39,667 results match your criteria Preeclampsia and Eclampsia


Are women with a recent diagnosis of pre-eclampsia aware of their cardiovascular disease risk? A cross-sectional survey.

Aust N Z J Obstet Gynaecol 2018 Dec;58(6):E27-E28

School of Health Sciences, Faculty of Health and Medicine, Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Callaghan, New South Wales, Australia.

View Article
December 2018

Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor of Preeclampsia in the period between 20 and 25 Weeks of Gestation.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):757-762. Epub 2018 Dec 7.

Universidade de São Paulo, Ribeirao Preto, SP, Brazil.

Objective:  To evaluate whether the circulating level of tissue inhibitor of metalloproteinase-4 (TIMP-4) in the period between 20 and 25 weeks of gestation is a predictor of preeclampsia.

Methods:  We have performed a case-control study, nested in a prospective study cohort in Ribeirão Preto, in the state of São Paulo, Brazil. Of the 1,400 pregnant women evaluated between 20 and 25 weeks of gestation, 460 delivered in hospitals outside of our institution. Read More

View Article
December 2018

Associations of serum markers screening for Down's syndrome with pregnancy outcomes: A Chinese retrospective cohort study.

Clin Chim Acta 2018 Dec 6. Epub 2018 Dec 6.

Department of Prenatal Diagnosis Laboratory, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, No. 16 Bo Ai Road, Changzhou, Jiangsu Province, China.

Background: We examined the associations between Down's serum screening analytes and pregnancy outcomes in Chinese women.

Methods: A retrospective cohort study of 2470 pregnant women was conducted. Maternal serum triple tests (AFP, fβ-hCG, uE3), maternal characteristics and pregnancy outcomes were recorded from our prenatal screening and hospitalization information system, respectively. Read More

View Article
December 2018

Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats.

Reprod Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Environmental Public Health Division, National Health & Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Read More

View Article
December 2018

LncRNA uc003fir promotes CCL5 expression and negatively affects proliferation and migration of trophoblast cells in preeclampsia.

Pregnancy Hypertens 2018 Oct 17;14:90-96. Epub 2018 Aug 17.

Institute for Fetology, First Hospital of Soochow University, Suzhou, China; Centre for Prenatal Biology, Loma Linda University, CA, USA. Electronic address:

Objective: To evaluate the role of lncRNA uc003fir in the progression and development of preeclampsia (PE).

Design: Paired test using placental tissue collected from PE women and normally pregnant women.

Setting: First Hospital of Soochow University, Suzhou, China. Read More

View Article
October 2018

Long-term follow-up of women with early onset pre-eclampsia shows subclinical impairment of the left ventricular function by two-dimensional speckle tracking echocardiography.

Pregnancy Hypertens 2018 Oct 6;14:9-14. Epub 2018 Jul 6.

Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.

Objectives: This study compares differences in the long-term myocardial function between women with early (EOPE) and late onset preeclampsia (LOPE) and age matched normotensive controls using two-dimensional speckle tracking echocardiography.

Methods: The study population comprised 93 women who gave birth at Department of Gynecology and Obstetrics, Randers Regional Hospital between 1998 and 2008. The women were grouped as EOPE (n = 31), LOPE (n = 22), and women with previous normotensive pregnancies (n = 40). Read More

View Article
October 2018

Prognostic accuracy of cerebroplacental ratio for adverse perinatal outcomes in pregnancies complicated with severe pre-eclampsia; a prospective cohort study.

Pregnancy Hypertens 2018 Oct 21;14:86-89. Epub 2018 Aug 21.

Department of Obstetrics and Gynecology, Marat Ospanov, West Kazakhstan State Medical University, Aktobe, Kazakhstan.

Objective: The current study aims to assess the efficacy of fetal middle cerebral artery/umbilical artery pulsatility index ratio (cerebroplacental ratio CPR) in predicting the occurrence of adverse perinatal outcomes in pregnancies complicated with severe pre-eclampsia.

Materials And Methods: This cohort study included 100 pregnant women between 34 and 40 weeks of gestation attended the labor ward and diagnosed with severe pre-eclampsia. Doppler evaluation was carried out to measure the CPR. Read More

View Article
October 2018

Prospective biomarkers in preterm preeclampsia: A review.

Pregnancy Hypertens 2018 Oct 23;14:72-78. Epub 2018 Mar 23.

NIHR Research Professor in Obstetrics, King's College London. Honorary Consultant Obstetrician, St Thomas' Hospital, London SE1 7EH, UK.

Preterm pre-eclampsia (prior to 37 weeks' gestation) remains a major cause of maternal and fetal morbidity and mortality particularly in low to middle income countries. Much research has focused on first and second trimester predictors of pre-eclampsia with the aim of allowing stratification of antenatal care and trialling of potential preventative and therapeutic agents. However, none have been shown to be of benefit in randomised controlled trials. Read More

View Article
October 2018

Reduced methylation downregulates CD39/ENTPD1 and ZDHHC14 to suppress trophoblast cell proliferation and invasion: Implications in preeclampsia.

Pregnancy Hypertens 2018 Oct 24;14:59-67. Epub 2018 Mar 24.

Obstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. Electronic address:

Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Read More

View Article
October 2018

Glycated haemoglobin A1c as a predictor of preeclampsia in type 1 diabetic pregnant women: A systematic review and meta-analysis.

Pregnancy Hypertens 2018 Oct 7;14:49-54. Epub 2018 Apr 7.

Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.

Objective: To examine the relationship between the increase of glycated haemoglobin A1c (HbA1c) levels and the risk of preeclampsia in pregnant with type 1 diabetes mellitus; and to determine from which trimester the increase of HbA1c levels better predicts the risk of suffering preeclampsia in type 1 diabetic pregnant women.

Methods: We systematically searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews and Web of Science databases, from inception to May 2017, for observational studies addressing the association of HbA1c levels with preeclampsia. Fixed effects models were used to compute pooled estimates of odds ratio (OR) and respective 95% confidence intervals (95% CI) for preeclampsia in type 1 diabetic pregnant women. Read More

View Article
October 2018

Pigment epithelium-derived factor/vascular endothelial growth factor ratio for early prediction of preeclampsia: A prospective multicenter study in China.

Pregnancy Hypertens 2018 Oct 27;14:43-48. Epub 2018 Jul 27.

Department of Clinical Laboratory, Xiangzhou District People's Hospital, Zhuhai, China.

Background: Imbalance of circulating factors related to angiogenesis plays a central role in the pathogenesis of preeclampsia (PE).

Objective: The aim of this study was to discover and validate a cutoff value of pigment epithelium-derived factor (PEDF)/vascular endothelial growth factor (VEGF) ratio for early prediction of PE before 20 weeks of gestation.

Study Design: This prospective multicenter study was performed in mainland China, and was divided into 3 phases to discover, develop, and validate a cutoff value of PEDF/VEGF ratio that could predict PE prior to diagnosis in pregnant women at high risk of PE (12 weeks 0 days to 19 weeks 6 days of gestation). Read More

View Article
October 2018

Predictive value of the sFlt-1 and PlGF in women at risk for preeclampsia in the south of Vietnam.

Pregnancy Hypertens 2018 Oct 27;14:37-42. Epub 2018 Jul 27.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam.

Background: It has been suggested that soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) play potential roles in preeclampsia diagnosis. Nevertheless, studies on the use of sFlt-1, PlGF, and sFlt-1/PlGF ratio in predicting preeclampsia have found contradictory results. Thus, more studies in different populations are needed. Read More

View Article
October 2018

Early-pregnancy weight gain and the risk of preeclampsia: A case-cohort study.

Pregnancy Hypertens 2018 Oct 15;14:205-212. Epub 2018 Oct 15.

Department of Obstetrics & Gynaecology, University of British Columbia, 2329 West Mall, Vancouver, British Columbia V6T 1Z4, Canada.

Objective: To investigate the association between early-pregnancy weight gain and risk of preeclampsia to inform pregnancy weight gain recommendations.

Study Design: We performed a case-cohort study using a hospital database including 80,812 singleton deliveries from Magee-Womens Hospital, Pittsburgh, Pennsylvania (1998-2011). In each of 6 prepregnancy body mass index (BMI) groups, we abstracted serial antenatal weight measurements from the records of up to 339 preeclampsia cases and 1254 randomly selected pregnancies. Read More

View Article
October 2018

Severe hypertension, preeclampsia and small for gestational age in women with chronic hypertension diagnosed before and during pregnancy.

Pregnancy Hypertens 2018 Oct 15;14:200-204. Epub 2018 Oct 15.

Antenatal Hypertension Clinic, Division of Women's Health, Kings College Hospital, Denmark Hill, London SE5 9RS, UK; Harris Birthright Research Centre for Fetal Medicine, Division of Women's Health, Kings College Hospital, Denmark Hill, London SE5 9RS, UK. Electronic address:

Objectives: To compare rates of severe hypertension (SH), preeclampsia (PE) birth of small for gestational age (SGA) neonates between women with chronic hypertension (CH) diagnosed during the first trimester of pregnancy and those with pre-pregnancy CH.

Study Design: Prospective cohort study of women with CH and singleton pregnancies referred to an Antenatal Hypertension Clinic at 8-14 weeks' gestation. At presentation the patients were subdivided into four groups based on blood pressure (BP) control. Read More

View Article
October 2018

Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia - A matched case-control study.

Pregnancy Hypertens 2018 Oct 12;14:195-199. Epub 2018 Oct 12.

Medical University of Vienna, Department of Obstetrics and Gynaecology, Austria.

Objective: Oxidative stress and mitochondrial dysfunction may play a crucial role in preeclampsia (PE). The aim of this study was to investigate differences in maternal levels of serum-mitochondrial (mt) DNA, a proposed biomarker for mitochondrial dysfunction, in women with PE compared to healthy pregnant women.

Study Design: Using samples obtained from the prospective Biobank study, we measured serum-mtDNA levels in pregnant women diagnosed with PE and in women with uneventful pregnancies, matched for gestational and maternal age, BMI, and smoking status. Read More

View Article
October 2018

Functional autoantibodies against Endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia.

Pregnancy Hypertens 2018 Oct 13;14:189-194. Epub 2018 Oct 13.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

Objectives: Functional autoantibodies against Angiotensin II Receptor type 1 (AT1-AA) and Endothelin-1 Receptor type A (ETA-AA), which belong to the class of functional autoantibodies, have been discovered in patients with preeclampsia and in rodent models of pregnancy-induced hypertension. The aim of the study was to investigate the expression of these autoantibodies in relation to disease progression.

Study Design: We included 10 controls and 41 cases defined as patients with gestational-induced hypertension, preeclampsia or HELLP syndrome. Read More

View Article
October 2018

Aspirin use during pregnancy and hypoxia-related placental pathology.

Pregnancy Hypertens 2018 Oct 30;14:177-188. Epub 2018 Jul 30.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathological placental measures in relation to aspirin use during pregnancy. Read More

View Article
October 2018
1 Read

Serum soluble LIGHT in the early third trimester as a novel biomarker for predicting late-onset preeclampsia.

Pregnancy Hypertens 2018 Oct 13;14:174-176. Epub 2018 Oct 13.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan. Electronic address:

Our aim was to evaluate whether serum levels of soluble LIGHT (sLIGHT) at 27-31 weeks can predict the later occurrence of gestational hypertension (GH), late-onset preeclampsia (PE), and early-onset PE. Mean blood pressure (MBP), soluble fma-like tyrosine kinase 1/placental growth factor (sFlt-1/PlGF) ratio at 27-31 weeks, and sLIGHT at 27-31 weeks were independent risk factors for late-onset PE. The combination of the three risk factors improved sensitivity with a false-positive rate of 10% (MBP: 60%, log(sFlt-1/PlGF): 45%, sLIGHT: 35%, combination: 75%). Read More

View Article
October 2018

Prior abortion history and pregnancy hypertensive disorders in primiparous gravidae.

Pregnancy Hypertens 2018 Oct 12;14:168-173. Epub 2018 Oct 12.

Departments of Obstetrics & Gynaecology, The Chinese University of Hong Kong, and Prince of Wales Hospital, Shatin, Hong Kong, China.

Objectives: To explore the relationship between prior abortion history with incidence of pregnancy hypertensive disorders (PHD), including gestational hypertension (GH) and pre-eclampsia (PE), to determine whether the secular increases in GH and PE in developed countries could be related in part to the decreased incidence of abortion.

Study Design: A single center retrospective cohort study on primiparous Chinese gravidae managed in 1997-2015 in our hospital.

Main Outcome Measures: The occurrence of PHD, GH and PE with respect to the presence or otherwise of prior abortions, with the analysis stratified for risk factors that include advanced age, high body mass index (BMI), history of medical disorders, birth before 34 weeks, and maternal hepatitis B virus (HBV) infection and rubella non-immunity which have been shown to influence the occurrence of PHD in our population. Read More

View Article
October 2018

Clinical features and outcomes of pregnancies complicated by pre-ecplampsia necessitating in-utero transfer.

Pregnancy Hypertens 2018 Oct 2;14:162-167. Epub 2018 Oct 2.

The University of Melbourne, Department of Obstetrics and Gynaecology, Melbourne, Australia; Paediatric Infant Perinatal Emergency Retrieval, Royal Children's Hospital, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Objectives: Pre-eclampsia (PE) is associated with significant risks of adverse perinatal outcomes, often necessitating transfer to a higher level of care for specialist perinatal management. In Victoria, Australia, the Paediatric Infant Perinatal Emergency Retrieval (PIPER) coordinates in-utero transfers of high-risk pregnancies. Our objectives were to report the clinical features and outcomes of women referred to PIPER with a primary diagnosis of PE, and subsequently transferred in-utero. Read More

View Article
October 2018

Recurrence rates of preeclampsia over the past 20 years in women assessed for non-pregnant cardiovascular risk factors.

Pregnancy Hypertens 2018 Oct 22;14:150-155. Epub 2018 Sep 22.

Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, the Netherlands. Electronic address:

Objective: Several efforts to reduce recurrent preeclampsia have been implemented in clinical practice in the past decades. We assessed whether recurrence rates of preeclampsia and related offspring complications decreased in the past 20 years in women who received tailored preventive advices.

Study Design: In this observational cohort study, we included 752 women who had their first pregnancy complicated by preeclampsia between 1996 and 2012, and who participated in a non-pregnant risk factor assessment. Read More

View Article
October 2018

The relationship between DNA repair genes (XPA, XPF, XPG) polymorphism and the risk of preeclampsia in Chinese Han Women.

Pregnancy Hypertens 2018 Oct 2;14:145-149. Epub 2018 Oct 2.

Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Our study aimed to investigate the association between polymorphism of three core genes belonging to NER pathway and preeclampsia (PE) risk in Chinese Han Women. The DNA used in our experiment was extracted from 1004 cases and 1274 normal pregnant women. All single nucleotide polymorphisms (SNPs) were analyzed with TaqMan allelic discrimination real-time PCR. Read More

View Article
October 2018

Impact of obesity on the association of active renin and plasma aldosterone concentrations, and aldosterone-to-renin ratio with preeclampsia.

Pregnancy Hypertens 2018 Oct 27;14:139-144. Epub 2018 Sep 27.

INSERM UMR-S1139 College of Pharmacy, Paris Descartes University, France; Department of Biological Endocrinology, CHU Cochin, AP-HP, Paris, France. Electronic address:

Objective: To evaluate the association of active renin concentration (ARC), plasma aldosterone concentration (PAC) and aldosterone-to-renin ratio (ARR) with the risk of preeclampsia (PE), in particular according to the status of obesity.

Design: This retrospective case-control study involved 90 women with PE (mean gestation 35.6 ± 3. Read More

View Article
October 2018

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.

Pregnancy Hypertens 2018 Oct 21;14:125-130. Epub 2018 Sep 21.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia.

Preeclampsia is associated with intermittent placental hypoxia, inflammation and the release of antiangiogenic factors, namely sFLT-1 and sEng. These factors cause maternal endothelial dysfunction and the manifestation of clinical disease. Disulfiram is a dehydrogenase inhibitor used to treat alcoholism and has been suggested as a proteasome inhibitor. Read More

View Article
October 2018

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia.

Pregnancy Hypertens 2018 Oct 5;14:115-120. Epub 2018 Sep 5.

Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, 163 Studley Road, Heidelberg 3084, Victoria, Australia. Electronic address:

Introduction: Preeclampsia is a severe complication of pregnancy, and likely arises from abnormal placental development in early pregnancy. Persistent placental hypoxia is thought to trigger the release of anti-angiogenic factors into the maternal circulation leading to widespread endothelial dysfunction. Epidermal growth factor-like domain 7 (EGFL7) is a secreted angiogenic factor that may play a key role in the disrupted angiogenesis seen in response to placental hypoxia that characterizes preeclampsia. Read More

View Article
October 2018

Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension.

Pregnancy Hypertens 2018 Oct 5;14:110-114. Epub 2018 Sep 5.

Section of Maternal Fetal Medicine/Department of Obstetrics & Gynecology, University of Chicago, Chicago, IL, USA. Electronic address:

Background: Angiogenic factors have been implicated in the pathogenesis of preeclampsia. This pilot study explored the association between antenatal blood pressure levels and angiogenic biomarkers (sFlt1 and PlGF) among women with chronic hypertension (cHTN).

Methods: Blood samples were collected from women with cHTN (with/without superimposed preeclampsia) within 96 h prior to delivery. Read More

View Article
October 2018
1 Read

Risk of eclampsia or HELLP-syndrome by institution availability and place of delivery - A population-based cohort study.

Pregnancy Hypertens 2018 Oct 21;14:1-8. Epub 2018 Jun 21.

Department of Global Public Health and Primary Care, University of Bergen, Norway; Division of Health Data and Digitalisation, The Norwegian Institute for Public Health, Bergen, Norway.

Objective: To examine the association between availability of obstetric institutions and risk of eclampsia, HELLP-syndrome, or delivery before 35 gestational weeks in preeclamptic pregnancies.

Study Design: National population-based retrospective cohort study of deliveries in Norway, 1999-2009 (n = 636738) using data from The Medical Birth Registry of Norway and Statistics Norway. Main exposures were institution availability, measured by travel time to the nearest obstetric institution, and place of delivery. Read More

View Article
October 2018
1 Read

Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

View Article
December 2018
2 Reads

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

View Article
December 2018
2 Reads

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

View Article
November 2018
6 Reads

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

View Article
December 2018
1 Read

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

View Article
November 2018

Brachial and uterine arteries Doppler in healthy women and with preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):360-363. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", División de Investigación en Salud. Ciudad de México, México

Objective: To compare the Doppler ultrasound parameters of the uterine and brachial arteries, between healthy pregnant women and pregnant women with preeclampsia.

Methods: 102 pregnant women were studied in the third trimester, group I 83 healthy women and group II 19 patients with severe preeclampsia. All of them underwent Doppler ultrasound of the uterine arteries, measuring the pulsatility index (PI) and determining the presence of proto-diastolic notch. Read More

View Article
November 2018

Taming preeclampsia at its source.

Nat Biotechnol 2018 Dec;36(12):1151-1152

Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.

View Article
December 2018

Assessing the effect of dexmedetomidine in patients with pre-eclampsia.

Eur J Anaesthesiol 2019 Jan;36(1):75

From the Department of Anaesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (BH, XZ, JS), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article
January 2019

Profound bilateral post-partum retinal circulation ischemia in two diabetic mothers with pre-eclampsia.

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

View Article

Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

Chymase is a major angiotensin-converting enzyme (ACE)-independent angiotensin convertase, and its expression is upregulated in the maternal vascular endothelium in preeclampsia, a hypertensive disorder in human pregnancy. Increased chymase-dependent angiotensin II generation has been reported in several cardiovascular diseases, including atherosclerosis and aneurysmal lesions. However, it remains unclear how chymase is activated. Read More

View Article
December 2018

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Epidemiology, University of Iowa, Iowa City, IA, USA.

Objective: Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.

Study Design: A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Read More

View Article
December 2018

Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.

Am J Case Rep 2018 Dec 6;19:1445-1448. Epub 2018 Dec 6.

Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

BACKGROUND Levo-transposition of the great arteries (L-TGA) is a rare form of congenital heart disease that may go unrecognized until adulthood. Parturient women with L-TGA have a high likelihood of developing acute pulmonary edema and cardiac dysrhythmias during the peri-partum period. CASE REPORT We present the case of a 32-year-old primigravida patient with previously unknown diagnosis of L-TGA, presenting with preeclampsia, whose peri-partum course was complicated by the development of acute pulmonary edema, complete heart block, and acute hypoxic respiratory failure. Read More

View Article
December 2018

Application of iTRAQ proteomics in identification of the differentially expressed proteins of placenta of pregnancy with preeclampsia.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Wuxi Matemal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Objective: To explore the differential protein profile of preeclampsia and identify its potential biomarker.

Methods: Around 20 pregnant women with preeclampsia (preeclampsia group) and 20 normal-term pregnancy (normal group) were collected from 2017 to 2018 in the study. Total protein of placenta tissues was extracted, denaturized, deoxidized, and enzymolyzed. Read More

View Article
December 2018

Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12.

Acta Paediatr 2018 Dec 1. Epub 2018 Dec 1.

Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.

Aim: We examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12-year-old offspring.

Methods: This secondary analyses of a prospective mother-child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, The Netherlands. Read More

View Article
December 2018

Placental thickness on ultrasound and neonatal birthweight.

J Perinat Med 2018 Dec 3. Epub 2018 Dec 3.

Penn State Hershey Medical Center, Division of Maternal Fetal Medicine, Hershey, PA, USA.

Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. Read More

View Article
December 2018

High Sensitivity Cardiac Troponin I Levels in Normal Pregnancy And When Complicated By Hypertension.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: To examine the association of circulating concentrations of high-sensitivity cardiac troponin I (hs-Tn) in the various trimesters of pregnancy in patients with and without hypertension.

Method: Prospective cross-sectional study of pregnant and post-natal women aged between 18-35 years of age with no coexisting disease. Serum samples were analysed for hs-TnI. Read More

View Article
November 2018
3 Reads

Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.

Cell 2018 Nov 20. Epub 2018 Nov 20.

Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Preeclampsia is the most frequent pregnancy-related complication worldwide with no cure. While a number of molecular features have emerged, the underlying causal mechanisms behind the disorder remain obscure. Here, we find that increased complex formation between angiotensin II AT1 and bradykinin B2, two G protein-coupled receptors with opposing effects on blood vessel constriction, triggers symptoms of preeclampsia in pregnant mice. Read More

View Article
November 2018

Early screening for gestational diabetes mellitus is not associated with improved pregnancy outcomes: an observational study including 9795 women.

Diabetes Metab 2018 Nov 28. Epub 2018 Nov 28.

Paris 13 university, Sorbonne Paris Cité, AP-HP, Jean-Verdier hospital, department of obstetrics and gynecology, Bondy, France.

Aims: In addition to screening for hyperglycaemia during pregnancy after 24 weeks of gestation (WG), the current guidelines also suggest screening in early pregnancy and referring women with early gestational diabetes mellitus (eGDM) or overt diabetes (OD) for immediate care. Our aim was to evaluate this strategy.

Methods: This study evaluated, at our hospital (2012-2016), whether the incidence of a predefined composite outcome (preeclampsia, large-for-gestational-age infant, shoulder dystocia) and secondary outcomes was different when women were screened only after 22WG ('late screening only') or before 22WG and treated for eGDM or OD if present, with repeat screening after 22WG if absent ('early ± late screening'). Read More

View Article
November 2018

Placental inflammation by HMGB1 activation of TLR4 at the syncytium.

Placenta 2018 Dec 2;72-73:53-61. Epub 2018 Nov 2.

Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. Electronic address:

Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal circulation. Activation of toll-like receptors (TLR)2 and TLR4 by endogenous danger signals plays a role in inflammatory diseases. Read More

View Article
December 2018
1 Read

Effects of consuming sugars and alternative sweeteners during pregnancy on maternal and child health: evidence for a secondhand sugar effect.

Proc Nutr Soc 2018 Dec 3:1-10. Epub 2018 Dec 3.

Department of Preventive Medicine,University of Southern California Health Sciences Campus,2250 Alcazar Street, Los Angeles, CA 90033,USA.

Consumption of sugar and alternative low- or no-energy sweeteners has increased in recent decades. However, it is still uncertain how consumption of sugar and alternative sweeteners during pregnancy affects pregnancy outcomes and long-term offspring health. This review aims to collate the available evidence surrounding the consequences of sugar and alternative sweetener consumption during pregnancy, a so-called secondhand sugar effect. Read More

View Article
December 2018
1 Read

Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy.

J Matern Fetal Neonatal Med 2018 Dec 2:1-7. Epub 2018 Dec 2.

a Department of Perinatology and Gynecology , Poznan University of Medical Sciences , Poznań , Poland.

Introduction: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis.

Objective: The aim of this study was to investigate the relationship between endocan serum levels and various types of hypertensive disorders in pregnant women.

Patients And Methods: We created three study groups (preeclampsia [n = 60], chronic hypertension [n = 39], gestational hypertension [n = 58]) and the control group consisting of 59 healthy pregnant women. Read More

View Article
December 2018
1 Read

Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy.

Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy.

Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Read More

View Article
December 2018
0.489 Impact Factor

Components of the antepartum, intrapartum, and postpartum exposome impact on distinct short-term adverse neonatal outcomes of premature infants: A prospective cohort study.

PLoS One 2018 5;13(12):e0207298. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United states of America.

We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131). Newborns (n = 372) were followed until death or discharge. Read More

View Article
December 2018
1 Read