43,651 results match your criteria Pregnancy Preeclampsia


microRNA-210/ Long non-coding RNA MEG3 axis inhibits trophoblast cell migration and invasion by suppressing EMT process.

Placenta 2021 May 5;109:64-71. Epub 2021 May 5.

Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Introduction: Pre-eclampsia is characterized by insufficient spiral artery remodeling, and trophoblast dysfunction plays an important role in this process. Noncoding RNAs (microRNAs (miRNAs) and long noncoding RNAs (LncRNAs) are included) can regulate trophoblasts. MicroRNA-210 (miR-210) can decrease trophoblast cell migration and invasion and may act as a biomarker for preeclampsia. Read More

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Early ADAMTS13 testing associates with pre-eclampsia occurrence in antiphospholipid syndrome.

Thromb Res 2021 Apr 27;203:101-109. Epub 2021 Apr 27.

Department of Gynaecology and Obstetrics, First Moscow State Medical University (Sechenov University), Russian Federation; Department of Haematology, CHU Nîmes, Univ Montpellier, Nîmes, France; Faculty of Pharmaceutical and Biological Sciences, Montpellier University, Montpellier, France; UA 011 INSERM- Université de Montpellier, Institut Desbrest d'Epidémiologie et de Santé Publique, Montpellier, France. Electronic address:

Introduction: Women with obstetric antiphospholipid syndrome (oAPS) still develop placental diseases, mainly pre-eclampsia (PEcl), which diagnosis is associated with reduced ADAMTS13 levels. Testing ADAMTS13 in newly pregnant oAPS may provide evidence for risk stratification.

Materials And Methods: We retrospectively investigated the prognostic value of ADAMTS13 activity, antigen and antibodies on stored plasma samples obtained prior to beginning low-molecular weight heparin-low dose aspirin treatment in 513 oAPS women. Read More

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The effects of infection on pregnancy-related diseases and fetal development in diabetes in pregnancy.

Ann Transl Med 2021 Apr;9(8):686

Endocrinology Department, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: This study aimed to determine the association of () infection with pregnancy-related diseases and fetal development in women with diabetes in pregnancy (DIP).

Methods: All the participants were recruited before 16 weeks of gestation. According to their medical history and the results of a 75-g oral glucose tolerance test at the 24 week of pregnancy, the participants were divided into a normal control group (NC group), a gestational diabetes mellitus group (GDM group), and a pre-pregnancy diabetes mellitus group (PGDM group). Read More

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Paradigms for investigating invasive trophoblast cell development and contributions to uterine spiral artery remodeling.

Placenta 2021 May 3. Epub 2021 May 3.

Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS 66160, USA; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA; Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160, USA; Center for Perinatal Research, Children's Mercy Research Institute, Children's Mercy Kansas City, Missouri 64108, USA. Electronic address:

Uterine spiral arteries are extensively remodeled during placentation to ensure sufficient delivery of maternal blood to the developing fetus. Uterine spiral arterial remodeling is complex, as cells originating from both mother and developing conceptus interact at the maternal interface to regulate the extracellular matrix remodeling and vasculature restructuring necessary for successful placentation. Despite this complexity, one mechanism critical to spiral artery remodeling is trophoblast cell invasion into the maternal compartment. Read More

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Ultrasound evaluation of the placenta in healthy and placental syndrome pregnancies: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2021 May 4;262:45-56. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Maastricht University Medical Centre (MUMC+), the Netherlands.

Introduction: An antepartum screening method to determine normal and abnormal placental function is desirable in the prevention of maternal and fetal pregnancy complications. Placental appearance can easily be obtained and evaluated using 2D ultrasonography, but surprisingly little is known about the change in placental appearance during gestation. Aim of this systematic review was to describe the antepartum placental appearance in placenta syndrome (PS) pregnancies, and to compare this to the appearance in healthy pregnancies. Read More

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Maternal and Fetal Outcomes of Urolithiasis: A Retrospective Cohort Study.

J Gynecol Obstet Hum Reprod 2021 May 10:102161. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Center for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada. Electronic address:

Objectives: Although urolithiasis is relatively common in the general population, there is limited information on this condition available in the pregnant population. The objectives of this study are to identify the incidence of urolithiasis in pregnancy, as well as to compare maternal and fetal outcomes associated with urolithiasis in pregnancy.

Methods: Using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample database from the United States, a population-based retrospective cohort study consisting of pregnant women who delivered between 1999 and 2015 was conducted. Read More

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Residential proximity to tree canopy and preterm birth in black women.

Am J Obstet Gynecol MFM 2021 May 10:100391. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI; Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Objective: There are significant racial disparities in obstetric outcomes with the incidence of preterm birth (PTB) being the highest in non-Hispanic black women. The presence of green space, such as forests and parks, is now widely viewed as a health-promoting characteristic of residential environments. The objective of this study was to examine the association between proximity of tree canopy to a prenatal residential address and the rates of PTB in non-Hispanic black women in Milwaukee, WI. Read More

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Pregnancy outcomes in women with booking HbA1c ≤ 40 mmol/mol compared with 41-49 mmol/mol in South Auckland, New Zealand.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Counties Manukau Health, Auckland, New Zealand.

Aims: There are few data on pregnancy outcomes in women with pre-diabetes (HbA1c 41-49 mmol/mmol) at pregnancy booking. We aimed to (i) identify the proportion of women in Counties Manukau Health (CMH), South Auckland, New Zealand (NZ), with pre-diabetes at booking and (ii) compare outcomes between women with normal HbA1c and pre-diabetes.

Materials And Methods: Using data from a multi-ethnic population of 10,869 singleton pregnancies, booked at <20 weeks from January 2017 to December 2018 in CMH, we compared outcomes between those with normal HbA1c (≤40 mmol/mol) and those with pre-diabetes (HbA1c 41-49 mmol/mol). Read More

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Combined Oral Contraceptive Pill-Induced Hypertension and Hypertensive Disorders of Pregnancy: Shared Mechanisms and Clinical Similarities.

Curr Hypertens Rep 2021 May 13;23(5):29. Epub 2021 May 13.

Division of Nephrology and Hypertension, Department of Internal Medicine, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN, USA.

Purpose Of Review: Oral contraceptive pill-induced hypertension (OCPIH) and hypertensive disorders in pregnancy (HDP) share common risk factors and pathophysiological mechanisms, yet the bidirectional relationship between these two conditions is not well-established. We review and describe OCPIH and HDP to better understand how hormonal and metabolic imbalances affect hypertension.

Recent Findings: Oral contraceptive pills continue to be a popular method of contraception, with an incidence of OCPIH ranging from 1-8. Read More

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Maternal Hypertensive Pregnancy Disorders and Mental and Behavioral Disorders in the Offspring: a Review.

Curr Hypertens Rep 2021 May 13;23(5):30. Epub 2021 May 13.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 9, FI-00014 University of Helsinki, Helsinki, Finland.

Purpose Of Review: We review here recent original research and meta-analytic evidence on the associations of maternal hypertensive pregnancy disorders and mental and behavioral disorders in the offspring.

Recent Findings: Seven meta-analyses and 11 of 16 original research studies published since 2015 showed significant associations between maternal hypertensive pregnancy disorders and offspring mental and behavioral disorders. Evidence was most consistent in meta-analyses and high-quality cohort studies. Read More

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Value of second-trimester uterine artery pulsatility index in pregnancies with systemic lupus erythematosus and/or antiphospholipid syndrome.

J Matern Fetal Neonatal Med 2021 May 12:1-7. Epub 2021 May 12.

Department of Obstetrics and Gynecology, Hospital General de Granollers, Barcelona, Spain.

Objective: To assess the value of the second trimester mean pulsatility index of the uterine arteries (MPI-UtA) to predict adverse perinatal outcome (APO) in women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS).

Methods: Pregnancies with either an SLE diagnosis or with primary APS controlled at our Hospital during a 10 years period were included. MPI-UtA was performed between 19-23 weeks' gestation. Read More

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Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia.

Hypertens Pregnancy 2021 May 12:1-9. Epub 2021 May 12.

Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

The aim of this study was to explore the expression and effects of tumor necrosis factor alpha (TNFα) in maternal endothelial cells in preeclampsia (PE). Expression levels in primary microvascular endothelial cells (MVEC) isolated from patients with severe preeclampsia (PE) and normal pregnancies were determined by RT-qPCR with or without treatment of TNFα and inhibitors for downstream signaling. PE MVEC exhibited increased basal TNFα expression. Read More

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Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study.

Hypertens Pregnancy 2021 May 12:1-9. Epub 2021 May 12.

Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia.

: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia.: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester. Read More

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Determinants of pregnancy-induced hypertension on maternal and foetal outcomes in Hossana town administration, Hadiya zone, Southern Ethiopia: Unmatched case-control study.

PLoS One 2021 12;16(5):e0250548. Epub 2021 May 12.

Department of Health Management and Economics, School of Public Health, Tehran University of Medical Science, Tehran, Iran.

Background: Globally, 292,982 women die due to the complications of pregnancy and childbirth per year, out of those deaths 85% occurs in Sub Saharan Africa. In Ethiopia, pre-eclampsia accounts for 11% of direct maternal deaths.

Objective: To determine maternal and foetal outcomes of pregnancy-induced hypertension among women who gave birth at health facilities in Hossana town administration. Read More

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Effect of L-Arginine supplementation in pregnant women with chronic hypertension and previous placenta vascular disorders receiving Aspirin prophylaxis: a randomized control trial.

Minerva Obstet Gynecol 2021 May 12. Epub 2021 May 12.

Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy.

Background: The aim of the study is to evaluate the effects of supplementation with Arginine (L-Arg) 3g, (together with Magnesium (Mg) 350 mg and Salicilate (Sal) 100 mg) on maternal blood pressure (BP), uterine artery doppler PI and neonatal outcomes in women with high-risk pregnancy for chronic hypertension (CH) and other previous placenta vascular disorders (PVD) already treated with low dose of aspirin (LDA), as recommended by guidelines.

Methods: We enrolled women affected by CH and other previous PVD referred to the High-Risk Clinic of the Mother-Infant Department of the University of Modena and Reggio Emilia from September 2017 to June 2019. The study design was a controlled, randomized trial of oral supplementation of L-Arg 3g (together with Mg 350 mg and Sal extract 100 mg) + LDA 100 mg/die versus only LDA 100 mg/die. Read More

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Obstetric and long-term graft outcomes in pregnant kidney transplant recipients: a single-center experience.

Clin Transplant 2021 May 12:e14349. Epub 2021 May 12.

Gazi University, Faculty of Medicine, Department of Nephrology, Ankara, Turkey.

Background: Kidney transplantation (KT) is the best option for many women with end-stage renal disease desiring pregnancy. The aim of this study was to investigate obstetric and graft outcomes among KT recipient women in our center.

Methods: Maternal and fetal data were assessed in 29 pregnancies of 18 female KT recipients. Read More

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Growth from birth to 6 months of infants with and without intrauterine preeclampsia exposure.

J Dev Orig Health Dis 2021 May 12:1-5. Epub 2021 May 12.

Women's and Children's Health, St George Hospital, Sydney, Australia.

Intrauterine preeclampsia exposure affects the lifelong cardiometabolic health of the child. Our study aimed to compare the growth (from birth to 6 months) of infants exposed to either a normotensive pregnancy or preeclampsia and explore the influence of being born small for gestational age (SGA). Participants were children of women participating in the Post-partum, Physiology, Psychology and Paediatric follow-up cohort study. Read More

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Lupus-like membranous nephropathy. Is it lupus? Report of 5 cases in a reference hospital in Mexico.

Lupus 2021 May 12:9612033211013584. Epub 2021 May 12.

Hospital Central "Dr. Ignacio Morones Prieto" and Faculty of Medicine, Universidad Autónoma de San Luis Potosí, S.L.P., México.

Lupus nephritis requires antinuclear antibodies as classification criteria. There is a group of patients with nephrotic syndrome and conclusive histopathological findings for lupus nephritis, without classification criteria for systemic lupus erythematosus (SLE) or extrarenal manifestations. These groups of patients have been described as "lupus-like" nephritis or "renal-limited lupus nephritis". Read More

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Exosomal miR-486-5p derived from human placental microvascular endothelial cells regulates proliferation and invasion of trophoblasts via targeting IGF1.

Hum Cell 2021 May 11. Epub 2021 May 11.

Department of Obstetrics, Guangdong Woman and Children Hospital, No. 521 Xingnan Avenue, Guangzhou, 510000, Guangdong, China.

Preeclampsia (PE) is a serious complication of pregnancy. Exosomes are known to be upregulated in PE. In this study, we sought to investigate the effect of miR-486-5p from human placental microvascular endothelial cells, on the function of trophoblast cells. Read More

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Preeclampsia and Its Complications Exacerbate Development of Postpartum Depression: A Retrospective Cohort Study.

Biomed Res Int 2021 22;2021:6641510. Epub 2021 Apr 22.

The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Background: Hypertensive disorders were proved to be associated with the development of depression. But it is unclear if pregnancy-induced hypertensive diseases, especially preeclampsia (PE), will affect postpartum moods. We aimed to determine the incidence rate of postpartum depression (PPD) in PE patients and comprehensively evaluate the association between PPD and PE, including its severity and complications. Read More

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Identification and comparison of circular RNAs in preeclampsia.

PeerJ 2021 20;9:e11299. Epub 2021 Apr 20.

Department of Obstetrics, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.

Background: Preeclampsia (PE) is a pregnancy-specific syndrome, belongs to the gestational hypertension diseases category and is considered among the causes of maternal and perinatal mortality and morbidity. However, the pathogenesis of PE is still vague.

Methods: In the present study, the circular RNA (circRNA) expression patterns of normal pregnant women and PE patients were investigated using whole RNA sequencing. Read More

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Incidence and risk factors for severe preeclampsia, HELLP syndrome and eclampsia at preterm and term gestation: a population-based study.

Am J Obstet Gynecol 2021 May 8. Epub 2021 May 8.

Department of Obstetrics and Gynaecology, University of British Columbia, and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Background: A majority of previous studies of severe preeclampsia, eclampsia and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome were hospital-based or included a relatively small number of women. Large population-based studies examining gestational age-specific incidence patterns and risk factors for these severe pregnancy complications are lacking.

Objectives: To assess gestational age-specific incidence rates and risk factors for severe preeclampsia, HELLP syndrome, and eclampsia. Read More

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Pregnancy Outcomes in Undifferentiated Connective Tissue Disease Compared to Systemic Lupus Erythematosus: A Single Academic Center's Experience.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Duke University Medical Center, Durham, United States.

Objective: Systemic lupus erythematosus (SLE) patients have more pregnancy complications than healthy patients. Data regarding pregnancy outcomes in women with undifferentiated connective tissue disease (UCTD) are more limited, and existing studies are concentrated in Italy and predominantly in patients with a new diagnosis. We compared pregnancy outcomes for UCTD and SLE patients with established disease. Read More

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sFlt-1/PlGF ratio as a predictive and prognostic marker for preeclampsia.

J Obstet Gynaecol Res 2021 May 10. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Gachon University of Gil Medical Center, Incheon, South Korea.

Objective: Preeclampsia is clinically unpredictable and associated with adverse outcomes. Pregnant women with suspected preeclampsia require intensive monitoring or hospitalization for elevated sFlt-1 (soluble fms-like tyrosine kinase-1) to PlGF (placental growth factor) ratios before symptoms arise. We aimed to determine the sFlt-1/PlGF ratio's usefulness in predicting adverse pregnancy outcomes in preeclampsia. Read More

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Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study.

Fertil Steril 2021 Apr 12. Epub 2021 Apr 12.

Maternal-Fetal Medicine Unit, Department Obstetrics and Gynecology, Hospital Universitario Puerta de Hierro.Majadahonda, Madrid, Spain. Electronic address:

Objective: To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes).

Design: Multicenter, prospective, observational study.

Setting: 78 centers participating in the Spanish COVID19 Registry. Read More

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Routine Third Trimester Sonogram: Friend or Foe.

Obstet Gynecol Clin North Am 2021 Jun;48(2):359-369

Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, The Rosie Hospital, Robinson Way, Cambridge CB2 0SW, United Kingdom. Electronic address:

Several risk factors for adverse pregnancy outcomes can be identified by a routine third trimester ultrasound scan. However, there is also potential for harm, anxiety, and additional health care costs through unnecessary intervention due to false positive results. The evidence base informing the balance of risks and benefits of universal screening is inadequate to fully inform decision making. Read More

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Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.

Pregnancy Hypertens 2021 May 5;24:126-134. Epub 2021 May 5.

Department of Physiology, Augusta University, United States.

Preeclampsia (PE) is a disorder of pregnancy, which is categorized by hypertension and proteinuria or signs of end-organ damage. Though PE is the leading cause of maternal and fetal morbidity and mortality, the mechanisms leading to PE remain unclear. The present study examined the contribution of dietary protein source (casein versus wheat gluten) to the risk of developing maternal syndrome utilizing two colonies of Dahl salt-sensitive (SS/JrHsdMcwi) rats. Read More

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Factors associated with acute kidney injury during delivery or the postpartum period: A case control study.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 27;261:200-204. Epub 2021 Apr 27.

Department of Obstetrics, Maternal Medicine Service, St George's Hospital, Blackshaw Road, London, SW17 0QT, United Kingdom. Electronic address:

Introduction: To investigate the incidence of risk factors associated with acute kidney injury(AKI) occurring during the intrapartum or the immediate postpartum period.

Material And Methods: A retrospective case control study in a tertiary UK hospital of pregnant women identified with AKI in labour or in the postpartum period between July 2019 and June 2020 was carried out. Women identified with pregnancy related AKI (pr-AKI) in labour or postpartum were compared with a matched cohort of women with no evidence of pr-AKI, using multiple regression analysis. Read More

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A longitudinal analysis of arterial stiffness and wave reflection in preeclampsia: identification of Changepoints.

Metabolism 2021 May 7:154794. Epub 2021 May 7.

Division of Experimental Medicine, Department of Medicine, McGill University, 1001 Décarie Boulevard, Montreal, Quebec, Canada H4A 3J1; Division of Internal Medicine, Department of Medicine, McGill University, 1001 Décarie Boulevard, Montreal, Quebec, Canada H4A 3J1. Electronic address:

Purpose: Preeclampsia (PrE) is a leading complication of pregnancy characterized by vascular dysfunction. Characterizing the longitudinal changes in vascular function prior to PrE onset is critical to the identification of optimal timepoints for vascular assessment and the development of effective early screening strategies.

Methods: In this prospective longitudinal study of women with singleton high-risk pregnancies, arterial stiffness and wave reflection parameters were assessed using applanation tonometry at 10-13 weeks' gestation and repeated every 4 weeks throughout pregnancy. Read More

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Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study.

PLoS Med 2021 May 10;18(5):e1003641. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk of preterm delivery (PTD) although the exact pathomechanism is not yet understood. Women with untreated CIN also seem to have an increased risk of PTD. It is unclear whether this is attributable to human papillomavirus (HPV) infection or other factors. Read More

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