Search Our Scientific Publications & Authors

Biomed Pharmacother 2022 Jun 25;150:113017. Epub 2022 Apr 25.

Department of Vascular Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Electronic address:

The recurrence of cancer after local surgery has been a difficult problem in the clinic for a long time. In recent years, local treatment via drug-loaded thermosensitive hydrogels have become a promising strategy to prevent cancer recurrence. Thus, a thermosensitive hydrogel based on poloxamer 407, poloxamer 188 and the bioadhesive excipient carbomer 974P was designed to locally release paclitaxel and prevent local tumour recurrence after direct smearing of the hydrogel at the site of injury in the surgical cavity. Read More

J Surg Oncol 2022 Jun 1;125(8):1218-1223. Epub 2022 Mar 1.

Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Background And Objectives: Given the significant benefit of targeted therapies for HER2+ breast cancer patients in both the neoadjuvant and adjuvant settings, it is critical to identify all eligible patients for these treatments. We sought to investigate cT1cN0 HER2+ patients to determine the rate of postsurgical nodal positivity, and to identify presurgical factors associated with nodal positivity. We hypothesize there is a subset of underdiagnosed HER2+ patients who would benefit from preoperative axillary imaging and inclusion in neoadjuvant chemotherapy regimens. Read More

Radiol Case Rep 2022 Apr 3;17(4):1041-1043. Epub 2022 Feb 3.

Johns Hopkins Hospital, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA.

Primary osteosarcomas of the heart are extremely rare entities, with common subtypes including osteoblastic, chondroblastic and fibroblastic subtypes. We describe a case of a 53-year-old female with history of treated breast cancer who presented with progressive dyspnea on exertion. A pulmonary artery protocol CTA demonstrated an anterior mitral leaflet lobulated mass without an osteoid or chondroid matrix. Read More

Cancer 2022 Feb 18;128(4):708-718. Epub 2021 Oct 18.

Department of Thoracic Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Background: Circulating tumor DNA (ctDNA) has emerged as a noninvasive biomarker for dynamically monitoring tumors. However, published data on perioperative ctDNA in patients with operable non-small cell lung cancer (NSCLC) are currently limited.

Methods: This prospective study recruited 123 patients with resectable stage I to IIIA NSCLC. Read More

Dermatol Surg 2021 12;47(12):1573-1578

Plastic Surgery Center, Pakkred, Nonthaburi, Thailand.

Background: Botulinum toxin A benefits postsurgical scar prevention by reducing wound edge tension and inhibiting in vitro scar tissue fibrosis.

Objective: To investigate the efficacy of botulinum toxin Type A (BTX) in improving inframammary scar appearance after primary breast augmentation.

Materials And Methods: A prospective, double-blinded, randomized controlled trial was performed with 27 participants receiving primary augmentation mammoplasty with inframammary incisions. Read More

Tumori 2021 Oct 9:3008916211050124. Epub 2021 Oct 9.

Breast Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy.

Purpose: To compare the reproducibility between contrast-enhanced digital mammography (CEDM) and magnetic resonance imaging (MRI) with the postsurgical pathologic examination. In addition, the applicability of the Breast Imaging-Reporting and Data System (BI-RADS) lexicon of MRI to CEDM was evaluated for mass lesions.

Methods: A total of 62 patients with a histologically proven diagnosis of breast cancer were included in this study, for a total of 67 lesions. Read More

J Am Coll Radiol 2021 11 6;18(11):1540-1546. Epub 2021 Aug 6.

Johns Hopkins Medicine, Baltimore, Maryland. Electronic address:

Objective: Currently, national and international breast imaging practices utilize variable postsurgical surveillance protocols without uniform recommendations. Because of the innate differences between screening versus diagnostic mammography from scheduling flexibility to out-of-pocket costs, this creates the opportunity for lapses in patient adherence, which has the potential to impact clinical outcomes. The purpose of this study is to evaluate the relationship between sociodemographic factors and postsurgical surveillance imaging protocols on patient adherence rates. Read More

Eur J Breast Health 2021 Jul 24;17(3):206-213. Epub 2021 Jun 24.

Department of Radiology, UT Southwestern Medical Center, Texas, USA.

Reduction mammoplasty is a common surgical procedure that removes a significant portion of the breast, and the resulting changes to the breast parenchyma are frequently seen on breast imaging studies. Any radiologist who interprets breast imaging studies must be able to recognize these changes in order to avoid unnecessary recall from screening and/or breast biopsy. The surgical techniques used in reduction mammoplasty are discussed in order to provide relevant background information for understanding the resulting imaging features. Read More

Mol Imaging Radionucl Ther 2021 06;30(2):110-112

Las Américas Clinic Auna, Department of Radiology, Medellin, Antioquia, Colombia

Li-Fraumeni syndrome is a rare disorder caused by abnormalities of the tumor-suppressor protein gene. We present the case of a 26-years-old female diagnosed with bilateral ductal carcinoma. The genetic panel for breast cancer gene 1 (BRCA1) and BRCA2 mutations was negative and positive heterozygous germline tumor protein gene mutations, considering Li-Fraumeni syndrome. Read More

Gland Surg 2021 Apr;10(4):1515-1522

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Hematomas represent one of the postoperative complications in patients undergoing reconstructive or aesthetic breast surgery with a silicone implant. Although there are few reports of intracapsular hematoma, those presenting late hematoma after reconstructive and aesthetic augmentation surgeries are rarer. This study reported two Asian patients with late hematoma after reconstruction and aesthetic breast surgery. Read More

Breast J 2021 07 3;27(7):608-611. Epub 2021 Apr 3.

Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Reflector-guided localization uses a nonradioactive radar implant for wire-free presurgical breast lesion localization. A single-institution retrospective evaluation found lower rates of positive margins and of close margins for reflector-guided localizations compared with wire localizations, resulting in a statistically significant decrease in the re-excision rates (p = 0.015). Read More

Radiology 2021 03;298(3):713-716

From the Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, 1653 W Congress Pkwy, Jelke 181, Chicago, IL 60612.

History A 60-year-old woman was diagnosed with a new right upper lobe stage I lung adenocarcinoma and underwent video-assisted thoracoscopic surgery (VATS) for right upper lobectomy. Her postoperative course was complicated by a large pneumothorax after chest tube removal on postoperative day 3. This was managed with repeat right-sided chest tube placement on the same day. Read More

J Breast Imaging 2020 Jun 23;2(3):250-258. Epub 2020 Apr 23.

Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY.

Objective: Preoperative MRI-guided wire localization (MWL) presents challenges to both the physician and patient. In this study, we examined the efficiency and outcome of MRI-guided marker placement followed by mammographic-guided radioactive seed localization (MMP/RSL) as an alternative localization method. The primary outcome parameter was pathology upon excision. Read More

J Cardiothorac Vasc Anesth 2021 Jun 16;35(6):1594-1602. Epub 2020 Nov 16.

Department of Anesthesia and Cardiac Surgery Intensive Care Unit, San Michele Hospital, Maddaloni, Caserta, Italy.

Fascial plane chest wall blocks are an integral component to optimal multimodal postoperative analgesia in breast and cardiothoracic surgery, facilitating faster functional recovery and earlier discharge. Pectoral nerves block and serratus plane block have been used to treat postsurgical pain after breast and cardiothoracic surgeries; however, they cannot be used to anesthetize the anterior chest wall. Ultrasound parasternal block, or pectointercostal fascial block and transversus thoracis muscle plane block are two novel ultrasound-guided anesthetic and analgesic techniques that block the anterior cutaneous branches T2 to T6 intercostal nerves, providing anesthesia and analgesia to the anterior chest wall. Read More

Radiol Case Rep 2021 Jan 29;16(1):40-46. Epub 2020 Oct 29.

Department of Breast Imaging, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, CPB5.3201, Houston, TX 77030, USA.

Autologous flap reconstruction is widely used after skin sparing mastectomy to reconstruct the appearance of the breast. We present 2 cases of breast cancer recurrence in a deep inferior epigastric perforator reconstruction, including a 65-year-old female with history of papillary carcinoma and a 35-year-old female with history of a high grade invasive ductal carcinoma with extensive ductal carcinoma in situ. Differential imaging considerations of the post mastectomy patient are reviewed. Read More

Clin Plast Surg 2020 Oct;47(4):649-661

Department of Plastic Surgery, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 89, Barcelona 08026, Spain.

Several methods can be used for identifying tissues for transfer in donor-site-depleted patients. A fillet flap can be temporarily stored in other parts of the body and transferred back to the site of tissue defect, including covering the amputated stump of the lower extremity. Human arm transplant is rare and has some unique concerns for the surgery and postsurgical treatment. Read More

Radiol Case Rep 2020 Oct 12;15(10):1875-1878. Epub 2020 Aug 12.

SUNY Upstate Medical University, Department of Radiology, 750 E. Adams Street, Syracuse, NY 13210, USA.

Hyperdensity within the small bowel is most commonly seen with positive oral contrast agents, intraluminal hemorrhage and less likely an abnormal fistulous connection with the colon containing rectally administered contrast. We present the case of a 57-year-old female with a complex history of breast cancer and multiple abdominal surgeries presenting with intraluminal hyperdense small bowel on computed tomography (CT) performed with rectal contrast. Postsurgical CT with rectal contrast, and no oral contrast, showed multifocal regions of intraluminal hyperdensity with the small bowel anterior to and close to the surgical anastomosis. Read More

Breast J 2020 07 16;26(7):1375-1378. Epub 2020 Apr 16.

Breast Unit, Breast Imaging Department of Radiology, University Hospital of Parma, Parma, Italy.

Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. PDST is distinguished from phyllodes tumor by its lack of leaf-like architecture; however, it is still unclear whether PDST is a separate entity or a certain spectrum of phyllodes tumor. Read More

ACS Sens 2020 03 6;5(3):711-718. Epub 2020 Mar 6.

Department of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.

A luminescent spectral ruler was developed to measure micrometer to millimeter displacements through tissue. The spectral ruler has two components: a luminescent encoder patterned with alternating stripes of two spectrally distinct luminescent materials and an analyzer mask with periodic transparent windows the same width as the encoder stripes. The analyzer mask is placed over the encoder and held so that only one type of luminescent stripe is visible through the window; sliding the analyzer over the encoder modulates the luminescence spectrum acquired through the analyzer windows, enabling detection of small displacements without imaging. Read More

Radiologia (Engl Ed) 2020 Sep - Oct;62(5):365-375. Epub 2020 Feb 21.

Sección de Radiología Mamaria, Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, España.

Objective: Triple-negative tumors are the most aggressive type of breast cancer. We aimed to analyze the main radiologic and histopathologic factors of these tumors to create a risk profile.

Materials And Methods: We analyzed data from 140 patients diagnosed with triple-negative breast cancer between January 2007 and December 2016, with follow-up through April 2018. Read More

BMC Cancer 2019 Dec 10;19(1):1201. Epub 2019 Dec 10.

Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, Seoul, 03181, South Korea.

Background: In patients diagnosed with ductal carcinoma in situ (DCIS) with needle biopsy before surgery, invasive component (IC) is often found in the postoperative tissue, which results in altered post-surgical care. However, there are no clinically available factors to predict IC, and few MRI studies are available for the detection of IC in DCIS patients. The purpose of this study was to evaluate which risk factors can predict IC preoperatively. Read More

Mol Cancer Ther 2020 03 3;19(3):802-811. Epub 2019 Dec 3.

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Postoperative tumor recurrence and metastasis remain an extreme challenge in breast cancer. Therapies that target cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have provided unprecedented clinical benefits in various types of cancer. The aim of this study was to determine whether the combination of anti-CTLA-4 and anti-PD-1 could prevent postoperative breast tumor recurrence and metastasis in breast tumor-bearing mice. Read More

J Evid Based Med 2019 Aug;12(3):209-217

Veritas Health Sciences Consultancy, Bridgewater, New Jersey.

Aims: Breast cancer within the region continues to present challenges to the healthcare services. Strategies to shed light on clinical gaps could better support country-specific circumstances. The aims of the mapping study were to identify the gaps in the evidence base, for the management of breast cancer with relevance to Bahrain and the Gulf Region. Read More

Int J Surg Oncol 2019 16;2019:7437324. Epub 2019 Jun 16.

Department of Plastic and Reconstructive Surgery, "Sapienza" University of Rome, V.le Regina Elena 324, 00161 Rome, Italy.

Mastectomy and breast prosthetic reconstruction is the most common surgical treatment for women diagnosed with breast cancer. In the last few years, breast prosthetic augmentation in acellular dermal matrix (ADM) has been introduced. The aim of this study is to present our single-center experience in evaluating the outcome of patients who underwent breast reconstruction in ADM, using ultrasound (US) examination. Read More

World Neurosurg 2019 Jul 4;127:186-193. Epub 2019 Apr 4.

Division of Oncological Surgery, Department of Surgery, College of Medicine, University of Ibadan/University College Hospital Ibadan, Ibadan, Nigeria.

Background: Brain metastasis (BM) from breast cancer is increasingly encountered clinically because of the continuing success in the oncological control of the primary disease. Data-driven reports on the surgical treatment of BM from breast cancer are sparse in sub-Saharan Africa.

Methods: This is a prospective cohort study of the outcome of surgical excision of BM from breast cancer in an academic surgical practice in Ibadan, Nigeria. Read More

J Med Imaging Radiat Sci 2018 Jun 10;49(2):173-178. Epub 2018 Apr 10.

Associate Professor, Deputy Head of School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

Introduction: Computed tomography (CT) simulation is currently used to identify the tumour bed in patients with early stage breast cancer requiring whole-breast and boost radiation therapy. Postlumpectomy breast seromas as visible on CT data have been identified as a proxy for the tumour bed. This study aims to quantify the incidence of postsurgical tumour bed seromas identified at CT simulation and report how well a radiation therapist (RT) is able to identify these seromas compared with those contoured by radiation oncologists (ROs). Read More

Clin Cancer Res 2018 08 30;24(15):3572-3582. Epub 2018 Apr 30.

Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, California.

Breast cancer often requires surgical treatment including breast-conserving surgical resection. However, with current postsurgical histologic margin analysis, one quarter of breast cancer patients undergo reexcision to achieve negative margins corresponding to decreased local recurrence and better outcomes. Therefore, a method with high resolution and specificity for intraoperative margin assessment is needed. Read More

Int J Nanomedicine 2017 21;12:8337-8351. Epub 2017 Nov 21.

CAS Key Laboratory of Molecular Imaging.

An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutic effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. Read More

J Ultrasound Med 2018 Jun 20;37(6):1447-1453. Epub 2017 Nov 20.

Breast Center, University Hospital of Llandough, Penarth, Wales.

Objectives: The low sensitivity of ultrasonography (US) for diagnosing axillary lymph node metastasis in patients with breast cancer has led to the development of multiple tools in an attempt to increase preoperative sensitivity, including second-look US. We compared axillary lymph node metastasis predictor scores with postsurgical findings, using the Memorial Sloan Kettering Cancer Center (MSKCC; New York, NY) and Evidencio (www.evidencio. Read More

Breast Care (Basel) 2017 Sep 10;12(4):260-265. Epub 2017 Aug 10.

Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Rome, Italy.

Breast-oncoplastic surgery, allowing local tumor control and a better cosmetic outcome, is oncologically safe when applied to early-stage breast cancer. Breast cancer recurrence following conservative therapy may occur during the first 5 years after treatment, with a peak incidence after 2 years. Therefore, during the follow-up period, patients undergo a series of ultrasound (US) and mammographic examinations. Read More