38,465 results match your criteria Pregnancy Preeclampsia


Influence of NKG2C gene deletion and CCR5Δ32 in Pre-eclampsia-Approaching the effect of innate immune gene variants in pregnancy.

Int J Immunogenet 2019 Feb 20. Epub 2019 Feb 20.

Laboratório de Imunobiologia e Imunogenética, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brazil.

Pre-eclampsia (PE) is a hypertensive disorder that affects an important number of pregnant women worldwide. The exact causes of PE remain poorly understood. However, inflammation and deregulation of innate immune cells, such as natural killer (NK) cells, contribute to PE pathogenesis. Read More

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http://dx.doi.org/10.1111/iji.12416DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study.

PLoS One 2019 20;14(2):e0211857. Epub 2019 Feb 20.

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Background: Peripartum cardiomyopathy (PPCM) is a serious cardiac disorder occurring late in pregnancy or early in the postpartum period. We examined associations between hypertensive disorders of pregnancy (HDP: preeclampsia and gestational hypertension) and PPCM, accounting for other pregnancy-related risk factors for PPCM.

Methods: Using nationwide Danish register data, we constructed a cohort of all women with ≥1 live birth or stillbirth in Denmark between 1978 and 2012. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211857PLOS
February 2019

Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester.

Scand J Clin Lab Invest 2019 Feb 20:1-8. Epub 2019 Feb 20.

i Kantonsspital Graubünden , Zentrallabor , Chur , Switzerland.

Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized markers of endothelial dysfunction. Read More

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http://dx.doi.org/10.1080/00365513.2019.1568150DOI Listing
February 2019

Influence of forkhead box protein 3 polymorphisms (rs2232365, rs3761548) with the outcome of pregnancy: A meta-analysis.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Dysfunction of regulatory T cells (Tregs) may contribute to certain immune-related pregnancy complications. Forkhead box protein 3 (FOXP3) is the key transcription factor of Treg. We performed a systematic review and meta-analysis to evaluate the possible association between FOXP3 polymorphisms -924A/G (rs2232365) and -3279C/A (rs3761548) and immune-related pregnancy complications. Read More

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http://dx.doi.org/10.1002/jcp.28328DOI Listing
February 2019

Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Earlyand Late-Onset Preeclampsia.

Bull Exp Biol Med 2019 Feb 19. Epub 2019 Feb 19.

V. I. Kulakov National Research Medical Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental tissue (hematoxylin and eosin staining) and immunohistochemical analysis with primary monoclonal antibodies to TLR4 and Tollip were performed on serial paraffin sections. It was found that the expression of TLR4 increased with increasing gestation term in both the syncytiotrophoblast and vascular endothelium of the placental villi (p<0. Read More

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http://dx.doi.org/10.1007/s10517-019-04383-6DOI Listing
February 2019

The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort.

BMC Pregnancy Childbirth 2019 Feb 19;19(1):75. Epub 2019 Feb 19.

The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: Homocysteine is an intermediate metabolite implicated in the risk of placenta-mediated complications, including preeclampsia, placental abruption, fetal growth restriction, and pregnancy loss. Large cohort and case-control studies have reported inconsistent associations between homocysteine and these complications. The purpose of this study was to investigate whether elevated maternal plasma homocysteine concentration in the early to mid-second trimester is associated with an increased risk of placenta-mediated complications. Read More

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http://dx.doi.org/10.1186/s12884-019-2219-5DOI Listing
February 2019

Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".

Medicina (Kaunas) 2019 Feb 18;55(2). Epub 2019 Feb 18.

Institute of Histology and Embryology, Faculty of Medicine, Comenius University in Bratislava, 813 72 Bratislava, Slovakia.

In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes. Read More

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http://dx.doi.org/10.3390/medicina55020056DOI Listing
February 2019

TNF-alpha inhibits pregnancy-adapted Ca signaling in uterine artery endothelial cells.

Mol Cell Endocrinol 2019 Feb 16. Epub 2019 Feb 16.

Perinatal Research Laboratories, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin-Madison, 7E Unity Point Health-Meriter Hospital, 202 South Park Street, Madison, WI, 53715, USA. Electronic address:

Enhancement of vasodilation of uterine arteries during pregnancy occurs through increased connexin (Cx)43 gap junction (GJ) communication supporting more frequent and sustained Ca 'bursts'. Such adaptation is lacking in subjects with preeclampsia (PE). Here we show TNF-alpha, commonly increased in PE subjects, inhibits Cx43 function and Ca bursts in pregnancy-derived ovine uterine artery endothelial cells (P-UAEC) via Src and MEK/ERK phosphorylation of Cx43, and this can be reversed by PP2 or U0126. Read More

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http://dx.doi.org/10.1016/j.mce.2019.02.008DOI Listing
February 2019

Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications.

Circulation 2019 Feb;139(8):1069-1079

Department of Epidemiology, Biostatisticcs and Occupational Health, McGill University, Montreal, QC, Canada (S.G., K.F., S.Y., H.A., C.D., R.P.).

Background: Women with a history of certain pregnancy complications are at higher risk for cardiovascular (CVD) disease. However, most clinical guidelines only recommend postpartum follow-up of those with a history of preeclampsia, gestational diabetes mellitus, or preterm birth. This systematic review was undertaken to determine if there is an association between a broader array of pregnancy complications and the future risk of CVD. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036748DOI Listing
February 2019

Pregnancy After Renal Transplant: Single Center Experience From the Middle East in Patients Using Different Calcineurin Inhibitors.

Exp Clin Transplant 2019 Jan;17(Suppl 1):99-104

From the Nephrology Department, Hamed Al-Essa Organ Transplant Center, Sabah Area, Kuwait.

Objectives: Pregnancy after kidney transplant has a high risk for maternal and fetal complications; however, it can be successful if patients are properly selected. Here, we studied outcomes and complications of pregnancies in kidney transplant recipients who received calcineurin inhibitor-based immunosuppression.

Materials And Methods: In this case control study, we reviewed patients who became pregnant between 2004 and 2017. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O42DOI Listing
January 2019

The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

Lupus 2019 Feb 18:961203319829825. Epub 2019 Feb 18.

2 Department of Rheumatology, State University of Rio de Janeiro, Brazil.

Objective: To analyze the impact of different classes of lupus nephritis as risk variables for maternal and fetal adverse outcomes in a cohort of pregnant lupus patients.

Methods: This is a cohort study with retrospective and prospective data collection, conducted at the University Hospital of State University of Rio de Janeiro, Brazil, from 2011 to 2016. A total of 147 pregnancies of 137 systemic lupus erythematosus patients of whom 66 had lupus nephritis were included. Read More

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http://dx.doi.org/10.1177/0961203319829825DOI Listing
February 2019

Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.

FASEB J 2019 Feb 18:fj201802058RR. Epub 2019 Feb 18.

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China.

Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast cells. Abnormal functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset preeclampsia. Read More

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http://dx.doi.org/10.1096/fj.201802058RRDOI Listing
February 2019

Obstructive sleep apnoea in multiple pregnancy.

Aust N Z J Obstet Gynaecol 2019 Feb 17. Epub 2019 Feb 17.

Department of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Obstructive sleep apnoea (OSA) during pregnancy has been associated with gestational diabetes mellitus, hypertension and low birth weight. Multiple pregnancy is associated with similar adverse perinatal outcomes. Multiple pregnancy rates have risen with increased access to assisted conception; simultaneously, advancing maternal age and weight are also driving a rise in the incidence of OSA in pregnancy. Read More

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http://dx.doi.org/10.1111/ajo.12958DOI Listing
February 2019

A retrospective study on evaluation of anti-hypertensive drugs used in gestational hypertension.

Pak J Pharm Sci 2019 Jan;32(1):213-215

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Read More

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January 2019
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The European registry on obstetric Antiphospholipid syndrome (EUROAPS): A survey of 1000 consecutive cases.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.

Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS).

Methods: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.006DOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019
2 Reads

Maternal preeclampsia and respiratory outcomes in extremely premature infants.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive. The objective of this study was to determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0336-5DOI Listing
February 2019
2 Reads

A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks.

J Clin Endocrinol Metab 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynaecology, NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Context: Previous studies have shown reduced placental levels of 11-beta-hydroxysteroid dehydrogenase-type 2 (11βHSD2) in preeclampsia. However, it is not known if the maternal cortisol to cortisone ratio is predictive of placental complications of pregnancy.

Objective: To determine the relationship between the maternal serum cortisol to cortisone ratio at different stages of pregnancy and the risk of preeclampsia or fetal growth restriction (FGR). Read More

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http://dx.doi.org/10.1210/jc.2018-02312DOI Listing
February 2019
1 Read

How can we make pregnancy safe for women with Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 Feb 15. Epub 2019 Feb 15.

Endocrinology Department, Saint Antoine Hospital, Centre de Référence des Maladies Endocrines Rares de la Croissance, Filière FIRENDO, ENDO-ERN, Paris, France.

Pregnancy is a crucial issue in patients with Turner syndrome (TS). Although natural pregnancies have been reported in 4-7% of TS patients, most women will need assisted reproductive technologies (ART) with oocyte donation. The main issue is the maternal mortality rate that is higher than in the general population. Read More

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http://dx.doi.org/10.1002/ajmg.c.31682DOI Listing
February 2019
1 Read

Placental location and pregnancy outcomes in nulliparous women: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.

Introduction: The impact of placenta previa on pregnancy, delivery and infant outcomes has been extensively studied. Less is however known about the possible association of placental location other than previa with pregnancy outcomes. The aim of this study was to investigate if placental location other than previa is associated with adverse pregnancy, delivery and infant outcomes. Read More

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http://dx.doi.org/10.1111/aogs.13578DOI Listing
February 2019
1 Read

Pregnancy Outcomes in Women with Strictly Controlled Type 1 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):798-800

Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.

Objective: To evaluate the pregnancy outcomes in mothers with controlled Type 1 diabetes mellitus (T1DM).

Materials And Methods: Thirty seven pregnant patients with controlled T1DM were included in the study.

Results: Twenty (54%) out of 37 patients had preterm delivery (<37 weeks of gestation). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330866PMC
February 2019

Rosiglitazone blocks first trimester in-vitro placental injury caused by NF-κB-mediated inflammation.

Sci Rep 2019 Feb 14;9(1):2018. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.

Increased inflammation and abnormal placentation are common features of a wide spectrum of pregnancy-related disorders such as intra uterine growth restriction, preeclampsia and preterm birth. The inflammatory response of the human placenta has been mostly investigated in relation to cytokine release, but the direct molecular consequences on trophoblast differentiation have not been investigated. This study measured the general effects of LPS on both extravillous and villous trophoblast physiology, and the involvement of the transcription factors PPARγ and NF-κB, specifically using 1 trimester explants and HTR-8/ SVneo cell line models. Read More

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http://dx.doi.org/10.1038/s41598-018-38336-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376060PMC
February 2019

The placenta: A site of end-organ damage after Fontan operation. A case series.

Int J Cardiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL, United States of America.

Background: Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology.

Methods: We reviewed clinical charts and placental pathology from 7 women with Fontan physiology who had pregnancies at Mayo Clinic, Rochester, Minnesota. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.002DOI Listing
February 2019
1 Read

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.

J Am Heart Assoc 2019 Feb;8(4):e010647

1 Division of Nephrology & Hypertension Mayo Clinic Rochester MN.

Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial dysfunction and activation. Methods and Results We examined the sublingual glycocalyx noninvasively using sidestream dark field imaging in the third trimester among women with normotensive pregnancies (n=73), early (n=14) or late (n=29) onset preeclampsia, or gestational diabetes mellitus (n=21). Read More

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http://dx.doi.org/10.1161/JAHA.118.010647DOI Listing
February 2019
1 Read

The ability of thromboelastography parameters to predict severe pre-eclampsia when measured during early pregnancy.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: To examine the predictive value of thromboelastography parameters during early pregnancy as potential markers of severe pre-eclampsia during late pregnancy.

Methods: An observational retrospective case-control study was conducted among pregnant women who attended a single hospital in Shanghai, China, between July 1, 2016, and February 31, 2018. Data were obtained from medical records and a structured questionnaire completed by the participants. Read More

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http://dx.doi.org/10.1002/ijgo.12785DOI Listing
February 2019
1 Read

Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study.

J Matern Fetal Neonatal Med 2019 Feb 13:1-171. Epub 2019 Feb 13.

a Obstetrics and Gynecology Department , Graduate Entry Medical School , University of Limerick , Limerick , Ireland.

Introduction: Individual placental and umbilical cord morphometry have been previously identified to have an association with fetal growth. This study aims to identify which of the morphometric measurements in combination are associated with pregnancies with small for gestational age (SGA) infants using digital imaging of the delivered placenta.

Material And Methods: This study examined 1005 placentas from consecutively delivered singleton pregnancies in a tertiary center. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582628DOI Listing
February 2019
1 Read

Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.

Hypertens Pregnancy 2019 Feb 13;38(1):58-63. Epub 2019 Feb 13.

a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil.

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.

Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.

Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. Read More

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http://dx.doi.org/10.1080/10641955.2019.1577435DOI Listing
February 2019
1 Read

Third trimester uterine artery Doppler indices as predictors of preeclampsia and neonatal small for gestational age.

J Matern Fetal Neonatal Med 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Obstetrics and Gynecology , University of South Florida Morsani College of Medicine , Tampa , FL , USA.

Objective: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population.

Study Design: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1575804DOI Listing
February 2019
1 Read

Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, PA.

Background: Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of mid-pregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in mid-pregnancy identify not only a subset of women at risk for pregnancy complications, but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036632DOI Listing
February 2019
1 Read

"Not taken seriously"-A qualitative interview study of postpartum Rwandan women who have experienced pregnancy-related complications.

PLoS One 2019 13;14(2):e0212001. Epub 2019 Feb 13.

Department of Clinical Sciences, Obstetrics and Gynaecology, Umeå University, Umeå, Sweden.

Background: There is limited knowledge on the women's experiences of pregnancy-related complications in Rwanda. This study aimed to investigate women's experiences and perceptions of specific complications during pregnancy and delivery and the consequences of these complications on postpartum health and family situation.

Methods: Data were collected through individual in-depth interviews (N = 15). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212001PLOS
February 2019
1 Read

Predictive value of soluble fms-like tyrosine kinase-1 against placental growth factor for preeclampsia in a Chinese pregnant women population.

J Clin Lab Anal 2019 Feb 13:e22861. Epub 2019 Feb 13.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: The purpose of the present study was to explore the predictive effects of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) for preeclampsia.

Methods: A total of 1580 singleton pregnant women aged 18-45 years were included in this study. Serum samples were collected and stored frozen during their regular obstetric examinations. Read More

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http://doi.wiley.com/10.1002/jcla.22861
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http://dx.doi.org/10.1002/jcla.22861DOI Listing
February 2019
5 Reads

Is there a future for cell-free fetal dna tests in screening for preeclampsia?

Ginekol Pol 2019 ;90(1):55-60

First Department of Obstetrics and Gynaecology, Medical University of Warsaw, Poland.

CffDNA screening is a powerful diagnostic tool in the prenatal diagnosis algorithm for chromosomal abnormalities. With detailed ultrasound examination as the mainstay of first-trimester risk assessment, cffDNA has been shown to be superior to first-trimester combined screening (FTCS) in false-positive rates for trisomy 21 detection. In light of the growing interest in cffDNA testing and the possibility of it replacing first-trimester biochemistry, we decided to investigate the usefulness of cffDNA tests in early-pregnancy risk assessment for preeclampsia (PE). Read More

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http://dx.doi.org/10.5603/GP.2019.0009DOI Listing
January 2019
2 Reads

The health of children conceived by ART: 'the chicken or the egg?'

Hum Reprod Update 2019 Feb 12. Epub 2019 Feb 12.

Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark.

Worldwide, more than 7 million children have now been born after ART: these delivery rates are steadily rising and now comprise 2-6% of births in the European countries. To achieve higher pregnancy rates, the transfer of two or more embryos was previously the gold standard in ART. However, recently the practise has moved towards a single embryo transfer policy to avoid multiple births. Read More

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http://dx.doi.org/10.1093/humupd/dmz001DOI Listing
February 2019
3 Reads

Lvrn expression is not critical for mouse placentation.

J Reprod Dev 2019 Feb 10. Epub 2019 Feb 10.

Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

Preeclampsia is a systemic disease caused by abnormal placentation that affects both mother and fetus. It was reported that Laeverin (LVRN, also known as Aminopeptidase Q) was up-regulated in the placenta of preeclamptic patients. However, physiological and pathological functions of LVRN remained to be unknown. Read More

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https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_201
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http://dx.doi.org/10.1262/jrd.2018-157DOI Listing
February 2019
7 Reads

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.002DOI Listing
February 2019
1 Read

Causes and contributory factors of maternal mortality: evidence from maternal and perinatal death surveillance and response in Ogun state, Southwest Nigeria.

BMC Pregnancy Childbirth 2019 Feb 11;19(1):63. Epub 2019 Feb 11.

Ogun State Primary Health Care Board, Abeokuta, Nigeria.

Background: Nigeria still ranks second globally in the number of maternal deaths. Most maternal death reviews in Nigeria are isolated research based reports from a single health facility. This study determined causes and contributory factors of maternal mortality in Ogun statefollowing a periodic State-widematernal and perinatal deaths surveillance and response (MPDSR) review. Read More

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http://dx.doi.org/10.1186/s12884-019-2202-1DOI Listing
February 2019
2 Reads

T lymphocytes in the third trimester decidua in preeclampsia.

Hypertens Pregnancy 2019 Feb 11;38(1):52-57. Epub 2019 Feb 11.

c Department of Pathology, Faculty of Medicine , University of Nis , Nis , Serbia.

Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia.

Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. Read More

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http://dx.doi.org/10.1080/10641955.2019.1575393DOI Listing
February 2019
1 Read

Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

New Haven CT, Yale School of Medicine.

Background: Cardiovascular disease (CVD) is the leading cause of pregnancy-related death in the United States. (1) Identification of short-term indicators of cardiovascular morbidity has the potential to alter the course of this devastating disease among women. It has been established that hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease 10-30 years after delivery; however, little is known about the association of hypertensive disorders of pregnancy with cardiovascular (CV) morbidity during the delivery hospitalization. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.010DOI Listing
February 2019
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Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 Feb;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114435DOI Listing
February 2019
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Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.

Biochem Biophys Res Commun 2019 Mar 7;510(4):587-593. Epub 2019 Feb 7.

Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai, 980-8578, Japan; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. Electronic address:

Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.110DOI Listing
March 2019
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High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia.

Redox Biol 2019 Jan 26;22:101126. Epub 2019 Jan 26.

Inserm U-1048, Université de Toulouse, France. Electronic address:

Decreased nitric oxide (NO) bioavailability plays a critical role in the pathophysiology of preeclampsia (PE). Recent evidence indicates that S-glutathionylation may occur on the endothelial nitric oxide synthase (eNOS), leading to eNOS uncoupling, characterized by a decreased NO production and an increased generation of superoxide anion (O). We hypothesized that eNOS glutathionylation may occur in PE placentas and participate in eNOS dysfunction. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101126DOI Listing
January 2019
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Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries.

Am J Obstet Gynecol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy.

We explore the potential role of the endothelial lining of uteroplacental arteries in the pathogenesis of preeclampsia, a severe pregnancy disorder characterized by incomplete invasion of the uterine vasculature by extravillous trophoblast and angiogenic imbalance. In normal pregnancy, the endothelium disappears progressively from the uteroplacental arteries and is replaced by trophoblast and deposition of fibro-fibrinoid structure, underpinning the so-called physiological transformation of uterine spiral arteries. We hypothesize that partial persistence of the endothelium, albeit injured, initiates a chain of events leading to the emergence of preeclampsia in three sequential stages. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.239DOI Listing
February 2019
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Role of uterine blood flow disturbances in the development of late gestosis.

Wiad Lek 2018 ;71(9):1719-1721

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: Chronic endometritis (CE) associated lesions lessen the implantation potential of endometrium and aggravate the course of invasive processes in the uterine vessels The aim: Study of changes in doplerometric parameters of blood flow in spiral and uterine arteries in 17-18 weeks of pregnancy in women with СE in anamnesis.

Patients And Methods: Materials and methods: Сalculation of systolic/diastolic ratio (SDR), pulse index (PI) and resistive index (RI) has been carried out in 70 pregnant had CE in past history and 10 healthy pregnant women who experienced neither chronic endometritis before pregnancy nor preeclampsia.

Results: Results: SDR in SA patients with CE in history and follow-up development of preeclampsia is by 19& higher the control values (р<0,05); PI was 85& higher than the similar one in the control group and RI was 86& higher (р<0,01). Read More

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January 2018
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Trial of labor after cesarean section in risk pregnancies: a population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n=57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
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The immunophenotype of decidual macrophages in acute atherosis.

Am J Reprod Immunol 2019 Feb 8:e13098. Epub 2019 Feb 8.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U. S. Department of Health and Human Services Bethesda, Maryland, and Detroit, Michigan, USA.

Problem: Acute atherosis is a uteroplacental arterial lesion that is associated with pregnancy complications such as preeclampsia and preterm birth, the leading cause of perinatal morbidity and mortality worldwide. However, the immunobiology of acute atherosis is poorly understood.

Method Of Study: Placental basal plate samples were collected from women who delivered with (n = 11) and without (n = 31) decidua basalis lesions of acute atherosis. Read More

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http://doi.wiley.com/10.1111/aji.13098
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http://dx.doi.org/10.1111/aji.13098DOI Listing
February 2019
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Preeclamptic serous retinal detachment without hypertension: A case report.

Case Rep Womens Health 2019 Jan 23;21:e00098. Epub 2019 Jan 23.

Department of Obstetrics & Gynecology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23704, United States.

Preeclampsia is a disease of pregnancy classically defined by the development of new-onset hypertension and proteinuria. Serous retinal detachment is a rare complication of severe preeclampsia that is associated with a high incidence of morbidity and mortality. We present the case of a 24-year-old primigravida who was diagnosed with preeclamptic serous retinal detachment at 30 weeks of gestation that occurred in the absence of hypertension. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358546PMC
January 2019
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Cerebral pontine infarctions during pregnancy - A case report and review of the literature.

Case Rep Womens Health 2019 Jan 23;21:e00097. Epub 2019 Jan 23.

University of South Alabama, Children's and Women's Hospital, Department of Obstetrics and Gynecology, 251 Cox Street, Mobile, AL 36604, United States.

Cerebrovascular disease is not uncommon during pregnancy as a result of either venous or arterial occlusion, or a hemorrhagic event, resulting in ischemia. Pregnancy may alter the prognosis of these neurologic disorders, with increased risks of morbidity and mortality for the mother and the developing fetus. Etiologies of stroke during pregnancy and the postpartum period include preeclampsia, eclampsia, HELLP syndrome, posterior reversible encephalopathy syndrome (PRES), amniotic fluid embolism, postpartum angiopathy, postpartum cardiomyopathy, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), cerebral venous thrombosis, CNS infections, and maternal thrombophilia. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358547PMC
January 2019
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Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia.

Sci Rep 2019 Feb 7;9(1):1550. Epub 2019 Feb 7.

Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Preeclampsia is one of the most serious complications during pregnancy, defined as development of hypertension during late pregnancy affecting other organ systems (proteinuria, thrombocytopenia, renal insufficiency, liver involvement, cerebral symptoms or pulmonary edema). Preeclampsia is known to be associated with significant dyslipidemia, but the cause or mechanism of this metabolic aberration is not clear. Quantitative analysis of cholesterol precursors and metabolites can reveal metabolic signatures of cholesterol, and provide insight into cholesterol biosynthetic and degradation pathways. Read More

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http://dx.doi.org/10.1038/s41598-018-37757-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367404PMC
February 2019
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Successful rescue of antepartum eclampsia in a Chinese patient: Case report.

Medicine (Baltimore) 2019 Feb;98(6):e14301

Central Laboratory of Medicine, Maternity and Child Health Hospital of Zhenjiang, Zhenjiang, Jiangsu, P.R. China.

Rationale: Eclampsia is a life-threatening complication of pregnancy. Eclampsia is a leading cause of maternal and neonatal morbidity and mortality with most injury being associated with the seizures that mark the onset of the disease. It is vital that medical worker managing eclampsia have an understanding of the disease process. Read More

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http://dx.doi.org/10.1097/MD.0000000000014301DOI Listing
February 2019
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