247 results match your criteria Premalignant Lesions of the Endometrium


Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210;

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. Read More

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http://dx.doi.org/10.1073/pnas.1814506116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410785PMC
February 2019
10 Reads
9.809 Impact Factor

Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma

Asian Pac J Cancer Prev 2018 Aug 24;19(8):2291-2297. Epub 2018 Aug 24.

Department of Pathology, Faculty of Medicine, Zagazig University, Cairo, Egypt. Email:

Background: Endometrial carcinomas are common gynecologic malignancies worldwide. In Egypt they represent 2.6 %. Read More

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http://dx.doi.org/10.22034/APJCP.2018.19.8.2291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171378PMC
August 2018
3 Reads

Expression of Laminin Receptor 1 in Normal, Hyperplastic, and Malignant Endometrium.

Int J Gynecol Pathol 2018 Jul 18. Epub 2018 Jul 18.

Department of Obstetrics and Gynecology, Kudret International Hospital (M.K.) Department of Obstetrics and Gynecology, Ankara Education and Research Hospital (Z. Kurdoglu), Ankara Department of Obstetrics and Gynecology, Medicana Konya (Z. Kucukaydin) Department of Pathology, Konya Training and Research Hospital (Y.U.), Konya Department of Pathology, Yuzuncu Yil University School of Medicine, Van (G.B., S.O.), Turkey.

Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed. Read More

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http://Insights.ovid.com/crossref?an=00004347-900000000-9917
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http://dx.doi.org/10.1097/PGP.0000000000000535DOI Listing
July 2018
15 Reads

Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice.

Toxicol Pathol 2018 07 12;46(5):574-596. Epub 2018 Jun 12.

2 Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epithelial phenotypes over time following neonatal treatment with the synthetic estrogen diethylstilbestrol (DES) or the soy phytoestrogen genistein (GEN) in female CD-1 mice. Read More

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http://dx.doi.org/10.1177/0192623318779326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027618PMC
July 2018
14 Reads

Clinicopathological Characteristics and Mutation Status of Endometrial Mucinous Metaplasia and Carcinoma.

Anticancer Res 2018 05;38(5):2779-2786

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Background/aim: Mucinous metaplasia of the endometrium occurs as a spectrum of epithelial alterations ranging from the formation of simple, tubular glands to architecturally complex glandular proliferation with intraglandular papillary projection and cellular tufts. Endometrial mucinous metaplasia often presents a diagnostic challenge in endometrial curettage.

Materials And Methods: We analyzed the clinicopathological characteristics and the mutation status for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial mucinous metaplasia. Read More

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http://dx.doi.org/10.21873/anticanres.12521DOI Listing
May 2018
4 Reads

Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens.

Virchows Arch 2018 Jun 14;472(6):907-917. Epub 2018 Feb 14.

Department of Pathology, The University of Hong Kong, Block T, Queen Mary Hospital, 102 Pok Fu Lam Road, Pok Fu Lam, Hong Kong SAR.

Benign proliferations that mimic malignancies are commonly encountered during the course of assessment of small and fragmented endometrial samples. Although benign, endometrial epithelial metaplasias often coexist with premalignant or malignant lesions causing diagnostic confusion. The difficulty with mucinous metaplasia lies in its distinction from atypical mucinous glandular proliferations and mucinous carcinomas, which are associated with significant interobserver variability. Read More

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http://dx.doi.org/10.1007/s00428-018-2314-4DOI Listing
June 2018
14 Reads

The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions.

Med Hypotheses 2018 Jan 13;110:80-82. Epub 2017 Nov 13.

Gynecology Department, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy. Electronic address:

Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Read More

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http://dx.doi.org/10.1016/j.mehy.2017.11.006DOI Listing
January 2018
8 Reads

Uterine Prolapse: Should Hysterectomy Specimens be Subjected for Histopathological Examination?

J Midlife Health 2017 Oct-Dec;8(4):179-182

Department of Obstetrics and Gynaecology, Christian Medical College, Ludhiana, Punjab, India.

Context: Uterine prolapse accounts for one of the common gynecological problems in India. The excised uterus is not expected to have any pathological finding other than atrophic endometrium and may be an ulcer because of the prolapse.

Aims: The aim of this study is to assess the hysterectomy specimen for unsuspected pathology. Read More

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http://dx.doi.org/10.4103/jmh.JMH_80_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753499PMC
January 2018
14 Reads

Endometriosis-associated Ovarian Cancers.

Clin Obstet Gynecol 2017 12;60(4):711-727

*Department of Obstetrics and Gynaecology, OVCARE, Robert HN Ho Research Centre, Vancouver, British Columbia, Canada †Department of Obstetrics and Gynaecology, BC Women's Centre for Pelvic Pain and Endometriosis, University of British Columbia, Vancouver, British Columbia, Canada.

Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions are in fact the precursors for endometriosis-associated cancers. Herein, we will explore the relationship between endometriosis and ovarian carcinomas, similarities between the premalignant lesions and their cancerous counterparts, and the potential role of mutations and the ovarian microenvironment that may contribute to malignant transformation. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000320DOI Listing
December 2017
5 Reads

Hysterscopic Resection of Premalignant and Malignant Endometrial Polyps: Is it a Safe Alternative to Hysterectomy?

J Minim Invasive Gynecol 2017 Nov - Dec;24(7):1200-1203. Epub 2017 Aug 9.

Division of Gynecologic Oncology, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Obstetrics and Gynecology, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Study Objective: The standard treatment of endometrial cancer (EC) and complex atypical hyperplasia (CAH) is hysterectomy with or without adnexectomy. In the last decade several centers have attempted to perform hysteroscopic resection of malignant and premalignant polyps as an alternative to hysterectomy. In the present study we evaluated the safety of this procedure in regard to residual uterine pathology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15534650173044
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http://dx.doi.org/10.1016/j.jmig.2017.08.002DOI Listing
April 2018
13 Reads

The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India.

Acta Cytol 2017 25;61(3):199-206. Epub 2017 May 25.

Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.

Introduction: Glandular lesions of the female genital tract (FGT) are quite uncommon compared to squamous lesions. Their cytological diagnosis is difficult because of their architectural and cytological complexity, as well as the lack of experience of many cytopathologists in this field. The aim of this study was to determine the significance of Papanicolaou (Pap) smears in the diagnosis of glandular FGT lesions. Read More

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http://dx.doi.org/10.1159/000471916DOI Listing
July 2017
41 Reads

HPV-negative Gastric Type Adenocarcinoma In Situ of the Cervix: A Spectrum of Rare Lesions Exhibiting Gastric and Intestinal Differentiation.

Am J Surg Pathol 2017 Aug;41(8):1023-1033

*Department of Pathology, Box Hill Hospital, Melbourne, Vic. †Department of Histopathology, King Edward Memorial Hospital, Perth, WA, Australia ‡Department of Pathology, Brigham and Women's Hospital, Boston, MA §Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). Read More

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http://Insights.ovid.com/crossref?an=00000478-201708000-0000
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http://dx.doi.org/10.1097/PAS.0000000000000855DOI Listing
August 2017
12 Reads

Expression of Glut-1 in Normal Endometrium and Endometrial Lesions: Analysis of 336 Cases.

Int J Surg Pathol 2017 Aug 18;25(5):389-396. Epub 2016 Dec 18.

1 Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Background: Glucose transporter-1 (Glut-1) is a membrane glycoprotein that is, together with other glucose transporters, responsible for the regulation of glucose uptake. An increased expression of this protein seems to be a general feature of several malignant tumors that are able to reprogram their metabolism and switch from oxidative phosphorylation to aerobic glycolysis.

Methods: We performed comprehensive immunohistochemical analysis of Glut-1 expression in 336 endometrial samples, including tumors, nontumor lesions, and normal tissues. Read More

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http://dx.doi.org/10.1177/1066896916683510DOI Listing
August 2017
8 Reads

Molecular profiles of benign and (pre)malignant endometrial lesions.

Carcinogenesis 2017 03;38(3):329-335

Department of Obstetrics and Gynaecology and.

Endometrial carcinomas are histologically classified as endometrioid, assumed to originate from hyperplastic endometrium, or non-endometrioid carcinomas, assumed to originate from atrophic endometrium. However, both on a histological and a molecular level there are indications that there are more carcinoma types and carcinogenetic pathways. This study aims to analyze endometrial carcinogenesis on a molecular level. Read More

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http://dx.doi.org/10.1093/carcin/bgx008DOI Listing
March 2017
10 Reads

The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions.

J Obstet Gynaecol 2017 Jan 22;37(1):58-63. Epub 2016 Dec 22.

a Department of Gynecology & Obstetrics , Selçuk University Faculty of Medicine , Konya , Turkey.

We evaluated the concentrations of human epididymis secretory protein E4 (HE4) and Ca-125 in relation to clinicopathologic features in patients with endometrial cancer and premalignant endometrial lesions. Women with abnormal uterine bleeding (n = 167) who underwent endometrial sampling were divided into four groups. Group 1: endometrial cancer (n = 68), group 2: atypical endometrial hyperplasia (n = 12), group 3: endometrial hyperplasia without atypia (n = 39) and group 4: controls (n = 48). Read More

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https://www.tandfonline.com/doi/full/10.3109/01443615.2016.1
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http://dx.doi.org/10.3109/01443615.2016.1174199DOI Listing
January 2017
10 Reads

New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Hum Reprod Update 2017 03;23(2):232-254

MRC Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, EdinburghEH16 4TJ, UK.

Background: Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Read More

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https://academic.oup.com/humupd/article-lookup/doi/10.1093/h
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http://dx.doi.org/10.1093/humupd/dmw042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850217PMC
March 2017
14 Reads

Stromal p16 expression is significantly increased in endometrial carcinoma.

Oncotarget 2017 Jan;8(3):4826-4836

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Read More

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http://dx.doi.org/10.18632/oncotarget.13594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354874PMC
January 2017
30 Reads

[New features in the 2014 WHO classification of uterine neoplasms].

Authors:
S F Lax

Pathologe 2016 Nov;37(6):500-511

Institut für Pathologie, LKH Graz Süd-West, Standort West, Akademisches Lehrkrankenhaus der Medizinischen Universität Graz, Göstingerstrasse 22, 8020, Graz, Österreich.

The 2014 World Health Organization (WHO) classification of uterine tumors revealed simplification of the classification by fusion of several entities and the introduction of novel entities. Among the multitude of alterations, the following are named: a simplified classification for precursor lesions of endometrial carcinoma now distinguishes between hyperplasia without atypia and atypical hyperplasia, the latter also known as endometrioid intraepithelial neoplasia (EIN). For endometrial carcinoma a differentiation is made between type 1 (endometrioid carcinoma with variants and mucinous carcinoma) and type 2 (serous and clear cell carcinoma). Read More

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http://dx.doi.org/10.1007/s00292-016-0230-4DOI Listing
November 2016
4 Reads

[Pitfalls in the histopathological diagnostics of endometrial carcinoma and its precursors : Clinically relevant differential diagnoses, avoidance of false positive diagnoses].

Authors:
F Kommoss S F Lax

Pathologe 2016 Nov;37(6):512-520

Institut für Pathologie, LKH Graz Süd-West, Graz, Österreich.

Making an incorrect histopathological diagnosis of an endometrial lesion may lead to unwanted loss of fertility and therapy-associated morbidity; therefore, endometrial carcinomas need to be correctly typed and differentiated from hyperplastic precursors, benign lesions and artifacts. Typical diagnostic pitfalls are described in this article. Misdiagnosing endometrial lesions can be avoided by paying thorough attention to gross as well as microscopic features and by taking crucial differential diagnoses into consideration. Read More

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http://dx.doi.org/10.1007/s00292-016-0236-yDOI Listing
November 2016
3 Reads

Clinicopathological and immunohistochemical characterization of papillary proliferation of the endometrium: A single institutional experience.

Oncotarget 2016 Jun;7(26):39197-39206

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Papillary proliferation of the endometrium is an unusual lesion that is composed of papillae with fibrovascular stromal cores covered with benign-appearing glandular epithelium. We studied the clinicopathological and immunohistochemical features of four cases of endometrial papillary proliferations. All patients were postmenopausal. Read More

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http://dx.doi.org/10.18632/oncotarget.10049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129925PMC
June 2016
45 Reads

Expression of ERα and PR in Various Morphological Patterns of Abnormal Uterine Bleeding-Endometrial causes in Reproductive Age Group.

J Clin Diagn Res 2016 Aug 1;10(8):EC06-9. Epub 2016 Aug 1.

HOD, Department of Pathology, Moti Lal Nehru Medical College , Allahabad, U.P., India .

Introduction: Abnormal Uterine Bleeding (AUB) is most common gynaecological problem but its management is not well defined. So FIGO/PALMCOEIN classification was developed to provide clear management options as treatment is different in PALM and AUB-E group. FIGO/PALM-COEIN classification and immunohistochemistry with ERα and PR expression in AUB-E group will be helpful in management of these patients, thus preventing surgical interventions. Read More

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http://dx.doi.org/10.7860/JCDR/2016/19565.8290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028559PMC
August 2016
26 Reads

Paired boxed gene 1 expression: A single potential biomarker for differentiating endometrial lesions associated with favorable outcomes in patients with endometrial carcinoma.

J Obstet Gynaecol Res 2016 Sep 26;42(9):1159-67. Epub 2016 May 26.

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Aim: Paired boxed gene 1 (PAX1) has previously been reported to be a methylation-silenced gene in cases of cervical and ovarian cancers. We evaluated the expression of PAX1 in normal endometrium, endometrial hyperplasia and endometrial carcinoma (EC), and investigated the prognostic value of PAX1 expression in patients with EC.

Methods: We conducted a hospital-based retrospective review of PAX1 distribution immunohistochemically in 201 samples of endometrium from biopsy or hysterectomy. Read More

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http://dx.doi.org/10.1111/jog.13040DOI Listing
September 2016
25 Reads

Comparison of saline infusion sonography (SIS) versus SIS-guided endometrial sampling in the diagnosis of endometrial pathology.

J Clin Ultrasound 2016 Sep 18;44(7):416-22. Epub 2016 Apr 18.

University of Texas Southwestern Medical Center, Department of Obstetrics and Gynecology, Dallas, TX.

Purpose: To compare saline infusion sonography (SIS) to tissue obtained from SIS-guided endometrial sampling (SISES) to determine sensitivity and specificity for benign and malignant conditions of the endometrium.

Methods: Added value of SISES after SIS was evaluated over 5 years. SIS and SISES techniques have been previously described. Read More

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http://doi.wiley.com/10.1002/jcu.22360
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http://dx.doi.org/10.1002/jcu.22360DOI Listing
September 2016
3 Reads

Thickness of preperitoneal fat as a predictor of malignancy in overweight and obese women with endometrial polyps.

Oncol Lett 2016 Mar 4;11(3):2278-2282. Epub 2016 Feb 4.

Biochemistry Section, Department of Clinical Sciences, Polytechnic University of Marche, Ancona I-60123, Italy.

The aim of the present study was to determine the association between the thickness of preperitoneal fat (PFT), utilized as an indicator of visceral fat deposition, and the risk of premalignant and malignant changes of endometrial polyps (EPs) in overweight and obese women. Overweight and obese women who had undergone diagnostic outpatient hysteroscopy and subsequent endometrial polypectomy between January 2010 and May 2013 were analyzed. Each patient underwent a transabdominal ultrasound for the purpose of measuring the thickness of preperitoneal fat. Read More

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http://dx.doi.org/10.3892/ol.2016.4186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774618PMC
March 2016
12 Reads

Endometrial Adenocarcinoma in SurePath™ Cervical Samples: Cytological Features Revisited.

Acta Cytol 2016 3;60(1):46-52. Epub 2016 Mar 3.

Department of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective: The cytomorphological criteria of malignant endometrial lesions in cervical samples are less well described than those of cervical lesions. We wished to investigate if there were features in SurePath™ liquid-based cytology samples that would facilitate more accurate differentiation between benign and malignant endometrial cells.

Study Design: This was a two-phase study, with a review of all SurePath™ samples reported as endometrial adenocarcinoma (n = 42) evaluating 12 cytological features in the first phase. Read More

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http://dx.doi.org/10.1159/000444043DOI Listing
September 2016
6 Reads

The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications.

Arch Gynecol Obstet 2016 Apr 19;293(4):695-700. Epub 2016 Feb 19.

Klinik für Gynäkologie und Geburtsmedizin, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Introduction: Molecular pathological research has contributed to improving the knowledge of different subtypes of ovarian cancer. In parallel with the implementation of the new FIGO staging classification, the WHO classification was revised. The latter is mainly based on the histopathological findings and defines the actual type of tumor. Read More

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http://link.springer.com/10.1007/s00404-016-4035-8
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http://dx.doi.org/10.1007/s00404-016-4035-8DOI Listing
April 2016
175 Reads

Can Nup88 expression be associated with atypical endometrial hyperplasia and endometrial cancer? A preliminary study.

Pathol Res Pract 2016 Apr 11;212(4):274-8. Epub 2016 Jan 11.

Department of Oncology, Institute of Clinical and Experimental Medicine, Country Council of Östergötland, University of Linköping, Linköping, Sweden. Electronic address:

Background: Nup88 is overexpressed in a number of types of carcinomas and is associated with myometrial invasion, but its exact expression pattern in endometrial cancer and premalignant lesions is unknown.

Aims: To evaluate the role of Nup88 in endometrial cancers and atypical endometrial hyperplasia and its clinicopathological significance.

Methods: Nup88 expression was examined by immunohistochemistry in samples from 104 endometrial cancers, 21 atypical endometrial hyperplasia lesions, and 40 normal endometria. Read More

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http://www.sciencedirect.com/science/article/pii/S0344033816
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http://linkinghub.elsevier.com/retrieve/pii/S034403381630003
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http://dx.doi.org/10.1016/j.prp.2016.01.003DOI Listing
April 2016
20 Reads

Loss of Mismatch Repair Protein Expression in Unselected Endometrial Adenocarcinoma Precursor Lesions.

Int J Gynecol Cancer 2016 Feb;26(2):228-32

*Department of Pathology, †Office of Biostatistics and Quantitative Health Sciences, and ‡Department of Obstetrics, Gynecology, and Women's Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.

Objective: The benefit of evaluating the precursor of endometrial carcinoma, endometrial hyperplasia (intraepithelial neoplasia [EIN]), for loss of mismatch repair (MMR) protein expression and Lynch syndrome has yet to be determined. The present study aims to establish the incidence and type of loss of MMR protein expression in unselected premalignant lesions of endometrial adenocarcinoma, as well as the agreement of immunohistochemical staining in pretreatment endometrial biopsy (EMB) specimens with subsequent uterine resections.

Methods: A retrospective review identified 112 endometrial biopsies meeting criteria for endometrial EIN. Read More

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http://dx.doi.org/10.1097/IGC.0000000000000606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648587PMC
February 2016
5 Reads

HPV-Associated Atypical Mitotic Figures in Squamous Intraepithelial Lesions of the Lower Female Genital Tract.

J Low Genit Tract Dis 2016 Apr;20(2):165-8

1Anatomical Pathology, Pathology North, Hunter New England, New Lambton and Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia; and 2Department of Pathology, Norvic International Hospital, Kathmandu, Nepal.

Objectives: Atypical mitoses with rod and dot-shaped extra pieces of chromosomes separate to the main spindle are commonly seen in HPV-associated intraepithelial lesions. To determine the reproducibility and correlation of HPV-associated atypical mitoses (HAM) with histological diagnosis and p16 status, we performed a retrospective study.

Methods: A total of 100 consecutive cervical biopsies, 10 vulvar HSIL (usual VIN), 10 differentiated VIN, 10 vulvar condylomata, 5 normal proliferative endometrial, and 5 normal ovarian follicles were assessed. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/LGT.0000000000000172DOI Listing
April 2016
5 Reads

The relationship between uterine prolapse and premalignant endometrial pathology.

Clin Exp Obstet Gynecol 2016 ;43(4):500-503

Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ- sparing surgery in patients presenting with uterine prolapse and no other complaints.

Materials And Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The posthysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or pathologic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Read More

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June 2018
3 Reads

Transvaginal ultrasound examination of the endometrium in postmenopausal women without vaginal bleeding.

Ultrasound Obstet Gynecol 2016 Sep 8;48(3):390-6. Epub 2016 Aug 8.

Department of Obstetrics and Gynecology, Skåne University Hospital Malmö, Lund University, Malmö, Sweden.

Objectives: To estimate in gynecologically asymptomatic postmenopausal women with and without hormone replacement therapy (HRT) undergoing transvaginal ultrasound examination the prevalence of: endometrial thickness ≥ 5.0 mm, intrauterine focal lesions if endometrial thickness is ≥ 5.0 mm, and premalignant and malignant endometrial changes if thickness is ≥ 5. Read More

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http://doi.wiley.com/10.1002/uog.15841
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http://dx.doi.org/10.1002/uog.15841DOI Listing
September 2016
5 Reads

Malignant degeneration of rectal endometriosis.

Rev Esp Enferm Dig 2015 Dec;107(12):761-3

Cirugía General y Digestiva, Hospital Universitario Morales Meseguer. Murcia, ESPAÑA.

Background: Endometriosis is a relatively common disease among women with child-bearing potential, and rare before puberty or following menopause. It consists of the presence of hormone-responsive endometrium outside the endometrial cavity.

Case Report: We report the case of a patient with a rectal lesion, initially approached as a primary rectal malignancy, where histopathology eventually revealed an adenocarcinoma arising from endometrial tissue in the colonic wall. Read More

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December 2015
8 Reads

Cervical deciduosis imitating dysplasia.

BMJ Case Rep 2015 Sep 22;2015. Epub 2015 Sep 22.

Department of Pathology, Haga Teaching Hospital, The Hague, The Netherlands.

Ectopic cervical deciduosis is generally an accidental finding during pregnancy, and usually presents without any symptoms or need for therapeutic intervention. However, it can sometimes imitate dysplasia or carcinoma. We report a case of a 34-year-old G2P0, with a history of cervical dysplasia, presenting at 11 weeks of gestation, with vaginal blood loss. Read More

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http://dx.doi.org/10.1136/bcr-2015-210030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593279PMC
September 2015
3 Reads

Micronucleus testing as a cancer detector: endometrial hyperplasia to carcinoma.

Arch Gynecol Obstet 2016 May 5;293(5):1065-71. Epub 2015 Sep 5.

Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Purpose: Endometrium carcinoma (EC) is the fourth common cancer among women worldwide and the incidence is increasing. It is important to define the EC earlier for survival of the patients.

Methods: Women who had endometrial hyperplasia (EH) and EC in postmenopausal and premenopausal period were included to participate in this study. Read More

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http://dx.doi.org/10.1007/s00404-015-3867-yDOI Listing
May 2016
8 Reads

Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats.

J Appl Toxicol 2016 Jun 14;36(6):769-76. Epub 2015 Jul 14.

Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.

Sulpiride and ethylene glycol monomethyl ether (EGME) are known ovarian toxicants that stimulate prolactin (PRL) secretion, resulting in hypertrophy of the corpora lutea and increased progesterone (P4) production. The purpose of the present study was to investigate how the PRL stimulatory agents affected uterine carcinogenesis and to clarify the effects of PRL on endometrial adenocarcinoma progression in rats. Ten-week-old female Donryu rats were treated once with N-ethyl-N'-nitro-N-nitrosoguanidine (20 mg kg(-1) ), followed by treatment with sulpiride (200 ppm) or EGME (1250 ppm) from 11 weeks of age to 12 months of age. Read More

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http://dx.doi.org/10.1002/jat.3206DOI Listing
June 2016
9 Reads

A diagnostic dilemma for solid ovarian masses: the clinical and radiological aspects with differential diagnosis of 23 cases.

Eur J Gynaecol Oncol 2015 ;36(2):186-91

Objective: This study aimed to analyze the clinical characteristics and diagnostic features of ovarian fibromatous masses.

Materials And Methods: The authors reviewed the records of 23 women who underwent laparotomic surgeries and whose final histopathological diagnoses were ovarian fibroma, cellular fibroma, or fibrothecoma from January 2005 to January 2013. The clinical, ultrasonographic, magnetic resonance imaging, tumor marker, therapeutic, and histologic data were analyzed. Read More

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August 2015
2 Reads

The American College of Obstetricians and Gynecologists Committee Opinion no. 631. Endometrial intraepithelial neoplasia.

Authors:

Obstet Gynecol 2015 May;125(5):1272-8

Endometrial hyperplasia is of clinical significance because it is often a precursor lesion to adenocarcinoma of the endometrium. Making the distinction between hyperplasia and true precancerous lesions or true neoplasia has significant clinical effect because their differing cancer risks must be matched with an appropriate intervention to avoid undertreatment or overtreatment. Pathologic diagnosis of premalignant lesions should use criteria and terminology that clearly distinguish between clinicopathologic entities that are managed differently. Read More

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http://dx.doi.org/10.1097/01.AOG.0000465189.50026.20DOI Listing
May 2015
4 Reads

Significance of p53 expression in background endometrium in endometrial carcinoma.

Virchows Arch 2015 Jun 19;466(6):695-702. Epub 2015 Mar 19.

Department of Obstetrics and Gynecology, School of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan,

The p53 signature (p53S) has been proposed to be a marker of the earliest phase of development of endometrial serous carcinoma. We examined the presence of p53S in the background endometrium in cases of endometrial carcinoma. From a series of 351 endometrial carcinomas, 225 (64. Read More

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http://dx.doi.org/10.1007/s00428-015-1752-5DOI Listing
June 2015
28 Reads

Does uterine prolapse alter endometrial cyclooxygenase 2 expression and promote the development of premalignant lesions?

Gynecol Obstet Invest 2015 5;80(2):119-23. Epub 2015 Feb 5.

Department of Obstetrics and Gynecology, Sifa University School of Medicine, Izmir, Turkey.

Objective: The aim of this study was to evaluate the expression of cyclooxygenase 2 (COX-2) and its association with the development of premalignant lesions in gland structures of the endometrium in patients with uterine prolapse, a condition which exposes the uterus to mechanical and infectious stress.

Methods: The study included 102 patients who underwent hysterectomy to correct grade 3-4 uterine prolapse and 105 patients who underwent hysterectomy for other causes. Endometrial gland structures underwent immunohistochemical staining and COX-2 expression was graded. Read More

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http://dx.doi.org/10.1159/000371348DOI Listing
June 2016
7 Reads

Antiproliferative effect of metformin on the endometrium--a clinical trial.

Asian Pac J Cancer Prev 2014 ;15(23):10067-70

Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences, Tabriz, Iran E-mail ???

Background: Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone.

Materials And Methods: A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosis were disordered proliferative endometrium or simple endometrial hyperplasia were included and randomly distributed in two groups treated with metformin (500mg Bid) or megestrol (40mg daily), respectively, for three months. Read More

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September 2015
11 Reads

Characterization of precursor lesions in the endometrium and fallopian tube epithelium of early-stage uterine serous carcinoma.

Int J Gynecol Pathol 2015 Jan;34(1):57-64

Department of Obstetrics and Gynecology (M.C.T., W.A.C., S.C.D.), Division of Gynecologic Surgery Department of Laboratory Medicine and Pathology (F.M., J.F.L., J.L.H., J.L.D.), Mayo Clinic, Rochester, Minnesota Departments of Obstetrics and Gynecology (E.M.S.) Pathology (R.L.G.), Division of Gynecologic Oncology, University of Washington, Seattle, Washington.

To determine if selected cases of uterine serous carcinoma (USC) arise from tubal rather than endometrial epithelium. Bilateral fallopian tubes from 38 women with pure USC were entirely submitted for histopathologic examination using the protocol Sectioning and Extensively Examining the FIMbria (SEE-FIM). Non-neoplastic endometrium was extensively sampled. Read More

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http://pdfs.journals.lww.com/intjgynpathology/2015/01000/Cha
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http://dx.doi.org/10.1097/PGP.0000000000000109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405903PMC
January 2015
14 Reads

Pax2 expression in simultaneously diagnosed WHO and EIN classification systems.

Int J Gynecol Pathol 2015 Jan;34(1):40-6

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

PAX2 has been cited as a technically robust biomarker which nicely delineates precancerous lesions of the endometrium when the endometrial intraepithelial neoplasia (EIN) classification scheme is used. Its utility in distinguishing between atypical and nonatypical hyperplasia when applied within the 1994 World Health Organization classification system is questionable. The purpose of this study was to evaluate PAX2 in a side by side comparison of its staining patterns in a series of endometrial samples that were classified using both systems. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000185DOI Listing
January 2015
8 Reads

Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.

Iran J Cancer Prev 2013 ;6(4):209-13

Dept. of Pathology, Tehran University of Medical Sciences, Tehran, Iran.

Background: Endometrial cancer is the most common gynecologic malignancy that has often proceeded by a premalignant phase. Modern molecular and immunostaining methods for precancerous lesions diagnosis have been expanded. One of the genetic alternations in the endometrial cancer carcinogenesis is the mutational activation of the K-ras oncogene. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142936PMC
September 2014
5 Reads

Combined colonoscopy and endometrial biopsy cancer screening results in women with Lynch syndrome.

Gynecol Oncol 2014 Oct 19;135(1):85-9. Epub 2014 Aug 19.

Department of Gastroenterology, Hepatology, and Nutrition, The University Of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Objective: Endometrial biopsy (EMBx) and colonoscopy performed under the same sedation is termed combined screening and has been shown to be feasible and to provide a less painful and more satisfactory experience for women with Lynch syndrome (LS). However, clinical results of these screening efforts have not been reported. The purpose of this study was to evaluate the long-term clinical outcomes and patient compliance with serial screenings over the last 10. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258140127
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http://dx.doi.org/10.1016/j.ygyno.2014.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389779PMC
October 2014
12 Reads

Treatment of simple and complex endometrial non-atypical hyperplasia with natural progesterone: response rate to different doses.

Gynecol Endocrinol 2014 11;30(12):899-901. Epub 2014 Aug 11.

a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.

The aim of this study is to evaluate the response rate to natural progesterone in non-atypical endometrial hyperplasia and to identify the lowest effective dose. A total of 197 patients of childbearing age with simple or complex hyperplasia were retrospectively identified. The women were treated with a cyclic administration of progesterone at different dosages (100 versus 200 versus 300 mg daily). Read More

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http://dx.doi.org/10.3109/09513590.2014.945904DOI Listing
October 2016
3 Reads

Accuracy of hysteroscopy made by young residents in detecting endometrial pathologies in postmenopausal women.

Eur J Gynaecol Oncol 2014 ;35(3):219-23

Purpose Of Investigation: The aim of the study was to analyze the diagnostic value of hysteroscopy made by young residents in evaluating uterine cavity compared to experienced hysteroscopists with histological diagnosis as reference in postmenopausal women, with particular attention to endometrial hyperplasia and cancer.

Materials And Methods: A total of 600 postmenopausal women that underwent diagnostic hysteroscopy (DH) between January 2011 and December 2013 were evaluated. The authors compared the first 200 hysteroscopic findings of each young resident with those of seniors that supervised all the procedures, regarding the same patients. Read More

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July 2014
8 Reads

Fertility preserving treatment in a nulliparous with a molar pregnancy: a case report.

Rom J Morphol Embryol 2014 ;55(2):449-52

"Carol Davila" University of Medicine and Pharmacy, Elias Emergency Hospital, Bucharest, Romania;

Hydatidiform mole represents an abnormal form of conception that occurs in about one in 500-1000 pregnancies. It is a subtype of gestational trophoblastic disease. Hydatidiform moles should be regarded as premalignant lesions because 15-20% of complete hydatidiform moles (CHMs) and 1% of partial hydatidiform moles (PHMs) undergo malignant transformation into invasive moles, choriocarcinomas, or, in rare cases, placental-site trophoblastic tumors (PSTTs). Read More

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April 2015
4 Reads

Premalignant and malignant lesions in endometrial polyps in patients undergoing hysteroscopic polypectomy.

Einstein (Sao Paulo) 2014 Jan-Mar;12(1):16-21

Hospital do Servidor Público Estadual ?Francisco Morato de Oliveira?, São Paulo, SP, Brazil.

Objective: To evaluate the incidence of premalignant lesions and cancer in endometrial polyps, in patients undergoing hysteroscopic polypectomy.

Methods: The results of 1,020 pathological examinations of patients submitted to hysteroscopic polypectomy were analyzed, as well as their diagnostic and surgical hysteroscopy findings. As to their menstrual status, 295 (28. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898233PMC
November 2014
12 Reads

Are neutrophil/lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding?

Asian Pac J Cancer Prev 2014 ;15(4):1689-92

Department of Obstetrics and Gynecology, Kayseri Education and Research Hospital, Kayseri, Turkey E-mail :

Background: An easy, reproducible and simple marker is needed to estimate phase of endometrial pathologic lesions such as hyperplasia and endometrial cancer and distinguish from pathologically normal results. We here aimed to clarify associations among neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), endometrial hyperplasia and cancer in patients with abnormal uterine bleeding.

Materials And Methods: Patients (n=161) who were admitted with abnormal uterine bleeding and the presence of endometrial cells on cervical cytology or thick endometrium were investigated. Read More

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November 2014
9 Reads

Evaluation of endometrial precancerous lesions in postmenopausal obese women--a high risk group?

Asian Pac J Cancer Prev 2014 ;15(1):195-8

Department of Obstetrics and Gynecology, Kayseri Education and Research Hospital of Medicine, Kayseri, Turkey E-mail :

Aim: To evaluate precancerous lesions such as hyperplasia and endometrial polyps in obese postmenopausal women.

Materials And Methods: Women who were referred with abnormal uterine bleeding in postmenopausal period or the presence of endometrial cells on cervical cytology in our department were investigated. Anthropometric measurements such as height, weight, body mass index, waist/hip ratio and endometrial thickness were compared between a precancerous lesion (hyperplasia and endometrial polyp) group and a pathologically normal group. Read More

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November 2014
6 Reads