1,959 results match your criteria Pregnancy Hyperemesis Gravidarum


Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.

Geburtshilfe Frauenheilkd 2019 Apr 26;79(4):382-388. Epub 2019 Feb 26.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. Read More

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http://dx.doi.org/10.1055/a-0830-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461465PMC

The relationship of hyperemesis gravidarum with sleep disorders, anxiety and depression.

J Obstet Gynaecol 2019 Apr 15:1-6. Epub 2019 Apr 15.

b Department of Biostatistics, Faculty of Medicine , Hitit University , Çorum , Turkey.

The purpose of this study was to compare patients who were diagnosed with hyperemesis gravidarum (HG) with the control group by identifying anxiety, depression, sleep disorder levels and the relationship between them. This study involved 98 first-trimester pregnant women (46 HG patients and 52 control group patients) who applied to the Hitit University Medicine Faculty Obstetrics and Gynecology clinic. Statistically significant differences were found between HG patients and the control group according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores (p < . Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1572725DOI Listing
April 2019
4 Reads

Burden, risk factors and outcomes of hyperemesis gravidarum in low-income and middle-income countries (LMICs): systematic review and meta-analysis protocol.

BMJ Open 2019 Apr 4;9(4):e025841. Epub 2019 Apr 4.

Department of Nursing, Debre Berhan University, Debre Berhan, Ethiopia.

Introduction: Hyperemesis gravidarum (HG) is a pregnancy condition characterised by excessive nausea and vomiting resulting in dehydration, weight loss and serious adverse pregnancy outcomes including termination of pregnancies. Even though evidence in low-income and middle-income countries (LMICs) is limited, the prevalence of HG in pregnancy ranges from 0.3% to 10. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02584
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http://dx.doi.org/10.1136/bmjopen-2018-025841DOI Listing
April 2019
4 Reads
2.063 Impact Factor

Serotonin-estrogen interactions: What can we learn from pregnancy?

Biochimie 2019 Apr 1. Epub 2019 Apr 1.

INRS-Institut Armand-Frappier, 531, boulevard des Prairies, Laval, QC, H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment (Cinbiose), Université du Québec à Montréal, C.P.8888, succ. Centre-Ville, Montréal, QC, H3C 3P8, Canada. Electronic address:

We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.03.023DOI Listing

Complications in Early Pregnancy.

Emerg Med Clin North Am 2019 May;37(2):219-237

Department of Emergency Medicine, Canton-Potsdam Hospital, 50 Leroy Street, Potsdam, NY 13676, USA. Electronic address:

Early in pregnancy women frequently experience nausea, vomiting, and vaginal bleeding. Nausea and vomiting can be mild, managed by dietary modifications and medications, or severe, requiring intravenous fluids and medications. Care should be used when selecting medications for nausea to avoid additional side effects or potential harm to the developing fetus. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.004DOI Listing
May 2019
5 Reads

The effects of threatened abortions on pregnancy outcomes.

Ginekol Pol 2019 Mar 22. Epub 2019 Mar 22.

Izmir provincial health directorate, Izmir, Turkey, Turkey.

Objectives: The effects of first trimester threatened abortions on prenatal and postnatal pregnancy outcomes.

Material And Methods: Data from 24.835 pregnant women were retrospectively analysed. Read More

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http://dx.doi.org/10.5603/GP.a2019.0035DOI Listing
March 2019
2 Reads

Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 12;236:84-93. Epub 2019 Mar 12.

Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands; Korsakoff Center Slingedael, Lelie Care Group, Rotterdam, the Netherlands.

Pregnant women have an increased demand for thiamine. In hyperemesis gravidarum (HG) thiamine rapidly depletes, which can lead to Wernicke's Encephalopathy (WE). Our objective was to systematically review the signs and symptoms of WE in HG. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.006DOI Listing
March 2019
1 Read

Use of ondansetron during pregnancy and the risk of major congenital malformations: A systematic review and meta-analysis.

Reprod Toxicol 2019 Mar 5;86:1-13. Epub 2019 Mar 5.

Mothersafe, The Royal Hospital for Women, Sydney, New South Wales, Australia; School of Women's and Children's Health University of New South Wales, Australia.

Aims: To investigate whether ondansetron use during pregnancy is associated with increased rates of major or subgroups of malformations.

Methods: PubMed/MEDLINE, Cochrane and Reprotox databases were searched. Observational studies comprising an exposed and control group (healthy and/or disease-matched) were included. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.03.001DOI Listing
March 2019
2 Reads

Women's perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study.

Scand J Prim Health Care 2019 Mar 1;37(1):30-40. Epub 2019 Mar 1.

b PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy , University of Oslo , Oslo , Norway.

Objective: Hyperemesis gravidarum (HG) affects 0.3-3% of pregnant women and is a leading cause of hospitalization in early pregnancy. The aim of the study was to investigate women's treatment and management of HG, as well as the consequences of HG on women's daily life. Read More

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http://dx.doi.org/10.1080/02813432.2019.1569424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454401PMC
March 2019
2 Reads

Hair cannabinoid concentrations in emergency patients with cannabis hyperemesis syndrome.

CJEM 2019 Feb 26:1-5. Epub 2019 Feb 26.

¶Department of Medicine,Queen's University,Kingston,ON.

Objectives: Cannabis hyperemesis syndrome is characterized by bouts of protracted vomiting in regular users of cannabis. We wondered whether this poorly understood condition is idiosyncratic, like motion sickness or hyperemesis gravidarum, or the predictable dose-response effect of prolonged heavy use.

Methods: Adults with an emergency department visit diagnosed as cannabis hyperemesis syndrome, near-daily use of cannabis for ≥6 months, and ≥2 episodes of severe vomiting in the previous year were age- and sex-matched to two control groups: RU controls (recreational users without vomiting), and ED controls (patients in the emergency department for an unrelated condition). Read More

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http://dx.doi.org/10.1017/cem.2018.479DOI Listing
February 2019
1 Read

Frequency of pregnancy-related complications causing acute kidney injury in pregnant patients at a tertiary care hospital.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):194-201

Department of Nephrology, The Kidney Centre Postgraduate Training Institute, Karachi, Pakistan.

Acute kidney injury (AKI) in pregnancy is associated with significant maternal morbidity and mortality. Several studies from worldwide have shown different frequencies of the causes of pregnancy-related AKI (PRAKI). The present study aimed to provide local data on frequency of causes of PRAKI. Read More

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February 2019
2 Reads

Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population-based study.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

Division of Epidemiology & Public Health, University of Nottingham, Nottingham, UK.

Objectives: To assess how nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) are managed and treated across primary and secondary care.

Design: Population-based pregnancy cohort.

Setting: Medical records (CPRD-GOLD) from England. Read More

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http://dx.doi.org/10.1111/1471-0528.15662DOI Listing
February 2019
1 Read

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

Clin Nutr 2019 Feb 10. Epub 2019 Feb 10.

Gastrointestinal Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK; MRC/ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UK, UK. Electronic address:

Many theories have been advanced concerning the cause of Charlotte Brontë's death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tuberculosis), but there is no evidence, other than circumstantial, to support this diagnosis. A diagnosis of Addison's disease, caused by tuberculosis of the adrenals, has been proposed, but this is unlikely, since it does not fit well with two and a half months of severe anorexia, nausea and vomiting, followed by remission of these symptoms and eventual death. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.01.027DOI Listing
February 2019
1 Read

Complete recovery in Wernicke's encephalopathy complicating hyperemesis gravidarum.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Obstetrics and Gynecology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India.

Wernicke's encephalopathy (WE) is an uncommon neurological complication in pregnancies complicated with hyperemesis due to thiamine deficiency. In women with hyperemesis, inadvertent glucose administration prior to thiamine supplementation triggers the development of neurological manifestations. Delay in the diagnosis can lead to maternal morbidity, and in one-third of cases may lead to persistence of some neurological deficit. Read More

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http://dx.doi.org/10.1136/bcr-2018-227530DOI Listing
February 2019
7 Reads

Safety and effectiveness of Japanese herbal Kampo medicines for treatment of hyperemesis gravidarum.

Int J Gynaecol Obstet 2019 May 8;145(2):182-186. Epub 2019 Mar 8.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Objectives: To investigate whether Japanese Kampo medicines, including Sho-hange-kabukuryou-to, Touki-syakuyaku-san, and Hange-kouboku-to, are safe for fetuses, and whether these medicines reduce hospitalizations and medical costs in pregnant women with hyperemesis gravidarum.

Methods: We used the Japan Medical Data Center database to extract data for pregnant women (aged ≥19 years) admitted to obstetric clinics or hospitals for delivery between January 1, 2005, and December 31, 2016. Eligible patients were classified into three groups: Kampo medicines for hyperemesis gravidarum, other medicines for hyperemesis gravidarum, and without hyperemesis gravidarum. Read More

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http://dx.doi.org/10.1002/ijgo.12781DOI Listing
May 2019
4 Reads

Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus.

Endocr J 2019 Mar 29;66(3):253-258. Epub 2019 Jan 29.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Although hyperemesis gravidarum (HG), an extreme form of morning sickness, is a common complication during pregnancy, HG associated simultaneous onset of rhabdomyolysis and diabetes insipidus due to electrolyte abnormalities are rare. A 34-year-old woman with severe HG at 17 weeks of gestation complicated with appetite loss, weight reduction by 17 kg, general fatigue, myalgia, weakness and polyuria was identified to have simultaneous hypophosphatemia (1.6 mg/dL) and hypokalemia (2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0496DOI Listing
March 2019
2 Reads

Obstetric and Neonatal Outcomes of Pregnant Indian Pilgrims: A three-year experience at the Indian Hajj Medical Mission.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e355-e361. Epub 2018 Dec 19.

Department of Clinical Microbiology & Infectious Diseases, Army College of Medical Sciences & Base Hospital, New Delhi, India.

Objectives: The , an annual mass gathering of Muslim pilgrims, is known for its high morbidity and mortality rates. However, pregnant women sometimes participate in this pilgrimage, despite guidelines that discourage such an undertaking due to potential fetomaternal complications. This study aimed to evaluate fetomaternal outcomes among pregnant Indian pilgrims. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307628PMC
August 2018
4 Reads

Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder.

Reprod Toxicol 2019 03 27;84:59-64. Epub 2018 Dec 27.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The purpose of this study was to follow up on the reporting of neurodevelopmental disorders in children exposed in utero to Hyperemesis Gravidarum (HG). This was an exploratory descriptive study whereby neurodevelopmental outcomes of 267 children delivered by 177 mothers with HG were compared to neurodevelopmental outcomes from 93 children delivered by 60 unaffected mothers. Similar to at age 8, the children (now 12) exposed in utero to HG had over 3-fold increase in odds of neurodevelopmental disorders including attention, anxiety, sensory, sleep difficulty, and social development delay/social anxiety. Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.12.009DOI Listing
March 2019
4 Reads

Points & Pearls: First trimester pregnancy emergencies: recognition and management

Emerg Med Pract 2019 Jan 1;21(Suppl 1):1-2. Epub 2019 Jan 1.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

Timely management of patients presenting to the ED while in their first trimester of pregnancy can improve outcomes for both the patient and the fetus. Common obstetric problems encountered include vaginal bleeding and miscarriage, ectopic pregnancy and pregnancy of undetermined location, and nausea and vomiting of pregnancy, including hyperemesis gravidarum. Optimal diagnostic approaches and management strategies are covered, including which antiemetics are safe to give in pregnancy. Read More

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January 2019
7 Reads

Maternal type 1collagen N-terminal telopeptide levels in severe hyperemesis gravidarum.

BMC Pregnancy Childbirth 2018 Dec 20;18(1):502. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Background: Nausea and vomiting occur 50-90% during the first trimester of pregnancy. However, patients with hyperemesis gravidarum (HG) may be hospitalized at an incidence rate of 0.8-2% before the 20th week of gestational age. Read More

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https://bmcpregnancychildbirth.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12884-018-2149-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302387PMC
December 2018
15 Reads

First trimester pregnancy emergencies: recognition and management.

Authors:
Ryan Pedigo

Emerg Med Pract 2019 Jan 1;21(1):1-20. Epub 2019 Jan 1.

Director of Undergraduate Medical Education, Harbor-UCLA Medical Center, Torrance, CA; Assistant Professor of Emergency Medicine, David Geffen School of Medicine, Los Angeles, CA.

Timely management of patients presenting to the ED while in their first trimester of pregnancy can improve outcomes for both the patient and the fetus. Common obstetric problems encountered include vaginal bleeding and miscarriage, ectopic pregnancy and pregnancy of undetermined location, and nausea and vomiting of pregnancy, including hyperemesis gravidarum. Optimal diagnostic approaches and management strategies are covered, including which antiemetics are safe to give in pregnancy. Read More

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January 2019
3 Reads

Burden of Infections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia.

Int J Chronic Dis 2018 12;2018:5183713. Epub 2018 Nov 12.

Addis Ababa University, College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia.

Background: Early detection and treatment of ( infection in women of child bearing ages may reduce the risk of maternal health disorder. This study was conducted to determine the burden of infections and associated risk factors among women of child bearing ages in Kolfe Keranio Subcity Woreda 9 Health Centers, Addis Ababa, Ethiopia.

Methods: Facility based cross sectional study design was conducted from April to October 2015. Read More

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http://dx.doi.org/10.1155/2018/5183713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260533PMC
November 2018

Management of severe pregnancy sickness and hyperemesis gravidarum.

BMJ 2018 Nov 30;363:k5000. Epub 2018 Nov 30.

Amsterdam UMC, University of Amsterdam, Obstetrics and Gynaecology, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/bmj.k5000DOI Listing
November 2018
2 Reads

Patient Preferences and Experiences in Hyperemesis Gravidarum Treatment: A Qualitative Study.

J Pregnancy 2018 30;2018:5378502. Epub 2018 Oct 30.

Department of Obstetrics and Gynaecology, University Medical Centers Amsterdam, University of Amsterdam, Amsterdam, Netherlands.

Introduction: Hyperemesis gravidarum (HG) medical therapies are currently of limited effect, which creates a larger role for patient preferences in the way HG care is arranged. This is the first study using in-depth interviews to investigate patients' preferences and experiences of HG treatment.

Materials And Methods: We conducted individual in-depth interviews among women who had been hospitalized for HG in North Holland at least once in the past 4 years. Read More

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https://www.hindawi.com/journals/jp/2018/5378502/
Publisher Site
http://dx.doi.org/10.1155/2018/5378502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234451PMC
April 2019
8 Reads

Under-recognized Etiology of Altered Mental Status in a Patient with Alcoholism.

Clin Pract Cases Emerg Med 2018 Nov 16;2(4):341-343. Epub 2018 Oct 16.

Beaumont Health System, Department of Emergency Medicine, Royal Oak, Michigan.

Wernicke's encephalopathy is an important condition for the emergency physician (EP) to consider in patients at risk for malnutrition. A 60-year-old man with history of alcoholism presented with word-finding difficulties, dysmetria, ataxia, and personality changes. After treatment with high-dose thiamine, his neurological status returned to his baseline. Read More

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https://escholarship.org/uc/item/2rh7882w
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http://dx.doi.org/10.5811/cpcem.2018.8.39266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230355PMC
November 2018
14 Reads

Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.

Wellcome Open Res 2018 21;3:123. Epub 2018 Sep 21.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge Addenbrooke's Hospital Cambridge, Cambridge, CB2 0QQ, UK.

Although nausea and vomiting are very common in pregnancy, their pathogenesis is poorly understood. We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene is implicated in hyperemesis gravidarum, are associated with nausea and vomiting. Blood samples for the measurement of GDF15 and human chorionic gonadotrophin (hCG) concentrations were obtained early in the second trimester (median 15. Read More

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https://wellcomeopenresearch.org/articles/3-123/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14818.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171563PMC
September 2018
6 Reads

[PR-EMPTIVE TREATMENT FOR HYPEREMESIS GRAVIDARUM].

Harefuah 2018 Oct;157(10):638-639

Motherisk Israel, Clinical Pharmacology Unit, Assaf Harofe Hospital.

Background: Hyperemesis gravidarum (HG) affects around 1% of pregnant women. The experience is traumatic, and many women hesitate to start a subsequent pregnancy in view of the tendency of HG to re-occur.

Objectives: A 25 year old woman who experienced HG in her previous pregnancy was very afraid to start a second pregnancy, as she considered the termination of the first, traumatic pregnancy. Read More

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October 2018
5 Reads

Hyperemesis Gravidarum.

Nutr Clin Pract 2019 Apr 18;34(2):226-241. Epub 2018 Oct 18.

Department of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Nausea and vomiting of pregnancy affect the majority of pregnancies, while the most severe version, hyperemesis gravidarum (HG), affects a much smaller subset of women. Despite the prevalence of nausea and vomiting of pregnancy and the severe consequences of HG, the pathophysiology of these conditions is not fully understood. Currently, it is thought that a combination of hormonal factors accounts for their development. Read More

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http://dx.doi.org/10.1002/ncp.10205DOI Listing
April 2019
2 Reads

Recurrent Nausea and Vomiting in a Pregnant Woman with Chronic Marijuana Use.

Case Rep Obstet Gynecol 2018 16;2018:9746062. Epub 2018 Sep 16.

Texas Tech University Health Sciences Center, School of Medicine, Department of Obstetrics and Gynecology, 1400 South Coulter Street, Amarillo, TX 79106, USA.

Background: Cannabinoid hyperemesis syndrome is a condition characterized by chronic cannabis use and cyclic episodes of nausea, vomiting, and abdominal pain, relieved by compulsive bathing. The syndrome is likely to be underdiagnosed in pregnant women due to its similarity with hyperemesis gravidarum in the presentation.

Case: We report a 20-year-old pregnant woman with multiple admissions for recurrent nausea and vomiting who was observed to be taking frequent hot showers. Read More

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http://dx.doi.org/10.1155/2018/9746062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165623PMC
September 2018
4 Reads

Mirtazapine for Major Depression Developed After Hyperemesis Gravidarum.

Authors:
Ahmed Naguy

Am J Ther 2018 Sep 18. Epub 2018 Sep 18.

Al-Manara Centre, Kuwait Centre for Mental Health (KCMH), Kuwait City, Kuwait.

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http://dx.doi.org/10.1097/MJT.0000000000000860DOI Listing
September 2018
14 Reads
1.130 Impact Factor

Interventions for treating nausea and vomiting in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials.

Expert Rev Clin Pharmacol 2018 Nov 5;11(11):1143-1150. Epub 2018 Oct 5.

b School of Oral Health, College of Medicine, Nursing and Health Sciences , Fiji National University , Suva , Fiji.

Introduction: Several drugs were explored for their utility in treating nausea and vomiting in pregnancy (NVP). The present study is a network meta-analysis of such drugs.

Methods: Electronic databases were searched for randomized clinical trials that have compared active interventions (with placebo or other active interventions) for treating NVP. Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1
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http://dx.doi.org/10.1080/17512433.2018.1530108DOI Listing
November 2018
3 Reads

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum.

Geburtshilfe Frauenheilkd 2018 Sep 14;78(9):866-870. Epub 2018 Sep 14.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hyperemesis gravidarum (HG), a pregnancy complication characterized by severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies. It is associated with both maternal and fetal morbidity. HG is highly heritable and recurs in approximately 80% of women. Read More

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http://dx.doi.org/10.1055/a-0661-0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138473PMC
September 2018
3 Reads

Assessment of discharge treatment prescribed to women admitted to hospital for hyperemesis gravidarum.

Int J Clin Pract 2019 Jan 21;73(1):e13261. Epub 2018 Sep 21.

Division of Epidemiology & Public Health, City Hospital, University of Nottingham, Nottingham, UK.

Aims: Prescribing drug treatment for the management of hyperemesis gravidarum (HG), the most severe form of nausea and vomiting in pregnancy, remains controversial. Since most manufacturers do not recommend prescribing antiemetics during pregnancy, little is known regarding which treatments are most prevalent among pregnant patients. Here, we report for the first time, evidence of actual treatments prescribed in English hospitals. Read More

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http://doi.wiley.com/10.1111/ijcp.13261
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http://dx.doi.org/10.1111/ijcp.13261DOI Listing
January 2019
8 Reads
2.570 Impact Factor

Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report.

Cureus 2018 Jul 17;10(7):e2991. Epub 2018 Jul 17.

Surgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Wernicke's encephalopathy (WE) is a life-threatening acute or sub-acute neurological emergency characterized by ataxia, confusion, nystagmus, and ophthalmoparesis caused by thiamine deficiency. It was first described in 1881 by Carl Wernicke with alcohol being the most common cause. We present a rare case of a 35-year-old pregnant female who presented to our emergency department with a history of vomiting and loose motions for two weeks. Read More

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http://dx.doi.org/10.7759/cureus.2991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141217PMC
July 2018
3 Reads

Optimisation of hyperemesis gravidarum management through an emergency department setting.

BMJ Open Qual 2018 8;7(3):e000330. Epub 2018 Sep 8.

Emergency Department, Princess Royal University Hospital, Orpington, Kent, UK.

Hyperemesis gravidarum is a common condition characterised by severe nausea and vomiting. The referral process from the emergency department (ED) to obstetrics and gynaecology (O&G) can lead to treatment delays before the gynaecology team review the patient, resulting in unnecessary prolonged inpatient stays in O&G. This quality improvement project created a clinical pathway which optimised care of patients presenting with hyperemesis gravidarum in the ED at the Princess Royal University Hospital using a treatment protocol. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135454PMC
September 2018
4 Reads

The association between the degree of nausea in pregnancy and subsequent posttraumatic stress.

Arch Womens Ment Health 2018 Sep 17. Epub 2018 Sep 17.

Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

Hyperemesis gravidarum (HG) is a pregnancy condition characterised by severe nausea and vomiting during early pregnancy. The experience of HG is for many women a traumatic event. Few studies have investigated a possible association between HG and birth-related posttraumatic stress. Read More

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http://dx.doi.org/10.1007/s00737-018-0909-zDOI Listing
September 2018
4 Reads

Characteristics and Outcomes of Ptyalism Gravidarum.

Isr Med Assoc J 2018 Sep;20(9):573-575

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

Background: Ptyalism gravidarum (PG) is a condition of hypersalivation that affects pregnant women early in gestation. Symptoms include massive saliva volumes (up to 2 liters per day), swollen salivary glands, sleep deprivation, significant emotional distress, and social difficulties.

Objectives: To examine maternal and fetal characteristics and pregnancy outcomes of patients with PG. Read More

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September 2018
16 Reads

Interventions for treating hyperemesis gravidarum: a network meta-analysis of randomized clinical trials.

J Matern Fetal Neonatal Med 2018 Sep 25:1-7. Epub 2018 Sep 25.

b School of Oral Health, College of Medicine, Nursing and Health Sciences , Fiji National University , Suva , Fiji.

Background: Several interventions were explored in clinical trials for treating hyperemesis gravidarum (HG). The present study is a network meta-analysis of such interventions.

Methods: Electronic databases were searched for appropriate randomized clinical trials comparing interventions for treatment of patients with HG. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1519540DOI Listing
September 2018
17 Reads

Profound Hypokalaemia Resulting in Maternal Cardiac Arrest: A Catastrophic Complication of Hyperemesis Gravidarum?

Case Rep Obstet Gynecol 2018 29;2018:4687587. Epub 2018 Jul 29.

Obstetrics and Gynaecology Staff Specialist, Gold Coast University Hospital, Australia.

We present a case of a 39-year-old G8P6 Pacific Islander woman who at 15+5 weeks' gestation had an out-of-hospital cardiac arrest secondary to profound hypokalaemia which was associated with severe hyperemesis gravidarum (HG). Her clinical course after arrest was complicated by a second 5-minute cardiac arrest in the Intensive Care Unit (ICU) (pre-arrest potassium 1.8), anuric renal failure requiring dialysis, ischaemic hepatitis, and encephalopathy and unfortunately fetal demise and a spontaneous miscarriage on day 2 of admission. Read More

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https://www.hindawi.com/journals/criog/2018/4687587/
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http://dx.doi.org/10.1155/2018/4687587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087565PMC
July 2018
13 Reads

Recurrence patterns of hyperemesis gravidarum.

Am J Obstet Gynecol 2018 Nov 16;219(5):469.e1-469.e10. Epub 2018 Aug 16.

Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland.

Background: Hyperemesis gravidarum, excessive vomiting in pregnancy, affects approximately 0.3-3.0% of all pregnancies, but the risk is considerably higher in pregnancies following a hyperemetic pregnancy. Read More

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http://dx.doi.org/10.1016/j.ajog.2018.08.018DOI Listing
November 2018
24 Reads

Optic Discs Swelling Procrastinates Wernicke's Encephalopathy Associated with Hyperemesis Gravidarum: A Case Report and Review of Literature.

Cureus 2018 Jun 12;10(6):e2793. Epub 2018 Jun 12.

Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, MYS.

Wernicke's encephalopathy following severe hyperemesis gravidarum is an uncommon clinical entity. We describe a rare manifestation of optic discs swelling in a pregnant woman that has caused a diagnostic dilemma. With high index of suspicion of clinical manifestations and radiological evidences, a clinical diagnosis of Wernicke's encephalopathy was made. Read More

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http://dx.doi.org/10.7759/cureus.2793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089490PMC
June 2018
9 Reads

The Sustained Value of an Early Pregnancy Assessment Clinic in the Management of Early Pregnancy Complications: A 10-Year Retrospective Study.

J Obstet Gynaecol Can 2018 Aug;40(8):1017-1023

Maternal, Newborn and Teen Program, Department of Obstetrics and Gynaecology, North York General Hospital, Toronto, ON; Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Toronto, Toronto, ON. Electronic address:

Objective: This study sought to evaluate the sustained value of an early pregnancy assessment clinic (EPAC) in the management of early pregnancy complications and its effect on the incidence emergency room (ER) visits.

Methods: A 10-year retrospective study (January 2006 to December 2015) was conducted. The number of patients assessed, sources and reasons for referral, and treatments provided were reviewed. Read More

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http://dx.doi.org/10.1016/j.jogc.2017.12.002DOI Listing
August 2018
3 Reads

[Nausea and vomiting in pregnancy].

Rev Med Suisse 2018 Aug;14(614):1397-1400

Service des urgences, CHUV, 1011 Lausanne.

Nausea and vomiting in early pregnancy is a common condition at risk to be minimized by women or care providers. If not treated in the early stages, it can evolve to a severe condition with a morbidity risk for the mother and/or the fetus, and expose to public health consequences. Severe forms of nausea and vomiting and hyperemesis gravidarum are a clinical diagnosis with nonspecific manifestations in addition to biologic and metabolic consequences for mother and/or child. Read More

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August 2018
5 Reads

[Abnormal liver tests during pregnancy - emergency department decision making].

Rev Med Suisse 2018 Aug;14(614):1382-1385

Service de médecine interne générale, Département de médecine interne, réhabilitation et gériatrie, HUG, 1211 Genève 14.

Abnormal liver biochemical and function tests is common problem among patients in emergency department and can result from many different pathologies. In pregnant women, causes are sometime life-threating for the mother and the fetus. The role of emergency physician is : 1) to differentiate between serious (HELPPS syndrome, pre-eclampsia and eclampsia, acute fatty liver of pregnancy) and minor (intrahepatic cholestasis, hyperemesis gravidarum) pregnancy related liver disease and 2) to recognize non-pregnancy related liver disease. Read More

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August 2018
5 Reads

Late neurological deficit after attempted PICC insertion in the arm.

J Vasc Access 2019 Mar 3;20(2):226-228. Epub 2018 Aug 3.

5 Vascular Surgeon, Hospital Municipal Vila Santa Catarina / Hospital Israelita Albert Einstein, São Paulo, Brazil.

Introduction:: Insertion of central catheters in peripheral vessels is a common procedure performed for a variety of indications, including parenteral nutrition. Hyperemesis gravidarum may require parenteral nutrition in exceptional situations. Although globally safe, insertion of peripherally inserted central catheters (PICCs) can lead to complications. Read More

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http://dx.doi.org/10.1177/1129729818790404DOI Listing
March 2019
18 Reads

Wernicke's Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature.

Cureus 2018 May 9;10(5):e2597. Epub 2018 May 9.

Department of Neurology, University of Missouri, Columbia, USA.

Wernicke's encephalopathy (WE) is a rare neurological syndrome that presents in the setting of thiamine deficiency. Though alcoholism is the most common cause of this condition, a few other etiologies include malnutrition from other causes, hemodialysis, and hyperemesis gravidarum. In this case report, we aim to report a case of a young woman who developed WE in the setting of hyperemesis gravidarum (HG) that improved with thiamine replacement. Read More

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http://dx.doi.org/10.7759/cureus.2597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039156PMC
May 2018
5 Reads

Risk factors of new onset anxiety and anxiety exacerbation in the perinatal period: A systematic review and meta-analysis.

J Affect Disord 2018 10 18;238:626-635. Epub 2018 Jun 18.

Neuroscience Graduate Program, McMaster University, Ontario, Canada; Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Ontario, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, Canada. Electronic address:

Background: Even though more than 20% of women meet diagnostic criteria for an anxiety disorder during the perinatal period, very little is known about the predictors of these problems. As a result, we systematically reviewed the literature on risk factors for new onset anxiety and maternal anxiety exacerbation in the perinatal period.

Methods: PubMed, MEDLINE, PsycINFO, CINAHL, Ovid, ProQuest Portal, and Web of Science were searched for studies assessing risk factors for the development of new onset anxiety or anxiety worsening in women during pregnancy and the postpartum period. Read More

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http://dx.doi.org/10.1016/j.jad.2018.05.073DOI Listing
October 2018
23 Reads

Effect of severe hyperemesis gravidarum on maternal vascular endothelial health: evaluation of soluble adhesion molecules.

J Matern Fetal Neonatal Med 2018 Aug 13:1-5. Epub 2018 Aug 13.

d Department of Obstetrics and Gynecology , Erciyes University Medicine Faculity , Kayseri , Turkey.

Purpose: This study aimed to clarify the effect of severe hyperemesis gravidarum (sHG) on maternal vascular endothelial health with evaluation of soluble adhesion molecules.

Method: The study population consisted of two groups of pregnant participants between 18 and 35 years of age who were between 5 and 13 weeks of gestation: sHG group and a healthy control group. A group of 26 participants whose pregnancies were complicated by sHG was compared with 26 healthy participants regarding serum levels of the soluble adhesion molecules such as E-selectin, soluble intracellular cell adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule one (sVCAM-1), as well as other biochemical markers. Read More

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http://dx.doi.org/10.1080/14767058.2018.1494145DOI Listing
August 2018
2 Reads