46,502 results match your criteria Pregnancy Preeclampsia


Bioinformatics-based screening of key genes between maternal preeclampsia and offspring schizophrenia.

Biochem Biophys Res Commun 2022 May 13;615:1-8. Epub 2022 May 13.

Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Converging lines of evidence suggest an association between schizophrenia and prenatal neurodevelopmental disorders. Preeclampsia is a multisystem disease based on the coexistence of pregnancy and elevated blood pressure, which increases the risk for offspring abnormal neurodevelopment. Previous studies have showed maternal preeclampsia is associated with an increased risk of offspring schizophrenia, but the molecular mechanism remains unclear. Read More

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Upregulation of METTL14 contributes to trophoblast dysfunction by elevating FOXO3a expression in an mA-dependent manner.

Placenta 2022 May 14;124:18-27. Epub 2022 May 14.

Department of Reproductive Medicine Center, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000, China. Electronic address:

Introduction: Preeclampsia, a specific complication of pregnancy, is a leading cause of perinatal and maternal mortality worldwide. N-methyladenosine (mA) is a prevalent and reversible modification of mammalian mRNAs, and is known to play an important role in various physiological and pathological processes. However, little is known about its possible effects on trophoblasts in preeclampsia. Read More

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Calcium for pre-eclampsia prevention: a systematic review and network meta-analysis to guide personalised antenatal care.

BJOG 2022 May 20. Epub 2022 May 20.

Department of Obstetrics and Gynaecology and British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Background: Calcium supplementation reduces the risk of pre-eclampsia, but questions remain about the dosage to prescribe and who would benefit most.

Objective: To evaluate the effectiveness of high- (≥1 g/d) and low-dose (<1 g/d) calcium for pre-eclampsia prevention, and according to baseline dietary calcium, pre-eclampsia risk, and co-interventions, and intervention timing.

Search Strategy: CENTRAL, PubMed, Global Index Medicus, and CINAHL from inception to Feb/2/2021, clinical trial registries, reference lists, and expert input (CRD42018111239). Read More

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The role of intervening pregnancy loss in the association between interpregnancy interval and adverse pregnancy outcomes.

BJOG 2022 May 20. Epub 2022 May 20.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Objective: To investigate whether intervening miscarriages and induced abortions impact the associations between interpregnancy interval after a live birth and adverse pregnancy outcomes.

Design: Population based cohort study.

Setting: Norway PARTICIPANTS: A total of 165,617 births to 143,916 women between 2008 and 2016 MAIN OUTCOME MEASURES: We estimated adjusted relative risks for adverse pregnancy outcomes using log-binomial regression, first ignoring miscarriages and induced abortions in the interpregnancy interval estimation (conventional interpregnancy interval estimates) and subsequently accounting for intervening miscarriages or induced abortions (correct interpregnancy interval estimates). Read More

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The association between maternal pre-pregnancy body mass index and pregnancy outcomes of preeclampsia.

Taiwan J Obstet Gynecol 2022 May;61(3):441-446

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: To evaluate the effects of pre-pregnancy maternal body mass index (BMI) to pregnancy outcomes in patients diagnosed as preeclampsia.

Materials And Methods: This was a retrospectively study on women who had been diagnosed as preeclampsia and delivered at Seoul National University Bundang Hospital between June 2017 and March 2020. Multifetal gestation, major fetal anomaly, and fetal death in utero were excluded. Read More

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Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation.

J Dev Orig Health Dis 2022 May 20:1-13. Epub 2022 May 20.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Children of women with pre-eclampsia have increased risk of cardiovascular (CV) and metabolic disease in adult life. Furthermore, the risk of pregnancy complications is higher in daughters born to women affected by pre-eclampsia than in daughters born after uncomplicated pregnancies. While aberrant inflammation contributes to the pathophysiology of pregnancy complications, including pre-eclampsia, the contribution of maternal inflammation to subsequent risk of CV and metabolic disease as well as pregnancy complications in the offspring remains unclear. Read More

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[Pregnancy after simultaneouspancreasandkidney transplantation].

Ugeskr Laeger 2022 May;184(19)

Institut for Klinisk Medicin, Aarhus Universitet.

In this case report, a 41-year-old nullipara obtained pregnancy one and a half year after a simultaneous pancreas and kidney transplantation (SKP). After SKP, the woman had no need for insulin and no hypertension. Her kidney function was stable during pregnancy and no insulin was needed. Read More

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Pregnancy and neonatal outcomes in women receiving calcineurin inhibitors: A systematic review and meta-analysis.

Br J Clin Pharmacol 2022 May 20. Epub 2022 May 20.

Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Aim: Calcineurin inhibitors (CNIs) are often used for solid organ transplantation recipients or patients with immune-mediated diseases. This systematic review and meta-analysis aims to understand how CNIs affect pregnancy and neonatal outcomes.

Methods: Electronic databases were searched for observational studies assessing pregnancy and neonatal outcomes in CNI-treated patients. Read More

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Cell-free plasma RNA signatures as a surrogate biomarker of pregnancy health.

Med (N Y) 2022 Feb;3(2):90-92

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA. Electronic address:

Molecular diagnostics based on sequencing of plasma cell-free DNA has transformed obstetric care by accurately diagnosing fetal aneuploidy in early pregnancy. Rasmussen et al. now report plasma cell-free RNA profiling that could transform obstetrics by providing comprehensive molecular monitoring of pregnancy progression for both healthy and complicated pregnancies such as preeclampsia. Read More

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February 2022

Integrated analysis of an in vivo model of intra-nasal exposure to instilled air pollutants reveals cell-type specific responses in the placenta.

Sci Rep 2022 May 19;12(1):8438. Epub 2022 May 19.

Division of Neonatology & Developmental Biology, Department of Pediatrics, and the UCLA Children's Discovery & Innovation Institute, David Geffen School of Medicine at University of California Los Angeles, 10883, Le Conte Avenue, MDCC-22-412, Los Angeles, CA, 90095-1752, USA.

The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. It maintains a critical balance between maternal and fetal homeostasis. Placental dysfunction can lead to adverse pregnancy outcomes including intra-uterine growth restriction, pre-eclampsia, or pre-term birth. Read More

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Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes.

Am J Hum Genet 2022 May 13. Epub 2022 May 13.

Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford School of Medicine, Stanford, CA 94305, USA.

Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity of preeclampsia poses a challenge for understanding its etiology and molecular basis. Intriguingly, risk for the condition increases in high-altitude regions such as the Peruvian Andes. Read More

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Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia.

J Extracell Vesicles 2022 May;11(5):e12217

Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.

Amniotic fluid surrounding the developing fetus is a complex biological fluid rich in metabolically active bio-factors. The presence of extracellular vesicles (EVs) in amniotic fluid has been mainly related to foetal urine. We here characterized EVs from term amniotic fluid in terms of surface marker expression using different orthogonal techniques. Read More

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Assessment of adherence to aspirin for preeclampsia prophylaxis and reasons for non-adherence.

Am J Obstet Gynecol MFM 2022 May 14:100663. Epub 2022 May 14.

Obstetrics and Gynecology Department, MetroHealth Medical Center of Case Western Reserve University. 2500 Metrohealth Dr. Cleveland, OH 44109.

Background: Preeclampsia is a hypertensive disease unique to pregnancy and has a significant impact on maternal and neonatal morbidity and mortality. Daily aspirin has been demonstrated to reduce the risk of preeclampsia. The American College for Obstetricians and Gynecologists (ACOG) recommends daily low-dose aspirin initiation, ideally prior to 16 weeks gestation, in at-risk patients for preeclampsia risk reduction. Read More

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Folic Acid Levels During Pregnancy Regulate Trophoblast Invasive Behavior and the Possible Development of Preeclampsia.

Front Nutr 2022 28;9:847136. Epub 2022 Apr 28.

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: One of the unique features of placentation is its similarity to tumorigenesis yet being very well regulated. It allows rapid proliferation, migration, and invasion of mononuclear trophoblast cells into the maternal uterus and remodeling the maternal vasculature. This pseudomalignant nature of trophoblastic cells is strictly regulated and its importance becomes evident in abnormal pregnancies that are characterized by aberrant trophoblast proliferation/invasion like preeclampsia. Read More

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Association between first birth caesarean delivery and adverse maternal-perinatal outcomes in the second pregnancy: a registry-based study in Northern Tanzania.

BMC Pregnancy Childbirth 2022 May 16;22(1):411. Epub 2022 May 16.

Kilimanjaro Christian Medical University College, P.O Box 2240, Moshi, Tanzania.

Background: Caesarean delivery (CD) is the commonest obstetric surgery and surgical intervention to save lives of the mother and/or the new-borns. Despite been accepted as safe procedure, caesarean delivery has an increased risk of adverse maternal and fetal outcomes. The rising rate of caesarean delivery has been a major public health concern worldwide and the consequences that come along with it urgently need to be assessed, especially in resource limited settings. Read More

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Association between obesity in women with polycystic ovary syndrome and adverse obstetric outcomes.

Reprod Biomed Online 2022 Feb 15. Epub 2022 Feb 15.

McGill University, McGill University Health Center, Reproductive Center, Department of Obstetrics and Gynecology, MUHC Reproductive center, McGill University, 888, Boulevard de Maisonneuve East, Suite 200, Montreal QC H2L 4S8, Canada. Electronic address:

Research Question: How does the presence of obesity modify the risks for adverse obstetric outcomes in women with polycystic ovary syndrome (PCOS)?

Design: Retrospective population-based cohort study using data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample, 2004-2014. A total of 14,855 women with PCOS were identified (study group: obese women with PCOS [BMI ≥30 kg/m] [n = 3286]; reference group: remaining women with PCOS [n =11 569]). Logistic regression analysis was used to explore the associations between obesity, pregnancy, delivery and neonatal outcomes. Read More

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February 2022

Folic Acid and Risk of Preterm Birth, Preeclampsia and Fetal Growth Restriction Among Women With Epilepsy: A Prospective Cohort Study.

Neurology 2022 May 16. Epub 2022 May 16.

Department of Clinical Medicine, University of Bergen, Norway.

Background And Objectives: Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction and preeclampsia. We aimed to investigate whether folic acid supplementation is associated with these pregnancy complications in women with epilepsy using ASM.

Methods: Singleton pregnancies in the prospective Norwegian Mother and Child Cohort Study (MoBa) (1999-2008) were included. Read More

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Guideline No. 426: Hypertensive Disorders of Pregnancy: Diagnosis, Prediction, Prevention, and Management.

J Obstet Gynaecol Can 2022 May;44(5):547-571.e1

Montreal, QC.

Objective: This guideline was developed by maternity care providers from obstetrics and internal medicine. It reviews the diagnosis, evaluation, and management of the hypertensive disorders of pregnancy (HDPs), the prediction and prevention of preeclampsia, and the postpartum care of women with a previous HDP.

Target Population: Pregnant women. Read More

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Functional and pathological role of 15-Lipoxygenase and its metabolites in pregnancy and pregnancy-associated complications.

Prostaglandins Other Lipid Mediat 2022 May 13:106648. Epub 2022 May 13.

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Maternal lipid metabolism status during pregnancy may have pivotal effects on a healthy pregnancy, the progression of labor, and childbirth. Based on evidence, changes in maternal lipid profile and metabolism is related to various alterations in fetal metabolic status, fat mass, birth weight and can result in serious maternal and fetal complications. 15-lipoxygenase accounts as a key enzyme in metabolizing polyunsaturated fatty acids that generate various inflammatory lipid metabolites. Read More

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MRI Changes Among Patients Of Eclampsia And Preeclampsia With Associated Neurological Symptom Analysis.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):269-272

Department of Medicine Ayub teaching hospital Abbottabad, Pakistan.

Background: Pregnancy poses some stress on normal homeostasis of the human body and brings changes in the body which predisposes the individual towards various pathological conditions as well.

Objective: Objective of the study was to determine the magnetic resonance imaging (MRI) changes and clinical symptoms associated with these changes among patients of eclampsia and preeclampsia managed at tertiary care unit. It was a cross-sectional study, conducted at Gynaecology and obstetrics department Pak Emirates Military Hospital (PEMH) Rawalpindi. Read More

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Maternal and neonatal outcomes of antihypertensive treatment in pregnancy: A retrospective cohort study.

PLoS One 2022 16;17(5):e0268284. Epub 2022 May 16.

Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, United States of America.

Objective: To compare maternal and infant outcomes with different antihypertensive medications in pregnancy.

Design: Retrospective cohort study.

Setting: Kaiser Permanente, a large healthcare system in the United States. Read More

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Pre-pregnancy fat intake in relation to hypertensive disorders of pregnancy.

Am J Clin Nutr 2022 May 16. Epub 2022 May 16.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Background: Many studies have linked intakes of fat and of specific fatty acids during pregnancy and preeclampsia, however the relation of intake before pregnancy with hypertensive disorders of pregnancy (HDP) is scant.

Objective: Evaluate intakes of major and specific types of fat before pregnancy with the risk of HDP: preeclampsia and gestational hypertension (GHTN).

Methods: We followed 11,535 women without chronic disease participating in the Nurses' Health Study-II from 1991 and 2009. Read More

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Multisystem inflammatory syndrome in children (MIS-C) in pregnancy can mimic new-onset pre-eclampsia: A case report.

Case Rep Womens Health 2022 Jul 10;35:e00420. Epub 2022 May 10.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Atrium Health, 1025 Morehead Medical Drive, Suite 500, Charlotte, NC 28204, USA.

Introduction: Pregnant women affected by coronavirus disease 2019 (COVID-19) are at increased risk of severe disease, admission to an intensive care unit, and adverse pregnancy outcomes. In contrast, children typically experience a mild form of COVID-19. Nonetheless, there is a risk of multisystem inflammatory syndrome in children (MIS-C) following a SARS-CoV-2 infection. Read More

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Editorial: Placental Hormones and Pregnancy-Related Endocrine Disorders.

Front Endocrinol (Lausanne) 2022 28;13:905829. Epub 2022 Apr 28.

Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

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Obesity and Maternal-Placental-Fetal Immunology and Health.

Front Pediatr 2022 28;10:859885. Epub 2022 Apr 28.

New York State Department of Health, Wadsworth Center, Albany, NY, United States.

Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports. It is known that obesity is associated with oxidative stress and inflammation, including disruptions in cellular function and cytokine levels. In pregnant women who are obese, associated placental dysfunction can lead to small for gestational age (SGA) infants. Read More

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Splenic B1 B Cells Acquire a Proliferative and Anti-Inflamatory Profile During Pregnancy in Mice.

Front Immunol 2022 28;13:873493. Epub 2022 Apr 28.

Laboratorio de Inmunología de la Reproducción, CEFYBO-UBA-CONICET, Buenos Aires, Argentina.

B cells are a heterogeneous cell population with differential ontogeny, anatomical location, and functions. B1 B cells are a distinct subpopulation characterized by their unique capacity of self-renewal, the production of large quantities of IL-10, and the ability to secrete protective, anti-inflammatory natural antibodies (NAbs), presumably upon down-regulation of CD1d expression. Although natural antibodies are thought to be protective, due to their polyreactivity, their participation in certain autoimmune diseases has been suggested. Read More

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Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes.

J Nutr Metab 2022 4;2022:4715965. Epub 2022 May 4.

Rowett Institute, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Background: Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes.

Materials And Methods: Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Read More

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Pre-eclampsia: a Scoping Review of Risk Factors and Suggestions for Future Research Direction.

Regen Eng Transl Med 2022 May 10:1-13. Epub 2022 May 10.

Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI USA.

Abstract: Most of maternal deaths are preventable, and one-quarter of maternal deaths are due to pre-eclampsia and eclampsia. Prenatal screening is essential for detecting and managing pre-eclampsia. However, pre-eclampsia screening is solely based on maternal risk factors and has low (< 5% in the USA) detection rates. Read More

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Human Leukocyte Antigens in Pregnancy and Preeclampsia.

Front Genet 2022 27;13:884275. Epub 2022 Apr 27.

Department of Pathology, University of California San Diego, San Diego, CA, United States.

Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-fetal interface. Human leukocyte antigens (HLA) are major histocompatibility complex molecules essential for the recognition of foreign antigens that is central to immune defense against pathogens and critical determinants for the immune system discriminating between self and non-self tissues, such as in transplantation. Pregnancy represents a naturally existing "transplantation", where the maternal immune system must be immunologically tolerant to the developing fetus which is 50% allogeneic. Read More

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