45,816 results match your criteria Preeclampsia


LncRNA SNHG16 regulates trophoblast functions by the miR-218-5p/LASP1 axis.

J Mol Histol 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huaiyin District, Huaian , 223300, Jiangsu, China.

Altered placental development and function lead to placental diseases such as preeclampsia (PE) which is mainly characterized by insufficient trophoblast invasion and abnormally invasive placenta disorders. Long noncoding RNAs (lncRNAs) are widely reported to function as crucial players in the pathogenesis of PE. The present investigation clarified the role of lncRNA small nucleolar RNA host gene 16 (SNHG16) in PE. Read More

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Long intergenic noncoding RNA 00473 promoting migration and invasion of trophoblastic cell line HTR-8/SVneo via regulating miR-424-5p-mediated wnt3a/β-catenin signaling pathway.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics, Ningbo First Hospital, Ningbo, China.

Background: Preeclampsia (PE) is a serious obstetric complication. Recent studies point out that the functions of long intergenic noncoding RNA 00473 (linc00473), miR-424-5p, and Wnt/β-catenin signaling pathway were involved in the invasion and migration of extravillous trophoblast. Here, we investigated the role and mechanism of linc00473 in HTR-8/SVneo trophoblastic cell line and its role in PE. Read More

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The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome.

Expert Rev Proteomics 2021 Jun 9. Epub 2021 Jun 9.

Neonatal Intensive Care Unit, Department of Surgical Sciences, AOU and University of Cagliari. SS 554 km 4,500, 09042 Monserrato. Italy.

Introduction: Pre-pregnancy overweight and obesity, depending on maternal nutrition and metabolic state, can influence fetal, neonatal and long-term offspring health, regarding cardio-metabolic, respiratory, immunological and cognitive outcomes. Thus, maternal weight can act, through mechanisms that are not full understood, on the physiology and metabolism of some fetal organs and tissues, to adapt themselves to the intrauterine environment and nutritional reserves. These effects could occur by modulating gene expression, neonatal microbiome, and through breastfeeding. Read More

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Effect of IL-15-Mediating IFN-γ on HTR-8/SVneo Cells and a Preeclampsia Mouse Model Induced by Lipopolysaccharides.

Authors:
Xiao-Lu Wang

Gynecol Obstet Invest 2021 Jun 9:1-10. Epub 2021 Jun 9.

Department of Obstetrics, Yantai Yantaishan Hospital, Yantai, China.

Objective: Determine the effect of interleukin (IL)-15 on HTR-8/SVneo cells and a preeclampsia (PE) mouse model induced by LPS.

Methods: Transwell and Annexin-V-FITC/PI assays were performed in HTR-8/SVneo cells transfected with IL-15 activation plasmid/siRNA prior to LPS treatment. Additionally, pregnant mice were injected with LPS and IL-15 siRNA followed by measurement of systolic blood pressure (SBP), urine protein, and serum NO. Read More

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The Association between Maternal Placental Growth Factor and Placental Maternal Vascular Malperfusion Lesions.

J Gynecol Obstet Hum Reprod 2021 Jun 6:102179. Epub 2021 Jun 6.

Reproduction, Mother and Child Health Unit, CHU de Québec-Université Laval Research Center, Université Laval, Quebec City, Canada; Department of Obstetrics and Gynecology, Faculty of Medicine, CHU de Québec-Université Laval, Quebec City, Canada. Electronic address:

Introduction: Placental Growth Factor (PlGF) is used for the prediction of preeclampsia (PE), a syndrome associated with maternal vascular malperfusion (MVM). Our goal is to determine the correlation between PlGF and MVM.

Material And Methods: We performed a secondary analysis of the PEARL study that included nulliparous women with PE (cases), and low-risk nulliparous women recruited in early pregnancy (controls). Read More

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Role of platelet indices in prediction of preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

HSU Bursa Yüksek İhtisas Training and Research Hospital, Bursa Yüksek İhtisas Eğitim ve araştırma Hastanesi Mimar sina mah emniyet cad yıldırım, Bursa, Turkey.

Objectives: To compare platelet indices in preeclamptic and normotensive pregnants and to investigate the clinical use of these parameters in preeclampsia prediction.

Material And Methods: This retrospective case- control study included 257 preeclampsia patients and 264 healthy pregnant women as the control group. The groups were compared in terms of platelet count (PC), mean platelet volume (MPV), platelet distribution range (PDW), plateletcrit (Pct), Pct / MPV ratio and PC / MPV ratio. Read More

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Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics, Maternal and child health hospital of Hunan Province Changsha, Hunan, China.

Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia. Read More

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The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Bursa Yüksek İhtisas Training and Research Hospital Department of Gynecology and Obstetrics, Bursa, Turkey.

Objectives: We aimed to compare perinatal outcomes of oligohydramnios or fetal growth restriction with normal amniotic fluid index and fetal growth in preeclampsia and to compare the outcomes of only oligohydramnios, only fetal growth restriction and oligohydramnios with fetal growth restriction preeclamptic groups.

Material And Methods: A total of 743 preeclamptic patients were evaluated between June 2016 and 2020. Patients were divided into two groups: preeclampsia with oligohydramnios or fetal growth restriction (n = 237) and preeclampsia with normal amniotic fluid index and fetal growth (n = 506). Read More

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Perinatal and neonatal outcome in patients with preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

International Centre for Cancer Vaccine Science Cancer Immunology Group, University of Gdansk, Poland.

Objectives: Preeclampsia (PE) affects 2-5% of pregnant women. Hypertensive disorders of pregnancy are associated with adverse maternal and perinatal outcomes.

Material And Methods: This study included 88 women showing gestational hypertension (GH) or PE symptoms, and their newborns. Read More

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Serum S100B Protein Concentrations in SGA/FGR newborns.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neonatology, Children Clinical Hospital, Medical University of Warsaw, Poland.

Objectives: Fetal growth restriction is associated with chronic fetal hypoxia, poor perinatal outcome and increased perinatal mortality. There are no reliable methods to detect cell damage in the central nervous system (CNS) in these patients. The findings of increased an acidic calcium-binding protein (S100B) concentration in biological fluids of infants after brain injury have supported the use of S100B as a biochemical marker of CNS damage. Read More

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Predictive value of maternal serum podocalyxin in the diagnosis of preeclampsia: a prospective case-control study.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Biochemistry, Doctor Lufti Kirdar Kartal Training and Research Hospital, Istanbul, Turkey.

Objective: s: There is a need for markers to facilitate the diagnosis of preeclampsia, one of the most chief causes of maternal and infant mortality. Preeclampsia causes damage to the glomeruli and vascular endothelium in pregnant women. Podocalyxin is a sialoglycoprotein found in both glomeruli and vascular endothelium. Read More

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Immunological Comparison of Pregnant Dahl Salt-Sensitive and Sprague Dawley Rats Commonly Used to Model Characteristics of Preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmacology and Toxicology, grid.410721.1University of Mississippi Medical Center, Jackson, MS, United States.

The pregnant Dahl salt-sensitive (S) rat is an established pre-clinical model of superimposed spontaneous preeclampsia characterized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying immune system dysfunction present in preeclamptic pregnancies in humans, we hypothesized that the pregnant Dahl S rat would also have an altered immune status. Immune system activation was assessed during late pregnancy in the Dahl S model and compared to healthy pregnant Sprague Dawley (SD) rats subjected to either a sham procedure or a procedure to reduce uterine perfusion pressure (RUPP). Read More

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Adverse Neonatal Outcome are More Common among Babies Born by Cesarean Section than Naturally Born Babies at Public Hospitals in Eastern Ethiopia: A Comparative Prospective Follow-Up Study at Eastern Ethiopia.

Glob Pediatr Health 2021 25;8:2333794X211018350. Epub 2021 May 25.

Haramaya University, Harar, Ethiopia.

The adverse neonatal outcome is defined as the presence of birth asphyxia, respiratory distress, birth trauma, hypothermia, meconium aspiration syndrome, neonatal intensive care admission, and neonatal death. It is a major concern in developing countries, including Ethiopia. This study tried to identify predictors of adverse neonatal outcomes at selected public hospitals in Eastern Ethiopia. Read More

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Pulmonary arterial hypertension in pregnancy-a systematic review of outcomes in the modern era.

Pulm Circ 2021 Apr-Jun;11(2):20458940211013671. Epub 2021 May 14.

Division of Cardiology, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade. We searched for articles describing outcomes in pregnancy cohorts published between 2008 and 2018. Read More

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Diagnostic value of doppler ultrasound indices of maternal renal interlobar vasculature in the prediction of preeclampsia.

J Med Life 2021 Mar-Apr;14(2):277-283

Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

We aimed to determine the diagnostic accuracy of maternal renal vasculature Doppler ultrasound indices in the prediction of preeclampsia. A total of 40 pregnant women with a gestational age of more than 20 weeks were included and followed. The pregnant women underwent a Doppler ultrasound examination to measure the resistance index (RI) of the interlobar arteries of right and left kidneys and the renal interlobar vein impedance index (RIVI). Read More

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Prevalence-pattern and risk factors of Cesarean section in a multiethnic cohort.

Pak J Med Sci 2021 May-Jun;37(3):711-715

Sajid Malik, Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Objective: This study was aimed to elucidate the prevalence-pattern and determinant of cesarean section (CS) in a multiethnic cohort from Pakistan.

Methods: Through a cross-sectional study design, women delivering at a tertiary care center were recruited during 2013-2017. Data on socio-demographic variables, obstetric complications and birth outcome were obtained. Read More

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A retrospective cohort study of race/ethnicity, pre-pregnancy weight, and pregnancy complications.

J Matern Fetal Neonatal Med 2021 Jun 8:1-8. Epub 2021 Jun 8.

Department of Health Services, School of Public Health, University of Washington, Seattle, WA, USA.

Objective: To examine the relationship between race/ethnicity, pre-pregnancy overweight/obesity status, and pregnancy complications.

Methods: We conducted a retrospective cohort study among mothers with singleton live births using data from hospitals contributing to the Obstetrical Care Outcomes Assessment Program database ( = 72,697). Race was categorized as Non-Hispanic (NH) White, NH African-American, Hispanic, NH Asian, NH American Indian/Alaskan Native, and NH Native-Hawaiian/Other Pacific Islander. Read More

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Prenatal endothelin or thromboxane receptor antagonism surpasses sympathoinhibition in improving cardiorenal malfunctions in preeclamptic rats.

Toxicol Appl Pharmacol 2021 Jun 6;426:115615. Epub 2021 Jun 6.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt; Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait. Electronic address:

Current therapies for preeclampsia (PE) and its complications are limited and defective. Considering the importance of endothelin (ET) and thromboxane A2 (TXA2) signaling in PE pathophysiology, we tested the hypothesis that prenatal blockade of endothelin ETA or thromboxane TXA2 receptors favorably reprograms preeclamptic cardiovascular and renal insults. PE was induced by daily oral administration of L-NAME (50 mg/kg) to pregnant rats for 7 consecutive days starting from gestational day 14. Read More

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Assembly of Cytoplasmic Stress Granules in Placentas in Women with Preeclampsia.

Reprod Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, Qingdao Women and Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 266034, Shandong Province, China.

Inflammation is a well-recognized factor associated with preeclampsia (PE). Stress granules (SGs) have been shown to play an important role in regulating inflammation and immune responses. However, whether SGs are involved in the pathogenesis of PE has not been studied. Read More

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Racial Disparities in Cardiovascular Complications With Pregnancy-Induced Hypertension in the United States.

Hypertension 2021 Jun 8:HYPERTENSIONAHA12117104. Epub 2021 Jun 8.

From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (A.S.M., A.G.H., E.D.M.).

Women with pregnancy-induced hypertension, defined as gestational hypertension and preeclampsia/eclampsia, are at increased risk of long-term cardiovascular disease, but less is known about the spectrum of acute cardiovascular outcomes, especially across racial/ethnic groups. We evaluated the risk of cardiovascular events at delivery associated with gestational hypertension and preeclampsia/eclampsia, compared with no pregnancy-induced hypertension, overall and by race/ethnicity. We used the 2016 to 2018 National Inpatient Sample data. Read More

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Comprehensive transcriptome mining identified the gene expression signature and differentially regulated pathways of the late-onset preeclampsia.

Pregnancy Hypertens 2021 May 28;25:91-102. Epub 2021 May 28.

Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Preeclampsia (PE) is categorized as a pregnancy-related hypertensive disorder and is a serious concern in pregnancies. Several factors, including genetic factors (placenta gene expression, and imprinting), oxidative stress, the inaccurate immune response of the mother, and the environmental factors are responsible for PE development, but still, the exact mechanism of the pathogenesis has remained unknown. The main aim of the present study is to identify the gene expression signature in placenta tissue, to unveil disease etiology mechanisms. Read More

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Reduction of serum-induced endothelial STAT3(Y705) activation is associated with preeclampsia.

Pregnancy Hypertens 2021 May 25;25:103-109. Epub 2021 May 25.

Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:

Objectives: Preeclampsia is associated with maternal morbidity and mortality during pregnancy, and also an increased cardiovascular disease (CVD) risk later in life. During preeclampsia, alterations in secreted placental factors leading to systemic maternal endothelial dysfunction are evident. However, little is known about the associated endothelial intracellular signaling. Read More

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Identification and validation of DNA methylation changes in pre-eclampsia.

Placenta 2021 Jun 1;110:16-23. Epub 2021 Jun 1.

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. Electronic address:

Introduction: Pre-eclampsia (PE) is a dangerous placental condition that can lead to premature labour, seizures and death of mother and infant. Several studies have identified altered placental DNA methylation in PE; however, there is widespread inconsistency between studies and most findings have not been replicated. This study aimed to identify and validate consistent differences in methylation across multiple PE cohorts. Read More

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[Natural Selection as a Driver for the Genetic Component of Preeclampsia].

Mol Biol (Mosk) 2021 May-Jun;55(3):441-459

Institute of Medical Genetics, Tomsk National Medical Research Center, Russian Academy of Sciences, Tomsk, 634050 Russia.

Preeclampsia (PE) is a severe hypertensive pathology and affects 2-8% of pregnancies worldwide. Its etiopathogenesis is poorly understood, and prognostic biomarkers and effective treatments are unavailable for this pregnancy complication, determining the high rates of maternal and perinatal morbidity and mortality. Racial and ethnic differences in PE incidence are of interest to study in terms of evolutionary medicine because such variability can be considered as a side effect of adaptive changes that have occurred in the genetic structure of modern populations since the dispersal of Homo sapiens from Africa. Read More

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Modified lung ultrasound scoring system to evaluate the feasibility of pregnant women with COVID-19 pneumonia.

J Matern Fetal Neonatal Med 2021 Jun 6:1-6. Epub 2021 Jun 6.

Department of Ultrasound Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Objective: To investigate whether physicians with short-term training can use a modified lung ultrasound scoring system for coronavirus disease 2019 (COVID-19) pneumonia to assess lung damage in pregnant women.

Methods: Sixteen consecutively hospitalized third-trimester pregnant women with pregnancy-induced hypertension, preeclampsia, rheumatoid arthritis or connective tissue disease were selected as the study subjects for the simulation of COVID-19 pneumonia. Two physicians (imaging and internal medicine) without ultrasonic experience performed lung examinations on pregnant women after six days of lung ultrasound training, and their consistency with examinations by the expert was assessed. Read More

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Association of Angiotensin Receptor Autoantibodies With Cardiovascular Abnormalities in Preeclampsia.

J Am Heart Assoc 2021 Jun 5;10(12):e020831. Epub 2021 Jun 5.

Division of Maternal-Fetal Medicine Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine Baltimore MD.

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CNN-Based LCD Transcription of Blood Pressure From a Mobile Phone Camera.

Front Artif Intell 2021 21;4:543176. Epub 2021 May 21.

Department of Biomedical Informatics, Emory University, Atlanta, GA, United States.

Routine blood pressure (BP) measurement in pregnancy is commonly performed using automated oscillometric devices. Since no wireless oscillometric BP device has been validated in preeclamptic populations, a simple approach for capturing readings from such devices is needed, especially in low-resource settings where transmission of BP data from the field to central locations is an important mechanism for triage. To this end, a total of 8192 BP readings were captured from the Liquid Crystal Display (LCD) screen of a standard Omron M7 self-inflating BP cuff using a cellphone camera. Read More

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Emergency medicine: magnesium sulphate injections and their pharmaceutical quality concerns.

Heliyon 2021 May 22;7(5):e07099. Epub 2021 May 22.

Department of Pharmaceutical Science, North Carolina Central University, Durham, NC, 27707, USA.

Objectives: World Health Organization has recognized magnesium sulphate as the drug of choice for prevention and treatment of fits associated with preeclampsia and eclampsia which are amongst the leading causes of maternal morbidity and mortality. In this study, the pharmaceutical quality of magnesium sulphate injections marketed in Anambra state was assessed.

Methods: Ninety samples of magnesium sulphate obtained from the 3 senatorial zones in Anambra state were subjected to identification tests, microbiological analysis consisting of Growth promotion test, sterility and endotoxin test. Read More

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Does Universal Screening for Gestational Diabetes Mellitus Improve Neonatal Outcomes in a Socially Vulnerable Population: A Prospective Study in French Guiana.

Front Endocrinol (Lausanne) 2021 21;12:644770. Epub 2021 May 21.

Department of Endocrinology and Metabolic Diseases, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Aims/introduction: French Guiana has a high prevalence of metabolic diseases, which are risk factors for gestational diabetes mellitus. Despite routine screening for gestational diabetes, treatment is still challenging because of health inequalities and different cultural representations of disease and pregnancy. This study was conducted to assess the role of early and universal GDM screening on obstetrical and neonatal complications in a socially deprived population. Read More

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