5,392 results match your criteria Pregnancy Asthma


Prenatal Negative Life Events and Childhood Allergies: The Japan Environment and Children's Study (JECS).

Int Arch Allergy Immunol 2022 May 19:1-9. Epub 2022 May 19.

Department of Health Sciences, School of Medicine, University of Yamanashi, Yamanashi, Japan.

Background: It is inconclusive whether prenatal negative life events are a risk for the development of allergic diseases in children or whether social capital modifies the association. The objective of this study was to examine whether women's experiences of such events during pregnancy were associated with the development of allergic diseases in their offspring at 3 years old and whether social capital moderated this association.

Methods: We used data from 81,337 mother-child pairs who participated in the Japan Environment and Children's Study. Read More

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Long term impact of prophylactic antibiotic use before incision versus after cord clamping on children born by caesarean section: longitudinal study of UK electronic health records.

BMJ 2022 May 17;377:e069704. Epub 2022 May 17.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Objective: To investigate the impact on child health up to age 5 years of a policy to use antibiotic prophylaxis for caesarean section before incision compared with after cord clamping.

Design: Observational controlled interrupted time series study.

Setting: UK primary and secondary care. Read More

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Developmental Effects of Electronic Cigarette Use.

Compr Physiol 2022 Mar 29;12(2):3337-3346. Epub 2022 Mar 29.

Division of Pediatric Pulmonology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Electronic cigarettes have gained widespread acceptance among adolescents and young adults. As a result of this popularity, there are concerns regarding the potential harm of primary, secondhand and thirdhand electronic cigarette exposures on fetal and postnatal development. In vitro studies have shown that constituents in electronic cigarette liquids, including nicotine, flavorings, and carrier agents can alter cellular processes and growth. Read More

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Atopic heredity modifies the association between maternal vitamin D status in pregnancy and the risk of atopic disease in childhood: an observational study.

Nutr J 2022 May 17;21(1):32. Epub 2022 May 17.

Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The relationship between maternal vitamin D status in pregnancy and the development of atopic diseases in the offspring has been frequently studied, but with contradictory results. Previous studies have found an inverse relation between maternal vitamin D in pregnancy and the risk of atopic diseases in the child. In contrast, others have found a higher maternal 25OHD to be related to a higher risk of atopic diseases. Read More

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Obesity and Maternal-Placental-Fetal Immunology and Health.

Front Pediatr 2022 28;10:859885. Epub 2022 Apr 28.

New York State Department of Health, Wadsworth Center, Albany, NY, United States.

Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports. It is known that obesity is associated with oxidative stress and inflammation, including disruptions in cellular function and cytokine levels. In pregnant women who are obese, associated placental dysfunction can lead to small for gestational age (SGA) infants. Read More

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The Role of Breastfeeding on Respiratory Outcomes Later in Childhood.

Front Pediatr 2022 28;10:829414. Epub 2022 Apr 28.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Background: Breastfeeding is associated with a lower risk of wheezing in early childhood, but its effect later in childhood remains unclear. We investigated the association of breastfeeding and respiratory outcomes in children aged 11 years.

Materials And Methods: We performed an observational longitudinal study including 110 prepubertal children. Read More

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IL-33-ILC2 axis in the female reproductive tract.

Trends Mol Med 2022 May 12. Epub 2022 May 12.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada. Electronic address:

IL-33 is a member of the IL-1 family and was first identified as an alarmin that acts at mucosal barrier sites. However, IL-33 is now understood to be a pleiotropic cytokine that acts on a variety of immune and non-immune cell types to promote type 2 T helper cell (T2) inflammation as well as to regulate and suppress homeostatic processes. Of particular interest are group 2 innate lymphoid cells (ILC2s) which are activated by IL-33 and promote many IL-33-specific effects. Read More

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Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children.

Nutrients 2022 May 1;14(9). Epub 2022 May 1.

Andrology Section, Endocrinology, Metabolism and Nuclear Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires PC C1199ABB, Argentina.

A worldwide high prevalence of vitamin D (VD) deficiency has become of growing concern because of potential adverse effects on human health, including pregnant women and their offsprings. Beyond its classical function as a regulator of calcium and phosphate metabolism, together with its fundamental role in bone health in every stage of life, its deficiency has been associated to multiple adverse health effects. The classic effects of VD deficiency in pregnancy and neonates have been late hypocalcemia and nutritional rickets. Read More

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Do Probiotics in Pregnancy Reduce Allergies and Asthma in Infancy and Childhood? A Systematic Review.

Nutrients 2022 Apr 28;14(9). Epub 2022 Apr 28.

School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.

The maternal immune system is very important in the development of the foetal immune system. Probiotics have been shown to help regulate immune responses. Therefore, it is possible that the administration of probiotics to pregnant women could influence the development of the foetal immune system, reducing the likelihood of infants and children developing an allergic condition. Read More

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Maternal obesity, gestational weight gain and offspring asthma and atopy.

Ann Allergy Asthma Immunol 2022 May 9. Epub 2022 May 9.

Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. Electronic address:

Background: Maternal obesity may affect offspring asthma and atopic disease risk by altering fetal immune system development. However, few studies examine gestational weight gain (GWG).

Objective: Examine relationships between maternal body mass index (BMI), GWG, and persistent wheeze, eczema, allergy, and asthma risk in offspring through middle childhood. Read More

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The association between duration of breastfeeding and childhood asthma outcomes.

Ann Allergy Asthma Immunol 2022 May 9. Epub 2022 May 9.

Division of General Pediatrics, Department of Pediatrics, The Icahn School of Medicine at Mount Sinai. Electronic address:

Background: Postnatal exposures, including breastfeeding, may influence asthma development.

Objective: To investigate the association between breastfeeding duration and child asthma.

Methods: We studied 2,021 mother-child dyads in the ECHO PATHWAYS consortium of prospective pregnancy cohorts (GAPPS, CANDLE, TIDES). Read More

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Effect of maternal ozone exposure before and during pregnancy on wheezing risk in offspring: A birth cohort study in Guangzhou, China.

Environ Res 2022 May 10;212(Pt C):113426. Epub 2022 May 10.

Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, 510080, China; Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou 510632, China. Electronic address:

Ozone (O) exposure may lead to the development and exacerbation of asthma or wheezing in postnatal children; however, it has rarely been studied before and during pregnancy. Wheezing is one of the most common symptoms when diagnosing of asthma; thus, we investigated the associations of O exposure before and during pregnancy with wheezing in preschool children and the potential susceptible exposure windows from a heavily polluted city in China. This population-based birth cohort study, which included 3725 mother-child pairs from Guangzhou, began in 2016, and the follow-up period ended on July 31, 2020. Read More

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The safety of pranlukast and montelukast during the first trimester of pregnancy: a prospective, two-centered cohort study in Japan.

Congenit Anom (Kyoto) 2022 May 10. Epub 2022 May 10.

Department of Pharmacy, Yamagata University Hospital, Yamagata, Japan.

For leukotriene receptor antagonists (LTRAs), especially pranlukast, safety data during pregnancy is limited. Therefore, we conducted a prospective, two-centered cohort study using data from teratogen information services in Japan to clarify the effects of LTRA exposure during pregnancy on maternal and fetal outcomes. Pregnant women who being counseled on drug use during pregnancy at two facilities were enrolled. Read More

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Asthma susceptibility in prenatal nicotine-exposed mice attributed to β-catenin increase during CD4 T cell development.

Ecotoxicol Environ Saf 2022 Jun 6;238:113572. Epub 2022 May 6.

Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China. Electronic address:

Cigarette smoke is a common global environmental pollutant. Asthma, the most frequent allergic airway disease, is related to maternal exposure to cigarette smoke. Our previous studies demonstrated that prenatal exposure to nicotine (PNE), the major active product of smoking, impairs fetal thymopoiesis and CD4 T cell development after birth. Read More

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The impact of COVID-19 on smoking cessation in pregnancy.

J Perinat Med 2022 May 10. Epub 2022 May 10.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Objectives: A greater proportion of non-pregnant smokers attempted to stop smoking during compared to before the COVID-19 pandemic. The objective of this study was to determine if a greater proportion of pregnant women also attempted to stop smoking during the pandemic rather than before.

Methods: The use of antenatal smoking cessation services and nicotine replacement therapies (NRT) in pregnant women was audited before (2019-2020) and during the COVID pandemic (2020-2021). Read More

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Updated guidelines (2021) for management and follow-up of asthmatic patients of the French Society of Pneumology (SPLF) and the French Society of Pediatric Pneumology and Allergology (SP2A). Short version.

Respir Med Res 2022 May 5;81:100898. Epub 2022 May 5.

Pneumology department, Guadeloupe University Hospital, Pointe-à-Pitre, French West Indies; Respiratory Tract Pole, Toulouse University Hospital, Toulouse, France.

The therapeutic management strategy is based on the regular evaluation of the control of asthmatic disease, with an effective minimum dose research and the assessment of environmental factors, not to mention the important place of therapeutic education. These professional recommendations relate to the management and follow-up of adult and adolescent asthma patients aged 12 and over. The recommendations answer the following questions: 1. Read More

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Patterns of contraceptive use among young Australian women with chronic disease: findings from a prospective cohort study.

Reprod Health 2022 May 7;19(1):111. Epub 2022 May 7.

Centre for Women's Health Research, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia.

Background: Given chronic disease is increasing among young women and unintended pregnancies among these women are associated with poor maternal and fetal outcomes, these women would benefit from effective preconception care. However, there is a lack of understanding of how these women use or don't use contraception to inform such interventions. This study examined patterns of contraceptive use among an Australian cohort of young women and investigated the influence of chronic disease on contraceptive use over time. Read More

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Allergic rhinitis is associated with thromboembolic disease in pregnancy.

Sci Rep 2022 May 4;12(1):7236. Epub 2022 May 4.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Finding the risk factors for thromboembolic (TE) disease and preventing its development in pregnant women is important. Allergic rhinitis (AR) is a common chronic disease. We aim to find if AR is a risk factor. Read More

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Dietary exposures and allergy prevention in high-risk infants.

Allergy Asthma Clin Immunol 2022 Apr 30;18(1):36. Epub 2022 Apr 30.

Department of Pediatrics, Section of Allergy and Clinical Immunology, University of Manitoba, FE125-685 William Avenue, Winnipeg, MB, R2A 5L9, Canada.

Infants at high risk for developing a food allergy have either an atopic condition (such as eczema) themselves or an immediate family member with such a condition. Breastfeeding should be promoted and supported regardless of issues pertaining to food allergy prevention, but for infants whose mothers cannot or choose not to breastfeed, using a specific formula (i.e. Read More

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Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort.

Front Nutr 2022 12;9:869357. Epub 2022 Apr 12.

Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.

Background: Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available.

Objective: We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring.

Methods: Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Read More

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Predictors and biomarkers of food allergy and sensitization in early childhood.

Ann Allergy Asthma Immunol 2022 Apr 28. Epub 2022 Apr 28.

Division of Allergy and Immunology, Center for Food Allergy, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Golisano Children's Hospital, Rochester, NY; Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address:

Objective: To review existing literature on the early risk factors for and biomarkers of food allergy (FA) and food sensitization (FS) and highlight opportunities for future research that will further understanding of FA pathogenesis in infancy and toddlerhood.

Data Sources: PubMed search of English-language articles related to food allergy and atopic disease STUDY SELECTIONS: Human studies with outcomes related to FA, FS, and other atopic disease in childhood were selected and reviewed. Studies published after 2015 were prioritized. Read More

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Exposure to Allergen-Specific Immunotherapy in Pregnancy and Risk of Congenital Malformations and Other Adverse Pregnancy Outcomes.

J Allergy Clin Immunol Pract 2022 Apr 16. Epub 2022 Apr 16.

Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.

Background: Owing to insufficient data, current guidelines recommend against initiating allergen-specific immunotherapy (AIT) during pregnancy but suggest that well-tolerated ongoing immunotherapy may be continued.

Objective: To evaluate the safety of AIT in pregnancy, especially the risk for congenital malformations.

Methods: This nationwide Swedish cohort study identified pregnancies exposed to AIT, both subcutaneous and sublingual, through the Swedish Medical Birth register and the Prescribed Drug Register between 2005 and 2014. Read More

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Ondansetron use in nausea and vomiting during pregnancy: A descriptive analysis of prescription patterns and patient characteristics in UK general practice.

Br J Clin Pharmacol 2022 Apr 28. Epub 2022 Apr 28.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Aims: The objective of this study was to describe ondansetron drug utilization patterns during pregnancy to treat nausea and vomiting in pregnancy (NVP). Moreover, we aimed to describe the maternal factors associated with NVP and antiemetic use.

Methods: The data consist of pregnancies with a live birth(s) within an IMRD-UK registered GP practice. Read More

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Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma.

Authors:
Bronwyn K Brew

Aust N Z J Obstet Gynaecol 2022 04;62(2):E3-E4

National Perinatal Epidemiology and Statistics Unit, Centre for Big Data Research in Health and School of Women & Children's Health, UNSW, Sydney, New South Wales, Australia.

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Determinants of hyperemesis gravidarum among pregnant women attending health care service in public hospitals of Southern Ethiopia.

PLoS One 2022 26;17(4):e0266054. Epub 2022 Apr 26.

School of Nursing, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Hyperemesis gravidarum is severe nausea and excessive vomiting, starting between 4 and 6 gestational weeks, peak at between 8 and 12 weeks and usually improve and subside by 20 weeks of pregnancy. Identifying the determinants of hyperemesis gravidarum has a particular importance for early detection and intervention to reduce the health, psychosocial and economic impact. In Ethiopia there is low information on determinants of hyperemesis gravidarum. Read More

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