399,830 results match your criteria Pregnancy Diagnosis


Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Horm Metab Res 2019 Apr 25;51(4):230-242. Epub 2019 Apr 25.

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1. Read More

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http://dx.doi.org/10.1055/a-0863-5779DOI Listing

Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review.

JBI Database System Rev Implement Rep 2019 Apr 23. Epub 2019 Apr 23.

School of Nursing, University of Mississippi Medical Center, Jackson, USA.

Objective: The objective of this review was to determine if there was an association between maternal exposure to pollutant particulate matter 2.5 during the first trimester of pregnancy and congenital heart defects within the first year of life.

Introduction: The environment is recognized as an important determinant of health for both the individual and population. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003881DOI Listing

Autoantibodies, elevated cytokines, and neurocognitive abnormalities in offspring of women with systemic lupus erythematosus: comparison with healthy controls.

Clin Rheumatol 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Medicine and Health Sciences, University of Barcelona, c/ Villarroel 170, 08036, Barcelona, Spain.

Introduction: Research describes higher incidence of neurodevelopmental disorders and learning disabilities in offspring of women affected by lupus. Factors implied are pregnancy and delivery adversities and exposure to maternal antibodies and cytokines. Little is known about the offspring immunological condition or the relation between offspring and maternal condition. Read More

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http://dx.doi.org/10.1007/s10067-019-04495-4DOI Listing

Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome.

Case Rep Obstet Gynecol 2019 25;2019:4325647. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. We report a patient diagnosed with severe vitamin B12 deficiency, following termination of pregnancy for suspected preeclampsia and HELLP syndrome at 21 weeks' gestation. When hemolysis and thrombocytopenia persisted after delivery, testing was performed to rule out other etiologies of thrombotic microangiopathy, including atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and vitamin B12 deficiency. Read More

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http://dx.doi.org/10.1155/2019/4325647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452556PMC

What's Happening When the Pregnancies Are Not Terminated in Case of Anencephalic Fetuses?

J Clin Med Res 2019 May 14;11(5):332-336. Epub 2019 Apr 14.

Department of Obstetrics and Gynecology, Ataturk Education and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.

Background: To review the obstetric outcomes of pregnancies with anencephalic fetuses when these pregnancies are not terminated and ongoing.

Methods: A retrospective chart review is made of the cases with a prenatal diagnosis of anencephaly and who were opted to continue the pregnancy in 1-year period. The evaluated data included gestational age at diagnosis, gestational age at birth, labor induction rates, cesarean delivery rates, stillbirth, shoulder dystocia rate, antepartum and postpartum hemorrhage. Read More

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http://dx.doi.org/10.14740/jocmr3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469884PMC

Breast Ultrasound during Lactation: Benign and Malignant Lesions.

Breast Care (Basel) 2019 Mar 12;14(1):30-34. Epub 2018 Oct 12.

Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.

Background: Structural changes during lactation make breast physical examination difficult. When breast problems occur, patients are often referred for an ultrasound (US) scan. Most breast lesions diagnosed in these patients are benign, but the diagnosis of breast cancer is a challenge. Read More

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http://dx.doi.org/10.1159/000491781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465775PMC

Glycemic and metabolic features in gestational diabetes: singleton versus twin pregnancies.

Endocr J 2019 Apr 23. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0575DOI Listing

Hurler-Scheie syndrome in Niger: a case series.

J Med Case Rep 2019 Apr 25;13(1):102. Epub 2019 Apr 25.

Department of Neurology, National Hospital of Niamey, PO Box 238, Niamey, Niger.

Background: Hurler-Scheie syndrome is an intermediate form of mucopolysaccharidosis type I which is a rare lysosomal storage disorder caused by the deficiency or complete absence of enzyme alpha-L-iduronidase activity. We report the first documented cases of Hurler-Scheie syndrome observed in Niger in a Touareg family.

Case Presentation: We studied the case of two 12-year-old twin Touareg boys and their 10-year-old Touareg sister whose parents are first-degree cousins, and there was no history of similar cases in their previous generations. Read More

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http://dx.doi.org/10.1186/s13256-019-2047-2DOI Listing

Breaking the News: Parents' Experiences of Receiving an Antenatal Diagnosis of Cleft Lip.

Cleft Palate Craniofac J 2019 Apr 24:1055665619830884. Epub 2019 Apr 24.

1 Centre for Appearance Research, University of the West of England, Bristol, United Kingdom.

Objective: In high-income countries, many cases of cleft lip are now identified at the 18- to 21-week pregnancy scan. The manner in which a diagnosis is communicated is vital for long-term parental well-being, yet previous studies have been indicative of parental dissatisfaction. The aims of the present study were to examine the experiences of parents who received an antenatal diagnosis of cleft lip in their unborn child and to offer pragmatic suggestions for improving the diagnostic experience in practice. Read More

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http://dx.doi.org/10.1177/1055665619830884DOI Listing

Preimplantation Genetic Diagnosis of Neurodegenerative Diseases: Review of Methodologies and Report of Our Experience as a Regional Reference Laboratory.

Diagnostics (Basel) 2019 Apr 23;9(2). Epub 2019 Apr 23.

Department of Neurology, National Taiwan University Hospital, Taipei 10048, Taiwan.

Preimplantation genetic diagnosis (PGD) has become a crucial approach in helping carriers of inherited disorders to give birth to healthy offspring. In this study, we review PGD methodologies and explore the use of amplification refractory mutation system quantitative polymerase chain reaction (ARMS-qPCR) and/or linkage analysis for PGD in neurodegenerative diseases that are clinically relevant with typical features, such as late onset, and which are severely debilitating. A total of 13 oocyte retrieval cycles were conducted in 10 cases with various neurodegenerative diseases. Read More

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http://dx.doi.org/10.3390/diagnostics9020044DOI Listing

"Real life" use of raltegravir during pregnancy in France: The Coferal-IMEA048 cohort study.

PLoS One 2019 24;14(4):e0216010. Epub 2019 Apr 24.

INSERM IAME UMR-S 1137, Université Paris Diderot, Paris, France.

Introduction: Limited "real life" data on raltegravir (RAL) use during pregnancy are available. Thus, we aimed at describing effectiveness and safety of RAL-based combined antiretroviral therapy (cART) in this setting.

Methods: HIV-1-infected women receiving RAL during pregnancy between 2008 and 2014 in ten French centers were retrospectively analysed for: (1) proportion of women receiving RAL anytime during pregnancy who achieved a plasma HIV-RNA (pVL) < 50 copies/mL at delivery, and (2) description of demographics, immuno-virological parameters and safety in women and new-borns. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216010PLOS

Low rate of early vertical transmission of HIV supports the feasibility of effective implementation of the national PMTCT guidelines in routine practice of referral hospitals in Cameroon.

Paediatr Int Child Health 2019 Apr 24:1-8. Epub 2019 Apr 24.

l Assistance Publique des Hôpitaux de Paris, Pédiatrie Générale , Hôpital Robert Debré , Paris , France.

Background: Vertical (VT) transmission of HIV remains a public health concern in sub-Saharan Africa.

Objective: To investigate the VT rate and factors associated with transmission in routine practice in three referral hospitals in Cameroon.

Methods: All HIV-infected mothers who delivered in maternity wards or sought paediatric services during the first postnatal week from November 2007 to October 2010 were invited to participate in the ANRS-Pediacam cohort. Read More

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http://dx.doi.org/10.1080/20469047.2019.1585136DOI Listing

Evaluation and Management of Congenital Chagas Disease in the United States.

J Pediatric Infect Dis Soc 2019 Apr 24. Epub 2019 Apr 24.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. Read More

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http://dx.doi.org/10.1093/jpids/piz018DOI Listing

A Case of Dubin-Johnson Syndrome in Pregnancy.

Cureus 2019 Feb 11;11(2):e4048. Epub 2019 Feb 11.

Obstetrics & Gynecology, Maulana Azad Medical College, New Delhi, IND.

Dubin-Johnson syndrome is an autosomal recessive condition characterized by recurrent episodes of jaundice and conjugated hyperbilirubinemia. It exacerbates during pregnancy and needs to be differentiated from other causes of jaundice. A 30-year-old patient presented to us with jaundice in her fourth pregnancy. Read More

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http://dx.doi.org/10.7759/cureus.4048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464460PMC
February 2019

Equine Welfare in Practice: A Collaborative Outreach and Education Program with Michigan State University, Universidad Nacional Autónoma de México, and Universidad Veracruzana.

Animals (Basel) 2019 Apr 13;9(4). Epub 2019 Apr 13.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad Universitaria, D.F. México C.P. 04501, Mexico.

There is great need for veterinary care for working equids worldwide. Addressing this need provides an opportunity for veterinary students to gain primary care experience. An annual two week collaborative outreach and educational program with Michigan State University (MSU), the Universidad Nacional Autónoma de México (UNAM) and the Universidad Veracruzana (UV) was developed to provide care for working equids in rural Mexican communities. Read More

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http://dx.doi.org/10.3390/ani9040164DOI Listing

Diagnosing and treating antiphospholipid syndrome: a consensus paper.

Neth J Med 2019 Apr;77(3):98-108

Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, the Netherlands.

Introduction: The antiphospholipid syndrome (APS) is defined by the occurrence of venous and/or arterial thrombosis and/or pregnancy-related morbidity, combined with the presence of antiphospholipid antibodies (aPL) and/or a lupus anticoagulant (LAC). Large, controlled, intervention trials in APS are limited. This paper aims to provide clinicians with an expert consensus on the management of APS. Read More

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Prepregnancy Habitual Intakes of Total, Supplemental, and Food Folate and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.

Diabetes Care 2019 Apr 22. Epub 2019 Apr 22.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD

Objective: To identify novel modifiable risk factors of gestational diabetes mellitus (GDM) by examining the association between prepregnancy habitual folate intake and GDM risk.

Research Design And Methods: The study included 14,553 women in the Nurses' Health Study II who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Prepregnancy intakes of total folate, supplemental folate, and food folate were assessed using a food frequency questionnaire administered every 4 years. Read More

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http://dx.doi.org/10.2337/dc18-2198DOI Listing

Safety of Psychotropic Medications During Pregnancy.

Clin Perinatol 2019 Jun 28;46(2):215-234. Epub 2019 Mar 28.

Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital Center for Women's Mental Health, Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA.

Risks, benefits, alternatives, and appropriateness of psychotropic medications, including risks of no treatment, are discussed for antidepressants, mood-stabilizing medications, anxiolytic/sedative hypnotic medications, stimulants, and medication-assisted treatment of substance use disorders. Early screening, diagnosis, and intervention prior to and/or during pregnancy often reduce morbidity and mortality of mental health disorders for mothers and infants. Read More

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http://dx.doi.org/10.1016/j.clp.2019.02.004DOI Listing

The pivotal role of betaHCG levels in the diagnosis and management of heterotopic twin pregnancy, a rare and life threatening high-risk condition.

J Obstet Gynaecol 2019 Apr 22:1-2. Epub 2019 Apr 22.

a Department of Obstetrics , Foundation MBBM, School of Medicine and Surgery, University of Milan-Bicocca , Monza , Monza e Brianza , Italy.

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http://dx.doi.org/10.1080/01443615.2019.1571568DOI Listing

European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - Endorsed by the European Academy of Neurology.

Eur Stroke J 2017 Sep 21;2(3):195-221. Epub 2017 Jul 21.

Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.

The current proposal for cerebral venous thrombosis guideline followed the Grading of Recommendations, Assessment, Development, and Evaluation system, formulating relevant diagnostic and treatment questions, performing systematic reviews of all available evidence and writing recommendations and deciding on their strength on an explicit and transparent manner, based on the quality of available scientific evidence. The guideline addresses both diagnostic and therapeutic topics. We suggest using magnetic resonance or computed tomography angiography for confirming the diagnosis of cerebral venous thrombosis and not screening patients with cerebral venous thrombosis routinely for thrombophilia or cancer. Read More

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http://journals.sagepub.com/doi/10.1177/2396987317719364
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http://dx.doi.org/10.1177/2396987317719364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454824PMC
September 2017
1 Read

Arterial and venous complications after fertility treatment: A French nationwide cohort study.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.02.034DOI Listing
March 2019
3 Reads

First trimester Doppler velocimetry of the uterine artery ipsilateral to the placenta improves ability to predict early-onset preeclampsia.

Medicine (Baltimore) 2019 Apr;98(16):e15193

Department of Statistics, University of Connecticut, Storrs, CT.

This study sought to investigate the effects of placental laterality on the measurements of uterine artery (UtA) Doppler velocimetry and their application in predicting early-onset preeclampsia (PE).We conducted a prospective cohort study on all women with singleton, uncomplicated pregnancies scheduled for first-trimester nuchal translucency at our institution. Pulsatility index (PI) for both UtAs was measured by Doppler velocimetry, and placental laterality was determined. Read More

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http://dx.doi.org/10.1097/MD.0000000000015193DOI Listing

Management of stroke and pregnancy.

Eur Stroke J 2018 Sep 12;3(3):227-236. Epub 2018 Apr 12.

Obstetrics, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Stroke continues to be one of the main causes of death in the developed countries and the incidence in pregnancy appears to be increasing. Pregnancy-related stroke has a relatively high mortality rate of 10% and so clinicians need to be mindful of appropriate investigations and referral of a pregnant woman with suspected stroke, so they can receive timely treatment. In this review we address the risk factors associated with stroke, diagnosis and appropriate management of the different stroke types. Read More

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http://dx.doi.org/10.1177/2396987318769547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453206PMC
September 2018

A 7-year follow-up of antenatal depression treatment with cognitive behavioral therapy: A case report of maternal and child outcomes.

SAGE Open Med Case Rep 2019 9;7:2050313X19841463. Epub 2019 Apr 9.

Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

There are few studies of cognitive behavioral therapy for women with antenatal depression including qualitative and quantitative data, and yet, individual cases can provide valuable information on personal experiences of treatment effectiveness and acceptability. The purpose of this case report is to explore the long-term qualitative outcomes following cognitive behavioral therapy for antenatal depression. A pregnant woman with a Diagnostic and Statistical Manual of Mental Disorders diagnosis of depression was allocated to receive seven sessions of cognitive behavioral therapy in a randomized controlled trial. Read More

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http://dx.doi.org/10.1177/2050313X19841463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457020PMC

Cesarean scar ectopic pregnancy: Case report.

Radiol Case Rep 2019 Mar 2;14(3):354-359. Epub 2019 Feb 2.

University of North Carolina, Department of Obstetrics and Gynecology, Maternal Fetal Medicine, 3010 Old Clinic CB # 7516, Chapel Hill, NC 27599.

Cesarean scar ectopic pregnancies are a rare form of extrauterine pregnancies, yet their incidence is increasing given the rise in cesarean deliveries. Similar to other ectopic pregnancies, cesarean scar ectopic pregnancies pose a great risk for maternal hemorrhage and ultimately maternal mortality. This study presents the case of a cesarean scar ectopic pregnancy in a patient with 3 prior cesarean deliveries. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457063PMC

Post-traumatic stress disorder and hypertensive disorders of pregnancy among military women.

Paediatr Perinat Epidemiol 2019 Apr 21. Epub 2019 Apr 21.

College of Public Health, University of South Florida, Tampa, Florida.

Background: Women are more likely to develop post-traumatic stress disorder (PTSD) than men. Limited research exists evaluating the risk of hypertensive disorders of pregnancy (HDP) among military women with PTSD.

Methods: We conducted a retrospective cohort study using US Department of Defense (DoD) data comprised of all active-duty women giving birth to their first, liveborn singleton infant using DoD-sponsored health insurance from 1 January 2004 to 31 December 2008 (n = 34 176). Read More

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http://dx.doi.org/10.1111/ppe.12546DOI Listing

A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
1 Read

Uterine Artery Embolization and Methotrexate Infusion as Sole Management for Caesarean Scar and Cervical Ectopic Pregnancies: A Single-Center Experience and Literature Review.

Can Assoc Radiol J 2019 Apr 17. Epub 2019 Apr 17.

Diagnostic and Interventional Radiology Department, Mansoura University, Mansoura, Egypt.

Introduction: The incidence of caesarean scar pregnancy (CSP) and cervical pregnancy (CP) has increased significantly in recent years. The related hemorrhage can be lethal and often needs hysterectomy. This study aims to assess the technical and clinical results of uterine artery embolization (UAE) combined with intra-arterial methotrexate (MTX) infusion for CSP and CP. Read More

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http://dx.doi.org/10.1016/j.carj.2018.12.002DOI Listing

The effect of growth rate on reproductive outcomes in replacement dairy heifers in seasonally calving, pasture-based systems.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

University College Dublin, Belfield, Dublin 4, Ireland D04V1W8.

The effect of average daily gain (ADG) on reproductive outcomes in replacement dairy heifers was investigated. All heifers were managed in the typical Irish spring calving, pasture-based system, where the herd calves in 1 block between January and April and the majority of the diet comprises grazed grass. Heifer calves (n = 399) from 7 herds were weighed at birth and at the beginning of the breeding season, and ADG was calculated. Read More

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http://dx.doi.org/10.3168/jds.2018-16079DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Prenatal diagnosis of fetal isolated right coronary artery to left ventricle fistula.

Echocardiography 2019 Apr 19. Epub 2019 Apr 19.

Department of Sonography, Shengjing Hospital of China Medical University, Shenyang, China.

Coronary artery fistula (CAF) is a rare malformation and is seldom reported during pregnancy. Right coronary artery fistula commonly drains into the right ventricle, right atrium, or pulmonary artery. We describe here a rare case of fetal CAF draining into the left ventricle using cross-sectional and color Doppler echocardiography. Read More

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http://dx.doi.org/10.1111/echo.14340DOI Listing
April 2019
3 Reads

Etiologic and Clinical Features of Cerebral Venous Sinus Thrombosis in Saudi Arabia.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):278-282

Department of Medicine, Division of Neurology, 7-112L Clinical Sciences Building, University of Alberta, Edmonton, Canada.

Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST.

Materials And Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis.

Results: There were 15 females while 11 males with a female:male ratio of 1. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/2/278/254
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http://dx.doi.org/10.4103/jnrp.jnrp_305_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454937PMC
April 2019
3 Reads

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality.

Geburtshilfe Frauenheilkd 2019 Apr 26;79(4):382-388. Epub 2019 Feb 26.

Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Hyperemesis gravidarum, severe nausea and vomiting in pregnancy, occurs in up to 2% of pregnancies and leads to significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity. Familial aggregation studies and twin studies suggest a genetic component. Read More

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http://dx.doi.org/10.1055/a-0830-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461465PMC

Pituitary Disease in Pregnancy: Special Aspects of Diagnosis and Treatment?

Geburtshilfe Frauenheilkd 2019 Apr 6;79(4):365-374. Epub 2019 Mar 6.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany.

The diagnosis and treatment of pituitary disease in pregnancy represents a special clinical challenge. Not least because there is very little data on the treatment of pregnant patients with pituitary disorders. A selective search of the literature was carried out with the aim of compiling evidence about the diagnosis and treatment of pituitary disease in pregnancy. Read More

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http://dx.doi.org/10.1055/a-0794-7587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461462PMC
April 2019
1 Read

Tuberculosis in Pregnancy - a Summary.

Geburtshilfe Frauenheilkd 2019 Apr 8;79(4):358-365. Epub 2019 Jan 8.

Abteilung für Geburtsmedizin, Universitätsfrauenklinik Leipzig, Universitätsklinikum Leipzig AöR, Leipzig, Germany.

In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be assumed due to the migratory flows; current data from the USA, for example, also show an increasing incidence of tuberculosis in pregnant women in recent years. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0774-7924
Publisher Site
http://dx.doi.org/10.1055/a-0774-7924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461468PMC
April 2019
1 Read

Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial.

Lancet Glob Health 2019 May;7(5):e664-e670

Division of Infectious Diseases, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Dengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30032-4DOI Listing

Analysis of preventability of malignancy related maternal death from the nationwide registration syste19m of maternal deaths in Japan.

J Matern Fetal Neonatal Med 2019 Apr 18:1-191. Epub 2019 Apr 18.

b Department of Obstetrics and Gynecology , Mie University School of Medicine , Mie , Japan.

Objective: We reviewed malignancy related maternal deaths in Japan to ascertain if there were avoidable factors.

Methods: Malignancy related maternal death in Japan reported to the Maternal Death Exploratory Committee, from 2010 to 2016 inclusive.

Results: There were 12 cases of maternal death caused by malignancy. Read More

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http://dx.doi.org/10.1080/14767058.2019.1609930DOI Listing
April 2019
2 Reads

Termination of pregnancy for foetal anomalies: parents' preferences for psychosocial care.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Child and Adolescent Psychiatry/Psychology, Unit of Psychosocial Care, Erasmus Medical Center and Sophia Children's Hospital, Rotterdam, The Netherlands.

Objective: To investigate, from the perspective of women and partners, at what stage of a termination of pregnancy (TOP) for foetal anomalies psychosocial care (PSC) is most meaningful, what topics should be discussed, and who should provide PSC.

Method: A cross-sectional retrospective cohort study was conducted with a consecutive series of 76 women and 36 partners, who completed a semi-structured online questionnaire.

Results: Overall, women expressed a greater need for PSC than their partners. Read More

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http://dx.doi.org/10.1002/pd.5464DOI Listing
April 2019
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Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

J Cancer Surviv 2019 Apr 17;13(2):269-281. Epub 2019 Apr 17.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.

Purpose: Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. Read More

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http://link.springer.com/10.1007/s11764-019-00749-x
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http://dx.doi.org/10.1007/s11764-019-00749-xDOI Listing
April 2019
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Pregnancy rate and outcome of pregnancies in long-term survivors of Hodgkin's lymphoma.

Ann Hematol 2019 Apr 17. Epub 2019 Apr 17.

Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy.

Thanks to the increased number of young survivors of Hodgkin's lymphoma (HL), management of the pregnancies of women who have a history of exposure to chemotherapies and radiation therapy is becoming increasingly common. Many patients and clinicians are worried that pregnancy after the diagnosis of HL may increase the risk of relapse, despite a lack of empirical evidence to support such concerns. In the present study, we included 89 women diagnosed with HL between 2006 and 2015 under the age of 50 years, who were in complete remission and alive without relapse > 1 year after treatment. Read More

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http://dx.doi.org/10.1007/s00277-019-03684-0DOI Listing
April 2019
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Heterotopic pregnancy with suspicion of superfetation after the intrauterine insemination cycle with ovulation induction using clomiphene citrate: A case report.

Clin Pract 2019 Jan 25;9(1):1129. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, Ageo Central General Hospital, Ageo-shi, Saitama-ken.

At 22 days after intrauterine insemination with ovulation induction using clomiphene citrate at a previous hospital, a 30-year-old woman was admitted to our hospital owing to right lower quadrant abdominal pain. We diagnosed threatened abortion because of a gestational sac in the uterus on transvaginal ultrasonography. The next day, she complained of increased abdominal pain. Read More

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http://dx.doi.org/10.4081/cp.2019.1129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444374PMC
January 2019
2 Reads

Early infection with cytomegalovirus and risk of childhood hematological malignancies.

Cancer Epidemiol Biomarkers Prev 2019 Apr 17. Epub 2019 Apr 17.

Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institute.

Background: Congenital cytomegalovirus (CMV) infection was recently identified as a risk factor for childhood acute lymphocytic leukemia by detecting the presence of CMV sequences in neonatal blood spots. In the current study, we asked whether clinically apparent CMV infection could be identified prior to hematological malignancy, using high quality Swedish population-based registries.

Methods: CMV infection was identified with appropriate ICD-9 or ICD-10 codes in the Patient and Medical Birth Registries, and childhood malignancies below the age of 15 were identified in the Cancer Registry, among 2,782,507 children born in Sweden 1987 to 2014. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0044DOI Listing
April 2019
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MATERNAL THYROID-STIMULATING HORMONE LEVEL IN THE FIRST TRIMESTER AND SEX RATIO AT BIRTH.

Endocr Pract 2019 Apr;25(4):315-319

Few studies have explored the influence of thyroid status on sex ratio at birth, and conclusions are inconsistent. The aim of this study was to determine if there is an association between serum thyroid-stimulating hormone (TSH) level in first trimester and sex ratio at birth. The study was a retrospective cohort study performed at a tertiary care center. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0348
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http://dx.doi.org/10.4158/EP-2018-0348DOI Listing
April 2019
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Metabolic Fingerprinting of Chorionic Villous Samples in Normal Pregnancy and Chromosomal Disorders.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico A.Cao, Cagliari, Italy.

Objective: Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Read More

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http://dx.doi.org/10.1002/pd.5461DOI Listing

Cardiovascular Disease: Lower Extremity Deep Venous Thrombosis.

FP Essent 2019 Apr;479:21-29

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Risk factors for deep venous thrombosis (DVT) include immobility, recent or current hospitalization, recent surgery, recent infection, and cancer. Patients with suspected venous thromboembolism should be evaluated with the Wells score or modified Wells score (which adds a previous DVT) to determine the likelihood of DVT. A low or moderate probability score and a normal D-dimer test result exclude DVT. Read More

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April 2019
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Congenital toxoplasmosis: the challenge of early diagnosis of a complex and neglected disease.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180228. Epub 2019 Apr 11.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brasil.

The objective of this study was to report a case of congenital toxoplasmosis that illustrates the difficulties in diagnosing this disease. The case highlights the lack of prophylactic guidelines and shortcomings in the gestational screening process. It demonstrates the peculiarities of the non-specific clinical picture of the infection acquired during pregnancy and identifies the challenges of ophthalmological and high-sensitivity exams in newborns that are crucial for an early diagnosis. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0228-2018DOI Listing
April 2019
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A case of incidental endometrial adenocarcinoma diagnosed in early pregnancy and managed conservatively.

Gynecol Oncol Rep 2019 May 27;28:101-103. Epub 2019 Mar 27.

Department of Gynaecological Oncology, East Suffolk and North Essex NHS Foundation Trust, Ipswich hospital, Suffolk, United Kingdom.

We report a 29-year old nulliparous woman diagnosed with a grade 1 endometrioid adenocarcinoma of the endometrium arising from an atypical polypoid adenomyoma, while being investigated for a suspected threatened miscarriage at 7 weeks gestation. She presented complaining of vaginal bleeding and a small amount of soft tissue in the cervical os was found and sent for histology. An ultrasound scan was performed, which confirmed an intrauterine ongoing pregnancy. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449706PMC
May 2019
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Preferences for aspects of antenatal and newborn screening: a systematic review.

BMC Pregnancy Childbirth 2019 Apr 16;19(1):131. Epub 2019 Apr 16.

Manchester Centre for Health Economics, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: Many countries offer screening programmes to unborn and newborn babies (antenatal and newborn screening) to identify those at risk of certain conditions to aid earlier diagnosis and treatment. Technological advances have stimulated the development of screening programmes to include more conditions, subsequently changing the information required and potential benefit-risk trade-offs driving participation. Quantifying preferences for screening programmes can provide programme commissioners with data to understand potential demand, the drivers of this demand, information provision required to support the programmes and the extent to which preferences differ in a population. Read More

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http://dx.doi.org/10.1186/s12884-019-2278-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469127PMC