39,633 results match your criteria Preeclampsia


Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

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December 2018
2 Reads

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway.

Cell Physiol Biochem 2018 Dec 6;51(5):2030-2040. Epub 2018 Dec 6.

Department of Obstetrics, The First Affiliated Hospital, Chongqing Medical University, Chongqing,

Background/aims: Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

Methods: LN-α5 expression levels were examined by reverse-transcriptase polymerase chain reaction (RT-PCR), and further confirmed by western blotting and immunofluorescence staining. Read More

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December 2018
2 Reads

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
6 Reads

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018
1 Read

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018

Brachial and uterine arteries Doppler in healthy women and with preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):360-363. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", División de Investigación en Salud. Ciudad de México, México

Objective: To compare the Doppler ultrasound parameters of the uterine and brachial arteries, between healthy pregnant women and pregnant women with preeclampsia.

Methods: 102 pregnant women were studied in the third trimester, group I 83 healthy women and group II 19 patients with severe preeclampsia. All of them underwent Doppler ultrasound of the uterine arteries, measuring the pulsatility index (PI) and determining the presence of proto-diastolic notch. Read More

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November 2018

Taming preeclampsia at its source.

Nat Biotechnol 2018 Dec;36(12):1151-1152

Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.

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December 2018

Assessing the effect of dexmedetomidine in patients with pre-eclampsia.

Eur J Anaesthesiol 2019 Jan;36(1):75

From the Department of Anaesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (BH, XZ, JS), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

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January 2019

Profound bilateral post-partum retinal circulation ischemia in two diabetic mothers with pre-eclampsia.

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

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Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

Chymase is a major angiotensin-converting enzyme (ACE)-independent angiotensin convertase, and its expression is upregulated in the maternal vascular endothelium in preeclampsia, a hypertensive disorder in human pregnancy. Increased chymase-dependent angiotensin II generation has been reported in several cardiovascular diseases, including atherosclerosis and aneurysmal lesions. However, it remains unclear how chymase is activated. Read More

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December 2018

Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia.

J Perinatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Epidemiology, University of Iowa, Iowa City, IA, USA.

Objective: Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.

Study Design: A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Read More

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December 2018

Acute Pulmonary Edema in a Pregnant Patient with Undiagnosed Levo-Transposition of the Great Arteries.

Am J Case Rep 2018 Dec 6;19:1445-1448. Epub 2018 Dec 6.

Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.

BACKGROUND Levo-transposition of the great arteries (L-TGA) is a rare form of congenital heart disease that may go unrecognized until adulthood. Parturient women with L-TGA have a high likelihood of developing acute pulmonary edema and cardiac dysrhythmias during the peri-partum period. CASE REPORT We present the case of a 32-year-old primigravida patient with previously unknown diagnosis of L-TGA, presenting with preeclampsia, whose peri-partum course was complicated by the development of acute pulmonary edema, complete heart block, and acute hypoxic respiratory failure. Read More

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December 2018

Application of iTRAQ proteomics in identification of the differentially expressed proteins of placenta of pregnancy with preeclampsia.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Wuxi Matemal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.

Objective: To explore the differential protein profile of preeclampsia and identify its potential biomarker.

Methods: Around 20 pregnant women with preeclampsia (preeclampsia group) and 20 normal-term pregnancy (normal group) were collected from 2017 to 2018 in the study. Total protein of placenta tissues was extracted, denaturized, deoxidized, and enzymolyzed. Read More

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December 2018

Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12.

Acta Paediatr 2018 Dec 1. Epub 2018 Dec 1.

Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.

Aim: We examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12-year-old offspring.

Methods: This secondary analyses of a prospective mother-child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, The Netherlands. Read More

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December 2018

Placental thickness on ultrasound and neonatal birthweight.

J Perinat Med 2018 Dec 3. Epub 2018 Dec 3.

Penn State Hershey Medical Center, Division of Maternal Fetal Medicine, Hershey, PA, USA.

Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. Read More

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December 2018

High Sensitivity Cardiac Troponin I Levels in Normal Pregnancy And When Complicated By Hypertension.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: To examine the association of circulating concentrations of high-sensitivity cardiac troponin I (hs-Tn) in the various trimesters of pregnancy in patients with and without hypertension.

Method: Prospective cross-sectional study of pregnant and post-natal women aged between 18-35 years of age with no coexisting disease. Serum samples were analysed for hs-TnI. Read More

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November 2018
3 Reads

Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive AT1-B2 Receptor Heteromers.

Cell 2018 Nov 20. Epub 2018 Nov 20.

Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Preeclampsia is the most frequent pregnancy-related complication worldwide with no cure. While a number of molecular features have emerged, the underlying causal mechanisms behind the disorder remain obscure. Here, we find that increased complex formation between angiotensin II AT1 and bradykinin B2, two G protein-coupled receptors with opposing effects on blood vessel constriction, triggers symptoms of preeclampsia in pregnant mice. Read More

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November 2018

Early screening for gestational diabetes mellitus is not associated with improved pregnancy outcomes: an observational study including 9795 women.

Diabetes Metab 2018 Nov 28. Epub 2018 Nov 28.

Paris 13 university, Sorbonne Paris Cité, AP-HP, Jean-Verdier hospital, department of obstetrics and gynecology, Bondy, France.

Aims: In addition to screening for hyperglycaemia during pregnancy after 24 weeks of gestation (WG), the current guidelines also suggest screening in early pregnancy and referring women with early gestational diabetes mellitus (eGDM) or overt diabetes (OD) for immediate care. Our aim was to evaluate this strategy.

Methods: This study evaluated, at our hospital (2012-2016), whether the incidence of a predefined composite outcome (preeclampsia, large-for-gestational-age infant, shoulder dystocia) and secondary outcomes was different when women were screened only after 22WG ('late screening only') or before 22WG and treated for eGDM or OD if present, with repeat screening after 22WG if absent ('early ± late screening'). Read More

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November 2018

Placental inflammation by HMGB1 activation of TLR4 at the syncytium.

Placenta 2018 Dec 2;72-73:53-61. Epub 2018 Nov 2.

Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. Electronic address:

Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal circulation. Activation of toll-like receptors (TLR)2 and TLR4 by endogenous danger signals plays a role in inflammatory diseases. Read More

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December 2018

Effects of consuming sugars and alternative sweeteners during pregnancy on maternal and child health: evidence for a secondhand sugar effect.

Proc Nutr Soc 2018 Dec 3:1-10. Epub 2018 Dec 3.

Department of Preventive Medicine,University of Southern California Health Sciences Campus,2250 Alcazar Street, Los Angeles, CA 90033,USA.

Consumption of sugar and alternative low- or no-energy sweeteners has increased in recent decades. However, it is still uncertain how consumption of sugar and alternative sweeteners during pregnancy affects pregnancy outcomes and long-term offspring health. This review aims to collate the available evidence surrounding the consequences of sugar and alternative sweetener consumption during pregnancy, a so-called secondhand sugar effect. Read More

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December 2018

Serum endocan concentration and its correlation with severity of hypertensive disorders in pregnancy.

J Matern Fetal Neonatal Med 2018 Dec 2:1-7. Epub 2018 Dec 2.

a Department of Perinatology and Gynecology , Poznan University of Medical Sciences , Poznań , Poland.

Introduction: Endocan plays a role in the development of vascular tissue in health and disease and is an indicator of endothelial cells activation and angiogenesis.

Objective: The aim of this study was to investigate the relationship between endocan serum levels and various types of hypertensive disorders in pregnant women.

Patients And Methods: We created three study groups (preeclampsia [n = 60], chronic hypertension [n = 39], gestational hypertension [n = 58]) and the control group consisting of 59 healthy pregnant women. Read More

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December 2018

Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy.

Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy.

Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Read More

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December 2018
0.489 Impact Factor

Components of the antepartum, intrapartum, and postpartum exposome impact on distinct short-term adverse neonatal outcomes of premature infants: A prospective cohort study.

PLoS One 2018 5;13(12):e0207298. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United states of America.

We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131). Newborns (n = 372) were followed until death or discharge. Read More

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December 2018
1 Read

Effect of Ethanol Extract on the Nitric Oxide Content and Renal Arteriole Diameter of a Pre-eclampsia Mouse Model.

Eurasian J Med 2018 Oct;50(3):148-151

Laboratory of Parasitology, Brawijaya University School of Medicine, Malang, East Java, Indonesia.

Objective: The aim of this study was to investigate the effect of Nigella sativa ethanol extract on nitric oxide (NO) levels and renal arteriole diameter of a pre-eclampsia mouse model.

Materials And Methods: This experimental study was conducted using a post-test only control group design. Thirty BALB/c mice were divided into six groups: one negative control (normal pregnant mice), one positive control (pre-eclampsia model), and four groups of pre-eclampsia mice treated with varying doses of N. Read More

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October 2018

A novel RNA interference approach to targeting sFLT1 in pre-eclampsia.

Authors:
Ellen F Carney

Nat Rev Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Nature Reviews Nephrology, .

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December 2018
1 Read

Mortalité maternelle en France et dans le monde.

Rev Prat 2016 Sep;66(7):721-726

Service d'anesthésie, Hôpital femme-mère-enfant, CHU de Lyon, Bron, France.

International and French maternal mortality. Maternal mortality, defined as the death of a woman during pregnancy and 42 days following delivery, remains a major challenge to health systems worldwide and a known indicator of development. As did the Millennium Development Goal 5, France health ministry targeted a reduction in maternal mortality ratio. Read More

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September 2016

Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women.

PLoS Med 2018 Dec 4;15(12):e1002710. Epub 2018 Dec 4.

Robinson Research Institute, University of Adelaide, Adelaide, Australia.

Background: Obesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been investigated. Read More

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December 2018
1 Read

Maternal/Perinatal Outcome in Women with Sickle Cell Disease: A Comparison of Two Time Periods.

South Med J 2018 Dec;111(12):742-745

From the Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, the Department of Obstetrics and Gynecology of the University of Mississippi Medical Center, Jackson, and Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City.

Objective: To compare pregnancy outcomes in women with sickle cell disease from recent deliveries with a similar group delivered earlier.

Methods: During a 12-year period (2005-2016), data from pregnant women with hemoglobin SS or SC were collected from three university medical centers and compared with earlier studies (1979-2003) involving similar patients. The primary endpoints were maternal complications during pregnancy and newborn outcomes. Read More

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December 2018

Optic nerve ultrasound for fluid status assessment in patients with severe preeclampsia.

Radiol Oncol 2018 Nov 26;52(4):377-382. Epub 2018 Nov 26.

Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Center Ljubljana, Ljubljana, Slovenia.

Background There are no data on usefulness of optic nerve sheath diameter (ONSD) as a marker of patient's fluid status in preeclampsia. The objective was to examine potential correlation between ONSD and lung ultrasound estimates of extravascular lung water in severe preeclampsia. Patients and methods Thirty patients with severe preeclampsia were included. Read More

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November 2018
1 Read

The effect of thyroid functions on osteopenia of prematurity in preterm infants.

J Pediatr Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

Division of Neonatology, Zekai Tahir Burak Women's Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Altıntag, Ankara, Turkey.

Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Read More

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December 2018
1 Read

Spontaneous liver rupture secondary to distal right hepatic artery microaneurysms in a patient admitted due to Staphylococcus aureus pneumonia.

Rev Esp Enferm Dig 2018 Dec 4;111. Epub 2018 Dec 4.

Cirugía General y del Aparato Digestivo, Hospital Universitario Ramón y Cajal.

Spontaneous liver rupture is an uncommon and life-threatening condition often associated with high mortality rate. The most common causes are preeclampsia and HELLP syndrome during pregnancy, liver tumours and overdosing of anticoagulant therapy, however, hepatic rupture in the absence of underlying pathology is an extremely rare occurrence. Treatment can include observation, embolization, hepatic artery ligation, hepatic lobectomy, hematoma evacuation and packing, and even liver transplantation has been described. Read More

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December 2018

Characteristics and Outcome of Obstetric Acute Kidney Injury in Pakistan: A Single-center Prospective Observational Study.

Cureus 2018 Sep 26;10(9):e3362. Epub 2018 Sep 26.

Nephrology, Allama Iqbal Medical College, Lahore, PAK.

Introduction Acute kidney injury (AKI) continues to be a cause of increased morbidity and mortality in pregnant women. While studies have been conducted on the incidence and etiology of this complication, the outcomes of obstetric AKI have not been extensively investigated. The primary focus of this prospective observational study was to analyze the risk factors, etiologies as well as maternal and fetal outcomes of AKI in pregnant females in Pakistan. Read More

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September 2018
3 Reads

Atypical Hemolytic Uremic Syndrome Presenting as Pre-eclampsia in a 24-year-old Woman with Chronic Kidney Disease: Pathogenesis and Genetics.

Cureus 2018 Sep 25;10(9):e3358. Epub 2018 Sep 25.

Internal Medicine, Brookdale University Hospital, New York, USA.

Atypical hemolytic uremic syndrome (aHUS) is a kidney disorder that is frequently unrecognized during its progression, and misdiagnosed with more common etiologies of microangiopathic hemolytic anemia (MAHA): hemolytic uremic syndrome, disseminated intravascular coagulation, and thrombotic thrombocytopenic purpura (TTP). During pregnancy, the diagnosis of aHUS is furthermore challenging. The clinical presentation of aHUS may mimic pre-eclampsia as it occurred to the patient described in the case report. Read More

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September 2018
1 Read

Placenta Accreta: A Spectrum of Predictable Risk, Diagnosis, and Morbidity.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

Objective:  Placenta accreta is a feared pathology, in part, because prenatal diagnosis is imperfect. It is not known whether clinical risk factors or sonographic features equally predict the entire graded pathological spectrum of placental overinvasion disease nor whether clinical outcomes differ along the spectrum.

Study Design:  We conducted a mixed methods retrospective study of a cohort of women screened sonographically for placenta accreta, cross-referenced against cases identified by pathological diagnosis ( = 416). Read More

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November 2018
1 Read

Early Pregnancy Hemoglobin A1C and Pregnancy Outcomes: A Population-Based Study.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Objectives:  Women with prediabetes are identified from screening for overt diabetes in early pregnancy, but the clinical significance of prediabetes in pregnancy is unclear. We examined whether prediabetes in early pregnancy was associated with risks of adverse outcomes.

Study Design:  We conducted a retrospective cohort study of pregnant women enrolled in Kaiser Permanente Washington from 2011 to 2014. Read More

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November 2018
1 Read

The association between vascular complications during pregnancy in women with Type 1 diabetes and congenital malformations.

Diabet Med 2018 Nov 30. Epub 2018 Nov 30.

Departments of Medicine, University of Calgary, Calgary Alberta, Canada.

Aims: To assess the association between vascular complications of diabetes and the risk of congenital malformations in pregnant women with Type 1 diabetes.

Methods: We conducted an observational retrospective cohort study in women with Type 1 diabetes who received care consecutively from three tertiary care diabetes-in-pregnancy clinics in Calgary, Alberta, Canada. Multivariable logistic regression was used to assess the association between vascular complications (retinopathy, nephropathy and pre-existing hypertension) and congenital malformations in offspring of women with Type 1 diabetes. Read More

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November 2018

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy.

Front Immunol 2018 15;9:2628. Epub 2018 Nov 15.

Department of Comparative Biosciences, Wisconsin National Primate Research Center, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.

Hofbauer cells are placental villous macrophages of fetal origin that are present throughout pregnancy. Although Hofbauer cell populations are antigenically and morphologically heterogeneous, their epigenetic, antigenic, and functional profiles most closely resemble alternatively activated macrophages or what are referred to as M2a, M2b, M2c, and M2d polarity subtypes. Consistent with an M2-like profile, these cells play an important role in placental development including vasculogenesis and angiogenesis. Read More

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November 2018
1 Read

Mitochondria and Coenzyme Q10 in the Pathogenesis of Preeclampsia.

Front Physiol 2018 15;9:1561. Epub 2018 Nov 15.

Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador.

Hypertensive disorders during pregnancy constitute one of the main causes of maternal and perinatal morbidity and mortality across the world and particularly in developing countries such as Ecuador. However, despite its impact on public health, the primary pathophysiological processes involved are yet to be elucidated. It has been proposed, among other theories, that an abnormal placentation may induce an endothelial dysfunction, which is ultimately responsible for the final clinical manifestations. Read More

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November 2018

Chronic renal disease and antenatal care.

Authors:
Matt Hall

Best Pract Res Clin Obstet Gynaecol 2018 Oct 30. Epub 2018 Oct 30.

Nottingham Renal and Transplant Unit, City Campus, Nottingham University Hospitals, Hucknall Road, Nottingham, NG5 1PB, UK. Electronic address:

In 2018, it is unusual for women with chronic kidney disease (CKD) to be told that pregnancy is not an option. Maternal and foetal outcomes have steadily improved over the last 50 years and a successful pregnancy, resulting in a healthy infant without detrimental to maternal health, is commonplace. Nevertheless, the incidence of adverse outcomes including pre-eclampsia, preterm birth and small-for-gestational age infants is higher for women with CKD than the general population, requiring enhanced monitoring. Read More

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October 2018

Association between endoglin/transforming growth factor beta receptors 1, 2 gene polymorphisms and the level of soluble endoglin with preeclampsia in Egyptian women.

Arch Biochem Biophys 2018 Nov 27;662:7-14. Epub 2018 Nov 27.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, 11562, Egypt. Electronic address:

Introduction: Preeclampsia (PE) is a pregnancy-specific hypertensive disease whose etiopathogenesis remains unclear.

Objectives: This study was designed to assess association between PE and 3 single nucleotide polymorphisms (SNPs): ENG(G/A) rs11792480, TGFβR1(A/C) rs10739778 and TGFβR2(G/A) rs6550005, beside circulating soluble endoglin (sENG), oxidative stress biomarkers and nitric oxide (NO) in Egyptian women.

Methods: The study included 75 preeclamptic women stratified into 4 clinical subgroups and 50 normotensive pregnant women. Read More

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November 2018

Stillbirths in women with pre-gravid obesity.

J Perinat Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynecology, Kaplan Medical Center, affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Rehovot, Israel.

Objective To determine the association between pre-gravid obesity and stillbirth. Methods A retrospective study of a population-based dataset of births at ≥34 weeks' gestation. We excluded fetal deaths due to lethal anomalies and intrapartum fetal deaths. Read More

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November 2018
1 Read

Amphetamine- and Opioid-Affected Births: Incidence, Outcomes, and Costs, United States, 2004-2015.

Am J Public Health 2018 Nov 29:e1-e7. Epub 2018 Nov 29.

Lindsay K. Admon and Vanessa K. Dalton are with the Department of Obstetrics and Gynecology at the University of Michigan, Ann Arbor. L. K. Admon was also with the US Department of Veterans Affairs, Ann Arbor, at the time this work was completed. Caroline R. Richardson is with the Department of Family Medicine at the University of Michigan. Katy B. Kozhimannil is with the Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis. Gavin Bart is with the Division of Addiction Medicine, Department of Medicine at Hennepin Healthcare, Minneapolis. Tyler N. A. Winkelman is in the Division of General Internal Medicine and the Hennepin Healthcare Research Institute, Hennepin Healthcare.

Objectives: To estimate trends in incidence, outcomes, and costs among hospital deliveries related to amphetamines and opioids.

Methods: We analyzed 2004-to-2015 data from the National Inpatient Sample, a nationally representative sample of hospital discharges in the United States compiled by the Healthcare Cost and Utilization Project, by using a repeated cross-sectional design. We estimated the incidence of hospital deliveries related to maternal amphetamine or opioid use with weighted logistic regression. Read More

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November 2018

Are the Cognitive Alterations Present in Children Born From Preeclamptic Pregnancies the Result of Impaired Angiogenesis? Focus on the Potential Role of the VEGF Family.

Front Physiol 2018 14;9:1591. Epub 2018 Nov 14.

Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (LFV-GIANT), Department of Basic Sciences, Faculty of Basic Sciences, Universidad del Bío-Bío, Chillán, Chile.

Evidence from clinical studies has proposed that children born from preeclamptic women have a higher risk of suffering neurological, psychological, or behavioral alterations. However, to date, the mechanisms behind these outcomes are poorly understood. Here, we speculate that the neurodevelopmental alterations in the children of preeclamptic pregnancies result from impaired angiogenesis. Read More

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November 2018

Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia.

Cell Mol Immunol 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, 210008, Nanjing, China.

The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia (PE), in which an imbalance between the inflammation-limiting regulatory T cells (Tregs) and the inflammation-mediating Th17 cells plays an essential role. Previously, we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells (fetal component) participated in the pathogenesis of PE. However, as one of the potential immune regulatory molecules, whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified. Read More

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November 2018

Local validation and calibration of preeclampsia screening algorithms.

Authors:
Howard Cuckle

Ultrasound Obstet Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.

A recent Practice Guideline issued by the International Society of Ultrasound in Obstetrics and Gynecology recommends a combination of a priori factors and pregnancy-specific makers, determined at 11-13 weeks gestation, as the most efficient method of identifying women at risk of preeclampsia (PE) [1]. This article is protected by copyright. All rights reserved. Read More

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November 2018

Correlation between uterine artery Doppler and the sFlt-1/PlGF ratio in different phenotypes of placental dysfunction.

Hypertens Pregnancy 2018 Nov 28:1-9. Epub 2018 Nov 28.

a Department of Perinatology, Division of Obstetrics and Gynecology , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Objective: To explore correlations between the sFlt-1/PlGF ratio and uterine arteries (UtA) Doppler indexes in placental dysfunction-related disorders (PDD).

Methods: We prospectively included women with a singleton pregnancy with preeclampsia (PE) only (n = 22), preeclampsia with fetal growth restriction (FGR) (n = 32), FGR only (n = 12), or normal pregnancy (n = 29).

Results: In PDDs, significantly positive correlations between the sFlt-1/PlGF ratio and the mean UtA pulsatility (mPI-UtA), as well as the resistance index (mRI-UtA) were found (p = 0. Read More

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November 2018

Alarmins at the maternal-fetal interface: involvement of inflammation in placental dysfunction and pregnancy complications.

Can J Physiol Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Universite de Montreal, Obstetrics & Gynecology , 3175 Chemin de la Cote Ste-Catherine , Montreal, Quebec, Canada , H3T1C5.

Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of non-infectious origin, namely caused by endogenous mediators known as "damage-associated molecular patterns - DAMPs" or alarmins. Read More

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November 2018

Obstructive sleep apnea as a risk factor for preeclampsia-eclampsia.

Sleep Breath 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology, Maharat Nakhon Ratchasima Hospital, Amphoe Mueang Nakhon Ratchasima, Nakhon Ratchasima Province, Thailand.

Purpose: Preeclampsia-eclampsia remains one of the leading causes of maternal and perinatal morbidity and mortality. Emerging evidence suggests that obstructive sleep apnea (OSA), which has been linked to hypertension in the general population, may play role in hypertensive disorders in pregnancy, including preeclampsia-eclampsia. However, little research has been conducted in Asia (no data in Thailand) on the effects of OSA on preeclampsia-eclampsia. Read More

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November 2018
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The Immunogenetic Conundrum of Preeclampsia.

Front Immunol 2018 13;9:2630. Epub 2018 Nov 13.

Medical and Clinical genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. Read More

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November 2018

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment.

Front Immunol 2018 13;9:2597. Epub 2018 Nov 13.

Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is critical for adapting blood flow and nutrient transport to the developing fetus. Failures in this process have been noticed in different pregnancy complications such as preeclampsia, intrauterine growth restriction, stillbirth, or recurrent abortion. Read More

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November 2018