40,478 results match your criteria Preeclampsia


Synthesis of Nomega-Nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice.

J Photochem Photobiol B 2019 Mar 22;194:183-187. Epub 2019 Mar 22.

Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital of Shandong Province, Shandong, China. Electronic address:

The purpose of this study is to synthesize Nomega-Nitro-L-arginine methyl ester (L-NAME) adsorbed reduced graphene oxide (RGO) sheets and demonstrate their protective impact on the detrimental effect detected in investigational pre-eclampsia, a prerequisite where increase in oxidative stress and decreased Nitric Oxide (NO) production were present. The synthesized graphene sheets were studies by using various characterization techniques. Later, a prerequisite similar to pre-eclampsia has been induced through chronic inhibition of NO fabrication using a 60 mg/kg/day L-NAME, orally in pregnant mice. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.013DOI Listing

Hypoxia-induced microRNA-141 regulates trophoblast apoptosis, invasion, and vascularization by blocking CXCL12β/CXCR2/4 signal transduction.

Biomed Pharmacother 2019 Apr 17;116:108836. Epub 2019 Apr 17.

Department of Obstetrics, Hainan General Hospital, Haikou, People's Republic of China.

Background: An impaired trophoblast invasion ability contributes to the development of pre-eclampsia (PE), and can be induced by the altered expression of various microRNAs (miRs). MiR-141 and CXCL12β (C-X-C motif chemokine ligand 12) signaling regulate trophoblast invasion and vascularization capabilities during PE pathogenesis; however, their interactions and underlying mechanisms of action remain unclear. We investigated how miR-141 modulates trophoblast invasion, with a focus on its interaction with CXCL12β signaling. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108836DOI Listing

CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34 + cell presence, and autophagy in the endometrium.

Biol Reprod 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA.

Placenta development is characterized by extensive angiogenesis and vascularization but if these processes are compromised placental dysfunction occurs, which is the underlying cause of pregnancy complications such as preeclampsia and intrauterine growth restriction. Dysregulation of placental angiogenesis has emerged as one of the main pathophysiological features in the development of placental insufficiency and its clinical consequences. The signaling axis initiated by chemokine ligand 12 (CXCL12) and its receptor CXCR4 stimulate angiogenesis in other tissues, and may be central to placental vascularization. Read More

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http://dx.doi.org/10.1093/biolre/ioz073DOI Listing

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

Placental programming of neuropsychiatric disease.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Division of Neonatology, Children's Research Institute at Children's National Medical Center, Washington, DC, USA.

The placenta is vital for fetal growth, and compromised function is associated with abnormal development, especially of the brain. Linking placental function to brain development is a new field we have dubbed neuroplacentology. Approximately 380,000 infants in the United States each year abruptly lose placental support upon premature birth, and more than 10% of pregnancies are affected by more insidious placental dysfunction such as preeclampsia or infection. Read More

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http://dx.doi.org/10.1038/s41390-019-0405-9DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study.

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

a Department of Obstetrics and Gynecology , KasrAlAini Hospital Cairo University , Cairo , Egypt.

This is a cohort study which included 100 cases with pre-eclampsia (PE) and 100 controls, done to compare the antepartum and postpartum uterine artery (UtA) Doppler velocimetry between them. UtA PI and RI were measured before and within 48-72 h after delivery. There was a highly significant difference between the cases and controls, regarding the UtA RI (0. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1563054DOI Listing
April 2019
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Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
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http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
1 Read

Memory T Cells in Pregnancy.

Front Immunol 2019 2;10:625. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Adaptations of the maternal immune response are necessary for pregnancy success. Insufficient immune adaption is associated with pregnancy pathologies such as infertility, recurrent miscarriage, fetal growth restriction, spontaneous preterm birth, and preeclampsia. The maternal immune system is continuously exposed to paternal-fetal antigens; through semen exposure from before pregnancy, through fetal cell exposure in pregnancy, and through microchimerism after pregnancy. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00625
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http://dx.doi.org/10.3389/fimmu.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455355PMC
April 2019
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Is Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPR-A) Expression in Human Placenta and Decidua Normal?

Med Sci Monit 2019 Apr 19;25:2868-2878. Epub 2019 Apr 19.

Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure and the salt-water balance in the blood. It acts through natriuretic peptide receptors (NPR), and the major biologically active ANP receptor is natriuretic peptide receptor-A (NPR-A). Aberrant forms of ANP and its receptors have been reported in patients with preeclampsia. Read More

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http://dx.doi.org/10.12659/MSM.915449DOI Listing

Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Human placenta development and a successful pregnancy is incumbent upon precise oxygen-dependent control of trophoblast migration/invasion. Persistent low oxygen leading to failed trophoblast invasion promotes inadequate spiral artery remodeling, a characteristic of preeclampsia. Angiomotin (AMOT) is a multifaceted scaffolding protein involved in cell polarity and migration, yet its upstream regulation and significance in the human placenta remain unknown. Read More

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https://insight.jci.org/articles/view/127009
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http://dx.doi.org/10.1172/jci.insight.127009DOI Listing
April 2019
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TRPM7, Magnesium, and Signaling.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Centre, University of Glasgow, Glasgow G12 8TA, UK.

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg, Ca, and Zn, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and is critically associated with intracellular signaling, including receptor tyrosine kinase (RTK)-mediated pathways. Emerging evidence indicates that growth factors, such as EGF and VEGF, signal through their RTKs, which regulate activity of TRPM6 and TRPM7. Read More

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https://www.mdpi.com/1422-0067/20/8/1877
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http://dx.doi.org/10.3390/ijms20081877DOI Listing
April 2019
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Preeclampsia-induced Liver Dysfunction, HELLP syndrome, and acute fatty liver of pregnancy.

Clin Liver Dis (Hoboken) 2014 Sep 26;4(3):69-73. Epub 2014 Sep 26.

Division of Gastroenterology and Hepatology University of Missouri Columbia MO.

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http://doi.wiley.com/10.1002/cld.409
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http://dx.doi.org/10.1002/cld.409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448736PMC
September 2014
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Comparing pregnancy outcomes and loss rates in elective twin pregnancy reduction to ongoing twin gestations in a large contemporary cohort.

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: As compared to singleton gestations, twin pregnancies are associated with a significantly higher risk of preterm birth, maternal complications, as well as fetal and neonatal morbidity and mortality. Multifetal pregnancy reduction (MPR) is a technique developed in the 1980s to reduce the fetal number in higher-order multiple pregnancies to reduce the risk of adverse pregnancy outcomes, most importantly preterm birth.

Objective: To compare pregnancy outcomes and loss rates in elective twin pregnancy reduction to ongoing twin gestations in a large contemporary cohort. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.001DOI Listing
April 2019
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Dyslipidemia and the role of the adipose tissue in early pregnancy in the BPH/5 mouse model for preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Clinical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, United States.

Background: The hypertensive pregnancy disorder preeclampsia (PE) is a leading cause of fetal/ maternal morbidity/mortality. Obesity increases the risk to develop PE, presumably via the release of inflammatory mediators from the adipose tissue, but the exact etiology remains largely unknown.

Methods: Using obese PE-like BPH/5 and lean gestational age-matched C57Bl6 mice, we aimed to obtain insight into differential reproductive white adipose tissue (rWAT) gene expression, circulating lipids and inflammation at the maternal-fetal interface during early pregnancy. Read More

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http://dx.doi.org/10.1152/ajpregu.00334.2018DOI Listing
April 2019
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Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.

Ann N Y Acad Sci 2019 Apr 17. Epub 2019 Apr 17.

Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.

Maternal anemia is a well-recognized global health problem; however, there remain questions on specific hemoglobin (Hb) thresholds that predict health risk or protection for mother and child. We conducted a systematic review and meta-analysis to examine the associations of maternal Hb concentrations with a range of maternal and infant health outcomes, accounting for the timing of measurement (preconception, and first, second, and third trimesters), etiology of anemia, and cutoff category. The systematic review included 272 studies and the meta-analysis included 95 studies. Read More

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http://dx.doi.org/10.1111/nyas.14093DOI Listing
April 2019
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Pakistan Developmental Origins of Health and Disease (DOHaD) Society: addressing the 'DO' component of DOHaD.

J Dev Orig Health Dis 2019 Apr;10(2):141-143

1Department of Obstetrics and Gynaecology, Maternal Fetal Medicine Unit,The Aga Khan University,Karachi,Pakistan.

Adverse intrauterine environment could serve as an important stimulus for postnatal altered health status and for increased susceptibility to long-term non-communicable diseases (NCDs). The notion is now recognized as the Developmental Origins of Health and Disease (DOHaD), which was first proposed by Sir David Barker. Since then, several scientific disciplines have strived to measure the magnitude of the early fetal programming and later risk of diseases. Read More

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http://dx.doi.org/10.1017/S2040174418000636DOI Listing
April 2019
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The relationship between maternal body mass index and pregnancy outcomes in twin compared with singleton pregnancies.

Int J Obes (Lond) 2019 Apr 16. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

Objecive: Women with twins have an a priori increased risk for many of the complications associated with maternal obesity. Thus, the impact of maternal obesity in twins may differ from that reported in singletons. In addition, given the increased metabolic demands in twin pregnancies, the impact of maternal underweight may be greater in twin compared with singleton gestations. Read More

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http://dx.doi.org/10.1038/s41366-019-0362-8DOI Listing
April 2019
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Screening for Elevated Blood Lead Levels in Children and Pregnant Women: US Preventive Services Task Force Recommendation Statement.

JAMA 2019 04;321(15):1502-1509

Tufts University, Medford, Massachusetts.

Importance: Elevated blood lead levels in children are associated with neurologic effects such as behavioral and learning problems, lower IQ, hyperactivity, hearing problems, and impaired growth. In pregnant women, lead exposure can impair organ systems such as the hematopoietic, hepatic, renal, and nervous systems, and increase the risk of preeclampsia and adverse perinatal outcomes. Many of the adverse health effects of lead exposure are irreversible. Read More

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http://dx.doi.org/10.1001/jama.2019.3326DOI Listing

Investigation of optimal pathways for preeclampsia using network-based guilt by association algorithm.

Exp Ther Med 2019 May 18;17(5):4139-4143. Epub 2019 Mar 18.

Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, P.R. China.

This study investigated optimal pathways for preeclampsia (PE) utilizing the network-based guilt by association (GBA) algorithm. The inference method consisted of four steps: preparing differentially expressed genes (DEGs) between PE patients and normal controls from gene expression data; constructing co-expression network (CEN) for DEGs utilizing Spearman's correlation coefficient (SCC) method; and predicting optimal pathways by network-based GBA algorithm of which the area under the receiver operating characteristics curve (AUROC) was gained for each pathway. There were 351 DEGs and 61,425 edges in the CEN for PE. Read More

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http://dx.doi.org/10.3892/etm.2019.7410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447911PMC
May 2019
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Placental protein 13 (PP13) stimulates rat uterine vessels after slow subcutaneous administration.

Int J Womens Health 2019 27;11:213-222. Epub 2019 Mar 27.

Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland,

Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications of pregnancy. Previous studies by our group have shown that PP13 lowers blood pressure in pregnant rats, increases the size and weight of pups and placentas, and induces vasodilation of resistance arteries through endothelial signaling pathways involving endothelial nitric oxid synthase and prostaglandin.

Methods: In the present study, the effect of PP13 was investigated in nonpregnant female Sprague Dawley rats (n=27). Read More

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https://www.dovepress.com/placental-protein-13-pp13-stimulat
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http://dx.doi.org/10.2147/IJWH.S188303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443218PMC
March 2019
2 Reads

Perspectives and pregnancy outcomes of maternal Ramadan fasting in the second trimester of pregnancy.

BMC Pregnancy Childbirth 2019 Apr 15;19(1):128. Epub 2019 Apr 15.

Department of Basic Science, College of Basic Science, Hawler Medical University, Erbil, Iraq.

Background: There are controversies over the effects of Ramadan fasting on pregnancy outcomes, and women's perspectives of fasting are diverse. This study aimed to assess the perspectives and pregnancy outcomes of maternal Ramadan fasting in the second trimester of pregnancy.

Methods: A case-control study was conducted at Hawler Maternity Teaching Hospital of Erbil, Iraq from October 2017 to January 2018. Read More

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http://dx.doi.org/10.1186/s12884-019-2275-xDOI Listing
April 2019
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Practical approach to the prevention of preeclampsia: from screening to pharmaceutical intervention.

J Matern Fetal Neonatal Med 2019 Apr 15:1-7. Epub 2019 Apr 15.

a Weill Cornell Medicine in Qatar , Doha , Qatar.

Preeclampsia occurs in 3-8% of the pregnancies and is associated with a high rate of morbi-mortality, both for mothers and the fetus. Screening and prevention of patients at risk are the optimal way to reduce the morbi-mortality of this disease. To set-up a preventive approach to preeclampsia (PE), one has to identify using a screening strategy for the population at risk and propose them an appropriate therapeutic intervention that would bear a favorable benefits/risk ratio. Read More

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http://dx.doi.org/10.1080/14767058.2019.1588877DOI Listing
April 2019
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IL-36 Cytokines: Regulators of Inflammatory Responses and Their Emerging Role in Immunology of Reproduction.

Int J Mol Sci 2019 Apr 3;20(7). Epub 2019 Apr 3.

Placenta Lab, Department of Obstetrics, Jena University Hospital, 07740 Jena, Germany.

The IL-36 subfamily of cytokines has been recently described as part of the IL-1 superfamily. It comprises three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ), their receptor (IL-36R), and one antagonist (IL-36Ra). Although expressed in a variety of cells, the biological relevance of IL-36 cytokines is most evident in the communication between epithelial cells, dendritic cells, and neutrophils, which constitute the common triad responsible for the initiation, maintenance, and expansion of inflammation. Read More

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http://dx.doi.org/10.3390/ijms20071649DOI Listing
April 2019
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Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India.

Gene 2019 Apr 12;704:68-73. Epub 2019 Apr 12.

Department of Anthropology, University of Delhi, Delhi, India. Electronic address:

Aim: The purpose of the present study is to evaluate and understand the association of global and MTHFR gene specific methylation in preeclampsia and recurrent miscarriages in light of MTHFR C677T polymorphism.

Methods: The subjects comprised of recurrent miscarriage cases, their gestation matched controls, preeclampsia cases and matched controls. A set of women at full term were also recruited. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.036DOI Listing
April 2019
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Therapeutic Implications of Inherited Thrombophilia in Pregnancy.

Am J Ther 2019 Apr 12. Epub 2019 Apr 12.

University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Background: Inherited (hereditary) thrombophilia is a genetic disorder that affects coagulation, being responsible for more than 60% of idiopathic (spontaneous or unprovoked) thromboembolic events. Association of inherited thrombophilia with pregnancy increases the risk of thromboembolic disease, and it may be related to many complications, such as preeclampsia, recurrent miscarriage intrauterine growth restriction, early detachment of placenta, and prematurity.

Areas Of Uncertainty: Interpretation of a positive test for thrombophilia in pregnant women is difficult because they have many natural changes in the coagulation system. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000985DOI Listing
April 2019
1 Read

Vitamin D status in pregnant women visiting a tertiary care center of North Eastern India.

J Family Med Prim Care 2019 Feb;8(2):356-360

Department of Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Studies of vitamin D (VD) physiology suggest that effects of vitamin D deficiency (VDD) could be much broader than rickets including cardiovascular disease, cancers, diabetes, infection, and allergy and pregnancy complications. Data regarding the prevalence of hypovitaminosis in pregnancy are scanty especially in north eastern part of India. Therefore, this study has undertaken with the intention to find out prevalence and outcome of hypovitaminosis of VD in pregnancy. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_404_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436274PMC
February 2019
1 Read

Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges.

Front Immunol 2019 21;10:478. Epub 2019 Mar 21.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Inflammation is a central feature and is implicated as a causal factor in preeclampsia and other hypertensive disorders of pregnancy. Inflammatory mediators and leukocytes, which are elevated in peripheral blood and gestational tissues, contribute to the uterine vascular anomalies and compromised placental function that characterize particularly the severe, early onset form of disease. Regulatory T (Treg) cells are central mediators of pregnancy tolerance and direct other immune cells to counteract inflammation and promote robust placentation. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00478
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http://dx.doi.org/10.3389/fimmu.2019.00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448013PMC
March 2019
2 Reads

Platelet function in preeclampsia - a systematic review and meta-analysis.

Platelets 2019 Apr 14:1-14. Epub 2019 Apr 14.

a Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.

Preeclampsia is a serious pregnancy-related complication. Platelets are potentially important in the pathogenesis of preeclampsia, and platelet function analyses may prove as sensitive preeclampsia biomarkers. This study aimed to systematically review and summarise the literature on platelet function markers in preeclampsia. Read More

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http://dx.doi.org/10.1080/09537104.2019.1595561DOI Listing
April 2019
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The efficacy of enoxaparin for recurrent abortion: a meta-analysis of randomized controlled studies.

J Matern Fetal Neonatal Med 2019 Apr 14:1-151. Epub 2019 Apr 14.

b Chongqing Hechuan Hospital , Chongqing , China.

Introduction: The efficacy of enoxaparin for recurrent abortion remains controversial. We conduct a systematic review and meta-analysis to explore the influence of enoxaparin versus placebo on recurrent abortion.

Methods: We search PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases through February 2019 for randomized controlled trials (RCTs) assessing the effect of enoxaparin versus placebo on recurrent abortion. Read More

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http://dx.doi.org/10.1080/14767058.2019.1608433DOI Listing

Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia.

J Matern Fetal Neonatal Med 2019 Apr 14:1-161. Epub 2019 Apr 14.

a Department of Obstetrics and Gynecology , Aichi Medical University School of Medicine , Aichi , Japan.

Objective: This study aimed to investigate the etiology and pathology of preeclampsia (PE), a two-stage disorder involving uteroplacental dysfunction resulting from abnormal implantation and placentation, and gestational hypertension (GH), for which maternal organic vascular disorder is often an underlying factor.

Methods: We assessed concentrations of oxygen free radicals (d-ROMs), maternal angiogenic factor (PlGF), and antiangiogenic factor (sFlt-1), placental hypoxic changes, oxidative DNA damage, and maternal organic vascular disorders in 23 women with PE (PE group), 13 with GH (GH group), and 16 with uncomplicated pregnancies (normal group). Intima-media thickness (IMT) of the carotid artery was assessed as a proxy for maternal organ vascular disorder. Read More

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http://dx.doi.org/10.1080/14767058.2019.1608175DOI Listing

Optical Coherence Tomography Findings in Pre-Eclampsia: A Preliminary Receiver Operating Characteristic Analysis on Choroidal Thickness for Disease Severity.

Curr Eye Res 2019 Apr 15:1-5. Epub 2019 Apr 15.

a Department of Ophthalmology , Bakirkoy Dr. Sadi Konuk Training and Research Hospital , Istanbul , Turkey.

Purpose: To evaluate qualitative optical coherence tomography (OCT) findings and quantitative parameters, such as central macular thickness (CMT) and subfoveolar choroidal thickness (SFCT), in the eyes of preeclamptic women.

Methods: The prospective, comparative, cross-sectional study included 52 eyes of 52 preeclamptic (PE) women and 54 eyes of 54 healthy pregnant women in their second or third trimester. Central macular thickness (CMT), subfoveolar choroidal thickness (SFCT), were evaluated in relation to presence of positive qualitative OCT findings such as any subretinal or intraretinal fluid, irregularity on the external photoreceptor and RPE layer, or presence of pigment epithelial detachment. Read More

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http://dx.doi.org/10.1080/02713683.2019.1600198DOI Listing
April 2019
2 Reads

Metabolomics Revealed Decreased Level of Omega-3 PUFA-derived Protective Eicosanoids in Pregnant Women with Pre-eclampsia.

Clin Exp Pharmacol Physiol 2019 Apr 15. Epub 2019 Apr 15.

Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University, Tianjin, China.

Pre-eclampsia (PE) is considered a leading cause of mortality and morbidity in pregnant women worldwide. Eicosanoids derived from polyunsaturated fatty acids (PUFAs) and their metabolites might play an important role in the occurrence and development of PE. Omega-3 PUFAs are nutrients that are popular supplements for pregnant women and can reduce blood pressure. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
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http://dx.doi.org/10.1111/1440-1681.13095DOI Listing
April 2019
2 Reads

Dietary patterns before and during pregnancy and maternal outcomes: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):705S-728S

Food and Nutrition Service, USDA, Alexandria, VA.

Background: Hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) are common maternal complications during pregnancy, with short- and long-term sequelae for both mothers and children.

Objective: Two systematic review questions were used to examine the relation between 1) dietary patterns before and during pregnancy, 2) HDP, and 3) GDM.

Methods: A search was conducted from January 1980 to January 2017 in 9 databases including PubMed, Embase, and Cochrane. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ajcn/nqy216DOI Listing
March 2019
3 Reads
6.770 Impact Factor

Challenges in Managing Pregnancy in Underserved Women with Chronic Kidney Disease.

Am J Nephrol 2019 Apr 12;49(5):386-396. Epub 2019 Apr 12.

Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, University of Guadalajara Health Sciences Center, Guadalajara, Mexico,

Background: Chronic kidney disease (CKD) is a global public health problem and is linked to adverse outcomes during pregnancy; the high prevalence of CKD (3-6%) in women of childbearing age is of particular relevance in emerging countries where CKD prevalence is higher and resources are limited. Although CKD is a public health problem in Mexico, there is scant information on outcomes in pregnant CKD women in this country. We report maternal-fetal outcomes in a prospective cohort of poor, CKD pregnant women, and compare results with those of pregnant women without CKD. Read More

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https://www.karger.com/Article/FullText/499964
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http://dx.doi.org/10.1159/000499964DOI Listing
April 2019
2 Reads

Maternal Risk Factors and Perinatal Characteristics in Congenital Diaphragmatic Hernia: A Nationwide Population-Based Study.

Fetal Diagn Ther 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.

Background: The etiology of congenital diaphragmatic hernia (CDH) remains poorly understood. We hypothesize that environmental factors play an important role in the development of CDH.

Aim: The objective of this study was to investigate associated maternal risk factors in pregnancies with CDH. Read More

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http://dx.doi.org/10.1159/000497619DOI Listing
April 2019
2 Reads

Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity.

Mol Cell Endocrinol 2019 Apr 11. Epub 2019 Apr 11.

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.

In the human placenta, extravillous trophoblasts (EVTs) invade maternal decidual tissues (interstitial trophoblasts) and maternal spiral arteries (endovascular trophoblasts). Although endovascular trophoblasts are directly exposed to maternal blood containing complement components, they are not eliminated by complement-dependent cytotoxicity (CDC). In this study, we investigated the expression and possible function of CD59, one of the membrane-bound complement regulators, in EVTs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193010
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http://dx.doi.org/10.1016/j.mce.2019.04.006DOI Listing
April 2019
2 Reads

Translating Maternal Mortality Review Into Quality Improvement Opportunities in Response to Pregnancy-Related Deaths in California.

J Obstet Gynecol Neonatal Nurs 2019 Apr 11. Epub 2019 Apr 11.

Objective: To describe quality improvement opportunities (QIOs) associated with the five leading causes of pregnancy-related death in California and the methods by which the QIOs were collected by the California Pregnancy-Associated Mortality Review committee.

Design: Qualitative, descriptive design using thematic analysis.

Sample: A total of 907 QIOs identified from 203 cases of pregnancy-related deaths from cardiovascular disease, preeclampsia/eclampsia, hemorrhage, venous thromboembolism, and sepsis that occurred in California from 2002 to 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.03.003DOI Listing
April 2019
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Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Preeclampsia/Eclampsia.

J Obstet Gynecol Neonatal Nurs 2019 Apr 10. Epub 2019 Apr 10.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from preeclampsia/eclampsia by the California Pregnancy-Associated Mortality Review Committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 242 QIOs identified from 54 cases of pregnancy-related deaths from preeclampsia/eclampsia in California between 2002 and 2007. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.02.008DOI Listing
April 2019
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Opportunities for hospitals, hospital systems and leadership to improve VTE prophylaxis.

Semin Perinatol 2019 Mar 9. Epub 2019 Mar 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6651 Main Street, Suite F420, Houston, Texas.

A sustained increase in the maternal death rate in the U.S. remains one of the most challenging issues of the twenty-first century. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193003
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http://dx.doi.org/10.1053/j.semperi.2019.03.007DOI Listing
March 2019
2 Reads

Liver Transplantation for Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome: A Propensity-score Matched Long-term Survival of the Scientific Registry of Transplant Recipients Dataset.

Transplant Proc 2019 Apr 9;51(3):805-812. Epub 2019 Jan 9.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address:

Background: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a life-threatening form of pre-eclampsia/eclampsia, with liver transplantation being the life-saving option for treatment for those who develop severe hepatic complications.

Methods: We retrospectively analyzed data from the Scientific Registry of Transplant Recipients (SRTR) through October 1, 1987, to December 31, 2014. Forty patients were listed for liver transplantation, with 18 patients finally receiving their transplant. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.032DOI Listing
April 2019
1 Read

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.

PLoS One 2019 12;14(4):e0215326. Epub 2019 Apr 12.

Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215326PLOS
April 2019
2 Reads

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia.

Clin Exp Hypertens 2019 Apr 12:1-4. Epub 2019 Apr 12.

i Prenatal Diagnosis Center , Maternity and Child Care of Jinan , Jinan , China.

Objectives: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women.

Methods: We researched the genetic distribution of rs2071746 polymorphism in HMOX1 by the TaqMan allelic discrimination real-time PCR between 1235 PE patients and 1720 healthy women. Read More

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http://dx.doi.org/10.1080/10641963.2019.1601202DOI Listing
April 2019
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Hypertensive disorders of pregnancy increase the risk of developing neovascular age-related macular degeneration in later life.

Hypertens Pregnancy 2019 Apr 12:1-8. Epub 2019 Apr 12.

c Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, Steele Center for Translational Medicine , University of Utah , Salt Lake City , USA.

Background: Hypertensive disorders of pregnancy (HDP) and short-term adverse outcomes have long been recognized; however, survivors remain at risk of long-term complications. We investigated whether HDP is associated with the development of choroidal neovascular age-related macular degeneration (CNV AMD).

Methods: We identified 31,454 women who experienced HDP based on Utah birth certificates and 62,908 unexposed women matched 2:1 to the exposed. Read More

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http://dx.doi.org/10.1080/10641955.2019.1597107DOI Listing
April 2019
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Obstetrical and infant outcomes among women with neoplasms during pregnancy.

Cancer Causes Control 2019 Apr 11. Epub 2019 Apr 11.

Department of Epidemiology, University of Washington (UW), Seattle, WA, USA.

Purpose: One in 1,000 pregnancies is complicated by malignancies. Prevalence is greater for benign neoplasms. Adverse outcomes among women with malignancies have been reported. Read More

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http://link.springer.com/10.1007/s10552-019-01167-1
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http://dx.doi.org/10.1007/s10552-019-01167-1DOI Listing
April 2019
5 Reads

Spinal-Induced Hypotension in Preeclamptic and Healthy Parturients Undergoing Cesarean Section.

Open Access Maced J Med Sci 2019 Mar 30;7(6):996-1000. Epub 2019 Mar 30.

Institute of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: There is a widespread belief that spinal anaesthesia in patients with preeclampsia might cause severe hypotension and decreased uteroplacental perfusion. This study aimed to evaluate the incidence and severity of spinal induced-hypotension in preeclamptics and healthy parturients.

Methods: Total of 78 patients (40 healthy and 38 preeclamptic) undergoing a C-Section with spinal anaesthesia were included. Read More

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http://dx.doi.org/10.3889/oamjms.2019.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454163PMC
March 2019
1 Read

Activation of a TLR9 mediated innate immune response in preeclampsia.

Sci Rep 2019 Apr 11;9(1):5920. Epub 2019 Apr 11.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland.

Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysiology of this disease. Mitochondrial DAMPs such as mtDNA bind specific pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrophils, subsequently activating them and triggering an innate response. Read More

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http://dx.doi.org/10.1038/s41598-019-42551-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459858PMC
April 2019
1 Read

Evaluation of Some Cytokines and Gene Expressions in Pre-eclampsia.

Pak J Biol Sci 2019 Jan;22(3):148-153

Background And Objective: Preeclampsia(PE) is adisordercharacterized byhypertensionandproteinuria. There is accumulating evidence that this is a disease of the endothelium. Angiogenic factors may be responsible for the regulation of placental vascular development. Read More

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http://www.scialert.net/abstract/?doi=pjbs.2019.148.153
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http://dx.doi.org/10.3923/pjbs.2019.148.153DOI Listing
January 2019
2 Reads

New Paradigm in the Role of Regulatory T Cells During Pregnancy.

Front Immunol 2019 26;10:573. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.

Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4CD25FoxP3 regulatory T (Treg) cells is established during pregnancy. Paternal antigen-specific Treg cells accumulate during pregnancy, and seminal plasma priming plays an important role in expanding paternal antigen-specific Treg cells in mouse models. Although paternal-antigen specific Treg cells have not been identified in humans, recent studies suggest that antigen-specific Treg cells exist and expand at the feto-maternal interface in humans. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00573
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http://dx.doi.org/10.3389/fimmu.2019.00573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443934PMC
March 2019
3 Reads