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Pregnancy Hypertens 2022 May 10;28:168-173. Epub 2022 May 10.

Santa Casa de Misericórdia of Pará, Belém, PA, Brazil.

Objective: To evaluate the prevalence of preeclampsia among cases of COVID-19 infection during pregnancy and the association between both conditions, in a multicenter cohort of Brazilian women with respiratory symptoms.

Study Design: Ancillary analysis of the Brazilian Network of COVID-19 in Obstetrics (REBRACO) study. We performed a nested case-control analysis selecting all women with COVID-19 and compared outcomes between women with and without PE. Read More

Int J Environ Res Public Health 2022 Apr 23;19(9). Epub 2022 Apr 23.

Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-813 Warsaw, Poland.

Placental abruption (PA) is a separation of the placenta from the uterine wall occurring with the fetus still present in the uterine cavity. It contributes to numerous neonatal and maternal complications, increasing morbidity and mortality. We conducted a retrospective study at a tertiary perinatal care center, which included 2210 cases of labor that took place in 2015 with a PA occurrence of 0. Read More

Cells 2022 May 5;11(9). Epub 2022 May 5.

Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.

Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. Likewise, maternal obesity has also increased worldwide over the past several years. Read More

BMC Pregnancy Childbirth 2022 May 13;22(1):407. Epub 2022 May 13.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Science and Medicine, Kings College London, London, UK.

Background: Iron-deficiency anemia is a known risk factor for several adverse perinatal outcomes, but data on its impact on specific maternal morbidities is less robust. Further, information on associations between anemia in early pregnancy and subsequent outcomes are understudied.

Methods: The study population was derived from the Community Level Interventions for Pre-eclampsia (CLIP) trial in Karnataka State, India (NCT01911494). Read More

Hum Reprod 2022 May 13. Epub 2022 May 13.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.

Study Question: Is there an association between the different endometrial preparation protocols for frozen embryo transfer (FET) and obstetric and perinatal outcomes?

Summary Answer: Programmed FET protocols were associated with a significantly higher risk of hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), post-partum hemorrhage (PPH) and cesarean section (CS) when compared with natural FET protocols.

What Is Known Already: An important and growing source of concern regarding the use of FET on a wide spectrum of women, is represented by its association with obstetric and perinatal complications. However, reasons behind these increased risks are still unknown and understudied. Read More

Ann Med 2022 Dec;54(1):1350-1356

Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Lublin, Poland.

MicroRNAs (miRNAs) are a class of small non-coding, single-stranded RNAs (ribonucleic acids) that play important roles in many vital processes through their impact on gene expression. One such miRNA, miR210, represents a hypoxia-induced cellular miRNA group that hold a variety of functions. This review article highlights the importance of miR-210 in the development of pre-eclampsia. Read More

Placenta 2022 May 2;123:32-40. Epub 2022 May 2.

Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland; Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Switzerland. Electronic address:

Introduction: In pregnancy, aldosterone is linked to maternal plasma volume expansion, improved fetal and placental growth/angiogenesis and reduced maternal blood pressure. Aldosterone levels are low in women with pre-eclampsia. Given the placental growth properties of aldosterone in pregnancy, we hypothesised that increased aldosterone improves placental function ex vivo. Read More

Cell Mol Life Sci 2022 May 10;79(6):290. Epub 2022 May 10.

Center of Reproductive Medicine, State Key Laboratory of Reproductive Medicine, Research Institute for Reproductive Health and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, China.

Maternal cellular and humoral immune responses to the allogeneic fetoplacental unit are a normal part of pregnancy adaptation. Overactive or dysregulated immune responses that often manifest as inflammation are considered a key element for the development of preeclampsia. Infiltration and activation of macrophages, nature killer cells, and T lymphocytes are frequently observed in the decidua and placenta associated with preeclampsia. Read More

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1397-1406

Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Proteinuria can range from subnephrotic to nephrotic amounts during pregnancy, though nephrotic syndrome (NS) is rare (0.012%-0.025%). Read More

Arch Clin Cases 2022 6;9(1):24-28. Epub 2022 Apr 6.

CMH Lahore Medical College, Lahore, Punjab, Pakistan.

We report a case of thrombotic microangiopathy in a postpartum female for which considerable diagnostic uncertainty existed initially regarding the etiology. This case highlights the limitations surrounding PLASMIC scoring criteria for the diagnosis of thrombotic thrombocytopenic purpura (TTP). A 32-year-old woman presented to maternofetal medicine in her third trimester of pregnancy at 32 weeks for a routine follow up and was subsequently found to have elevated blood pressures with proteinuria, and was diagnosed with pre-eclampsia. Read More

J Immunol Res 2022 28;2022:2373694. Epub 2022 Apr 28.

Department of Obstetrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

Preeclampsia remains a high cause of incidence and death for mothers and fetuses in developing nations. Preeclampsia has numerous clinical and biochemical markers that have been tested, but they have failed to provide a conclusive diagnosis in the different phases of the disease's progression. Herein, our team intended to determine potential diagnostic biomarkers for preeclampsia and analyzed associations with immune cells. Read More

Lancet 2022 05;399(10337):1809

Department of Medicine, Division of Endocrinology, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Arch Gynecol Obstet 2022 May 7. Epub 2022 May 7.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Pavilion H, Room 325, 5790 Cote-des-Neiges Road, Montreal, H3S 1Y9, Canada.

Purpose: With improvement in cancer care and fertility preservation, increasing numbers of cancer survivors are requiring obstetrical care. The objective of our study was to evaluate the effect of history of chemotherapy exposure on maternal and neonatal outcomes.

Methods: A retrospective population-based cohort study was conducted using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) to obtain data on maternal and newborn outcomes in a cohort of births occurring between the years 2006 and 2015. Read More

Rom J Intern Med 2022 May 6. Epub 2022 May 6.

Nephrology, Pulmonary and Critical Care Medicine Department. WellStar Health System. Marietta GA, USA.

. Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study. Read More

Kardiol Pol 2022 May 6. Epub 2022 May 6.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

Pregnancy complications including severe maternal morbidity have been linked with an increased risk of cardiovascular disease and provide opportunities to identify women who would benefit from prevention. Severe maternal morbidity comprises life endangering complications around the time of pregnancy and delivery. Literature on the relationship between severe maternal morbidity and cardiovascular disease is increasing at a rapid pace. Read More

Br J Nutr 2022 May 6:1-8. Epub 2022 May 6.

Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou450052, People's Republic of China.

Little is known about the effects of dietary patterns on prevalent pre-eclampsia in Chinese population. This study aimed to investigate the associations between dietary patterns and the odds of pre-eclampsia among Chinese pregnant women. A 1:1 age- and gestational week-matched case-control study was conducted between March 2016 and February 2019. Read More

BMC Med Genomics 2022 05 5;15(1):103. Epub 2022 May 5.

Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 216 Huansha Road, Hangzhou, 310006, Zhejiang, China.

Background: This is the first study to explore the potential functions and expression patterns of RNA N6-methyladenosine (m6A) and potential related genes in preeclampsia.

Methods: We identified two m6A modification patterns through unsupervised cluster analysis and validated them by principal component analysis. We quantified the relative abundance of specific infiltrating immunocytes using single-sample gene set enrichment analysis (ssGSEA) and the Wilcoxon test. Read More

Expert Rev Clin Immunol 2022 May 10:1-13. Epub 2022 May 10.

Independent Researcher, Past Director Nephrology Policlinico, Milan, Italy.

Introduction: Women with systemic lupus erythematosus (SLE), particularly those with lupus nephritis (LN), remain at high risk for adverse pregnancy outcome. Although in the last decades maternal and fetal outcomes have improved dramatically, preeclampsia remains a major cause of maternal and perinatal morbidity and mortality.

Areas Covered: A narrative review of literature was conducted, underlying the importance of pre-conception counseling, and focusing on the correlation between preeclampsia and LN. Read More

Rev Panam Salud Publica 2022 2;46:e21. Epub 2022 May 2.

Facultad de Ciencias de la Salud Universidad de Talca Talca Chile Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile.

Objective: To estimate the point prevalence and likely ranges of pregnancy-induced hypertension, pre-eclampsia, gestational diabetes, low birth weight and preterm delivery in Latin America and the Caribbean, and evaluate the heterogeneity of the estimates.

Methods: We conducted a systematic review and meta-analysis of observational studies reporting the prevalence of maternal and perinatal adverse outcomes in populations in Latin American and the Caribbean published between 2000 and 2019 in English, Spanish, or Portuguese. We searched PubMed, Embase, and LILACS. Read More

Mol Med 2022 May 4;28(1):51. Epub 2022 May 4.

Department of Gynecology and Obstetrics, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly understood and only few platelet-based markers have been investigated. In sepsis, platelet mitochondrial membrane depolarization, a sensitive and early indicator of mitochondrial dysfunction and platelet cell death, correlates with disease severity and outcome as shown in previous studies. Read More

Eur J Clin Pharmacol 2022 May 4. Epub 2022 May 4.

Department of Epidemiology, Regional Health Service, ASL Roma 1, Rome, Lazio, Italy.

Purpose: Infertility is a topic of growing interest, and female infertility is often treated with gonadotropins. Evidence regarding comparative safety and efficacy of different gonadotropin formulations is available from clinical studies, while real-world data are missing. The present study aims to investigate effectiveness and safety of treatment with different gonadotropin formulations in women undergoing medically assisted procreation treatments in Latium, a region in central Italy, through a real-world data approach. Read More

Bioengineered 2022 May;13(5):11456-11470

Department of Obstetrics, Longhua District Maternity and Child Health Hospital, Shenzhen, Guangdong, China.

Pre-eclampsia (PE) is a prevalent pregnancy disease characterized by insufficient trophoblast cell migration (HTR8/SVneo). Consequently, accelerating trophoblast cell proliferation might ameliorate PE. This study assessed the effects and molecular mechanisms of Sufentanil (SUF) on HTR8/SVneo cells proliferation. Read More

Cureus 2022 Apr 1;14(4):e23724. Epub 2022 Apr 1.

Internal Medicine, Manipal College of Medical Sciences, Pokhara, NPL.

Hepatic infarction is uncommon due to the dual blood supply from the hepatic artery and portal vein. The majority of the cases are caused following liver transplant or hepatobiliary surgery, hepatic artery occlusion, or shock. Hepatic infarction is a rare complication of hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. Read More

Cureus 2022 Mar 30;14(3):e23659. Epub 2022 Mar 30.

Anesthesiology, Brooke Army Medical Center, Fort Sam Houston, USA.

Posterior reversible encephalopathy syndrome (PRES) is a rare neurologic disorder that has recently become more frequently diagnosed. While the exact etiology of PRES remains unclear, multiple diseases are associated with PRES. Moreover, there is increasing recognition of the association of PRES in pre-eclampsia/eclampsia with advancements in imaging techniques and increased awareness of the disorder. Read More

Adv Exp Med Biol 2022 ;1360:101-108

Nephrology and Hypertension Institute, Sheba Medical Center, Tel-Aviv University, Ramat Gan, Israel.

Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune activation, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Read More

Am J Obstet Gynecol 2022 Apr 30. Epub 2022 Apr 30.

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center.

Objective: Migraine affects 28% of women in their pregnancy-capable years, and is associated with systemic inflammation, endothelial dysfunction, and increased risk of pregnancy-associated thromboembolic events. Migraine history has been associated with adverse pregnancy outcomes (APO) of placental origin, including hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). We tested the hypothesis that self-reported migraine in nulliparous individuals is associated with higher odds of APO. Read More

JAMA 2022 05;327(17):1700-1701

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

JAMA 2022 05;327(17):1656-1665

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Importance: Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring of BP in the general population has been shown to improve the diagnosis and management of hypertension; however, little is known about its use in pregnancy.

Objective: To determine whether self-monitoring of BP in higher-risk pregnancies leads to earlier detection of pregnancy hypertension. Read More

JAMA 2022 05;327(17):1666-1678

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Importance: Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role of blood pressure self-monitoring in pregnancy in improving clinical outcomes for the pregnant individual and infant is unclear.

Objective: To evaluate the effect of blood pressure self-monitoring, compared with usual care alone, on blood pressure control and other related maternal and infant outcomes, in individuals with pregnancy hypertension. Read More

Rev Colomb Obstet Ginecol 2022 03 30;73(1):48-141. Epub 2022 Mar 30.

Instituto de Evaluación de Tecnologías en Salud e Investigación - IETSI, EsSalud, Lima (Perú)..

Objectives: To provide clinical recommendations based on evidence for the the prevention and management of HDP in EsSalud. Methods: A CPG for the the prevention and management of HDP in EsSalud was developed. To this end, a guideline development group (local GDG) was established, including medical specialists and methodologists. Read More