141,275 results match your criteria Pregnancy Delivery


Risk of cesarean after induction of labor in twin compared to singleton pregnancies.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 8;237:68-73. Epub 2019 Apr 8.

Port-Royal Maternity Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris (APHP), DHU Risks in pregnancy, Paris-Descartes university, Paris, France; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Centre For Epidemiology and Statistics Sorbonne Paris Cité (CRESS), DHU Risks in pregnancy, Paris-Descartes university, Paris, France.

Objective: To assess the risk of cesarean delivery after induction of labor in twin compared with singleton pregnancies.

Study Design: This retrospective multicenter study compared data from two nationwide prospective cohorts: one of twin pregnancies established from February 2014 through March 2015 (JUMODA cohort), and the other of singleton pregnancies in November and December 2015 (MEDIP cohort). This study includes all women in both cohorts who had labor induced at ≥ 35 weeks of gestation, with a live fetus in cephalic presentation (Twin 1 for the twin pregnancies). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.005DOI Listing

Exposure to carbon black nanoparticles during pregnancy persistently damages the cerebrovascular function in female mice.

Toxicology 2019 Apr 22. Epub 2019 Apr 22.

Department of Occupational and Environmental Health, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Post-doctoral Research Stations of Nursing Science, School of Nursing, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Electronic address:

Maternal exposure to carbon black nanoparticles (CBNPs) during pregnancy have been well documented to induce harmful outcomes of offspring on brain function. However, it remains largely unknown whether females exposed to CBNPs during sensitive period of pregnancy can cause the neurotoxic effects on their own body after parturition. In this study, our results showed that pregnancy CBNPs exposure induced the persistent pathological changes in the cerebral cortex tissues and impaired cerebrovascular function of mice manifested by significant alterations of endothelin-1, endothelial nitric oxide synthase, vascular endothelial growth factor-A and ATP-binding cassette transporter G1. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.014DOI Listing

The performance of pre-delivery serum concentrations of angiogenic factors in predicting postpartum antihypertensive drug therapy following abdominal delivery in severe preeclampsia and normotensive pregnancy.

PLoS One 2019 25;14(4):e0215807. Epub 2019 Apr 25.

Department of Optics and Imaging, University of KwaZulu-Natal, South Africa.

Background: The imbalance between circulating concentrations of anti- and pro-angiogenic factors is usually intense in preeclampsia with severe features (sPE). It is possible that pre-delivery circulating levels of angiogenic factors in sPE may be associated with postpartum antihypertensive drug requirements.

Objective: To determine the predictive association between maternal pre-delivery serum concentrations of angiogenic factors and the use of ≥3 slow- and/or a rapid-acting antihypertensive drug therapy in sPE on postpartum days zero to three following caesarean delivery. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215807PLOS
April 2019
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Maternal Stress and Mental Health Prior to Their Technology-Dependent Infant's Discharge Home From the NICU.

J Perinat Neonatal Nurs 2019 Apr/Jun;33(2):149-159

Frances Payne Bolton School of Nursing (Drs Toly, Musil, and Bieda and Mss Blanchette and Em), and Department of Epidemiology and Biostatistics, School of Medicine (Dr Sattar), Case Western Reserve University, Cleveland, Ohio; and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (Ms Liu).

Mothers of infants in the neonatal intensive care unit (NICU) face stressors including turbulent emotions from their pregnancy/unexpected preterm delivery and their infant's unpredictable health status. The study purpose was to examine the psychological state of mothers prior to the discharge of their technology-dependent infants (eg, feeding tubes, supplemental oxygen) from the NICU to home. The study sample consisted of mothers (N = 19) of infants dependent on medical technology being discharged from a large Midwest NICU. Read More

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http://dx.doi.org/10.1097/JPN.0000000000000409DOI Listing

Development of a Phone Survey Tool to Measure Respectful Maternity Care During Pregnancy and Childbirth in India: Study Protocol.

JMIR Res Protoc 2019 Apr 25;8(4):e12173. Epub 2019 Apr 25.

National Health Systems Resource Center, Delhi, India.

Background: Respectful maternity care (RMC) is a key barometer of the underlying quality of care women receive during pregnancy and childbirth. Efforts to measure RMC have largely been qualitative, although validated quantitative tools are emerging. Available tools have been limited to the measurement of RMC during childbirth and confined to observational and face-to-face survey modes. Read More

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http://dx.doi.org/10.2196/12173DOI Listing

Maternal risk factors for neonatal acidosis in women with type 1 diabetes.

Pol Arch Intern Med 2019 Apr 25. Epub 2019 Apr 25.

INTRODUCTION Type 1 diabetes in the mother is associated with a high risk of adverse neonatal outcomes. OBJECTIVES To identify maternal factors associated with low arterial pH values  (pH< 7.10) in infants of type 1 diabetic mothers. Read More

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http://dx.doi.org/10.20452/pamw.14809DOI Listing

Compliance with screening for and recommended management of maternal group B streptococcus carriage in pregnancy.

Aust N Z J Obstet Gynaecol 2019 Apr 25. Epub 2019 Apr 25.

Department of Microbiology and Infectious Disease, Royal Women's Hospital, Melbourne, Australia.

Background: Universal screening of pregnant women at 35-37 weeks gestation is recommended for detection of anogenital group B streptococcus carriage. Intrapartum chemoprophylaxis is prescribed to carriers to prevent transmission to babies, reducing early-onset neonatal group B streptococcal sepsis.

Aims: To review compliance with, and the effects of education on group B streptococcus screening and intrapartum chemoprophylaxis practices at The Royal Women's Hospital, Melbourne, Australia. Read More

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http://dx.doi.org/10.1111/ajo.12977DOI Listing

Autoantibodies, elevated cytokines, and neurocognitive abnormalities in offspring of women with systemic lupus erythematosus: comparison with healthy controls.

Clin Rheumatol 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Medicine and Health Sciences, University of Barcelona, c/ Villarroel 170, 08036, Barcelona, Spain.

Introduction: Research describes higher incidence of neurodevelopmental disorders and learning disabilities in offspring of women affected by lupus. Factors implied are pregnancy and delivery adversities and exposure to maternal antibodies and cytokines. Little is known about the offspring immunological condition or the relation between offspring and maternal condition. Read More

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http://dx.doi.org/10.1007/s10067-019-04495-4DOI Listing

Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study.

Breast Cancer Res Treat 2019 Apr 24. Epub 2019 Apr 24.

Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University College of Medicine, 25 Simgok-ro 100 beon-gil, Seo-gu, Incheon, 22711, Republic of Korea.

Purpose: Alongside the modern trend of delaying childbirth, the high incidence of breast cancer among young women is causing significant pregnancy-related problems in Korea. We estimated the incidence of childbirth for young Korean breast cancer survivors compared with women who did not have breast cancer using a nationally representative dataset.

Methods: Using a database from the National Health Insurance Service in South Korea, we analyzed 109,680 women who were between 20 and 40 years old between 2007 and 2013. Read More

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http://dx.doi.org/10.1007/s10549-019-05244-6DOI Listing

Breech presentation is associated with lower adolescent tibial bone strength.

Osteoporos Int 2019 Apr 24. Epub 2019 Apr 24.

School of Healthcare Science, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5GD, UK.

We compared bone outcomes in adolescents with breech and cephalic presentation. Tibia bone mineral content, density, periosteal circumference, and cross-sectional moment of inertia were lower in breech presentation, and females with breech presentation had lower hip CSA. These findings suggest that prenatal loading may exert long-lasting influences on skeletal development. Read More

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http://dx.doi.org/10.1007/s00198-019-04945-4DOI Listing

A case report: mechanical mitral valve thrombosis in pregnancy.

Eur Heart J Case Rep 2019 Mar 7;3(1):ytz024. Epub 2019 Mar 7.

Department of Cardiology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, Australia.

Background: Pregnancy in women with mechanical valves has a high risk of both valve thrombosis and bleeding as well as adverse effects on the foetus. There is limited data on achieving optimal anticoagulation in pregnancy and management of valve thrombosis, to achieve a successful foetal outcome, while prioritizing the mother's health. While warfarin may carry a lower risk of valve thrombosis, warfarin is teratogenic in the first trimester and is associated with increased foetal loss throughout the pregnancy. Read More

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http://dx.doi.org/10.1093/ehjcr/ytz024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439395PMC

Massive Amniotic Fluid Aspiration in a Case of Sudden Neonatal Death With Severe Hypoplasia of the Retrotrapezoid/Parafacial Respiratory Group.

Front Pediatr 2019 4;7:116. Epub 2019 Apr 4.

Department of Biomedical, Surgical and Dental Sciences, Lino Rossi Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, University of Milan, Milan, Italy.

We report a case of a baby, who, after pregnancy complicated by maternal Addison's disease and Hashimoto's thyroiditis and natural delivery, unexpectedly presented a cardiorespiratory collapse and died 1 hour after birth without responding to prolonged neonatal resuscitation maneuvers. The cause of death was reliably established by carrying out a forensic postmortem examination. More specifically, the histological examination of the lungs showed the presence of abundant endoalveolar and endobronchial cornea scales caused by absorption of amniotic fluid. Read More

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http://dx.doi.org/10.3389/fped.2019.00116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458245PMC

Cancer-Induced Reprogramming of Host Glucose Metabolism: "Vicious Cycle" Supporting Cancer Progression.

Front Oncol 2019 4;9:218. Epub 2019 Apr 4.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.

Unrestricted cancer growth requires permanent supply of glucose that can be obtained from cancer-mediated reprogramming of glucose metabolism in the cancer-bearing host. The pathological mechanisms by which cancer cells exert their negative influence on host glucose metabolism are largely unknown. This paper proposes a mechanism of metabolic and hormonal changes that may favor glucose delivery to tumor (not host) cells by creating a cancer-host "vicious cycle" whose prolonged action drives cancer progression and promotes host cachexia. Read More

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http://dx.doi.org/10.3389/fonc.2019.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458235PMC

Effects of reviewing childbirth scenarios on choice of delivery type: a randomized controlled trial.

Turk J Obstet Gynecol 2019 Mar 27;16(1):15-22. Epub 2019 Mar 27.

Shahroud University of Medical Sciences, School of Public Health, Department of Epidemiology, Shahroud, Iran.

Objective: The incidence of cesarean section (CS) was estimated as about 48% between 2000 and 2012 in Iran. This study was conducted to assess the effects of reviewing written childbirth scenarios on the selection of delivery method.

Materials And Methods: This randomized controlled trial was conducted in Shohada Women's Hospital in Behshahr, Mazandaran, Iran, from May to December 2015. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2019.92260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463434PMC

Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome.

Case Rep Obstet Gynecol 2019 25;2019:4325647. Epub 2019 Mar 25.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. We report a patient diagnosed with severe vitamin B12 deficiency, following termination of pregnancy for suspected preeclampsia and HELLP syndrome at 21 weeks' gestation. When hemolysis and thrombocytopenia persisted after delivery, testing was performed to rule out other etiologies of thrombotic microangiopathy, including atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and vitamin B12 deficiency. Read More

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http://dx.doi.org/10.1155/2019/4325647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452556PMC

What's Happening When the Pregnancies Are Not Terminated in Case of Anencephalic Fetuses?

J Clin Med Res 2019 May 14;11(5):332-336. Epub 2019 Apr 14.

Department of Obstetrics and Gynecology, Ataturk Education and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.

Background: To review the obstetric outcomes of pregnancies with anencephalic fetuses when these pregnancies are not terminated and ongoing.

Methods: A retrospective chart review is made of the cases with a prenatal diagnosis of anencephaly and who were opted to continue the pregnancy in 1-year period. The evaluated data included gestational age at diagnosis, gestational age at birth, labor induction rates, cesarean delivery rates, stillbirth, shoulder dystocia rate, antepartum and postpartum hemorrhage. Read More

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http://dx.doi.org/10.14740/jocmr3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469884PMC

Impact of childhood burn injuries on breastfeeding: a case report.

Int Breastfeed J 2019 18;14:17. Epub 2019 Apr 18.

3Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak Malaysia.

Background: Pre-pubescent girls with chest burns are at risk of complication associated with scarring and impairment in breast development. This case illustrates how burn injuries in childhood in a first-time mother have affected her in terms of breastfeeding.

Case Presentation: In May 2015, a 20 year old first-time mother at 36 weeks gestation was seen in a district health clinic in Kuching, Sarawak in regards to her ability to breastfeed. Read More

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http://dx.doi.org/10.1186/s13006-019-0210-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472062PMC

Glycemic and metabolic features in gestational diabetes: singleton versus twin pregnancies.

Endocr J 2019 Apr 23. Epub 2019 Apr 23.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0575DOI Listing

Weight gain during pregnancy: Does the antenatal care provider make a difference? A retrospective cohort study.

CMAJ Open 2019 Apr-Jun;7(2):E283-E293. Epub 2019 Apr 23.

Midwifery Education Program (Murray-Davis, Syed), Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; Division of Maternal-Fetal Medicine (Berger, Mawjee), Department of Obstetrics and Gynecology, St. Michael's Hospital, University of Toronto; Division of Maternal-Fetal Medicine (Melamed, Barrett), Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; Better Outcomes Registry & Network (BORN) Ontario (Hasan), Children's Hospital of Eastern Ontario, Ottawa, Ont.; Departments of Medicine (Ray) and Obstetrics and Gynaecology (Ray), St. Michael's Hospital, University of Toronto, Toronto, Ont.; Department of Obstetrics & Gynaecology (Geary), Rotunda Hospital, Dublin, Ireland; Division of Maternal-Fetal Medicine (McDonald), Department of Obstetrics and Gynecology, Department of Radiology (McDonald) and Department of Research Methods, Evidence and Impact (McDonald), McMaster University, Hamilton, Ont.

Background: The primary aim of this study was to examine weight gain during pregnancy and associated adverse outcomes across different types of antenatal health care providers. Our research question examined whether type of antenatal health care provider (family physician, obstetrician, midwife, or family physician plus obstetrician) was associated with differing rates of excess or inadequate weight gain and associated adverse outcomes including being large for gestational age, being small for gestational age, cesarean delivery and preterm birth.

Methods: This retrospective cohort study used data from the Better Outcomes Registry & Network Information System, 2014-2016, for singleton hospital births at 20-42 weeks' gestation in Ontario. Read More

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http://dx.doi.org/10.9778/cmajo.20180116DOI Listing

Hurler-Scheie syndrome in Niger: a case series.

J Med Case Rep 2019 Apr 25;13(1):102. Epub 2019 Apr 25.

Department of Neurology, National Hospital of Niamey, PO Box 238, Niamey, Niger.

Background: Hurler-Scheie syndrome is an intermediate form of mucopolysaccharidosis type I which is a rare lysosomal storage disorder caused by the deficiency or complete absence of enzyme alpha-L-iduronidase activity. We report the first documented cases of Hurler-Scheie syndrome observed in Niger in a Touareg family.

Case Presentation: We studied the case of two 12-year-old twin Touareg boys and their 10-year-old Touareg sister whose parents are first-degree cousins, and there was no history of similar cases in their previous generations. Read More

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http://dx.doi.org/10.1186/s13256-019-2047-2DOI Listing

Quality in perinatal care: applying performance measurement using joint commission on accreditation of healthcare organizations indicators in Italy.

BMC Med Res Methodol 2019 Apr 24;19(1):83. Epub 2019 Apr 24.

Department of Health Sciences, University of Catanzaro "Magna Græcia", Via Tommaso Campanella, 88100, Catanzaro, Italy.

Background: Maternal and child health are internationally considered to be among the best measures for assessing health-care quality. The study was carried out with the following aims: 1) to assess the quality of perinatal care (PC) by measuring the frequencies of the five PC indicators developed by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) and comparing results with international standards; 2) to examine whether maternal, pregnancy care and neonatal characteristics could be factors associated with the quality of perinatal care hospital performance, measured through these indicators.

Methods: We retrospectively reviewed medical charts of women over the age of 18 who experienced delivery in Gynecology/obstetrics wards between January-December 2016, and those of their newborns hospitalized in the Neonatology or Neonatal Intensive Care Unit (NICU) of a public non-teaching hospital in Catanzaro (Italy). Read More

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http://dx.doi.org/10.1186/s12874-019-0722-zDOI Listing

Two Birds with One Stone: Health Care Providers' Perspectives about Prevention Technologies in Kenya and South Africa.

J Int Assoc Provid AIDS Care 2019 Jan-Dec;18:2325958219841366

2 RTI International, Women's Global Health Imperative (WGHI), San Francisco, CA, USA.

To meet the reproductive health needs of women, especially those in sub-Saharan Africa, multipurpose prevention technologies (MPTs) that combine pregnancy and HIV prevention into a single product could be highly beneficial. This qualitative study with health care providers in Kenya and South Africa examined health system factors that may facilitate or inhibit the delivery of these MPTs. Twelve qualitative interviews were conducted with health care providers at each site (24 interviews total). Read More

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http://dx.doi.org/10.1177/2325958219841366DOI Listing

Pregnancy Induces an Earlier Chronotype in Both Mice and Women.

J Biol Rhythms 2019 Apr 24:748730419844650. Epub 2019 Apr 24.

Department of Biology, Washington University, St. Louis, MO, USA.

Daily rhythms generated by endogenous circadian mechanisms and synchronized to the light-dark cycle have been implicated in the timing of birth in a wide variety of species. Although chronodisruption (e.g. Read More

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http://dx.doi.org/10.1177/0748730419844650DOI Listing

Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Endocrinology Unit of University Hospital, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective:  Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population.

Methods:  A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687860
Publisher Site
http://dx.doi.org/10.1055/s-0039-1687860DOI Listing
April 2019
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"Real life" use of raltegravir during pregnancy in France: The Coferal-IMEA048 cohort study.

PLoS One 2019 24;14(4):e0216010. Epub 2019 Apr 24.

INSERM IAME UMR-S 1137, Université Paris Diderot, Paris, France.

Introduction: Limited "real life" data on raltegravir (RAL) use during pregnancy are available. Thus, we aimed at describing effectiveness and safety of RAL-based combined antiretroviral therapy (cART) in this setting.

Methods: HIV-1-infected women receiving RAL during pregnancy between 2008 and 2014 in ten French centers were retrospectively analysed for: (1) proportion of women receiving RAL anytime during pregnancy who achieved a plasma HIV-RNA (pVL) < 50 copies/mL at delivery, and (2) description of demographics, immuno-virological parameters and safety in women and new-borns. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216010PLOS

Outcomes of Liver Transplantation for Acute Fatty Liver Disease of Pregnancy.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

University of California, San Francisco, San Francisco, California.

Acute fatty liver of pregnancy (AFLP) often resolves after pregnancy delivery but can progress to acute liver failure necessitating liver transplantation. We performed a retrospective review of the national Scientific Registry of Transplant Recipients (SRTR) data to identify all women in the United States undergoing liver transplantation (LT) for acute liver failure (ALF) from AFLP from 1991 to 2015, and compared to outcomes in women of childbearing age undergoing transplant for ALF from acetaminophen and ALF from other etiologies. Women with AFLP were likely to be on life support at time of LT and had high rates of renal dysfunction (median Cr 2. Read More

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http://dx.doi.org/10.1111/ajt.15401DOI Listing

Trends in obstetric policies in cases of failed vacuum extraction in Japan.

J Matern Fetal Neonatal Med 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Obstetrics and Gynecology , Japanese Red Cross Katsushika Maternity Hospital , Tokyo.

Objective: In April 2008, the guidelines for obstetric practice in Japan have made the following recommendations: (1) do not use vacuum extraction (VE) for more than 20 minutes, and consider forceps delivery (FD) or an emergency cesarean section (CS) if necessary (20-minute VE trial rule), and (2) do not try VE more than 5 times, even if VE has been used for less than 20 minutes (5-time VE trial rule). The aims of the present study were to compare the obstetric policies related to failed VE before and after 2008.

Methods: We reviewed the obstetric records of all cases of VE in cases of singleton pregnancy with a neonatal birth weight ≥ 2500 g beyond 37 weeks' gestation at our hospital from April 2002 to March 2014. Read More

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http://dx.doi.org/10.1080/14767058.2019.1611767DOI Listing

The management of severe pre-eclampsia and HELLP syndrome in a twin pregnancy with a known morbidly adherent placenta: A case report.

Case Rep Womens Health 2019 Apr 11;22:e00114. Epub 2019 Apr 11.

Department of Women's and Newborn Health, Westmead Hospital, Sydney, Australia.

Introduction: Morbidly adherent placenta (MAP) is a rare obstetric complication, especially in cases of multiple gestation. We present a case of MAP complicating a dichorionic diamniotic (DCDA) twin pregnancy requiring delivery by emergency cesarean hysterectomy at 30 + 2 weeks of gestation.

Case Presentation: A 36-year-old woman, G3P2, with a DCDA twin pregnancy and known MAP presented to the labour ward at 30 + 2 weeks of gestation with evidence of pre-eclampsia and fulminating HELLP syndrome. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465756PMC

Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy.

Acta Med Okayama 2019 Apr;73(2):173-176

Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Read More

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http://dx.doi.org/10.18926/AMO/56653DOI Listing
April 2019
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Extracellular Vesicles in the Oviduct: Progress, Challenges and Implications for the Reproductive Success.

Bioengineering (Basel) 2019 Apr 12;6(2). Epub 2019 Apr 12.

Genetics and Functional Genomics Group, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.

The oviduct is the anatomical part of the female reproductive tract where the early reproductive events take place, from gamete transport, fertilization and early embryo development to the delivery of a competent embryo to the uterus, which can implant and develop to term. The success of all these events rely upon a two-way dialogue between the oviduct (lining epithelium and secretions) and the gametes/embryo(s). Recently, extracellular vesicles (EVs) have been identified as major components of oviductal secretions and pointed to as mediators of the gamete/embryo-maternal interactions. Read More

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http://dx.doi.org/10.3390/bioengineering6020032DOI Listing

Surface Body Temperature of Full-Term Healthy Newborns Immediately after Birth-Pilot Study.

Int J Environ Res Public Health 2019 Apr 12;16(8). Epub 2019 Apr 12.

Department of Functional Anatomy and Biometry, Faculty of Physical Education and Health Promotion, University of Szczecin, al. Piastów 40b/6, 71-065 Szczecin, Poland.

The aim of the study was to perform an evaluation of chosen body surface temperatures in neonates immediately after birth, and to seek a relationship between those temperatures and the factors related both to the mother and newborn. The study included 74 healthy newborns. Maternal age, body weight, body mass index before pregnancy and on delivery day, birth and pregnancy order, newborn sex, birth weight, body length, pregnancy week on delivery, as well as newborn gasometric test results were collected. Read More

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http://dx.doi.org/10.3390/ijerph16081312DOI Listing

Correlation between gross domestic product, utilization of in vitro fertilization and pregnancy success rate across the world.

J Med Econ 2019 Apr 23. Epub 2019 Apr 23.

c Department of Women and Children's Health , King's College London , UK.

IVF is now a wide spread procedure globally, and currently 65 countries report annually all or part of their IVF/ICSI cycles, from which the International Committee Monitoring progress in Assisted Reproduction Technology (ICMART) published its report. There is considerable variation in the utilisation (number of cycles per population) globally. The objectives of this study were to assess whether utilisation is related to national wealth, presented as gross domestic product (GDP) and whether the GDP has any effect on success in IVF treatment, mainly delivery and clinical pregnancy rates. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609484DOI Listing

Treatment guidelines for persistent cloaca, cloacal exstrophy, and Mayer-Rokitansky-Küster-Häuser syndrome for the appropriate transitional care of patients.

Surg Today 2019 Apr 22. Epub 2019 Apr 22.

Research Team for the Establishment of Treatment Guidelines for Persistent Cloaca, Cloacal Exstrophy and Mayer-Rokitansky-Küster-Häuser Syndrome for the Proper Transitional Care of the Patients, The Research Project for Rare and Intractable Diseases of the Ministry of Health, Labour and Welfare (MHLW), Tokyo, Japan.

We developed treatment guidelines (TGs) for appropriate transitional care of the genitourinary system in patients with persistent cloaca (PC), cloacal exstrophy (CE), or Mayer-Rokitansky-Küster-Häuser syndrome (MRKH). These TGs are in accordance with the Medical Information Network Distribution Service (Minds), published in 2014 in Japan. Clinical questions (CQs) concerning treatment outcomes of the genitourinary system, pregnancy and delivery, and quality of life in adulthood were prepared as six themes for PC and CE and five themes for MRKH. Read More

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http://dx.doi.org/10.1007/s00595-019-01810-zDOI Listing

The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage.

Adv Pharm Bull 2019 Feb 21;9(1):70-75. Epub 2019 Feb 21.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Although it has been frequently confirmed that HLA-G plays an important role in the reproduction and pregnancy, the pattern of HLA-G gene and its protein expression are rarely addressed in studies. Therefore we conducted this study in regard to evaluate the HLA-G gene and its protein expression in the women's placenta with recurrent miscarriage. Placental samples were obtained from the women who were admitted for delivery or abortion in Al Zahra and Taleghani hospitals, Tabriz, Iran. Read More

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http://dx.doi.org/10.15171/apb.2019.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468217PMC
February 2019

Spontaneous Orbital Hematoma in a 2-day Old Neonate: A Case Report.

Ethiop J Health Sci 2019 Mar;29(2):291-294

Jimma University, Department of Ophthalmology, Ethiopia.

Background: Intra-orbital hematoma is an eye disease that is usually attributed to trauma, neoplasm, acute sinusitis or vascular malformations. However, spontaneous hematoma is a rare condition and can be an early manifestation of hematological disorders.

Case Report: This is a case report on a 2-days old male neonate presented with proptosis of the right eye since the second day of birth. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460449PMC

Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications.

J Clin Med 2019 Apr 20;8(4). Epub 2019 Apr 20.

Institute for the Care of the Mother and Child, Third Faculty of Medicine, Charles University, 14700 Prague, Czech Republic.

The aim of the present study was to assess the long-term outcomes of women 3-to-11 years postpartum in relation to the previous occurrence of pregnancy-related complications such as gestational hypertension (GH), preeclampsia (PE) and fetal growth restriction (FGR). Body mass index (BMI), waist circumference values, the average values of systolic (SBP) and diastolic (DBP) blood pressures and heart rate, total serum cholesterol levels, serum HDL (high-density lipoprotein) cholesterol levels, serum LDL (low-density lipoprotein) cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum CRP (C-reactive protein) levels, plasma homocysteine levels, serum uric acid levels, individual and relative risks of having a heart attack or stroke over the next ten years were compared between groups (50 GH, 102 PE, 34 FGR and 90 normal pregnancies) and correlated with the severity of the disease with regard to clinical signs (25 PE without severe features, 77 PE with severe features), and delivery date (36 early PE, 66 late PE). The adjustment for potential covariates was made, where appropriate. Read More

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http://dx.doi.org/10.3390/jcm8040544DOI Listing

Outcome of pregnancies and deliveries before and after ischaemic stroke.

Eur Stroke J 2017 Dec 28;2(4):346-355. Epub 2017 Jul 28.

Clinical Neurosciences, Neurology, University of Helsinki, Finland.

Introduction: Limited data exist on the outcome of pregnancies and deliveries in women with ischaemic stroke. We investigated the incidence of pregnancy- and delivery-related complications in women with ischaemic stroke before and after pregnancy compared with stroke-free matched controls.

Patients And Methods: Of our 1008 consecutive patients aged 15-49 years with first-ever ischaemic stroke, 1994-2007, we included women with pregnancy data before or after stroke recorded in the Medical Birth Register (MBR) ( = 152), and for them searched stroke-free controls matched by age, parity, year of birth, residential area and multiplicity ( = 608). Read More

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http://dx.doi.org/10.1177/2396987317723795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453190PMC
December 2017

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Eur Stroke J 2017 Sep 21;2(3):250-256. Epub 2017 Apr 21.

Division of Epidemiology & Public Health, University of Nottingham, Nottingham, UK.

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women of childbearing age in Sweden.

Patients And Methods: All women aged 15-49 years with live births/stillbirths in 1992-2011 were identified from the Swedish Medical Birth Registry linked with the National Patient Registry. First stroke during the study period was identified. Read More

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http://dx.doi.org/10.1177/2396987317706600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454822PMC
September 2017

First trimester Doppler velocimetry of the uterine artery ipsilateral to the placenta improves ability to predict early-onset preeclampsia.

Medicine (Baltimore) 2019 Apr;98(16):e15193

Department of Statistics, University of Connecticut, Storrs, CT.

This study sought to investigate the effects of placental laterality on the measurements of uterine artery (UtA) Doppler velocimetry and their application in predicting early-onset preeclampsia (PE).We conducted a prospective cohort study on all women with singleton, uncomplicated pregnancies scheduled for first-trimester nuchal translucency at our institution. Pulsatility index (PI) for both UtAs was measured by Doppler velocimetry, and placental laterality was determined. Read More

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http://dx.doi.org/10.1097/MD.0000000000015193DOI Listing

Pregnancy Complications as a Window to Future Cardiovascular Disease.

Cardiol Rev 2019 Apr 12. Epub 2019 Apr 12.

Department of Obstetrics and Gynecology University of Michigan, Ann Arbor, Mi.

Pregnancy is a time of significant hemodynamic, metabolic, and hormonal stress that can unmask underlying subclinical cardiovascular abnormalities, and pregnancy-related complications may serve as early warning signs for future risk of cardiovascular disease. The increased recognition of these sex-specific risk factors could identify women who may benefit from more intensive risk factor modification to reduce morbidity and mortality later in life. In this review, we describe several pregnancy-related complications that have been associated with the risk of cardiovascular disease, including hypertensive disorders of pregnancy, gestational diabetes mellitus, preterm delivery, and pregnancy loss. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000253DOI Listing

Management of stroke and pregnancy.

Eur Stroke J 2018 Sep 12;3(3):227-236. Epub 2018 Apr 12.

Obstetrics, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Stroke continues to be one of the main causes of death in the developed countries and the incidence in pregnancy appears to be increasing. Pregnancy-related stroke has a relatively high mortality rate of 10% and so clinicians need to be mindful of appropriate investigations and referral of a pregnant woman with suspected stroke, so they can receive timely treatment. In this review we address the risk factors associated with stroke, diagnosis and appropriate management of the different stroke types. Read More

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http://dx.doi.org/10.1177/2396987318769547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453206PMC
September 2018

Amniotic Fluid Embolism in a Grown-Up Congenital Heart Disease Patient.

J Cardiovasc Echogr 2019 Jan-Mar;29(1):20-22

Department of Medicine and Surgery, Division of Cardiology, University of Salerno, Largo Città di Ippocrate, Salerno, Italy.

Amniotic fluid embolism (AFE) is a rare but potentially lethal obstetric condition affecting women during labor, delivery, or also in the immediate postpartum period, when amniotic fluid, fetal cells, hair, or other debris could enter the maternal circulation. We present the first case of AFE described in literature in a 33-year-old patient with a complex history of congenital heart disease, where the crucial points for successful course were the prompt recognition and treatment of the disease and the use, for the first time, as diagnostic tool for AFE, of right ventricular free-wall longitudinal speckle-tracking strain. Read More

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http://www.jcecho.org/text.asp?2019/29/1/20/254598
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http://dx.doi.org/10.4103/jcecho.jcecho_64_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450229PMC
April 2019
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Summary of the NACI Update on Immunization in Pregnancy with Tetanus Toxoid, Reduced Diphtheria Toxoid and Reduced Acellular Pertussis (Tdap) Vaccine.

Can Commun Dis Rep 2018 Mar 1;44(3-4):91-94. Epub 2018 Mar 1.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, OttawaON.

Background: In Canada, pertussis is an endemic and cyclical disease, with peaks occurring at two- to five-year intervals. Although pertussis incidence varies by age group, unvaccinated or undervaccinated infants are at greatest risk of infection and associated complications. Since the last National Advisory Committee on Immunization (NACI) recommendations published in 2014, new evidence on the safety and effectiveness of tetanus toxoid, reduced diphtheria toxoid and reduced acellular pertussis (Tdap) vaccine administration in pregnancy has become available. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449114PMC

Fetal movement frequency and the effect of associated perinatal factors: Multicenter study.

Women Birth 2019 Apr 28;32(2):127-130. Epub 2018 Jun 28.

Perinatal Center, Shiga University of Medical Science, Japan.

Background: Decreased fetal movements are associated with adverse perinatal outcomes, including stillbirth. Delayed maternal visits to a health care provider after perceiving decreased fetal movements are frequently observed in stillbirths. Informing pregnant women of the normal range of fetal movement frequency is essential in their earlier visits in order to prevent stillbirth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18715192183021
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http://dx.doi.org/10.1016/j.wombi.2018.06.010DOI Listing
April 2019
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Clinical and ultrasonographic parameters in assessment of labor induction success in nulliparous women.

J Matern Fetal Neonatal Med 2019 Apr 21:1-8. Epub 2019 Apr 21.

a Clinic of Obstetrics and Gynecology , Clinical Center of Serbia , Belgrade , Serbia.

Purpose: Evaluation of simplified Bishop score and ultrasound cervicometry in the assessment of labor induction success in nulliparous women.

Methods: Prospective cohort study included 146 nulliparous women with singleton pregnancy and indications for labor induction. Prior to labor induction, cervicometry and Bishop score were determined. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1594185DOI Listing
April 2019
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Fear of childbirth and associated factors among low-risk pregnant women.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

The aims of this study were to determine prevalence of childbirth fear among uncomplicated pregnant women in Siriraj Hospital and possible associated factors. A total of 305 uncomplicated, singleton pregnant women were enrolled during early third trimester. All participants were interviewed regarding baseline demographic, social, economic, family, and obstetric characteristics. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1584885DOI Listing
April 2019
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Fetal growth retardation and hemorheological predictors of oxygen delivery in hypertensive vs normotensive pregnant women.

Clin Hemorheol Microcirc 2019 Apr 16. Epub 2019 Apr 16.

U1046 INSERM, UMR 9214 CNRS « Physiopathologie & Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP », Unité d'Explorations Métaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France.

Physiological modifications of blood rheology during pregnancy and their alterations in pregnant hypertensive women have been extensively studied in the 1980's. Since vascular resistance is higher in hypertensive pregnant women whose newborns are small-for gestational-age (SGA), we investigated in a personal database if growth retardation of newborns is related to the oxygen delivery index (ratio hematocrit/blood viscosity) and to the difference between hematocrit (Hct) and the prediction of its optimal valued based on Quemada's equation. A sample of 38 hypertensive pregnant women (age 29 yr±1) was compared with 64 controls matched for age and gestational age, studied at 35±1 weeks gestation, extracted from a larger series of 162 pregnant women. Read More

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http://dx.doi.org/10.3233/CH-199002DOI Listing

Understanding Barriers to Uptake of 17 alpha-hydroxyprogesterone caproate (17-OHP) in Women with History of preterm Birth.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

e Denver Health and Hospital Authority , Women's Care Clinic , Denver , Colorado , USA.

Background: Premature birth is responsible for approximately 38% of infant deaths as well as a host of complications, including abnormal lung development, infection, and long-term disabilities. For women with a history of spontaneous preterm birth in a singleton pregnancy, use of 17 alpha-hydroxyprogesterone caproate (17-OHP) can reduce the risk of a recurrent preterm birth by up to 42%. However, less than half of eligible women currently receive 17-OHP. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610736DOI Listing

Oral misoprostol for induction of labour at term: A randomized controlled trial of hourly titrated and 2 hourly static oral misoprostol solution.

J Matern Fetal Neonatal Med 2019 Apr 21:1-211. Epub 2019 Apr 21.

c Department of Medical Social Services , Ekiti State University Teaching Hospital , Ado-Ekiti , Nigeria.

Background: Misoprostol has been shown to be effective in induction of labour (IOL) with different dosages and routes of administration.

Objectives: This study compared the efficacy and safety of hourly titrated and 2-hourly static low dose oral misoprostol for IOL in Ekiti State University Teaching Hospital, Ado-Ekiti.

Methods: One hundred fifty women with singleton pregnancy at term admitted for IOL were randomized into the two groups. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610378DOI Listing

Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
Publisher Site
http://dx.doi.org/10.5694/mja2.50125DOI Listing
April 2019
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