170 results match your criteria Postradiation Sarcoma


Rectotumoral fistula formation occurring more than 5 years after carbon ion radiotherapy for sacral chordoma: A case report.

Mol Clin Oncol 2019 May 5;10(5):487-491. Epub 2019 Mar 5.

Musculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka, Osaka 541-8567, Japan.

Chordoma is a rare tumor that originates from the notochord. Half of chordomas involve the sacral region. Surgery is considered to be the standard treatment for sacral chordoma. Read More

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http://dx.doi.org/10.3892/mco.2019.1821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449880PMC
May 2019
2 Reads

Undifferentiated sarcoma of the pericardium after radiation therapy for Hodgkin's lymphoma.

Ter Arkh 2018 Aug;90(8):69-73

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia.

Primary sarcomas of the pericardium are extremely rare malignant tumors of the heart. The incidence of sarcoma increases after radiation therapy in the field of breast. The specific features of this case report are the difficulties in diagnostics of undifferentiated spindle-cell sarcoma of the pericardium and the connection between the disease and the radiation therapy for Hodgkin's lymphoma. Read More

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http://dx.doi.org/10.26442/terarkh201890869-73DOI Listing
August 2018
1 Read

Kaposi Sarcoma and Cutaneous Angiosarcoma: Guidelines for Diagnosis and Treatment.

Actas Dermosifiliogr 2018 Dec 24;109(10):878-887. Epub 2018 Sep 24.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. Electronic address:

Kaposi sarcoma is a vascular sarcoma with 4 clinical variants: classic Kaposi sarcoma, which mainly affect the extremities of elderly patients and follows a chronic, generally indolent course; African Kaposi sarcoma; immunosuppression-associated Kaposi sarcoma; and AIDS-associated Kaposi sarcoma. Type8 human herpesvirus is the etiologic agent in all 4variants. Cutaneous angiosarcoma is a cutaneous neoplasm with a very poor prognosis. Read More

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http://dx.doi.org/10.1016/j.ad.2018.06.013DOI Listing
December 2018
25 Reads

Secondary spindle cell sarcoma following external beam radiotherapy for prostate cancer: a rare but devastating complication.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Urology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

We report a case of rapidly growing sarcoma that resulted in mortality only 6 years after radiotherapy for low-grade prostate cancer.At the age of 69 years and a prostate-specific antigen (PSA) that had risen to 9.0 µg/L, transrectal ultrasound-guided biopsy of the prostate found a single core of Gleason 3+3 disease involving 4 mm of a 10 mm core. Read More

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http://dx.doi.org/10.1136/bcr-2018-225295DOI Listing
July 2018
10 Reads

Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome.

Case Rep Pathol 2018 24;2018:5947870. Epub 2018 Apr 24.

Department of Pathology, UAB, Birmingham, AL, USA.

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms. Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation. We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy. Read More

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http://dx.doi.org/10.1155/2018/5947870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941799PMC
April 2018
4 Reads

Follicular dendritic cell sarcoma presenting as a painless lump in the parotid.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.

Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of the antigen presenting cells of the immune system. The majority occur in lymph nodes but around 30% can occur extranodally including in the spleen, lungs, head and neck and liver. We present an unusual case of an FDCS of the parotid gland in a 51-year-old woman with a history of Hodgkin's lymphoma treated with combination chemotherapy and modified mantle radiotherapy. Read More

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http://dx.doi.org/10.1136/bcr-2018-224301DOI Listing
May 2018
8 Reads

Parosteal osteosarcoma of mandible: A rare case report.

J Cancer Res Ther 2018 Jan-Mar;14(2):471-474

Department of Oral Medicine and Radiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

With the exception of multiple myelomas, osteosarcoma is the most frequently occurring primary malignant bone tumor with an overall incidence of 1:100,000/year. It has greatest predilection for the metaphyses, most frequently femur and tibia. However, osteosarcomas affecting the craniofacial bones are infrequent. Read More

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http://dx.doi.org/10.4103/0973-1482.176420DOI Listing
August 2018
10 Reads

Quadruple Neoplasms following Radiation Therapy for Congenital Bilateral Retinoblastoma.

Ocul Oncol Pathol 2017 Dec 6;4(1):33-37. Epub 2017 Jul 6.

Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Purpose: The aim of this study was to describe a 34-year-old male with hereditary bilateral retinoblastoma treated with radiotherapy as a child who developed 4 distinct tumors within the radiation field.

Methods: A 34-year-old male with bilateral retinoblastoma status postradiation therapy and recurrence requiring enucleation presented with left-eye visual acuity changes. Magnetic resonance imaging demonstrated a left orbital mass and a right parasellar complex lobulated mass (right sphenoid and right cavernous sinus). Read More

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http://dx.doi.org/10.1159/000477410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757554PMC
December 2017
14 Reads

Postradiation Synovial Sarcoma of the Common Bile Duct: A Previously Unreported Anatomic Site.

Int J Surg Pathol 2018 Aug 16;26(5):469-474. Epub 2018 Jan 16.

1 Instituto Nacional de Cancerología, México City, México.

Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11. Read More

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http://dx.doi.org/10.1177/1066896917752863DOI Listing
August 2018
3 Reads

Mesenchymal tumors of the prostate.

Authors:
Jesse K McKenney

Mod Pathol 2018 Jan;31(S1):S133-142

Robert J Tomsich Pathology and Laboratory Medicine Institute, Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.

Mesenchymal tumors of the prostate are rare but often cause considerable diagnostic difficulty when encountered. These may be either benign or malignant and can arise within the prostate gland or in adjacent tissues. This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth muscle neoplasms (leiomyoma and leiomyosarcoma), gastrointestinal stromal tumor, schwannoma, rhabdomyosarcoma, sarcomatoid carcinoma, postradiation sarcoma, and mixed epithelial stromal tumor of the seminal vesicle. Read More

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http://dx.doi.org/10.1038/modpathol.2017.155DOI Listing
January 2018
24 Reads

Unusual Presentation of Postradiation Sarcoma With Subsequent Intestinal Metastasis Revealed by 18F-FDG PET/CT.

Clin Nucl Med 2017 Oct;42(10):e438-e440

From the *Department of Nuclear Medicine, and †Division of Radiology Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.

Radiation-related sarcoma is a rare but serious complication for patients after receiving radiation therapy initially for their primary malignancy. However, it usually takes several years and needs enough in-field radiation dose to develop this sarcoma. We describe a 60-year-old man with right axillary sarcoma revealed by whole-body F-FDG PET/CT 1 year after chemoradiotherapy, which presented ultrashort latency period and did not match the consensus definition of radiation-related sarcoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001779DOI Listing
October 2017
6 Reads

Pathological characteristics of spine metastases treated with high-dose single-fraction stereotactic radiosurgery.

Neurosurg Focus 2017 Jan;42(1):E7

Departments of1Radiation Oncology.

OBJECTIVE Spine radiosurgery is increasingly being used to treat spinal metastases. As patients are living longer because of the increasing efficacy of systemic agents, appropriate follow-up and posttreatment management for these patients is critical. Tumor progression after spine radiosurgery is rare; however, vertebral compression fractures are recognized as a more common posttreatment effect. Read More

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http://dx.doi.org/10.3171/2016.10.FOCUS16368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548126PMC
January 2017
19 Reads

Isolated Unilateral Tongue Atrophy: A Possible Late Complication of Juxta Cephalic Radiation Therapy.

Am J Case Rep 2016 Jul 26;17:535-7. Epub 2016 Jul 26.

Department of Neurology, The School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.

BACKGROUND Isolated unilateral hypoglossal nerve injury is extremely rare. It may be caused by radiation therapy targeting neoplasms of the cephalic region. CASE REPORT A 51-year-old man with synovial sarcoma of the left upper arm status post extensive radiation therapy in 1980 presented in late 2014 with gradual onset of speech difficulty and difficulty moving his tongue for a couple of weeks. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968431PMC
July 2016
3 Reads

SAFETY AND TOXICITY OF AN ACCELERATED COARSELY FRACTIONATED RADIATION PROTOCOL FOR TREATMENT OF APPENDICULAR OSTEOSARCOMA IN 14 DOGS: 10 GY × 2 FRACTIONS.

Vet Radiol Ultrasound 2016 Sep 4;57(5):551-6. Epub 2016 Jul 4.

Department of Veterinary Clinical Sciences, Louisiana State University, Skip Bertman Dr., Baton Rouge, LA, 70803.

Coarsely fractionated radiation is commonly used as a method for pain control in dogs with appendicular osteosarcoma, however there is little published information on optimal protocols. The aim of this retrospective, descriptive study was to report safety and toxicity findings in a sample of dogs with appendicular osteosarcoma that had been treated with a radiation scheme of 10 Gy delivered over two consecutive days for a total of 20 Gy. Dogs were included in the study if they had osteosarcoma that was treated with the aforementioned protocol. Read More

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http://dx.doi.org/10.1111/vru.12389DOI Listing
September 2016
4 Reads

Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features.

Arch Pathol Lab Med 2016 May;140(5):477-81

From the Departments of Anatomic Pathology (Drs Shah and Rosa) and Women's Oncology (Dr Rosa), Moffitt Cancer Center, Tampa, Florida.

Breast angiosarcoma is an unusual malignancy accounting for approximately 1% of soft tissue sarcomas. It can occur as a primary form without a known precursor or as a secondary form associated with radiotherapy. Adjuvant radiotherapy has a significant role in preventing local recurrence in women treated with conservation therapy for early stage breast carcinoma or multicentric tumors. Read More

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http://dx.doi.org/10.5858/arpa.2014-0581-RSDOI Listing
May 2016
9 Reads

Photoletter to the editor: Postradiation sarcoma.

J Dermatol Case Rep 2016 Mar 31;10(1):17-8. Epub 2016 Mar 31.

Dermatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain;

Postradiation sarcomas are rare and highly malignant tumors which may appear as a consequence of radiotherapy. They may originate on bone or soft tissues.We report the case of a patient who developed a malignant fibrous histiocytoma 35 years after radiotherapy for a melanoma on her right leg. Read More

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http://dx.doi.org/10.3315/jdcr.2016.1228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844531PMC
March 2016
11 Reads

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma.

Tex Heart Inst J 2016 Feb 1;43(1):81-3. Epub 2016 Feb 1.

Therapeutic radiotherapy rarely causes sarcoma, and this occurs years after completion of the intended treatment. In treating breast carcinoma, careful planning in the application of modern radiotherapeutic techniques usually can shield the heart and pericardium. We report a rare case of angiosarcoma of the pericardium, which presented in a 41-year-old woman as constrictive pericarditis 8 years after irradiation for cancer of the left breast. Read More

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http://dx.doi.org/10.14503/THIJ-14-4549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810594PMC
February 2016
4 Reads

Postradiation angiosarcoma of bladder with extensive osseous metaplasia.

Indian J Pathol Microbiol 2016 Jan-Mar;59(1):78-80

Department of Histopathology, Apollo Hospital, Hyderabad, Telangana, India.

Angiosarcomas are rare soft tissue neoplasms accounting for <2% of all sarcomas. Rare cases have been reported in other sites like breast, spleen, liver, bone and bladder. This is a case report of an angiosarcoma of the bladder in a 65 year old lady who came with complaints of haematuria. Read More

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http://dx.doi.org/10.4103/0377-4929.178234DOI Listing
January 2017
10 Reads

Postradiation carcinosarcoma of the corpus uteri--a case report.

Eur J Gynaecol Oncol 2015 ;36(6):746-9

Introduction: Radiation therapy is a very effective treatment modality, commonly used for numerous gynecological malignancies, e.g. cervical cancer. Read More

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February 2016
3 Reads

Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.

Mod Pathol 2016 Jan 20;29(1):4-13. Epub 2015 Nov 20.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). Read More

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http://dx.doi.org/10.1038/modpathol.2015.134DOI Listing
January 2016
25 Reads

HYPOFRACTIONATED RADIOTHERAPY FOR MACROSCOPIC CANINE SOFT TISSUE SARCOMA: A RETROSPECTIVE STUDY OF 50 CASES TREATED WITH A 5 × 6 GY PROTOCOL WITH OR WITHOUT METRONOMIC CHEMOTHERAPY.

Vet Radiol Ultrasound 2016 Jan 9;57(1):75-83. Epub 2015 Nov 9.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, CH-8057, Zurich, Switzerland.

Wide surgical resection or a marginal/incomplete resection followed by full-course radiation therapy is the current standard of care for canine soft tissue sarcoma. The purpose of this retrospective, descriptive, bi-institutional study was to determine the effectiveness and toxicity of a hypofractionated 5 × 6 Gy protocol on macroscopic canine soft tissue sarcoma in terms of progression-free interval (PFI) and overall survival (OS), and to identify prognostic factors for patient outcome. Dogs with macroscopic soft tissue sarcoma irradiated with 5 × 6 Gy were eligible for the study. Read More

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http://doi.wiley.com/10.1111/vru.12308
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http://dx.doi.org/10.1111/vru.12308DOI Listing
January 2016
46 Reads

Radiation-induced Sarcomas Occurring in Desmoid-type Fibromatosis Are Not Always Derived From the Primary Tumor.

Am J Surg Pathol 2015 Dec;39(12):1701-7

Departments of *Medical Oncology †Pathology ∥Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands ‡Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Centre, Nashville, TN §Department of Pathology, Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX ¶Robert J. Tomsich Pathology and Laboratory Medicine Institute, and Molecular Genetics, Cleveland Clinic, Taussig Cancer Centre and Lerner Research Institute, Cleveland, OH.

Desmoid-type fibromatosis is a rare, highly infiltrative, locally destructive neoplasm that does not metastasize, but recurs often after primary surgery. Activation of the Wnt/β-catenin pathway is the pathogenic mechanism, caused by an activating mutation in exon 3 of CTNNB1 (85% of the sporadic patients). Radiotherapy is a frequent treatment modality with a local control rate of approximately 80%. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000510DOI Listing
December 2015
13 Reads

Postradiation Extraskeletal Osteosarcoma Masquerading as an Axillary Artery Pseudoaneurysm.

Ann Vasc Surg 2016 Jan 17;30:157.e7-9. Epub 2015 Aug 17.

Department of Vascular Surgery, Sydell and Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH.

Background: A 68-year-old woman with a thoracoabdominal aortic aneurysm recently status after first-stage elephant trunk procedure with right brachiocephalic artery endarterectomy and reimplantation of the innominate and left carotid using a 14 × 10-mm branch graft presented to clinic with increasing pain in her right arm and shoulder for 2 weeks. She also had a remote history of radiation to the right axilla for breast cancer. On physical examination, she had a tender mass under her clavicle, numbness in shoulder and right hand weakness. Read More

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http://dx.doi.org/10.1016/j.avsg.2015.06.069DOI Listing
January 2016
4 Reads

Postradiation dermatofibrosarcoma protuberans : case report and literature review.

Acta Chir Belg 2015 Jan-Feb;115:87-90

Division of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Radiotherapy has long been known to induce soft tissue sarcomas. However, there are only six cases of postradiation dermatofibrosarcoma protuberans (DFSP) reported in the literature, and no case in Asians has been reported so far. Herein, we report a case of DFSP, confirmed by immunohistochemistry, which developed on the old scar at the irradiated right chest wall of an Asian woman. Read More

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November 2015
13 Reads

Secondary osteosarcoma: is there a predilection for the chondroblastic subtype?

Orthopedics 2015 May;38(5):e359-66

Osteosarcoma is the most common form of primary bone cancer in the adolescent and young adult patient population. Outcomes in patients with secondary osteosarcoma are inferior compared with outcomes in patients with primary osteosarcoma. The goal of this study was to investigate whether there is a predilection for the chondroblastic histologic subtype in secondary osteosarcoma. Read More

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http://dx.doi.org/10.3928/01477447-20150504-51DOI Listing
May 2015
4 Reads

Radiation-induced Chondrosarcoma of the Bladder. Case Report and Review of Literature.

Anticancer Res 2015 May;35(5):2857-60

Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.

Background: Chondrosarcoma of the bladder is an extremely rare disease. Only five previously described cases are known in the medical literature.

Patients And Methods: We present a chondrosarcoma developed 19 years after radiation treatment in a 73-year-old patient. Read More

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May 2015
4 Reads

The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast.

Hum Pathol 2015 Jun 10;46(6):868-75. Epub 2015 Mar 10.

Department of Pathology, University of Massachusetts Medical School, UMass Memorial Medical Center, Worcester, MA, 01605, USA.

Atypical vascular lesions (AVLs) and angiosarcomas (ASs) are well-recognized complications of radiotherapy for breast cancer. Early diagnosis may be challenging, particularly on small biopsies, and the treatment options are limited. Recently, MYC and sometimes FLT4 gene amplification has been reported in AS, but not in AVL, and FLT4 may be a target for therapy. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.02.014DOI Listing
June 2015
12 Reads

Can c-myc amplification reliably discriminate postradiation from primary angiosarcoma of the breast?

Cancer Radiother 2015 May 8;19(3):168-74. Epub 2015 Apr 8.

Département d'oncologie radiothérapie, 26, rue d'Ulm, 75005 Paris, France. Electronic address:

Purpose: Breast angiosarcomas are rare vascular malignancies that arise secondary to irradiation or de novo as primary tumours. The aim of this study is to know whether c-myc amplification can reliably discriminate these two entities.

Materiel And Methods: Forty-seven patients treated for breast angiosarcomas were studied. Read More

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http://dx.doi.org/10.1016/j.canrad.2015.01.001DOI Listing
May 2015
5 Reads

Postradiation Dermatofibrosarcoma Protuberans: Case Report and Literature Review.

Acta Chir Belg 2015 Jan;115(1):87-90

a Division of Plastic and Reconstructive Surgery, Department of Surgery , Taipei , Taiwan.

Radiotherapy has long been known to induce soft tissue sarcomas. However, there are only six cases of post-radiation dermatofibrosarcoma protuberans (DFSP) reported in the literature, and no case in Asians has been reported so far. Herein, we report a case of DFSP, confirmed by immunohistochemistry, which developed on the old scar at the irradiated right chest wall of an Asian woman. Read More

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http://dx.doi.org/10.1080/00015458.2015.11681074DOI Listing
January 2015
3 Reads

Case report: postradiation chondrosarcoma with a short latency period of 6 months.

Int J Biol Markers 2014 Dec 9;29(4):e440-4. Epub 2014 Dec 9.

3 Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu - China.

We describe a case of postradiation chondrosarcoma after basal cell carcinoma treatment. At the time he presented, the patient was a 35-year-old man who had received radiotherapy at a dose of 70 Gy for 8 weeks. Six months after radiation treatment, a rapidly growing mass at the upper right alveolar ridge of the gums, where radiation had been given, was diagnosed as chondrosarcoma. Read More

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http://dx.doi.org/10.5301/jbm.5000109DOI Listing
December 2014
3 Reads

Osteosarcomas of jaw: experience of a single centre.

J Plast Surg Hand Surg 2015 Feb 30;49(1):13-8. Epub 2014 Apr 30.

Department of Pathology, Izmir Bozyaka Training and Research Hospital , Izmir , Turkey.

Although osteosarcoma is the most common primary malignant tumour of bone, osteosarcomas of jaw are rare. In osteosarcomas of jaw, evaluating the clinicopathological factors affecting the prognosis is not easy because of different approaches to diagnosis, treatment, and follow-up. This study reviewed 14 cases of JOS that were diagnosed between 1990-2010, in terms of age, gender, site, clinical history, histopathologic type and histopathologic grade, treatment, and prognosis. Read More

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http://dx.doi.org/10.3109/2000656X.2014.909364DOI Listing
February 2015
13 Reads

Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach.

Head Neck 2015 Jun 19;37(6):815-22. Epub 2014 Jun 19.

Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.

Background: The purpose of this study was to report on the treatment outcomes of patients with postradiation second head and neck malignancies.

Methods: Fifty-seven consecutive patients with postradiation second malignancy were reviewed. Progression-free survival (PFS), overall survival (OS), and prognostic factors were analyzed. Read More

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http://dx.doi.org/10.1002/hed.23674DOI Listing
June 2015
11 Reads

Postradiation cutaneous pleomorphic rhabdomyosarcoma with extracellular collagen deposits reminiscent of so-called amianthoid fibers.

J Cutan Pathol 2014 Mar 24;41(3):316-21. Epub 2014 Jan 24.

Department of Pathology, University General Hospital, Valencia, Spain.

Rhabdomyosarcoma is a malignant mesenchymal neoplasm that rarely presents as primary skin tumor. So-called amianthoid fibers are hyalinized collagen mats that have been described in myofibroblastic tumors but not in rhabdomyosarcoma. A 65-year-old male developed a submandibular nodule 9 years after an oral squamous cell carcinoma, which had been treated with chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1111/cup.12282DOI Listing
March 2014
3 Reads

Postradiation cutaneous angiosarcoma of the breast: a diagnosis to keep in mind.

Breast J 2014 Jan-Feb;20(1):89-90. Epub 2013 Nov 18.

Dermatology Department, Hospital de Santo António dos Capuchos - Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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http://doi.wiley.com/10.1111/tbj.12215
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http://dx.doi.org/10.1111/tbj.12215DOI Listing
September 2014
13 Reads

Postradiation sarcoma from a free flap.

J Craniofac Surg 2013 Nov;24(6):2160-2

From the *Department of Plastic, Reconstructive and Aesthetic Surgery, Yeditepe Medical School, Yeditepe University; and †Department of Plastic, Reconstructive and Aesthetic Surgery, Cerrahpaşa Medical School, Istanbul University, Istanbul, Turkey.

Introduction: Postradiation sarcomas constitute approximately 0.5% to 5.5% of all sarcomas. Read More

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http://dx.doi.org/10.1097/SCS.0b013e3182a2b7bfDOI Listing
November 2013
3 Reads

Primary cardiac sarcoma after breast cancer.

BMJ Case Rep 2013 Apr 22;2013. Epub 2013 Apr 22.

Department of Medicine, Centro Hospitalar do Porto, Porto, Portugal.

Primary cardiac sarcomas are rare tumours carrying poor prognosis. Postradiation sarcoma has been reported in patients with breast, cervical and head and neck cancers. We report a case of a 56-year-old woman with stage IIA breast cancer diagnosed in 1997, submitted to mastectomy, adjuvant chemotherapy, radiotherapy and hormonotherapy. Read More

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http://dx.doi.org/10.1136/bcr-2013-008947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645808PMC
April 2013
6 Reads

Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review.

Hum Pathol 2013 Jun 26;44(6):1177-83. Epub 2013 Jan 26.

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1732, USA.

Histiocytic sarcoma (HS) is a rare neoplasm that occurs most commonly in the intestinal tract, skin, soft tissue, and lymph node. The incidence of primary central nervous system (CNS) HS is even rarer, with a total of 6 cases reported in the literature. An etiologic link has not been identified for CNS HS, and the current case of primary CNS HS is unique in that an etiologic link to prior radiation therapy is identified, associated with complex cytogenetic abnormalities in the tumor. Read More

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http://dx.doi.org/10.1016/j.humpath.2012.11.002DOI Listing
June 2013
6 Reads

Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor.

Authors:
Cyril Fisher

Semin Diagn Pathol 2013 Feb;30(1):73-84

Department of Histopathology, Royal Marsden Hospital, London, UK.

In recent years, a number of new soft tissue tumor entities have been described that occur in the skin only, or that also occur in other sites but form clinically and pathologically distinct subsets when arising in the skin and subcutaneous tissue. These include a variety of mesenchymal lineages and have variable malignant potential, although superficial malignant soft tissue tumors generally have a more favorable outcome than their more deeply located counterparts. This article reviews the clinical and pathologic features and differential diagnoses of atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelioma, myopericytoma, and perivascular epithelioid cell tumor. Read More

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http://dx.doi.org/10.1053/j.semdp.2012.01.006DOI Listing
February 2013
5 Reads

c-myc and cutaneous vascular neoplasms.

Am J Dermatopathol 2013 May;35(3):364-9

Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.

The c-myc proto-oncogene is involved in various cellular processes including cell growth, proliferation, and apoptosis. Overexpression and deregulated expression of the gene have been previously linked to several lineage-unrelated, aggressive, and poorly differentiated tumors. The expression of c-myc has also been implicated in hematopoiesis and has been shown to play a crucial role in angiogenesis via a vascular endothelial growth factor-dependent mechanism. Read More

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http://dx.doi.org/10.1097/DAD.0b013e31827aad83DOI Listing
May 2013
5 Reads

Postradiation sarcoma after radiotherapy for nasopharyngeal carcinoma.

Laryngoscope 2012 Dec 15;122(12):2695-9. Epub 2012 Oct 15.

Division of Head and Neck Surgery, Department of Surgery, University of Hong Kong Li Ka Shing Faculty of Medicine, Queen Mary Hospital, Hong Kong, China.

Objectives/hypothesis: Postradiation sarcoma (PRS) is a notorious complication after radiotherapy (RT). The prognosis is poor, and the role of surgery is not well defined. The aim of our study was to review our experience in the management of PRS after RT for nasopharyngeal carcinoma (NPC). Read More

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http://dx.doi.org/10.1002/lary.23282DOI Listing
December 2012
4 Reads

Rhabdomyosarcoma arising in a previously irradiated field: an analysis of 43 patients.

Int J Radiat Oncol Biol Phys 2013 Mar 24;85(3):598-603. Epub 2012 Jul 24.

Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas, USA.

Patients with soft tissue sarcomas that arise from previously irradiated fields have traditionally been reported to have a poor prognosis. In this report, we examined the characteristics and outcomes of patients who developed a rhabdomyosarcoma in a previously irradiated field (RMS-RIF); we hypothesize that these patients should have a better outcome compared to other postradiation soft tissue sarcomas as these tumors are chemosensitive and radiosensitive. A PubMed search of the literature from 1961-2010 yielded 33 studies with data for patients with RMS-RIF. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2012.06.011DOI Listing
March 2013
2 Reads

Positron emission tomography (PET) evaluation after initial chemotherapy and radiation therapy predicts local control in rhabdomyosarcoma.

Int J Radiat Oncol Biol Phys 2012 Nov 5;84(4):996-1002. Epub 2012 May 5.

Department of Radiation Oncology, Memorial Sloan-Kettering, New York, New York 10065, USA.

Purpose: 18-fluorodeoxyglucose positron emission tomography (PET) is already an integral part of staging in rhabdomyosarcoma. We investigated whether primary-site treatment response characterized by serial PET imaging at specific time points can be correlated with local control.

Patients And Methods: We retrospectively examined 94 patients with rhabdomyosarcoma who received initial chemotherapy 15 weeks (median) before radiotherapy and underwent baseline, preradiation, and postradiation PET. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2012.01.077DOI Listing
November 2012
7 Reads

Postradiation sarcoma: morphological findings on fine-needle aspiration with clinical correlation.

Cancer Cytopathol 2012 Oct 19;120(5):351-7. Epub 2012 Apr 19.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background: The current study was conducted to describe the clinical features and presentation, cytomorphological characteristics with histological correlation, and prognosis of patients who undergo fine-needle aspiration (FNA) for postradiation sarcoma (PRS).

Methods: A retrospective review was performed of 13 individual patients who were pooled from the FNA services of 3 academic institutions between 2001 and 2012. Cases were reviewed for the primary tumor, radiation history, latency period, and other distinguishing clinical features. Read More

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http://dx.doi.org/10.1002/cncy.21200DOI Listing
October 2012
14 Reads

Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy.

Hum Pathol 2012 Sep 8;43(9):1418-24. Epub 2012 Mar 8.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated a series of primary and locally recurrent desmoid-type fibromatoses resected at variable intervals after radiation therapy (XRT) and compared their histopathologic and immunophenotypic features with paired pathologic specimens that were obtained before radiotherapy. The morphologic characteristics of desmoid-type fibromatoses resected before and after radiotherapy were not significantly different in 7 of the 8 cases studied. Read More

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http://ac.els-cdn.com/S004681771100462X/1-s2.0-S004681771100
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http://linkinghub.elsevier.com/retrieve/pii/S004681771100462
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http://dx.doi.org/10.1016/j.humpath.2011.11.002DOI Listing
September 2012
15 Reads

Post irradiation spindle cell carcinoma of tonsillar pillar.

Case Rep Med 2011 30;2011:325193. Epub 2011 Nov 30.

Department of Pathology, Armed Forces Medical College, Pune 411040, India.

Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. Read More

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http://dx.doi.org/10.1155/2011/325193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235721PMC
August 2012
4 Reads

Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases.

Mod Pathol 2012 Jan 9;25(1):75-85. Epub 2011 Sep 9.

Dermatopathologie Bodensee, Friedrichshafen, Germany.

Postradiation cutaneous vascular lesions after treatment of breast carcinoma comprise a heterogeneous group of benign, atypical, and malignant lesions and are best regarded as points along a morphological spectrum. We analyzed a series of cutaneous angiosarcomas after treatment of breast cancer in comparison with control cases and cases of atypical vascular lesions with special emphasis on the expression and amplification of MYC. The 66 cases were divided into control cases (5), cases in which a slight vascular proliferation was seen after radiotherapy of breast cancer (12), cases of atypical vascular lesions after radiotherapy (16), cases of postradiation cutaneous angiosarcomas (25), and cases of angiosarcomas of skin and soft tissues unrelated to radiotherapy (8). Read More

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http://www.nature.com/articles/modpathol2011134
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http://dx.doi.org/10.1038/modpathol.2011.134DOI Listing
January 2012
7 Reads

Low-grade myxofibrosarcoma presenting at the site of prior high-grade disease.

J Cutan Pathol 2011 Oct 14;38(10):808-13. Epub 2011 Jul 14.

San Antonio Uniformed Services Health Education Consortium, San Antonio, TX, USA.

Myxofibrosarcoma is one of the most common soft tissue sarcomas occurring in older adults. It can arise de novo or can be radiation induced, and the term myxofibrosarcoma was originally devised to encompass a spectrum of myxoid tumors with characteristics similar to malignant fibrous histiocytoma (MFH). Confusion exists, however, regarding the distinction between microscopic grade and characteristics of myxofibrosarcoma and MFH. Read More

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http://dx.doi.org/10.1111/j.1600-0560.2011.01740.xDOI Listing
October 2011
8 Reads

[Radiation-induced fibrosarcomas rapidly appeared more than 20 years after radiation therapy for germ cell tumors: report of two cases].

No Shinkei Geka 2011 Apr;39(4):387-93

Department of Neurosurgery, Tokyo Rosai Hospital.

Radiation-induced brain tumor is a rare but serious and potentially fatal complication. We report two cases of radiation-induced fibrosarcomas which occurred more than 20 years after whole brain radiation therapy (60 Gy) for intracranial germinomas. Although both of them underwent imaging examination every year, the symptomatic sarcomas developed rapidly within a year. Read More

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April 2011
3 Reads

Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs.

Am J Surg Pathol 2011 Jan;35(1):60-9

Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Epithelioid angiosarcomas are rare aggressive neoplasms that occur most frequently in deep soft tissues. Primary cutaneous lesions are rare, and there are discrepant findings in the literature regarding their behavior. In this study, we report a series of 13 cases of primary cutaneous epithelioid angiosarcoma and analyze their clinicopathologic features. Read More

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http://dx.doi.org/10.1097/PAS.0b013e3181fee872DOI Listing
January 2011
17 Reads