288 results match your criteria Premalignant Lesions of the Endometrium

Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study.

Int J Mol Sci 2022 Jun 2;23(11). Epub 2022 Jun 2.

Centre for Women's Health Research, Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L8 7SS, UK.

Endometrial cancer (EC) is the most common gynaecological malignancy. Nucleolin () is involved in rDNA transcription, cell proliferation, and apoptosis, with high expression associated with worse overall survival (OS) in other adenocarcinomas. Our aims were to assess gene and protein expression and explore the differential expression of -associated genes (NAGs) in endometrial carcinogenesis. Read More

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Diagnosis of endometrium hyperplasia and screening of endometrial intraepithelial neoplasia in histopathological images using a global-to-local multi-scale convolutional neural network.

Comput Methods Programs Biomed 2022 Jun 24;221:106906. Epub 2022 May 24.

Xi'an Key Lab of Radiomics and Intelligent Perception, School of Information Science and Technology, Northwest University, Xi'an, Shaanxi 710069, China. Electronic address:

Background And Objective: Endometrial hyperplasia (EH), a uterine pathology characterized by an increased gland-to-stroma ratio compared to normal endometrium (NE), may precede the development of endometrial cancer (EC). Particularly, atypical EH also known as endometrial intraepithelial neoplasia (EIN), has been proven to be a precursor of EC. Thus, diagnosing different EH (EIN, hyperplasia without atypia (HwA) and NE) and screening EIN from non-EIN are crucial for the health of female reproductive system. Read More

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YTHDF2 is a novel diagnostic marker of endometrial adenocarcinoma and endometrial atypical hyperplasia/ intraepithelial neoplasia.

Pathol Res Pract 2022 Jun 28;234:153919. Epub 2022 Apr 28.

Department of Pathology, The Third Affiliated Hospital, Guangzhou Medical University, 510150 Guangzhou, China; Guangdong Provincial key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

Numerous studies show that some biomarkers are aberrantly expressed in endometrial endometrioid adenocarcinoma (EMAC) and endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia (EAH/EIN) compared to endometrial benign lesions. Because of low sensitivity and/or specificity, the utility of these markers to distinguish EMAC and EAH/EIN from benign endometrial lesions is limited. YTH domain family 2 (YTHDF2) is a functional N-methyladenosine (mA)-specific reader protein that mainly regulates mRNA stability. Read More

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Clinical significance of endometrial abnormalities: an observational study on 1020 women undergoing hysteroscopic surgery.

BMC Womens Health 2022 04 7;22(1):106. Epub 2022 Apr 7.

Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Rome, Italy.

Background: The overall clinical significance of the finding of endometrial abnormalities in predicting premalignant/malignant endometrial lesions is still incompletely determined. For this reason the management, surgical or expectant, of women in which an endometrial abnormality has been detected is debated.

Methods: This retrospective study was carried out on 1020 consecutive women, 403 premenopausal and 617 postmenopausal, who underwent operative hysteroscopy in a University Hospital for suspected endometrial abnormalities, which were detected by transvaginal ultrasound (TVS) and/or office hysteroscopy. Read More

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Abnormal Uterine Bleeding among Women Visiting Gynecology Out- patient Department of a Tertiary Care Hospital: A Descriptive Cross- sectional Study.

JNMA J Nepal Med Assoc 2022 Feb 15;60(246):121-125. Epub 2022 Feb 15.

Department of Radiodiagnosis and Imaging, Lumbini Medical College and Teaching Hospital, Palpa, Nepal.

Introduction: Abnormal uterine bleeding accounts for more than 70% of complaints in peri- and post-menopausal women. The main purpose of investigating them is to rule out premalignant and malignant endometrial lesions. This study aimed to find out the prevalence of abnormal uterine bleeding among out-patients visiting the gynecology department of a tertiary care hospital. Read More

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February 2022

Is Computer-Assisted Tissue Image Analysis the Future in Minimally Invasive Surgery? A Review on the Current Status of Its Applications.

J Clin Med 2021 Dec 9;10(24). Epub 2021 Dec 9.

Biomedical Engineering Research Center, Department of Computer Science, University of Cyprus, 1678 Nicosia, Cyprus.

Purpose: Computer-assisted tissue image analysis (CATIA) enables an optical biopsy of human tissue during minimally invasive surgery and endoscopy. Thus far, it has been implemented in gastrointestinal, endometrial, and dermatologic examinations that use computational analysis and image texture feature systems. We review and evaluate the impact of in vivo optical biopsies performed by tissue image analysis on the surgeon's diagnostic ability and sampling precision and investigate how operation complications could be minimized. Read More

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December 2021

Loss of ten-eleven translocation 1 (TET1) expression as a diagnostic and prognostic biomarker of endometrial carcinoma.

PLoS One 2021 3;16(11):e0259330. Epub 2021 Nov 3.

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Endometrial carcinoma (EC) is the most common gynecological cancer. However, there is currently no routinely used biomarker for differential diagnosis of malignant and premalignant endometrial lesions. Ten-eleven translocation (TET) proteins, especially TET1, were found to play a significant role in DNA demethylation, via conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). Read More

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December 2021

Change of Practice Patterns Following an Educational Comment on Reports of Benign-Appearing Endometrial Cells in Papanicolaou Tests.

Am J Clin Pathol 2022 Mar;157(3):413-416

Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objectives: Since the publication of our study demonstrating high negative predictive values (>99% for women in their 40s) of benign-appearing endometrial cells (nEMCs), we have begun to include an educational comment in Papanicolaou (Pap) test reports with nEMCs that recommends routine periodic screening for asymptomatic premenopausal women (APW). The current study evaluated how the inclusion of this comment has affected clinical practice patterns at our institution.

Methods: The 2017 to 2019 database identified 175 reports containing the educational comment in women aged 45 to 54 years with a follow-up time of 11 to 37 months. Read More

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The clinical importance of polyp size measurement through two-dimensional saline infusion sonohysterography prior to hysteroscopic resection in predicting premalignant and malignant endometrial lesions.

Int J Gynaecol Obstet 2022 Jun 24;157(3):582-587. Epub 2021 Sep 24.

Department of Obstetrics and Gynecology, Medicana Ataşehir Hospital, Istanbul, Turkey.

Objective: To evaluate the clinical importance of endometrial polyp size measured using saline infusion sonohysterography (SIS) before performing a hysteroscopic resection in predicting premalignant/malignant lesions.

Methods: A retrospective observational study analysis was conducted of 365 patients, who underwent SIS, in a reference hospital. The longest plane of the polyp size was taken as base. Read More

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Comparison of endometrial cancer risk in patients with endometrial precancerous lesions: WHO 1994 vs EIN classification.

J Obstet Gynaecol 2022 May 20;42(4):692-695. Epub 2021 Aug 20.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Hacettepe University, Ankara, Turkey.

Our aim was to investigate the frequency of concurrent endometrial cancer in patients with endometrial precancerous lesions (PCLs) using World Health Organization 1994 (WHO94) and endometrial intraepithelial neoplasia (EIN) systems. We retrospectively investigated patients that underwent surgery for endometrial PCLs according to WHO94 or EIN systems at Hacettepe University Gynecology Clinic between January 2002 and June 2014. Of the 267 patients, 189 (70. Read More

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ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas.

Sci Rep 2021 06 7;11(1):11949. Epub 2021 Jun 7.

4525 MacDonald Research Laboratories, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.

In type 1 endometrial cancer, unopposed estrogen stimulation is thought to lead to endometrial hyperplasia which precedes malignant progression. Recent data from our group and others suggest that ALDH activity mediates stemness in endometrial cancer, but while aldehyde dehydrogenase 1 (ALDH1) has been suggested as a putative cancer stem cell marker in several cancer types, its clinical and prognostic value in endometrial cancer remains debated. The aim of this study was to investigate the clinical value of ALDH1 expression in endometrial hyperplasia and to determine its ability to predict progression to endometrial cancer. Read More

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Wiad Lek 2021 ;74(3 cz 1):388-394


Objective: The aim: To conduct a morphological study of endometrial tissue to identify changes characteristic of viral lesions to develop improved antirelapse treatment of HPE in women of reproductive age.

Patients And Methods: Materials and methods: We surveyed 90 patients of the gynecological department who sought medical for hyperplastic processes of the endometrium in reproductive age. All women underwent hysteroscopy, the resulting material was subjected to morphological examination. Read More

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Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.

J Pathol 2021 05 9;254(1):20-30. Epub 2021 Mar 9.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

The endometrium is unique as an accessible anatomic location that can be repeatedly biopsied and where diagnostic biopsies do not extirpate neoplastic lesions. We exploited these features to retrospectively characterize serial genomic alterations along the precancer/cancer continuum in individual women. Cases were selected based on (1) endometrial cancer diagnosis/hysterectomy and (2) preceding serial endometrial biopsies including for some patients an early biopsy before a precancer histologic diagnosis. Read More

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Proteomic Analysis of Pre-Invasive Serous Lesions of the Endometrium and Fallopian Tube Reveals Their Metastatic Potential.

Front Oncol 2020 15;10:523989. Epub 2020 Dec 15.

Future Industries Institute, Mawson Lakes Campus, University of South Australia, Adelaide, SA, Australia.

Serous endometrial cancer (SEC) and high grade serous ovarian cancer (HGSOC) are aggressive gynecological malignancies with high rates of metastasis and poor prognosis. Endometrial intraepithelial carcinoma (EIC), the precursor for SEC, and serous tubal intraepithelial carcinoma (STIC), believed to be the precursor lesion for HGSOC, can also be associated with intraabdominal spread. To provide insight into the etiology of these precancerous lesions and to explore the potential molecular mechanisms underlying their metastatic behavior, we performed a proteomic mass spectrometry analysis in a patient with synchronous EIC and STIC. Read More

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December 2020

Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.

J Pathol 2021 04 6;253(4):355-365. Epub 2021 Feb 6.

Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, Canada.

Endometrial carcinoma (EC) is classified into a wide range of morphological variants; this list has expanded over the past decade with the inclusion of mesonephric-like and dedifferentiated carcinoma as EC variants in the fifth edition of the WHO Classification of Female Genital Tumours, and recognition that carcinosarcoma is a biphasic carcinoma rather than a sarcoma. Each EC variant has distinct molecular abnormalities, including TCGA-based molecular subtypes, allowing further subclassification and adding complexity. In contrast to this rapid progress in understanding EC, there are only two recognized EC precursor lesions: endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia (EAH/EIN) and serous intraepithelial carcinoma, a situation that has not changed for many years. Read More

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TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions: A retrospective clinical study.

Medicine (Baltimore) 2020 Nov;99(48):e23397

Department of Gynecologic Oncology.

The aim of this study was to assess the correlation of TWIST1 expression with clinical parameters and the prognosis of type I endometrial cancer (EC).This retrospective study enrolled 345 patients. Immunohistochemical staining was performed on 55 normal endometrium (NE) samples, 27 atypical hyperplasia (AH) samples, and 263 type I EC samples. Read More

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November 2020

The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology.

Front Endocrinol (Lausanne) 2020 9;11:594370. Epub 2020 Oct 9.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.

Over the last years, increasing evidence has focused on crucial pathogenetic role of PRL on malignant, premalignant and benign uterine diseases. Studies in animals and humans have documented that PRL receptors (PRL-Rs) are widely expressed on uterine cells and that PRL is directly synthesized by the endometrium under the stimulatory action of progesterone. Uterine PRL secretion is finely modulated by autocrine/paracrine mechanisms which do not depend on the same control factors implied in the regulation of PRL secretion from pituitary. Read More

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A Novel Risk-Scoring Model for Prediction of Premalignant and Malignant Lesions of Uterine Endometrium Among Symptomatic Premenopausal Women.

Int J Womens Health 2020 27;12:883-891. Epub 2020 Oct 27.

Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Purpose: Uterine cancer is the second most prevalent cancer of the female genital tract, with 90% of it being of endometrial origin. The aim of this research was to create and validate a risk-scoring model using patients' clinical variables in predicting premalignant and malignant lesions of the uterine endometrium among premenopausal women with abnormal uterine bleeding (AUB).

Methods: This is a retrospective cohort study conducted at a tertiary hospital of Southern India for a period of 5 years from July 2014 to August 2019, including women aged ≤55 years who had AUB and underwent endometrial biopsy. Read More

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October 2020

Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.

Am J Surg Pathol 2020 10;44(10):1429-1439

Departments of Pathology.

Background: Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions is often problematic because of the profound morphologic changes induced by progestin and the lack of established diagnostic criteria for progestin-treated residual AH.

Methods: We conducted a longitudinal study of 265 endometrial biopsies from 54 patients with a history of AH on progestin therapy. Read More

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October 2020

The impact of HPV-specific infection in women diagnosed with atypical glandular cells: Results from the HPV-AGC study.

Pathol Res Pract 2020 Nov 24;216(11):153184. Epub 2020 Aug 24.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy.

Objective: To evaluate the impact of various HPV types on the risk of developing lesions of the uterus (either uterine cervix and endometrium) in women diagnosed with "atypical glandular cells" (AGC) at Pap smear.

Methods: This is a multi-institutional retrospective study. Data of women diagnosed with AGC were retrospectively reviewed. Read More

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November 2020

Promotion of the occurrence of endometrioid carcinoma by S100 calcium binding protein P.

BMC Cancer 2020 Sep 3;20(1):845. Epub 2020 Sep 3.

Obstetrics and Gynecology Hospital, Fudan University, Postal address: 413 Zhaozhou Road, Shanghai, 200011, China.

Background: Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. Read More

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September 2020

Subcategorization of atypical glandular cells is useful to identify lesion site.

Diagn Cytopathol 2020 Dec 15;48(12):1224-1229. Epub 2020 Jul 15.

Department of Obstetrics and Gynecology, Kurume University, School of Medicine, Kurume, Japan.

Background: In the subcategorization of atypical glandular cells (AGCs), origin of cells should be mentioned to estimate lesion sites for diagnosis. However, cases without subcategorization are often encountered due to limited reproducibility. We evaluated whether the subcategorization of AGC based on the Bethesda terminology can estimate lesion sites. Read More

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December 2020

Atrophic endometrium in postmenopausal women referred to diagnostic hysteroscopy: a study to avoid unnecessary examinations.

Eur Rev Med Pharmacol Sci 2020 05;24(10):5217-5222

Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy.

Objective: Any diagnostic workup should be based on appropriateness criteria. Diagnostic hysteroscopy is a procedure widely used in endometrial pathology. Its high outpatient feasibility frequently leads to misuse. Read More

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Can we rely on blind endometrial curettage for complete removal of focal intrauterine lesion? A prospective clinical study.

J Gynecol Obstet Hum Reprod 2020 Apr 1;49(4):101696. Epub 2020 Feb 1.

Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.

Objective: To investigate the diagnostic and therapeutic efficiency of dilatation-curettage (D&C) combined with aspiration curettage for endometrial pathology compared to hysteroscopy alone in this study.

Material And Methods: A total of 143 patients who have suspicion of endometrial mass like lesion, increased endometrial thickness (>5-mm at menopause and/or endometrial thickness upper than 5-mm in patients under tamoxifen treatment due to breast cancer during 2-D transvaginal ultrasonography examination) were enrolled. All patients underwent procedures in order of hysteroscopy, D&C plus aspiration and second look hysteroscopy. Read More

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Endometrioid Tubal Intraepithelial Neoplasia (E-TIN) of the Fallopian Tube: A Case Series.

Int J Gynecol Pathol 2020 Nov;39(6):552-557

Although serous tubal intraepithelial carcinoma has been well described in the distal fallopian tube as precancers of pelvic high-grade serous carcinoma, endometrioid precancers have drawn less attention. Recently, endometrioid precursor lesions have been identified and reported to have a specific immunophenotype (PAX2-, ALDH1+, diffuse nuclear beta-catenin), as well as an association with both uterine and ovarian endometrioid carcinomas. These have been referred to as endometrioid (or type II) secretory cell outgrowths. Read More

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November 2020

The Value of DNA Quantitative Cytology Test for the Screening of Endometrial Cancer.

Cancer Manag Res 2019 11;11:10383-10391. Epub 2019 Dec 11.

Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, People's Republic of China.

Objective: To evaluate the accuracy, sensitivity, and specificity of DNA quantitative cytology test for the diagnosis of endometrial cancer or precancerous lesions and then discuss the value of DNA quantitative cytology as a screening tool for endometrial cancer.

Methods: The study enrolled 575 patients from September 2013 to January 2017 in Shanghai Minhang Central Hospital. Endometrial hysteroscopy plus dilation and curettage and DNA quantitative cytology tests were conducted as a method for the diagnosis of endometrial cancer. Read More

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December 2019

Endometriosis-related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions.

Histopathology 2020 Jan;76(1):76-92

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Endometriosis is an extremely common condition and, in most cases, establishing a histological diagnosis is straightforward, although a variety of benign alterations may result in problems with interpretation. In this review, I discuss selected uncommon variants of endometriosis or benign alterations that may result in diagnostic problems. The topics covered include the contentious issue of so-called atypical endometriosis, stromal endometriosis, polypoid endometriosis, and the association of endometriosis with florid mesothelial hyperplasia. Read More

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January 2020

Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer That Is Associated with Poor Outcomes in Endometrial Carcinoma.

Int J Environ Res Public Health 2019 11 20;16(23). Epub 2019 Nov 20.

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Background: Pyruvate kinase M2 (PKM2) is a regulator of the processes of glycolysis and oxidative phosphorylation, but the roles that it plays in endometrial cancer remain largely unknown. This study evaluated the PKM2 expression in normal endometrium, endometrial hyperplasia, and endometrial carcinoma, and its prognostic value was investigated in endometrial carcinoma patients.

Methods: A hospital-based retrospective review was conducted to examine the immunohistochemical PKM2 distribution in 206 endometrium samples from biopsies or hysterectomies. Read More

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November 2019

Ultrasonic and Histopathological Evaluation to Exclude Premalignant and Malignant Lesions in Perimenopausal and Postmenopausal Women Presenting as Abnormal Uterine Bleeding.

J Obstet Gynaecol India 2019 Oct 21;69(Suppl 2):171-176. Epub 2018 Aug 21.

4Biostatics, IGIMS, Patna, India.

Introduction: Abnormal uterine bleeding may be defined as bleeding pattern that differs in frequency, duration and amount from a pattern observed during a normal menstrual cycle or after menopause.

Aim And Objective: The aim of this study was (1) to identify the different benign, premalignant and malignant conditions as the cause of abnormal uterine bleeding in perimenopausal and postmenopausal women and (2) to find out the different histopathological patterns of endometrium and cervix in these women.

Materials And Methods: This is a prospective study done in gynaecological oncology in 100 cases attending the OPD. Read More

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October 2019