A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.
- Xiangzhi Meng,
- Fushun Zhang,
- Bo Yan,
- Chuanping Si,
- Hiroaki Honda,
- Akiko Nagamachi,
- Lu-Zhe Sun,
- Yan Xiang
PLoS Pathog 2018 Feb 15;14(2):e1006884. Epub 2018 Feb 15.
Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
Host restriction factors constitute a formidable barrier for viral replication to which many viruses have evolved counter-measures. Human SAMD9, a tumor suppressor and a restriction factor for poxviruses in cell lines, is antagonized by two classes of poxvirus proteins, represented by vaccinia virus (VACV) K1 and C7. A paralog of SAMD9, SAMD9L, is also encoded by some mammals, while only one of two paralogs is retained by others. Read More