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Eur Spine J 2019 Feb 15. Epub 2019 Feb 15.

Department of Histopathology, PGIMER, Chandigarh, India.

Purpose: Juvenile xanthogranuloma (JXG) presenting as solitary vertebral body lesion is infrequently seen and usually limited to one or two levels. We report a case of an isolated JXG with extensive cervical spinal (bony and extradural) involvement in a 6-year-old child. There was a diagnostic dilemma as the radiologic and intraoperative picture resembled tuberculosis. Read More

PLoS One 2019 15;14(2):e0211972. Epub 2019 Feb 15.

Field Service, National Infection Service, Public Health England, London, United Kingdom.

Recurrence of TB in an individual can occur due to relapse of the same strain or reinfection by a different strain. The contribution of reinfection and relapse to TB incidence, and the factors associated with each are unknown. We aimed to quantify and describe cases attributable to relapse or reinfection, and identify associated risk factors in order to reduce recurrence. Read More

Orthop Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedics, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: A retrospective study was designed to evaluate the effectiveness of CT-guided core needle biopsy in diagnosing spinal lesions through comparison with C-arm guidance.

Methods: From April 2013 to July 2017, a total of 188 patients, who suffered from spinal lesions or had malignant tumor history with a new spinal fracture, were included in this study. There were 96 men and 92 women, with an average of 57. Read More

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

Rev Chilena Infectol 2018 ;35(5):601-605

Servicio de Medicina Interna, Unidad de Infectología, Chile.

Detection of virus in cerebrospinal fluid (CSF) in HIV-infected patients with HIV viral load (VL) undetectable in plasma has been termed viral escape. These leaks may be asymptomatic from a neurological point of view, similar to plasma blips, or associated with neurological disease, with discordant VL between plasma and CSF, and may be evidence of a compartmentalization of the virus and the possibility of identifying quasispecies with mutations that confer resistance to ART. We present the case of a man with AIDS and disseminated tuberculosis who presented neurological symptomatology evidenced by headache and convulsive syndrome, who presented a discordance between plasma and CSF HIV VL; the genotypic test of the virus, obtained by lumbar puncture, identified new mutations that determined a change in ART with subsequent satisfactory evolution. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14196

Department of Orthopedics.

Rationale: Spinal epidural abscess (SEA) is a rare condition that shows a high prevalence in immunocompromised patients. The clinical presentation of SEA includes the "classic triad" of pain, fever, and neurological dysfunction. However, these nonspecific features can lead to a high rate of misdiagnosis. Read More

J Coll Physicians Surg Pak 2019 Feb;29(2):187-188

Department of Orthopedics, The Third People's Hospital of Shenzhen City, 518112, China.

The aim of this study was to compare clinical effect of posterior approach and anterior approach surgery for patients with thoracolumbar spinal tuberculosis. It was a descriptive, analytical study carried out at the Third People's Hospital of Shenzhen City, China, from March 2012 to March 2015. A total of 84 patients with thoracolumbar spinal tuberculosis were randomly divided into group A and group B, each group having 42 patients. Read More

JBJS Rev 2019 Jan;7(1):e9

Department of Respiratory Medicine and Infectious Diseases (V.L.C.W.) and Spinal Department (A.S.M.), Royal London Hospital, London, England.

J Orthop Surg Res 2019 Jan 22;14(1):24. Epub 2019 Jan 22.

Department of Orthopedics, Southwest Hospital, The Army (Third Military) Medical University, GaoTanYan 29, Chongqing, 400038, China.

Background: There was a controversy about surgery approach of thoracic and lumbar tuberculosis (TB) treatment. The aim of this study was to compare the microbiology outcomes of the drainage liquid and the clinical outcomes of a posterior and anterior approach in the treatment of thoracic and lumbar TB.

Materials And Methods: A total of 105 patients were enrolled in this prospective study from February 2011 to September 2015. Read More

Asian Spine J 2019 Jan 24. Epub 2019 Jan 24.

Spinal Disorder Surgery Unit, Department of Orthopaedics, Christian Medical College and Hospital, Vellore, India.

Study Design: Retrospective study.

Purpose: To report the prevalence of patients with multidrug-resistant (MDR) tubercular spondylodiscitis and their outcomes. Additionally, to assess the role of the Xpert MTB/RIF assay in early detection of MDR tuberculosis. Read More

Spine Deform 2019 Mar;7(2):356-363

Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore 641043, India.

Study Design: Single-center retrospective cohort analysis.

Objectives: To analyze the impact of loss of global lumbar lordosis (GLL) on functional outcomes in tuberculosis of the lumbar and lumbosacral spine and to define strategies to restore or preserve the physiological lumbar lordosis.

Summary Of Background Data: In tuberculosis of lumbosacral spine, loss of lumbar lordosis (LL) leads to altered lumbosacral biomechanics. Read More

Int J Paleopathol 2019 Jan 16;24:236-244. Epub 2019 Jan 16.

Department of Archaeology, Shanghai Museum, China.

The earliest evidence of human tuberculosis can be traced to at least the early dynastic periods, when full-scaled wet-rice agriculture began or entered its early developmental stages, in circum-China countries (Japan, Korea, and Thailand). Early studies indicated that the initial spread of tuberculosis coincided with the development of wet-rice agriculture. It has been proposed that the adaptation to agriculture changed human social/living environments, coincidentally favoring survival and spread of pathogenic Mycobacterial strains that cause tuberculosis. Read More

Curr Health Sci J 2018 Jul-Sep;44(3):250-260. Epub 2018 Jul 15.

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Osteoarticular tuberculosis (OATB) Aim: The authors made a clinical morphological assessment of tissue samples from patients admitted in Surgical Departments of the Emergency County Hospital of Craiova, Romania, between 1990 and 2015, proved as presenting tuberculous lesions of the spine in the Department of Pathology of the same Hospital.

Materials And Methods: The studied material consisted of bone, joint and sometimes muscle tissue fragments resulted from biopsies or surgical excisions from 7 cases coming out of 54 patients investigated in the above-mentioned period of time, where the established histological diagnosis was tuberculosis (TB). For diagnostic confirmation, Ziehl-Neelsen staining has been used as a rule but, in some cases, immunohistochemistry was also used. Read More

Neurosurg Focus 2019 Jan;46(1):E10

2Neurosurgery Department, Cairo University, Cairo, Egypt.

OBJECTIVESpontaneous spondylodiscitis remains uncommon but is a serious complication of the vertebral column. Risk factors include diabetes, hemodialysis, intravenous drug abuse, and chronic steroid use, and pain is the most common presenting symptom. This study aims to review the literature and report on the incidence, management, and clinical outcome of spontaneous spondylodiscitis in 44 patients. Read More

BMC Infect Dis 2018 Dec 27;18(1):693. Epub 2018 Dec 27.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

Background: Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic and therapeutic management.

Case Presentation: A 35-year-old male with a history of fever and back pain. Read More

Postgrad Med 2019 Jan 26;131(1):73-77. Epub 2018 Dec 26.

b Department of Orthopaedic , Third Affiliated Hospital of Southern Medical University , Guangzhou , PR China.

Objectives: Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumentation, is effective for treating MNST.

Methods: Thirteen patients, with an average age of 40. Read More

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Department of Respiratory and Sleep Medicine, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

A healthy 31-year-old man presenting with back pain was found to have multiple spinal enhancing lesions on MRI. An incidental asymptomatic large pleural effusion was identified on investigations for the back pain and pleural and pulmonary tuberculosis (TB) was subsequently diagnosed. The radiographical features on MRI spine were not typical of spinal TB and a Ga68 DOTATATE Positron Emission Tomography (PET)/CT confirmed metastatic paraganglioma with multiple bone metastases. Read More

Global Spine J 2018 Dec 13;8(4 Suppl):96S-108S. Epub 2018 Dec 13.

Ganga Hospital, Coimbatore, India.

Study Design: Review article.

Objectives: A review of literature on the epidemiology, diagnosis, and management of spinal tuberculosis (TB).

Methods: A systematic computerized literature search was performed using Cochrane Database of Systematic Reviews, EMBASE, and PubMed. Read More

BMJ Case Rep 2018 Dec 19;11(1). Epub 2018 Dec 19.

Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal.

BMJ Case Rep 2018 Dec 19;11(1). Epub 2018 Dec 19.

Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal.

We report a case of a 33-year-old woman from Nepal who presented to a hospital with paraplegia. She was found to have pulmonary tuberculosis (TB) with lumbar spine involvement, and bilateral psoas abscesses. She had no initial symptoms attributable to pulmonary involvement. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13822

Department of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.

To investigate the clinical efficacy of surgical treatment for thoracic spinal tuberculosis with kyphosis deformity via posterolateral debridement, fusion, posterior instrumentation and local continuous chemotherapy. A total of 25 patients with thoracic tuberculosis received surgery by posterolateral decompression, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy between June 2009 and October 2011. The clinical outcomes was evaluated using statistical analysis about deformity correction, bone fusion, neurologic status, and the visual analog score (VAS) and erythrocyte sedimentation rate (ESR). Read More

Biomed Pharmacother 2019 Jan 26;109:2014-2021. Epub 2018 Nov 26.

Orthopedics Department, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, 201399, China. Electronic address:

Spinal cord injury (SCI) is a devastating event, leading to the progression of chronic neuropathic pain syndrome. Triggering receptor expressed on myeloid cells 1 (TREM1) is an innate immune receptor expressed on neutrophils and monocytes/macrophages. TREM1 enhances inflammatory response in various models of diseases, but its significance in SCI remains unclear. Read More

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Pavlov Institute of Physiology, Russian Academy of Sciences, Saint-Petersburg, Russia.

Detailed knowledge of the topographic organization and precise access to the spinal cord segments is crucial for the neurosurgical manipulations as well as in vivo neurophysiological investigations of the spinal networks involved in sensorimotor and visceral functions. Because of high individual variability, accurate identification of particular portion of the lumbosacral enlargement is normally possible only during postmortem dissection. Yet, it is often necessary to determine the precise location of spinal segments prior to in vivo investigation, targeting spinal cord manipulations, neurointerface implantations, and neuronal activity recordings. Read More

Orthopade 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedics, Second Hospital of Lanzhou University, 730000, Lanzhou, Gansu Province, China.

Background: To compare clinical and functional outcomes of anterior versus posterior debridement and spinal fixation for surgical treatment of thoracolumbar tuberculosis.

Methods: A computer-based online search of the Cochrane Library, PubMed, EMBase, Wanfang, VIP, and the CNKI database was performed. The methodological quality of included studies was evaluated, and data analyses were performed using RevMan 5. Read More

J Orthop Surg Res 2018 Dec 6;13(1):312. Epub 2018 Dec 6.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Junction tuberculous spondylitis involves the stress transition zone of the spine and has a high risk of progression to kyphosis or paraplegia. Problems still exist with treatment for spinal junction tuberculosis. This study investigated the surgical approach and clinical outcomes of junction spinal tuberculosis. Read More

Int J Infect Dis 2019 Feb 4;79:104-108. Epub 2018 Dec 4.

Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objective: The aim of this study was to investigate the occurrence of paradoxical reaction (PR) in HIV-negative tuberculous meningitis (TBM) patients with spinal involvement, as well as its possible risk factors.

Methods: Fifty TBM patients with spinal involvement were studied retrospectively and divided into a PR group and a non-PR group according to the presence of PR. Their demographic, clinical, radiological, and laboratory data, and status at follow-up were collected and compared. Read More

Int J Surg Case Rep 2019 24;54:55-59. Epub 2018 Nov 24.

Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital - Faculty of Medicine Universitas, Jl. Pangeran Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia. Electronic address:

Introduction: Both gluteal abscess and sacral tuberculosis are rare entities in spinal tuberculosis cases. Even in endemic country, this atypical presentation may be the cause of delayed diagnosis and treatment.

Presentation Of Case: A 51-year-old woman was admitted with painless massive lump on both of her thighs that have been enlarging for the past 6 months. Read More

World Neurosurg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopedic Surgery and Traumatology, Minia University Hospital, El-Minia; and Minia University Spine Unit, Faculty of Medicine, Minia University, Minia University Hospital, El-Minia, Egypt.

Background: Complexity in ventral surgical exposure and presence of scapula and large parascapular musculature during posterior surgery are the main obstacles in operative treatment of upper thoracic spine compressive lesions (UTSCLs), such as trauma, tuberculosis, and neoplasm. Recently, the advantages of combined ventrodorsal surgery could be successfully gained using a 1-stage posterior salvage technique with enough accessibility to all 3 spinal columns. This was a retrospective evaluation of 35 patients with UTSCLs treated by the posterior extensive circumferential decompressive reconstructive (PECDR) procedure. Read More

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, China; Shanghai Guolong hospital, Shanghai, China. Electronic address:

Objective: This retrospective comparative analysis was conducted to assess the effectiveness of affected-vertebrae fixation versus short-segment fixation to treat thoracic spinal tuberculosis.

Methods: This study included 110 patients receiving treatment for thoracic spinal tuberculosis at this hospital between January 2006 and June 2013. All cases involved the use of posterior spinal correction, posterior lateral fusion, internal fixation, anterior decompression, radical debridement, and intervertebral supporting bone grafts. Read More

Musculoskelet Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics, Division of Spine Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, 576-104, Karnataka, India.

Purpose: The present study evaluated the clinical and radiological outcomes in patients with tuberculosis of the thoracic and thoracolumbar spine, treated by an operative technique in which anterior debridement with posterior instrumentation and global fusion was performed through a single-stage posterior approach.

Methods: Ninty-seven patients with spinal tuberculosis, between T1 and L1, in whom anterior debridement, bone grafting, with posterior instrumentation and fusion was performed through a single-stage posterior approach, with a minimum follow-up of 2 years, formed the basis of this study. During each follow-up, neurological recovery was assessed using modified American Spinal Injury Association grading, healing of the disease was assessed by appearance of sclerosis and interbody fusion and the degree of kyphotic deformity was analysed using the modified Konstam's angle. Read More

Zhongguo Gu Shang 2018 Nov;31(11):1012-1016

Department of Orthopaedics, Integrated Chinese and Western Medicine Hospital of Zhejiang Province, Hangzhou 310003, Zhejiang, China.

Objective: To explore the clinical effect of cortical bone trajectory screw technology combined with anterior mini-open debridement and prop graft for lumbar tuberculosis in elderly.

Methods: The clinical data of 22 patients with lumbar tuberculosis treated by cortical bone trajectory screw technology combined with anterior mini-open debridement and prop graft from February 2015 to December 2016 were retrospectively analyzed. There were 13 males and 9 females with an average age of (73. Read More

Zhongguo Gu Shang 2018 Nov;31(11):1005-1011

Department of Surgery, Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China;

Objective: To explore the short-term efficacy of posterior percutaneous screw fixation combined with local percutaneous endoscopic debridement in treating senile spinal tuberculosis.

Methods: The clinical data of 19 senile patients with spinal tuberculosis underwent surgical treatment from January 2015 to September 2016 were retrospectively analyzed. There were 13 males and 6 females, aged from 60 to 73 years old with an average of (66. Read More

Zhongguo Gu Shang 2018 Nov;31(11):998-1004

Department of Orthopaedics, Hospital of Integrated Traditional Chinese and Western Medicine of Zhejiang Province, Hangzhou 310003, Zhejiang, China.

Objective: To investigate the effect of preoperative percutaneous drainage in lumbar tuberculosis with psoas abscess, through compare the clinical efficacy of two different methods.

Methods: Thirty-six patients with lumbar tuberculosis complicated with psoas abscess in corresponding with the inclusion criteria were admitted in Zhejiang Province Traditional Chinese Medicine Hospital from January 2015 to January 2017. The patients were divided into group A and group B according to the different therapeutic methods. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13484

Department of Spine and Jiont Surgery.

The benefits of navigation-assisted technologies are not entirely understood. Therefore, this study aimed to examine the outcomes of patients with lumbar tuberculosis who received computer navigation-assisted minimally invasive direct lateral interbody fusion (DLIF).This was a retrospective study of 33 patients with lumbar tuberculosis who underwent minimally invasive DLIF at the Department of Spine and Orthopedics of Guigang People's Hospital (Guangxi, China) between January 2015 and December 2016. Read More

Int J Paleopathol 2018 Nov 26;24:185-196. Epub 2018 Nov 26.

Centre for GeoGenetics, Natural History Museum, Øster Voldgade 5-7, 1350, Copenhagen, Denmark. Electronic address:

The skeletal remains of the young female (20-24 years) from Grave JP/106, discovered in the Southern Suburb of the Břeclav - Pohansko Stronghold (Early Middle Ages, 9th century-beginning of the 10 century, present day Czech Republic) display several noteworthy pathologies. The first is deformation of the mandible, which was most probably caused by a fracture of the ramus in combination with a subcondylar fracture. The spine of this young woman also exhibits a probable traumatic injury of the cervical spine in combination with a slowly growing structure situated inside the spinal canal, which caused deformation centered upon C7. Read More

World Neurosurg 2019 Feb 19;122:e1472-e1481. Epub 2018 Nov 19.

Department of Orthopaedics, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Objective: To examine effects of percutaneous endoscopic débridement and allograft via the transforaminal approach combined with percutaneous pedicle screw fixation as treatment for single-level thoracic tuberculosis.

Methods: This multicenter retrospective analysis included 75 patients with single-level thoracic tuberculosis who underwent percutaneous endoscopic débridement and allograft via the transforaminal approach combined with percutaneous pedicle screw fixation and were followed for >36 months between January 2012 and December 2014.

Results: Follow-up was 36-48 months (average 41. Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1202-1204

Department of Neurosurgery, Narayana Medical College Hospital, Nellore, Andhra Pradesh, India.

Paraspinal tuberculosis is an uncommon manifestation of extrapulmonary tuberculosis, and in rare cases, these lesions can mimic malignant lesions. We report a case of an elderly man where imaging showed extensive left paraspinal lesion which was mimicking malignant neoplasm. The patient underwent L3-L4 unilateral partial laminotomy, there was grayish, relatively avascular lesion in the left paraspinal region, involving the left psoas muscle and going into the neural foramina, and a subtotal resection of the lesion could be performed. Read More

J Orthop Surg Res 2018 Nov 20;13(1):292. Epub 2018 Nov 20.

Department of Spine Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou City, 350005, Fujian Province, China.

Background: Posterior transfacet approach has been proved to be a safe and effective access to treat thoracic disc herniation. However, the therapeutic effect and safety of modified transfacet approach for treating thoracic spinal tuberculosis (TST) has not been reported in the clinical literature. In this study, the clinical efficacy and safety of a single-stage posterior modified transfacet debridement, posterior instrumentation, and interbody fusion for treating TST were retrospectively evaluated. Read More

J Orthop Surg Res 2018 Nov 19;13(1):290. Epub 2018 Nov 19.

Department of Orthopedics, Hospital of Integrated Traditional Chinese and Western medicine in Zhejiang Province, 208 Huancheng E.Rd, Hangzhou, 310003, Zhejiang Province, People's Republic of China.

Background: Spinal tuberculosis is a frequent cause of psoas abscess (PA), and PA largely negates the efficacy of antituberculosis therapy. This study aimed to investigate the clinical outcome of preoperative percutaneous catheter drainage (PCD) in patients with lumbar spinal tuberculosis and PA.

Methods: Between January 2015 and January 2017, 72 patients with lumbar spinal tuberculosis with PA were assigned to group A (preoperative PCD) and group B (n = 36 per group). Read More

Med J Armed Forces India 2018 Oct 28;74(4):352-357. Epub 2017 Oct 28.

Associate Professor, Dept of Community Medicine & Epidemiologist, Armed Forces Medical College, Pune 411040, India.

Background: Hemoptysis is one of the most alarming condition to both the patients suffering from it and the treating physicians. It is caused due to varied etiologies. One of the emergent and at times life-saving treatment option is by minimally invasive interventional radiological technique of Bronchial Atery Embolization (BAE). Read More

Global Spine J 2018 Oct 12;8(7):698-702. Epub 2018 Apr 12.

Wockhardt Hospital, Mumbai, Maharashtra, India.

Study Design: Retrospective study.

Objectives: Treatment of spinal tuberculosis in the elderly involves consideration of compromised physiology, which often poses a clinical challenge to the surgeons to balance surgical safety versus deteriorating function. Frailty scoring has been reported as an effective tool to predict mortality and morbidity in cardiovascular surgery and recently in hip fractures. Read More

Tunis Med 2018 Jun;96(6):343-347

Introduction: Tuberculosis (TBC) is a major public health problem with high mortality especially in developing countries. It is associated with a higher risk of developing pulmonary and non-pulmonary malignancies including solid and hematologic cancers. Association between TBC and nonpulmonary malignancies is rarely described in the literature. Read More

BMJ Case Rep 2018 Nov 12;2018. Epub 2018 Nov 12.

Consultant Paediatric Infectious Diseases and Immunology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.

A 6-year-old girl presented acutely with worsening frontal headaches. She had a 3-month history of lethargy, reduced appetite, weight loss, cough and intermittent fevers. A chest X-ray showed a left upper lobe consolidation, and a CT head showed multiple enhancing lesions with significant surrounding oedema in both cerebral hemispheres. Read More

BMC Infect Dis 2018 Nov 12;18(1):555. Epub 2018 Nov 12.

Department of Orthopedics Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital, Chang Gung University, No.5, Fu-Shin Street Kweishian, Taoyuan, 333, Taiwan.

Background: Infection after vertebroplasty (VP) is a rare but serious complication. Previous literatures showed most pathogens for infection after VP were bacteria; tuberculosis (TB) induced infection after VP was extremely rare. We reported our treatment experiences of cases with infectious spondylitis after VP, and compared the differences between developed pyogenic and TB spondylitis. Read More

World Neurosurg 2019 Feb 1;122:112-115. Epub 2018 Nov 1.

Department of Neurosurgery Nanoori Hospital, Gangnam, Seoul, Republic of Korea.

Background: Tuberculosis (TB) of the posterior spinal element is an uncommon condition. In a developed country its diagnosis is becoming difficult due to low incidence.

Case Description: A 60-year-old lady presented with low back pain and right leg pain for 6 months. Read More

Open Orthop J 2018 28;12:380-388. Epub 2018 Sep 28.

Department of orthopaedics, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.

Study Design: Prospective randomised control trial.

Purpose: To compare the effectiveness of Directly Observed Treatment and Short Course (DOTS) and Daily Anti Tubercular Therapy (ATT) in spinal tuberculosis with no neurological deficit.

Overview Of Literature: Spinal tuberculosis is rampant in India with a major cause of morbidity and mortality. Read More

J Orthop Surg Res 2018 Oct 26;13(1):269. Epub 2018 Oct 26.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Severe post-tubercular kyphosis with late-onset neurological deficits is difficult to treat, with high risk of neurological complications. This study retrospectively evaluates the efficacy and safety of posterior vertebral column resection (PVCR) for treating severe post-tubercular kyphosis with late-onset neurological deficits.

Methods: From January 2012 to December 2015, 13 patients with severe post-tubercular kyphosis underwent PVCR. Read More

J Orthop Surg (Hong Kong) 2018 May-Aug;26(3):2309499018806684

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Purpose:: The study aimed to evaluate the efficiency of the posterior-only approach using shaped titanium mesh cage for surgical treatment of spinal tuberculosis (TB) in children.

Methods:: Between January 2011 and July 2013, 22 children with a single motion spinal segment involved, including 10 with thoracic, 4 with thoracolumbar, and 8 with lumbar, were enrolled in the study. The patients were treated by the posterior-only approach using the shaped titanium mesh cages. Read More

Glob Pediatr Health 2018 15;5:2333794X18805614. Epub 2018 Oct 15.

KK Women's and Children's Hospital, Singapore, Singapore.

In this article, we report a case of tuberculosis spondylodiscitis in a 2-year-old child. Imaging of her spine showed a paraspinal abscess. The diagnosis of spinal tuberculosis remains difficult, and we discuss its salient features and current management within the pediatric population. Read More

J Assoc Physicians India 2018 Apr;66(4):72-74

Senior Resident Neurosurgery, N.S.C.B. Medical College, Jabalpur, Madhya Pradesh.

Tuberculosis of the central nervous system (CNS) is well known. CNS involvement can occur in the form of tubercular meningitis (TBM), tuberculous vasculitis, tuberculoma and rarely brain abscess. Tubercular granulomas generally solitary and occur in the brain but they may be multiple and involve other areas such as spinal cord, epidural space and subdural space also. Read More