38,828 results match your criteria Pregnancy Preeclampsia


Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

J Photochem Photobiol B 2019 Mar 22;194:183-187. Epub 2019 Mar 22.

Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital of Shandong Province, Shandong, China. Electronic address:

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.013DOI Listing

CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34 + cell presence, and autophagy in the endometrium.

Biol Reprod 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA.

Placenta development is characterized by extensive angiogenesis and vascularization but if these processes are compromised placental dysfunction occurs, which is the underlying cause of pregnancy complications such as preeclampsia and intrauterine growth restriction. Dysregulation of placental angiogenesis has emerged as one of the main pathophysiological features in the development of placental insufficiency and its clinical consequences. The signaling axis initiated by chemokine ligand 12 (CXCL12) and its receptor CXCR4 stimulate angiogenesis in other tissues, and may be central to placental vascularization. Read More

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http://dx.doi.org/10.1093/biolre/ioz073DOI Listing

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study.

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Department of Obstetrics and Gynecology , KasrAlAini Hospital Cairo University , Cairo , Egypt.

This is a cohort study which included 100 cases with pre-eclampsia (PE) and 100 controls, done to compare the antepartum and postpartum uterine artery (UtA) Doppler velocimetry between them. UtA PI and RI were measured before and within 48-72 h after delivery. There was a highly significant difference between the cases and controls, regarding the UtA RI (0. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1563054DOI Listing
April 2019
1 Read

Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
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http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
1 Read

Memory T Cells in Pregnancy.

Front Immunol 2019 2;10:625. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Adaptations of the maternal immune response are necessary for pregnancy success. Insufficient immune adaption is associated with pregnancy pathologies such as infertility, recurrent miscarriage, fetal growth restriction, spontaneous preterm birth, and preeclampsia. The maternal immune system is continuously exposed to paternal-fetal antigens; through semen exposure from before pregnancy, through fetal cell exposure in pregnancy, and through microchimerism after pregnancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00625
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http://dx.doi.org/10.3389/fimmu.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455355PMC
April 2019
1 Read

Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Human placenta development and a successful pregnancy is incumbent upon precise oxygen-dependent control of trophoblast migration/invasion. Persistent low oxygen leading to failed trophoblast invasion promotes inadequate spiral artery remodeling, a characteristic of preeclampsia. Angiomotin (AMOT) is a multifaceted scaffolding protein involved in cell polarity and migration, yet its upstream regulation and significance in the human placenta remain unknown. Read More

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https://insight.jci.org/articles/view/127009
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http://dx.doi.org/10.1172/jci.insight.127009DOI Listing
April 2019
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Comparing pregnancy outcomes and loss rates in elective twin pregnancy reduction to ongoing twin gestations in a large contemporary cohort.

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: As compared to singleton gestations, twin pregnancies are associated with a significantly higher risk of preterm birth, maternal complications, as well as fetal and neonatal morbidity and mortality. Multifetal pregnancy reduction (MPR) is a technique developed in the 1980s to reduce the fetal number in higher-order multiple pregnancies to reduce the risk of adverse pregnancy outcomes, most importantly preterm birth.

Objective: To compare pregnancy outcomes and loss rates in elective twin pregnancy reduction to ongoing twin gestations in a large contemporary cohort. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.001DOI Listing
April 2019
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Dyslipidemia and the role of the adipose tissue in early pregnancy in the BPH/5 mouse model for preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Clinical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, United States.

Background: The hypertensive pregnancy disorder preeclampsia (PE) is a leading cause of fetal/ maternal morbidity/mortality. Obesity increases the risk to develop PE, presumably via the release of inflammatory mediators from the adipose tissue, but the exact etiology remains largely unknown.

Methods: Using obese PE-like BPH/5 and lean gestational age-matched C57Bl6 mice, we aimed to obtain insight into differential reproductive white adipose tissue (rWAT) gene expression, circulating lipids and inflammation at the maternal-fetal interface during early pregnancy. Read More

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http://dx.doi.org/10.1152/ajpregu.00334.2018DOI Listing
April 2019
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Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.

Ann N Y Acad Sci 2019 Apr 17. Epub 2019 Apr 17.

Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.

Maternal anemia is a well-recognized global health problem; however, there remain questions on specific hemoglobin (Hb) thresholds that predict health risk or protection for mother and child. We conducted a systematic review and meta-analysis to examine the associations of maternal Hb concentrations with a range of maternal and infant health outcomes, accounting for the timing of measurement (preconception, and first, second, and third trimesters), etiology of anemia, and cutoff category. The systematic review included 272 studies and the meta-analysis included 95 studies. Read More

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http://dx.doi.org/10.1111/nyas.14093DOI Listing
April 2019
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Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the 'DO' component of DOHaD.

J Dev Orig Health Dis 2019 Apr;10(2):141-143

1Department of Obstetrics and Gynaecology, Maternal Fetal Medicine Unit,The Aga Khan University,Karachi,Pakistan.

Adverse intrauterine environment could serve as an important stimulus for postnatal altered health status and for increased susceptibility to long-term non-communicable diseases (NCDs). The notion is now recognized as the Developmental Origins of Health and Disease (DOHaD), which was first proposed by Sir David Barker. Since then, several scientific disciplines have strived to measure the magnitude of the early fetal programming and later risk of diseases. Read More

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http://dx.doi.org/10.1017/S2040174418000636DOI Listing
April 2019
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The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies.

Int J Obes (Lond) 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Objecive: Women with twins have an a priori increased risk for many of the complications associated with maternal obesity. Thus, the impact of maternal obesity in twins may differ from that reported in singletons. In addition, given the increased metabolic demands in twin pregnancies, the impact of maternal underweight may be greater in twin compared with singleton gestations. Read More

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http://dx.doi.org/10.1038/s41366-019-0362-8DOI Listing
April 2019
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Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration.

Int J Womens Health 2019 27;11:213-222. Epub 2019 Mar 27.

Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland,

Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications of pregnancy. Previous studies by our group have shown that PP13 lowers blood pressure in pregnant rats, increases the size and weight of pups and placentas, and induces vasodilation of resistance arteries through endothelial signaling pathways involving endothelial nitric oxid synthase and prostaglandin.

Methods: In the present study, the effect of PP13 was investigated in nonpregnant female Sprague Dawley rats (n=27). Read More

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https://www.dovepress.com/placental-protein-13-pp13-stimulat
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http://dx.doi.org/10.2147/IJWH.S188303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443218PMC
March 2019
2 Reads

Perspectives and pregnancy outcomes of maternal Ramadan fasting in the second trimester of pregnancy.

BMC Pregnancy Childbirth 2019 Apr 15;19(1):128. Epub 2019 Apr 15.

Department of Basic Science, College of Basic Science, Hawler Medical University, Erbil, Iraq.

Background: There are controversies over the effects of Ramadan fasting on pregnancy outcomes, and women's perspectives of fasting are diverse. This study aimed to assess the perspectives and pregnancy outcomes of maternal Ramadan fasting in the second trimester of pregnancy.

Methods: A case-control study was conducted at Hawler Maternity Teaching Hospital of Erbil, Iraq from October 2017 to January 2018. Read More

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http://dx.doi.org/10.1186/s12884-019-2275-xDOI Listing
April 2019
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Practical approach to the prevention of preeclampsia: from screening to pharmaceutical intervention.

J Matern Fetal Neonatal Med 2019 Apr 15:1-7. Epub 2019 Apr 15.

a Weill Cornell Medicine in Qatar , Doha , Qatar.

Preeclampsia occurs in 3-8% of the pregnancies and is associated with a high rate of morbi-mortality, both for mothers and the fetus. Screening and prevention of patients at risk are the optimal way to reduce the morbi-mortality of this disease. To set-up a preventive approach to preeclampsia (PE), one has to identify using a screening strategy for the population at risk and propose them an appropriate therapeutic intervention that would bear a favorable benefits/risk ratio. Read More

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http://dx.doi.org/10.1080/14767058.2019.1588877DOI Listing
April 2019
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IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Placenta Lab, Department of Obstetrics, Jena University Hospital, 07740 Jena, Germany.

The IL-36 subfamily of cytokines has been recently described as part of the IL-1 superfamily. It comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), their receptor (IL-36R), and one antagonist (IL-36Ra). Although expressed in a variety of cells, the biological relevance of IL-36 cytokines is most evident in the communication between epithelial cells, dendritic cells, and neutrophils, which constitute the common triad responsible for the initiation, maintenance, and expansion of inflammation. Read More

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http://dx.doi.org/10.3390/ijms20071649DOI Listing
April 2019
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Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India.

Gene 2019 Apr 12;704:68-73. Epub 2019 Apr 12.

Department of Anthropology, University of Delhi, Delhi, India. Electronic address:

Aim: The purpose of the present study is to evaluate and understand the association of global and MTHFR gene specific methylation in preeclampsia and recurrent miscarriages in light of MTHFR C677T polymorphism.

Methods: The subjects comprised of recurrent miscarriage cases, their gestation matched controls, preeclampsia cases and matched controls. A set of women at full term were also recruited. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.036DOI Listing
April 2019
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Therapeutic Implications of Inherited Thrombophilia in Pregnancy.

Am J Ther 2019 Apr 12. Epub 2019 Apr 12.

University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Background: Inherited (hereditary) thrombophilia is a genetic disorder that affects coagulation, being responsible for more than 60% of idiopathic (spontaneous or unprovoked) thromboembolic events. Association of inherited thrombophilia with pregnancy increases the risk of thromboembolic disease, and it may be related to many complications, such as preeclampsia, recurrent miscarriage intrauterine growth restriction, early detachment of placenta, and prematurity.

Areas Of Uncertainty: Interpretation of a positive test for thrombophilia in pregnant women is difficult because they have many natural changes in the coagulation system. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000985DOI Listing
April 2019
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Vitamin D status in pregnant women visiting a tertiary care center of North Eastern India.

J Family Med Prim Care 2019 Feb;8(2):356-360

Department of Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Studies of vitamin D (VD) physiology suggest that effects of vitamin D deficiency (VDD) could be much broader than rickets including cardiovascular disease, cancers, diabetes, infection, and allergy and pregnancy complications. Data regarding the prevalence of hypovitaminosis in pregnancy are scanty especially in north eastern part of India. Therefore, this study has undertaken with the intention to find out prevalence and outcome of hypovitaminosis of VD in pregnancy. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_404_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436274PMC
February 2019
1 Read

Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges.

Front Immunol 2019 21;10:478. Epub 2019 Mar 21.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Inflammation is a central feature and is implicated as a causal factor in preeclampsia and other hypertensive disorders of pregnancy. Inflammatory mediators and leukocytes, which are elevated in peripheral blood and gestational tissues, contribute to the uterine vascular anomalies and compromised placental function that characterize particularly the severe, early onset form of disease. Regulatory T (Treg) cells are central mediators of pregnancy tolerance and direct other immune cells to counteract inflammation and promote robust placentation. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00478
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http://dx.doi.org/10.3389/fimmu.2019.00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448013PMC
March 2019
2 Reads

Platelet function in preeclampsia - a systematic review and meta-analysis.

Platelets 2019 Apr 14:1-14. Epub 2019 Apr 14.

a Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Preeclampsia is a serious pregnancy-related complication. Platelets are potentially important in the pathogenesis of preeclampsia, and platelet function analyses may prove as sensitive preeclampsia biomarkers. This study aimed to systematically review and summarise the literature on platelet function markers in preeclampsia. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595561DOI Listing
April 2019
1 Read

Dietary patterns before and during pregnancy and maternal outcomes: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):705S-728S

Food and Nutrition Service, USDA, Alexandria, VA.

Background: Hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) are common maternal complications during pregnancy, with short- and long-term sequelae for both mothers and children.

Objective: Two systematic review questions were used to examine the relation between 1) dietary patterns before and during pregnancy, 2) HDP, and 3) GDM.

Methods: A search was conducted from January 1980 to January 2017 in 9 databases including PubMed, Embase, and Cochrane. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcn/nqy216DOI Listing
March 2019
3 Reads
6.770 Impact Factor

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.

Am J Nephrol 2019 Apr 12;49(5):386-396. Epub 2019 Apr 12.

Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara Health Sciences Center, Guadalajara, Mexico,

Background: Chronic kidney disease (CKD) is a global public health problem and is linked to adverse outcomes during pregnancy; the high prevalence of CKD (3-6%) in women of childbearing age is of particular relevance in emerging countries where CKD prevalence is higher and resources are limited. Although CKD is a public health problem in Mexico, there is scant information on outcomes in pregnant CKD women in this country. We report maternal-fetal outcomes in a prospective cohort of poor, CKD pregnant women, and compare results with those of pregnant women without CKD. Read More

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https://www.karger.com/Article/FullText/499964
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http://dx.doi.org/10.1159/000499964DOI Listing
April 2019
2 Reads

Translating Maternal Mortality Review Into Quality Improvement Opportunities in Response to Pregnancy-Related Deaths in California.

J Obstet Gynecol Neonatal Nurs 2019 Apr 11. Epub 2019 Apr 11.

Objective: To describe quality improvement opportunities (QIOs) associated with the five leading causes of pregnancy-related death in California and the methods by which the QIOs were collected by the California Pregnancy-Associated Mortality Review committee.

Design: Qualitative, descriptive design using thematic analysis.

Sample: A total of 907 QIOs identified from 203 cases of pregnancy-related deaths from cardiovascular disease, preeclampsia/eclampsia, hemorrhage, venous thromboembolism, and sepsis that occurred in California from 2002 to 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.03.003DOI Listing
April 2019
1 Read

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Preeclampsia/Eclampsia.

J Obstet Gynecol Neonatal Nurs 2019 Apr 10. Epub 2019 Apr 10.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from preeclampsia/eclampsia by the California Pregnancy-Associated Mortality Review Committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 242 QIOs identified from 54 cases of pregnancy-related deaths from preeclampsia/eclampsia in California between 2002 and 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.02.008DOI Listing
April 2019
1 Read

Opportunities for hospitals, hospital systems and leadership to improve VTE prophylaxis.

Semin Perinatol 2019 Mar 9. Epub 2019 Mar 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite F420, Houston, Texas.

A sustained increase in the maternal death rate in the U.S. remains one of the most challenging issues of the twenty-first century. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193003
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http://dx.doi.org/10.1053/j.semperi.2019.03.007DOI Listing
March 2019
2 Reads

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.

PLoS One 2019 12;14(4):e0215326. Epub 2019 Apr 12.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215326PLOS
April 2019
2 Reads

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.

Hypertens Pregnancy 2019 Apr 12:1-8. Epub 2019 Apr 12.

c Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Steele Center for Translational Medicine , University of Utah , Salt Lake City , USA.

Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD).

Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Read More

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http://dx.doi.org/10.1080/10641955.2019.1597107DOI Listing
April 2019
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Obstetrical and infant outcomes among women with neoplasms during pregnancy.

Cancer Causes Control 2019 Apr 11. Epub 2019 Apr 11.

Department of Epidemiology, University of Washington (UW), Seattle, WA, USA.

Purpose: One in 1,000 pregnancies is complicated by malignancies. Prevalence is greater for benign neoplasms. Adverse outcomes among women with malignancies have been reported. Read More

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http://link.springer.com/10.1007/s10552-019-01167-1
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http://dx.doi.org/10.1007/s10552-019-01167-1DOI Listing
April 2019
5 Reads

New Paradigm in the Role of Regulatory T Cells During Pregnancy.

Front Immunol 2019 26;10:573. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4CD25FoxP3 regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00573
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http://dx.doi.org/10.3389/fimmu.2019.00573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443934PMC
March 2019
3 Reads

A cohort study of the association between maternal serum Inhibin-A and adverse pregnancy outcomes: a population-based study.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):124. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: To compare the rates of adverse pregnancy outcomes between women with normal and abnormal inhibin-A levels.

Methods: Based on a prospective database of Down syndrome screening program, the consecutive records were comprehensively reviewed. Pregnancies were classified into three groups: normal, high (> 2 MoM) and low (< 0. Read More

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http://dx.doi.org/10.1186/s12884-019-2266-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458687PMC
April 2019
6 Reads

Hydroxychloroquine treatment during pregnancy in lupus patients is associated with lower risk of preeclampsia.

Lupus 2019 Apr 10:961203319843343. Epub 2019 Apr 10.

1 Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Hydroxychloroquine (HCQ) is regarded as a mainstay in the treatment of systemic lupus erythematosus (SLE) because of its efficacy in preventing flares, achieving remission, and reducing overall mortality. However, the impact of HCQ on pregnancy outcomes remains controversial.

Objective: We aimed to investigate the effect of HCQ on pregnancy outcomes in patients with SLE. Read More

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http://dx.doi.org/10.1177/0961203319843343DOI Listing
April 2019
4 Reads

The Elusive Role of Placental Macrophages: The Hofbauer Cell.

J Innate Immun 2019 Apr 10:1-10. Epub 2019 Apr 10.

Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa,

In this review, we discuss the often overlooked tissue-resident fetal macrophages, Hofbauer cells, which are found within the chorionic villi of the human placenta. Hofbauer cells have been shown to have a phenotype associated with regulatory and anti-inflammatory functions. They are thought to play a crucial role in the regulation of pregnancy and in the maintenance of a homeostatic environment that is crucial for fetal development. Read More

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http://dx.doi.org/10.1159/000497416DOI Listing
April 2019
1 Read

Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Braz J Med Biol Res 2019 Apr 8;52(4):e7546. Epub 2019 Apr 8.

Department of Gynecology and Obstetrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Read More

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http://dx.doi.org/10.1590/1414-431X20197546DOI Listing
April 2019
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In utero sFlt-1 exposure differentially affects gene expression patterns in fetal liver.

J Dev Orig Health Dis 2019 Apr 10:1-9. Epub 2019 Apr 10.

1Department of Obstetrics and Gynecology,University of Groningen,University Medical Center Groningen,The Netherlands.

The soluble fms-like tyrosine kinase factor 1 (sFlt-1) is a major contributor to antiangiogenesis during preeclampsia. However, little is known about the effects of sFlt-1 on fetal health. In this study we aim to evaluate the effects of the sFlt-1 concentration during pregnancy on fetal liver physiology. Read More

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http://dx.doi.org/10.1017/S2040174418000831DOI Listing
April 2019
2 Reads

Preeclampsia link to gestational hypoxia.

Authors:
W Tong D A Giussani

J Dev Orig Health Dis 2019 Apr 10:1-12. Epub 2019 Apr 10.

1Department of Physiology Development & Neuroscience,University of Cambridge,Cambridge,UK.

Complications of pregnancy remain key drivers of morbidity and mortality, affecting the health of both the mother and her offspring in the short and long term. There is lack of detailed understanding of the pathways involved in the pathology and pathogenesis of compromised pregnancy, as well as a shortfall of effective prognostic, diagnostic and treatment options. In many complications of pregnancy, such as in preeclampsia, there is an increase in uteroplacental vascular resistance. Read More

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http://dx.doi.org/10.1017/S204017441900014XDOI Listing
April 2019
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Delayed Initiation of Hemodialysis in Pregnant Women with Chronic Kidney Disease: Logistical Problems Impact Clinical Outcomes. An Experience from an Emerging Country.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Unidad de Investigación Médica en Enfermedades Nefrológicas, CMN Siglo XXI, 06720 CdMx, México.

Background: Chronic kidney disease (CKD) is associated with reduction of fertility and increased complications during pregnancy. The aim of this work is to analyze the clinical outcomes and risk factors in pregnant women who needed to start dialysis with different schedules in a public hospital in Mexico City, with particular attention on the interference of social and cultural elements as well as resource limitations.

Material And Methods: CKD women who needed dialysis in pregnancy over the period 2002⁻2014 and had with complete demographic and outcome data were included in this retrospective study. Read More

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http://dx.doi.org/10.3390/jcm8040475DOI Listing

Deep targeted sequencing reveals the diversity of TRB-CDR3 repertoire in patients with preeclampsia.

Hum Immunol 2019 Apr 6. Epub 2019 Apr 6.

Department of Genetics, National Research Institute for Family Planning, Beijing, 100081, China; Graduate School of Peking Union Medical College, Beijing, 100730, China. Electronic address:

Preeclampsia (PE) is one of the major causes of maternal and perinatal mortality worldwide. This study aimed to determine the immunological characteristics of PE patients and normal pregnancy at the T cell receptor beta-chain (TRB) level by using high-throughput sequencing. High-throughput sequencing was performed to analyze the expression of TRB-CDR3 in circulating T cells. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.04.003DOI Listing
April 2019
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The Inheritance of Cardiovascular Disease Risk.

Authors:
Mark Hanson

Acta Paediatr 2019 Apr 9. Epub 2019 Apr 9.

Institute of Developmental Sciences, University of Southampton and NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD, UK.

Cardiovascular disease (CVD) is foremost among the non-communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre-existing conditions still accounting for nearly 25% of maternal deaths, and is linked to gestational diabetes and preeclampsia. Markers of CVD risk have been reported even in young children, related to prenatal factors such as mother's diet or body composition. Read More

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http://dx.doi.org/10.1111/apa.14813DOI Listing
April 2019
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Omega-3 fatty acids differentially influences embryotoxicity in subtypes of preeclampsia.

Clin Exp Hypertens 2019 Apr 9:1-8. Epub 2019 Apr 9.

a Department of Mother and Child Health , Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University) , Pune , India.

Background: Early (EOP) and late onset (LOP) preeclampsia are two subtypes of preeclampsia. This study examines the effect of maternal omega-3 fatty acids and vitamin E supplementation in a rat model of preeclampsia.

Method: Pregnant Wistar rats were assigned to control; EOP; LOP; EOP+omega-3 fatty acid supplementation+vitamin E and LOP+omega-3 fatty acid supplementation+vitamin E. Read More

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http://dx.doi.org/10.1080/10641963.2019.1601208DOI Listing
April 2019
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Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy.

J Exp Med 2019 Apr 8. Epub 2019 Apr 8.

Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY.

Systemic lupus erythematosus carries an increased risk of pregnancy complications, including preeclampsia and fetal adverse outcomes. To identify the underlying molecular mechanisms, we longitudinally profiled the blood transcriptome of 92 lupus patients and 43 healthy women during pregnancy and postpartum and performed multicolor flow cytometry in a subset of them. We also profiled 25 healthy women undergoing assisted reproductive technology to monitor transcriptional changes around embryo implantation. Read More

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http://dx.doi.org/10.1084/jem.20190185DOI Listing
April 2019
6 Reads
12.515 Impact Factor

The association between high-normal blood pressure and the development of preeclampsia in twin pregnancies.

J Matern Fetal Neonatal Med 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Department of Obstetrics , Gynecology, and Reproductive Sciences, Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Objective: We sought to determine if women with twin pregnancies and blood pressure (BP) above the 95th percentile but within normal ranges (i.e. less than 140 systolic and 90 diastolic) are at increased risk of hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601696DOI Listing
April 2019
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[FUNCTIONAL STATUS OF THE VISUAL ORGAN DURING PREECLAMPSIA].

Georgian Med News 2019 Feb(287):39-44

Sumy State University, Medical Institute, Sumy State University, Department of Surgery and Oncology; Department of Obstetrics anf Gynecology; Academic and Research Institute of Law, Department of Administrative, Economic Law and Economic Security, Ukraine.

The purpose of this research is to study the effect of preeclampsia of pregnant women on the functional status of the visual organ. The research study was made on 77 pregnant women (154 eyes) from 17 to 43 years old. Based on the analysis of the research results, during uncomplicated pregnancy and mild preeclampsia we found no significant changes in the foveolar retinal thickness and macular retinal volume both during various trimesters of pregnancy and postpartum. Read More

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February 2019
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The risk of adverse obstetric outcomes and the abnormal growth of offspring in women with a history of thyroid cancer.

Thyroid 2019 Apr 8. Epub 2019 Apr 8.

Northwestern University, Obstetrics and Gynecology , 303 E. Superior Street , Chicago, Illinois, United States , 60611 ;

Background: It is unclear whether a history of thyroid cancer is associated with an increased risk of adverse pregnancy outcomes in subsequent pregnancies. This study aimed to evaluate the risk of adverse obstetric outcomes and the abnormal growth of offspring in women with a history of thyroid cancer.

Methods: In this retrospective observational study, we used nationwide data between 2006 and 2014 to compare pregnancy outcomes between women with a history of thyroid cancer and those with no such history. Read More

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http://dx.doi.org/10.1089/thy.2018.0283DOI Listing
April 2019
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Evaluation of Placental VEGFA mRNA Expression in Preeclampsia: A Case Control Study.

J Obstet Gynaecol India 2019 Apr 12;69(2):142-148. Epub 2018 May 12.

1Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur, Delhi, 110095 India.

Objective: The aim of our case-control study was to determine expression of VEGFA mRNA in placentae of preeclamsia (PE) versus uncomplicated pregnancy to further clarify its differential expression in pregnancy hypertensive disorders.

Study Design: The PE group was subdivided into severe and non-severe; those with or without HELLP syndrome and placental VEGFA characteristics were compared for these cohorts. Additionally, the neonatal and maternal outcomes were recorded. Read More

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http://dx.doi.org/10.1007/s13224-018-1128-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430265PMC
April 2019
3 Reads

Impact of Unintended Pregnancy on Maternal and Neonatal Outcomes.

J Obstet Gynaecol India 2019 Apr 16;69(2):136-141. Epub 2018 May 16.

1Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Bani Hashem Place, Hafez St., P.O. Box: 16635148, Tehran, Iran.

Background: Pregnancy outcomes might be affected by unintended pregnancy such as preeclampsia, preterm birth, cesarean section and low birth weight. The aim of the present study is to assess the association between unintended pregnancy and pregnancy outcomes.

Methods: This was a cross-sectional study conducted in 103 hospitals in Tehran, Iran, in July 2015. Read More

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http://link.springer.com/10.1007/s13224-018-1125-5
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http://dx.doi.org/10.1007/s13224-018-1125-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430264PMC
April 2019
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Plasma concentrations of soluble endoglin in the maternal circulation are associated with maternal vascular malperfusion lesions in the placenta of women with preeclampsia.

Placenta 2019 Mar 1;78:29-35. Epub 2019 Mar 1.

Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

We evaluated the association between plasma soluble endoglin (sENG) and maternal vascular malperfusion (MVM) lesions of the placenta in women with preeclampsia. We measured sENG (sCD105) by ELISA in N = 70 women diagnosed with preeclampsia (median [IQR] GA at sampling = 36.4 [6. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455971PMC
March 2019
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Role of proteases in dysfunctional placental vascular remodelling in preeclampsia.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 5. Epub 2019 Apr 5.

Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, 4029, Queensland, Australia; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile. Electronic address:

Preeclampsia is a syndrome characterised by vascular dysfunction, impaired angiogenesis, and hypertension during pregnancy. Even when the precise pathophysiology of preeclampsia remains elusive, impaired vascular remodelling and placental angiogenesis in the placental villi and defective trophoblast invasion of the uterus are proposed as crucial mechanisms in this syndrome. Reduced trophoblast invasion leads to reduced uteroplacental blood flow and oxygen availability and increased oxidative stress. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.04.004DOI Listing
April 2019
3 Reads