214,456 results match your criteria Practical Diabetology Diabetologia Praktyczna[Journal]


Using specialist screening practitioners (SSPs) to increase uptake of bowel scope (flexible sigmoidoscopy) screening: results of a feasibility single-stage phase II randomised trial.

BMJ Open 2019 Feb 15;9(2):e023801. Epub 2019 Feb 15.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objective: To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment.

Design: A single-stage phase II trial.

Setting: South Tyneside District Hospital, Tyne and Wear, England, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023801DOI Listing
February 2019

Importance of sperm density in assessing the toxicity of metals to the fertilization of broadcast spawners.

Ecotoxicol Environ Saf 2019 Feb 14;172:547-555. Epub 2019 Feb 14.

Faculty of Engineering Sciences, University College London, GPO Box 2471, Adelaide SA 5001, Australia.

Many marine invertebrates reproduce through broadcast spawning, where sperm and eggs are released into the water column and are vulnerable to toxicants present in the environment. The potential impacts of toxicants on spawning success are often assessed through laboratory-based fertilization tests. In most cases, these tests assess toxicant impacts at a single, pre-defined sperm density, based on a sperm:egg ratio that ensures high fertilization success (≥70-80%) in a filtered seawater control. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.053DOI Listing
February 2019

Increasing nursing students' knowledge of evidence-based hand-hygiene: A quasi-experimental study.

Nurse Educ Pract 2019 Jan 2;35:104-110. Epub 2019 Jan 2.

Department of Children and Women, Oulu University Hospital, Finland. Electronic address:

Aim of study was to evaluate the effects of a multi-component intervention on nursing students' knowledge of evidence-based hand-hygiene. A quasi-experimental design was used. Nursing students (N = 146) from two universities of applied sciences (experimental group n = 107, control group n = 39) completed an instrument based on international clinical guidelines related to hand hygiene that consisted of 17 Likert-scale items. Read More

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http://dx.doi.org/10.1016/j.nepr.2018.12.009DOI Listing
January 2019

Single-trial estimation of quasi-static EMG-to-joint-mechanical-impedance relationship over a range of joint torques.

J Electromyogr Kinesiol 2019 Feb 8;45:18-25. Epub 2019 Feb 8.

Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA. Electronic address:

Joint mechanical impedance is commonly measured by applying dynamic perturbations about a joint at a fixed operating point/background torque, and quantifying torque change vs. angle change. Impedance characterization in functional tasks, therefore, requires multiple experimental trials over a range of operating points-a cumbersome, invasive, time-consuming and impractical task. Read More

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http://dx.doi.org/10.1016/j.jelekin.2019.02.001DOI Listing
February 2019

Sulfidation of ZVI/AC composite leads to highly corrosion-resistant nanoremediation particles with extended life-time.

Sci Total Environ 2019 Feb 10;665:235-245. Epub 2019 Feb 10.

Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Engineering, D-04318 Leipzig, Germany. Electronic address:

Nanoscale zero-valent iron (nZVI) is a powerful reductant for many water pollutants. The lifetime of nZVI in aqueous environments is one of its limitations. Sulfidation of the nZVI surface by reduced sulfur species is known to significantly modify the particle properties. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.136DOI Listing
February 2019

One-pot solvothermal synthesis of reduced graphene oxide-supported uniform PtCo nanocrystals for efficient and robust electrocatalysis.

J Colloid Interface Sci 2019 Jan 28;543:17-24. Epub 2019 Jan 28.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

Pt-based nanocomposites with low Pt utilization and high-activity by incorporating with other transition metals have received significant interest in catalysis. Meanwhile, loading Pt-based catalysts on graphene has great research value for improved stability and dispersity of the catalysts. Herein, a facile l-proline-mediated solvothermal strategy was reported to construct reduced graphene oxide (rGO) supported sheet-like PtCo nanocrystals (PtCo NCs/rGO) in ethylene glycol (EG). Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.110DOI Listing
January 2019

One-pot aqueous synthesis of two-dimensional porous bimetallic PtPd alloyed nanosheets as highly active and durable electrocatalyst for boosting oxygen reduction and hydrogen evolution.

J Colloid Interface Sci 2019 Jan 29;543:1-8. Epub 2019 Jan 29.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

Recently, two-dimensional materials have gained increasing research attention due to their large surface area, high physical and chemical stability, and excellent electrocatalytic performances. Herein, we reported a simple and fast one-pot aqueous method for synthesis of two-dimensional porous bimetallic PtPd alloyed nanosheets (NSs) using benzyldimethylhexadecylammonium chloride (HDBAC) as the capping agent and stabilizer. The formation mechanism involved the oriented attachment and self-assembly. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.122DOI Listing
January 2019

Environmentally benign synthesis of CoO-SnO heteronanorods with efficient photocatalytic performance activated by visible light.

J Colloid Interface Sci 2019 Jan 22;542:460-468. Epub 2019 Jan 22.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, People's Republic of China. Electronic address:

One-dimensional (1D) heterostructured photocatalysts with controllable texture properties and compositions have attracted increasing interest owing to their unique optical, structural, and electronic advantages. Herein, 1D CoO-SnO heteronanorods were rationally designed and synthesized through a facile solution-based approach. Benefiting from both of their heterostructural and compositional characteristics, the resulting CoO-SnO heteronanorods exhibit high photocatalytic performance for the degradation of Rhodamine B (RhB) under visible-light irridation. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.089DOI Listing
January 2019

Quantitative measurement of nanoscale electrostatic potentials and charges using off-axis electron holography: Developments and opportunities.

Ultramicroscopy 2019 Feb 10. Epub 2019 Feb 10.

Department of Physics, Arizona State University, Tempe, AZ 85287, USA.

Off-axis electron holography has evolved into a powerful electron-microscopy-based technique for characterizing electromagnetic fields with nanometer-scale resolution. In this paper, we present a review of the application of off-axis electron holography to the quantitative measurement of electrostatic potentials and charge density distributions. We begin with a short overview of the theoretical and experimental basis of the technique. Read More

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http://dx.doi.org/10.1016/j.ultramic.2019.01.008DOI Listing
February 2019

[The age of artificial intelligence in lung cancer pathology: Between hope, gloom and perspectives].

Ann Pathol 2019 Feb 13. Epub 2019 Feb 13.

Laboratoire de pathologie clinique et expérimentale/biobanque (BB 0033-00025), Fédération hospitalo-universitaire OncoAge, CHU de Nice, université Côte-d'Azur, 30, voie Romaine, 06000 Nice, France; Équipe 4, CNRS UMR7284, Inserm U1081, faculté de médecine, institut de recherche sur le cancer et le vieillissement de Nice (Ircan), 28, avenue de Valombrose, 06107 Nice, France. Electronic address:

Histopathology is the fundamental tool of pathology used for more than a century to establish the final diagnosis of lung cancer. In addition, the phenotypic data contained in the histological images reflects the overall effect of molecular alterations on the behavior of cancer cells and provides a practical visual reading of the aggressiveness of the disease. However, the human evaluation of the histological images is sometimes subjective and may lack reproducibility. Read More

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http://dx.doi.org/10.1016/j.annpat.2019.01.003DOI Listing
February 2019

Novel color standards for digital color analysis of optochemical sensor arrays.

Talanta 2019 May 17;197:638-644. Epub 2019 Jan 17.

Chemistry Institute, Saint Petersburg State University, 26 Universitetskiy prospect, 198504 Saint Petersburg, Russia.

The indicator-based polymeric color standards for color referencing in digital color analysis (DCA) of optical chemical sensors (optodes) are proposed. In the novel standards, the colors referring to the actual absorption bands of the protonated and deprotonated forms of the indicator are mixed in constant proportions. The standards are based on the lipophilic pH-indicators: ETH5350 and ETH2439, commonly used in optodes, and the lipophilic electrolyte TBATBB. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.063DOI Listing

The paramagnetic properties of malaria pigment, hemozoin, yield clues to a low-cost system for its trapping and determination.

Talanta 2019 May 25;197:553-557. Epub 2019 Jan 25.

Service de Chimie Thérapeutique et de Pharmacognosie, Université de Mons (UMONS), Bât. 6, Chemin du Champ de Mars 25, 7000 Mons, Belgium. Electronic address:

The binding of malaria pigment, hemozoin, by a gradient magnetic field has been investigated in a manual trapping column system. Two types of magnetic filling have been tested to produce field gradients: nickel-plated steel wires, wrapped around a steel core, and superparamagnetic microbeads. The latter system allows an efficient trapping (> 80%) of β-hematin (a synthetic pigment with physical and paramagnetic properties analogous to those of hemozoin). Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.090DOI Listing

Volatile aldehydes sensing in headspace using a room temperature ionic liquid-modified electrochemical microprobe.

Talanta 2019 May 14;197:522-529. Epub 2019 Jan 14.

Department of Molecular Sciences and Nanosystems, University Cà Foscari Venice, via Torino, 155, I-30137 Mestre-Venezia, Italy. Electronic address:

The cyclic voltammetric behaviour of propionaldehyde (PA) and hexanaldehyde (HA), in 1-butyl-3-methylimidazolium bis(trifluoromethyl-sulfonyl) imide ([BMIM][NTF]), 1-butyl-3-methylimidazolium hydrogen sulphate ([BMIM][HSO]) and 1-butyl-3-methylimidazolium hydroxide ([BMIM][OH]) was investigated at a platinum microelectrode. A clear oxidation process for both aldehydes was recorded only in [BMIM][OH]. On the basis of these evidences, an electrochemical microprobe (EMP), incorporating [BMIM][OH] as electrolyte, was assembled for sensing these aldehydes in gaseous phases. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.049DOI Listing

Quantifying the organic content of saline wastewaters: Is chemical oxygen demand always an achievable parameter?

Talanta 2019 May 9;197:509-516. Epub 2019 Jan 9.

Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran.

The study presented in this paper takes a comprehensive approach to the measurement of the COD of saline industrial wastewaters taking into account both their widely varying salinity levels and the substantial interference of chloride with the conventional method of COD measurement. To this end, three approaches for combating the chloride interference associated with the measurement of COD using the conventional method were considered. The dilution of saline samples prior to analysis yielded reasonably accurate COD results as long as the COD after dilution was 40 mg L or above. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.028DOI Listing

A new double-emission fluorescent probe for fast detection of thiophenols in aqueous solution and living cells.

Talanta 2019 May 8;197:204-210. Epub 2019 Jan 8.

Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address:

A new fluorescent probe was designed and synthesized according to the photo-induced electron transfer theory (PET) and the results of density functional theory calculation. The synthesized probe had a larger Stokes shift (130 nm) and double emission peak in response to highly toxic thiophenols, which could be applied in rapid and high sensitive detection of thiophenol in aqueous solution. A 25-fold fluorescence intensity enhancement was achieved and the fluorescent intensity at 460 nm had a linear relationship to the thiophenol in concentration range of 0-2. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.022DOI Listing

[Early prevention and nutritional education].

Soins 2019 Jan - Feb;64(832):25-28

Institut Pasteur de Lille, 1, rue du professeur-Calmette, 59000 Lille, France. Electronic address:

To be effective, prevention must not remain a theoretical concept and its implementation must not be perceived negatively. Ignorance and prejudices need to be overcome. From conception to adolescence, simple and easy-to-follow nutritional education measures, as well as practical and concrete advice, can be easily applied. Read More

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http://dx.doi.org/10.1016/j.soin.2018.12.005DOI Listing
February 2019

Hexavalent chromium remediation based on the synergistic effect between chemoautotrophic bacteria and sulfide minerals.

Ecotoxicol Environ Saf 2019 Feb 13;173:118-130. Epub 2019 Feb 13.

School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha 410083, China.

Hexavalent chromium (Cr(VI)) is an environmental concern due to the carcinogenic and mutagenic effect on living organisms. Sulfide minerals based Cr(VI) reduction is an economical and efficient strategy for Cr(VI) remediation. In this study, Cr(VI) reduction through the synergistic effect between chemoautotrophic bacteria and sulfide mineral is systematically investigated. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.079DOI Listing
February 2019

A simple benzimidazole styryl-based colorimetric chemosensor for dual sensing application.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 7;214:111-118. Epub 2019 Feb 7.

Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address:

A new colorimetric styryl-benzimidazole based receptor to recognize more than one analyte trans-2-[4'-(dimethylamino)styryl]benzimidazole) (L1) has been synthesized and fully characterized by C and H NMR, elemental analysis, UV-vis spectroscopy, and HRMS. Investigation of sensing ability of receptor L1 was carried out in presence of multiple anions (Br, CN, Cl, ClO, F, HSO, PF, NO, S, OH, AcO and HPO) and cations (Cu, Cr, Al, Mg, Cd, Ni, Fe, K, Fe, Mn, Ag, Hg, Ca, Co, Pb, Na, and Zn) by using UV-vis spectroscopy. Receptor L1 showed colorimetric response towards only for HSO ion. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.009DOI Listing
February 2019

iTRAQ-based proteome profiling of hyposaline responses in zygotes of the Pacific oyster Crassostrea gigas.

Comp Biochem Physiol Part D Genomics Proteomics 2018 Dec 11;30:14-24. Epub 2018 Dec 11.

Fisheries College, Ocean University of China, Qingdao, Shandong, China.

Low salinity treatment is proven to be the practical polyploidy inducing method for shellfish with advantages of lower cost, higher operability and reliable food security. However, little is known about the possible molecular mechanism of hypotonic induction. In this study, isobaric tags for relative and absolute quantitation (iTRAQ) based proteomic profiling was pursued to investigate the responses of zygotes of the Pacific oyster Crassostrea gigas to low salinity. Read More

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http://dx.doi.org/10.1016/j.cbd.2018.12.003DOI Listing
December 2018

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Marine Evolution and Conservation, Groningen Institute of Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands; Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, United States of America. Electronic address:

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.003DOI Listing
February 2019

Toxicological assessment compilation of selected examples of raw materials for homeopathic medicinal products.

Regul Toxicol Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.02.007DOI Listing
February 2019

Radiation dose in nuclear medicine: the hybrid imaging.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Rome, Italy.

Hybrid imaging procedures such as single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT) showed a rapid diffusion in recent years because of their high sensitivity, specificity, and accuracy, due to a more accurate localization and definition of scintigraphic findings. However, hybrid systems inevitably lead to an increase in patient radiation exposure because of the added CT component. Effective doses due to the radiopharmaceuticals can be estimated by multiplying the administered activities by the effective dose coefficients, while for the CT component the dose-length product can be multiplied by a conversion coefficient k. Read More

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http://dx.doi.org/10.1007/s11547-019-00989-yDOI Listing
February 2019

Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.

Theor Med Bioeth 2019 Feb 15. Epub 2019 Feb 15.

Macquarie University, North Ryde, NSW, Australia.

Personalised medicine (PM) has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells (iPSCs) so as to make individualised treatment predictions. Read More

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http://dx.doi.org/10.1007/s11017-019-09482-zDOI Listing
February 2019

Perianal sepsis: surgical perspective and practical MRI reporting for radiologists.

Abdom Radiol (NY) 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Concord Repatriation General Hospital, Concord Clinical School, Sydney Medical School, University of Sydney, Concord, NSW, 2137, Australia.

This article describes the development of a structured MRI reporting template and diagrammatic worksheet for perianal sepsis through collaboration between radiologists and colorectal surgeons at our institution, and the rationale behind each component of the worksheet. Benefits of this reporting worksheet include optimizing communication of key imaging findings that have a real impact on patient management, less time spent on reporting the study, and easier comparison between studies. We illustrate the utility of the report template with case studies. Read More

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http://dx.doi.org/10.1007/s00261-019-01920-9DOI Listing
February 2019

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.

Lab Invest 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies. These tauopathies have diverse and overlapping morphological phenotypes that obscure classification and quantitative assessments. Recently, powerful machine learning-based approaches have emerged, allowing the recognition and quantification of pathological changes from digital images. Read More

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http://dx.doi.org/10.1038/s41374-019-0202-4DOI Listing
February 2019

Oxygen vacancy associated single-electron transfer for photofixation of CO to long-chain chemicals.

Nat Commun 2019 Feb 15;10(1):788. Epub 2019 Feb 15.

Hefei National Laboratory for Physical Sciences at the Microscale, Collaborative Innovation Center of Chemistry for Energy Materials, University of Science and Technology of China, Hefei, 230026, P.R. China.

The photofixation and utilization of CO via single-electron mechanism is considered to be a clean and green way to produce high-value-added commodity chemicals with long carbon chains. However, this topic has not been fully explored for the highly negative reduction potential in the formation of reactive carbonate radical. Herein, by taking BiO nanosheets as a model system, we illustrate that oxygen vacancies confined in atomic layers can lower the adsorption energy of CO on the reactive sites, and thus activate CO by single-electron transfer in mild conditions. Read More

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http://dx.doi.org/10.1038/s41467-019-08697-xDOI Listing
February 2019

Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles.

Nat Commun 2019 Feb 15;10(1):768. Epub 2019 Feb 15.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.

The exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Read More

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http://www.nature.com/articles/s41467-019-08722-z
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http://dx.doi.org/10.1038/s41467-019-08722-zDOI Listing
February 2019
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A systematic review of multi-level stigma interventions: state of the science and future directions.

BMC Med 2019 Feb 15;17(1):41. Epub 2019 Feb 15.

Department of Health Behavior, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

Background: Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural levels. While existing interventions have produced modest reductions in stigma, their full reach and impact remain limited by a nearly exclusive focus targeting only one level of analysis.

Methods: We conducted the first systematic review of original research on multi-level stigma-reduction interventions. Read More

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http://dx.doi.org/10.1186/s12916-018-1244-yDOI Listing
February 2019

A new prokaryotic expression vector for the expression of antimicrobial peptide abaecin using SUMO fusion tag.

BMC Biotechnol 2019 Feb 15;19(1):13. Epub 2019 Feb 15.

MicroSynbiotiX Ltd, 11011 N Torrey Pines Rd Ste. #135, La Jolla, CA, 92037, USA.

Background: Despite the growing demand for antimicrobial peptides (AMPs) for clinical use as an alternative approach against antibiotic-resistant bacteria, the manufacture of AMPs relies on expensive, small-scale chemical methods. The small ubiquitin-related modifier (SUMO) tag is industrially practical for increasing the yield of recombinant proteins by increasing solubility and preventing degradation in expression systems.

Results: A new vector system, pKSEC1, was designed to produce AMPs, which can work in prokaryotic systems such as Escherichia coli and plant chloroplasts. Read More

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http://dx.doi.org/10.1186/s12896-019-0506-xDOI Listing
February 2019

Parameter estimation in models of biological oscillators: an automated regularised estimation approach.

BMC Bioinformatics 2019 Feb 15;20(1):82. Epub 2019 Feb 15.

(Bio)Process Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain.

Background: Dynamic modelling is a core element in the systems biology approach to understanding complex biosystems. Here, we consider the problem of parameter estimation in models of biological oscillators described by deterministic nonlinear differential equations. These problems can be extremely challenging due to several common pitfalls: (i) a lack of prior knowledge about parameters (i. Read More

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http://dx.doi.org/10.1186/s12859-019-2630-yDOI Listing
February 2019

[Application Status and Development Trends of Medical Proton and Heavy Ion Accelerators].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):37-42

School of Mechanical and Electronical Engineering, Lanzhou University of Technology, Lanzhou, 730050.

Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.010DOI Listing
January 2019

All Non-Carbon B3NO2 Exotic Heterocycle: Synthesis, Dynamics, and Catalysis.

Chemistry 2019 Feb 15. Epub 2019 Feb 15.

Institute of Microbial Chemistry, Department of Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, JAPAN.

The B3NO2 six-membered heterocycle (1,3-dioxa-5-aza-2,4,6-triborinane: DATB), comprising of three different non-carbon second-row elements, was recently demonstrated to be a powerful catalyst for dehydrative condensation of carboxylic acids and amines. The tedious synthesis of DATB, however, significantly diminished its utility as a catalyst, and thus the inherent chemical properties of the ring system remained virtually unexplored. Herein we disclose a general and facile synthetic strategy that harnesses a pyrimidine-containing scaffold for the reliable installation of boron atoms, giving rise to a series of Pym-DATBs from inexpensive materials in a modular fashion. Read More

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http://dx.doi.org/10.1002/chem.201900715DOI Listing
February 2019

Validity and reliability of lower-limb pulse-wave velocity assessments using an oscillometric technique.

Exp Physiol 2019 Feb 16. Epub 2019 Feb 16.

Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, USA.

New Findings: What is the central question of this study? There is growing interest on the effects of sedentarism on central and peripheral cardiovascular health. To permit further investigation, including in larger epidemiological studies, there is a need to identify arterial health assessment tools that are valid (accurate) and reliable (precise), yet practical. What is the main finding and its importance? Lower-limb vascular health (femoral-ankle pulse-wave velocity) can be determined in a supine position with accuracy and precision using an oscillometric-based device. Read More

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http://dx.doi.org/10.1113/EP087444DOI Listing
February 2019

The tissue viability imaging system-Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross-sectional field study.

Skin Res Technol 2019 Feb 16. Epub 2019 Feb 16.

Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: For early detection of initial skin changes in occupational screenings, only few objective assessment systems are available.

Objectives: With the aim of assessing an objective measurement method for hand eczema, we trialed the application of the tissue viability imaging (TiVi) system, quantifying erythema non-invasively by polarized light spectroscopy.

Materials And Methods: In a field study with 625 employees of a semiconductor production company, 411 were exposed to prolonged wearing of occlusive gloves in the clean room. Read More

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http://dx.doi.org/10.1111/srt.12686DOI Listing
February 2019

Exploring barriers and challenges in protecting residential fire-related injuries: a qualitative study.

J Inj Violence Res 2019 Feb 16;11(1). Epub 2019 Feb 16.

Safety Promotion and Injury Prevention Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Building fires can be a great threat to the safety of residents, and can lead to economic and social damage. Exploring the views of stakeholders is a great source for understanding the factors that affect fires. The purpose of this study was to explore stakeholders' experiences of unintentional fire-related injuries in residential buildings in Iran. Read More

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http://dx.doi.org/10.5249/jivr.v11i1.1059DOI Listing
February 2019

Asbestos neglect: Why asbestos exposure deserves greater policy attention.

Health Policy 2019 Feb 7. Epub 2019 Feb 7.

Interface Demography, Sociology Department, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:

While many public health threats are now widely appreciated by the public, the risks from asbestos exposure remain poorly understood, even in high-risk groups. This article makes the case that asbestos exposure is an important, ongoing global health threat, and argues for greater policy efforts to raise awareness of this threat. It also proposes the extension of asbestos bans to developing countries and increased public subsidies for asbestos testing and abatement. Read More

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http://dx.doi.org/10.1016/j.healthpol.2019.02.001DOI Listing
February 2019

Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging.

J Sex Med 2019 Feb;16(2):338-345

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim: To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods: Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.015DOI Listing
February 2019

Invariance of experimental observables with respect to coarse-graining in standard and many-body dissipative particle dynamics.

J Chem Phys 2019 Feb;150(6):064101

Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, United Kingdom.

Dissipative particle dynamics (DPD) is a well-established mesoscale simulation method. However, there have been long-standing ambiguities regarding the dependence of its (purely repulsive) force field parameter on temperature as well as the variation of the resulting experimental observables, such as diffusivity or surface tension, with coarse-graining (CG) degree. Here, we rederive the temperature dependence of DPD interaction parameter and revisit the role of the CG degree in standard DPD simulations. Read More

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http://dx.doi.org/10.1063/1.5046851DOI Listing
February 2019

Heat Stress in Indoor Environments of Scandinavian Urban Areas: A Literature Review.

Int J Environ Res Public Health 2019 Feb 15;16(4). Epub 2019 Feb 15.

Ergonomics and Aerosol Technology, Department of Design Sciences, Lund University, 221 00 Lund, Sweden.

Climate change increases the risks of heat stress, especially in urban areas where urban heat islands can develop. This literature review aims to describe how severe heat can occur and be identified in urban indoor environments, and what actions can be taken on the local scale. There is a connection between the outdoor and the indoor climate in buildings without air conditioning, but the pathways leading to the development of severe heat levels indoors are complex. Read More

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http://dx.doi.org/10.3390/ijerph16040560DOI Listing
February 2019

Positioning, Navigation, and Book Accessing/Returning in an Autonomous Library Robot using Integrated Binocular Vision and QR Code Identification Systems.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.

With rapid advancements in artificial intelligence and mobile robots, some of the tedious yet simple jobs in modern libraries, like book accessing and returning (BAR) operations that had been fulfilled manually before, could be undertaken by robots. Due to the limited accuracies of the existing positioning and navigation (P&N) technologies and the operational errors accumulated within the robot P&N process, however, most of the current robots are not able to fulfill such high-precision operations. To address these practical issues, we propose, for the first time (to the best of our knowledge), to combine the binocular vision and Quick Response (QR) code identification techniques together to improve the robot P&N accuracies, and then construct an autonomous library robot for high-precision BAR operations. Read More

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http://dx.doi.org/10.3390/s19040783DOI Listing
February 2019

The Good, the Bad, and the Ugly: "HiPen", a New Dataset for Validating (S)QM/MM Free Energy Simulations.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL 33620, USA.

Indirect (S)QM/MM free energy simulations (FES) are vital to efficiently incorporating sufficient sampling and accurate (QM) energetic evaluations when estimating free energies of practical/experimental interest. Connecting between levels of theory, i.e. Read More

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http://dx.doi.org/10.3390/molecules24040681DOI Listing
February 2019

Electrospun Polylactic Acid (PLLA) Microtube Array Membrane (MTAM)-An Advanced Substrate for Anticancer Drug Screening.

Materials (Basel) 2019 Feb 14;12(4). Epub 2019 Feb 14.

Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Xinyi District, Taipei 11031, Taiwan.

The advent of personalized cancer treatment resulted in the shift from the administration of cytotoxic drugs with broad activity spectrum to a targeted tumor-specific therapy. Aligned to this development, the focus of this study revolved around the application of our novel and patented microtube array membrane (MTAM) in the US National Cancer Institute (NCI) developed an HFA (hollow fiber assay) assay; hereinafter known as MTAM/HFA. Electrospun poly-L-lactic acid (PLLA) MTAM was sterilized and loaded with cell lines/patient derived tumor cells (PDTC) and subcutaneously implanted into the backs of BALB/C mice. Read More

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http://dx.doi.org/10.3390/ma12040569DOI Listing
February 2019

Optical Oxygen Sensing with Artificial Intelligence.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

TOELT LLC, Birchlenstr. 25, 8600 Dübendorf, Switzerland.

Luminescence-based sensors for measuring oxygen concentration are widely used in both industry and research due to the practical advantages and sensitivity of this type of sensing. The measuring principle is the luminescence quenching by oxygen molecules, which results in a change of the luminescence decay time and intensity. In the classical approach, this change is related to an oxygen concentration using the Stern-Volmer equation. Read More

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http://dx.doi.org/10.3390/s19040777DOI Listing
February 2019

DFT computational schemes for N NMR chemical shifts of the condensed nitrogen containing heterocycles.

Magn Reson Chem 2019 Feb 15. Epub 2019 Feb 15.

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Favorsky St. 1, 664033, Irkutsk, Russian Federation.

A systematic DFT study of the accuracy factors (functionals, basis sets, solvent effects) for the computation of N NMR chemical shifts has been performed in the series of condensed nitrogen containing heterocycles. The behavior of the most representative functionals was examined based on the benchmark calculations of N NMR chemical shifts in the reference set of compounds. It was found that the best agreement with experiment was achieved with OLYP functional in combination with aug-pcS-3(N)//pc-2 locally dense basis set scheme providing MAE of 5. Read More

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http://dx.doi.org/10.1002/mrc.4851DOI Listing
February 2019

Cytotoxicity of organic and inorganic compounds to primary cell cultures established from internal tissues of Chelonia mydas.

Sci Total Environ 2019 Feb 4;664:958-967. Epub 2019 Feb 4.

Australian Rivers Institute, School of Environment and Science, Griffith University, Gold Coast, Australia.

Chemical contaminants have been found in the tissues of sea turtles from all over the world; however, very little is known about the effects. Recently, in vitro alternatives to live animal testing have been applied to sea turtles due to their ethical and practical benefits. While primary skin fibroblasts have been established for several species of sea turtle, cells from internal organs are lacking, though they may be more relevant due to the well documented accumulation of contaminants within internal tissues. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.052DOI Listing
February 2019

Towards the development of standardised sea turtle primary cell cultures for toxicity testing.

Ecotoxicol Environ Saf 2019 Feb 12;173:63-70. Epub 2019 Feb 12.

Australian Rivers Institute, School of Environment and Science, Griffith University, Gold Coast, Australia.

Chemical contaminants are known to accumulate in marine megafauna globally, but little is known about how this impacts animal health. In vitro assays offer an ethical, reproducible and cost-effective alternative to live animal toxicity testing on large, long-lived or threatened species, such as sea turtles. However, using a cell culture from a single animal raise the question of whether the toxicity observed adequately represents the toxicity in that species. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.117DOI Listing
February 2019

Psychometric Evaluation of a Measure of Factors Influencing Hand Hygiene Behaviour to Inform Intervention.

J Hosp Infect 2019 Feb 12. Epub 2019 Feb 12.

Irish Centre for Applied Patient Safety and Simulation, School of Medicine, National University of Ireland Galway, Ireland; Discipline of General Practice, School of Medicine, National University of Ireland Galway, Ireland. Electronic address:

Background: Although the hand hygiene (HH) procedure is simple, the related behaviour is complex and is not readily understood, explained, or changed. There is a need for practical tools to provide data that can guide healthcare managers and practitioners not only on the 'what' (the standards that must be met), but also the 'how' (guidance on how to achieve the standards).

Aim: To develop a valid questionnaire to evaluate attitudes to the factors that influence engagement in HH behaviour that can be readily completed, administered, and analysed by healthcare professionals to identify appropriate intervention strategies. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.003DOI Listing
February 2019

Greater palatine block for V2 trigeminal neuralgia: Case report.

Spec Care Dentist 2019 Feb 15. Epub 2019 Feb 15.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

Aims: This study describes a novel nerve block directed at the maxillary (V2) division of the fifth cranial nerve as treatment for medication-refractory trigeminal neuralgia (TN).

Methods And Results: The authors present three cases of TN treated with V2 nerve block using commonly available local anesthetics injected through the greater palatine foramen. Patients' medications were noted before and after the procedure. Read More

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http://doi.wiley.com/10.1111/scd.12365
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http://dx.doi.org/10.1111/scd.12365DOI Listing
February 2019
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Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes.

J Food Sci 2019 Feb 15. Epub 2019 Feb 15.

Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.

Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low-molecular-weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch-to-batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Read More

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http://dx.doi.org/10.1111/1750-3841.14466DOI Listing
February 2019