5,697 results match your criteria Pott Disease Tuberculous Spondylitis


Granulomatous spondylodiscitis: A case series with focus on histopathological features.

J Spinal Cord Med 2019 Apr 23:1-6. Epub 2019 Apr 23.

d Service de Radiologie , Institut Mohamed Kassab d'orthopédie , Ksar Said , Tunis , Tunisie.

Objective: To report a series of Granulomatous Spondylodiscitis (GS) with focus on the histopathological features of the different forms of GS.

Design: Case series.

Setting: Pathology department of Charles Nicolle's Hospital of Tunisia Participants: This study included 57 patients diagnosed with GS. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607054DOI Listing

One-stage Surgical Treatment for Consecutive Multi-segment Thoracic Spinal Tuberculosis with Kyphosis by Posterior-only Debridement, Interbody Fusion and Instrumentation.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Spinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China. Electronic address:

Objective: To evaluate the clinical efficacy and feasibility of one-stage surgical treatment for consecutive multi-segment thoracic spinal tuberculosis with kyphosis by posterior-only debridement, interbody fusion and instrumentation.

Methods: Sixty-two patients who underwent posterior debridement, interbody fusion and instrumentation were reviewed for radiographic fusion, region kyphosis, neurological status and clinical outcomes. Thoracic Cobb's angle and Frankel grading system were employed to assess kyphosis and neurological improvements, respectively. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.122DOI Listing

Endovascular treatment of a ruptured thoracic aortic pseudoaneurysm secondary to Pott disease during a spine surgery: A case report and a literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15306

Department of Orthopedic Surgery.

Rationale: The coexistence of a tuberculous aortic pseudoaneurysm and Pott disease in patients with a history of tuberculosis (TB) is relatively rare, and the treatment strategies remain still controversial.

Patient Concerns: A 57-year-old female patient with a history of primary pulmonary TB presented with symptoms of breathlessness, chest pain, weight loss, and fever. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a thoracic aortic pseudoaneurysm secondary to Pott disease at T11/12 level. Read More

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http://dx.doi.org/10.1097/MD.0000000000015306DOI Listing

Concurrent Spinal Epidural Tubercular and Pyogenic Abscess of Cervical Spine without Bony Involvement.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):374-378

Department of Neurosurgery, L.T.M.G. Hospital, Mumbai, Maharashtra, India.

Spinal epidural abscess (SEA) presents with vertebral body involvement. SEA is mostly pyogenic in developed countries, but in developing countries, tuberculosis is more common cause. Young female presented with fever, neck, and right upper limb pain for 1 month followed by acute onset weakness in the right upper limb. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_318_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454951PMC

Standalone Instrumented Posterior Approach Used as Universal Approach for Tuberculosis Spondylodiscitis.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):225-233

Department of Neurosurgery, AIIMS, Bhubaneswar, Odisha, India.

Background: Surgical management of spinal tuberculosis (TB) has been classically the anterior, then combined, and of late increasingly by the posterior approach. The posterior approach has been successful in early disease. There has been a paradigm shift and inquisitive to explore this approach in the more advanced and even long-segment disease. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_294_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454971PMC

Efficacy of local wound infiltration analgesia with ropivacaine and dexmedetomidine in tubercular spine surgery - A pilot randomised double-blind controlled trial.

Indian J Anaesth 2019 Mar;63(3):182-187

Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Background And Aims: Regional analgesic techniques are difficult to use in tubercular spine patients due to distorted spinal anatomy and presence of infection. This study was conducted with the aim to evaluate analgesic efficacy of local wound infiltration before wound closure in tubercular spine patients.

Methods: This pilot randomised double-blind controlled study was conducted in 32 American Society of Anesthesiologists I-III patients, age ≥15 years, undergoing elective surgery for spinal tuberculosis. Read More

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http://dx.doi.org/10.4103/ija.IJA_780_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423940PMC
March 2019
1 Read

A case report of intraventricular and intrathecal tigecycline infusions for an extensively drug-resistant intracranial Acinetobacter baumannii infection.

Medicine (Baltimore) 2019 Apr;98(15):e15139

Department of Infectious Disease.

Rationale: The treatment of intracranial Acinetobacter baumannii infections is made difficult by multidrug-resistance poor drug penetration through the blood-brain barrier (BBB). Although tigecycline appears to be effective against A baumannii, it is only administered intravenously because it does not readily cross the BBB. The addition of intraventricular (IVT) or intrathecal infusions of tigecycline could revolutionize clinical therapy for intracranial A baumannii infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000015139DOI Listing
April 2019
1 Read

[Comparison of short-term effectiveness of structural and non-structural bone graft fusion in treatment of single segment thoracic tuberculosis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):403-409

Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.

Objective: To compare the short-term effectiveness of one-stage posterior debridement with non-structural bone graft and structural bone graft in the treatment of single segment thoracic tuberculosis.

Methods: The data of 61 patients with single segment thoracic tuberculosis, who were treated by one-stage posterior debridement, bone graft fusion, and internal fixation between June 2011 and August 2015, was retrospectively analyzed. All of them, 26 cases were treated with structural bone graft (group A) and 35 cases with non-structural bone graft (group B). Read More

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http://dx.doi.org/10.7507/1002-1892.201808095DOI Listing
April 2019
1 Read

Cervical spondylodiscitis mimicking Pott's disease: a case report.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):1-5

Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy.

Introduction: The leading cause of pyogenic vertebral osteomyelitis is Staphylococcus aureus, and its incidence is rising, particularly in the elderly. We report an unusual case of cervical spondylodiscitis and epidural abscess mimicking Pott's disease.

Case Report: A 67-year-old man was admitted to our institution with a 15-day history of neck pain radiating to the head, shoulders and left arm that was associated with weakness and paresthesia. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17467DOI Listing
April 2019
1 Read

One stage posterior debridement, non-structural bone graft in the surgical treatment of single segment thoracic tuberculosis: A retrospective single-center cohort study.

Int J Surg 2019 Apr 9;65:134-139. Epub 2019 Apr 9.

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Objective: To compare the clinical efficacy of non-structural with structural bone graft in the surgical treatment of single segment thoracic tuberculosis after one stage posterior debridement.

Methods: 61 patients with single segment thoracic tuberculosis treated by one stage posterior debridement, bone graft fusion and internal fixation were retrospectively analyzed. Among them, 35 cases were admitted from 2015 to 2017 in the non-structural bone graft group and 26 cases were admitted from 2011 to 2015 in the structural bone graft group. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.002DOI Listing
April 2019
1 Read

Evaluation of clinical outcomes of one-stage anterior and posterior surgical treatment for atlantoaxial tuberculosis complicated with neurological damage.

BMC Musculoskelet Disord 2019 Apr 6;20(1):148. Epub 2019 Apr 6.

Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University College of Medicine, No. 76 Nanguo Road, Xi'an, 710054, Shaanxi, China.

Background: Surgical treatment is mainly used for atlantoaxial tuberculosis with neurological damage. However, the anatomic structure around the atlantoaxial joint is complex, and the position of vertebral body is deep, which increases the difficulty of the operation and it is challenging for the surgeon to develop surgical strategy. The purpose of this study was to evaluate the clinical outcomes of one-stage combined anterior and posterior surgical treatment approach for atlantoaxial tuberculosis with neurological impairment. Read More

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http://dx.doi.org/10.1186/s12891-019-2539-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451780PMC
April 2019
3 Reads

3D printing assisted cervical anterior bilateral pedicle screws fixation of artificial vertebral body for the cervical tuberculosis: a case report.

World Neurosurg 2019 Apr 1. Epub 2019 Apr 1.

Department of Orthopedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address:

Background: Cervical tuberculosis (CTB) only accounts for 4.2%-12% of the total spinal tuberculosis. Although anti-tuberculosis drugs are the cornerstone of the treatment for cervical tuberculosis, they are ineffective against the symptoms of the existing spinal deformities and spinal cord compression, which often appeal to surgical intervention. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.238DOI Listing
April 2019
4 Reads

Clinical Characteristics of 1378 Inpatients with Spinal Tuberculosis in General Hospitals in South-Central China.

Biomed Res Int 2019 3;2019:9765253. Epub 2019 Mar 3.

Department of Spine Surgery, Xiangya Hospital, Central South University, 87#Xiangya Road, Changsha 410008, Hunan, China.

In this retrospective study, charts of inpatients with spinal tuberculosis (STB) treated in large-scale general hospitals in Changsha, Hunan, China, between 2007 and 2016 were reviewed to investigate their clinical characteristics. Demographic, epidemiological and clinical features, imaging findings, treatment methods, and prognosis were summarized and analyzed. There were 1378 patients, 805 males and 573 females, with a mean age of 43. Read More

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http://dx.doi.org/10.1155/2019/9765253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421015PMC
March 2019
2 Reads

miRNA-155 expression and role in pathogenesis in spinal tuberculosis-induced intervertebral disc destruction.

Exp Ther Med 2019 Apr 26;17(4):3239-3246. Epub 2019 Feb 26.

Trauma Center, Guangxi Liuzhou Workers Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545000, P.R. China.

The current study aimed to investigate microRNA-155 (miR-155) expression in spinal tuberculosis-induced intervertebral disc destruction and its regulatory role in disease pathogenesis. A total of 26 patients with intervertebral disc destruction induced by spinal tuberculosis and 31 healthy individuals were included. Reverse transcription-quantitative polymerase chain reactions, western blot analysis and ELISA were performed to detect mRNA and protein expression levels. Read More

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http://dx.doi.org/10.3892/etm.2019.7313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434382PMC
April 2019
1 Read

Spinal Anesthesia for Renal Transplantation in Lung Resected Patient: A Case Report.

Tanaffos 2018 Mar;17(3):207-210

Department of Anesthesiology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Renal transplantation is among the definitive therapies for treatment of patients with "End-Stage Renal Disease" (ESRD). Proper anesthesia should be considered in patients who undergo renal transplantation. On the other hand, anesthesia in patients with single lung is an ever challenging issue. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428382PMC
March 2018
1 Read

Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis.

Neurol Res 2019 Mar;41(3):199-203

a Department of Neurology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.

Objective To investigate the diagnostic value of electroencephalogram (EEG) complexity in patients with neurosyphilis by comparing the changes of electroencephalogram Lempel-Ziv complexity (EEG-LZC) before and after anti-syphilis treatment. Methods The EEG complexity of neurosyphilis patients diagnosed in our hospital from July in 2015 to June in 2017 was analyzed and compared with other diagnostic results such as serology examination and cerebrospinal fluid examination. Results A total of 27 patients were diagnosed, including 19 males and 8 females, of which 6 were mesenchymal(cerebrospinal membrane and meningeal vascular), 16 were parenchymal(paralytic dementia, spinal cord tuberculosis and optic neuropathy), and 5 were asymptomatic. Read More

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http://dx.doi.org/10.1080/01616412.2018.1520438DOI Listing
March 2019
1 Read

Minimum 5-year follow-up outcomes for Comparison between Titanium mesh cage and allogeneic bone graft to Reconstruct Anterior Column through Posterior Approach for the Surgical treatment of Thoracolumbar Spinal Tuberculosis with Kyphosis.

World Neurosurg 2019 Mar 22. Epub 2019 Mar 22.

Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital of Central South University, ChangSha, China.

Objective: We aimed to compare the clinical efficacy of a titanium mesh cage and an allogeneic bone graft to reconstruct the anterior column through a posterior approach for the surgical management of patients with thoracolumbar spinal tuberculosis with kyphosis.

Methods: From January 2011 to March 2013, 57 patients with single- or two-segment thoracolumbar spinal tuberculosis with kyphosis were treated by debridement, interbody graft, posterior instrumentation, and fusion via a posterior-only procedure. The 24 patients in group A were treated with an allogeneic bone graft to reconstruct the anterior column, whereas the 33 patients in group B were treated with a titanium mesh cage. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.139DOI Listing
March 2019
1 Read

The Spectrum of Clinical and Urodynamic Findings in Patients with Spinal Tuberculosis Exhibiting Lower Urinary Tract Symptoms, before and after Spinal Surgical Intervention with Antitubercular Treatment: A Prospective Study.

Asian Spine J 2019 Mar 26. Epub 2019 Mar 26.

Department of Orthopedics, All India Institute Of Medical Sciences, New Delhi, India.

Study Design: Observational study.

Purpose: This study aims to assess the clinical and urodynamic parameters in patients with spinal tuberculosis (TB) exhibiting lower urinary tract symptoms (LUTS) at the time of presentation and after spinal surgical intervention.

Overview Of Literature: Variable urodynamic findings in patients with spinal TB. Read More

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http://dx.doi.org/10.31616/asj.2018.0217DOI Listing
March 2019
1 Read

Challenges in the Diagnosis and Management of Spinal Tuberculosis: Case Series.

Cureus 2019 Jan 8;11(1):e3855. Epub 2019 Jan 8.

Orthopaedics, Syracuse Veterans Affairs Hospital, Syracuse, USA.

Though uncommon in developed countries, spinal tuberculosis must still be considered in patients with a suspicious clinical history, to avoid delays in treatment. This case series highlights the special considerations that need to be taken into account while tackling the diagnostic and therapeutic challenges associated with this disease. We present two interesting cases of spinal tuberculosis. Read More

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http://dx.doi.org/10.7759/cureus.3855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411342PMC
January 2019
1 Read

Comparison of anterior, posterior, and anterior combined with posterior surgical treatment of thoracic and lumbar spinal tuberculosis: a systematic review.

J Int Med Res 2019 Mar 17:300060519830827. Epub 2019 Mar 17.

2 Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: This study was performed to compare different surgical approaches in the treatment of spinal tuberculosis.

Methods: We conducted a literature search to identify and analyze papers published from January 1966 to April 2018 relevant to comparison of the anterior, posterior, and anterior combined with posterior approaches in the treatment of spinal tuberculosis of the thoracic and lumbar regions.

Results: Twenty-five studies involving 2295 patients were identified in this systematic review. Read More

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http://dx.doi.org/10.1177/0300060519830827DOI Listing
March 2019
1 Read

[Application of one-stage posterior surgery via unilateral musculussacrospinalis iliac flap approach in treatment of lumbosacral tuberculosis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 03;33(3):296-301

Department of Orthopedics, Guizhou Provincial People's Hospital, Guiyang Guizhou, 550002, P.R.China.

Objective: To evaluate the safety and effectiveness of one-stage posterior surgery via unilateral musculussacrospinalis iliac flap approach in treatment of lumbosacral tuberculosis.

Methods: Between August 2011 and October 2014, 13 patients with lumbosacral tuberculosis were treated by one-stage posterior reserved posterior ligament complex, lesion debridement, bone graft fusion, and internal fixation via unilateral musculussacrospinalis iliac flap approach. There were 8 males and 5 females, aged from 22 to 57 years, with an average age of 35 years. Read More

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http://dx.doi.org/10.7507/1002-1892.201809090DOI Listing
March 2019
2 Reads

[Effect of surgical timing on effectiveness of thoracic spinal tuberculosis with myelopathy].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 03;33(3):273-279

Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.

Objective: To explore the feasibility of posterior debridement, decompression, bone grafting, and fixation in treatment of thoracic spinal tuberculosis with myelopathy, and investigate the effects of surgical timing on postoperative outcomes.

Methods: The clinical data of 26 patients with thoracic spinal tuberculosis with myelopathy between August 2012 and October 2015 was retrospectively analyzed. All patients underwent posterior unilateral transpedicular debridement, decompression, bone grafting, and fixation and were divided into two groups according to surgical timing. Read More

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http://dx.doi.org/10.7507/1002-1892.201808071DOI Listing
March 2019
1 Read

The outcome of intervertebral surgery in the treatment of lumbar tuberculosis in children: A case series and long-term follow-up.

Medicine (Baltimore) 2019 Mar;98(10):e14815

Ningxia Medical University.

During the operation of treating lumbar tuberculosis in children, a long-segment or short-segment fixation, and fusion method were usually applied, which would adversely affect the function of normal motion unit. And so, we have been focusing on how we can shorten the range of fixation and fusion using intervertebral surgery. The objective of this retrospective study is to investigate the clinical outcome of intervertebral surgery, in the treatment of lumbar tuberculosis in children. Read More

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http://dx.doi.org/10.1097/MD.0000000000014815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417510PMC
March 2019
1 Read
5.723 Impact Factor

Comparison of mid-term outcomes of posterior or postero-anterior approach using different bone grafting in children with lumbar tuberculosis.

Medicine (Baltimore) 2019 Mar;98(10):e14760

Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, China.

The anterior and middle columns instead of the posterior column of spine are usually destroyed by tuberculosis which could aggravate the kyphosis accompanying the growth imbalance of spine in children. The surgical method needs to be selected cautiously for effective treatment. To our knowledge, few studies have evaluated mid-term outcomes of 2 surgeries (posterior-only approach and combined posterior and anterior approaches) with allograft or shaped titanium mesh cages for the treatment of lumbar tuberculosis in children. Read More

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http://dx.doi.org/10.1097/MD.0000000000014760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417493PMC
March 2019
1 Read

Safety and efficacy of transcatheter embolization in patients with massive hemoptysis due to intercostal pulmonary venous shunts.

Radiol Med 2019 Mar 9. Epub 2019 Mar 9.

First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.

Purpose: Bronchial hemoptysis induced by intercostal pulmonary venous shunt (IPVS) is clinically rare. Pulmonary lesions on pleural surface may facilitate opening of vascular network. This retrospective study investigated safety and efficacy of embolization agents with small-particle embolization treating patients with massive hemoptysis due to IPVS. Read More

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http://dx.doi.org/10.1007/s11547-019-01020-0DOI Listing
March 2019
1 Read

Single-stage posterior debridement, decompression and transpedicular screw fixation for the treatment of thoracolumbar junction (T12-L1) tuberculosis with associated neurological deficit: a multicentre retrospective study.

BMC Musculoskelet Disord 2019 Mar 4;20(1):95. Epub 2019 Mar 4.

Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.

Background: A multicentre retrospective study was conducted to evaluate the safety and efficacy of single-stage posterior debridement, decompression and transpedicular screw fixation for the treatment of thoracolumbar junction (T12-L1) tuberculosis in patients with associated neurological deficit.

Methods: Thoracolumbar junction (T12-L1) tuberculosis patients (n = 69) with neurological deficit who underwent single-stage posterior debridement, decompression and transpedicular screw fixation from January 2005 to January 2015 were included in the study. Antituberculosis therapy was performed both before and after surgery. Read More

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http://dx.doi.org/10.1186/s12891-019-2466-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399925PMC
March 2019
3 Reads

Multiple spinal intramedullary PNETs mimicking acute myelitis: a case report.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

Department of Radiology, Shaanxi Provincial People's Hospital. Electronic address:

Background: Primitive neuroectodermal tumors (PNETs) are rare malignant neoplasms in the spinal cord that comprise undifferentiated or poorly differentiated neural crest cells. PNETs imaging findings lack specificity, making diagnosis difficult.

Case Description: A 16-year-old man presented with progressive weakness and numbness of the lower extremities for 1 month, which occurred after a cold. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.108DOI Listing
March 2019
1 Read

Percutaneous Pedicle Screw Fixation Alone Versus Debridement and Fusion Surgery for the Treatment of Early Spinal Tuberculosis: A Retrospective Cohort Study.

Med Sci Monit 2019 Feb 27;25:1549-1557. Epub 2019 Feb 27.

Department of Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

BACKGROUND Advances in diagnostic imaging techniques make it possible to detect tuberculosis (TB) lesions earlier, when only bone destruction or inflammatory infiltration is demonstrated. These techniques provide doctors with more opportunities to treat TB in the early stages of the disease. Traditional aggressive debridement surgery increases the risk of surgical complications. Read More

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http://dx.doi.org/10.12659/MSM.912538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402273PMC
February 2019
3 Reads

Intradural Abscess of the in an Otherwise Healthy Patient.

Case Rep Surg 2019 22;2019:4860420. Epub 2019 Jan 22.

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Abscesses involving the spine are usually located in the epidural space. In rare circumstances, intradural spinal abscesses can occur, typically in the setting of tuberculosis or other predisposing systemic conditions. In this illustrated case report, we discuss the imaging and intraoperative findings of an otherwise healthy patient with an intradural abscess of the caused by . Read More

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http://dx.doi.org/10.1155/2019/4860420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362506PMC
January 2019
1 Read

Clinical study of spinal tuberculosis presenting with neuro-deficits in Western India.

Indian J Tuberc 2019 Jan 13;66(1):81-86. Epub 2018 Apr 13.

Postgraduate Student, Department of Medicine, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India.

Background/objectives: Spinal tuberculosis (TB) is a destructive extra-pulmonary disease manifestation of Mycobacterium tuberculosis infection. It is responsible for many cases of paraparesis and quadriparesis in developing countries where patients seek treatment late. The aim of this study was to understand and analyze the clinical and radiological profile of patients with spinal TB and correlate it with the anatomical site affected by it. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00195707173034
Publisher Site
http://dx.doi.org/10.1016/j.ijtb.2018.04.009DOI Listing
January 2019
6 Reads

Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India.

Indian J Tuberc 2019 Jan 16;66(1):49-57. Epub 2017 Jun 16.

Department of Respiratory Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

Objectives: Central nervous system (CNS) is an important site for extrapulmonary tuberculosis. The present study evaluated the spectrum of CNS tuberculosis in a high tuberculosis endemic region.

Methods: The study included 306 cases of CNS tuberculosis. Read More

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http://dx.doi.org/10.1016/j.ijtb.2017.05.011DOI Listing
January 2019
1 Read

[Epidemiological and Etiological Characteristics of Myelopathies in the Neurology Department of the University Hospital Center of Cocody, Abidjan (Ivory Coast)].

Bull Soc Pathol Exot 2018 ;111(4):201-204

Service de neurologie, CHU de Cocody, BP V 13 Abidjan, Côte-d'Ivoire.

The term myelopathy defines a suffering of the spinal cord whatever the etiologies. They often represent real therapeutic emergencies and are burdened by serious functional sequelae. The aim of this work was to describe the epidemiological, clinical, and etiological aspects of all myelopathies. Read More

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http://dx.doi.org/10.3166/bspe-2018-0043DOI Listing
January 2018
1 Read

[A Rare Localization of Tuberculosis: Talus Tuberculosis (Observation of a Female Patient from Marrakech Region, Morocco)].

Bull Soc Pathol Exot 2018 ;111(2):74-76

Service de pneumologie, hôpital militaire Avicenne, avenue Al-Mouqaouama, Marrakech 40000, Maroc.

Osteoarticular localization is rare and dominated by spinal disease. The talus localization of tuberculosis is rarely described in the literature; it can be secondary of direct inoculation or results from hematogenous dissemination, most of the time from lung tuberculosis. Its diagnosis is difficult; the imaging is very suggestive, but the confirmation is bacteriological and/or histological. Read More

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http://dx.doi.org/10.3166/bspe-2018-0022DOI Listing
January 2018

Tetraplegia associated with post-operative syringomyelia in spinal tuberculosis: a result of an epidural compartment syndrome?

Spinal Cord Ser Cases 2019 12;5:18. Epub 2019 Feb 12.

Department of Orthopaedics, Max Smart Super Specialty Hospital, New Delhi, India.

Introduction: The commonly recognized causes of post-operative neurological deterioration in spinal tuberculosis are inadequate decompression, damage to vascular supply of the spinal cord, and multi-drug resistant organisms. There are no known cases of syringomyelia developing after surgical decompression of spinal tuberculosis.

Case Presentation: A teenage girl presented with rapid onset quadriparesis secondary to a tubercular epidural abscess extending from C4-T8. Read More

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http://www.nature.com/articles/s41394-019-0159-y
Publisher Site
http://dx.doi.org/10.1038/s41394-019-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372701PMC
February 2019
4 Reads

The role of Technetium-99m-Ethambutol scintigraphy in the management of spinal tuberculosis.

World J Nucl Med 2019 Jan-Mar;18(1):13-17

Departement of Nuclear Medicine and Molecular Imaging, Faculty of Medicine, Dr. Hasan Sadikin Hospital, Padjadjaran University, Bandung, Indonesia.

Spines is a common site of extrapulmonary Mycobacterium tuberculosis infection (MTI). Spine destruction due to MTI can mimic other etiologies. Treatment of choice for spinal tuberculosis (STB) is anti-TB drugs while surgery could be needed in other causes. Read More

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http://dx.doi.org/10.4103/1450-1147.250325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357715PMC
February 2019
1 Read

COMPLICATED LUMBAR TUBERCULOUS SPONDYLODISCITIS IN DISSEMINATED TUBERCULOSIS, TREATED USING A NON-CONVENTIONAL ANTERIOR SUPPORT SYSTEM FOR HYDROSTATIC DISTRACTION: A CASE REPORT.

Acta Ortop Bras 2018 ;26(6):401-405

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (IOT-HCFMUSP), Instituto de Ortopedia e Traumatología, Spine Surgery Division, São Paulo, SP, Brazil.

Objective: To describe a case of disseminated tuberculosis affecting the lumbar spine that was treated using a non-conventional anterior support system.

Background: Tuberculous spondylodiscitis is the most common and most severe form of extrapulmonary tuberculosis. Although antibiotic therapy is the most frequently used treatment, surgery is necessary in cases of neurological deficit, spinal instability, significant deformity, severe sepsis, paravertebral and epidural abscesses or in cases wherein clinical treatment has failed. Read More

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http://dx.doi.org/10.1590/1413-785220182606178095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362687PMC
January 2018
1 Read

A novel fixation technique using anterior C1 screw in a pediatric solitary cervical spinal juvenile xanthogranuloma.

Eur Spine J 2019 Feb 15. Epub 2019 Feb 15.

Department of Histopathology, PGIMER, Chandigarh, India.

Purpose: Juvenile xanthogranuloma (JXG) presenting as solitary vertebral body lesion is infrequently seen and usually limited to one or two levels. We report a case of an isolated JXG with extensive cervical spinal (bony and extradural) involvement in a 6-year-old child. There was a diagnostic dilemma as the radiologic and intraoperative picture resembled tuberculosis. Read More

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http://link.springer.com/10.1007/s00586-019-05915-4
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http://dx.doi.org/10.1007/s00586-019-05915-4DOI Listing
February 2019
8 Reads

Surveillance of tuberculosis (TB) cases attributable to relapse or reinfection in London, 2002-2015.

PLoS One 2019 15;14(2):e0211972. Epub 2019 Feb 15.

Field Service, National Infection Service, Public Health England, London, United Kingdom.

Recurrence of TB in an individual can occur due to relapse of the same strain or reinfection by a different strain. The contribution of reinfection and relapse to TB incidence, and the factors associated with each are unknown. We aimed to quantify and describe cases attributable to relapse or reinfection, and identify associated risk factors in order to reduce recurrence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211972PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377187PMC
February 2019
2 Reads

Value of CT-guided Core Needle Biopsy in Diagnosing Spinal Lesions: A Comparison Study.

Orthop Surg 2019 Feb 14;11(1):60-65. Epub 2019 Feb 14.

Department of Orthopaedics, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: A retrospective study was designed to evaluate the effectiveness of CT-guided core needle biopsy in diagnosing spinal lesions through comparison with C-arm guidance.

Methods: From April 2013 to July 2017, a total of 188 patients, who suffered from spinal lesions or had malignant tumor history with a new spinal fracture, were included in this study. There were 96 men and 92 women, with an average of 57. Read More

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http://dx.doi.org/10.1111/os.12418DOI Listing
February 2019
1 Read

Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337963PMC
February 2019
1 Read

[Clinical utility of HIV viral load assessment in cerebral spinal fluid, a case report].

Rev Chilena Infectol 2018 ;35(5):601-605

Servicio de Medicina Interna, Unidad de Infectología, Chile.

Detection of virus in cerebrospinal fluid (CSF) in HIV-infected patients with HIV viral load (VL) undetectable in plasma has been termed viral escape. These leaks may be asymptomatic from a neurological point of view, similar to plasma blips, or associated with neurological disease, with discordant VL between plasma and CSF, and may be evidence of a compartmentalization of the virus and the possibility of identifying quasispecies with mutations that confer resistance to ART. We present the case of a man with AIDS and disseminated tuberculosis who presented neurological symptomatology evidenced by headache and convulsive syndrome, who presented a discordance between plasma and CSF HIV VL; the genotypic test of the virus, obtained by lumbar puncture, identified new mutations that determined a change in ART with subsequent satisfactory evolution. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500601DOI Listing
January 2018
1 Read

Challenges in diagnosis of spinal epidural abscess: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14196

Department of Orthopedics.

Rationale: Spinal epidural abscess (SEA) is a rare condition that shows a high prevalence in immunocompromised patients. The clinical presentation of SEA includes the "classic triad" of pain, fever, and neurological dysfunction. However, these nonspecific features can lead to a high rate of misdiagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380696PMC
February 2019
2 Reads

Posterior versus Anterior Approach Surgery for Thoracolumbar Spinal Tuberculosis.

J Coll Physicians Surg Pak 2019 Feb;29(2):187-188

Department of Orthopedics, The Third People's Hospital of Shenzhen City, 518112, China.

The aim of this study was to compare clinical effect of posterior approach and anterior approach surgery for patients with thoracolumbar spinal tuberculosis. It was a descriptive, analytical study carried out at the Third People's Hospital of Shenzhen City, China, from March 2012 to March 2015. A total of 84 patients with thoracolumbar spinal tuberculosis were randomly divided into group A and group B, each group having 42 patients. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.02.187DOI Listing
February 2019
2 Reads

Spinal Tuberculosis: A Literature Review.

JBJS Rev 2019 Jan;7(1):e9

Department of Respiratory Medicine and Infectious Diseases (V.L.C.W.) and Spinal Department (A.S.M.), Royal London Hospital, London, England.

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http://dx.doi.org/10.2106/JBJS.RVW.18.00035DOI Listing
January 2019
3 Reads

Can a posterior approach effectively heal thoracic and lumbar tuberculosis? Microbiology outcomes of the operative area.

J Orthop Surg Res 2019 Jan 22;14(1):24. Epub 2019 Jan 22.

Department of Orthopedics, Southwest Hospital, The Army (Third Military) Medical University, GaoTanYan 29, Chongqing, 400038, China.

Background: There was a controversy about surgery approach of thoracic and lumbar tuberculosis (TB) treatment. The aim of this study was to compare the microbiology outcomes of the drainage liquid and the clinical outcomes of a posterior and anterior approach in the treatment of thoracic and lumbar TB.

Materials And Methods: A total of 105 patients were enrolled in this prospective study from February 2011 to September 2015. Read More

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http://dx.doi.org/10.1186/s13018-019-1063-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341735PMC
January 2019
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'Need of the Hour': Early Diagnosis and Management of Multidrug Resistant Tuberculosis of the Spine: An Analysis of 30 Patients from a "High Multidrug Resistant Tuberculosis Burden" Country.

Asian Spine J 2019 Apr 24;13(2):265-271. Epub 2019 Jan 24.

Spinal Disorder Surgery Unit, Department of Orthopaedics, Christian Medical College and Hospital, Vellore, India.

Study Design: Retrospective study.

Purpose: To report the prevalence of patients with multidrug-resistant (MDR) tubercular spondylodiscitis and their outcomes. Additionally, to assess the role of Xpert MTB/RIF assay in early detection of MDR tuberculosis. Read More

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http://dx.doi.org/10.31616/asj.2018.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454281PMC
April 2019
3 Reads

Does Preserving or Restoring Lumbar Lordosis Have an Impact on Functional Outcomes in Tuberculosis of the Lumbosacral Region?

Spine Deform 2019 03;7(2):356-363

Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore 641043, India.

Study Design: Single-center retrospective cohort analysis.

Objectives: To analyze the impact of loss of global lumbar lordosis (GLL) on functional outcomes in tuberculosis of the lumbar and lumbosacral spine and to define strategies to restore or preserve the physiological lumbar lordosis.

Summary Of Background Data: In tuberculosis of lumbosacral spine, loss of lumbar lordosis (LL) leads to altered lumbosacral biomechanics. Read More

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http://dx.doi.org/10.1016/j.jspd.2018.08.005DOI Listing
March 2019
2 Reads

A paleopathological approach to early human adaptation for wet-rice agriculture: The first case of Neolithic spinal tuberculosis at the Yangtze River Delta of China.

Int J Paleopathol 2019 Mar 16;24:236-244. Epub 2019 Jan 16.

Department of Archaeology, Shanghai Museum, China.

The earliest evidence of human tuberculosis can be traced to at least the early dynastic periods, when full-scaled wet-rice agriculture began or entered its early developmental stages, in circum-China countries (Japan, Korea, and Thailand). Early studies indicated that the initial spread of tuberculosis coincided with the development of wet-rice agriculture. It has been proposed that the adaptation to agriculture changed human social/living environments, coincidentally favoring survival and spread of pathogenic Mycobacterial strains that cause tuberculosis. Read More

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http://dx.doi.org/10.1016/j.ijpp.2019.01.002DOI Listing
March 2019
5 Reads

Clinical-Morphological Aspects in Spinal Tuberculosis.

Curr Health Sci J 2018 Jul-Sep;44(3):250-260. Epub 2018 Jul 15.

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Osteoarticular tuberculosis (OATB) Aim: The authors made a clinical morphological assessment of tissue samples from patients admitted in Surgical Departments of the Emergency County Hospital of Craiova, Romania, between 1990 and 2015, proved as presenting tuberculous lesions of the spine in the Department of Pathology of the same Hospital.

Materials And Methods: The studied material consisted of bone, joint and sometimes muscle tissue fragments resulted from biopsies or surgical excisions from 7 cases coming out of 54 patients investigated in the above-mentioned period of time, where the established histological diagnosis was tuberculosis (TB). For diagnostic confirmation, Ziehl-Neelsen staining has been used as a rule but, in some cases, immunohistochemistry was also used. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311224PMC
July 2018
2 Reads