157,811 results match your criteria Pregnancy Delivery

Prenatal Antidepressant Use and the Implication of Hypertensive Disorders during Pregnancy.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, College of Pharmacy, Taipei Medical University. Electronic address:

Background: Evidence regarding prenatal antidepressant use and the development of hypertensive disorders during pregnancy is inconsistent. Previous studies have reported that antidepressant use during pregnancy increases the risk of gestational hypertension and preeclampsia, but the results of these studies are potentially confounded by important methodologic limitations. Furthermore, it remains unknown whether a higher cumulative dose of antidepressant increases the risk of hypertensive disorders of pregnancy. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Society for Maternal-Fetal Medicine (SMFM) Consult Series #56: Hepatitis C in Pregnancy: Updated Guidelines.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

In the United States, it is estimated that 1% to 4% of pregnant women are infected with hepatitis C virus, which carries approximately a 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. The purpose of this document is to discuss the current evidence, provide updated recommendations regarding screening, review treatment, and address management of hepatitis C virus during pregnancy. Read More

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Severe recalled labor pain and elective cesarean section in a subsequent delivery: a cohort study of Norwegian parous women.

Acta Obstet Gynecol Scand 2021 Jun 11. Epub 2021 Jun 11.

Institute and Policlinic of Occupational and Social Medicine, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.

Introduction: Some women keep on recalling intense labor pain experienced at childbirth to a degree that it may negatively affect their life during the postpartum period or lead them to request a cesarean section (CS) in the subsequent delivery. This longitudinal study aimed to assess the impact of severe recalled labor pain from the previous birth on the preference of and delivery by an elective CS in the subsequent delivery. Further, we investigated if co-occurring maternal demographic, somatic, and mental health factors related to the previous and subsequent delivery explain parts of a potential association. Read More

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Characterizing Hypertensive Disorders of Pregnancy Among Medicaid Recipients in a Nonexpansion State.

J Womens Health (Larchmt) 2021 Jun 10. Epub 2021 Jun 10.

Department of Health Care Organization and Policy, School of Public Health, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

The incidence of hypertensive disorders of pregnancy (HDP) are on the rise in the United States, especially in the South, which has a heavy chronic disease burden and large number of Medicaid nonexpansion states. Sizeable disparities in HDP outcomes exist by race/ethnicity, geography, and health insurance coverage. Our objective is to explore HDP in the Alabama Medicaid maternity population, and the association of maternal sociodemographic, clinical, and care utilization characteristics with HDP diagnosis. Read More

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The fetal outcomes after neoadjuvant platinum and paclitaxel chemotherapy during pregnancy: analysis of three cases and review of the literature.

Arch Gynecol Obstet 2021 Jun 11. Epub 2021 Jun 11.

Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 17 Qihelou St, Dongcheng District, Beijing, 100006, China.

Objective: Data on the outcomes of fetus who are exposed to neoadjuvant platinum and paclitaxel chemotherapy during pregnancy are lacking.

Methods: Relevant data were abstracted from patients in our institution, PubMed, Embase and Cochrane Library databases. The primary assessment was the frequency of fetal death and congenital abnormalities. Read More

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Acupoint injection combined with pelvic floor rehabilitation in the treatment of postpartum pelvic floor disorders: A protocol of randomized controlled trial.

Medicine (Baltimore) 2021 Jun;100(23):e25511

Chongqing Ninth People's Hospital.

Background: Female pelvic floor dysfunction is one of the common chronic diseases affecting women's physical and mental health. Pregnancy and delivery are one of the main causes. Pelvic floor rehabilitation is a common method for the treatment of postpartum pelvic floor dysfunction, but it has some defects. Read More

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Factors associated with longitudinal changes in B-vitamin and choline concentrations of human milk.

Am J Clin Nutr 2021 Jun 10. Epub 2021 Jun 10.

Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.

Background: Little is known regarding the associations between maternal factors and B-vitamin and choline concentrations in early milk and the trajectories of these vitamins during lactation.

Objectives: In this hypothesis-generating study, we modeled the association between maternal and offspring factors and longitudinal changes in milk B-vitamin and choline concentrations throughout lactation.

Methods: A hundred women were studied in a prospective birth cohort and milk samples from 52 women were collected at 2-8 d, 76 women at 28-50 d, and 42 women at 88-119 d postpartum. Read More

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Association of Gestational Diabetes Mellitus with Adverse Pregnancy Outcomes and Its Interaction with Maternal Age in Chinese Urban Women.

J Diabetes Res 2021 18;2021:5516937. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 10034, China.

Background: The prevalence of gestational diabetes mellitus (GDM) has been dramatically increasing worldwide. The aims of this study were to examine associations of GDM with pregnancy outcomes in Chinese urban women and to evaluate the interaction between GDM and other major risk factors for the risk of adverse pregnancy outcomes.

Methods: A retrospective analysis included 8844 women who delivered live singletons at ≥28 weeks of gestation between June 2012 and March 2013 among Chinese urban women. Read More

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Changes in trends and outcomes of eclampsia: a success story from Qatar.

Qatar Med J 2019 20;2019(1):10. Epub 2019 Sep 20.

Women's Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar.

Preeclampsia and eclampsia are two hypertensive disorders of pregnancy that significantly contribute to higher morbidity and mortality rates. Eclampsia is the occurrence of seizures in patients with preeclampsia without any previous history of seizure disorders. The incidence and prevalence of eclampsia varies, and there is scarce literature about the prevalence and trends of eclampsia in the Arabian Gulf countries. Read More

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September 2019

Understanding the Pathogenesis of Gestational Hypothyroidism.

Front Endocrinol (Lausanne) 2021 25;12:653407. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Pregnancy is a complex state with many endocrinological challenges to a woman's physiology. Gestational Hypothyroidism (GHT) is an emerging condition where insufficiency of the thyroid gland has developed during pregnancy in a previously euthyroid woman. It is different to overt hypothyroidism, where marked elevation of thyroid-stimulating hormone with corresponding reduction in free thyroxine levels, is well known to cause detrimental effects to both the mother and the baby. Read More

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Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery.

Environ Health 2021 Jun 10;20(1):68. Epub 2021 Jun 10.

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Durham, NC, 27709, USA.

Background: While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. Read More

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Pre-eclampsia: incidence, determinants, and pregnancy outcomes from maternity hospitals in Qatar: a population-based case-control study.

J Matern Fetal Neonatal Med 2021 Jun 10:1-9. Epub 2021 Jun 10.

Women's Wellness and Research Center, Doha, Qatar.

Background: We aimed to study the maternal characteristics and obstetric and neonatal outcomes in pregnant mothers with pre-eclampsia (PE) compared to normotensive.

Methods: This was a population-based retrospective data analysis. Data were obtained from the PEARL-Peristat Study perinatal registry (Perinatal Neonatal Outcomes Research Study in the Arabian Gulf) Qatar. Read More

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Relevance of maternal sodium level for preeclampsia-associated adverse pregnancy outcomes.

Pregnancy Hypertens 2021 May 29;25:110-115. Epub 2021 May 29.

Department of Obstetrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objective: To evaluate maternal sodium levels in women with preeclampsia (PE) or at high risk for preeclampsia and their relevance for severe PE-associated adverse pregnancy outcome and remaining pregnancy duration.

Study Design: In a retrospective cohort of 198 patients presenting with signs and symptoms of preeclampsia (PE), we investigated maternal sodium level and the sFlt-1/PlGF-ratio within 14 days prior to delivery.

Main Outcome Measures: In total, 88 patients (44. Read More

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Maternal and Fetal Vascular Lesions of Malperfusion in the Placentas Associated with Fetal and Neonatal Death: Results of a Prospective Observational Study.

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Columbia University, New York NY USA.

Background: Fetal death, one of the major adverse pregnancy outcomes, is especially common in low and middle-income countries. Placental lesions may play an important role in the etiology of fetal and possibly neonatal death. Prior research relating placental lesions to fetal death causation was often hindered by the lack of agreement on a placental classification scheme. Read More

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Maternal and fetal outcomes associated with infective endocarditis in pregnancy.

Clin Infect Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.

Introduction: Infective endocarditis (IE) is a rare but serious infection complicating pregnancy. Little is known about IE management and outcomes in this population.

Methods: The National Readmissions Database was used to obtain data between October 2015 and October 2018. Read More

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Prevention of Mother-to-Child HIV Transmission in Nigeria: Six Years Experience from a Tertiary Institution.

Curr HIV Res 2021 Jun 7. Epub 2021 Jun 7.

Africa Center of Excellence for Population Health and Policy (ACEPHAP), Bayero University, Kano, Nigeria.

Background: In line with global standards and progress made in Prevention of Mother-to-Child Transmission (PMTCT), an assessment of the outcome of Early Infant Diagnosis in northern Nigeria is necessary to evaluate progress towards a zero Human immunodeficiency Virus (HIV) infection rate among children.

Objectives: This study assessed the infection rate and risk factors for mother-to-child HIV transmission among HIV-exposed children in Kano, northwest Nigeria.

Method: Using a retrospective cohort design, pregnant HIV-positive women and their exposed infants were recruited over a period of six years (2010 to 2016). Read More

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Can we improve our ability to interpret category II fetal heart rate tracings using additional clinical parameters?

J Perinat Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Objectives: This study examined predictive factors, in addition to Category II Fetal Herat Rate (FHR) monitoring that might imply fetal acidosis and risk of asphyxia.

Methods: This retrospective cohort study compared three groups of patients with Category II FHR monitoring indicating need for imminent delivery. Groups were divided based on fetal cord blood pH: pH≤7. Read More

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Clinical utility of 1-month postpartum random plasma glucose and HbA1c combined with pre-pregnancy body mass index for detecting postpartum glucose intolerance in Japanese women with gestational diabetes.

J Diabetes Investig 2021 Jun 10. Epub 2021 Jun 10.

Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

During the coronavirus disease 2019 pandemic, the Japanese Society of Diabetes and Pregnancy (JSDP) proposed the use of random plasma glucose and HbA1c measured 1 month after delivery combined with pre-pregnancy body mass index to detect postpartum glucose intolerance instead of performing oral glucose tolerance test (OGTT) in women with gestational diabetes. We retrospectively evaluated the clinical utility of this strategy to detect postpartum glucose intolerance evaluated by OGTT after delivery. Two hundred and seventy-five Japanese women with gestational diabetes were included in the present study. Read More

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The difficulty to diagnose cervical cancer developing in the perinatal period with the first-trimester cytology: A retrospective study.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Hokkaido University Hospital, Sapporo, Japan.

Aim: Cytological cervical cancer screening for pregnant women is routinely performed and still plays an essential role in Japan because of the considerably low rate of human pappillomavirus (HPV) vaccination. Though almost all pregnant women undergo cytological screening at their first trimester, we experienced invasive cervical cancers (ICC) diagnosed during pregnancy or postpartum period. We investigated the characteristics of perinatally diagnosed ICCs to clarify the difficulty in diagnosis during the pregnancy. Read More

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Pregnancy-induced effects on memory B-cell development in multiple sclerosis.

Sci Rep 2021 Jun 9;11(1):12126. Epub 2021 Jun 9.

Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.

In MS, pathogenic memory B cells infiltrate the brain and develop into antibody-secreting cells. Chemokine receptors not only define their brain-infiltrating capacity, but also assist in their maturation in germinal centers. How this corresponds to pregnancy, as a naturally occurring modifier of MS, is underexplored. Read More

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Predictors of later insulin therapy for gestational diabetes diagnosed in early pregnancy.

Endocr J 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Interventions for gestational diabetes mellitus (GDM), diagnosed in early pregnancy, have been a topic of controversy. This study aimed to elucidate factors that predict patients with GDM diagnosed before 24 gestational weeks (early GDM: E-GDM) who require insulin therapy later during pregnancy. Furthermore, we identified patients whose impaired glucose tolerance should be strictly controlled from early gestation onward. Read More

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Knowledge on intrapartum care practices among skilled birth attendants in Cambodia-a cross-sectional study.

Reprod Health 2021 Jun 9;18(1):115. Epub 2021 Jun 9.

Project for Improving Continuum of Care with focus on Intrapartum and Neonatal Care in Cambodia, Japan International Cooperation Agency, Building 61-64, Preah Norodom Blvd, Phnom Penh, Cambodia.

Background: Delivery is a critical moment for pregnant women and babies, and careful monitoring is essential throughout the delivery process. The partograph is a useful tool for monitoring and assessing labour progress as well as maternal and foetal conditions; however, it is often used inaccurately or inappropriately. A gap between practices and evidence-based guidelines has been reported in Cambodia, perhaps due to a lack of evidence-based knowledge in maternity care. Read More

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A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border.

BMC Med 2021 Jun 10;19(1):132. Epub 2021 Jun 10.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

Background: Artemisinin and artemisinin-based combination therapy (ACT) partner drug resistance in Plasmodium falciparum have spread across the Greater Mekong Subregion compromising antimalarial treatment. The current 3-day artemether-lumefantrine regimen has been associated with high treatment failure rates in pregnant women. Although ACTs are recommended for treating Plasmodium vivax malaria, no clinical trials in pregnancy have been reported. Read More

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Pregnancy-related acute kidney injury at high altitude: a retrospective observational study in a single center.

BMC Nephrol 2021 Jun 9;22(1):215. Epub 2021 Jun 9.

Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Pregnancy-related acute kidney injury (Pr-AKI) is associated with maternal and fetal morbidity and mortality. There are few studies focusing on Pr-AKI at high altitude in the literature.

Objectives: to investigate the incidence, etiology, clinical features and maternal-fetal outcomes of Pr-AKI in women living at high altitude. Read More

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Peripartum anesthetic management of women with SARS-CoV-2 infection in eight medical centers across three European countries: prospective cohort observation study.

J Matern Fetal Neonatal Med 2021 Jun 9:1-8. Epub 2021 Jun 9.

Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Objective: Several reports of obstetric anesthesia management have been published since the onset of the COVID-19 pandemic. We aimed to collect high-quality broad and detailed data from different university medical centers in several European Society of Anesthesiologist countries.

Methods: This prospective observational survey was performed in eight medical centers in Spain, Israel and Portugal from 1 April to 31 July 2020. Read More

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Pregnancy-related comorbidities and labor induction - the effectiveness and safety of dinoprostone compared to misoprostol.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Cracow, Poland.

Objectives: The aim of the study was to evaluate whether the presence of the disease in pregnancy influences the effectiveness and safety of delivery preinduction with prostaglandins: misoprostol vaginal insert and dinoprostone vaginal gel.

Material And Methods: This is aretrospective cohort study conducted of 560 pregnant women. The concomitant diseases mainly recorded were diabetes mellitus, hypertensive diseases, intrahepatic cholestasis of pregnancy, asthma, thrombocytopenia, and hypothyroidism. Read More

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The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Bursa Yüksek İhtisas Training and Research Hospital Department of Gynecology and Obstetrics, Bursa, Turkey.

Objectives: We aimed to compare perinatal outcomes of oligohydramnios or fetal growth restriction with normal amniotic fluid index and fetal growth in preeclampsia and to compare the outcomes of only oligohydramnios, only fetal growth restriction and oligohydramnios with fetal growth restriction preeclamptic groups.

Material And Methods: A total of 743 preeclamptic patients were evaluated between June 2016 and 2020. Patients were divided into two groups: preeclampsia with oligohydramnios or fetal growth restriction (n = 237) and preeclampsia with normal amniotic fluid index and fetal growth (n = 506). Read More

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Perinatal and neonatal outcome in patients with preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

International Centre for Cancer Vaccine Science Cancer Immunology Group, University of Gdansk, Poland.

Objectives: Preeclampsia (PE) affects 2-5% of pregnant women. Hypertensive disorders of pregnancy are associated with adverse maternal and perinatal outcomes.

Material And Methods: This study included 88 women showing gestational hypertension (GH) or PE symptoms, and their newborns. Read More

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