271 results match your criteria Premalignant Lesions of the Endometrium


Wiad Lek 2021 ;74(3 cz 1):388-394


Objective: The aim: To conduct a morphological study of endometrial tissue to identify changes characteristic of viral lesions to develop improved antirelapse treatment of HPE in women of reproductive age.

Patients And Methods: Materials and methods: We surveyed 90 patients of the gynecological department who sought medical for hyperplastic processes of the endometrium in reproductive age. All women underwent hysteroscopy, the resulting material was subjected to morphological examination. Read More

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Proteomic Analysis of Pre-Invasive Serous Lesions of the Endometrium and Fallopian Tube Reveals Their Metastatic Potential.

Front Oncol 2020 15;10:523989. Epub 2020 Dec 15.

Future Industries Institute, Mawson Lakes Campus, University of South Australia, Adelaide, SA, Australia.

Serous endometrial cancer (SEC) and high grade serous ovarian cancer (HGSOC) are aggressive gynecological malignancies with high rates of metastasis and poor prognosis. Endometrial intraepithelial carcinoma (EIC), the precursor for SEC, and serous tubal intraepithelial carcinoma (STIC), believed to be the precursor lesion for HGSOC, can also be associated with intraabdominal spread. To provide insight into the etiology of these precancerous lesions and to explore the potential molecular mechanisms underlying their metastatic behavior, we performed a proteomic mass spectrometry analysis in a patient with synchronous EIC and STIC. Read More

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December 2020

TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions: A retrospective clinical study.

Medicine (Baltimore) 2020 Nov;99(48):e23397

Department of Gynecologic Oncology.

The aim of this study was to assess the correlation of TWIST1 expression with clinical parameters and the prognosis of type I endometrial cancer (EC).This retrospective study enrolled 345 patients. Immunohistochemical staining was performed on 55 normal endometrium (NE) samples, 27 atypical hyperplasia (AH) samples, and 263 type I EC samples. Read More

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November 2020

The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology.

Front Endocrinol (Lausanne) 2020 9;11:594370. Epub 2020 Oct 9.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.

Over the last years, increasing evidence has focused on crucial pathogenetic role of PRL on malignant, premalignant and benign uterine diseases. Studies in animals and humans have documented that PRL receptors (PRL-Rs) are widely expressed on uterine cells and that PRL is directly synthesized by the endometrium under the stimulatory action of progesterone. Uterine PRL secretion is finely modulated by autocrine/paracrine mechanisms which do not depend on the same control factors implied in the regulation of PRL secretion from pituitary. Read More

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October 2020

A Novel Risk-Scoring Model for Prediction of Premalignant and Malignant Lesions of Uterine Endometrium Among Symptomatic Premenopausal Women.

Int J Womens Health 2020 27;12:883-891. Epub 2020 Oct 27.

Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Purpose: Uterine cancer is the second most prevalent cancer of the female genital tract, with 90% of it being of endometrial origin. The aim of this research was to create and validate a risk-scoring model using patients' clinical variables in predicting premalignant and malignant lesions of the uterine endometrium among premenopausal women with abnormal uterine bleeding (AUB).

Methods: This is a retrospective cohort study conducted at a tertiary hospital of Southern India for a period of 5 years from July 2014 to August 2019, including women aged ≤55 years who had AUB and underwent endometrial biopsy. Read More

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October 2020

Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.

Am J Surg Pathol 2020 10;44(10):1429-1439

Departments of Pathology.

Background: Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions is often problematic because of the profound morphologic changes induced by progestin and the lack of established diagnostic criteria for progestin-treated residual AH.

Methods: We conducted a longitudinal study of 265 endometrial biopsies from 54 patients with a history of AH on progestin therapy. Read More

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October 2020

Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P.

BMC Cancer 2020 Sep 3;20(1):845. Epub 2020 Sep 3.

Obstetrics and Gynecology Hospital, Fudan University, Postal address: 413 Zhaozhou Road, Shanghai, 200011, China.

Background: Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. Read More

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September 2020

Atrophic endometrium in postmenopausal women referred to diagnostic hysteroscopy: a study to avoid unnecessary examinations.

Eur Rev Med Pharmacol Sci 2020 05;24(10):5217-5222

Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy.

Objective: Any diagnostic workup should be based on appropriateness criteria. Diagnostic hysteroscopy is a procedure widely used in endometrial pathology. Its high outpatient feasibility frequently leads to misuse. Read More

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Can we rely on blind endometrial curettage for complete removal of focal intrauterine lesion? A prospective clinical study.

J Gynecol Obstet Hum Reprod 2020 Apr 1;49(4):101696. Epub 2020 Feb 1.

Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.

Objective: To investigate the diagnostic and therapeutic efficiency of dilatation-curettage (D&C) combined with aspiration curettage for endometrial pathology compared to hysteroscopy alone in this study.

Material And Methods: A total of 143 patients who have suspicion of endometrial mass like lesion, increased endometrial thickness (>5-mm at menopause and/or endometrial thickness upper than 5-mm in patients under tamoxifen treatment due to breast cancer during 2-D transvaginal ultrasonography examination) were enrolled. All patients underwent procedures in order of hysteroscopy, D&C plus aspiration and second look hysteroscopy. Read More

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The Value of DNA Quantitative Cytology Test for the Screening of Endometrial Cancer.

Cancer Manag Res 2019 11;11:10383-10391. Epub 2019 Dec 11.

Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, People's Republic of China.

Objective: To evaluate the accuracy, sensitivity, and specificity of DNA quantitative cytology test for the diagnosis of endometrial cancer or precancerous lesions and then discuss the value of DNA quantitative cytology as a screening tool for endometrial cancer.

Methods: The study enrolled 575 patients from September 2013 to January 2017 in Shanghai Minhang Central Hospital. Endometrial hysteroscopy plus dilation and curettage and DNA quantitative cytology tests were conducted as a method for the diagnosis of endometrial cancer. Read More

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December 2019

Endometriosis-related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions.

Histopathology 2020 Jan;76(1):76-92

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Endometriosis is an extremely common condition and, in most cases, establishing a histological diagnosis is straightforward, although a variety of benign alterations may result in problems with interpretation. In this review, I discuss selected uncommon variants of endometriosis or benign alterations that may result in diagnostic problems. The topics covered include the contentious issue of so-called atypical endometriosis, stromal endometriosis, polypoid endometriosis, and the association of endometriosis with florid mesothelial hyperplasia. Read More

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January 2020

Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.

Int J Environ Res Public Health 2019 11 20;16(23). Epub 2019 Nov 20.

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Background: Pyruvate kinase M2 (PKM2) is a regulator of the processes of glycolysis and oxidative phosphorylation, but the roles that it plays in endometrial cancer remain largely unknown. This study evaluated the PKM2 expression in normal endometrium, endometrial hyperplasia, and endometrial carcinoma, and its prognostic value was investigated in endometrial carcinoma patients.

Methods: A hospital-based retrospective review was conducted to examine the immunohistochemical PKM2 distribution in 206 endometrium samples from biopsies or hysterectomies. Read More

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November 2019

Ultrasonic and Histopathological Evaluation to Exclude Premalignant and Malignant Lesions in Perimenopausal and Postmenopausal Women Presenting as Abnormal Uterine Bleeding.

J Obstet Gynaecol India 2019 Oct 21;69(Suppl 2):171-176. Epub 2018 Aug 21.

4Biostatics, IGIMS, Patna, India.

Introduction: Abnormal uterine bleeding may be defined as bleeding pattern that differs in frequency, duration and amount from a pattern observed during a normal menstrual cycle or after menopause.

Aim And Objective: The aim of this study was (1) to identify the different benign, premalignant and malignant conditions as the cause of abnormal uterine bleeding in perimenopausal and postmenopausal women and (2) to find out the different histopathological patterns of endometrium and cervix in these women.

Materials And Methods: This is a prospective study done in gynaecological oncology in 100 cases attending the OPD. Read More

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October 2019

Abnormal Uterine Bleeding.

Obstet Gynecol Clin North Am 2019 Dec 25;46(4):595-605. Epub 2019 Sep 25.

New York University School of Medicine, 530 First Avenue, Suite 10N, New York, NY 10016, USA. Electronic address:

Abnormal uterine bleeding (AUB) is a common medical problem, with a direct influence on women's quality of life, utilization of health care resources, and costs. AUB in women older than 40 years and especially in postmenopausal women requires a prompt and efficient evaluation, mainly to exclude the presence of malignant or premalignant lesions of the endometrium. Cancer of the endometrium is the most common gynecologic malignancy, with an incidence in the United States of more than 60,000 cases and mortality estimated at 10,000 women annually. Read More

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December 2019

Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression.

Int J Gynecol Pathol 2020 Mar;39(2):163-169

Epithelial proliferations in the fallopian tube have been characterized by some as stem cell outgrowths (SCOUTs) and divided into type I and type II. Type II SCOUTs exhibit diffuse cellular beta-catenin nuclear staining (β-catenin), implying a CTNNB1 mutation. SCOUTs are more common in perimenopausal and postmenopausal women and are associated with ovarian cancer but have not been linked directly to malignancy. Read More

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Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases.

J Minim Invasive Gynecol 2020 Jul - Aug;27(5):1087-1094. Epub 2019 Aug 12.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku (Drs. Matoba, Banno, Kisu, Kobayashi, Tsuji, Nagai, Yamagami, Nakamura, Tominaga, and Aoki).

Study Objective: To examine the diagnostic accuracy of hysteroscopic photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5ALA) in patients with endometrial cancer and premalignant atypical endometrial hyperplasia.

Design: A single-center, open-label, exploratory intervention study.

Setting: University Hospital in Japan. Read More

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December 2020

Benign and Premalignant Lesions of the Endometrium.

Surg Pathol Clin 2019 Jun 3;12(2):315-328. Epub 2019 Apr 3.

Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 517, Little Rock, AR 72205, USA. Electronic address:

In this review, we highlight the benign and premalignant lesions of the endometrium that the pathologist may encounter in daily practice. We begin by detailing our current understanding of excess estrogen in the progression of endometrial neoplasia. We outline the currently accepted terminology to be used when evaluating proliferative endometrial lesions, while highlighting their key features. Read More

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Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Proc Natl Acad Sci U S A 2019 03 19;116(10):4528-4537. Epub 2019 Feb 19.

Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210;

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. Read More

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Effects of Jaeumkanghwa-tang on tamoxifen responsiveness in preclinical ER+ breast cancer model.

Endocr Relat Cancer 2019 03;26(3):339-353

Department of Oncology, Georgetown University, Washington, District of Columbia, USA.

Resistance to endocrine therapy remains a clinical challenge in the treatment of estrogen receptor-positive (ER+) breast cancer. We investigated if adding a traditional Asian herbal mixture consisting of 12 herbs, called Jaeumkanghwa-tang (JEKHT), to tamoxifen (TAM) therapy might prevent resistance and recurrence in the ER+ breast cancer model of 7,12-dimethylbenz[a]anthracene (DMBA)-exposed Sprague-Dawley rats. Rats were divided into four groups treated as follows: 15 mg/kg TAM administered via diet as TAM citrate (TAM only); 500 mg/kg JEKHT administered via drinking water (JEKHT only group); TAM + JEKHT and no treatment control group. Read More

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Gene Promoter Methylation in Endometrial Carcinogenesis.

Pathol Oncol Res 2019 Apr 14;25(2):659-667. Epub 2018 Nov 14.

Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Up to 60% of untreated atypical hyperplastic endometrium will develop into endometrial carcinoma (EC), and for those who underwent a hysterectomy a coexisting EC is found in up to 50%. Gene promoter methylation might be related to the EC development. The aim of this study is to determine changes in gene promoter profiles in normal endometrium, atypical hyperplasia (AH) and EC in relation to K-Ras mutations. Read More

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Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy.

Cold Spring Harb Mol Case Stud 2018 12 17;4(6). Epub 2018 Dec 17.

Department of Obstetrics/Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Endometrial cancer is the most common gynecologic malignancy in industrialized countries, and both its incidence and its associated mortality are increasing. The "liquid biopsy" is becoming an important transformative precision oncology tool, but barriers intrinsic to blood sampling have limited its use in early cancer detection. We hypothesized that using a more targeted sample for analysis-namely, a uterine lavage-should provide a more sensitive and specific diagnostic test for endometrial cancer. Read More

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December 2018

Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma

Asian Pac J Cancer Prev 2018 Aug 24;19(8):2291-2297. Epub 2018 Aug 24.

Department of Pathology, Faculty of Medicine, Zagazig University, Cairo, Egypt. Email:

Background: Endometrial carcinomas are common gynecologic malignancies worldwide. In Egypt they represent 2.6 %. Read More

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Expression of Laminin Receptor 1 in Normal, Hyperplastic, and Malignant Endometrium.

Int J Gynecol Pathol 2019 Jul;38(4):326-334

Department of Obstetrics and Gynecology, Kudret International Hospital (M.K.) Department of Obstetrics and Gynecology, Ankara Education and Research Hospital (Z. Kurdoglu), Ankara Department of Obstetrics and Gynecology, Medicana Konya (Z. Kucukaydin) Department of Pathology, Konya Training and Research Hospital (Y.U.), Konya Department of Pathology, Yuzuncu Yil University School of Medicine, Van (G.B., S.O.), Turkey.

Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed. Read More

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Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice.

Toxicol Pathol 2018 07 12;46(5):574-596. Epub 2018 Jun 12.

2 Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

Developmental exposure to estrogenic chemicals is an established risk factor for cancer of the female reproductive tract. This increase in risk has been associated with disruption of normal patterns of cellular differentiation during critical stages of morphogenesis. The goal of this study was to document uterine epithelial phenotypes over time following neonatal treatment with the synthetic estrogen diethylstilbestrol (DES) or the soy phytoestrogen genistein (GEN) in female CD-1 mice. Read More

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Clinicopathological Characteristics and Mutation Status of Endometrial Mucinous Metaplasia and Carcinoma.

Anticancer Res 2018 05;38(5):2779-2786

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Background/aim: Mucinous metaplasia of the endometrium occurs as a spectrum of epithelial alterations ranging from the formation of simple, tubular glands to architecturally complex glandular proliferation with intraglandular papillary projection and cellular tufts. Endometrial mucinous metaplasia often presents a diagnostic challenge in endometrial curettage.

Materials And Methods: We analyzed the clinicopathological characteristics and the mutation status for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial mucinous metaplasia. Read More

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Routine histologic features in complex atypical hyperplasia can predict the presence of endometrial carcinoma: a clinicopathological study of 222 cases.

Hum Pathol 2018 10 17;80:40-46. Epub 2018 Mar 17.

Department of Pathology, Women & Infants Hospital of Rhode Island, Providence, RI 02905, USA; Department of Pathology, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.

There is a wide range of finding endometrial adenocarcinoma (ADCA) in the uterus after a diagnosis of complex atypical hyperplasia (CAH), likely due to a poor diagnostic reproducibility and an inherent heterogeneity in CAH. We evaluated whether histologic subtyping of CAH would help predict ADCA. Our study consisted of 222 cases of CAH diagnosed by endometrial biopsy or curettage. Read More

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October 2018

Factors Associated with Malignancy in Hysteroscopically Resected Endometrial Polyps: A Systematic Review and Meta-Analysis.

J Minim Invasive Gynecol 2018 Jul - Aug;25(5):777-785. Epub 2018 Feb 14.

From the Department of Medical Sciences, University of Brasilia, Brasilia, Brazil.

In this study, we aimed to estimate the frequency of premalignant and malignant lesions in endometrial polyps, and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of premalignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible. Read More

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Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens.

Virchows Arch 2018 Jun 14;472(6):907-917. Epub 2018 Feb 14.

Department of Pathology, The University of Hong Kong, Block T, Queen Mary Hospital, 102 Pok Fu Lam Road, Pok Fu Lam, Hong Kong SAR.

Benign proliferations that mimic malignancies are commonly encountered during the course of assessment of small and fragmented endometrial samples. Although benign, endometrial epithelial metaplasias often coexist with premalignant or malignant lesions causing diagnostic confusion. The difficulty with mucinous metaplasia lies in its distinction from atypical mucinous glandular proliferations and mucinous carcinomas, which are associated with significant interobserver variability. Read More

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The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions.

Med Hypotheses 2018 Jan 13;110:80-82. Epub 2017 Nov 13.

Gynecology Department, IRCCS Ospedale San Raffaele, Via Olgettina, 60, Milan, Italy. Electronic address:

Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Read More

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January 2018