4,384 results match your criteria Preimplantation Genetic Diagnosis


Metabolic characterization of amniotic fluids of fetuses with enlarged nuchal translucency.

J Perinat Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Microcitemico, Via E. Jenner n/n, 09121 Cagliari, Italy.

Background In prenatal diagnosis, a thickened nuchal translucency (NT) is one of the most sensitive and specific markers for several defects but it may also be found in 5% of healthy fetuses. The pathophysiological causes that lead to an increase in NT are not yet fully understood. Metabolomics represents a new promising approach, useful for studying different metabolites in biological organisms in response to environmental stressors. Read More

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http://dx.doi.org/10.1515/jpm-2018-0314DOI Listing
February 2019

Preimplantation genetic testing using Karyomapping for a paternally inherited reciprocal translocation: a case study.

J Assist Reprod Genet 2019 Feb 12. Epub 2019 Feb 12.

Monash IVF, Suite 1, 252 Clayton Rd, Clayton, Victoria, 3168, Australia.

Purpose: Preimplantation genetic testing (PGT) using Karyomapping is used to screen embryos for single gene disorders prior to implantation. While Karyomapping is not designed to screen for abnormalities in chromosome copy number, this testing is based upon a genome-wide analysis of single nucleotide polymorphisms (SNP) and, as such, some chromosome abnormalities are detected. The aim of this study was to validate whether Karyomapping could provide reliable and accurate PGT for a paternal 46,XY,t(10;19)(p15;p13. Read More

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http://dx.doi.org/10.1007/s10815-019-01413-0DOI Listing
February 2019

[Comparison of birth weights of children born after slow frozen embryo replacement versus fresh embryo transfer].

Gynecol Obstet Fertil Senol 2019 Feb 8. Epub 2019 Feb 8.

Département de biologie de la reproduction, CHU de Montpellier, 34000 Montpellier, France; Inserm, U1203, institut de médecine régénératrice et de biothérapie, CHU de Montpellier, 34000 Montpellier, France.

Objective: It is already known that children born after slow frozen embryo replacement have a significantly higher birth weight compared to children born after fresh embryo transfer. Similar data have been reported related to frozen embryo transfer using an open vitrification system. However, few data relative to birth weight using a complete embryo closed vitrification system has been reported. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.01.011DOI Listing
February 2019
1 Read

Preimplantation embryos sex ratios in couples with four or more children of same sex, what should be expected from a preimplantation genetic diagnosis cycle?

Gynecol Endocrinol 2019 Feb 10:1-3. Epub 2019 Feb 10.

a Department of Obstetrics and Gynecology , Sheba Medical Center , Ramat-Gan , Israel.

Our aim was to assess the preimplantation embryos' sex ratios in couples with four or more children of same sex, undergoing sex selection for nonmedical reasons. We conducted a cohort-historical study of all consecutive patients admitted to the IVF-PGD program in a large tertiary center. We reviewed the computerized files of all consecutive women admitted to our IVF for sex selection for nonmedical reasons. Read More

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http://dx.doi.org/10.1080/09513590.2018.1563886DOI Listing
February 2019

The aims of expanded universal carrier screening: Autonomy, prevention, and responsible parenthood.

Bioethics 2019 Feb 7. Epub 2019 Feb 7.

CAPHRI School for Public Health and Primary Care, Maastricht University, Netherlands.

Expanded universal carrier screening (EUCS) entails a population-wide screening offer for multiple disease-causing mutations simultaneously. Although there is much debate about the conditions under which EUCS can responsibly be introduced, there seems to be little discussion about its aim: providing carrier couples with options for autonomous reproductive choice. While this links in with current accounts of the aim of foetal anomaly screening, it is different from how the aim of ancestry-based carrier screening has traditionally been understood: reducing the disease burden in the population. Read More

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http://dx.doi.org/10.1111/bioe.12555DOI Listing
February 2019
1 Read

Risk Assessment for Huntington's Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners.

J Huntingtons Dis 2019 ;8(1):71-78

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Amongst the main reasons people at risk for Huntington's disease (HD) have for undergoing predictive genetic testing are planning a family and prevention of passing on an expanded CAG-repeat to future offspring. After having received an unfavourable test result, a couple may consider prenatal testing in the foetus or preimplantation genetic diagnostic testing (PGD) in embryos. Testing of the foetus or embryos is possible by means of direct testing of the expanded repeat. Read More

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http://dx.doi.org/10.3233/JHD-180314DOI Listing
January 2019
1 Read

[Preimplantation genetic diagnosis (PGD) in the era of predictive medicine].

Med Sci (Paris) 2019 Jan 23;35(1):72-77. Epub 2019 Jan 23.

Institut Éthique, Histoire, Humanités (iEH2), université de Genève, CMU, 1 rue Michel-Servet, CP 1211 Genève 4, Suisse.

High speed sequencing is revolutionizing the various genetic tests and in particular preimplantation genetic diagnosis (PGD), opening the doors to an increasingly efficient predictive medicine. PGD itself is not new, and the various legistations have been dealing with it for some twenty years. National ethics committees, for their part, have widely debated antenatal tests in the context of medically assisted procreation. Read More

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https://www.medecinesciences.org/10.1051/medsci/2018292
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http://dx.doi.org/10.1051/medsci/2018292DOI Listing
January 2019
4 Reads

Exploring the preferences of involved health professionals regarding the implementation of an online decision aid to support couples during reproductive decision-making in hereditary cancer: a mixed methods approach.

Fam Cancer 2019 Jan 17. Epub 2019 Jan 17.

Department of Clinical Genetics, Maastricht University Medical Centre+, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.

To support persons having a genetic predisposition to cancer and their partners during reproductive decision-making, an online decision aid was developed and evaluated. To maximize the impact of the support tool, this mixed methods study aims at developing the optimal implementation strategy for the decision aid. A questionnaire to assess the critical determinants that may affect this implementation was completed by health professionals involved in oncogenetic counselling (N = 46). Read More

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http://dx.doi.org/10.1007/s10689-019-00119-7DOI Listing
January 2019
4 Reads

Preimplantation genetic diagnosis in early pregnancy loss.

Semin Perinatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, 5 Columbus Circle, PH New York, NY 10019, USA.

Miscarriage is a frequent outcome seen in obstetrics with 1 in 5 pregnancies ending in an early pregnancy loss. Aneuploidy is the most significant single factor affecting early pregnancy failure and miscarriage. The risk of aneuploidy increases significantly with increasing maternal age. Read More

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http://dx.doi.org/10.1053/j.semperi.2018.12.009DOI Listing
December 2018
3 Reads

Sperm preservation by electroejaculation before anticancer therapy.

Scand J Urol 2019 Jan 17:1-3. Epub 2019 Jan 17.

a Department of Urology , Aarhus University Hospital , Denmark.

Background: This report presents a case where electroejaculation (EEJ) was used for semen cryopreservation (SCP), prior to gonadotoxic anti-cancer treatment in a 14-year old boy diagnosed with Hodgkins disease.

Method: Two sessions of EEJ were performed with an interval of 48 hours.

Results: No complications were seen and the procedures resulted in nine frozen straws of motile spermatozoa. Read More

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https://www.tandfonline.com/doi/full/10.1080/21681805.2018.1
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http://dx.doi.org/10.1080/21681805.2018.1534883DOI Listing
January 2019
4 Reads

Incidence and origin of meiotic whole and segmental chromosomal aneuploidies detected by karyomapping.

Reprod Biomed Online 2018 Dec 23. Epub 2018 Dec 23.

Repromeda, Clinic for Reproductive Medicine and Preimplantation Genetic Diagnosis, Biology Park, Studentská 812/6, 625 00 Brno, Czech Republic.

Research Question: What is the incidence and origin of meiotic whole and segmental aneuploidies detected by karyomapping at a blastocyst stage in human-derived IVF embryos? What is the distribution of various types of errors, including rare chromosomal abnormalities?

Design: The incidence of chromosomal aneuploidies was assessed in 967 trophectoderm biopsies from 180 couples who underwent 215 cycles of IVF with preimplantation genetic testing for monogenetic disease with a known causal mutation with a mean maternal age of 32.7 years. DNA from both parents and a reference sample was genotyped together with the analysed trophectoderm samples by karyomapping (single-nucleotide-polymorphism-based array). Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.023DOI Listing
December 2018
2 Reads

Inverse PCR to perform long-distance haplotyping: main applications to improve preimplantation genetic diagnosis in hemophilia.

Eur J Hum Genet 2019 Jan 9. Epub 2019 Jan 9.

Instituto de Medicina Experimental (IMEX), CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina.

Among other applications of long-distance haplotype phasing in clinical genetics, determination of linked DNA markers as surrogate for problematic structural variants (e.g., repeat-mediated rearrangements) is essential to perform diagnosis from low-quality DNA samples. Read More

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http://www.nature.com/articles/s41431-018-0334-9
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http://dx.doi.org/10.1038/s41431-018-0334-9DOI Listing
January 2019
6 Reads

The decision on the embryo to transfer after Preimplantation Genetic Diagnosis for X-autosome reciprocal translocation in male carrier.

Mol Cytogenet 2018 29;11:63. Epub 2018 Dec 29.

Unità di Medicina della Riproduzione - Centro HERA, via Barriera del Bosco n 51/53 95030 Sant Agata Li Battiati, Catania, Italy.

Background: The aim of Preimplantation Genetic Diagnosis (PGD) on embryos produced is to identify the embryos without genetic or chromosomal defect from those embryos that will develop the genetic disease or are chromosomally abnormal. In case of PGD for structural chromosome indication (PGR-SR), the normal/balanced embryos are transferred in the maternal uterus. This protocol is valid and widely applied for autosomal chromosome translocation. Read More

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http://dx.doi.org/10.1186/s13039-018-0409-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310935PMC
December 2018
2 Reads

Preimplantation genetic testing for monogenic diseases: a Brazilian IVF centre experience.

JBRA Assist Reprod 2019 Jan 7. Epub 2019 Jan 7.

Fertility - Medical Group, São Paulo, SP - Brazil.

Objective: To describe the cases of preimplantation genetic testing for monogenic diseases (PGT-M) in fertile couples who had undergone intracytoplasmic sperm injection (ICSI) cycles in a Brazilian fertilisation (IVF) centre and determine whether these cases were different from those reported from the European Society of Human Reproduction and Embryology (ESHRE).

Methods: This retrospective collection included data obtained from ICSI-PGT-M cycles between 2011 and 2016. The disease indication, number of biopsied embryos, biopsy stage, diagnosed and affected embryos, and cycles with embryo to transfer as well as implantation, pregnancy and miscarriage rates were analysed and compared to cycles without genetic diagnosis (PGT) and with ESHRE PGD Consortium collection XIV-XV. Read More

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http://www.gnresearch.org/doi/10.5935/1518-0557.20180076
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http://dx.doi.org/10.5935/1518-0557.20180076DOI Listing
January 2019
4 Reads

Prenatal genetic testing and treatment for congenital adrenal hyperplasia.

Fertil Steril 2019 Jan;111(1):21-23

Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida; Reproductive Genetic Innovations, LLC, Northbrook, Illinois.

Couples at risk for autosomal recessive congenital adrenal hyperplasia often request anticipatory guidance and genetic counseling. Initially, hormones in amniotic fluid were measured to distinguish affected female fetuses from unaffected fetuses. With the molecular era, more-targeted approaches became possible. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.11.041DOI Listing
January 2019
1 Read

Preimplantation genetic diagnosis and screening (PGD/S) using a semiconductor sequencing platform.

Hum Genomics 2019 Jan 3;13(1). Epub 2019 Jan 3.

Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University) Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.

Background: Recent advances in semiconductor sequencing platform (SSP) have provided new methods for preimplantation genetic diagnosis/screening (PGD/S). The present study aimed to evaluate the applicability and efficiency of SSP in PGD/S.

Methods: The artificial positive single-cell-like DNAs and normal single-cell samples were chosen to test our semiconductor sequencing platform for preimplantation genetic diagnosis/screening (SSP-PGD/S) method with two widely used whole-genome amplification (WGA) kits. Read More

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http://dx.doi.org/10.1186/s40246-018-0187-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318931PMC
January 2019
1 Read

Who Should Regulate Preimplantation Genetic Diagnosis in the United States?

AMA J Ethics 2018 Dec 1;20(12):E1160-1167. Epub 2018 Dec 1.

Unlike in many European countries, preimplantation genetic diagnosis (PGD) is not regulated in the United States. As a result, PGD may be used for any condition for which genetic testing is available, at the discretion of fertility specialists and their patients. This essay explores the question of who should be responsible for regulating PGD in the United States. Read More

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https://journalofethics.ama-assn.org/article/who-should-regu
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http://dx.doi.org/10.1001/amajethics.2018.1160DOI Listing
December 2018
1 Read

Why We Should Defend Gene Editing as Eugenics.

Authors:
Nicholas Agar

Camb Q Healthc Ethics 2019 Jan;28(1):9-19

This paper considers the relevance of the concept of "eugenics,"-a term associated with some of the most egregious crimes of the twentieth century-to the possibility of editing human genomes. The author identifies some uses of gene editing as eugenics but proposes that this identification does not suffice to condemn them. He proposes that we should distinguish between "morally wrong" practices, which should be condemned, and "morally problematic" practices that call for solutions, and he suggests that eugenic uses of gene editing fall into this latter category. Read More

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http://dx.doi.org/10.1017/S0963180118000336DOI Listing
January 2019
1 Read

27 years of prenatal diagnosis for Huntington disease in the United Kingdom.

Genet Med 2018 Dec 14. Epub 2018 Dec 14.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Purpose: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced.

Methods: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. Read More

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http://dx.doi.org/10.1038/s41436-018-0367-zDOI Listing
December 2018
11 Reads

Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles.

Taiwan J Obstet Gynecol 2018 Dec;57(6):858-861

Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan.

Objective: It is known that embryos with faster growing potential, especially in blastocyst development, correlate with the increased euploid rate. Our study investigated the preimplantation genetic screening cycle to analyze the correlation between early blastulation (EB) on day 4 embryo and the euploid rate.

Materials And Methods: This is a retrospective study examining 273 biopsied blastocysts after preimplantation genetic screening obtained from 54 patients from March 2013 to March 2017. Read More

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http://dx.doi.org/10.1016/j.tjog.2018.10.016DOI Listing
December 2018
2 Reads

Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More

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http://dx.doi.org/10.1186/s12958-018-0414-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282265PMC
December 2018
2 Reads

Detection of Aneuploidy and Unbalanced Rearrangements Using Comparative Genomic Hybridization Microarrays.

Methods Mol Biol 2019 ;1885:73-84

Igenomix, Valencia, Spain.

Comparative genomic hybridization arrays (aCGH) allow the analysis of all 24 chromosome aneuploidies and chromosome rearrangements in the same single (or few) biopsied cells in a short period (less than 24 h). When applied to preimplantation genetic diagnosis (PGD) and screening (PGS) this technique can improve the selection of embryos for transfer and therefore also the reproductive outcomes. In this chapter, we describe the CGH microarray protocol for PGS and PGD used in our laboratory. Read More

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http://link.springer.com/10.1007/978-1-4939-8889-1_5
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http://dx.doi.org/10.1007/978-1-4939-8889-1_5DOI Listing
January 2019
1 Read

Molecular Testing for Preimplantation Genetic Diagnosis of Single Gene Disorders.

Methods Mol Biol 2019 ;1885:61-71

Thomas Jefferson University, Basking Ridge, NJ, USA.

Preimplantation genetic testing has evolved tremendously from the early days of FISH detection for a select few chromosome aneuploidies to now combining the detection of all whole chromosome imbalances in conjunction with single gene disorder testing for inherited diseases. As universal carrier screening and exome or genome studies become more commonplace, more and more families are becoming interested in reducing the risk of having a child with a severe disease using preimplantation genetic testing. We describe here the use of quantitative PCR (qPCR) for the custom construction of single gene disorder testing plans for families, the validation of the probes designed, and the protocol for diagnosing an embryo biopsy. Read More

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http://dx.doi.org/10.1007/978-1-4939-8889-1_4DOI Listing
January 2019
5 Reads

Overview of Preimplantation Genetic Diagnosis (PGD): Historical Perspective and Future Direction.

Methods Mol Biol 2019 ;1885:23-43

Florida International University, Miami, FL, USA.

Preimplantation genetic diagnosis (PGD) can be considered the earliest form of prenatal testing. It was first used in humans over 26 years ago. At its inception, PGD could only be performed for a limited number of genetic disorders. Read More

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http://dx.doi.org/10.1007/978-1-4939-8889-1_2DOI Listing
January 2019
1 Read

[Analysis of chromosomes of embryos derived from translocation carriers during preimplantation genetic diagnosis cycles].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):875-878

Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Fuzong Clinical College of Fujian Medical University, Dongfang Hospital Affiliated to Xiamen University, Fuzhou, Fujian 350025, China.

Objective: To explore the effect of chromosomal translocations on the composition of embryonic chromosomes and its mechanism.

Methods: For 52 couples with one partner carrying a chromosomal translocation, results of next generation sequencing of all embryos derived from 61 cycles were divided into different groups based on the type of translocations, gender of the carrier, and maternal age. Effect of parental chromosomal translocations on the composition of embryonic chromosomes of each group was analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.06.024DOI Listing
December 2018
10 Reads

Karyomapping for simultaneous genomic evaluation and aneuploidy screening of preimplantation bovine embryos: The first live-born calves.

Theriogenology 2019 Feb 16;125:249-258. Epub 2018 Nov 16.

School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NH, UK. Electronic address:

In cattle breeding, the development of genomic selection strategies based on single nucleotide polymorphism (SNP) interrogation has led to improved rates of genetic gain. Additionally, the application of genomic selection to in-vitro produced (IVP) embryos is expected to bring further benefits thanks to the ability to test a greater number of individuals before establishing a pregnancy and to ensure only carriers of desirable traits are born. However, aneuploidy, a leading cause of developmental arrest, is known to be common in IVP embryos. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2018.11.014DOI Listing
February 2019
1 Read

Refining the ethics of preimplantation genetic diagnosis: A plea for contextualized proportionality.

Bioethics 2019 Feb 26;33(2):294-301. Epub 2018 Nov 26.

Health, Ethics and Society, Maastricht University, Maastricht, Netherlands; GROW School for Oncology & Developmental Biology; CAPHRI School for Public Health & Primary Care, Maastricht University, Maastricht, Netherlands.

Many European countries uphold a 'high risk of a serious condition' requirement for limiting the scope of preimplantation genetic diagnosis (PGD). This 'front door' rule should be loosened to account for forms of PGD with a divergent proportionality. This applies to both 'added PGD' (aPGD), as an add-on to in vitro fertilization (IVF), and 'combination PGD' (cPGD), for a secondary disorder in addition to the one for which the applicants have an accepted PGD indication. Read More

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http://dx.doi.org/10.1111/bioe.12534DOI Listing
February 2019
3 Reads

Mutation analysis and pathogenicity identification of Mucopolysaccharidosis type IVA in 8 south China families.

Gene 2019 Feb 17;686:261-269. Epub 2018 Nov 17.

Department of Medical Genetics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Mucopolysaccharidosis type IVA (MPS IVA) is a rare autosomal recessive lysosomal storage disorder caused by GALNS gene mutation. The aim of our study is to detect pathogenic variants for patients suspected of MPS IVA and set the base for subsequent prenatal diagnosis and preimplantation genetic diagnosis.

Methods: In our study, 9 MPS IVA patients from south China families were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183119
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http://dx.doi.org/10.1016/j.gene.2018.11.051DOI Listing
February 2019
14 Reads

Haploseek: a 24-hour all-in-one method for preimplantation genetic diagnosis (PGD) of monogenic disease and aneuploidy.

Genet Med 2018 Nov 19. Epub 2018 Nov 19.

Translational Genomics Lab, Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel.

Purpose: To develop an economical, user-friendly, and accurate all-in-one next-generation sequencing (NGS)-based workflow for single-cell gene variant detection combined with comprehensive chromosome screening in a 24-hour workflow protocol.

Methods: We subjected single lymphoblast cells or blastomere/blastocyst biopsies from four different families to low coverage (0.3×-1. Read More

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http://dx.doi.org/10.1038/s41436-018-0351-7DOI Listing
November 2018
1 Read

Manipulation of Biological Cells Using a Robot-Aided Optical Tweezers System.

Micromachines (Basel) 2018 May 17;9(5). Epub 2018 May 17.

College of Automation Engineering, Nanjing University of Aeronautics & Astronautics, Nanjing 211106, China.

This article reviews the autonomous manipulation strategies of biological cells utilizing optical tweezers, mainly including optical direct and indirect manipulation strategies. The typical and latest achievements in the optical manipulation of cells are presented, and the existing challenges for autonomous optical manipulation of biological cells are also introduced. Moreover, the integrations of optical tweezers with other manipulation tools are presented, which broadens the applications of optical tweezers in the biomedical manipulation areas and will also foster new developments in cell-based physiology and pathology studies, such as cell migration, single cell surgery, and preimplantation genetic diagnosis (PGD). Read More

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http://www.mdpi.com/2072-666X/9/5/245
Publisher Site
http://dx.doi.org/10.3390/mi9050245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187456PMC
May 2018
12 Reads

Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations.

J Assist Reprod Genet 2018 Nov 12. Epub 2018 Nov 12.

IVF Lab & Wolfe PGD-Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, 6423906, Tel Aviv, Israel.

Purpose: The purpose of the study was to compare the morphokinetic parameters of embryos carrying balanced chromosomal translocations with those carrying unbalanced chromosomal translocations using time-lapse microscopy.

Methods: The study group included 270 embryos that underwent biopsies on day 3 for preimplantation genetic diagnosis (PGD) for chromosomal translocations in our unit between 2013 and 2015. All embryos were incubated under time-lapse microscopy and evaluated for timing of developmental events up to day 5. Read More

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http://dx.doi.org/10.1007/s10815-018-1361-8DOI Listing
November 2018
2 Reads

Cross-border preimplantation genetic diagnosis.

Reprod Biomed Soc Online 2018 Aug 25;6:22. Epub 2018 Sep 25.

Department of Pediatrics, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

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http://dx.doi.org/10.1016/j.rbms.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214834PMC
August 2018
1 Read

Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Trial of Synthetic Preimplantation Factor in Autoimmune Hepatitis.

Hepatol Commun 2018 Oct 26;2(10):1235-1246. Epub 2018 Sep 26.

University of Miami Schiff Center for Liver Diseases Miami Florida.

Preimplantation factor (PIF) is an evolutionary conserved peptide secreted by viable embryos which promotes maternal tolerance without immune suppression. Synthetic PIF (sPIF) replicates native peptide activity. The aim of this study was to conduct the first-in-human trial of the safety, tolerability, and pharmacokinetics of sPIF in patients with autoimmune hepatitis (AIH). Read More

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http://dx.doi.org/10.1002/hep4.1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218676PMC
October 2018
8 Reads