36,123 results match your criteria Pregnancy Eclampsia


Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

J Photochem Photobiol B 2019 Mar 22;194:183-187. Epub 2019 Mar 22.

Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital of Shandong Province, Shandong, China. Electronic address:

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.013DOI Listing

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study.

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Department of Obstetrics and Gynecology , KasrAlAini Hospital Cairo University , Cairo , Egypt.

This is a cohort study which included 100 cases with pre-eclampsia (PE) and 100 controls, done to compare the antepartum and postpartum uterine artery (UtA) Doppler velocimetry between them. UtA PI and RI were measured before and within 48-72 h after delivery. There was a highly significant difference between the cases and controls, regarding the UtA RI (0. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1563054DOI Listing
April 2019
1 Read

Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
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http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
1 Read

Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the 'DO' component of DOHaD.

J Dev Orig Health Dis 2019 Apr;10(2):141-143

1Department of Obstetrics and Gynaecology, Maternal Fetal Medicine Unit,The Aga Khan University,Karachi,Pakistan.

Adverse intrauterine environment could serve as an important stimulus for postnatal altered health status and for increased susceptibility to long-term non-communicable diseases (NCDs). The notion is now recognized as the Developmental Origins of Health and Disease (DOHaD), which was first proposed by Sir David Barker. Since then, several scientific disciplines have strived to measure the magnitude of the early fetal programming and later risk of diseases. Read More

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http://dx.doi.org/10.1017/S2040174418000636DOI Listing
April 2019
1 Read

Acute kidney injury in patients with HELLP syndrome.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: To evaluate the risk factors and renal prognosis of acute kidney injury (AKI) in patients with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.

Methods: Women with HELLP syndrome over a 15-year period at Peking Union Medical College Hospital, China, were retrospectively studied.

Results: A total of 108 patients with HELLP syndrome were included. Read More

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http://link.springer.com/10.1007/s11255-019-02111-7
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http://dx.doi.org/10.1007/s11255-019-02111-7DOI Listing
April 2019
2 Reads

Practical approach to the prevention of preeclampsia: from screening to pharmaceutical intervention.

J Matern Fetal Neonatal Med 2019 Apr 15:1-7. Epub 2019 Apr 15.

a Weill Cornell Medicine in Qatar , Doha , Qatar.

Preeclampsia occurs in 3-8% of the pregnancies and is associated with a high rate of morbi-mortality, both for mothers and the fetus. Screening and prevention of patients at risk are the optimal way to reduce the morbi-mortality of this disease. To set-up a preventive approach to preeclampsia (PE), one has to identify using a screening strategy for the population at risk and propose them an appropriate therapeutic intervention that would bear a favorable benefits/risk ratio. Read More

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http://dx.doi.org/10.1080/14767058.2019.1588877DOI Listing
April 2019
1 Read

IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Placenta Lab, Department of Obstetrics, Jena University Hospital, 07740 Jena, Germany.

The IL-36 subfamily of cytokines has been recently described as part of the IL-1 superfamily. It comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), their receptor (IL-36R), and one antagonist (IL-36Ra). Although expressed in a variety of cells, the biological relevance of IL-36 cytokines is most evident in the communication between epithelial cells, dendritic cells, and neutrophils, which constitute the common triad responsible for the initiation, maintenance, and expansion of inflammation. Read More

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http://dx.doi.org/10.3390/ijms20071649DOI Listing
April 2019
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Vitamin D status in pregnant women visiting a tertiary care center of North Eastern India.

J Family Med Prim Care 2019 Feb;8(2):356-360

Department of Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Studies of vitamin D (VD) physiology suggest that effects of vitamin D deficiency (VDD) could be much broader than rickets including cardiovascular disease, cancers, diabetes, infection, and allergy and pregnancy complications. Data regarding the prevalence of hypovitaminosis in pregnancy are scanty especially in north eastern part of India. Therefore, this study has undertaken with the intention to find out prevalence and outcome of hypovitaminosis of VD in pregnancy. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_404_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436274PMC
February 2019
1 Read

Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy.

Case Rep Rheumatol 2019 11;2019:4914631. Epub 2019 Mar 11.

Department of Rheumatology, Showa University School of Medicine, Tokyo, Japan.

Polymyositis-dermatomyositis is extremely rare during pregnancy, and immunosuppressive therapy should be administered after carefully considering the effects on both the mother and fetus. Several reports have associated the disease activity with fetal prognosis, higher rates of eclampsia, preterm births, and fetal deaths. We report our experience with a patient who was diagnosed with polymyositis-dermatomyositis complicated by interstitial lung disease during pregnancy and was treated with a combination-immunosuppressant regimen. Read More

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http://dx.doi.org/10.1155/2019/4914631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432726PMC
March 2019
1 Read

Platelet function in preeclampsia - a systematic review and meta-analysis.

Platelets 2019 Apr 14:1-14. Epub 2019 Apr 14.

a Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Preeclampsia is a serious pregnancy-related complication. Platelets are potentially important in the pathogenesis of preeclampsia, and platelet function analyses may prove as sensitive preeclampsia biomarkers. This study aimed to systematically review and summarise the literature on platelet function markers in preeclampsia. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595561DOI Listing
April 2019
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Translating Maternal Mortality Review Into Quality Improvement Opportunities in Response to Pregnancy-Related Deaths in California.

J Obstet Gynecol Neonatal Nurs 2019 Apr 11. Epub 2019 Apr 11.

Objective: To describe quality improvement opportunities (QIOs) associated with the five leading causes of pregnancy-related death in California and the methods by which the QIOs were collected by the California Pregnancy-Associated Mortality Review committee.

Design: Qualitative, descriptive design using thematic analysis.

Sample: A total of 907 QIOs identified from 203 cases of pregnancy-related deaths from cardiovascular disease, preeclampsia/eclampsia, hemorrhage, venous thromboembolism, and sepsis that occurred in California from 2002 to 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.03.003DOI Listing

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Preeclampsia/Eclampsia.

J Obstet Gynecol Neonatal Nurs 2019 Apr 10. Epub 2019 Apr 10.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from preeclampsia/eclampsia by the California Pregnancy-Associated Mortality Review Committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 242 QIOs identified from 54 cases of pregnancy-related deaths from preeclampsia/eclampsia in California between 2002 and 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.02.008DOI Listing
April 2019
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Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.

PLoS One 2019 12;14(4):e0215326. Epub 2019 Apr 12.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215326PLOS
April 2019
2 Reads

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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An evaluation of whether a gestational weight gain of 5 to 9 kg for obese women optimizes maternal and neonatal health risks.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):126. Epub 2019 Apr 11.

College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, 77843-4475, USA.

Background: Maternal obesity has a wide range of health effects on both the pregnant woman and developing fetus. The clinical significance of these disorders, combined with a dramatically increasing prevalence of obesity among pregnant women has precipitated a major health crisis in the United States. The most commonly used recommendations for gestational weight gain were established by the Institute of Medicine (IOM) in 2009 and have become well known and often adopted. Read More

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http://dx.doi.org/10.1186/s12884-019-2273-zDOI Listing
April 2019
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Postpartum Cardiovascular Outcomes Among Women With Heart Disease from A Nationwide Study.

Am J Cardiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Medicine, Division of Cardiovascular Medicine, State University of New York, Stony Brook University Medical Center, Stony Brook, New York. Electronic address:

There is limited data on postpartum maternal postpartum major adverse cardiovascular and cerebrovascular events (MACCE) among women with heart disease (HD) in the US. Therefore, we aimed to determine the prevalence and predictors of MACCE in the US. The Nationwide Readmissions Databases (2010 to 2014) were screened for patients with and without HD undergoing delivery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193030
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http://dx.doi.org/10.1016/j.amjcard.2019.03.012DOI Listing
March 2019
3 Reads

Delayed Initiation of Hemodialysis in Pregnant Women with Chronic Kidney Disease: Logistical Problems Impact Clinical Outcomes. An Experience from an Emerging Country.

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Unidad de Investigación Médica en Enfermedades Nefrológicas, CMN Siglo XXI, 06720 CdMx, México.

Background: Chronic kidney disease (CKD) is associated with reduction of fertility and increased complications during pregnancy. The aim of this work is to analyze the clinical outcomes and risk factors in pregnant women who needed to start dialysis with different schedules in a public hospital in Mexico City, with particular attention on the interference of social and cultural elements as well as resource limitations.

Material And Methods: CKD women who needed dialysis in pregnancy over the period 2002⁻2014 and had with complete demographic and outcome data were included in this retrospective study. Read More

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http://dx.doi.org/10.3390/jcm8040475DOI Listing

Patterns and causes of hospital maternal mortality in Tanzania: A 10-year retrospective analysis.

PLoS One 2019 9;14(4):e0214807. Epub 2019 Apr 9.

National Institute for Medical Research, Headquarters, Dar es Salaam, Tanzania.

Background: Maternal mortality is among the most important public health concerns in Sub-Saharan Africa. There is limited data on hospital-based maternal mortality in Tanzania. The objective of this study was to determine the causes and maternal mortality trends in public hospitals of Tanzania from 2006-2015. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214807PLOS
April 2019
2 Reads

Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia.

Curr Pharm Des 2019 Apr 5. Epub 2019 Apr 5.

Department of Internal Medicine; Division of Pharmacology and Vascular Medicine, Erasmus MC University Medical Center, Rotterdam. Netherlands.

Background: Adequate development of the placenta is essential for optimal pregnancy outcome. Pre-eclampsia (PE) is increasingly recognized to be a consequence of placental dysfunction and can cause serious maternal and fetal complications during pregnancy. Furthermore, PE increases the risk of neonatal problems and has been shown to be a risk factor for cardiovascular disease of the mother later in life. Read More

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http://dx.doi.org/10.2174/1381612825666190405145228DOI Listing
April 2019
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DNA methylation-reprogrammed oxytocin receptor underlies insensitivity to oxytocin in pre-eclamptic placental vasculature.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Institute for Fetology and Department of Obstetrics and Gynecology, First Hospital of Soochow University, Suzhou, China.

Pre-eclampsia is associated with inadequate placental blood flow and placental ischaemia. Placental vascular tone is essential for maintaining adequate placental blood flow. Oxytocin is increased in placental system at late pregnancy and onset of labour, and presented strongly concentration-dependent contractions in placental vascular, suggesting that oxytocin could be involved in regulating placental vascular tone and circulation. Read More

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http://dx.doi.org/10.1111/jcmm.14299DOI Listing
April 2019
2 Reads

Serotonin-estrogen interactions: what can we learn from pregnancy?

Biochimie 2019 Apr 1. Epub 2019 Apr 1.

INRS-Institut Armand-Frappier, 531, Boulevard des Prairies, Laval, QC, H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment (Cinbiose), Université Du Québec à Montréal, C.P.8888, Succ. Centre-Ville, Montréal, QC, H3C 3P8, Canada. Electronic address:

We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.03.023DOI Listing

Immune imbalance is associated with the development of preeclampsia.

Medicine (Baltimore) 2019 Apr;98(14):e15080

State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Preeclampsia (PE) is characterized by hypertension and proteinuria. It affects about 5% to 8% of pregnancies and causes maternal and perinatal mortality and morbidity. The immune imbalance and excessive inflammatory response play vital roles in the pathogenesis of PE. Read More

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http://dx.doi.org/10.1097/MD.0000000000015080DOI Listing
April 2019
2 Reads

Metformin reduces maternal weight gain in obese pregnant women: a systematic review and meta-analysis of two randomized controlled trials.

Diabetes Metab Res Rev 2019 Apr 3:e3164. Epub 2019 Apr 3.

Department of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.

Obese pregnant women are likely to face several gestational and neonatal complications. Metformin is an effective oral anti-hyperglycemic agent that is considered to be effective during pregnancy. The aim of our study was to evaluate the effect of metformin on obstetric and perinatal outcomes in obese pregnant women. Read More

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http://dx.doi.org/10.1002/dmrr.3164DOI Listing
April 2019
3 Reads

Pharmacotherapy for hypertension in pregnant patients: special considerations.

Expert Opin Pharmacother 2019 Apr 3:1-20. Epub 2019 Apr 3.

a Department of Pharmacology and Toxicology, School of Medicine , Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV , Madrid , Spain.

Introduction: Hypertensive disorders of pregnancy (HDP) represent a major cause of maternal, fetal and neonatal morbidity and mortality and identifies women at risk for cardiovascular and other chronic diseases later in life. When antihypertensive drugs are used during pregnancy, their benefit and harm to both mother and fetus should be evaluated. Areas covered: This review summarizes the pharmacological characteristics of the recommended antihypertensive drugs and their impact on mother and fetus when administered during pregnancy and/or post-partum. Read More

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http://dx.doi.org/10.1080/14656566.2019.1594773DOI Listing
April 2019
8 Reads

The efficacy of the Dietary Approaches to Stop Hypertension diet with respect to improving pregnancy outcomes in women with hypertensive disorders.

J Hum Nutr Diet 2019 Apr 3. Epub 2019 Apr 3.

Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Background: The DASH (Dietary Approaches to Stop Hypertension) diet serves as a dietary pattern for the prevention and control of hypertension. The present study aimed to investigate whether the DASH diet can improve the outcomes of pregnancy with gestational hypertension (GH) and chronic hypertension.

Methods: The current randomised controlled clinical trial was performed in 85 pregnant women diagnosed with GH and chronic hypertension between July 2015 and December 2017. Read More

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http://dx.doi.org/10.1111/jhn.12654DOI Listing
April 2019
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Maternal Cardiac Function after Normal Delivery, Preeclampsia, and Eclampsia: A Prospective Study.

J Pregnancy 2019 3;2019:9795765. Epub 2019 Mar 3.

I.M. Sechenov First Moscow State Medical University, Department of Obstetrics, Gynecology and Perinatology, Moscow, Russia.

Introduction: The aim of this study is to assess maternal cardiac function in the postpartum period, after 2 and 6 months in the parturient with preeclampsia and eclampsia.

Materials And Methods: Prospective study: 90 postpartum women after preeclampsia and eclampsia and 55 patients after an uncomplicated pregnancy. The parameters of maternal hemodynamics were recorded on days 1, 3, 5, 9, and 14 of postpartum period, after 2 and 6 months. Read More

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https://www.hindawi.com/journals/jp/2019/9795765/
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http://dx.doi.org/10.1155/2019/9795765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420982PMC
March 2019
6 Reads

Analysis of the Epigenome in Multiplex Pre-eclampsia Families Identifies , , and as Novel Candidate Risk Genes.

Front Genet 2019 19;10:227. Epub 2019 Mar 19.

The Curtin UWA Centre for Genetic Origins of Health and Disease, Faculty of Health and Medical Sciences, Curtin University, The University of Western Australia, Perth, WA, Australia.

Pre-eclampsia is a serious heritable disorder that affects 5-8% of pregnancies worldwide. While classical genetic studies have identified several susceptibility genes they do not fully explain the heritability of pre-eclampsia. An additional contribution to risk can be quantified by examining the epigenome, in particular the methylome, which is a representation of interactions between environmental and genetic influences on the phenotype. Read More

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http://dx.doi.org/10.3389/fgene.2019.00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434177PMC
March 2019
4 Reads

Hypertensive Disorders of Pregnancy.

Emerg Med Clin North Am 2019 May;37(2):301-316

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, Suite 200; 6th Floor, Baltimore, MD 21201, USA; Department of Internal Medicine, University of Maryland School of Medicine, 110 South Paca Street, Suite 200; 6th Floor, Baltimore, MD 21201, USA.

The 4 categories of hypertensive disorders of pregnancy are chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia. These disorders are among the leading causes of maternal and fetal morbidity and mortality. Proper diagnosis in the emergency department is crucial in order to initiate appropriate treatment to reduce the potential harm to the mother and the fetus. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.008DOI Listing
May 2019
2 Reads

Factors predicting recurrence of gestational diabetes in a high-risk multi-ethnic population.

Aust N Z J Obstet Gynaecol 2019 Apr 1. Epub 2019 Apr 1.

South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

Background: Women with gestational diabetes mellitus (GDM) have an increased risk of adverse pregnancy outcomes. This study examined predictors for GDM recurrence at their next pregnancy in a multi-ethnic population. Clinical outcomes of women with GDM at the index as well as the subsequent pregnancies were also compared. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajo.12973
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http://dx.doi.org/10.1111/ajo.12973DOI Listing
April 2019
6 Reads

Viability of diagnostic decision support for antenatal care in rural settings: findings from the Bliss4Midwives Intervention in Northern Ghana.

J Glob Health 2019 Jun;9(1):010420

Athena Institute, Vrije Universiteit, Amsterdam, the Netherlands.

Background: Antenatal screening is useful for early identification and management of high-risk pregnancies. In low-resource settings, provision of the full complement of tests is limited and diagnostic referrals incure additional costs for pregnant women. We assessed the viability of Bliss4Midwives (B4M) - a point-of-care diagnostic decision support device for decentralized screening of pre-eclampsia, gestational diabetes and anaemia during antenatal care (ANC). Read More

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http://dx.doi.org/10.7189/jogh.09.010420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437754PMC

[Acute fatty liver in pregnancy].

Ugeskr Laeger 2019 Mar;181(12)

This case report of a 31-year-old primiparous woman discusses the importance of early diagnosis and treatment of acute fatty liver in pregnancy (AFLP) to prevent maternal or/and foetal death. AFLP is a rare disease, which is characterised by maternal liver dysfunction and/or failure. Because of similar symptoms and laboratory findings AFLP may mimic and is often mistaken for 1) the more frequent HELLP syndrome with haemolysis, elevated liver enzymes and low platelet levels and 2) and severe pre-eclampsia. Read More

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March 2019
2 Reads

Risk Factors, Imaging Findings, and Sex Differences in Spontaneous Coronary Artery Dissection.

Am J Cardiol 2019 Mar 8. Epub 2019 Mar 8.

Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Spontaneous coronary artery dissection (SCAD) is increasingly being recognized. However, data supporting diagnosis and management are scarce. We analyze a contemporary and comprehensive SCAD registry to advance the understanding of SCAD risk factors, angiographic appearance, and gender differences. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.040DOI Listing
March 2019
4 Reads
3.276 Impact Factor

Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective.

J Steroid Biochem Mol Biol 2019 Mar 26;190:152-160. Epub 2019 Mar 26.

Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Centre for Women's & Newborn Health, Birmingham Health Partners, Birmingham Women's & Children's Foundation Hospital, Edgbaston, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK. Electronic address:

Vitamin D deficiency is linked to adverse pregnancy outcomes such as pre-eclampsia (PET) but remains defined by serum measurement of 25-hydroxyvitamin D3 (25(OH)D3) alone. To identify broader changes in vitamin D metabolism during normal and PET pregnancies we developed a relatively simple but fully parametrised mathematical model of the vitamin D metabolic pathway. The data used for parametrisation were serum vitamin D metabolites analysed for a cross-sectional group of women (n = 88); including normal pregnant women at 1 st (NP1, n = 25) and 3rd trimester (NP3, n = 21) and pregnant women with PET (n = 22), as well as non-pregnant female controls (n = 20). Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.024DOI Listing
March 2019
3 Reads

Incidence of eclampsia and related complications across 10 low- and middle-resource geographical regions: Secondary analysis of a cluster randomised controlled trial.

PLoS Med 2019 Mar 29;16(3):e1002775. Epub 2019 Mar 29.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: In 2015, approximately 42,000 women died as a result of hypertensive disorders of pregnancy worldwide; over 99% of these deaths occurred in low- and middle-income countries. The aim of this paper is to describe the incidence and characteristics of eclampsia and related complications from hypertensive disorders of pregnancy across 10 low- and middle-income geographical regions in 8 countries, in relation to magnesium sulfate availability.

Methods And Findings: This is a secondary analysis of a stepped-wedge cluster randomised controlled trial undertaken in sub-Saharan Africa, India, and Haiti. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440614PMC
March 2019
1 Read

Increase in the number of patients diagnosed using the new classification of hypertensive disorders of pregnancy in Japan.

J Obstet Gynaecol Res 2019 Mar 28. Epub 2019 Mar 28.

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Aim: This study aimed to examine how the number of patients diagnosed with pre-eclampsia increased according to the Japanese classification of hypertensive disorders of pregnancy (HDP) that was revised in 2018. The effect of new classification on perinatal outcomes was also analyzed.

Methods: We enrolled 181 women with HDP who delivered at Hokkaido University Hospital between February 2011 and December 2017. Read More

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http://dx.doi.org/10.1111/jog.13955DOI Listing
March 2019
3 Reads

Colostrum of Preeclamptic Women Has a High Level of Polyphenols and Better Resistance to Oxidative Stress in Comparison to That of Healthy Women.

Oxid Med Cell Longev 2019 21;2019:1380605. Epub 2019 Feb 21.

Department of Chemical Engineering, Sami Shamoon College of Engineering, Beer-Sheva, Israel.

Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prevailing cause theory of this complication. Women with preeclampsia suffer from acute oxidative stress and high lipid oxidation in plasma. Read More

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http://dx.doi.org/10.1155/2019/1380605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408988PMC
April 2019
2 Reads

The correlation between AGT gene polymorphism and neonatal hypoxic-ischemic encephalopathy (HIE).

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2194-2199

Department of Disease Control, Zhengzhou University Affiliated Children's Hospital, Henan Children's Hospital Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.

Objective: To explore the correlation between the rs2067853 polymorphism in angiotensinogen (AGT) gene and neonatal hypoxic-ischemic encephalopathy (HIE).

Patients And Methods: A total of 96 neonatal patients with HIE and 123 healthy neonates were selected. General clinical data were collected and TaqMan-MGB probe method was adopted to detect the rs2067853 polymorphism in angiotensinogen (AGT) gene. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17266DOI Listing
March 2019
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Management of Hypertension in the Obese Pregnant Patient.

Curr Hypertens Rep 2019 Mar 26;21(3):24. Epub 2019 Mar 26.

Fetal Medicine Unit, St George's Hospital, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.

Purpose Of Review: To evaluate recent developments in the management of hypertension in obese pregnant women.

Recent Findings: The mainstay of management targets prevention of hypertension with preconception counselling, entering pregnancy with a lower BMI, limiting weight gain, and taking low-dose aspirin to prevent pre-eclampsia from before 16 weeks' gestation. There are conflicting results regarding the use of metformin in reducing hypertensive disease, but there is a high probability that it has a role to play. Read More

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http://dx.doi.org/10.1007/s11906-019-0927-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435623PMC
March 2019
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SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression.

Malays J Med Sci 2019 Jan 28;26(1):66-72. Epub 2019 Feb 28.

Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: An imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL1 levels in late-onset PE. Read More

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http://dx.doi.org/10.21315/mjms2019.26.1.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419870PMC
January 2019
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Abdelazim and AbuFaza ELLP syndrome as a variant of HELLP syndrome: Case reports.

J Family Med Prim Care 2019 Jan;8(1):280-284

Department of Obstetrics and Gynecology, Ahmadi Hospital, Kuwait Oil Company, Ahmadi, Kuwait.

Background: The hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a serious complication in pregnancy occurring in 0.5-0.9% of all pregnancies and in 10-20% of cases with severe pre-eclampsia. Read More

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http://www.jfmpc.com/text.asp?2019/8/1/280/251176
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http://dx.doi.org/10.4103/jfmpc.jfmpc_381_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396606PMC
January 2019
3 Reads

Effects of central obesity on maternal complications in Korean women of reproductive age.

Obes Res Clin Pract 2019 Mar - Apr;13(2):156-163. Epub 2019 Mar 22.

Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea. Electronic address:

Background: Considering the obesity-related complications in pregnancy and during delivery, prepregnancy central obesity may also affect pregnancy-related complications. This study aimed to assess the relationship between prepregnancy central obesity and adverse maternal outcomes in Korean women, by using the Korean National Health Insurance Service (NHIS) cohort.

Methods: In this population-based retrospective cohort study, we used data from the NHIS database, which contains information of health-care utilisation, diagnosis and prescription, and mortality for almost the whole Korean population, together with data from the NHIS health checkup database from 2005 to 2015. Read More

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http://dx.doi.org/10.1016/j.orcp.2019.03.004DOI Listing
March 2019
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Maternal serum uric acid and calcium as predictors of hypertensive disorder of pregnancy: A case control study.

Taiwan J Obstet Gynecol 2019 Mar;58(2):244-250

Department of Physiology, U.P. University of Medical Sciences, House No. 168, Kaveri Kunj, Phase II, Kamla Nagar, Saifai, Etawah, Agra, 282005, Uttar Pradesh, India. Electronic address:

Objectives: Compare serum uric acid and calcium levels among normotensive and hypertensive pregnant women, to compare maternal and perinatal outcomes in two groups.

Materials And Methods: Prospective case control study was conducted after ethical approval in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India, over seven months. Total 220 antenatal women ≥34 weeks of gestation with 110 cases having hypertensive disorder of pregnancy and 110 controls with normal blood pressure were compared for maternal uric acid and calcium levels and maternal, perinatal outcomes. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.014DOI Listing
March 2019
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Analysis of 62 placental abruption cases: Risk factors and clinical outcomes.

Taiwan J Obstet Gynecol 2019 Mar;58(2):223-226

Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

Objective: This study aimed to explore the clinical characteristics and outcomes of placental abruption.

Materials And Methods: A total of 62 placental abruption cases were collected from the Second Hospital of Jilin University between January 2007 and December 2012. A retrospective study was conducted to explore the risk factors for placental abruption, clinical characteristics, and maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.010DOI Listing
March 2019
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Serum anti mullerian hormone and renalase levels in predicting the risk of preeclampsia.

Taiwan J Obstet Gynecol 2019 Mar;58(2):188-191

Department of Biological & Biomedical Sciences, Aga Khan University, Pakistan. Electronic address:

Objective: The aim of the study was to explore the association of serum AMH and Renalase with the risk of preeclampsia thereby assessing them as screening tools, reducing the risk of gravid consequences of preeclampsia.

Materials And Methods: This cross-sectional study recruited n = 95 pregnant women between 14 and 32 gestational weeks. They were categorized as a) women with gestational hypertension (n = 45); b) women with pre-eclampsia (n = 20) and c) normotensive pregnant women (n = 30) according to the ACOG criteria. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.01.003DOI Listing
March 2019
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In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines.

J Vis Exp 2019 Mar 5(145). Epub 2019 Mar 5.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine;

Cell movement is a critical property of trophoblasts during placental development and early pregnancy. The significance of proper trophoblast migration and invasion is demonstrated by pregnancy disorders such as pre-eclampsia and intrauterine growth restriction, which are associated with inadequate trophoblast invasion of the maternal vasculature. Unfortunately, our understanding of the mechanisms by which the placenta develops from migrating trophoblasts is limited. Read More

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http://dx.doi.org/10.3791/58942DOI Listing
March 2019
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Clinical Characteristics of Pregnant Women on the Use of Daily Low-dose Aspirin in Different Hypertensive Pregnancy Disorders: A Retrospective Comparative Study.

J Pharm Bioallied Sci 2019 Jan-Mar;11(1):77-82

Clinical Laboratory Sciences Department, College of Pharmacy, Mustansiriya University, Baghdad-IRAQ.

Background: Hypertensive disorders represent major causes of maternal and fetal complications. It includes a range of conditions, most notably preeclampsia. Aspirin is a well-accepted therapy for the primary and secondary prevention of cardiovascular events. Read More

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http://dx.doi.org/10.4103/jpbs.JPBS_183_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394152PMC
March 2019
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Posterior reversible encephalopathy syndrome associated with reversible cerebral vasoconstriction syndrome in a patient presenting with postpartum eclampsia: A case report.

J Gynecol Obstet Hum Reprod 2019 Mar 21. Epub 2019 Mar 21.

Department of Gynecology, obstetrics and reproductive medicine, Foch Hospital, Suresnes 92150, France.

Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction (RCVS) are rare neurological disorders with complex physiopathology which is not yet fully understood. We present here the case of a 31-year-old woman with a bi-amniotic bi-chorial pregnancy who developed immediate postpartum eclampsia after vaginal delivery, associated with RCVS and PRES. Although post-partum is a well-known precipitating factors for these diseases, to our knowledge, there are only few similar cases reported with the association of these syndromes. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.03.019DOI Listing
March 2019
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Effect of stretching exercises versus autogenic training on preeclampsia.

J Exerc Rehabil 2019 Feb 25;15(1):109-113. Epub 2019 Feb 25.

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Preeclampsia (PE) is the most common medical complication of pregnancy characterized by hypertension and significant proteinuria after the 20th week of gestation, its prevalence is about 2%-8% of pregnancies. Antihypertensive drugs were found to have an adverse effect to both the mother and the fetus so interest is increased in nonchemical treatment. This study was conducted to compare between the effects of stretching exercises versus autogenic training (AT) on PE. Read More

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http://dx.doi.org/10.12965/jer.1836524.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416512PMC
February 2019
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Association between RUNX3 gene polymorphisms in severe preeclampsia and its clinical features.

Medicine (Baltimore) 2019 Mar;98(12):e14954

Department of Obstetrics and Gynecology.

Preeclampsia is a complex genetic disorder and its pathogenesis remains to be investigated. Single nucleotide polymorphisms serve important roles in genetic predisposition. The present study aimed to explore the association between runt-related transcription factor 3 (RUNX3) gene polymorphisms in severe preeclampsia (SPE) and clinical features. Read More

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http://dx.doi.org/10.1097/MD.0000000000014954DOI Listing