139 results match your criteria Posttraumatic Syringomyelia


Surgical Treatment of Upper Extremity Segmental Myoclonus in an Adolescent with Chiari Malformation and Cervicothoracic Syrinx.

Pediatr Neurosurg 2021 May 11:1-6. Epub 2021 May 11.

Division of Neurosurgery, Department of Neurosurgery, Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Myoclonus is an involuntary movement disorder characterized by semirhythmic jerking movements of muscle groups but is rarely seen in association with Chiari malformation type I (CM-1). CM-1 is a frequently encountered clinical entity in pediatric neurosurgery characterized by caudal displacement of the cerebellar tonsils with or without syringomyelia. We report a pediatric patient who presented with upper extremity myoclonus and was found to have CM-1 and a complex septated cervicothoracic syrinx eccentric to the left. Read More

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Transplantation of Human Neural Precursor Cells Reverses Syrinx Growth in a Rat Model of Post-Traumatic Syringomyelia.

Neurotherapeutics 2021 Jan 19. Epub 2021 Jan 19.

Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Posttraumatic syringomyelia (PTS) is a serious condition of progressive expansion of spinal cord cysts, affecting patients with spinal cord injury years after injury. To evaluate neural cell therapy to prevent cyst expansion and potentially replace lost neurons, we developed a rat model of PTS. We combined contusive trauma with subarachnoid injections of blood, causing tethering of the spinal cord to the surrounding vertebrae, resulting in chronically expanding cysts. Read More

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January 2021

Myelopexy: A novel technique in posttraumatic syringomyelia.

Neurocirugia (Astur : Engl Ed) 2020 Dec 11. Epub 2020 Dec 11.

Department of Neurosurgery, University Hospital Miguel Servet, Zaragoza, Spain.

Posttraumatic syringomyelia (PTS) is a well-reported phenomenon that usually takes place in the long-term course of patients following spinal cord injury. Different surgical procedures have been described: spinal cordectomy is usually a last option technique, but might be an excellent choice in patients with severe spinal cord injuries. We present a young patient with complete spinal cord injury after spine trauma, who developed posttraumatic syringomyelia with progressive motor deterioration twelve years after fixation. Read More

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December 2020

Development of pre-syrinx state and syringomyelia following a minor injury: a case report.

J Med Case Rep 2020 Nov 18;14(1):223. Epub 2020 Nov 18.

Dept. of Neurosurgery, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.

Background: A generally accepted rule is that posttraumatic syringomyelia (PTS) results from spinal cord injury (SCI).

Case Presentation: Here, we report the development of syringomyelia without SCI in a 54-year-old Caucasian man following a mild motor vehicle accident. The computed tomography on admission excluded an injury of the spine. Read More

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November 2020

Treatment of posttraumatic syringomyelia: evidence from a systematic review.

Acta Neurochir (Wien) 2020 10 20;162(10):2541-2556. Epub 2020 Aug 20.

Institute of Social Medicine and Health Systems Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Background: Following spinal cord injury (SCI), the routine use of magnetic resonance imaging (MRI) resulted in an incremental diagnosis of posttraumatic syringomyelia (PTS). However, facing four decades of preferred surgical treatment of PTS, no clear consensus on the recommended treatment exists. We review the literature on PTS regarding therapeutic strategies, outcomes, and complications. Read More

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October 2020

Syringo-Subarachnoid Shunt Placement: A Minimally Invasive Technique Using Fixed Tubular Retractors-Three Case Reports and Literature Review.

Int J Spine Surg 2020 Apr 30;14(2):133-139. Epub 2020 Apr 30.

Department of Neurosurgery, Aster CMI Hospital, Karnataka, India.

Background: Placement of a syringo-subarachnoid shunt as a surgical management for syringomyelia has been well described in the literature. Good results in terms of clinical and radiological improvement have been documented especially for posttraumatic syringomyelia. Traditionally, this has been performed using open approaches which are fraught with risks of cerebrospinal fluid leak, delayed wound healing, and increased postoperative pain. Read More

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Syringomyelia in Patient with Concurrent Posttraumatic Hydrocephalus and Tethered Spinal Cord: Implications for Surgical Management.

World Neurosurg 2020 06 7;138:163-168. Epub 2020 Mar 7.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: Posttraumatic syringomyelia is a significant source of disability following spinal cord injury (SCI). Despite this, its etiology and optimal treatment remain controversial. Early identification of and intervention at a presyrinx state may halt progression. Read More

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Ultrasound-guided Syringosubarachnoid Shunt Insertion for Cervicothoracic Syringomyelia.

Clin Spine Surg 2020 06;33(5):185-191

Department of Neurological Surgery, Weill Cornell Brain and Spine Center, New York-Presbyterian Hospital, New York, NY.

Syrinx can be secondary to many etiologies, including tumor, Chiari malformation, tethered cord, or sequelae of infection or trauma. Posttraumatic syringomyelia, a potential complication of spinal injury, can insidiously present years after the initial event. Expansion of the cerebrospinal fluid-filled cyst can lead to pain, sensorimotor deficits, and myelopathy. Read More

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Subacute Traumatic Ascending Myelopathy in a 28-Year-Old Man: A Rare Case.

World Neurosurg 2019 Aug 28;128:143-148. Epub 2019 Apr 28.

Department of Neurosurgery, University Hospital Dusseldorf, Dusseldorf, Germany.

Background: Subacute posttraumatic ascending myelopathy (SPAM) involves the rise in high signal intensity on T2-weighted images ≥4 vertebral segments above the initial injured site, and it usually occurs within the first few weeks after the injury. The pathophysiologic mechanisms of traumatic spinal cord damage are not clearly understood; however, there are some pathophysiologic processes such as arterial thrombosis, venous thrombosis, congestive ischemia, inflammatory or autoimmune reaction, and infection in the form of meningitis or myelitis that could lead to SPAM.

Case Description: We present a case of T7 fracture because of left shoulder gunshot injury and ascending myelopathy up to the C2 vertebra level, which occurred 1 week after the gunshot injury, without pretraumatic cervical injury or syringomyelia. Read More

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Subacute posttraumatic ascending myelopathy (SPAM): A potential complication of subarachnoid shunt for syringomyelia?

J Spinal Cord Med 2020 09 29;43(5):714-718. Epub 2018 Aug 29.

Department of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

: Treatment of primary spinal syringomyelia is still controversial. Among others, shunting syrinx fluid to the subarachnoid, peritoneal or pleural space has been utilized with varying success. Shunt obstruction, migration, and infection represent the most common complications of these procedures. Read More

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September 2020

Rhythmic Neck Muscle Spasms and Upper Limb Muscle Myoclonic Jerks as an Unusual Initial Presentation of Posttraumatic Cervicothoracic Syringomyelia: A Case Report.

PM R 2018 10 14;10(10):1119-1121. Epub 2018 Mar 14.

Department of Physical Medicine and Rehabilitation, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taiwan; No. 5, Fuxing St, Guishan Dist, Taoyuan City 333, Taiwan.

Posttraumatic syringomyelia with an initial presentation of involuntary movement is rare. We describe a 25-year-old patient who sustained complete traumatic spinal cord injury at the thoracic level and presented with rhythmic neck muscle spasms and upper limb muscle myoclonic jerks 1 month after trauma. Magnetic resonance imaging revealed syrinx formation between C3 and T1. Read More

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October 2018

Cell Therapy as a New Approach to the Treatment of Posttraumatic Syringomyelia.

World Neurosurg 2017 Nov 10;107:1047.e5-1047.e8. Epub 2017 Aug 10.

Neurosurgery Service and Neurological Cell Therapy Unit, Department of Surgery, Hospital Puerta de Hierro-Majadahonda, and Autonomous University, Madrid, Spain.

Background: Cell transplantation with autologous bone marrow-derived mesenchymal stromal cells (MSCs) seems to be a therapeutic promise for patients with established spinal cord injury, achieving improvement in their quality of life, but there is no experience with the application of this type of cell therapy in patients suffering posttraumatic syringomyelia.

Objective: To study the possible utility of cell therapy with autologous MSCs in posttraumatic syringomyelia.

Methods: A 40-year-old man with complete paraplegia since 1991 as a consequence of a Th4 vertebral fracture showed a great posttraumatic syringomyelia that extended up to C2 vertebral level, without signs of recent worsening. Read More

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November 2017

Characteristics of CSF Velocity-Time Profile in Posttraumatic Syringomyelia.

AJNR Am J Neuroradiol 2017 Sep 20;38(9):1839-1844. Epub 2017 Jul 20.

From Neuroscience Research Australia (J.Y., B.B.L., L.B.), Randwick, New South Wales, Australia.

Background And Purpose: The development of syringomyelia has been associated with changes in CSF flow dynamics in the spinal subarachnoid space. However, differences in CSF flow velocity between patients with posttraumatic syringomyelia and healthy participants remains unclear. The aim of this work was to define differences in CSF flow above and below a syrinx in participants with posttraumatic syringomyelia and compare the CSF flow with that in healthy controls. Read More

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September 2017

Spontaneous resolution of an extensive posttraumatic syrinx.

Neurology 2016 09 19;87(12):1299-301. Epub 2016 Aug 19.

From the Spinal Cord Injury Center (T.K., J.R., C.R.J., M.H., A.C.), University Hospital Balgrist, Zurich; Cantonal Hospital St. Gallen (T.K., R.H.), Switzerland; and ICORD (C.R.J.), University of British Columbia, Vancouver, Canada.

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September 2016

Longitudinal measurements of syrinx size in a rat model of posttraumatic syringomyelia.

J Neurosurg Spine 2016 Jun 26;24(6):941-8. Epub 2016 Feb 26.

Faculty of Medicine and Health Sciences and.

OBJECTIVE Syringomyelia pathophysiology is commonly studied using rodent models. However, in vivo studies of posttraumatic syringomyelia have been limited by the size of animals and lack of reliable noninvasive evaluation techniques. Imaging the rat spinal cord is particularly challenging because the spinal cord diameter is approximately 1-3 mm, and pathological lesions within the spinal cord parenchyma are even smaller. Read More

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Syringosubarachnoid shunting using a myringotomy tube.

Surg Neurol Int 2016 7;7(Suppl 1):S8-S11. Epub 2016 Jan 7.

Department of Neurosurgery, Medical College of Wisconsin, Froedtert Hospital, Milwaukee, WI 53226, USA.

Background: Syringomyelia results from obstruction of cerebrospinal fluid (CSF) flow due to a multitude of causes. Often symptoms of pain, weakness, and sensory disturbance are progressive and require surgical treatment. We present here a rare technique for syringosubarachnoid shunting. Read More

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February 2016

Direct-trauma model of posttraumatic syringomyelia with a computer-controlled motorized spinal cord impactor.

J Neurosurg Spine 2016 May 29;24(5):797-805. Epub 2016 Jan 29.

Faculty of Medicine and Health Sciences and.

OBJECTIVE The pathogenesis of posttraumatic syringomyelia remains enigmatic and is not adequately explained by current theories. Experimental investigations require a reproducible animal model that replicates the human condition. Current animal models are imperfect because of their low reliability, severe neurological deficits, or dissimilar mechanism of injury. Read More

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The characteristics of posttraumatic syringomyelia.

Spinal Cord 2016 Jun 1;54(6):463-6. Epub 2015 Dec 1.

Clinical Trial Unit, Swiss Paraplegic Centre, Nottwil, Switzerland.

Study Design: Retrospective cross-sectional study.

Objectives: To investigate the characteristics of posttraumatic symptomatic syringomyelia after spinal cord injury (SCI).

Setting: Swiss Paraplegic Centre, Nottwil, Switzerland. Read More

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Intracranial hypotension after syringopleural shunting in posttraumatic syringomyelia: Case report and review of the literature.

Asian J Neurosurg 2015 Apr-Jun;10(2):158-61

Department of Neurosurgery, The Alfred Hospital, Victoria, Australia ; Department of Surgery, Monash University, Victoria, Australia.

We report a case of a 45-year-old male with a syringopleural shunt who developed intracranial hypotension. The patient presented with 2 weeks history of worsening headache and back pain, on a background of having had a syringopleural shunt inserted for a thoracic posttraumatic syrinx. Computerized tomography imaging of the brain revealed bilateral subdural fluid collections. Read More

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The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia.

Authors:
Zhiqiang Hu Jian Tu

Biomed Res Int 2015 13;2015:831490. Epub 2015 Jan 13.

Prince of Wales Clinical School, The University of New South Wales, Sydney, NSW 2052, Australia.

The pathophysiology of posttraumatic syringomyelia is incompletely understood. We examined whether local ischemia occurs after spinal cord injury. If so, whether it causes neuronal mitochondrial dysfunction and depletion, and subsequent energy metabolism impairment results in cell starvation of energy and even cell death, contributing to the enlargement of the cavity. Read More

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November 2015

C-5 palsy after cerebrospinal fluid diversion in posttraumatic syringomyelia: case report.

J Neurosurg Spine 2015 Apr 6;22(4):394-8. Epub 2015 Feb 6.

Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Syringomyelia is a potentially debilitating disease that involves abnormal CSF flow mechanics; its incidence after traumatic spinal cord injury (SCI) is approximately 15%. Treatment consists of restoration of CSF flow, typically via arachnoidolysis and syrinx decompression. The authors present a case of pronounced syringomyelia in a patient with concomitant severe cervical myelomalacia to demonstrate unilateral C-5 palsy as a potential complication of aggressive syrinx decompression at a remote level. Read More

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Posttraumatic syringomyelia: a technical note.

Turk Neurosurg 2014 ;24(4):618-22

Koc University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Aim: Previous studies have not identified a preferred surgical technique to treat posttraumatic syringomyelia. Both syringopleural shunting and arachnoidolysis are used in neurosurgery practice for the surgical treatment of posttraumatic syringomyelia. In this study, we present a new technique designed to achieve a better outcome following surgery. Read More

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Post-traumatic syringomyelia: outcome predictors.

Clin Neurol Neurosurg 2014 Sep 17;124:44-50. Epub 2014 Jun 17.

Department of Neurosurgery, University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA.

Objective: To identify risk factors that predispose to post-traumatic syringomyelia (PTS) and describe the outcome of surgical management.

Methods: Retrospective cohort study of 27 patients with post-traumatic syringomyelia. Spinal cord injury of these patients spanned the period from 1963 to 2008. Read More

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September 2014

Arachnolysis or cerebrospinal fluid diversion for adult-onset syringomyelia? A Systematic review of the literature.

World Neurosurg 2015 May 27;83(5):829-35. Epub 2014 Jun 27.

Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Electronic address:

Objective: To identify surgical practice patterns in the literature for nonpediatric syringomyelia by systematic review and to determine the following: 1) What is the best clinical practice of cerebrospinal fluid (CSF) diversion to maximize clinical improvement or to achieve the lowest recurrence rate? 2) Does arachnolysis, rather than CSF diversion, lead to prolonged times to clinical recurrence?

Methods: A database search comprising PubMed, Cochrane Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and Cochrane Database of Systematic Reviews was conducted to find pertinent articles on postinfectious, posttraumatic, or idiopathic syringomyelia.

Results: An advanced PubMed search in August 2012 yielded 1350 studies, including 12 studies meeting Oxford Centre for Evidence-Based Medicine criteria for level IV evidence as a case series, with a total of 410 patients (mean age, 39 years). Data on 486 surgeries were collected. Read More

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Syringomyelia coexisting with guillain-barre syndrome.

Ann Rehabil Med 2013 Oct 29;37(5):745-9. Epub 2013 Oct 29.

Department of Physical Medicine and Rehabilitation, Kyung Hee University College of Medicine, Seoul, Korea.

Guillain-Barre syndrome (GBS) and syringomyelia are diseases of different entities. GBS is an acute post-infectious autoimmune disease which is mediated by autoantibodies against the myelin of peripheral nerves. Syringomyelia is a chronic disease characterized by a cavity extending longitudinally inside the spinal cord. Read More

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October 2013

Subarachnoid-subarachnoid bypass: a new surgical technique for posttraumatic syringomyelia.

J Neurosurg Spine 2013 Apr 22;18(4):382-7. Epub 2013 Feb 22.

Department of Orthopedic Surgery, Japan Labour Health and Welfare Organization, Spinal Injuries Center, Fukuoka, Japan.

Object: The origin of posttraumatic syringomyelia is not completely understood. With respect to posttraumatic syringomyelia, the optimum management strategy for patients with spinal cord injury has also not been established. The authors hypothesized that reconstruction of the subarachnoid channels would reestablish CSF flow, thereby addressing the underlying cause of the syrinx formation. Read More

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Treatment of posttraumatic syringomyelia.

Authors:
Jörg Klekamp

J Neurosurg Spine 2012 Sep 13;17(3):199-211. Epub 2012 Jul 13.

Department of Neurosurgery, Christliches Krankenhaus, Quakenbrück, Germany.

Object: This paper presents results of a prospective study for patients undergoing surgery for posttraumatic syringomyelia between 1991 and 2010.

Methods: A group of 137 patients with posttraumatic syringomyelia were evaluated (mean age 45 ± 13 years, mean follow-up 51 ± 51 months) with pre- and postoperative MRI and clinical examinations presenting in this period and followed prospectively by outpatient visits and questionnaires. Surgery was recommended for symptomatic patients with a progressive course. Read More

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September 2012

Air gun impactor--a novel model of graded white matter spinal cord injury in rodents.

J Reconstr Microsurg 2012 Oct 18;28(8):561-8. Epub 2012 Jun 18.

Department of Physiology, Center of Excellence for Research and Teaching of Matrix Biology and Nanotechnology, Network of CoE BioMedTech Silesia; School of Medicine in Katowice, Medical University of Silesia, ul. Medyków 4, Katowice, Poland.

Understanding mechanisms of spinal cord injury and repair requires a reliable experimental model. We have developed a new device that produces a partial damage of spinal cord white matter by means of a precisely adjusted stream of air applied under high pressure. This procedure is less invasive than standard contusion or compression models and does not require surgical removal of vertebral bones. Read More

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October 2012

Fluid outflow in a large-animal model of posttraumatic syringomyelia.

Neurosurgery 2012 Aug;71(2):474-80; discussion 480

Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.

Background: Posttraumatic syringomyelia affects approximately 28% of spinal cord injury patients, and current treatments are often ineffective. The pathogenesis of this condition remains poorly understood. Previous reports have focused on pathways and mechanisms of fluid inflow; however, disturbances of fluid outflow mechanisms and pathways may be important in syrinx formation and enlargement. Read More

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