Search Our Scientific Publications & Authors

BMC Cancer 2018 Dec 4;18(1):1209. Epub 2018 Dec 4.

Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Hodgkin's lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor and a putative target for novel immunotherapies. To study patterns of TIGIT expression in the T cell background surrounding malignant cells including Hodgkin cells, Reed-Sternberg cells and histiocytic cells, a microenvironment (ME) tissue microarray (TMA) was constructed from tissue punches measuring 2 mm in diameter obtained from formalin-fixed tissue samples of Hodgkin's lymphoma lymph nodes (n = 40) and normal human tonsil (n = 2). Read More

Nat Commun 2018 Dec 3;9(1):5141. Epub 2018 Dec 3.

Intramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Read More

Biomolecules 2018 Nov 19;8(4). Epub 2018 Nov 19.

Department of Internal Medicine II, Ulm University, Albert-Einstein-Allee 23, D-89081 Ulm, Germany.

Patients with inherited dilated cardiomyopathy (DCM) often suffer from severe heart failure based on impaired cardiac contractility leading to increased morbidity and mortality. Integrin-linked kinase (ILK) as a part of the cardiac mechanical stretch sensor was found to be an essential genetic regulator of cardiac contractility. Integrin-linked kinase localizes to z-disks and costameres in vertebrate hearts and regulates the activity of the signaling molecule protein kinase B (PKB/Akt) by controlling its phosphorylation. Read More

Biomolecules 2018 Nov 19;8(4). Epub 2018 Nov 19.

Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany.

: Atrial fibrillation is common in patients with mitral regurgitation (MR) and has a negative impact on the clinical outcome of patients with valvular heart disease. We aimed to evaluate the impact of pre-procedural atrial fibrillation on the long-term clinical outcomes of patients with MR undergoing transcatheter mitral valve repair by MitraClip implantation. : We analysed 355 consecutive patients with and without atrial fibrillation with symptomatic, severe MR and inoperability or high surgical risk undergoing MitraClip implantation in a three-year follow-up. Read More

Nat Med 2018 Nov 19. Epub 2018 Nov 19.

Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Ibrutinib plus venetoclax is a highly effective combination in mantle cell lymphoma. However, strategies to enable the evaluation of therapeutic response are required. Our prospective analyses of patients within the AIM study revealed genomic profiles that clearly dichotomized responders and nonresponders. Read More

J Sci Food Agric 2018 Nov 18. Epub 2018 Nov 18.

Graduate Program in Health and Development in the Mid West Region of Brazil, Federal University of Mato Grosso do Sul Post Code 79070-900 Campo Grande, Mato Grosso do Sul, Brazil.

Background: Fruits present high concentrations of bioactive compounds that are beneficial to health due to their antioxidant properties. New alternatives to vegetable oils with such properties have been studied. We determined the chemical compounds of Byrsonima cydoniifolia A. Read More

Int J Cancer 2018 Nov 16. Epub 2018 Nov 16.

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U-CLL). Subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter's transformation among all CLL. The underlying reasons for this divergent clinical behavior are not fully elucidated. Read More

Genetics 2018 Nov 15. Epub 2018 Nov 15.

Princeton University

Pif1 family helicases are found in virtually all eukaryotes. (Sc) encodes two Pif1 family helicases, ScPif1 and Rrm3. ScPif1 is multi-functional, required not only for maintenance of mitochondrial DNA but also for multiple distinct nuclear functions. Read More

EBioMedicine 2018 Oct 31. Epub 2018 Oct 31.

Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany. Electronic address:

J Neural Transm (Vienna) 2018 Oct 29. Epub 2018 Oct 29.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Hans Sachs Str. 6, 35039, Marburg, Germany.

Associations between mothers' and children's cortisol secretion parameters are well established. According to the bio-behavioral synchrony model, these associations reflect influences of the mother-child relationship, the child's social adjustment, and might also reflect shared genetic dispositions. From the bio-behavioral synchrony model, we predicted a stronger mother-child hair cortisol concentration (HCC) link in mothers showing highly adequate (compared to those showing less adequate) parenting behaviors and in children showing low (compared to those showing high) ADHD symptoms. Read More

J Med Biogr 2018 Nov 18;26(4):218-220. Epub 2018 Oct 18.

Breast Cancer Res Treat 2018 Oct 15. Epub 2018 Oct 15.

Marienhospital Bottrop, Bottrop, Germany.

Purpose: Neoadjuvant combination treatment with chemotherapy (CTX), trastuzumab (TZM), and pertuzumab (PTZ) has been shown to result in higher pathological complete response rates (pCR) in comparison with treatment with chemotherapy and trastuzumab (CTX/TZM). This analysis was aimed at real-world validation of these results from prospective randomized trials.

Methods: In a retrospective analysis conducted in the PRAEGNANT network, patients were eligible for inclusion if they had either received neoadjuvant therapy with CTX/TZM or chemotherapy, trastuzumab, and pertuzumab (CTX/TZM/PTZ) and subsequently underwent surgery for their primary breast cancer. Read More

Heart Vessels 2018 Oct 9. Epub 2018 Oct 9.

Department of Medicine II, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Observation of the time-to-pulmonary vein isolation (TTI) by a spiral mapping catheter has emerged as a valuable procedural parameter in cryoballoon pulmonary vein isolation (PVI). The 1st generation spiral mapping catheter (Achieve, SMC1) has been available as an 8-polar catheter with a distal loop diameter of 15 or 20 mm. The novel spiral mapping catheter (Achieve Advance, SMC2) was designed as a true guidewire and is available, in addition to the sizes of the SMC1, as a 10-polar mapping catheter with a distal loop diameter of 25 mm. Read More

Sci Rep 2018 Sep 26;8(1):14386. Epub 2018 Sep 26.

Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora" - University of Malaga- Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Department of Molecular Biology and Biochemistry; Campus de Teatinos, 29071, Málaga, Spain.

High-throughput metabolomics technologies can provide the quantification of metabolites levels across various biological processes in different tissues, organs and species, allowing the identification of genes underpinning these complex traits. Information about changes of metabolites during strawberry development and ripening processes is key to aiding the development of new approaches to improve fruit attributes. We used network-based methods and multivariate statistical approaches to characterize and investigate variation in the primary and secondary metabolism of seven domesticated and seven wild strawberry fruit accessions at three different fruit development and ripening stages. Read More

Drug Des Devel Ther 2018 6;12:2775-2783. Epub 2018 Sep 6.

Medical Affairs Department, EMS Pharma Inc., Hortolândia, Brazil,

Purpose: This study investigated the safety and efficacy of fixed-dose combination tablets of naproxen/esomeprazole magnesium and nimesulide/pantoprazole to determine if both regimens are equally suited to relieve pain in patients with osteoarticular diseases and dyspeptic symptoms.

Methods: Patients were randomly assigned to receive either nimesulide/pantoprazole (100 mg/20 mg) twice daily or naproxen/esomeprazole magnesium (500 mg/20 mg) twice daily for 14 days. The primary endpoint was defined as the mean change in modified Western Ontario and McMaster Universities Osteoarthritis Index pain subscale. Read More

Invest Ophthalmol Vis Sci 2018 Sep;59(11):4384-4391

Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Cognitive Neuroscience Department, Nijmegen, The Netherlands.

Purpose: To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients.

Methods: Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Read More

Front Pharmacol 2018 21;9:933. Epub 2018 Aug 21.

Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Principal mechanisms of arrhythmia have been derived from ventricular but not atrial cardiomyocytes of animal models despite higher prevalence of atrial arrhythmia (e.g., atrial fibrillation). Read More

J Glob Infect Dis 2018 Jul-Sep;10(3):166-168

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Extrapulmonary manifestations of tuberculosis (TB) are particularly frequent during childhood, and usually involve the lymph nodes and the skull. They are related to predisposing immunosuppression conditions. A patient affected by diabetes mellitus type 1 (DMT1) and congenital lamellar ichthyosis type 3 came at our attention with a 4-year history of recurrent parotitis and severe back pain and inferior limb hypomobility, which had lasted for 6 months. Read More

J Adv Prosthodont 2018 Aug 17;10(4):315-320. Epub 2018 Aug 17.

Department of Prosthetic Dentsitry and Biomedical Materials Research, Hannover Medical School, Hannover, Germany.

Purpose: Fractures, occlusal adjustments, or marginal corrections after removing excess composite cements result in rough surfaces of all-ceramic FPDs. These have to be polished to prevent damage of the surrounding tissues. The aim of this study was to evaluate the roughness of zirconia, silicate-ceramic, and composite after polish with different systems for intraoral use. Read More

J Adv Prosthodont 2018 Aug 17;10(4):308-314. Epub 2018 Aug 17.

Department of Prosthetic Dentistry and Biomedical Materials Research, Hannover Medical School, Hannover, Germany.

Purpose: Plasma activation of hydrophobic zirconia surfaces might be suitable to improve the bond strength of luting materials. The aim of this study was to analyze the influence of nonthermal argon-plasma on the shear bond strength (SBS) between zirconia and different combinations of 10-MDP adhesive systems and luting composites after artificial aging.

Materials And Methods: Two hundred forty Y-TZP specimens were ground automatically with 165 µm grit and water cooling. Read More

Cureus 2018 Jun 19;10(6):e2836. Epub 2018 Jun 19.

Division of Pediatric Neurosurgery, Department of Surgery and Anatomy, Ribeirão Preto Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BRA.

Pott's puffy tumor is a rare and severe complication of frontal sinusitis, characterized by the progressive swelling of the frontal soft tissues secondary to a subperiosteal abscess. Radiological imaging with ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) are important diagnostic tools in establishing diagnosis and treatment planning. Early surgery along with intravenous antibiotics are required in order to achieve a good recovery. Read More

J Family Med Prim Care 2018 May-Jun;7(3):538-541

Department of Clinical Immunology and Rheumatology, CMC, Vellore, Tamil Nadu, India.

Background: Data of musculoskeletal manifestations of tuberculosis (TB) are limited to case reports, series, or retrospective studies. Therefore, we conducted this study to create awareness among doctors about musculoskeletal manifestations of TB.

Materials And Methods: This was a prospective observational study conducted at a referral TB Hospital in North India in September and October 2016. Read More

Clin Neurol Neurosurg 2018 Oct 17;173:115-117. Epub 2018 Jul 17.

Neurosurgery and Orthopedic surgery, Cantonal Hospital of Fribourg, Switzerland.

In this report, we describe an uncommon presentation of a Pott's puffy tumor, which is defined as a subperiosteal abscess related to a chronic frontal sinusitis. This condition has become rare in our part of the world because of the widespread use of antibiotics. Clinical history, investigations, and management are presented. Read More

J Marital Fam Ther 2018 Aug 13. Epub 2018 Aug 13.

Alliant International University.

Emotionally Focused Couple Therapy (EFT) was developed based on the premise that couples get stuck in negative cycles fueled by their underlying primary emotions and unmet attachment needs (Johnson [2004], Creating connection: The practice of Emotionally Focused Couple Therapy). EFT therapists need to stay in touch with and regulate their own emotions when the tension rises in the sessions, while still staying open and vulnerable to their clients. Person-of-the-Therapist Training model (Aponte & Kissil [2016], The person of the therapist training model: Mastering the use of self) aims to increase therapists' understanding, awareness, and acceptance of their own personal issues to create a more empathic connection with their clients. Read More

Fundam Clin Pharmacol 2018 Aug 9. Epub 2018 Aug 9.

Klinik für Kardiologie II: Rhythmologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany.

Administration of digitalis in heart failure (HF) increases quality of life but does not carry a prognostic benefit. Digitalis is an indirect inhibitor of the Na /Ca exchanger (NCX), which is overexpressed in HF. We therefore used the cardiac glycoside ouabain in Ca imaging experiments and patch-clamp experiments in isolated ventricular myocytes from nonfailing transgenic NCX overexpressor mice (OE). Read More

Eur J Haematol 2018 Dec 25;101(6):766-773. Epub 2018 Oct 25.

Praxis für interdisziplinäre Onkologie & Hämatologie, Freiburg, Germany.

Objective: Azacitidine (Vidaza ) is the standard treatment for patients with higher-risk myelodysplastic syndromes (MDS) not eligible for allogeneic stem cell transplantation. In the noninterventional study PIAZA, we evaluated the effectiveness and safety of azacitidine treatment in 149 patients with higher-risk MDS, chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) in routine clinical practice.

Method: Patients were treated according to physician's discretion. Read More

Neurocirugia (Astur) 2018 Jul 27. Epub 2018 Jul 27.

Servicio de Neurocirugía, Hospital Universitario Miguel Servet, Zaragoza, España.

Pott's puffy tumour (PPT) is a rare entity that involves scalp swelling associated with subperiosteal abscess and cranial osteomyelitis, occasionally accompanied by intracranial infection. It is usually affiliated with frontal sinusitis, which is a typical but infrequent complication. On the contrary, Osteomyelitis by Actinomyces is rare and usually occurs at the mandibular level, with very few cases of cranial osteomyelitis caused by this bacterial specie, especially after traumatic brain injury. Read More

Invest Ophthalmol Vis Sci 2018 Jul;59(8):3220-3231

Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Purpose: To assess the occurrence and the disease expression of the common p.Asn1868Ile variant in patients with Stargardt disease (STGD1) harboring known, monoallelic causal ABCA4 variants.

Methods: The coding and noncoding regions of ABCA4 were sequenced in 67 and 63 STGD1 probands respectively, harboring monoallelic ABCA4 variants. Read More

Leukemia 2018 Jun 28. Epub 2018 Jun 28.

José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School, Homburg/Saar, Germany.

The predominant usage of VH4-34 and V3-21 and reports of stereotyped CDR3s suggest a shared antigenic target of B-cell receptors (BCR) from mantle cell lymphomas (MCL). To identify the target antigens of MCL-BCRs, BCRs from 21 patients and seven MCL cell lines were recombinantly expressed and used for antigen screening. The BCRs from 8/21 patients and 2/7 MCL cell lines reacted specifically with the autoantigen low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1). Read More

Eur J Neurol 2018 Nov 31;25(11):1365-e117. Epub 2018 Jul 31.

Medical Biology, Laboratory for Cardiovascular Physiology, AMC Center for Heart Failure Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background And Purpose: Cerebrovascular responses to head-of-bed positioning in patients with acute ischaemic stroke are heterogeneous, questioning the applicability of general recommendations on head positioning. Cerebral autoregulation is impaired to various extents after acute stroke, although it is unknown whether this affects cerebral perfusion during posture change. We aimed to elucidate whether the cerebrovascular response to head position manipulation depends on autoregulatory performance in patients with ischaemic stroke. Read More

Int J Mycobacteriol 2018 Apr-Jun;7(2):183-185

Department of Microbiology, Institute of Medical Science, BHU, Varanasi, Uttar Pradesh, India.

Tuberculosis (TB) is known to cause a wide variety of complications and atypical presentations. It usually presents with typical symptoms. Here, we present the unusual case of pulmonary TB with the involvement of lungs, brain, liver, spleen, vertebra, skin, left cervical lymph nodes, bone marrow, and heart. Read More

J Musculoskelet Neuronal Interact 2018 Jun;18(2):191-199

Department of Kinesiology and Sport, Pott College of Science, Engineering, and Education, University of Southern Indiana, Evansville, IN 47712.

Objectives: To explore throwing athletes as a prospective, within-subject controlled model for studying the response of the skeleton to exercise.

Methods: Male pre-pubertal throwing athletes (n=12; age=10.3±0. Read More

Adv Exp Med Biol 2018 May 31. Epub 2018 May 31.

Istituto Zooprofilattico Sperimentale della Sicilia A. Mirri, Barcellona Pozzo di Gotto, Italy.

During a routine abattoir inspection of pig carcasses and control activities of hunted wildlife in 2013, 118 large white pigs Sus scrofa domesticus, 474 Nebrodi black pigs and 135 wild boars Sus scrofa scrofa were submitted to anatomopathological examination to evaluate the presence of tuberculosis-like lesions. Localized and generalized granulomatous lesions were detected with a prevalence of about 25% in large white pigs, 13% in Nebrodi black pigs and 8.15% in wild boars. Read More

Autophagy 2018 25;14(8):1460-1461. Epub 2018 May 25.

a Sir William Dunn School of Pathology , University of Oxford , Oxford , UK.

Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment. Read More

Interact Cardiovasc Thorac Surg 2018 Nov;27(5):664-670

Department of Thoracic and Cardiovascular Surgery, RWTH University Hospital Aachen, Aachen, Germany.

Objectives: Sutureless aortic valve prostheses are gaining popularity due to the substantial reduction in cross-clamp time. In this study, we report our observations on the cusp-fluttering phenomenon of the Perceval bioprosthesis (LivaNova, London, UK) using a combination of technical and medical perspectives.

Methods: Between August 2014 and December 2016, a total of 108 patients (69% women) with a mean age of 78 years had aortic valve replacement using the Perceval bioprosthesis (34 combined procedures). Read More

Evol Med Public Health 2018 14;2018(1):100-105. Epub 2018 Apr 14.

Department of Biology, Tufts University, Medford, MA 02155, USA.

Night terrors, also known as sleep terrors, are an early childhood parasomnia characterized by screams or cries, behavioral manifestations of extreme fear, difficulty waking and inconsolability upon awakening. The mechanism causing night terrors is unknown, and a consistently successful treatment has yet to be documented. Here, we argue that cultural practices have moved us away from an ultimate solution: cosleeping. Read More

Sci Rep 2018 May 15;8(1):7607. Epub 2018 May 15.

Institute of Geobotany, Leibniz Universität Hannover, 30167, Hannover, Germany.

The effects of biodiversity on ecosystem functions have been extensively studied, but little is known about the effects of ecosystem functions on biodiversity. This knowledge is important for understanding biodiversity-ecosystem functioning relationships. Desertification reversal is a significant global challenge, but the factors that play key roles in this process remain unclear. Read More

JBI Database System Rev Implement Rep 2018 May;16(5):1153-1160

Department of Primary Care and Emergency, Military Police Hospital of Paraná, Brazil.

Review Question/objective: The objective of this review is to synthesize the best available evidence on the effectiveness of the application of extracellular matrix products as dressings or in topical form as treatment for venous, arterial and mixed leg ulcers, compared to compression therapy alone, any type of dressings and topical agents, or placebos in adults over 18 years in any care setting. Read More

Exp Gerontol 2018 Sep 26;110:46-53. Epub 2018 May 26.

Key Laboratory of Exercise and Health Sciences of Ministry of Education at the Shanghai University of Sport, 188 Hengren Road, Shanghai 200438, China. Electronic address:

Background: The genetic component of dyslipidemia has been studied in adults but little in older population. It is remains unknown regarding influence and interaction of APOA5 gene single nucleotide polymorphism (SNP) and habitual aerobic exercise (HAE) on changes of blood lipids and lipoprotein phenotypes in older Chinese adults.

Methods: Four-hundred-twenty-three old Chinese individuals with HAE were divided into hyperlipidemia and normal groups. Read More

J Mol Cell Cardiol 2018 Jul 8;120:42-52. Epub 2018 May 8.

Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany. Electronic address:

The genetic underpinnings that orchestrate the vertebrate heart rate are not fully understood yet, but of high clinical importance, since diseases of cardiac impulse formation and propagation are common and severe human arrhythmias. To identify novel regulators of the vertebrate heart rate, we deciphered the pathogenesis of the bradycardia in the homozygous zebrafish mutant hiphop (hip) and identified a missense-mutation (N851K) in Na/K-ATPase α1-subunit (atp1a1a.1). Read More

Circ Genom Precis Med 2018 May;11(5):e001992

Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany (J.P., K.H., H.K., M.L., M.S.)

Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is a novel strategy to treat hypercholesterolemia and reduce cardiovascular events. However, the potential role of circulating plasma PCSK9 concentrations as a diagnostic and predictive biomarker remains uncertain as of now. Here, we aimed to identify genetic variants associated with plasma PCSK9 and investigate possible causal effects on atherosclerotic vascular disease phenotypes. Read More

Int J Infect Dis 2018 Jul 7;72:11-15. Epub 2018 May 7.

NC Farma Group Hortolândia, São Paulo, Brazil.

Background: This study investigated the safety and efficacy of famciclovir compared to acyclovir in patients with herpes zoster, to determine whether the two regimens are equally effective for the treatment of patients with uncomplicated herpes zoster over a period of 7days.

Methods: Patients were randomly assigned to receive either famciclovir 500mg (one tablet) three times daily or acyclovir 800mg (two capsules) five times daily for 7 days. The primary endpoint was defined as the time to full crusting of herpes zoster lesions. Read More

J Hand Surg Asian Pac Vol 2018 Jun;23(2):297-301

‡ Department of Plastic Surgery, Erasmus MC, Rotterdam, The Netherlands.

The hemi-hamate arthroplasty for proximal interphalangeal joint (PIPJ) dorsal fracture dislocations relies on complete dislocation of the joint using the 'shotgun' approach which provides excellent exposure but damages the delicate intrinsic joint stabilisers. We present a new approach to the PIPJ when performing the hemi-hamate arthroplasty. The volar surgical approach involves freeing up the whole tendon sheath-periosteal unit as a single layer, and retracting this to one side. Read More

BMJ Case Rep 2018 Apr 25;2018. Epub 2018 Apr 25.

Department of Otolaryngology, Ninewells Hospital and Medical School, NHS Tayside, Dundee, Scotland, UK.

Pott's puffy tumour (PPT) is characterised by a subperiosteal abscess associated with osteomyelitis of the frontal bone-a rare complication of frontal sinusitis, more common in the paediatric population. We describe a case mimicking PPT, where abscess extension was facilitated by previous surgery. Usually patients with PPT would be systemically unwell, but our patient, a 63-year-old Caucasian man, was systemically well with a large swelling of his forehead. Read More

Sci Total Environ 2018 Sep 24;635:687-698. Epub 2018 Apr 24.

Institute for Environmental Sciences, University of Koblenz-Landau, Fortstrasse 7, 76829 Landau, Germany.

The aquatic environment is strongly connected to the surrounding agricultural landscapes, which regularly serve as sources of stressors such as agrochemicals. Genetically modified crops, which are cultivated on a large scale in many countries, may also act as stressors. Despite the commercial use of genetically modified organisms (GMOs) for over 20years, their impact on the aquatic environment came into focus only 10years ago. Read More

Rev Med Liege 2018 Apr;73(4):191-196

Service de Médecine interne générale, CHR Citadelle, Liège, Belgique.

Osteoarticular or skeletal tuberculosis is a clinical manifestation of extrapulmonary tuberculosis, occurring during the lympho-hematogenous spread of Mycobacterium tuberculosis from a pulmonary primary infection or reactivation of latent infection, years or even decades after the initial infection. Bone and joint tuberculosis is a rare disease with non-specific symptoms and radiological characteristics, often delaying diagnosis for more than a year after clinical onset. First-line hospital departments should develop a clinical suspicion when confronted with a subacute inflammatory bone or joint pathology in patients with underlying comorbidities, especially when coming from tuberculosis-endemic countries. Read More

Eur J Obstet Gynecol Reprod Biol 2018 May 20;224:125-130. Epub 2018 Mar 20.

Federal University of São Paulo, Brazil.

Hepatitis C virus (HCV) infection is a worldwide health problem. Based on results of a serosurvey, global prevalence is estimated to be 2,5%, and women account for about 35.8% of the cases. Read More

N Engl J Med 2018 03;378(13):1211-1223

From the Peter MacCallum Cancer Centre, Melbourne, VIC (C.S.T., M.A.A., R.A., S.H., R.J.H., K.B., G.T., J.D.I., M.B., D.W., S.L., S.-J.D., M.A.D., J.F.S., A.W.R.), and the Victorian Comprehensive Cancer Centre (C.S.T., M.A.A., R.A., S.H., R.J.H., K.B., D.W., S.-J.D., M.A.D., J.F.S., A.W.R.), the Faculty of Medicine (C.S.T., R.J.H., S.-J.D., M.A.D., J.F.S., A.W.R.) and Centre for Cancer Research (S.-J.D., M.A.D.), University of Melbourne, the Department of Clinical Haematology and Bone Marrow Transplantation, the Royal Melbourne Hospital (C.S.T., M.A.A., K.B., J.F.S., A.W.R.), and the Division of Cancer and Haematology, Walter and Eliza Hall Institute of Medical Research (M.A.A., A.W.R.), Parkville, VIC - all in Australia; and the University Hospital of Schleswig-Holstein, Kiel (C.P.), and Klinikum der Universität, Ludwig-Maximilian University of Munich, Munich (M.D.) - both in Germany.

Background: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. Read More

Indian J Orthop 2018 Mar-Apr;52(2):100-107

Department of Microbiology, University College of Medical Sciences, GTB Hospital, New Delhi, India.

Drug-resistant spinal tuberculosis (TB) is an emerging health problem in both developing and developed countries. In this review article, we aim to define management protocols for suspicion, diagnosis, and treatment of such patients. Spinal TB is a deep-seated paucibacillary lesion, and the demonstration of acid-fast bacilli on Ziehl-Neelsen staining is possible only in 10%-30% of cases. Read More

Braz J Biol 2018 Mar 12. Epub 2018 Mar 12.

Departamento de Botânica, Universidade Federal Rural de Pernambuco - UFRPE, CEP 52171-900, Recife, PE, Brasil.

We evaluated the response of the biomass of aquatic macrophytes under limnological changes after water level fluctuation (WLF) of two tropical reservoirs (R1 and R2), located in northeastern Brazil. Initially we tested the hypothesis that post-WLF limnological conditions and biomass of macrophytes increase or decrease, depending on the variable or species. We monitored a 4 × 50 m permanent plot, in four expeditions per period (pre- or post-WLF), assessing species biomass and 10 limnological variables. Read More