journals and any design type that addressed the topic of interest. Read More

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November 2018

Whole-Genome Sequences of Six Listeria monocytogenes Strains Isolated from Food.

Microbiol Resour Announc 2018 Oct 11;7(14). Epub 2018 Oct 11.

Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.

Here, we report the whole-genome sequences of six Listeria monocytogenes strains isolated from meat and milk products in Switzerland. All of these strains carry premature stop codons or amino acid deletions in . Read More

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October 2018

Atrial Septal Defects Accelerate Pulmonary Hypertension Diagnoses in Premature Infants.

Front Pediatr 2018 23;6:342. Epub 2018 Nov 23.

Department of Pediatrics, Emory University, Atlanta, GA, United States.

Between 4 and 16% of extremely premature infants have late pulmonary hypertension (PH) (onset >30 days of life), and infants with PH have a higher risk of tracheostomy and death. Atrial septal defects (ASD) increase pulmonary blood flow and may promote PH in at-risk infants. The objective of this study was to determine if infants with ASD develop PH sooner than those without ASD. Read More

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November 2018

Skeletal muscle metabolism in rats with low and high intrinsic aerobic capacity: Effect of aging and exercise training.

PLoS One 2018 11;13(12):e0208703. Epub 2018 Dec 11.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

Purpose: Exercise training increases aerobic capacity and is beneficial for health, whereas low aerobic exercise capacity is a strong independent predictor of cardiovascular disease and premature death. The purpose of the present study was to determine the metabolic profiles in a rat model of inborn low versus high capacity runners (LCR/HCR) and to determine the effect of inborn aerobic capacity, aging, and exercise training on skeletal muscle metabolic profile.

Methods: LCR/HCR rats were randomized to high intensity low volume interval treadmill training twice a week or sedentary control for 3 or 11 months before they were sacrificed, at 9 and 18 months of age, respectively. Read More

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December 2018

Hydrogen Sulfide Regulates Energy Production to Delay Leaf Senescence Induced by Drought Stress in .

Front Plant Sci 2018 23;9:1722. Epub 2018 Nov 23.

School of Life Science, Shanxi University, Taiyuan, China.

Hydrogen sulfide (HS) is a novel gasotransmitter in both mammals and plants. HS plays important roles in various plant developmental processes and stress responses. Leaf senescence is the last developmental stage and is a sequential degradation process that eventually leads to leaf death. Read More

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November 2018

Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.

PLoS Genet 2018 Dec 10;14(12):e1007844. Epub 2018 Dec 10.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America.

Spinocerebellar ataxia type 11 (SCA11) is a rare, dominantly inherited human ataxia characterized by atrophy of Purkinje neurons in the cerebellum. SCA11 is caused by mutations in the gene encoding the Serine/Threonine kinase Tau tubulin kinase 2 (TTBK2) that result in premature truncations of the protein. We previously showed that TTBK2 is a key regulator of the assembly of primary cilia in vivo. Read More

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December 2018

Type 2 Diabetes Mellitus is Associated with Carotid Artery Plaques in Patients with Premature Coronary Heart Disease.

Rev Invest Clin 2018 ;70(6):301-309

Department of Nephrology, Laboratory of Renal Physiopathology. Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: In subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events.

Objective: The objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients.

Methods: Premature CHD was considered before the age of 55 years in men and before 65 in women. Read More

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January 2018

MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner.

Oncogene 2018 Dec 7. Epub 2018 Dec 7.

Department of Medical Genetics, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.

MDM2 (Murine double minute 2) acts as a key repressor for p53-mediated tumor-suppressor functions, which includes cellular senescence. We found that MDM2 can promote cellular senescence by modulating WRN stability. Werner syndrome (WS), caused by mutations of the WRN gene, is an autosomal recessive disease, which is characterized by premature aging. Read More

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December 2018

[The 'missing' of the duodenum].

Khirurgiia (Mosk) 2018 (11):66-67

Chair of faculty-based surgery #2, Sechenov First Moscow State Medical University, Moscow, Russia.

The article presents the outcome in patient with duodenal congenital abnormality caused by defective intrauterine rotation of the intestinal tube with premature turn of back intestine. Read More

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January 2018

The Use of Microplates for Internal Fixation of Comminuted Mandibular Fractures.

Ann Plast Surg 2019 Jan;82(1):55-61

Department of Plastic Surgery, Kyung Hee University Medical Center.

Background: Although clinical trials have successfully applied microplates for the internal fixation of single or double isolated mandibular fractures, the use of microplate systems in comminuted mandibular fractures is not widely accepted. This study aimed to evaluate the use of microplates for internal fixation of comminuted mandible fractures and to discuss their applicability.

Methods: Fourteen patients with comminuted mandibular fractures (10 at a single region, 3 at 2 regions, and 1 at 4 regions) were treated with open reduction and internal fixation using 0. Read More

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January 2019

Family Presence During Electroconvulsive Therapy.

J ECT 2018 Dec 7. Epub 2018 Dec 7.

Peter James Centre, Eastern Health, Victoria, Australia.

Background: The practice of electroconvulsive therapy (ECT) is often hampered by stigma and myths prevailing among patients and families. Family attendance at ECT has not been systematically studied.

Methods: From January 2017 to May 2018, 69 consecutive patients were approached for family attendance at ECT. Read More

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December 2018

Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations.

Anticancer Drugs 2018 Dec 6. Epub 2018 Dec 6.

Nencki Institute of Experimental Biology.

Human colon cancer C85 cell response to methotrexate has been documented previously to take on a form of reversible premature senescence. Seeking genomic aberrations encompassing candidate genes whose functional impairment could determine such a response to the drug, an array Comparative Genomic Hybridization method was applied, complemented by expression microarray data set searching. In the C85 cell genome, only short aberrations were identified, classified as focal chromosomal aberrations. Read More

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December 2018

Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine (CC, KR, YG, ZF, MM); Department of Hematology (AP-P); Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL (SJC).

: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. Read More

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November 2018

Central diabetes insipidus: A rare complication of IVH in a very low birth weight preterm infant.

J Neonatal Perinatal Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA.

A 710 g male infant was born at a referring hospital at a gestational age of 23 weeks and 2 days via vaginal delivery and was transferred to our facility at 14 days of age. His delivery was complicated by the breech presentation with difficult head extraction. The infant's initial course was significant for respiratory distress syndrome, grade III-IV intraventricular hemorrhage (IVH), acute kidney injury, and large PDA. Read More

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December 2018

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation.

Aging (Albany NY) 2018 Dec 8. Epub 2018 Dec 8.

IVIRMA New Jersey, Basking Ridge, NJ 07920, USA.

An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject. Interestingly, when there is discrepancy between the predicted age and chronologic age (age acceleration or "AgeAccel"), patients are at risk for morbidity and mortality. Identification of infertile patients at risk for accelerated reproductive senescence may permit preventative action. Read More

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December 2018

Rare Copy Number Variants (CNVs) in the Genome of Chinese Female Children and Adolescents with Turner Syndrome.

Biosci Rep 2018 Dec 7. Epub 2018 Dec 7.

Guangzhou Women and Children's Medical Center, Guangzhou, China

Turner syndrome (TS) is a congenital disease caused by complete or partial loss of one X chromosome. Low bone mineral status is a major phenotypic characteristic of TS that can not be fully explained by X chromosome loss, suggesting other autosomal-linked mutations may also exist. Therefore, this study aimed to detect potential genetic mutations in TS through examination of copy number variation (CNV). Read More

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December 2018

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy.

EMBO Mol Med 2018 Dec 10. Epub 2018 Dec 10.

Folkhälsan Research Center, Helsinki, Finland

Alternative oxidase (AOX) is a non-mammalian enzyme that can bypass blockade of the complex III-IV segment of the respiratory chain (RC). We crossed a AOX transgene into RC complex III (cIII)-deficient knock-in mice, displaying multiple visceral manifestations and premature death. The homozygotes expressing AOX were viable, and their median survival was extended from 210 to 590 days due to permanent prevention of lethal cardiomyopathy. Read More

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December 2018

Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: From biological evidence to clinical application.

Cancer Treat Rev 2018 Dec 1;72:65-77. Epub 2018 Dec 1.

Fertility Clinic, CUB-Hôpital Erasme and Research Laboratory on Human Reproduction, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with cancer patients. In women diagnosed during their reproductive years, the possible occurrence of chemotherapy-induced premature ovarian insufficiency (POI) is of particular concern being associated with important menopause-related symptoms, psychosocial issues as well as infertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been studied to reduce the gonadotoxic impact of chemotherapy thus diminishing the chance of developing POI. Read More

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December 2018

Outcomes of Pregnancy in Recipients of Liver Transplants.

Clin Gastroenterol Hepatol 2018 Dec 6. Epub 2018 Dec 6.

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, UK. Electronic address:

Background & Aims: Despite increasing reports of pregnancy in women who received liver transplants, it is not clear how transplantation and immunosuppression affect pregnancy. We collected data from liver transplant recipients who became pregnant on immunosuppression regimens, pregnancy management, graft morbidity, and outcomes of mothers and neonates.

Methods: We searched the liver transplant database in Birmingham, United Kingdom, for women who reported pregnancy after liver transplantation from August 1986 through May 2016. Read More

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December 2018

Features of Patients Aged 80 Years or Older with Embolic Stroke of Undetermined Source.

J Stroke Cerebrovasc Dis 2018 Oct 24. Epub 2018 Oct 24.

Division of Neurology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Background: Embolic stroke of undetermined source has not been thoroughly investigated in older patients. In this study, we investigated the features of this condition in patients greater than or equal to 80 years of age.

Methods: All patients with acute ischemic stroke in our hospital underwent diffusion-weighted imaging, magnetic resonance angiography, T2-weighted imaging, and fluid-attenuated inversion recovery sequence imaging. Read More

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October 2018

Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers.

J Pediatr 2018 Oct 24. Epub 2018 Oct 24.

Division of Endocrinology Department of Pediatrics, Medical School, University of Patras, Patra, Greece. Electronic address:

Objectives: To assess whether the serum levels of anti-Müllerian hormone (AMH) are increased in girls with premature adrenarche because they are at a higher risk of developing polycystic ovary syndrome (PCOS) later in life.

Study Design: We measured serum levels of AMH, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone binding globulin, androstenedione, and 17-hyroxyprogesterone in 89 girls with premature adrenarche aged 6.98 ± 1. Read More

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October 2018

A Comparison of Developmental Outcomes of Adolescent Neonatal Intensive Care Unit Survivors Born with a Congenital Heart Defect or Born Preterm.

J Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Research Institute of the McGill University Health Centre, Montreal, Québec, Canada; School of Physical and Occupational Therapy, McGill University, Montreal, Québec, Canada; Department of Pediatrics, Division of Child Neurology, McGill University, Montreal, Québec, Canada. Electronic address:

Objective: To compare cognitive, motor, behavioral, and functional outcomes of adolescents born with a congenital heart defect (CHD) and adolescents born preterm.

Study Design: Adolescents (11-19 years old) born with a CHD requiring open-heart surgery during infancy (n = 80) or born preterm ≤29 weeks of gestational age (n = 128) between 1991 and 1999 underwent a cross-sectional evaluation of cognitive (Leiter International Performance Scale-Revised), motor (Movement Assessment Battery for Children-II), behavioral (Strengths and Difficulties Questionnaire), and functional (Vineland Adaptive Behavior Scale-II) outcomes. Independent samples t tests and Pearson χ or Fisher exact tests were used to compare mean scores and proportions of impairment, respectively, between groups. Read More

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December 2018

Mid-term outcomes after percutaneous interventions in coronary bifurcations.

Int J Cardiol 2018 Dec 2. Epub 2018 Dec 2.

Department of Cardiology, Clinical Center of Serbia, University of Belgrade, Serbia.

Background: The optimal treatment of patients undergoing percutaneous coronary interventions (PCI) for lesions located at coronary bifurcations is still debated.

Methods: Data on 5036 consecutive patients who underwent PCI on coronary bifurcation at 17 major coronary intervention centers between January 2012 and December 2014 were collected.

Results: Follow-up at a median 18 months (IQR 11-28) was available for 4506 patients (89%). Read More

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December 2018

Investigating the effect of anticipating a startling acoustic stimulus on preparatory inhibition.

Neurophysiol Clin 2018 Dec 5. Epub 2018 Dec 5.

Institute of Neuroscience, Université catholique de Louvain, 53, Avenue Mounier, COSY- B1.53.04, 1200 Brussels, Belgium.

Objectives: Motor-evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) show a profound suppression when elicited during the instructed-delay of reaction time (RT) tasks. One predominant hypothesis is that this phenomenon, called "preparatory inhibition", reflects the operation of processes that suppress motor activity to withhold prepared (but delayed) responses, a form of impulse control. In addition, a startling acoustic stimulus (SAS) - a loud and narrow sound - can trigger the release of prepared responses in RT tasks. Read More

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December 2018

Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia.

J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.

Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More

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February 2019

Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study.

Schizophr Res 2018 Dec 5. Epub 2018 Dec 5.

Research Unit of Psychiatry, Institute of Clinical Research, University of Southern Denmark, Sdr. Boulevard 29, 5000 Odense C, Denmark.

Introduction: People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality.

Method: A register-based retrospective nested case-control study was conducted, identifying incident cases of cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), cancer and diabetes, as well as mortality due to these diseases, across the lifespan in schizophrenia. Read More

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December 2018

Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018.

Can J Cardiol 2018 Dec;34(12):1553-1563

Research Institute of the McGill University Health Centre, Royal Victoria Hospital, Montréal, Quebec, Canada; Department of Medicine, McGill University, Montréal, Quebec, Canada.

Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of the approximately 145,000 Canadians estimated to have FH, most are undiagnosed. Herein, we provide an update of the 2014 Canadian Cardiovascular Society position statement on FH addressing the need for case identification, prompt recognition, and treatment with statins and ezetimibe, and cascade family screening. Read More

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December 2018

Pregnancy induced hypertension and outcomes in early and moderate preterm infants.

Pregnancy Hypertens 2018 Oct 9;14:68-71. Epub 2018 Aug 9.

Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.

Study Design: Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity. Read More

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October 2018

Cligosiban, A Novel Brain-Penetrant, Selective Oxytocin Receptor Antagonist, Inhibits Ejaculatory Physiology in Rodents.

J Sex Med 2018 Dec;15(12):1698-1706

Pfizer Global Research and Development, Sexual Health Therapeutic Area, Sandwich, United Kingdom; Ixchelsis Ltd, Sandwich, United Kingdom. Electronic address:

Introduction: Few treatments are available for men with premature ejaculation (PE); oxytocin (OT) receptor antagonism in the central nervous system (CNS) is a potential new approach.

Aim: To determine if cligosiban selectively inhibits human OT receptors, penetrates the CNS, shows pharmacology in the CNS, and effects ejaculatory physiology in pre-clinical systems.

Methods: Experiments complied with United Kingdom legislation and were subject to local ethical review. Read More

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December 2018

Prognosis and future developments in vasculitis.

Best Pract Res Clin Rheumatol 2018 02 22;32(1):148-165. Epub 2018 Sep 22.

Department of Medicine, Imperial College London, United Kingdom.

The prognosis of ANCA-associated vasculitis has been transformed in recent years. Once it was a set of invariably acute and fatal conditions, but these disorders are currently considered to be chronic diseases. This change is largely attributable to earlier diagnosis and the careful application of immunotherapeutics. Read More

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February 2018