41,246 results match your criteria Pregnancy Preeclampsia


Dental amalgams and risk of gestational hypertension in the MIREC study.

Pregnancy Hypertens 2020 Apr 28;21:84-89. Epub 2020 Apr 28.

Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, QC, Canada; Centre de recherche du CHUS, Department of Obstetrics and Gynecology, Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address:

Background: The potential association between the presence or replacement of dental amalgams and gestational hypertension (GH) is unclear.

Objective: To assess the association between the presence or replacement of dental amalgams and the risk of GH in a prospective cohort study.

Methods: We assessed dental amalgam status (presence or replacement), blood mercury concentrations, and measured blood pressure (BP) in 1817 pregnant women recruited in 10 Canadian cities. Read More

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http://dx.doi.org/10.1016/j.preghy.2020.04.015DOI Listing

Evaluation of the Prognostic Value of the sFlt-1/PlGF Ratio in Early-Onset Preeclampsia.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Obstetrics and Gynecology, Paule de Viguier Maternity, CHU Toulouse, Toulouse, France.

Objective:  Increased expression of soluble fms-like tyrosine kinase 1 (sFlt-1), associated with a decrease in placental growth factor (PlGF), plays a key role in the pathogenesis of preeclampsia (PE). We evaluated the prognostic value of the sFlt-1/PlGF ratio for the onset of adverse maternofetal outcomes (AMFO) in case of early-onset PE with attempted expectant management.

Study Design:  From October 2016 through November 2018, all singleton pregnancies complicated by early-onset PE (before 34 weeks of gestation) were included in a cohort study. Read More

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http://dx.doi.org/10.1055/s-0040-1709696DOI Listing

ACC-AHA Diagnostic Criteria for Hypertension in Pregnancy Identifies Patients at Intermediate Risk of Adverse Outcomes.

Am J Perinatol 2020 May 23. Epub 2020 May 23.

Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective:  The aim of the study is to compare maternal and neonatal outcomes among patients who are normotensive, hypertensive by Stage I American College of Cardiology-American Heart Association (ACC-AHA) criteria, and hypertensive by American College of Obstetricians and Gynecologists (ACOG) criteria.

Study Design:  Secondary analysis of a prospective first trimester cohort study between 2007 and 2010 at three institutions in Baltimore, MD, was conducted. Blood pressure at 11 to 14 weeks' gestation was classified as (1) normotensive (systolic blood pressure [SBP] <130 mm Hg and diastolic blood pressure [DBP] <80 mm Hg); (2) hypertensive by Stage I ACC-AHA criteria (SBP 130-139 mm Hg or DBP 80-89 mm Hg); or (3) hypertensive by ACOG criteria (SBP ≥140 mm Hg or DBP ≥90 mm Hg). Read More

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http://dx.doi.org/10.1055/s-0040-1709465DOI Listing

Pregnancy After Kidney Transplantation With Maternal and Pediatric Outcomes: A Single-Center Experience.

Transplant Proc 2020 May 19. Epub 2020 May 19.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdańsk, Poland.

Outcomes of pregnancies after kidney transplantation were evaluated. Thirty-one pregnancies in 26 women were noted. The mean maternal age at pregnancy was 31 ± 5 years (range, 23-44 years). Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.122DOI Listing

Vitamin D-Binding Protein in Pregnancy and Reproductive Health.

Nutrients 2020 May 20;12(5). Epub 2020 May 20.

Monash Centre for Health Research and Implementation (MCHRI) and Centre of Cardiovascular Research and Education in Therapeutics (CCRET), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168 VIC, Australia.

Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Read More

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http://dx.doi.org/10.3390/nu12051489DOI Listing

Placental Microarray Profiling Reveals Common mRNA and lncRNA Expression Patterns in Preeclampsia and Intrauterine Growth Restriction.

Int J Mol Sci 2020 May 20;21(10). Epub 2020 May 20.

Dirección de Investigación, Instituto Nacional de Perinatología, Mexico City 11000, Mexic.

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are major contributors to perinatal morbidity and mortality. These pregnancy disorders are associated with placental dysfunction and share similar pathophysiological features. The aim of this study was to compare the placental gene expression profiles including mRNA and lncRNAs from pregnant women from four study groups: PE, IUGR, PE-IUGR, and normal pregnancy (NP). Read More

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http://dx.doi.org/10.3390/ijms21103597DOI Listing

Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity.

Cancers (Basel) 2020 May 18;12(5). Epub 2020 May 18.

Oncology, Rambam Health Care Center, Haifa 3109601, Israel.

Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes of chemotherapy during pregnancy have demonstrated increased gestational complications including preeclampsia and intrauterine growth retardation. Read More

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http://dx.doi.org/10.3390/cancers12051277DOI Listing

Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.

Authors:

Obstet Gynecol 2020 Jun;135(6):e237-e260

Hypertensive disorders of pregnancy constitute one of the leading causes of maternal and perinatal mortality worldwide. It has been estimated that preeclampsia complicates 2-8% of pregnancies globally (). In Latin America and the Caribbean, hypertensive disorders are responsible for almost 26% of maternal deaths, whereas in Africa and Asia they contribute to 9% of deaths. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003891DOI Listing

Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin Summary, Number 222.

Authors:

Obstet Gynecol 2020 Jun;135(6):1492-1495

Hypertensive disorders of pregnancy constitute one of the leading causes of maternal and perinatal mortality worldwide. It has been estimated that preeclampsia complicates 2-8% of pregnancies globally (). In Latin America and the Caribbean, hypertensive disorders are responsible for almost 26% of maternal deaths, whereas in Africa and Asia they contribute to 9% of deaths. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003892DOI Listing

Chemotherapy for breast cancer during pregnancy induces vascular alterations and impaired development of placental villi: A preliminary histopathological study.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 29;250:155-161. Epub 2020 Apr 29.

Division of Pathology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Objective: To evaluate histological alterations in placentas of women affected by breast cancer and treated with chemotherapy during pregnancy.

Study Design: We retrospectively reviewed histological slides of 23 placentas of patients affected by breast cancer and treated with chemotherapy during pregnancy and 23 control placentas of women without breast cancer and with physiological pregnancies of the same gestational age.

Results: All the patients had breast ductal infiltrating carcinoma, 19 of 23 cases had a G3 cancer. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.04.012DOI Listing

The association between maternal renal function and pregnancy outcomes in type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2020 May 19:108225. Epub 2020 May 19.

Department of Perinatal Medicine, Mercy Health, 163 Studley Road, Heidelberg, VIC, 3084, Australia; Department of Endocrinology and Diabetes, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address:

Aims: To investigate the prognostic value of estimated glomerular filtration rate (eGFR) and albuminuria in determining pregnancy outcomes in women with type 1 and type 2 diabetes.

Methods: An observational study of pregnant women with type 1 (n = 92) and type 2 diabetes (n = 106) who delivered between 2004 and 2014 at a single tertiary obstetric centre. Clinical and biochemical characteristics were determined and related to major obstetric outcomes: preeclampsia, preterm birth <32 and <37 weeks, and neonatal intensive care admission. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108225DOI Listing

Screening for pre-eclampsia at 11-13 weeks' gestation: use of PAPP-A, PlGF or both.

Ultrasound Obstet Gynecol 2020 May 22. Epub 2020 May 22.

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Objective: First-trimester screening for preeclampsia (PE) is useful because treatment of the high-risk group with aspirin reduces the rate of early-PE with delivery at <34 weeks' gestation by about 80% and preterm-PE with delivery at <37 weeks by 60%. In previous studies we reported that the best way of identifying the high-risk group is by a combination of maternal factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and serum placental growth factor (PLGF). An alternative biochemical marker is pregnancy associated plasma protein-A (PAPP-A), which is widely used as part of early screening for trisomies. Read More

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http://dx.doi.org/10.1002/uog.22093DOI Listing

Investigation of human trophoblast invasion in vitro.

Hum Reprod Update 2020 May 22. Epub 2020 May 22.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK.

Background: In humans, inadequate trophoblast invasion into the decidua is associated with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction (FGR) and stillbirth. The mechanisms regulating invasion remain poorly understood, although interactions with the uterine environment are clearly of central importance. Extravillous trophoblast (EVT) cells invade the uterus and transform the spiral arteries. Read More

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http://dx.doi.org/10.1093/humupd/dmaa017DOI Listing

Placental Pathology in COVID-19.

Am J Clin Pathol 2020 May 22. Epub 2020 May 22.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy.

Methods: Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa089DOI Listing

Low-dose aspirin for prevention of pre-eclampsia: when over the counter just isn't.

Authors:
Joanna Girling

Drug Ther Bull 2020 May 21. Epub 2020 May 21.

Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Middlesex, UK

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http://dx.doi.org/10.1136/dtb.2020.000003DOI Listing

Oxygen and development of the human placenta.

Reproduction 2020 May 1. Epub 2020 May 1.

E Jauniaux, EGA Institute for Women's Health, University College London, London, United Kingdom of Great Britain and Northern Ireland.

Development of the human placenta takes place in contrasting oxygen concentrations at different stages of gestation, from ~20 mmHg during the first trimester rising to ~60 mmHg at the start of the second trimester before gradually declining to ~40 mmHg at term. In view of these changes the early placenta has been described as 'hypoxic'. However, placental metabolism is heavily glycolytic, supported by the rich supply of glucose from the endometrial glands, and there is no evidence of energy compromise. Read More

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http://dx.doi.org/10.1530/REP-20-0153DOI Listing

Vitamin D, preeclampsia and prematurity: A systematic review and meta-analysis of observational and interventional studies.

Midwifery 2020 May 6;87:102707. Epub 2020 May 6.

Andalusian Research, Development and Innovation Plan. CTS 367, University of Granada. Granada, Spain. Electronic address:

Background: Vitamin D has important functions outside of bone metabolism. Deficiency has been associated with several adverse outcomes during pregnancy such as preeclampsia and prematurity. There is an increasing body of literature on this topic with studies performed to date having produced contradictory results. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102707DOI Listing

How would you treat a pregnant woman with a rupture of cranial aneurysm at the second trimester of pregnancy? A case report.

World Neurosurg 2020 May 10. Epub 2020 May 10.

Acıbadem University Atakent Hospital, Department of Neurosurgery.

Background: Cerebral aneurysm and aneurysm rupture have rarely been reported in the literature during pregnancy. Aneurysm might rupture and may cause intracranial hemorrhage during or after pregnancy. Aneurysmal subarachnoid hemorrhage (aSAH) during pregnancy presents a challenge regarding treatment and management. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.238DOI Listing

Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia.

Cell Death Discov 2020 13;6:35. Epub 2020 May 13.

2School of Biosciences, Weifang Medical University, Weifang, 261053 Shandong China.

Preeclampsia (PE) is a life-threatening disorder of human pregnancy affecting 5-8% of all pregnancies. Currently, PE remains an elusive complicated and heterogenous medical condition with no early marker or symptoms is recognized for this serious pregnancy complications. Here, we profiled the plasma miRNA expression patterns associated with preeclampsia and found 16 miRNAs were deregulated ( < 0. Read More

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http://dx.doi.org/10.1038/s41420-020-0269-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220944PMC

Association of preeclampsia with infant APOL1 genotype in African Americans.

BMC Med Genet 2020 May 20;21(1):110. Epub 2020 May 20.

Departments of Inflammation and Immunity and Nephrology, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, USA.

Background: Black women in the United States and Africa are at an increased risk for preeclampsia. Allelic variants in the gene for apolipoprotein LI, APOL1, are found only in populations of African ancestry, and have been shown to contribute significant risk for kidney disease. Recent studies suggest these APOL1 variants also may contribute risk for preeclampsia. Read More

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http://dx.doi.org/10.1186/s12881-020-01048-4DOI Listing

Pre-eclampsia screening in the first trimester - preemptive action to prevent the peril.

J Matern Fetal Neonatal Med 2020 May 20:1-9. Epub 2020 May 20.

Department of Fetal Medicine, Nahas Hospital, Malappuram, Kerala, India.

Pre-eclampsia complicating 2-5% of pregnancies is an obstetrical syndrome associated with deleterious short-and long-term consequences to the gravid women, the fetus and the neonate. Majority of the obstetrical complications occur in early pre-eclampsia (requiring delivery <34 weeks). The risk factor based approach recommended by the professional organizations for pre-eclampsia screening has shown suboptimal clinical performance. Read More

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http://dx.doi.org/10.1080/14767058.2020.1767059DOI Listing

Immunomorphological Features of the Placenta in Allogeneic Pregnancy as the Background for the Development of Obstetric Complications.

Pathobiology 2020 May 20:1-12. Epub 2020 May 20.

I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation.

Objective: To study the structural and immunohistochemical features of placentas in women after assisted reproductive technology (ART) with allogeneic eggs (oocyte donation and surrogate motherhood).

Study Design: The study involved 89 women whose pregnancy occurred as a result of in vitro fertilization (IVF) with a donor egg in a surrogate motherhood program (IVF-SM, n = 47 patients) or oocyte donation (IVF-DO, n = 42). The comparison group consisted of 21 patients in whom pregnancy occurred as a result of IVF with their own egg (IVF-OE). Read More

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http://dx.doi.org/10.1159/000506776DOI Listing

Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the EAGeR trial.

Am J Obstet Gynecol 2020 May 17. Epub 2020 May 17.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Epidemiology Branch, Division of Intramural Population Health Research, Bethesda, MD.

Background: Platelet activation may play a role in the pathophysiology of placenta-mediated obstetric complications, as evidenced by the efficacy of aspirin for preventing preeclampsia, but published data regarding the relationship between biomarkers for platelet activation and adverse obstetric outcomes are sparse. Specifically, it is unknown whether pre-pregnancy biomarkers of platelet activation are associated with adverse pregnancy outcomes.

Objectives: To determine: 1) whether maternal plasma concentrations of platelet factor 4 are associated with risk of placenta-mediated adverse obstetric outcomes, and 2) whether these associations are modified by low-dose aspirin. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.026DOI Listing

A preeclampsia risk prediction model for Chinese pregnant patients with systemic lupus erythematosus.

Arthritis Care Res (Hoboken) 2020 May 20. Epub 2020 May 20.

Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Objective: To screen for a high risk of preeclampsia (PE) in women with systemic lupus erythematosus (SLE).

Methods: Five hundred thirteen antenatal care records of pregnant SLE patients were obtained and the data were randomly assigned to either a development set (n=342) or a validation set (n=171). PE predictors were identified with stepwise regression, and coefficient B of each variable was used to establish a prediction model and risk scoring system. Read More

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http://dx.doi.org/10.1002/acr.24265DOI Listing

Late pregnancy screening for preeclampsia with a urinary point-of-care test for misfolded proteins.

PLoS One 2020 20;15(5):e0233214. Epub 2020 May 20.

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York City, New York, United States of America.

The aim was to describe and assess a new late pregnancy point-of-care urinary preeclampsia screening test. Urine samples were collected from a consecutive series of 1,532 pregnant women hospitalized at 20-41 weeks gestation in a Chinese single obstetric unit. A simple disposable Congo red based device was newly developed and employed to prospectively test misfolded proteins in pregnant women's urine. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233214PLOS

2019 Water and Electrolyte Homeostasis Section Trainee Award: "Influences of Environmental Factors During Preeclampsia".

Am J Physiol Regul Integr Comp Physiol 2020 May 20. Epub 2020 May 20.

Physiology, Medical College of Wisconsin, United States.

Preeclampsia is a pregnancy-specific disorder that impacts 5-8% of pregnancies and has long-term cardiovascular and metabolic implications for both mother and fetus. The mechanisms are unclear; however, it is believed that preeclampsia is characterized by abnormal vascularization during placentation resulting in the manifestation of clinical signs such as hypertension, proteinuria and endothelial dysfunction. While there is no current cure to alleviate the clinical signs, an emerging area of interest in the field is the influence of environmental factors including diet on the risk of preeclampsia. Read More

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http://dx.doi.org/10.1152/ajpregu.00020.2020DOI Listing

Regulation of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia.

Eur Rev Med Pharmacol Sci 2020 May;24(9):5062-5070

Department of Obstetrics, The Children & Women's Healthcare of Laiwu City, Laiwu, P.R. China.

Objective: To explore the regulatory effect of magnesium sulfate combined with nifedipine and labetalol on disease-related molecules in serum and placenta in the treatment of preeclampsia.

Patients And Methods: Altogether 100 patients with preeclampsia admitted to the Children & Women's Healthcare of Laiwu City were selected. They were divided into control group and experimental group according to different treatment methods. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21199DOI Listing

CD97 Is Decreased in Preeclamptic Placentas and Promotes Human Trophoblast Invasion Through PI3K/Akt/mTOR Signaling Pathway.

Reprod Sci 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, People's Republic of China.

Preeclampsia (PE) is a pregnancy disorder leading to the morbidity and mortality. Despite the development of the understanding of etiology, the only effective treatment of PE is the delivery of the placenta. An improved mastery on the regulation of trophoblast invasion could be meaningful to alleviate the disease burden of PE. Read More

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http://dx.doi.org/10.1007/s43032-020-00183-wDOI Listing

Romiplostim for management of refractory immune thrombocytopenic purpura in the immediate postpartum period.

BMJ Case Rep 2020 May 18;13(5). Epub 2020 May 18.

Department of OB/GYN, Trinity Health of New England, Hartford, Connecticut, USA

We present a case of a pregnant woman with chronic immune thrombocytopenic purpura and chronic hypertension who developed pre-eclampsia with severe features warranting delivery. Her overall clinical picture and liver enzymes improved in the immediate postpartum period, however, aggressively progressing thrombocytopenia posed a diagnostic dilemma to the interdisciplinary care team. After failing to respond to first-line therapies including high-dose corticosteroids and intravenous immunoglobulin, she was successfully managed with a trial of the thrombopoietin receptor agonist, Romiplostim. Read More

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http://dx.doi.org/10.1136/bcr-2020-234335DOI Listing

Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery.

BMC Pregnancy Childbirth 2020 May 19;20(1):302. Epub 2020 May 19.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.

Background: The data on the association between the microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) during pregnancy and risk of preeclampsia (PE) is limited.

Methods: We, therefore, conducted a prospective nested case control study during Sep 2017 to Dec 2018 to examine the association between plasma TMAO measured during pregnancy and the risk of PE. Total of 17 patients diagnosed with early onset PE (EOPE), 49 with late onset PE (LOPE) and 198 healthy controls were enrolled. Read More

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http://dx.doi.org/10.1186/s12884-020-02997-7DOI Listing

Vitamin D Effects on the Immune System from Periconception through Pregnancy.

Nutrients 2020 May 15;12(5). Epub 2020 May 15.

Hannover Medical School, Gynaecology Research Unit, Carl-Neuberg-Str.1, D-30625 Hannover, Germany.

Vitamin D is a well-known secosteroid and guardian of bone health and calcium homeostasis. Studies on its role in immunomodulatory functions have expanded its field in recent years. In addition to its impact on human physiology, vitamin D influences the differentiation and proliferation of immune system modulators, interleukin expression and antimicrobial responses. Read More

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http://dx.doi.org/10.3390/nu12051432DOI Listing

Immune tolerance at the maternal-placental interface in healthy pregnancy and pre-eclampsia.

J Obstet Gynaecol Res 2020 May 19. Epub 2020 May 19.

UMAE Hospital de Gineco-Obstetricia No. 3, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Aim: The objective of this review is to describe the immunological mechanisms which facilitate maternal tolerance at the maternal-placental interface, and to discuss how these mechanisms are disrupted in pre-eclampsia.

Methods: A literature review was performed based on the analysis of papers available on PubMed. The most important and relevant studies regarding the immunological mechanisms which facilitate maternal tolerance in healthy pregnancy and pre-eclampsia are presented in this article. Read More

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http://dx.doi.org/10.1111/jog.14309DOI Listing

Cystatin C as an indicator of renal damage in pre-eclampsia.

Hypertens Pregnancy 2020 May 19:1-6. Epub 2020 May 19.

High Risk Pregnancy Study Group, Federal University of Minas Gerais, Minas Gerais, Brazil.

: To assess the predictive abilities of serum and urinary cystatin C levels for glomerular lesions in pregnant women with pre-eclampsia.: In this study, kidney function markers were compared between38 pregnant women with pre-eclampsia and 22 healthy pregnant women.: The serum and urine levels of cystatin C and urea were significantly higher in the pre-eclampsia group than in the control group. Read More

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http://dx.doi.org/10.1080/10641955.2020.1766488DOI Listing

Glycosylated fibronectin point-of-care test for diagnosis of preeclampsia in a low-resource setting: a prospective Southeast Asian population study.

BJOG 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.

Objective: To determine the performance of a glycosylated fibronectin (GlyFn) point-of-care (POC) test for preeclampsia (PE) in a large Southeast Asian cohort (India) in comparison to previously described biomarkers.

Design: 798 pregnant women at 20+ weeks of gestation were enrolled in a prospective case-control study. Study participants included 469 normotensive women with urinary mg protein/mmol creatinine ratio <0. Read More

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http://dx.doi.org/10.1111/1471-0528.16323DOI Listing

Combined Immature Platelet Fraction and Schistocyte Count to Differentiate Pregnancy-Associated Thrombotic Thrombocytopenic Purpura from Severe Preeclampsia/Haemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome (SPE/HELLP).

Indian J Hematol Blood Transfus 2020 Apr 5;36(2):316-323. Epub 2019 Oct 5.

5Department of Clinical Pathology, Misr University for Science and Technology (MUST), Giza, Egypt.

The occurrence of thrombotic microangiopathy (TMA) in pregnancy is an unfortunate emergency condition. Proper diagnosis is mandatory which requires the consideration of two overlapping diagnoses: severe preeclampsia/haemolysis, elevated liver enzymes, and low platelet syndrome (SPE/HELLP) and thrombotic thrombocytopenic purpura (TTP). The long turn-around times of ADAMTS13 testing precludes the timely distinction between the two conditions. Read More

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http://dx.doi.org/10.1007/s12288-019-01200-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229135PMC

Maternal near miss and mortality attributable to hypertensive disorders in a tertiary hospital, Tanzania; a cross-sectional study.

BMC Pregnancy Childbirth 2020 May 18;20(1):301. Epub 2020 May 18.

Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

Background: Hypertensive disorders in pregnancy is the second most common direct cause of maternal deaths accounting for 14% of maternal deaths worldwide. Severe pre-eclampsia and eclampsia are among the hypertensive disorders in pregnancy causing significant morbidity and mortality, hence categorized as Maternal Near Miss. At Muhimbili National Hospital these are the leading causes of maternal deaths accounting for 19. Read More

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http://dx.doi.org/10.1186/s12884-020-02930-yDOI Listing

Aortic Hemodynamics and Cognitive Performance in Postmenopausal Women: Impact of Pregnancy History.

Am J Hypertens 2020 May 18. Epub 2020 May 18.

Department of Kinesiology, University of Wisconsin-Madison, Madison, WI.

Background: Studies demonstrate an association between aortic hemodynamics and cognitive function. The impact of pregnancy history on this association is unknown.

Methods: Postmenopausal women (age 59±5 y; years since last pregnancy 35±3) with either a history of preeclampsia (PE; n=34) or with a history of a normotensive pregnancy (NP; n=30) underwent cognitive testing: Letter-Number Sequencing, Digit Span, Trail Making Test, and letter and category fluency. Read More

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http://dx.doi.org/10.1093/ajh/hpaa081DOI Listing

Temperature and preeclampsia: Epidemiological evidence that perturbation in maternal heat homeostasis affects pregnancy outcome.

PLoS One 2020 18;15(5):e0232877. Epub 2020 May 18.

Clinical Research Center, Soroka University Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel.

Introduction: This study aims to determine the association between temperature and preeclampsia and whether it is affected by seasonality and rural/urban lifestyle.

Methods: This cohort study included women who delivered at our medical center from 2004 to 2013 (31,101 women, 64,566 deliveries). Temperature values were obtained from a spatiotemporally resolved estimation model performing predictions at a 1×1km spatial resolution. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232877PLOS

Wharton's jelly area and its association with placental morphometry and pathology.

Placenta 2020 May 23;94:34-38. Epub 2020 Mar 23.

Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Introduction: Wharton's jelly (WJ) is the mucoid connective tissue that surrounds the vessels in the human umbilical cord and provides protection from compression and torsion in response to fetal movement. WJ is known to be altered in the presence of pregnancy complications such as gestational diabetes mellitus and preeclampsia. The present study examined associations between the cross-sectional area of WJ measured by ultrasound and postpartum placental pathology and morphometry. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.03.008DOI Listing

The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension.

Hypertens Pregnancy 2020 May 18:1-5. Epub 2020 May 18.

Department of Medicine, University of Debrecen, Hungary.

: The aim of the study was to compare the complication of Antihypertensive drug; in pregnant women with chronic hypertension.: This retrospective cohort study was performed on 300 pregnant women  with chronic hypertension. Results:  a relative risk of preeclampsia among methyldopa group was 3. Read More

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http://dx.doi.org/10.1080/10641955.2020.1766489DOI Listing

Spontaneous Ovarian Hyperstimulation Syndrome in a Partial Molar Pregnancy With Early Onset Severe Pre-eclampsia at 15 Weeks Gestation.

Mil Med 2020 May 18. Epub 2020 May 18.

Department of Obstetrics and Gynecology, San Antonio Military Medical Center, 3551 Roger Brooke Drive, San Antonio, TX 78234.

Ovarian hyperstimulation syndrome is a well-known entity in assisted reproductive technology. However, it is unusual for this entity to occur without any medications that stimulate follicle stimulating hormone. Herein, we describe a case where a partial molar pregnancy with high human chorionic gonadotropin promiscuously activated follicle stimulating hormone receptors has resulted in spontaneous ovarian hyperstimulation syndrome. Read More

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http://dx.doi.org/10.1093/milmed/usaa008DOI Listing

Myeloid-derived suppressor cells in obstetrical and gynecological diseases.

Am J Reprod Immunol 2020 May 17:e13266. Epub 2020 May 17.

Insitute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200080, People's Republic of China.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid-origin cells which have immunosuppressive activities in several conditions, such as cancer and inflammation. Recent research has also associated MDSCs with numerous obstetrical and gynecological diseases. During pregnancy, MDSCs accumulate to ensure maternal-fetal immune tolerance, whereas they are decreased in patients who suffer from early miscarriage or preeclampsia. Read More

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http://dx.doi.org/10.1111/aji.13266DOI Listing

Exposure to wood smoke particles leads to inflammation, disrupted proliferation and damage to cellular structures in a human first trimester trophoblast cell line.

Environ Pollut 2020 May 11;264:114790. Epub 2020 May 11.

Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden. Electronic address:

The ongoing transition to renewable fuel sources has led to increased use of wood and other biomass fuels. The physiochemical characteristics of biomass combustion derived aerosols depends on appliances, fuel and operation procedures, and particles generated during incomplete combustion are linked to toxicity. Frequent indoor wood burning is related to severe health problems such as negative effects on airways and inflammation, as well as chronic hypoxia and pathological changes in placentas, adverse pregnancy outcome, preterm delivery and increased risk of preeclampsia. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114790DOI Listing

The relationship between patterns of insulin secretion and risks of gestational diabetes mellitus.

Int J Gynaecol Obstet 2020 May 16. Epub 2020 May 16.

Department of Gynecology & Obstetrics, Shenzhou City Hospital, Shenzhou, Hebei, China.

Objective: To evaluate patterns of insulin secretion in pregnancy and analyze the association between insulin patterns and risks of gestational diabetes mellitus (GDM).

Methods: A prospective study was conducted to collect and analyze pregnant women's materials from January 2015 to December 2018. Pregnant women were grouped according to results of 75-g oral glucose tolerance test at 24-28 weeks of pregnancy: normal glucose tolerance (NGT) and GDM. Read More

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http://dx.doi.org/10.1002/ijgo.13200DOI Listing

Methyldopa as an inductor of postpartum depression and maternal blues: A review.

Biomed Pharmacother 2020 May 12;127:110196. Epub 2020 May 12.

Department of Hepatobiliary and General Surgery, Faculty of Medicine Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Purpose: Pregnancy and time period right after labour are connected with some dangerous states, such as: pregnancy-induced hypertension (PIH), which afflict 6-10 % of pregnant women and mood disorders where postpartum depression occurs among 10-15 % of women after labour and so-called baby blues afflicts around 43 % of them. Scientists tried to link those diseases which afflicts thousands of women per year, and the linking factor appears to be methyldopa which is the first choice treatment of PIH. Recent study showed that 778 % of pregnant women treated with methyldopa suffered to postpartum depression. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110196DOI Listing

An external exposome-wide association study of hypertensive disorders of pregnancy.

Environ Int 2020 May 12;141:105797. Epub 2020 May 12.

Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.

It is widely recognized that exogenous factors play an important role in the development of hypertensive disorders of pregnancy (HDP). However, only a few external environmental factors have been studied, often separately, with no attempt to examine the totality of the external environment, or the external exposome. We conducted an external exposome-wide association study (ExWAS) using the Florida Vital Statistics Birth Records including 819,399 women with live births in 2010-2013. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105797DOI Listing

Urinary placental growth factor determined in the first trimester of pregnancy as a predictor of preeclampsia.

Pregnancy Hypertens 2020 May 7;21:63-67. Epub 2020 May 7.

Bogomolets National Medical University, Kyiv, Ukraine. Electronic address:

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http://dx.doi.org/10.1016/j.preghy.2020.05.003DOI Listing

Fetal growth restriction as a diagnostic criterion for preeclampsia.

Pregnancy Hypertens 2020 May 7;21:58-62. Epub 2020 May 7.

Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center, Yokohama, Japan.

Objectives: Currently, no unified set of criteria to classify preeclampsia (PE) exists. Further, no consensus has been reached whether fetal growth restriction (FGR) should be included in diagnostic criteria for PE. We examined the adequacy of including FGR in diagnostic criteria for PE. Read More

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http://dx.doi.org/10.1016/j.preghy.2020.05.002DOI Listing

Antiphospholipid Syndrome.

Authors:
Michelle Petri

Transl Res 2020 May 12. Epub 2020 May 12.

Johns Hopkins University School of Medicine, Division of Rheumatology, 1830 E. Monument Street, Suite 7500, Baltimore, Maryland 21286, USA. Electronic address:

Antiphospholipid syndrome (APS) is one of the more common acquired causes of hypercoagulability. Its major presentations are thrombotic (arterial, venous or microvascular) and pregnancy morbidity (miscarriages, late intrauterine fetal demise, and severe pre-eclampsia). Classification criteria include three different antiphospholipid antibodies: lupus anticoagulant; anticardiolipin; and anti-beta 2 glycoprotein I. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.04.006DOI Listing

Analysis of SIRT1 Expression in Plasma and in an Model of Preeclampsia.

Oxid Med Cell Longev 2020 28;2020:4561083. Epub 2020 Apr 28.

Department of Pharmacology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior, Botucatu, São Paulo 18680-000, Brazil.

Preeclampsia (PE) is a pregnancy-specific disorder that affects 3-8% expecting mothers worldwide being one of the main causes of maternal and fetal morbidity and mortality. The search for altered circulating molecules in PE is an important target to better understand the pathophysiology of this disease. Therefore, we evaluated Sirtuin-1 (SIRT1) concentration in plasma from healthy pregnant (HP) women, gestational hypertensive women (GH), and preeclampsia women (PE) via enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1155/2020/4561083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204130PMC