2,021 results match your criteria Posttraumatic Epilepsy


A review of seizures and epilepsy following traumatic brain injury.

J Neurol 2020 May 22. Epub 2020 May 22.

Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

Traumatic brain injury (TBI) is one of the commonest presentations to emergency departments and is associated with seizures carrying different significance at different stages following injury. We describe the epidemiology of early and late seizures following TBI, the significance of intracranial haemorrhage of different types in the risk of later epilepsy and the gaps in current understanding of risk factors contributing to the risk of post-traumatic epilepsy (PTE). The delay from injury to epilepsy presents an opportunity to understand the mechanisms underlying changes in the brain and how they may reveal potential targets for anti-epileptogenic therapy. Read More

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http://dx.doi.org/10.1007/s00415-020-09926-wDOI Listing

Epidemiology of traumatic brain injury-associated epilepsy in western China: An analysis of multicenter data.

Epilepsy Res 2020 May 11;164:106354. Epub 2020 May 11.

Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China. Electronic address:

Objectives: This study aims to explore the probability of developing posttraumatic epilepsy (PTE) in the following 8 years after traumatic brain injury (TBI), the risk factors associated with PTE and its cumulative prevalence.

Methods: This is a retrospective follow-up study of patients with traumatic brain injury (TBI) discharged from the West China Hospital between January 1, 2011 and December 31, 2017, Chengdu Shang Jin Nan Fu Hospital and Sichuan Provincial People's Hospital from January 1, 2013 to March 1, 2015. We used forward stepwise method to build the final multivariate cox proportional hazard regression model to obtain estimates of hazard ratio (HR) of PTE and 95% confidence intervals (CI). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106354DOI Listing

Post-traumatic Stress Disorder With Flashbacks of an Old Childhood Memory Triggered by Right Temporal Lobe Epilepsy Surgery in Adulthood.

Front Psychiatry 2020 28;11:351. Epub 2020 Apr 28.

Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

Background: A plethora of data show that the hippocampus and the amygdala are involved in post-traumatic stress disorder (PTSD). Neural dysfunctions leading to PTSD (e.g. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198875PMC

Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure.

Iran J Basic Med Sci 2020 Jan;23(1):63-70

Faculty of Pharmacy, Department of Toxicology, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the histopathological and molecular modifications induced by seizures on traumatized brain. Read More

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http://dx.doi.org/10.22038/IJBMS.2019.37558.8932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206845PMC
January 2020

Combination Therapy of Gabapentin and N-Acetylcysteine Against Posttraumatic Epilepsy in Rats.

Neurochem Res 2020 May 5. Epub 2020 May 5.

Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.

Traumatic brain injury (TBI) is a major public health problem worldwide that is associated with increased mortality and morbidity. Posttraumatic epilepsy (PTE) is one of the sequelae of TBI. The aim of this study was to investigate the role of N-acetylcysteine (NAC) as an adjuvant on the efficacy of levetiracetam (LEV) and gabapentin (GBP) in PTE model encouraged by pentylenetetrazol (PTZ) after mild-TBI in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1007/s11064-020-03042-xDOI Listing

An Exploratory Report on Electrographic Changes in the Cerebral Cortex Following Mild Traumatic Brain Injury with Hyperthermia in the Rat.

Ther Hypothermia Temp Manag 2020 May 5. Epub 2020 May 5.

The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Traumatic brain injury (TBI) has the potential to perturb perception by disrupting electrical propagation within and between the thalamus and cerebral cortex. Moderate and severe TBI may result in posttraumatic epilepsy, a condition characterized by convulsive tonic-clonic seizures. Spike/wave discharges (SWDs) of generalized nonconvulsive seizures, also called absence seizures, may also occur as a consequence of brain trauma. Read More

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http://dx.doi.org/10.1089/ther.2020.0002DOI Listing

Early increase in cortical T2 relaxation is a prognostic biomarker for the evolution of severe cortical damage, but not for epileptogenesis, after experimental traumatic brain injury.

J Neurotrauma 2020 Apr 29. Epub 2020 Apr 29.

A I Virtanen Institute for Molecular Sciences, 214400, University of Eastern Finalnd, Neulaniementie 2, Kuopio, Finland, 70211;

Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation MRI predicts the progression of perilesional cortical pathology and epileptogenesis. The EPITARGET animal cohort used for MRI analysis included 120 adult male Sprague-Dawley rats with TBI induced by lateral fluid-percussion injury and 24 sham-operated controls. Read More

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http://dx.doi.org/10.1089/neu.2019.6796DOI Listing

α-Helical protein absorption at post-traumatic epileptic foci monitored by Fourier transform infrared mapping.

J Biosci 2020 ;45

Center of Cooperative Innovation for Judicial Civilization, Beijing 100088, China.

Tissue analysis by Fourier transform infrared (FTIR) imaging can determine the biodistribution of molecules, without pre-analytical modification. We aimed to study the infrared spectroscopic changes of α-helical proteins at post-traumatic epileptic (PTE) foci by FTIR. FITR mapping was applied to detect α-helical proteins in rat brain tissue samples with post-traumatic epilepsy. Read More

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January 2020

130 Temporal Lobe Epilepsy: Is It in Your Differential Diagnosis? Two Case Reports.

CNS Spectr 2020 Apr;25(2):282

Independent Practitioner, Colorado Springs, CO.

Temporal Lobe Epilepsy: Is it in your differential diagnosis? Two Case Reports.

Objective: Temporal Lobe Epilepsy (TLE), also referred as Complex Partial Seizures, is a medical diagnosis that must be considered in the pediatric, adolescent, and adult population presenting for psychiatric care. Mood disorders are common in people with epilepsy, with a prevalence rate of 20 to 50%. Read More

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http://dx.doi.org/10.1017/S1092852920000462DOI Listing

The Role of the SLC Transporters Protein in the Neurodegenerative Disorders.

Clin Psychopharmacol Neurosci 2020 May;18(2):174-187

The solute carrier (SLC) superfamily is one of the major sub-groups of membrane proteins in mammalian cells. The solute carrier proteins include more than 400 different membrane-spanning solute carriers organized with 65 families in the human. In solute carrier family neurons, neurotransmitter is considered to be a pharmacological target of neuropsychiatric drugs because of their important role in the recovery of neurotransmitters such as GABA, glutamate, serotonin, dopamine and noradrenaline and regulation of their concentration in synaptic regions. Read More

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http://dx.doi.org/10.9758/cpn.2020.18.2.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236796PMC

Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy.

Cell Mol Neurobiol 2020 Apr 21. Epub 2020 Apr 21.

Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

Epilepsy is a neurological disorder characterized by the occurrence of spontaneous and recurrent seizures. In post-traumatic epilepsy (PTE), the mechanism of epileptogenesis is very complex and seems to be linked with voltage-gated ion channels. Dehydroepiandrosterone (DHEA), a neurosteroid have shown beneficial effect against various neurological disorders. Read More

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http://dx.doi.org/10.1007/s10571-020-00851-0DOI Listing
April 2020
2.506 Impact Factor

Biomarkers for posttraumatic epilepsy.

Epilepsy Behav 2020 Apr 18:107080. Epub 2020 Apr 18.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland.

A biomarker is a characteristic that can be objectively measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Biomarker modalities include molecular, histologic, radiographic, or physiologic characteristics. To improve the understanding and use of biomarker terminology in biomedical research, clinical practice, and medical product development, the Food and Drug Administration (FDA)-National Institutes of Health (NIH) Joint Leadership Council developed the BEST Resource (Biomarkers, EndpointS, and other Tools). Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107080DOI Listing

Case Series: Unilateral Amygdala Ablation Ameliorates Post-Traumatic Stress Disorder Symptoms and Biomarkers.

Neurosurgery 2020 Apr 7. Epub 2020 Apr 7.

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia.

Background: Post-traumatic stress disorder is a severe psychobiological disorder associated with hyperactivity of the amygdala, particularly on the right side. Highly selective laser ablation of the amygdalohippocampal complex is an effective neurosurgical treatment for medically refractory medial temporal lobe epilepsy that minimizes neurocognitive deficits relative to traditional open surgery.

Objective: To examine the impact of amygdalohippocampotomy upon symptoms and biomarkers of post-traumatic stress disorder. Read More

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http://dx.doi.org/10.1093/neuros/nyaa051DOI Listing

Posttraumatic epilepsy in intensive care unit-treated pediatric traumatic brain injury patients.

Epilepsia 2020 Apr 28;61(4):693-701. Epub 2020 Mar 28.

Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objective: Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify the clinical and radiological risk factors associated with PTE in a pediatric TBI population treated in an intensive care unit (ICU). Read More

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http://dx.doi.org/10.1111/epi.16483DOI Listing

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Authors:
Paul M Thompson Neda Jahanshad Christopher R K Ching Lauren E Salminen Sophia I Thomopoulos Joanna Bright Bernhard T Baune Sara Bertolín Janita Bralten Willem B Bruin Robin Bülow Jian Chen Yann Chye Udo Dannlowski Carolien G F de Kovel Gary Donohoe Lisa T Eyler Stephen V Faraone Pauline Favre Courtney A Filippi Thomas Frodl Daniel Garijo Yolanda Gil Hans J Grabe Katrina L Grasby Tomas Hajek Laura K M Han Sean N Hatton Kevin Hilbert Tiffany C Ho Laurena Holleran Georg Homuth Norbert Hosten Josselin Houenou Iliyan Ivanov Tianye Jia Sinead Kelly Marieke Klein Jun Soo Kwon Max A Laansma Jeanne Leerssen Ulrike Lueken Abraham Nunes Joseph O' Neill Nils Opel Fabrizio Piras Federica Piras Merel C Postema Elena Pozzi Natalia Shatokhina Carles Soriano-Mas Gianfranco Spalletta Daqiang Sun Alexander Teumer Amanda K Tilot Leonardo Tozzi Celia van der Merwe Eus J W Van Someren Guido A van Wingen Henry Völzke Esther Walton Lei Wang Anderson M Winkler Katharina Wittfeld Margaret J Wright Je-Yeon Yun Guohao Zhang Yanli Zhang-James Bhim M Adhikari Ingrid Agartz Moji Aghajani André Aleman Robert R Althoff Andre Altmann Ole A Andreassen David A Baron Brenda L Bartnik-Olson Janna Marie Bas-Hoogendam Arielle R Baskin-Sommers Carrie E Bearden Laura A Berner Premika S W Boedhoe Rachel M Brouwer Jan K Buitelaar Karen Caeyenberghs Charlotte A M Cecil Ronald A Cohen James H Cole Patricia J Conrod Stephane A De Brito Sonja M C de Zwarte Emily L Dennis Sylvane Desrivieres Danai Dima Stefan Ehrlich Carrie Esopenko Graeme Fairchild Simon E Fisher Jean-Paul Fouche Clyde Francks Sophia Frangou Barbara Franke Hugh P Garavan David C Glahn Nynke A Groenewold Tiril P Gurholt Boris A Gutman Tim Hahn Ian H Harding Dennis Hernaus Derrek P Hibar Frank G Hillary Martine Hoogman Hilleke E Hulshoff Pol Maria Jalbrzikowski George A Karkashadze Eduard T Klapwijk Rebecca C Knickmeyer Peter Kochunov Inga K Koerte Xiang-Zhen Kong Sook-Lei Liew Alexander P Lin Mark W Logue Eileen Luders Fabio Macciardi Scott Mackey Andrew R Mayer Carrie R McDonald Agnes B McMahon Sarah E Medland Gemma Modinos Rajendra A Morey Sven C Mueller Pratik Mukherjee Leyla Namazova-Baranova Talia M Nir Alexander Olsen Peristera Paschou Daniel S Pine Fabrizio Pizzagalli Miguel E Rentería Jonathan D Rohrer Philipp G Sämann Lianne Schmaal Gunter Schumann Mark S Shiroishi Sanjay M Sisodiya Dirk J A Smit Ida E Sønderby Dan J Stein Jason L Stein Masoud Tahmasian David F Tate Jessica A Turner Odile A van den Heuvel Nic J A van der Wee Ysbrand D van der Werf Theo G M van Erp Neeltje E M van Haren Daan van Rooij Laura S van Velzen Ilya M Veer Dick J Veltman Julio E Villalon-Reina Henrik Walter Christopher D Whelan Elisabeth A Wilde Mojtaba Zarei Vladimir Zelman

Transl Psychiatry 2020 Mar 20;10(1):100. Epub 2020 Mar 20.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i. Read More

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http://dx.doi.org/10.1038/s41398-020-0705-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083923PMC
March 2020
4.360 Impact Factor

Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.

Clin EEG Neurosci 2020 Mar 18:1550059420909676. Epub 2020 Mar 18.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Posttraumatic stress disorder (PTSD) co-occurring with mild traumatic brain injury (mTBI) is common in veterans. Worse clinical outcome in those with PTSD has been associated with decreased serum neurosteroid levels. Furthermore, decreased cortical thickness has been associated with both PTSD and mTBI. Read More

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http://dx.doi.org/10.1177/1550059420909676DOI Listing

Post-Traumatic West Syndrome due to Abusive Head Trauma in Two Infants with Different Brain Imaging Findings.

Tohoku J Exp Med 2020 03;250(3):167-171

Department of Pediatrics, Nagoya City West Medical Center.

Abusive head trauma (AHT), commonly known as shaken baby syndrome, is a cranial injury of infants and young children. AHT is an important cause of morbidity and mortality in young children, particularly those younger than 12 months of age. We describe two patients who developed West syndrome, which is a severe epilepsy syndrome composed of the triad of infantile spasms, hypsarrhythmia on electroencephalography, and developmental arrest or regression, possibly attributable to AHT. Read More

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http://dx.doi.org/10.1620/tjem.250.167DOI Listing

Acute Effects and the Dreamy State Evoked by Deep Brain Electrical Stimulation of the Amygdala: Associations of the Amygdala in Human Dreaming, Consciousness, Emotions, and Creativity.

Front Hum Neurosci 2020 25;14:61. Epub 2020 Feb 25.

Neurology Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States.

Accurate localization of complex human experiences such as emotions, dreaming, creativity, and consciousness to specific cerebral structures or neural networks has remained elusive despite technological advances. We report the use of acute deep brain stimulation (DBS) to evoke behavioral and emotional effects by applying electrical stimulation (ES) at various voltage strengths to the basolateral and central subnuclei of the amygdala in addition to the head of hippocampus (HC) for two subjects with medically refractory post-traumatic stress disorder (PTSD). Our results suggest that the amygdala could be a node in a neural network responsible for the generation of complex vivid mental imagery and integrated sensory experiences similar to John Hughlings Jackson's "dreamy state" and "double consciousness," which have been classically associated with temporal lobe epilepsy during uncinate seizures. Read More

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http://dx.doi.org/10.3389/fnhum.2020.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052301PMC
February 2020
2.895 Impact Factor

Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.

J Neurol 2020 Mar 4. Epub 2020 Mar 4.

Neuro-Otology Unit, Division of Brain Sciences, Imperial College London, London, UK.

Background: Anti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a longer hospital stay. Read More

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http://dx.doi.org/10.1007/s00415-020-09769-5DOI Listing

Quantitative readability analysis of websites providing information on traumatic brain injury and epilepsy: A need for clear communication.

Epilepsia 2020 Mar 24;61(3):528-538. Epub 2020 Feb 24.

Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience, and Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.

Objective: The use of the Internet for health-related questions is increasing, but it is not clear whether individuals can understand the information available online. Most health organizations recommend that health educational materials (HEMs) be written below the sixth grade reading level. This study was designed to evaluate the readability level of available online HEMs pertaining to traumatic brain injury (TBI), epilepsy, and posttraumatic epilepsy (PTE). Read More

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http://dx.doi.org/10.1111/epi.16446DOI Listing

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury.

J Vis Exp 2020 Feb 10(156). Epub 2020 Feb 10.

Fralin Biomedical Research Institute at Virginia Tech Carilion; School of Neuroscience, Virginia Tech; Department of Biological Sciences, Virginia Tech;

Traumatic brain injury (TBI) is a leading cause of acquired epilepsy. TBI can result in a focal or diffuse brain injury. Focal injury is a result of direct mechanical forces, sometimes penetrating through the cranium, creating a direct lesion in the brain tissue. Read More

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http://dx.doi.org/10.3791/60360DOI Listing
February 2020

Vascular Integrity and Signaling Determining Brain Development, Network Excitability, and Epileptogenesis.

Front Physiol 2019 22;10:1583. Epub 2020 Jan 22.

Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.

Our understanding of the etiological mechanisms leading up to epilepsy has undergone radical changes over time due to more insights into the complexity of the disease. The traditional hypothesis emphasized network hyperexcitability and an imbalance of inhibition and excitation, eventually leading to seizures. In this context, the contribution of the vascular system, and particularly the interactions between blood vessels and neuronal tissue, came into focus only recently. Read More

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http://dx.doi.org/10.3389/fphys.2019.01583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987412PMC
January 2020

Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis.

Ann Neurol 2020 Apr 24;87(4):497-515. Epub 2020 Feb 24.

Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ.

Objective: Traumatic brain injury is a major risk factor for acquired epilepsies, and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling in modifying neuronal excitability and promoting epileptogenesis. Here we examined the effect of innate immune receptor Toll-like receptor 4 (TLR4) on excitability of the hippocampal dentate gyrus and epileptogenesis after brain injury. Read More

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http://dx.doi.org/10.1002/ana.25698DOI Listing

Thrombin as Key Mediator of Seizure Development Following Traumatic Brain Injury.

Front Pharmacol 2019 14;10:1532. Epub 2020 Jan 14.

Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, Israel.

Traumatic brain injury (TBI) commonly leads to development of seizures, accounting for approximately 20% of newly diagnosed epilepsy. Despite the high clinical significance, the mechanisms underlying the development of posttraumatic seizures (PTS) remain unclear, compromising appropriate management of these patients. Accumulating evidence suggest that thrombin, the main serine protease of the coagulation cascade, is involved in PTS genesis by mediating inflammation and hyperexcitability following blood brain barrier breakdown. Read More

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http://dx.doi.org/10.3389/fphar.2019.01532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971217PMC
January 2020

Statistical Guidelines for Handling Missing Data in Traumatic Brain Injury Clinical Research.

J Neurotrauma 2020 Mar 10. Epub 2020 Mar 10.

Brain and Spinal Injury Center (BASIC), Weill Institute for Neurosciences, Department of Neurological Surgery, University of California San Francisco (UCSF), San Francisco, California.

Missing data is a persistent and unavoidable problem in even the most carefully designed traumatic brain injury (TBI) clinical research. Missing data patterns may result from participant dropout, non-compliance, technical issues, or even death. This review describes the types of missing data that are common in TBI research, and assesses the strengths and weaknesses of the statistical approaches used to draw conclusions and make clinical decisions from these data. Read More

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http://dx.doi.org/10.1089/neu.2019.6702DOI Listing

Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing.

J Neurotrauma 2020 Mar;37(5):692-705

Center for Advanced Imaging, University of Queensland, St. Lucia, Queensland, Australia.

Targeting neuroinflammation is a novel frontier in the prevention and treatment of epilepsy. A substantial body of evidence supports a key role for neuroinflammation in epileptogenesis, the pathological process that leads to the development and progression of spontaneous recurrent epileptic seizures. It is also well recognized that traumatic brain injury (TBI) induces a vigorous neuroinflammatory response and that a significant proportion of patients with TBI suffer from debilitating post-traumatic epilepsy. Read More

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http://dx.doi.org/10.1089/neu.2019.6942DOI Listing

Synthesis and Preclinical Evaluation of an F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [F]SynVesT-2.

ACS Chem Neurosci 2020 02 4;11(4):592-603. Epub 2020 Feb 4.

PET Center, Department of Radiology and Biomedical Imaging , Yale University , New Haven , Connecticut 06520 , United States.

Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously expressed in presynaptic vesicles. imaging of SV2A using PET has potential applications in the diagnosis and prognosis of a variety of neuropsychiatric diseases, e.g. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00618DOI Listing
February 2020

Traumatic Dural Venous Sinuses Injury.

Open Access Maced J Med Sci 2019 Oct 15;7(19):3225-3234. Epub 2019 Aug 15.

Department of Neurosurgery, Kasr Alainy Medical School, Cairo University, Cairo, Egypt.

The traumatic dural venous sinus injury is one of the most dangerous complications of TBI, either due to fatal intracranial compressing venous bleeding, or disturbing the intracranial pressure which could be caused by injury to the SSS On the other hand, post traumatic dural sinus thrombosis is considered a rare complication which may lead to hemorrhagic infarction with its serious consequences including epilepsy, neurological deficits, or death. Therefore, knowledge of the appropriate treatment of this kind of head injury is essential. Read More

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http://dx.doi.org/10.3889/oamjms.2019.535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953929PMC
October 2019

Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review.

BMC Psychiatry 2020 Jan 16;20(1):24. Epub 2020 Jan 16.

NICM Health Research Institute, Western Sydney University, Westmead, NSW, 2145, Australia.

Background: Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity, chemotherapy-induced nausea and vomiting, and intractable childhood epilepsy. Yet its potential application in the field of psychiatry is lesser known. Read More

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http://dx.doi.org/10.1186/s12888-019-2409-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966847PMC
January 2020
2.210 Impact Factor

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity.

Epilepsia 2020 Feb 13;61(2):203-215. Epub 2020 Jan 13.

Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia.

Owing to the complexity of the pathophysiological mechanisms driving epileptogenesis following traumatic brain injury (TBI), effective preventive treatment approaches are not yet available for posttraumatic epilepsy (PTE). Neuroinflammation appears to play a critical role in the pathogenesis of the acquired epilepsies, including PTE, but despite a large preclinical literature demonstrating the ability of anti-inflammatory treatments to suppress epileptogenesis and chronic seizures, no anti-inflammatory treatment approaches have been clinically proven to date. TBI triggers robust inflammatory cascades, suggesting that they may be relevant for the pathogenesis of PTE. Read More

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http://dx.doi.org/10.1111/epi.16424DOI Listing
February 2020

Can we predict response to vagus nerve stimulation in intractable epilepsy.

Int J Neurosci 2020 Feb 5:1-8. Epub 2020 Feb 5.

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.

Since vagus nerve stimulation (VNS) was approved by the Food and Drug Administration (FDA). A number of studies show that VNS was effective to reduce seizure frequency. However, there was still some patients treated with VNS having poor or even no clinical effect. Read More

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http://dx.doi.org/10.1080/00207454.2020.1713777DOI Listing
February 2020

Epilepsy over the centuries: a disease survived at the time.

Neurol Sci 2020 May 2;41(5):1309-1313. Epub 2020 Jan 2.

Department of Neurosurgery, University of Catanzaro, Italy, Campus Germaneto, Vle Europa, 88100, Catanzaro, Italy.

In this study, we have made a historical review of epilepsy through the centuries, from pre-Christian era to the present time. The epileptic was examined by Hippocrates, the first to recognize epilepsy as a disease and not as a supernatural manifestation called Morbus Sacer. The dark years of the Middle Ages were the worst for the disease, where the sufferer was even subjected to torture. Read More

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http://dx.doi.org/10.1007/s10072-019-04214-6DOI Listing

Medical Cannabis as a Treatment for Patients With Epilepsy, Sleep Disorders, and Posttraumatic Stress Disorder.

J Clin Neurophysiol 2020 Jan;37(1)

Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://dx.doi.org/10.1097/WNP.0000000000000650DOI Listing
January 2020

Aquaporin-4 Dysregulation in a Controlled Cortical Impact Injury Model of Posttraumatic Epilepsy.

Neuroscience 2020 Jan 19;428:140-153. Epub 2019 Dec 19.

Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA. Electronic address:

Posttraumatic epilepsy (PTE) is a long-term negative consequence of traumatic brain injury (TBI) in which recurrent spontaneous seizures occur after the initial head injury. PTE develops over an undefined period during which circuitry reorganization in the brain causes permanent hyperexcitability. The pathophysiology by which trauma leads to spontaneous seizures is unknown and clinically relevant models of PTE are key to understanding the molecular and cellular mechanisms underlying the development of PTE. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.12.006DOI Listing
January 2020

Animal Models of Post-Traumatic Epilepsy.

Diagnostics (Basel) 2019 Dec 19;10(1). Epub 2019 Dec 19.

Department of Neurosurgery, Neuroscience Institute, Baylor Scott and White Health, Central Division, Temple, TX 76508, USA.

Traumatic brain injury is the leading cause of morbidity and mortality worldwide, with the incidence of post-traumatic epilepsy increasing with the severity of the head injury. Post-traumatic epilepsy (PTE) is defined as a recurrent seizure disorder secondary to trauma to the brain and has been described as one of the most devastating complications associated with TBI (Traumatic Brain Injury). The goal of this review is to characterize current animal models of PTE and provide succinct protocols for the development of each of the currently available animal models. Read More

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http://dx.doi.org/10.3390/diagnostics10010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169449PMC
December 2019

The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities.

Epileptic Disord 2019 12;21(6):529-547

Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.

Psychogenic non-epileptic seizures (PNES), also known as dissociative seizures, are paroxysms of altered subjective experience, involuntary movements and reduced self-control that can resemble epileptic seizures, but have distinct clinical characteristics and a complex neuropsychiatric aetiology. They are common, accounting for over 10% of seizure emergencies and around 30% of cases in tertiary epilepsy units, but the diagnosis is often missed or delayed. The recently proposed "integrative cognitive model" accommodates current research on experiential, psychological and biological risk factors for the development of PNES, but in view of the considerable heterogeneity of presentations and medical context, it is not certain that a universal model can capture the full range of PNES manifestations. Read More

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http://dx.doi.org/10.1684/epd.2019.1107DOI Listing
December 2019

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury.

Neuropharmacology 2019 Dec 6:107907. Epub 2019 Dec 6.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA, 30322, Georgia. Electronic address:

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults worldwide. TBI survival is associated with persistent neuropsychiatric and neurological impairments, including posttraumatic epilepsy (PTE). To date, no pharmaceutical treatment has been found to prevent PTE or ameliorate neurological/neuropsychiatric deficits after TBI. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.107907DOI Listing
December 2019

Role of Astrocytes in Post-traumatic Epilepsy.

Front Neurol 2019 13;10:1149. Epub 2019 Nov 13.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.

Traumatic brain injury, a common cause of acquired epilepsy, is typical to find necrotic cell death within the injury core. The dynamic changes in astrocytes surrounding the injury core contribute to epileptic seizures associated with intense neuronal firing. However, little is known about the molecular mechanisms that activate astrocytes during traumatic brain injury or the effect of functional changes of astrocytes on seizures. Read More

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http://dx.doi.org/10.3389/fneur.2019.01149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863807PMC
November 2019

Cannabinoids: A Guide for Use in the World of Gastrointestinal Disease.

J Clin Gastroenterol 2019 Nov 27. Epub 2019 Nov 27.

Marks Colorectal Surgical Associates, Lankenau Medical Center, Wynnewood, PA.

Cannabinoids have been known as the primary component of cannabis for decades, but the characterization of the endocannabinoid system (ECS) in the 1990s opened the doors for cannabis' use in modern medicine. The 2 main receptors of this system, cannabinoid receptors 1 and 2, are found on cells of various tissues, with significant expression in the gastrointestinal (GI) tract. The characterization of the ECS also heralded the understanding of endocannabinoids, naturally occurring compounds synthesized in the human body. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001287DOI Listing
November 2019

Optimized sampling for high resolution multi-pinhole brain SPECT with stationary detectors.

Phys Med Biol 2020 01 10;65(1):015002. Epub 2020 Jan 10.

Section Biomedical Imaging, Delft University of Technology, Delft, The Netherlands. Author to whom correspondence should be addressed.

Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. Read More

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http://dx.doi.org/10.1088/1361-6560/ab5bc6DOI Listing
January 2020

Moral injury in Veterans with nonepileptic seizures.

Epilepsy Behav 2020 Jan 22;102:106681. Epub 2019 Nov 22.

Providence VA Medical Center, Providence, RI, United States of America; Brown University, Providence, RI, United States of America.

Objective: Over 40% of combat Veterans report exposure to at least one type of morally injurious experience (MIE). While moral injury (MI) is described among Veterans with posttraumatic stress disorder (PTSD), MI has not been studied in Veterans with psychogenic nonepileptic seizures (PNES). We sought to identify MI in a clinical sample of Veterans with PNES and describe differences between those with MI and those without. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106681DOI Listing
January 2020

Auricular Electroacupuncture for Late Posttraumatic Epilepsy after Severe Brain Injury: A Retrospective Study.

Evid Based Complement Alternat Med 2019 13;2019:5798912. Epub 2019 Oct 13.

School of Acupuncture and Chinese Tuina, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.

Background: Posttraumatic epilepsy (PTE) is a common complication of traumatic brain injury (TBI), which seriously affects patients' survival and recovery. Vagus nerve stimulation (VNS) is a nonpharmacological therapy for epilepsy. The auricular branch of the vagus nerve (ABVN) is the only peripheral branch and has antiepileptic effects, but the efficacy of ABVN stimulation as treatment of late PTE is uncertain. Read More

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http://dx.doi.org/10.1155/2019/5798912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815526PMC
October 2019

Cognitive-emotion processing in psychogenic nonepileptic seizures.

Epilepsy Behav 2020 Jan 12;102:106639. Epub 2019 Nov 12.

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address:

Background: Previous literature suggests that cognitive-emotion processing contributes to the pathogenesis of psychogenic nonepileptic seizures (PNES). Characterization of alterations in cognitive-emotion processing in PNES could inform treatment.

Methods: In this descriptive, cross-sectional study, 143 patients with video electroencephalogram (EEG) confirmed PNES were prospectively recruited. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106639DOI Listing
January 2020

Seizure Prophylaxis in Traumatic Brain Injury: A Comparative Study of Levetiracetam and Phenytoin Cerebrospinal Fluid Levels in Trauma Patients with Signs of Increased Intracranial Pressure Requiring Ventriculostomy.

Cureus 2019 Sep 27;11(9):e5784. Epub 2019 Sep 27.

Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA.

Background One of the most common life-threatening injuries to trauma patients arriving in the emergency department (ED) is traumatic brain injury (TBI). Traditionally, intravenous medications have been given as seizure prophylaxis in patients demonstrating signs of increased intracranial pressure (ICP), as post-traumatic seizures in trauma patients are associated with higher morbidity and mortality. Medications traditionally given for this indication such as phenytoin have been established to reach therapeutic levels in the cerebrospinal fluid (CSF) quickly and are effective in preventing post-traumatic seizures but often have a large side-effect profile. Read More

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http://dx.doi.org/10.7759/cureus.5784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825487PMC
September 2019

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets.

Brain Sci 2019 Nov 9;9(11). Epub 2019 Nov 9.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.

Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug-resistant in at least one-third of patients, there is a clear need for novel therapeutic strategies to prevent epilepsy from developing after TBI, or to mitigate its severity. It has long been recognized that seizure activity is associated with a local immune response, characterized by the activation of microglia and astrocytes and the release of a plethora of pro-inflammatory cytokines and chemokines. Read More

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http://dx.doi.org/10.3390/brainsci9110318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895909PMC
November 2019

The Positive Allosteric Modulator of 2/3-Containing GABA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.

J Pharmacol Exp Ther 2020 Jan 6;372(1):83-94. Epub 2019 Nov 6.

Department of Neurologic Surgery, Indiana University School of Medicine, Indianapolis, Indiana (W.X., X.P., R.C., X.J.); Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin (J.M.W., G.L., L.K.G., F.R., R.J., J.M.C.); Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana (W.X., X.P., X.J.); and Laboratory of Antiepileptic Drug Discovery, St. Vincent's Hospital, Indianapolis, Indiana (J.L.S.)

The imidizodiazepine, 5-(8-ethynyl-6-(pyridin-2-yl)-4-benzo[]imidazo[1,5-][1,4]diazepin-3-yl)oxazole (KRM-II-81), is selective for 2/3-containing GABA receptors. KRM-II-81 dampens seizure activity in rodent models with enhanced efficacy and reduced motor-impairment compared with diazepam. In the present study, KRM-II-81 was studied in assays designed to detect antiepileptics with improved chances of impacting pharmaco-resistant epilepsies. Read More

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http://dx.doi.org/10.1124/jpet.119.260968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927408PMC
January 2020

Psychiatric aspects of posttraumatic epilepsy: A still unexplored area.

Authors:
Marco Mula

Epilepsy Behav 2019 12 31;101(Pt A):106598. Epub 2019 Oct 31.

Institute of Medical and Biomedical Education, St George's University of London, London, United Kingdom; Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address:

Traumatic brain injury (TBI) represents one of the most common causes of death and disability in young people, and posttraumatic epilepsy (PTE) accounts for 10% to 20% of all symptomatic epilepsies. However, PTE is still a relatively underappreciated condition. This paper aimed at reviewing current knowledge about psychiatric comorbidities of PTE, looking in particular at the nature of the relationship between TBI, psychiatric problems, and epilepsy, at the phenomenology of psychiatric disorders in PTE, and how to manage them. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.106598DOI Listing
December 2019

Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury.

J Alzheimers Dis 2019 ;72(3):683-691

Department of Pathology, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

Traumatic brain injury (TBI) is widely assumed to be causal in neurodegenerative disease, based on epidemiological surveys demonstrating an increased risk of Alzheimer disease (AD) following TBI, and on recent theories surrounding repetitive head movement. We tested this assumption by evaluating 30 consecutive forensic examinations in which neuropathology consultation was sought, and in which a history of remote TBI was uncovered during the course of the investigation. In this series, there was a high frequency of psychiatric co-morbidities (100%), remote contusion (90%), and seizures (63%). Read More

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http://dx.doi.org/10.3233/JAD-190782DOI Listing
January 2019
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Imaging biomarkers of posttraumatic epileptogenesis.

Epilepsia 2019 11 8;60(11):2151-2162. Epub 2019 Oct 8.

Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.

Traumatic brain injury (TBI) affects 2.5 million people annually within the United States alone, with over 300 000 severe injuries resulting in emergency room visits and hospital admissions. Severe TBI can result in long-term disability. Read More

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http://dx.doi.org/10.1111/epi.16357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842410PMC
November 2019
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