40,088 results match your criteria Preeclampsia


The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 15. Epub 2019 Feb 15.

Institute of Biomedical Sciences, Department of Cell and Developmental Biology, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Endoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been described in several human pathologies, including cancer and neurological disorders, and in some gestational diseases such as preeclampsia and gestational diabetes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.012DOI Listing
February 2019

Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.

FASEB J 2019 Feb 18:fj201802058RR. Epub 2019 Feb 18.

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China.

Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast cells. Abnormal functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset preeclampsia. Read More

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http://dx.doi.org/10.1096/fj.201802058RRDOI Listing
February 2019

Obstructive sleep apnoea in multiple pregnancy.

Aust N Z J Obstet Gynaecol 2019 Feb 17. Epub 2019 Feb 17.

Department of Respiratory and Sleep Disorders Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Obstructive sleep apnoea (OSA) during pregnancy has been associated with gestational diabetes mellitus, hypertension and low birth weight. Multiple pregnancy is associated with similar adverse perinatal outcomes. Multiple pregnancy rates have risen with increased access to assisted conception; simultaneously, advancing maternal age and weight are also driving a rise in the incidence of OSA in pregnancy. Read More

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http://dx.doi.org/10.1111/ajo.12958DOI Listing
February 2019

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery.

Placenta 2019 Feb 12. Epub 2019 Feb 12.

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops discussed new perspectives and knowledge in the following areas of research: 1) preeclampsia; 2) abnormally invasive placenta; 3) placental infection; 4) gestational trophoblastic disease; 4) drug delivery to treat placental dysfunction. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.006DOI Listing
February 2019

A retrospective study on evaluation of anti-hypertensive drugs used in gestational hypertension.

Pak J Pharm Sci 2019 Jan;32(1):213-215

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Read More

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January 2019

Circulating lncRNA BC030099 Increases in Preeclampsia Patients.

Mol Ther Nucleic Acids 2019 Feb 1;14:562-566. Epub 2019 Feb 1.

Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Long noncoding RNAs (lncRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence demonstrates that circulating lncRNAs can be used as diagnostic biomarkers. Therefore, the purpose of this study was to evaluate the potential for circulating lncRNAs as novel biomarkers for the diagnosis of preeclampsia. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.011DOI Listing
February 2019

The European registry on obstetric Antiphospholipid syndrome (EUROAPS): A survey of 1000 consecutive cases.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.

Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS).

Methods: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.006DOI Listing
February 2019

Enhanced type I interferon gene signature in primary antiphospholipid syndrome: Association with earlier disease onset and preeclampsia.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo (USP), Brazil.

Objective: Recently, two studies demonstrated that a relevant percentage of primary antiphospholipid syndrome (PAPS) patients had an upregulation of interferon (IFN) genes. However, 20%-28% of these patients had anti-dsDNA, a highly specific systemic lupus erythematosus (SLE) autoantibody. This study aimed to determine the prevalence of the type I IFN signature in the peripheral blood mononuclear cells of PAPS patients without specific SLE autoantibodies and search for its clinical associations. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.11.004DOI Listing
February 2019

Primary and secondary prevention of preterm birth: a review of systematic reviews and ongoing randomized controlled trials.

Eur J Obstet Gynecol Reprod Biol 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, Dalhousie University, Halifax Nova Scotia, Canada.

Background: Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality. Interventions aimed at preventing PTB can be classified as primary, secondary, or tertiary prevention.

Objective: To conduct a review of systematic reviews on the effectiveness and safety of primary and secondary preterm birth prevention interventions. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.022DOI Listing
January 2019

Agonistic autoantibodies against B2-adrenergic receptors correlating with macrovascular disease in longstanding diabetes type 2.

Acta Diabetol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine III, Jena University Hospital, Jena, Germany.

Aims: Agonistic autoantibodies directed against adrenergic, endothelin, and angiotensin receptors are known as pathogenic factors in disease-causing vascular impairments such as Buergers' disease, dilatative cardiomyopathy, dementia, and preeclampsia. Diabetes mellitus also causes micro- and macrovascular damages, but pathogenesis is still not fully understood. Following indications for a pathogenic role of the mentioned antibodies from our preliminary investigations, we investigated the prevalence in a bigger cohort of patients with longstanding diabetes with or without diabetic complications. Read More

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http://dx.doi.org/10.1007/s00592-019-01296-8DOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019
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Maternal preeclampsia and respiratory outcomes in extremely premature infants.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Preeclampsia (PE) is a pregnancy complication characterized by an anti-angiogenic environment. This can affect fetal pulmonary vascular and alveolar development but data of the impact of PE on respiratory outcome in extremely premature infants are inconclusive.

Objective: To determine if PE is associated with an increased risk for severe respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in extremely premature infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0336-5DOI Listing
February 2019
1 Read

A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks.

J Clin Endocrinol Metab 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynaecology, NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Context: Previous studies have shown reduced placental levels of 11-beta-hydroxysteroid dehydrogenase-type 2 (11βHSD2) in preeclampsia. However, it is not known if the maternal cortisol to cortisone ratio is predictive of placental complications of pregnancy.

Objective: To determine the relationship between the maternal serum cortisol to cortisone ratio at different stages of pregnancy and the risk of preeclampsia or fetal growth restriction (FGR). Read More

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http://dx.doi.org/10.1210/jc.2018-02312DOI Listing
February 2019

How can we make pregnancy safe for women with Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 Feb 15. Epub 2019 Feb 15.

Endocrinology Department, Saint Antoine Hospital, Centre de Référence des Maladies Endocrines Rares de la Croissance, Filière FIRENDO, ENDO-ERN, Paris, France.

Pregnancy is a crucial issue in patients with Turner syndrome (TS). Although natural pregnancies have been reported in 4-7% of TS patients, most women will need assisted reproductive technologies (ART) with oocyte donation. The main issue is the maternal mortality rate that is higher than in the general population. Read More

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http://dx.doi.org/10.1002/ajmg.c.31682DOI Listing
February 2019

Placental location and pregnancy outcomes in nulliparous women: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.

Introduction: The impact of placenta previa on pregnancy, delivery and infant outcomes has been extensively studied. Less is however known about the possible association of placental location other than previa with pregnancy outcomes. The aim of this study was to investigate if placental location other than previa is associated with adverse pregnancy, delivery and infant outcomes. Read More

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http://dx.doi.org/10.1111/aogs.13578DOI Listing
February 2019

Pregnancy Outcomes in Women with Strictly Controlled Type 1 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):798-800

Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.

Objective: To evaluate the pregnancy outcomes in mothers with controlled Type 1 diabetes mellitus (T1DM).

Materials And Methods: Thirty seven pregnant patients with controlled T1DM were included in the study.

Results: Twenty (54%) out of 37 patients had preterm delivery (<37 weeks of gestation). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330866PMC
February 2019

Rosiglitazone blocks first trimester in-vitro placental injury caused by NF-κB-mediated inflammation.

Sci Rep 2019 Feb 14;9(1):2018. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.

Increased inflammation and abnormal placentation are common features of a wide spectrum of pregnancy-related disorders such as intra uterine growth restriction, preeclampsia and preterm birth. The inflammatory response of the human placenta has been mostly investigated in relation to cytokine release, but the direct molecular consequences on trophoblast differentiation have not been investigated. This study measured the general effects of LPS on both extravillous and villous trophoblast physiology, and the involvement of the transcription factors PPARγ and NF-κB, specifically using 1 trimester explants and HTR-8/ SVneo cell line models. Read More

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http://dx.doi.org/10.1038/s41598-018-38336-2DOI Listing
February 2019

NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase.

Exp Mol Med 2019 Feb 15;51(2):17. Epub 2019 Feb 15.

Departments of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Gangwon-do, 24341, South Korea.

Vascular smooth muscle cells (VSMCs) play an important role in maintaining vascular function. Inflammation-mediated VSMC dysfunction leads to atherosclerotic intimal hyperplasia and preeclamptic hypertension; however, the underlying mechanisms are not clearly understood. We analyzed the expression levels of microRNA-155 (miR-155) in cultured VSMCs, mouse vessels, and clinical specimens and then assessed its role in VSMC function. Read More

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http://dx.doi.org/10.1038/s12276-019-0212-8DOI Listing
February 2019

The placenta: A site of end-organ damage after Fontan operation. A case series.

Int J Cardiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL, United States of America.

Background: Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology.

Methods: We reviewed clinical charts and placental pathology from 7 women with Fontan physiology who had pregnancies at Mayo Clinic, Rochester, Minnesota. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.002DOI Listing
February 2019

Optic nerve ultrasonography for evaluating increased intracranial pressure in severe preeclampsia.

Int J Obstet Anesth 2019 Jan 6. Epub 2019 Jan 6.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1016/j.ijoa.2018.12.010DOI Listing
January 2019

Reply: Optic nerve ultrasonography for evaluating increased intracranial pressure in severe preeclampsia.

Int J Obstet Anesth 2019 Jan 6. Epub 2019 Jan 6.

Department of Cardiology, University Medical Center Ljubljana, Slovenia.

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http://dx.doi.org/10.1016/j.ijoa.2018.12.009DOI Listing
January 2019

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.

J Am Heart Assoc 2019 Feb;8(4):e010647

1 Division of Nephrology & Hypertension Mayo Clinic Rochester MN.

Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial dysfunction and activation. Methods and Results We examined the sublingual glycocalyx noninvasively using sidestream dark field imaging in the third trimester among women with normotensive pregnancies (n=73), early (n=14) or late (n=29) onset preeclampsia, or gestational diabetes mellitus (n=21). Read More

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http://dx.doi.org/10.1161/JAHA.118.010647DOI Listing
February 2019

The ability of thromboelastography parameters to predict severe pre-eclampsia when measured during early pregnancy.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: To examine the predictive value of thromboelastography parameters during early pregnancy as potential markers of severe pre-eclampsia during late pregnancy.

Methods: An observational retrospective case-control study was conducted among pregnant women who attended a single hospital in Shanghai, China, between July 1, 2016, and February 31, 2018. Data were obtained from medical records and a structured questionnaire completed by the participants. Read More

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http://dx.doi.org/10.1002/ijgo.12785DOI Listing
February 2019

Otalgia, Preeclampsia, Latent Tuberculosis, Pityriasis Rosea, Extremity Pain.

Authors:

Am Fam Physician 2019 Feb;99(4):226

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February 2019

Aggravation of atrial arrhythmia by amiodarone during the perinatal period: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14466

Department of Cardiology, Wenzhou People's Hospital, Wenzhou Third Clinical Institute Affiliated with Wenzhou Medical University, Wenzhou, Zhejiang, China.

Rationale: Amiodarone, a broad-spectrum antiarrhythmic drug, is widely used for the clinical treatment of tachyarrhythmias because of its safety and efficacy.

Patient Concerns: A 30-year-old woman presented with known paroxysmal atrial tachycardia and severe preeclampsia. Two days before admission, she had given birth to twins. Read More

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http://dx.doi.org/10.1097/MD.0000000000014466DOI Listing
February 2019

Discovery of Pathologic GPCR Aggregation.

Front Med (Lausanne) 2019 30;6. Epub 2019 Jan 30.

Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. Read More

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http://dx.doi.org/10.3389/fmed.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363654PMC
January 2019

Small for gestational age infants and the association with placental and umbilical cord morphometry: a digital imaging study.

J Matern Fetal Neonatal Med 2019 Feb 13:1-171. Epub 2019 Feb 13.

a Obstetrics and Gynecology Department , Graduate Entry Medical School , University of Limerick , Limerick , Ireland.

Introduction: Individual placental and umbilical cord morphometry have been previously identified to have an association with fetal growth. This study aims to identify which of the morphometric measurements in combination are associated with pregnancies with small for gestational age (SGA) infants using digital imaging of the delivered placenta.

Material And Methods: This study examined 1005 placentas from consecutively delivered singleton pregnancies in a tertiary center. Read More

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http://dx.doi.org/10.1080/14767058.2019.1582628DOI Listing
February 2019

Longitudinal assessment of D-dimer and plasminogen activator inhibitor type-1 plasma levels in pregnant women with risk factors for preeclampsia.

Hypertens Pregnancy 2019 Feb 13;38(1):58-63. Epub 2019 Feb 13.

a Department of Clinical and Toxicological Analysis, Faculty of Pharmacy , Federal University of Minas Gerais , Belo Horizonte , Brazil.

Objective: Investigating D-Dimer/D-Di and plasminogen activator inhibitor type-1/PAI-1 levels throughout gestation in women with preeclampsia/PE risk factors.

Methods: D-Di and PAI-1 plasma levels were determined in 28 women at 12-19, 20-29, 30-34 and 35-40 weeks of gestation.

Results: D-Di was lower at 12-19 weeks and higher at 30-34 weeks in women who developed PE versus who did not develop it. Read More

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http://dx.doi.org/10.1080/10641955.2019.1577435DOI Listing
February 2019

Third trimester uterine artery Doppler indices as predictors of preeclampsia and neonatal small for gestational age.

J Matern Fetal Neonatal Med 2019 Feb 13:1-6. Epub 2019 Feb 13.

a Department of Obstetrics and Gynecology , University of South Florida Morsani College of Medicine , Tampa , FL , USA.

Objective: To test the hypothesis that third-trimester uterine artery Doppler (UAD) predicts adverse pregnancy and neonatal outcomes in a high-risk population.

Study Design: This is a nested case control study of women with singleton gestations referred for a fetal growth ultrasound between 24 and 36 weeks. Third-trimester UAD was performed if estimated fetal weight (Hadlock's chart) was <20th percentile as these patients were considered high risk for poor pregnancy outcomes. Read More

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http://dx.doi.org/10.1080/14767058.2019.1575804DOI Listing
February 2019

Placental Neuropeptide Y ( NPY) and NPY receptors expressions and serum NPY levels in preeclampsia.

Exp Biol Med (Maywood) 2019 Feb 13:1535370219831437. Epub 2019 Feb 13.

2 Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Impact Statement: Neuropeptide Y (NPY) has been reported as a vasoconstrictive substance which might be associated with preeclampsia. The novel findings of this study were that Y1R, Y2R, and Y5R expressions were significantly lower in the PE than the NP group. Moreover, the NPY receptor expression ratio between the PE/NP groups was lowest for Y2R (0. Read More

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http://dx.doi.org/10.1177/1535370219831437DOI Listing
February 2019

Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy.

Circulation 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, PA.

Background: Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of mid-pregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in mid-pregnancy identify not only a subset of women at risk for pregnancy complications, but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036632DOI Listing
February 2019

"Not taken seriously"-A qualitative interview study of postpartum Rwandan women who have experienced pregnancy-related complications.

PLoS One 2019 13;14(2):e0212001. Epub 2019 Feb 13.

Department of Clinical Sciences, Obstetrics and Gynaecology, Umeå University, Umeå, Sweden.

Background: There is limited knowledge on the women's experiences of pregnancy-related complications in Rwanda. This study aimed to investigate women's experiences and perceptions of specific complications during pregnancy and delivery and the consequences of these complications on postpartum health and family situation.

Methods: Data were collected through individual in-depth interviews (N = 15). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212001PLOS
February 2019

Predictive value of soluble fms-like tyrosine kinase-1 against placental growth factor for preeclampsia in a Chinese pregnant women population.

J Clin Lab Anal 2019 Feb 13:e22861. Epub 2019 Feb 13.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: The purpose of the present study was to explore the predictive effects of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) for preeclampsia.

Methods: A total of 1580 singleton pregnant women aged 18-45 years were included in this study. Serum samples were collected and stored frozen during their regular obstetric examinations. Read More

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http://doi.wiley.com/10.1002/jcla.22861
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http://dx.doi.org/10.1002/jcla.22861DOI Listing
February 2019
4 Reads

Human endogenous retroviruses HERV-H, HERV-W and HERV-K in preeclampsia.

Minerva Ginecol 2019 Feb 12. Epub 2019 Feb 12.

Department of Public Health and Pediatric Sciences, Citoimmunodiagnostics Laboratory, University of Turin, Medical School, Turin, Italy.

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http://dx.doi.org/10.23736/S0026-4784.19.04321-1DOI Listing
February 2019

Is there a future for cell-free fetal dna tests in screening for preeclampsia?

Ginekol Pol 2019 ;90(1):55-60

First Department of Obstetrics and Gynaecology, Medical University of Warsaw, Poland.

CffDNA screening is a powerful diagnostic tool in the prenatal diagnosis algorithm for chromosomal abnormalities. With detailed ultrasound examination as the mainstay of first-trimester risk assessment, cffDNA has been shown to be superior to first-trimester combined screening (FTCS) in false-positive rates for trisomy 21 detection. In light of the growing interest in cffDNA testing and the possibility of it replacing first-trimester biochemistry, we decided to investigate the usefulness of cffDNA tests in early-pregnancy risk assessment for preeclampsia (PE). Read More

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http://dx.doi.org/10.5603/GP.2019.0009DOI Listing
January 2019
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Decreased Filamin b expression regulates trophoblastic cells invasion through ERK/MMP-9 pathway in pre-eclampsia.

Ginekol Pol 2019 ;90(1):39-45

Department of Obstetrics, Affiliated Hospital of Qingdao University, China.

Objectives: The purpose of this study was to investigate the expression of Filamin b in the placental placenta of patients with early or late onset pre-eclampsia (PE) and its potential effects on the pathophysiology of the disease.

Methods And Methods: Immunohistochemistry staining, western blot assays and real time PCR were used to detect the expression level of FLN-b. The expression levels of MMP-2, MMP-9 and ERK1/2 proteins from control and FLN-b-silenced JEG-3 cells were also detected by western blot and JEG-3 cell invasion. Read More

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http://dx.doi.org/10.5603/GP.2019.0006DOI Listing
January 2019

Posterior Reversible Encephalopathy Syndrome and Azathioprine.

Eur J Case Rep Intern Med 2019 25;6(1):001032. Epub 2019 Jan 25.

Serviço Medicina III, Hospital Prof. Doutor Fernando Fonseca, Lisbon, Portugal.

Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. Read More

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http://dx.doi.org/10.12890/2019_001032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372047PMC
January 2019

Posterior reversible encephalopathy syndrome due to hypercalcaemia: a rare cause.

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity described by Hinchey in late 90's, characterised by variable associations of seizure activity, consciousness impairment ranging from confusion to coma, headaches, visual abnormalities, nausea/vomiting and focal neurological signs. Common causes are accelerated hypertension, eclampsia, preeclampsia, cytotoxic drug use and autoimmune diseases like systemic lupus erythematosus.We report a case of PRES in a 62-year-old female patient due to hypercalcemia secondary to vitamin D toxicity on treatment with calcium supplements and vitamin D for secondary hypoparathyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2017-223415DOI Listing
February 2019
1 Read

The health of children conceived by ART: 'the chicken or the egg?'

Hum Reprod Update 2019 Feb 12. Epub 2019 Feb 12.

Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark.

Worldwide, more than 7 million children have now been born after ART: these delivery rates are steadily rising and now comprise 2-6% of births in the European countries. To achieve higher pregnancy rates, the transfer of two or more embryos was previously the gold standard in ART. However, recently the practise has moved towards a single embryo transfer policy to avoid multiple births. Read More

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http://dx.doi.org/10.1093/humupd/dmz001DOI Listing
February 2019
2 Reads

Expectant or outpatient management of preeclampsia before 34 weeks: safe for mother but associated with increased stillbirth risk.

J Hum Hypertens 2019 Feb 11. Epub 2019 Feb 11.

The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China.

Today the only effective "treatment" for preeclampsia is to deliver at the optimal time for both maternal and foetal well-being. Studies reported that severe preeclampsia can benefit from the expectant management including mild preeclampsia between 34 and 37 weeks. However it is unclear whether mild preeclampsia before 34 weeks also benefits from the expectant management. Read More

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http://dx.doi.org/10.1038/s41371-019-0175-1DOI Listing
February 2019
2 Reads

Lvrn expression is not critical for mouse placentation.

J Reprod Dev 2019 Feb 10. Epub 2019 Feb 10.

Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

Preeclampsia is a systemic disease caused by abnormal placentation that affects both mother and fetus. It was reported that Laeverin (LVRN, also known as Aminopeptidase Q) was up-regulated in the placenta of preeclamptic patients. However, physiological and pathological functions of LVRN remained to be unknown. Read More

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https://www.jstage.jst.go.jp/article/jrd/advpub/0/advpub_201
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http://dx.doi.org/10.1262/jrd.2018-157DOI Listing
February 2019
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The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.02.002DOI Listing
February 2019
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Causes and contributory factors of maternal mortality: evidence from maternal and perinatal death surveillance and response in Ogun state, Southwest Nigeria.

BMC Pregnancy Childbirth 2019 Feb 11;19(1):63. Epub 2019 Feb 11.

Ogun State Primary Health Care Board, Abeokuta, Nigeria.

Background: Nigeria still ranks second globally in the number of maternal deaths. Most maternal death reviews in Nigeria are isolated research based reports from a single health facility. This study determined causes and contributory factors of maternal mortality in Ogun statefollowing a periodic State-widematernal and perinatal deaths surveillance and response (MPDSR) review. Read More

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http://dx.doi.org/10.1186/s12884-019-2202-1DOI Listing
February 2019
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T lymphocytes in the third trimester decidua in preeclampsia.

Hypertens Pregnancy 2019 Feb 11;38(1):52-57. Epub 2019 Feb 11.

c Department of Pathology, Faculty of Medicine , University of Nis , Nis , Serbia.

Objective: The aim of study was to conduct immunohistochemical quantification of CD3+ and CD8+ decidual lymphocytes in preeclampsia.

Methods: A study group included 30 cases of preeclampsia and a control group included 20 healthy pregnant women, all delivered by Cesarean section. Samples of placental bed were analyzed after immunohistochemical staining of CD45+, CD3+ and CD8+ cells. Read More

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http://dx.doi.org/10.1080/10641955.2019.1575393DOI Listing
February 2019
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Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

New Haven CT, Yale School of Medicine.

Background: Cardiovascular disease (CVD) is the leading cause of pregnancy-related death in the United States. (1) Identification of short-term indicators of cardiovascular morbidity has the potential to alter the course of this devastating disease among women. It has been established that hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease 10-30 years after delivery; however, little is known about the association of hypertensive disorders of pregnancy with cardiovascular (CV) morbidity during the delivery hospitalization. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.010DOI Listing
February 2019
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Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 Feb;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114435DOI Listing
February 2019
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Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.

Biochem Biophys Res Commun 2019 Feb 7. Epub 2019 Feb 7.

Division of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Sendai, 980-8578, Japan; Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. Electronic address:

Systemic lupus erythematosus (SLE) increases the risk of preterm birth and preeclampsia (PE). The flares of SLE during pregnancy or after delivery are also problematic. We have previously demonstrated that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress and improves PE-like phenotype and pregnancy outcomes in the mouse models of PE. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.110DOI Listing
February 2019
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The role of immunity in the pathogenesis and development of preeclampsia.

Authors:
Hui-Qing Lu Rong Hu

Scand J Immunol 2019 Feb 9:e12756. Epub 2019 Feb 9.

Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.

Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, however, the aetiology of preeclampsia still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents. Read More

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http://dx.doi.org/10.1111/sji.12756DOI Listing
February 2019

Prediction of Imminent Preeclampsia at 35-37 Weeks' Gestation.

Am J Obstet Gynecol 2019 Feb 7. Epub 2019 Feb 7.

Harris Birthright Research Centre for Fetal Medicine, King's College, London, UK. Electronic address:

Background: In the weeks preceding the clinical onset of preeclampsia (PE) the maternal serum level of the angiogenic placental growth factor (PLGF) is decreased and that of the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT) is increased. Women presenting at specialist clinics with signs or symptoms of hypertensive disorders have been stratified according to concentrations of PLGF or the ratio of concentrations of sFLT and PLGF to determine clinical management for the subsequent 1-4 weeks. An alternative approach for the prediction of PE is use of the competing risks model, a Bayes' theorem based method, to derive patient-specific risk for PE by various combinations of maternal characteristics and medical history with multiples of the median (MoM) values of biomarkers. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.235DOI Listing
February 2019
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High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia.

Redox Biol 2019 Jan 26;22:101126. Epub 2019 Jan 26.

Inserm U-1048, Université de Toulouse, France. Electronic address:

Decreased nitric oxide (NO) bioavailability plays a critical role in the pathophysiology of preeclampsia (PE). Recent evidence indicates that S-glutathionylation may occur on the endothelial nitric oxide synthase (eNOS), leading to eNOS uncoupling, characterized by a decreased NO production and an increased generation of superoxide anion (O). We hypothesized that eNOS glutathionylation may occur in PE placentas and participate in eNOS dysfunction. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101126DOI Listing
January 2019
2 Reads