93 results match your criteria Postsurgical Breast Imaging


Intraoperative Resection Guidance with Photoacoustic and Fluorescence Molecular Imaging Using an Anti-B7-H3 Antibody-Indocyanine Green Dual Contrast Agent.

Clin Cancer Res 2018 Aug 30;24(15):3572-3582. Epub 2018 Apr 30.

Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, California.

Breast cancer often requires surgical treatment including breast-conserving surgical resection. However, with current postsurgical histologic margin analysis, one quarter of breast cancer patients undergo reexcision to achieve negative margins corresponding to decreased local recurrence and better outcomes. Therefore, a method with high resolution and specificity for intraoperative margin assessment is needed. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102723PMC
August 2018
2 Reads

Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model.

Int J Nanomedicine 2017 21;12:8337-8351. Epub 2017 Nov 21.

CAS Key Laboratory of Molecular Imaging.

An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutic effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. Read More

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http://dx.doi.org/10.2147/IJN.S149235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701610PMC
April 2018
34 Reads
1 Citation

Can Nomograms Predict Preoperative Axillary Lymph Node Metastasis in Patients With Breast Cancer to Guide Second Look Ultrasonography?

J Ultrasound Med 2018 Jun 20;37(6):1447-1453. Epub 2017 Nov 20.

Breast Center, University Hospital of Llandough, Penarth, Wales.

Objectives: The low sensitivity of ultrasonography (US) for diagnosing axillary lymph node metastasis in patients with breast cancer has led to the development of multiple tools in an attempt to increase preoperative sensitivity, including second-look US. We compared axillary lymph node metastasis predictor scores with postsurgical findings, using the Memorial Sloan Kettering Cancer Center (MSKCC; New York, NY) and Evidencio (www.evidencio. Read More

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http://dx.doi.org/10.1002/jum.14485DOI Listing
June 2018
2 Reads

Magnetic Resonance Imaging after Breast Oncoplastic Surgery: An Update.

Breast Care (Basel) 2017 Sep 10;12(4):260-265. Epub 2017 Aug 10.

Department of Radiology, Anatomo-Pathology and Oncology, Sapienza University of Rome, Rome, Italy.

Breast-oncoplastic surgery, allowing local tumor control and a better cosmetic outcome, is oncologically safe when applied to early-stage breast cancer. Breast cancer recurrence following conservative therapy may occur during the first 5 years after treatment, with a peak incidence after 2 years. Therefore, during the follow-up period, patients undergo a series of ultrasound (US) and mammographic examinations. Read More

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http://dx.doi.org/10.1159/000477896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649274PMC
September 2017
20 Reads

Variability of Postsurgical Imaging Surveillance of Breast Cancer Patients: A Nationwide Survey Study.

AJR Am J Roentgenol 2018 Jan 24;210(1):222-227. Epub 2017 Oct 24.

5 Department of Radiology, Emory University, Atlanta, GA.

Objective: Because of observed clinical variance and the discretion of referring physicians and radiologists in patient follow-up, the purpose of this study was to conduct a survey to explore whether broad discrepancy exists in imaging protocols used for postsurgical surveillance.

Subjects And Methods: An online survey was created to assess radiologists' use of diagnostic versus screening mammography for women with a personal history of breast cancer and determine whether the choice of protocol was associated with practice characteristics (setting, region, and reader type).

Results: Of 8170 surveys sent, 849 (10%) completed responses were returned. Read More

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http://dx.doi.org/10.2214/AJR.17.17923DOI Listing
January 2018
5 Reads

Diagnostic Challenges of Postsurgical Breast Cancer Recurrence.

Radiol Technol 2017 09;89(1):92-94

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September 2017
1 Read

Primary neuroendocrine carcinoma of the breast - a report of four cases.

Endokrynol Pol 2017 7;68(5):597-602. Epub 2017 Sep 7.

Zakład Medycyny Nuklearnej i Diagnostyki Obrazowej Katedry Radiologii i Medycyny Nuklearnej SUM.

Breast neuroendocrine tumours are rare, accounting for up to 5% of all breasts tumours and approximately 1% of all neuroendocrine tumours. In most cases, breast neuroendocrine tumours are histologically and moderately well differentiated. Neuroendocrine breast tumours lack characteristic imaging patterns. Read More

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http://dx.doi.org/10.5603/EP.a2017.0049DOI Listing
September 2017
9 Reads

Revisiting Nonmass Enhancement in Breast MRI: Analysis of Outcomes and Follow-Up Using the Updated BI-RADS Atlas.

AJR Am J Roentgenol 2017 Nov 23;209(5):1178-1184. Epub 2017 Aug 23.

1 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.

Objective: The purpose of this study is to assess the frequency of reclassification of nonmass enhancement (NME) as background parenchymal enhancement (BPE) and to determine positive predictive values (PPVs) of NME descriptors using the revised BI-RADS atlas.

Materials And Methods: A retrospective review of our institution's MRI database from January 1, 2009, through March 30, 2012, identified 6220 contrast-enhanced breast MRI examinations. All findings prospectively assessed as NME and rated as BI-RADS categories 3, 4, and 5 (n = 386) were rereviewed in consensus by two radiologists who were blinded to pathologic findings with the fifth edition of the BI-RADS lexicon. Read More

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http://dx.doi.org/10.2214/AJR.17.18086DOI Listing
November 2017
28 Reads

Pros and cons of immediate Vicryl mesh insertion after lumpectomy.

Asian J Surg 2018 Nov 18;41(6):537-542. Epub 2017 Aug 18.

Department of Breast Surgery, Shiga Medical Center for Adults, 5-4-30, Moriyama, Shiga, Japan.

Background: Lumpectomy is a standard surgery for breast cancer; however, it results in breast deformity, especially after radiation therapy. Wider surgical margin correlates lower local recurrence rate. However, bigger defect brings worse cosmetic outcome. Read More

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http://dx.doi.org/10.1016/j.asjsur.2017.08.001DOI Listing
November 2018
8 Reads

Case 242: Radiation-induced Angiosarcoma.

Radiology 2017 06;283(3):909-916

From the Department of Diagnostic Radiology, Michigan State University/Beaumont Hospital-Dearborn, 18101 Oakwood Blvd, Dearborn, MI 48183 (M.D.); Knoxville Comprehensive Breast Center, Knoxville, Tenn (K.F.K.); and Drs. Harris, Birkhill, Wang, Songe and Associates, Beaumont Breast Care Center-Wayne, Wayne, Mich (J.M.K.).

History In 2004, this woman received a diagnosis of invasive mammillary carcinoma, tubular variant, strongly positive for estrogen and progesterone receptors. Her lesion was found at screening mammography performed at an outside institution when she was 59 years old. She underwent partial mastectomy, with partial axillary node dissection and sentinel node mapping. Read More

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http://dx.doi.org/10.1148/radiol.2017150456DOI Listing
June 2017
28 Reads

Unique Techniques or Approaches in Microvascular and Microlymphatic Surgery.

Clin Plast Surg 2017 Apr 9;44(2):403-414. Epub 2017 Feb 9.

Department of Plastic Surgery, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 89, Barcelona 08026, Spain.

Several methods can be used for identifying tissues for transfer in donor-site-depleted patients. A fillet flap can be temporarily stored in other parts of the body and transferred back to the site of tissue defect, including covering the amputated stump of the lower extremity. Human arm transplant is rare and has some unique concerns for the surgery and postsurgical treatment. Read More

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http://dx.doi.org/10.1016/j.cps.2016.11.007DOI Listing
April 2017
48 Reads

Use of Poly-4-Hydroxybutyrate Mesh to Optimize Soft-Tissue Support in Mastopexy: A Single-Site Study.

Plast Reconstr Surg 2017 Jan;139(1):67-75

Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical Center.

Background: The ptotic breast is surgically rejuvenated through a mastopexy procedure. Recurrent ptosis or other negative changes to the breast shape are not uncommon following mastopexy, as the tissue laxity and skin quality that contributed to ptosis are not surgically corrected. The purpose of this study was to assess the postsurgical changes in the breasts of patients who underwent a primary mastopexy procedure with soft-tissue reinforcement using a long-term poly-4-hydroxybutyrate resorbable scaffold (i. Read More

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http://dx.doi.org/10.1097/PRS.0000000000002922DOI Listing
January 2017
3 Reads

Analysis of the variability among radiation oncologists in delineation of the postsurgical tumor bed based on 4D-CT.

Oncotarget 2016 Oct;7(43):70516-70523

Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China, 250117.

Objective: This study investigated interobserver and intraobserver variability in radiation oncologists' definition of the tumor bed (TB) after breast-conserving surgery (BCS).

Results: The TB volume, CVS and number of surgical clips were not significantly related to intraobserver variability. Moreover, no correlation was noted between CT slice thickness and interobserver variability (Δinter, DSCinter) in TB delineation, and no significant difference was noted among the three groups. Read More

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http://dx.doi.org/10.18632/oncotarget.12044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342570PMC
October 2016
16 Reads

The Relationship Between Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor 2 Expression of Breast Cancer and the Retention Index in Dual Phase (18)F-FDG PET/CT.

Nucl Med Mol Imaging 2016 Sep 11;50(3):246-54. Epub 2016 Apr 11.

Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), 75, Nowon-ro, Nowon-gu, Seoul, 139-706 Republic of Korea.

Purpose: This study investigates the correlation of retention index (RI) using the dual phase FDG PET/CT scan with the breast cancer biomarkers.

Methods: A total of 55 patients with breast cancer underwent dual phase FDG PET/CT scans (60 and 120 min after FDG injection) before treatment. SUVmax and SUVmean of the primary breast tumors were measured, then the percent change of SUVmax and SUVmean between the two scans were calculated, and denoted as RImax and RImean, respectively. Read More

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http://dx.doi.org/10.1007/s13139-016-0412-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977256PMC
September 2016
44 Reads

Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study.

Cancer Res 2016 09 27;76(18):5512-22. Epub 2016 Jul 27.

Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany.

Differential diagnosis and therapy of heterogeneous breast tumors poses a major clinical challenge. To address the need for a comprehensive, noninvasive strategy to define the molecular and functional profiles of tumors in vivo, we investigated a novel combination of metabolic PET and diffusion-weighted (DW)-MRI in the polyoma virus middle T antigen transgenic mouse model of breast cancer. The implementation of a voxelwise analysis for the clustering of intra- and intertumoral heterogeneity in this model resulted in a multiparametric profile based on [(18)F]Fluorodeoxyglucose ([(18)F]FDG)-PET and DW-MRI, which identified three distinct tumor phenotypes in vivo, including solid acinar, and solid nodular malignancies as well as cystic hyperplasia. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414858PMC
September 2016
19 Reads

Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study of 316 Cases.

Clin Breast Cancer 2016 12 14;16(6):507-513. Epub 2016 Jun 14.

Allina Health Laboratories, Hospital Pathology Associates HPA, Minneapolis, MN.

Background: Management recommendations for lobular neoplasia (LN) including lobular carcinoma-in-situ (LCIS) and atypical lobular hyperplasia (ALH) diagnosed in core biopsies (CB) are controversial. Our aim was to prospectively identify a subset of patients who do not require subsequent surgical excision (SE).

Patients And Methods: All patients diagnosed with LN on CB were enrolled and referred for SE. Read More

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http://dx.doi.org/10.1016/j.clbc.2016.06.003DOI Listing
December 2016
13 Reads

Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results.

Radiology 2016 Dec 22;281(3):720-729. Epub 2016 Jun 22.

From the Departments of Breast Imaging (E.C.G.), Radiology (J.J., D.M.R., F.A.J.), and Surgery (D.L.C., M.A.M., M.G.), Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.

Purpose To use intraoperative supine magnetic resonance (MR) imaging to quantify breast tumor deformation and displacement secondary to the change in patient positioning from imaging (prone) to surgery (supine) and to evaluate residual tumor immediately after breast-conserving surgery (BCS). Materials and Methods Fifteen women gave informed written consent to participate in this prospective HIPAA-compliant, institutional review board-approved study between April 2012 and November 2014. Twelve patients underwent lumpectomy and postsurgical intraoperative supine MR imaging. Read More

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http://dx.doi.org/10.1148/radiol.2016151472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118055PMC
December 2016
3 Reads

Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer.

Cancer Res 2016 08 20;76(15):4493-503. Epub 2016 Jun 20.

Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

VEGF pathway-targeting antiangiogenic drugs, such as bevacizumab, when combined with chemotherapy have changed clinical practice for the treatment of a broad spectrum of human cancers. However, adaptive resistance often develops, and one major mechanism is elevated tumor hypoxia and upregulated hypoxia-inducible factor-1α (HIF1α) caused by antiangiogenic treatment. Reduced tumor vessel numbers and function following antiangiogenic therapy may also affect intratumoral delivery of concurrently administered chemotherapy. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3435DOI Listing
August 2016
22 Reads

Tumor characterization and treatment monitoring of postsurgical human breast specimens using harmonic motion imaging (HMI).

Breast Cancer Res 2016 05 9;18(1):46. Epub 2016 May 9.

Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, New York, NY, USA.

Background: High-intensity focused ultrasound (HIFU) is a noninvasive technique used in the treatment of early-stage breast cancer and benign tumors. To facilitate its translation to the clinic, there is a need for a simple, cost-effective device that can reliably monitor HIFU treatment. We have developed harmonic motion imaging (HMI), which can be used seamlessly in conjunction with HIFU for tumor ablation monitoring, namely harmonic motion imaging for focused ultrasound (HMIFU). Read More

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http://dx.doi.org/10.1186/s13058-016-0707-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862222PMC
May 2016
10 Reads
3 Citations

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions.

Med Phys 2016 May;43(5):2508

Department of Medical Physics, Sunnybrook Odette Cancer Centre, Toronto, Ontario M4N 3M5, Canada and Department of Radiation Oncology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

Purpose: To develop a multipurpose gel-based breast phantom consisting of a simulated tumor with realistic imaging properties in CT, ultrasound and MRI, or a postsurgical cavity on CT. Applications for the phantom include: deformable image registration (DIR) quality assurance (QA), autosegmentation validation, and localization testing and training for minimally invasive image-guided procedures such as those involving catheter or needle insertion.

Methods: A thermoplastic mask of a typical breast patient lying supine was generated and then filled to make an array of phantoms. Read More

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http://dx.doi.org/10.1118/1.4947124DOI Listing
May 2016
10 Reads

Reduction Mammaplasty and Breast Cancer Screening.

Clin Plast Surg 2016 Apr 3;43(2):333-9. Epub 2016 Feb 3.

Division of Plastic and Reconstructive Surgery, Emory University, 550 Peachtree Street, Suite 84300, Atlanta, GA 30308, USA. Electronic address:

Breast reduction surgery is one of the most popular procedures performed by plastic surgeons; based on the current literature, it is safe and does not have a negative impact on identifying breast cancer in women. There are no evidence-based data to confirm the utility of unique screening protocols for women planning to undergo reduction surgery or for those who already had reduction. Women undergoing this surgery should not deviate from the current recommendations of screening mammography in women older than 40 years of average risk. Read More

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http://dx.doi.org/10.1016/j.cps.2015.12.009DOI Listing
April 2016
19 Reads

Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies.

Front Oncol 2016 28;6:17. Epub 2016 Jan 28.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Faculty of Medicine, K. G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development of novel treatment strategies. However, generation of high-quality data requires that sample handling from surgical resection until analysis is performed using systematically validated procedures. In this study, we investigated the effect of postsurgical freezing delay time on global metabolic profiles and stability of individual metabolites in intact tumor tissue. Read More

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http://dx.doi.org/10.3389/fonc.2016.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730796PMC
February 2016
13 Reads

Reproducible Volume Restoration and Efficient Long-term Volume Retention after Point-of-care Standardized Cell-enhanced Fat Grafting in Breast Surgery.

Plast Reconstr Surg Glob Open 2015 Oct 23;3(10):e547. Epub 2015 Oct 23.

Stem Center, Palma de Mallorca, Spain; University of Florida, Gainesville, Fla.; and University of the Balearic Isles, Alimentómica, Palma de Mallorca, Spain.

Unlabelled: Lipoaspirated fat grafts are used to reconstruct volume defects in breast surgery. Although intraoperative treatment decisions are influenced by volume changes observed immediately after grafting, clinical effect and patient satisfaction are dependent on volume retention over time. The study objectives were to determine how immediate breast volume changes correlate to implanted graft volumes, to understand long-term adipose graft volume changes, and to study the "dose" effect of adding autologous stromal vascular fraction (SVF) cells to fat grafts on long-term volume retention. Read More

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http://dx.doi.org/10.1097/GOX.0000000000000511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634184PMC
October 2015
19 Reads

The Process of Breast Augmentation with Special Focus on Patient Education, Patient Selection and Implant Selection.

Clin Plast Surg 2015 Oct;42(4):413-26

Plastic Surgery, Weill Cornell Medical College, New York, NY, USA; Plastic Surgery, New York Presbyterian Hospital, 156 William Street, 12th Floor, New York, NY 10038, USA.

Breast augmentation remains one of the most commonly performed plastic surgical procedures worldwide; however, Food and Drug Administration clinical trials have suggested that this procedure has a reoperation rate of 14% to 24% after 3 years. Recent literature has proposed that breast augmentation should not only be a surgical procedure but ultimately a surgical process to reduce postoperative complications and enhance patient satisfaction. The process of breast augmentation has been documented to optimize postsurgical outcomes and includes the following 4 steps: patient education, tissue-based planning, refined surgical techniques, and defined postoperative management. Read More

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http://dx.doi.org/10.1016/j.cps.2015.06.001DOI Listing
October 2015
1 Read

Mammographic findings after reshaping with autoprosthesis in women undergoing contralateral breast reconstruction and mastectomy.

Tumori 2016 Jan-Feb;102(1):77-83. Epub 2015 Sep 10.

Department of Diagnostic Radiology 1, Breast Imaging, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy.

Aims And Background: Breast reduction and mastopexy combined with inferior dermo-lipo-glandular flap (autoprosthesis) gives good breast shape, long-term projection, and upper pole fullness. We assess the impact on breast oncologic surveillance compared to other techniques.

Methods: A total of 105 patients who underwent mastectomy and reconstruction were divided into 3 groups of 35 patients each: groups 1 and 2 include patients with contralateral breast symmetrization performed with and without autoprosthesis technique, respectively. Read More

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http://dx.doi.org/10.5301/tj.5000395DOI Listing
July 2016
9 Reads

Liposuction for Advanced Lymphedema: A Multidisciplinary Approach for Complete Reduction of Arm and Leg Swelling.

Ann Surg Oncol 2015 Dec 30;22 Suppl 3:S1263-70. Epub 2015 Jun 30.

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, 2 Technology Place, Macquarie University, Sydney, NSW, Australia.

Purpose: This research describes and evaluates a liposuction surgery and multidisciplinary rehabilitation approach for advanced lymphedema of the upper and lower extremities.

Methods: A prospective clinical study was conducted at an Advanced Lymphedema Assessment Clinic (ALAC) comprised of specialists in plastic surgery, rehabilitation, imaging, oncology, and allied health, at Macquarie University, Australia. Between May 2012 and 31 May 2014, a total of 104 patients attended the ALAC. Read More

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http://link.springer.com/content/pdf/10.1245%2Fs10434-015-47
Web Search
http://link.springer.com/10.1245/s10434-015-4700-3
Publisher Site
http://dx.doi.org/10.1245/s10434-015-4700-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686553PMC
December 2015
22 Reads

Rates of presurgical underestimation of breast cancer after standardized assessment of breast calcifications.

Rofo 2015 Jun 15;187(6):445-9. Epub 2015 Apr 15.

Department of Clinical Radiology and Reference Center for Mammography, University Hospital Muenster, Germany.

Purpose: To determine the frequency of histopathological underestimation of breast cancer after vacuum-assisted biopsy (VAB) in standardized assessment of breast calcifications compared to postsurgical diagnosis.

Materials And Methods: The retrospective study included acquired data of 506 consecutively examined women, who underwent VAB for the assessment of pure calcifications after standardized digital mammographic and sonographic imaging. 119/506 (24. Read More

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http://dx.doi.org/10.1055/s-0034-1399273DOI Listing
June 2015
2 Reads

Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.

Cancer Cell 2014 Dec;26(6):880-895

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69121 Heidelberg, Germany; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

Antiangiogenic tumor therapy has failed in the adjuvant setting. Here we show that inhibition of the Tie2 ligand angiopoietin-2 (Ang2) effectively blocks metastatic growth in preclinical mouse models of postsurgical adjuvant therapy. Ang2 antibody treatment combines well with low-dose metronomic chemotherapy (LDMC) in settings in which maximum-dose chemotherapy does not prove effective. Read More

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http://www.cell.com/cancer-cell/pdf/S1535-6108(14)00456-5.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081400456
Publisher Site
http://dx.doi.org/10.1016/j.ccell.2014.11.005DOI Listing
December 2014
23 Reads

Human epidermal growth factor receptor 2-positive breast cancer: heat shock protein 90 overexpression, Ki67 proliferative index, and topoisomerase II-α co-amplification as predictors of pathologic complete response to neoadjuvant chemotherapy with trastuzumab and docetaxel.

Clin Breast Cancer 2015 Feb 23;15(1):16-23. Epub 2014 Jun 23.

Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.

Background: The combination of trastuzumab and chemotherapy is currently considered the standard of care for patients with locally advanced/operable human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The potential correlation between the pathologic complete response (pCR) and the overexpression of heat shock protein 90 (Hsp90), Ki67, and the amplification of topoisomerase II-α (TOPO2A) was investigated in a series of patients who received neoadjuvant treatment.

Methods: HER2-amplified patients who received neoadjuvant trastuzumab-docetaxel were gathered. Read More

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http://dx.doi.org/10.1016/j.clbc.2014.05.004DOI Listing
February 2015
19 Reads

Contrast-enhanced spectral mammography: Does mammography provide additional clinical benefits or can some radiation exposure be avoided?

Breast Cancer Res Treat 2014 Jul 2;146(2):371-81. Epub 2014 Jul 2.

Clinic of Radiology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany,

The purpose of this study was to compare contrast-enhanced spectral mammography (CESM) with mammography (MG) and combined CESM + MG in terms of detection and size estimation of histologically proven breast cancers in order to assess the potential to reduce radiation exposure. A total of 118 patients underwent MG and CESM and had final histological results. CESM was performed as a bilateral examination starting 2 min after injection of iodinated contrast medium. Read More

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http://dx.doi.org/10.1007/s10549-014-3023-6DOI Listing
July 2014
32 Reads

Update on imaging of the postsurgical breast.

Radiographics 2014 May-Jun;34(3):642-60

From the Department of Radiology, Breast Imaging Section, New York University School of Medicine, Langone Medical Center, 550 First Ave, New York, NY 10016.

Oncologic, reconstructive, and cosmetic breast surgery has evolved in the last 20 years. Familiarity with cutting-edge surgical techniques and their imaging characteristics is essential for radiologic interpretation and may help avert false-positive imaging findings. Novel surgical techniques include skin- and nipple-sparing mastectomies, autologous free flaps, autologous fat grafting, and nipple-areola-complex breast reconstruction. Read More

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http://dx.doi.org/10.1148/rg.343135059DOI Listing
February 2015
5 Reads

Imaging of breast cancer-related changes after surgical therapy.

AJR Am J Roentgenol 2014 Feb;202(2):262-72

1 Department of Radiology, University of Michigan Health System, Ann Arbor, MI.

Objective: The purpose of this article is to discuss the surgical treatment of breast cancer and its resultant thoracic CT and multimodality imaging manifestations.

Conclusion: Many breast cancer patients undergo cross-sectional imaging at some point during or after treatment. Thoracic CT is an important modality performed for staging and surveillance. Read More

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http://dx.doi.org/10.2214/AJR.13.11517DOI Listing
February 2014
2 Reads

Current technological advances in magnetic resonance with critical impact for clinical diagnosis and therapy.

Authors:
Val M Runge

Invest Radiol 2013 Dec;48(12):869-77

From the University Hospital Zurich, Switzerland.

The last 5 years of technological advances with major impact on clinical magnetic resonance (MR) are discussed, with greater emphasis on those that are most recent. These developments have already had a critical positive effect on clinical diagnosis and therapy and presage continued rapid improvements for the next 5 years. This review begins with a discussion of 2 topics that encompass the breadth of MR, in terms of anatomic applications, contrast media, and MR angiography. Read More

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http://dx.doi.org/10.1097/01.rli.0000434380.71793.d3DOI Listing
December 2013
5 Reads

Imaging response and residual metastatic axillary lymph node disease after neoadjuvant chemotherapy for primary breast cancer.

Ann Surg Oncol 2013 Oct 12;20(10):3199-204. Epub 2013 Jul 12.

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Although surgical management of the breast after neoadjuvant chemotherapy (NAC) may be governed by treatment response, axillary management continues to be determined by stage at presentation. Axillary ultrasound (AUS) with fine-needle aspiration (FNA) is used to detect lymph node (LN) metastases for pre-NAC staging, but imaging assessment of treatment response in the axilla remains undefined. We evaluated post-NAC axillary imaging and surgical pathology to understand how imaging might direct axillary surgery. Read More

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http://dx.doi.org/10.1245/s10434-013-3118-zDOI Listing
October 2013
8 Reads

Evaluation of residual disease using breast MRI after excisional biopsy for breast cancer.

AJR Am J Roentgenol 2013 May;200(5):1167-73

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Seoul, Korea.

Objective: The purpose of our study was to assess the diagnostic performance of breast MRI in evaluating residual disease in patients after excisional biopsy for breast cancer on the basis of both morphologic and kinetic features.

Materials And Methods: Of 5304 breast MRI examinations performed between January 2007 and December 2011, 308 evaluated postoperative sites after excisional biopsy of breast cancer. Among these, 203 patients who were not treated with chemotherapy or radiotherapy before MRI and underwent definitive surgery within 30 days after MRI were enrolled. Read More

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http://dx.doi.org/10.2214/AJR.12.9275DOI Listing
May 2013
6 Reads

Variation among local health units in follow-up care of breast cancer patients in Emilia-Romagna, Italy.

Tumori 2013 Jan-Feb;99(1):30-4

Ospedale Civile Ravenna, Ravenna, Italy.

Aims And Background: This study examines the patterns of follow-up care for breast cancer survivors in one region in Italy.

Methods And Study Design: This retrospective analysis included 10,024 surgically treated women, with incident cases of breast cancer in the years 2002-2005 who were alive 18 months after their incidence date. Rates of use of follow-up mammograms, abdominal echogram, bone scans and chest x-rays were estimated from administrative data and compared by Local Health Unit (LHU) of residence. Read More

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http://dx.doi.org/10.1700/1248.13784DOI Listing
May 2013
2 Reads

Physiological and tumoral uptake of (68)Ga-DOTATATE: standardized uptake values and challenges in interpretation.

Ann Nucl Med 2013 Jul 31;27(6):538-45. Epub 2013 Mar 31.

Nükleer Tıp Anabilim Dali, Istanbul Üniversitesi, Istanbul Tip Fakultesi, Fatih, Istanbul, 34390, Turkey.

Purpose: The objective of this study is to determine the range of SUVmax of 68Ga-DOTATATE in normal organs and tumoral lesions and establish uptake unrelated to NET.

Materials And Methods: One hundred and twenty patients (57 men, 63 women), who underwent (68)Ga-DOTATATE PET/CT imaging in our institution were analyzed. Patients were indicated for (68)Ga-DOTATATE PET/CT imaging to detect primary tumor or metastasis of suspected or previously known NET, to determine SSTR positivity and to detect occult source of ectopic Cushing syndrome. Read More

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http://link.springer.com/10.1007/s12149-013-0718-4
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http://dx.doi.org/10.1007/s12149-013-0718-4DOI Listing
July 2013
19 Reads

Imaging-pathologic correlation of diseases in the axilla.

AJR Am J Roentgenol 2013 Feb;200(2):W130-42

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, 633-165 Gaegeum-dong, Busanjin-gu, Busan 614-735, South Korea.

Objective: This article reviews the imaging and histopathologic findings of various axillary diseases and suggests management guidelines for radiologists based on imaging findings with clinical correlation.

Conclusion: Although axillary diseases may reveal nonspecific imaging findings, a knowledge of the characteristic radiologic manifestations of specific diseases according to anatomic origin (nodal, accessory breast, adipocytic, fibrous, nerve, vascular, stromal, and dermal) and postsurgical lesions aids in establishing an appropriate differential diagnosis and determining whether intervention is necessary. Read More

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http://www.ajronline.org/doi/10.2214/AJR.12.9259
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http://dx.doi.org/10.2214/AJR.12.9259DOI Listing
February 2013
6 Reads

Surgically induced SMART syndrome: case report and review of the literature.

World Neurosurg 2014 Jul-Aug;82(1-2):240.e7-12. Epub 2013 Jan 10.

Department of Neurosurgery, Mayo Clinic, College of Medicine, Rochester, Minnesota, USA. Electronic address:

Background: Strokelike migraine attack after radiation therapy is a recently described clinical entity characterized by transient hemispheric dysfunction manifesting as, but not limited to, visuospatial deficits, confusion, hemisensory deficits, hemiparesis, aphasia, seizures, and, most prominently, headache in patients with a history of remote external beam radiation therapy to the brain. The radiographic hallmark on magnetic resonance imaging is the presence of transient, diffuse, unilateral gadolinium enhancement of the cortex with white matter sparing, usually corresponding to the previous radiation field.

Case Description: We present a case of strokelike migraine attacks after radiation therapy syndrome diagnosed immediately following a craniotomy and temporal lobectomy for recurrent metastatic tumor resection after prior gamma knife radiosurgery and whole-brain radiation therapy. Read More

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http://dx.doi.org/10.1016/j.wneu.2013.01.028DOI Listing
October 2014
1 Read
2.417 Impact Factor

Breast reconstruction with a deep inferior epigastric perforator flap: imaging appearances of the normal flap and common complications.

AJR Am J Roentgenol 2013 Jan;200(1):W75-84

Avon Comprehensive Breast Evaluation Center, Massachusetts General Hospital, Wang Bldg Ste 240, Boston, MA 02114, USA.

Objective: The purpose of this essay is to illustrate the normal imaging appearance of deep inferior epigastric perforator (DIEP) flap breast reconstruction and common postoperative complications.

Conclusion: Familiarity with the anatomy and normal imaging appearance of a DIEP flap reconstruction will help the breast imager recognize normal postsurgical findings and common postoperative complications. Read More

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http://dx.doi.org/10.2214/AJR.12.9270DOI Listing
January 2013
45 Reads

Postsurgical treatment of early-stage breast cancer with electronic brachytherapy: outcomes and health-related quality of life at 1 year.

Am J Clin Oncol 2013 Oct;36(5):430-5

¶¶Beverly Oncology & Imaging Medical Center ##Odou and Nugent MDs, Montebello *Western Radiation Oncology Inc., Pleasanton, CA †Dallas Surgical Group ‡Northpoint Cancer Center, Dallas, TX §Breast Specialists ∥AtlantiCare Regional Medical Center, Egg Harbor Township, NJ ¶DCH Regional Medical Center, Tuscaloosa, AL #Memorial and St Elizabeth's Cancer Treatment Center, Swansea **Southern Illinois Surgical Consultants, Maryville, IL ††Florida Radiation Oncology ‡‡North Florida Surgeons, Orange Park, FL §§Cancer Institute of Cape Girardeau ∥∥Cape Girardeau Surgical Clinic, Cape Girardeau, MO ***Shields Health Care Group, Quincy †††Surgical Associates, Taunton §§§Brockton Hospital, Brockton, MA ‡‡‡Beth Israel Medical Center, New York, NY.

Objectives: This multicenter registry followed up patients with early-stage breast cancer treated with breast-conserving surgery and electronic brachytherapy (EBT). This report provides 1- and 2-year updates to the initial publication.

Methods: Patients were of age 50 years or more with invasive carcinoma or ductal carcinoma in situ, tumor size ≤3 cm, and negative surgical margins. Read More

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http://dx.doi.org/10.1097/COC.0b013e31825493bbDOI Listing
October 2013
22 Reads

Undiagnosed breast cancer at MR imaging: analysis of causes.

Radiology 2012 Jul 20;264(1):40-50. Epub 2012 Apr 20.

Department of Medical Imaging, CHU Lapeyronie, 371 avenue du Doyen Gaston Giraud, 34295 Montpellier, France.

Purpose: To retrospectively review the causes of false-negative results on prior magnetic resonance (MR) imaging studies in patients who developed breast cancer as revealed on a follow-up MR imaging study and to determine the presumptive causes of these false-negative findings.

Materials And Methods: Fifty-eight pairs of MR imaging studies from one institution were assessed, consisting of a prior study without a diagnosis of cancer and a diagnostic study with subsequent findings of 60 cancers in 58 women at MR imaging (mean interval between prior and diagnostic MR examinations, 13.8 months). Read More

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http://pubs.rsna.org/doi/10.1148/radiol.12111917
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http://dx.doi.org/10.1148/radiol.12111917DOI Listing
July 2012
3 Reads

False-positive lesions mimicking breast cancer on FDG PET and PET/CT.

AJR Am J Roentgenol 2012 Mar;198(3):W304-14

Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030, USA.

Objective: Incidental (18)F-FDG-avid breast lesions are commonly encountered in patients with cancer who undergo staging PET/CT. This pictorial essay discusses breast lesions that show increased FDG activity, mimicking breast cancer, with biopsy-confirmed benign diagnosis.

Conclusion: Acute and chronic inflammation, physiologic lactation, and benign breast masses, including silicone granuloma, fat necrosis, fibroadenoma, and postsurgical changes, may show increased FDG uptake on PET/CT. Read More

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http://dx.doi.org/10.2214/AJR.11.7130DOI Listing
March 2012
1 Read

Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia?

AJR Am J Roentgenol 2012 Feb;198(2):288-91

Department of Radiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada.

Objective: The aims of our study were to determine the frequency of malignancy after surgical excision of biopsy-proven lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (ALH) lesions, to assess any difference between pure LCIS and pure ALH lesions regarding their radiologic presentation and the malignancy upgrade rate after surgical excision, and to evaluate the outcome of lesions that were not excised surgically but were followed up.

Materials And Methods: Radiologic and pathologic records of 14,435 imaging-guided needle biopsies of the breast performed between 2004 and 2008 in three different institutions were retrospectively reviewed. A total of 126 patients (0. Read More

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http://dx.doi.org/10.2214/AJR.11.7212DOI Listing
February 2012
5 Reads

Mammographic changes after fat transfer to the breast compared with changes after breast reduction: a blinded study.

Plast Reconstr Surg 2012 May;129(5):1029-38

Division of Plastic Surgery, University of Pittsburgh Medical Center, 4553 Terrace Street, 6B Scaife Hall, Pittsburgh, PA 15261, USA.

Background: : One issue in the adoption of autologous fat transfer to the breast is concern over mammographic changes that may obscure cancer detection. The authors compared mammographic changes following fat grafting to the breast with changes seen after breast reduction.

Methods: : Twenty-seven women who had normal preoperative mammograms were treated with fat grafting to the breast, including admixing of autologous adipose stem cells with the fat graft, for cosmetic augmentation. Read More

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http://pdfs.journals.lww.com/plasreconsurg/2012/05000/Discus
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PRS.0b013e31824a2a8eDOI Listing
May 2012
3 Reads

Clinical and imaging surveillance following breast cancer diagnosis.

Am Soc Clin Oncol Educ Book 2012 :59-64

From the H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, and University of South Florida, Tampa, FL.

Breast cancer is the most common malignancy affecting women worldwide. Women have a 1 in 8 lifetime risk of breast cancer. Breast conservation therapy (BCT) is the most common method of definitive treatment. Read More

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http://dx.doi.org/10.14694/EdBook_AM.2012.32.59DOI Listing
April 2016
1 Read

Factors associated with the development of new onset diffuse thyroid F18-fluorodeoxyglucose uptake after treatment of breast cancer in patients without a history of thyroid disease or thyroid dysfunction.

Thyroid 2012 Jan 5;22(1):53-8. Epub 2011 Dec 5.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.

Background: Many studies have shown an association between thyroid disorders and breast cancer. Among them, diffusely increased thyroid uptake of F18-fluorodeoxyglucose (F-18 FDG) has been associated with chronic lymphocytic thyroiditis. There is little or no information regarding the relationship between treatment of breast cancer and the development of new diffuse thyroid F-18 FDG uptake. Read More

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http://dx.doi.org/10.1089/thy.2011.0013DOI Listing
January 2012
4 Reads

Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment.

Proc Natl Acad Sci U S A 2011 Aug 18;108(35):14626-31. Epub 2011 Aug 18.

Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92617, USA.

Approximately 8-20% of breast cancer patients receiving neoadjuvant chemotherapy fail to achieve a measurable response and endure toxic side effects without benefit. Most clinical and imaging measures of response are obtained several weeks after the start of therapy. Here, we report that functional hemodynamic and metabolic information acquired using a noninvasive optical imaging method on the first day after neoadjuvant chemotherapy treatment can discriminate nonresponding from responding patients. Read More

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http://www.pnas.org/content/108/35/14626.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1013103108
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http://dx.doi.org/10.1073/pnas.1013103108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167535PMC
August 2011
5 Reads

Bone quantitative ultrasound at hand phalanges of women following breast cancer surgery.

Gynecol Endocrinol 2011 Dec 15;27(12):1048-51. Epub 2011 Apr 15.

Department of Endocrinology, Diabetology and Isotope Therapy, Medical University, Wrocław, Poland.

Breast cancer surgery and its adjunctive therapy follow in lymphedema, decreased limb mobility and bone deterioration. The aim was to establish relation of postsurgical limb lymphedema with bone properties assessed by quantitative ultrasound (QUS) measurement of hand phalanges in postmenopausal women after breast cancer surgery. In all, 63 women aged 62. Read More

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http://www.tandfonline.com/doi/full/10.3109/09513590.2011.56
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http://dx.doi.org/10.3109/09513590.2011.569789DOI Listing
December 2011
2 Reads