1,616 results match your criteria Postradiation Sarcoma


Radioprotective effect of melatonin on expression of and genes in rat peripheral blood.

J Cancer Res Ther 2018 Dec;14(Supplement):S1070-S1075

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Ionizing radiation is a critical threat to biomolecules, especially DNA. Various combinatorial compounds have been studied to protect this biomolecule. Melatonin has been reported as a direct and indirect free radical scavenger, but in this study, we explored the effect of melatonin on assisting in DNA repair by expression of Cdkn1a and Rad50; both of these genes are involved in DNA repair signaling, induced by radiation in rat peripheral blood. Read More

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December 2018
1 Read

Pelvic Exenteration Put into Therapeutical and Palliative Perspective: It Is Worth to Try.

Indian J Surg Oncol 2018 Dec 20;9(4):552-557. Epub 2018 Jul 20.

22nd Department of Surgery, Attikon Hospital, University of Athens Medical School, 1 Rimini Str, 124 10 Chaidari, Greece.

Pelvic exenteration (PE) is one of the most drastic operations in surgical oncology, associated with severe morbidity and mortality. The objective of our study was to review our experience of PE in terms of surgical characteristics, complications, and overall survival. All patients who had PE surgery between January 1999 and December 2015 were identified. Read More

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December 2018

Assessment of swallowing function after circumferential pharyngolaryngectomy. A multicenter study by the GETTEC group.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Oct 25. Epub 2018 Oct 25.

Service d'ORL et de CCF, CHU Bichat, 75877 Paris, France.

Objective: Circumferential pharyngolaryngectomy is performed for advanced pharyngeal tumor or in a context of postradiation recurrence. Several free or pedicle flaps have been described for pharyngeal defect reconstruction, with choice at the surgeon's discretion. The aim of this study was to evaluate long-term swallowing function according to the type of flap used for reconstruction. Read More

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October 2018

Gross Total Resection of a Jugular Foramen Thyroid Medullary Metastasis via a Transjugular Transsigmoid Approach.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S424-S425. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Surgical resection of jugular foramen tumors poses a significant challenge to skull base surgeons with the selection of an appropriate surgical approach, a matter of some debate. Jugular foramen metastatic tumors may mimic paragangliomas, and in some selected cases surgical resection is needed. In this video, we demonstrate the microsurgical gross total resection of a jugular foramen tumor via a postauricular trans-jugular trans-sigmoid approach. Read More

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December 2018
3 Reads

Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma.

Cancer 2018 Oct 25. Epub 2018 Oct 25.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum tolerated doses (MTDs) of combinations of these agents with temozolomide (TMZ).

Methods: Adults with newly diagnosed glioblastoma who completed chemoradiation were eligible. Read More

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October 2018
3 Reads

Review: Proposed Methods to Improve the Survival of Adipose Tissue in Autologous Fat Grafting.

Plast Reconstr Surg Glob Open 2018 Aug 3;6(8):e1870. Epub 2018 Aug 3.

Keck School of Medicine of USC, Los Angeles, Calif., 90033.

In 2009, the American Society of Plastic Surgeons Task Force on Autologous Fat Grafting (AFG) determined that autologous fat grafting was a safe procedure with a relatively low rate of complications. This consensus opinion unleashed a wave of popularity as plastic surgeons discovered the procedures' efficacy in a wide variety of cosmetic and reconstructive indications. Frequently reported cosmetic applications include soft-tissue augmentation of breast, buttocks, hips, face, and hands, whereas reconstructive applications include adjunct for breast reconstruction contour problems, plantar fat pad improvement, and correction of various posttraumatic and surgical contour deformities. Read More

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August 2018
13 Reads

Extrascleral Tumor Extension Associated with Localized Scleral Melt following Plaque Brachytherapy for Uveal Melanoma: Clinical and Histologic Findings.

Ocul Oncol Pathol 2018 Sep 23;4(2):93-99. Epub 2017 Aug 23.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Background/aims: Our study aims to better characterize the clinical and histopathologic features of eyes with extrascleral uveal melanoma associated with scleral melt following brachytherapy.

Methods: A retrospective review was performed on patients who had undergone I (iodine-125) brachytherapy for uveal melanoma at our institution between 1992 and 2015. Patients with postradiation scleral necrosis who required enucleation were identified, and an analysis including a review of histopathology results was performed on those cases. Read More

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September 2018

Gliosarcoma: Neuroimaging and Immunohistochemical Findings.

J Neuroimaging 2018 Oct 8. Epub 2018 Oct 8.

Department of Radiology and Imaging Sciences, University of Utah Health Sciences Center, Salt Lake City, UT.

Background And Purpose: Gliosarcoma (GSC) is an intra-axial lesion which often abuts a dural margin and is composed of glial and mesenchymal elements. This lesion is considered a variant of isocitrate dehydrogenase (IDH)-wild type glioblastoma (GBM). The purpose of this study is to evaluate the imaging and molecular features of GSC in a large patient cohort. Read More

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October 2018
2 Reads

Kaposi Sarcoma and Cutaneous Angiosarcoma: Guidelines for Diagnosis and Treatment.

Actas Dermosifiliogr 2018 Dec 24;109(10):878-887. Epub 2018 Sep 24.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. Electronic address:

Kaposi sarcoma is a vascular sarcoma with 4 clinical variants: classic Kaposi sarcoma, which mainly affect the extremities of elderly patients and follows a chronic, generally indolent course; African Kaposi sarcoma; immunosuppression-associated Kaposi sarcoma; and AIDS-associated Kaposi sarcoma. Type8 human herpesvirus is the etiologic agent in all 4variants. Cutaneous angiosarcoma is a cutaneous neoplasm with a very poor prognosis. Read More

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December 2018
8 Reads

Imaging of the Knee and Surrounding Structures Following Tumor Surgery.

Semin Musculoskelet Radiol 2018 Sep 22;22(4):481-505. Epub 2018 Aug 22.

Department of Radiology, The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, United Kingdom.

Limb salvage is a key goal of tumor management around the knee, with surgical, medical, and radiologic treatment options. Primary bone and soft tissue sarcomas are optimally treated in specialist tertiary centers; however, metastatic disease is encountered in all aspects of radiologic practice, with overlap in the management strategies. Both specialist and generalist radiologists therefore need to be familiar with the expected normal appearances following these therapies and be able to recognize potential complications. Read More

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September 2018
9 Reads

Focal radiation necrosis of the brain in patients with melanoma brain metastases treated with pembrolizumab.

Cancer Med 2018 Oct 21;7(10):4870-4879. Epub 2018 Aug 21.

Department of Medical Oncology, Universitair Ziekenhuis Brussel, Brussels, Belgium.

Introduction: Up to 60% of patients with metastatic melanoma develop melanoma brain metastasis (MBM) during the course of their disease. Surgery, radiosurgery (SRS), stereotactic radiotherapy (SRT), and whole-brain radiation therapy (WBRT) or combinations of these are commonly used local treatment modalities. Inhibitory monoclonal antibodies against the CTLA-4 and PD-1 immune checkpoint receptors significantly improved the survival of metastatic melanoma patients, including patients with MBM. Read More

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October 2018

Outcome Analysis of Visual Acuity and Side Effect after Ruthenium-106 Plaque Brachytherapy for Medium-sized Choroidal Melanoma.

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):103-107

Department of Ophthalmology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

Purpose: The purpose of this study is to report on treatment outcomes for medium-sized choroidal melanoma treated with Ruthenium-106 (Ru-106) plaque brachytherapy.

Methods: A retrospective case series of 28 patients received Ru-106 brachytherapy treatment for choroidal melanoma. The prescribed tumor dose was 85 Gy to a depth of 5 mm. Read More

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September 2018

Complete resolution and periodic recurrence of multiple postradiation atypical vascular lesions.

Australas J Dermatol 2018 Aug 15. Epub 2018 Aug 15.

Oncologic and Preventative Dermatology Department, San Gallicano Dermatological Institute, Rome, Italy.

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August 2018
2 Reads

Persistent Oxidative Stress in Vestibular Schwannomas After Stereotactic Radiation Therapy.

Otol Neurotol 2018 Oct;39(9):1184-1190

Department of Otolaryngology-Head and Neck Surgery.

Objective: Stereotactic radiation therapy is increasingly used to treat vestibular schwannomas (VSs) primarily and to treat tumor remnants following microsurgery. Little data are available regarding the effects of radiation on VS cells. Tyrosine nitrosylation is a marker of oxidative stress following radiation in malignant tumors. Read More

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October 2018
7 Reads

Normalized Subtraction of Serial Brain Magnetic Resonance Images and Fludeoxyglucose-Positron Emission Tomography Images for Tumor Treatment Monitoring: Case Report and Method Description.

J Clin Imaging Sci 2018 28;8:25. Epub 2018 Jun 28.

Department of Radiology, Saint Louis University, Saint Louis, Missouri, United States.

A 60-year-old Caucasian male with a long history of cigarette smoking was diagnosed with epidermal growth factor receptor-mutation negative lung adenocarcinoma. The single cerebral metastasis in the right frontal lobe was treated with stereotactic radiosurgery and systemic chemotherapies. Normalized subtraction (NS) method was used to evaluate the serial brain magnetic resonance (MR) and fludeoxyglucose-positron emission tomography (FDG-PET) findings retrospectively, and the potential benefit of concurrent NS of serial MR images (MRIs) and PET images was demonstrated. Read More

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Secondary spindle cell sarcoma following external beam radiotherapy for prostate cancer: a rare but devastating complication.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Urology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

We report a case of rapidly growing sarcoma that resulted in mortality only 6 years after radiotherapy for low-grade prostate cancer.At the age of 69 years and a prostate-specific antigen (PSA) that had risen to 9.0 µg/L, transrectal ultrasound-guided biopsy of the prostate found a single core of Gleason 3+3 disease involving 4 mm of a 10 mm core. Read More

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July 2018
3 Reads

Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer.

Int J Radiat Oncol Biol Phys 2018 Nov 28;102(4):1029-1035. Epub 2018 Jun 28.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

Purpose: Patients with p16/human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma have a favorable outcome after treatment. In this group of patients who could have a long life expectancy, the optimal surveillance strategy and modality is not well established. We aim to determine the ability of a negative postradiation positron emission tomography (PET)/computed tomography scan to predict the risk of subsequent relapse in these patients. Read More

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November 2018
17 Reads

Persistent disruption of lateral junctional complexes and actin cytoskeleton in parotid salivary glands following radiation treatment.

Am J Physiol Regul Integr Comp Physiol 2018 Oct 13;315(4):R656-R667. Epub 2018 Jun 13.

Cancer Biology Graduate Interdisciplinary Program, University of Arizona , Tucson, Arizona.

Xerostomia and hyposalivation are debilitating side effects for patients treated with ionizing radiation for head and neck cancer. Despite technological advances, collateral damage to the salivary glands remains a significant problem for patients and severely diminishes their quality of life. During the wound healing process, restoration of junctional contacts is necessary to maintain polarity, structural integrity, and orientation cues for secretion. Read More

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October 2018
2 Reads

The Phosphorylated ATM Immunofluorescence Assay: A High-performance Radiosensitivity Assay to Predict Postradiation Therapy Overreactions.

Int J Radiat Oncol Biol Phys 2018 Jul 4;101(3):690-693. Epub 2018 Apr 4.

Department of Radiobiology, Cancer Center of Lyon, Unite Mixte de Recherche Inserm 1052, Conseil National de la Recherche Scientifique 5286 Centre Léon Bérard, Lyon, France.

Purpose: The ability to identify, before treatment, those patients who will overreact to radiation therapy would have sound positive clinical implications. By focusing on DNA double-strand breaks recognition and repair proteins after irradiation, we recently demonstrated that the maximal number of phosphorylated ATM (pATM) nuclear foci in the first hour (pATMmax) after ex vivo irradiation correlated with postradiation therapy toxicity severity. We performed additional analyses of our whole collection of fibroblast lines to refine the predictive performance of our assay. Read More

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July 2018
12 Reads

Metallic Nanoislands on Graphene for Monitoring Swallowing Activity in Head and Neck Cancer Patients.

ACS Nano 2018 Jun 8. Epub 2018 Jun 8.

Department of NanoEngineering , University of California, San Diego , 9500 Gilman Drive, Mail Code 0448 , La Jolla , California 92093-0448 , United States.

There is a need to monitor patients with cancer of the head and neck postradiation therapy, as diminished swallowing activity can result in disuse atrophy and fibrosis of the swallowing muscles. This paper describes a flexible strain sensor comprising palladium nanoislands on single-layer graphene. These piezoresistive sensors were tested on 14 disease-free head and neck cancer patients with various levels of swallowing function: from nondysphagic to severely dysphagic. Read More

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June 2018
4 Reads
12.881 Impact Factor

Management of a late breast implant rupture in the setting of previous radiation.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Plastic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Management of ruptured breast implants is scarcely discussed in the literature, especially in the setting of previous breast cancer and radiation. The authors present an uncommon presentation of late breast implant rupture with seroma and history of prior radiation. It is important to acknowledge the increased risk of wound healing complications in patients who are several years' postradiation therapy for breast cancer and should be an important factor when discussing treatment options with the patient. Read More

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June 2018
5 Reads

CIED malfunction in patients receiving radiation is a rare event that could be detected by remote monitoring.

J Cardiovasc Electrophysiol 2018 Sep 22;29(9):1268-1275. Epub 2018 Jun 22.

Department of Cardiology, University of Rochester Medical Center, Rochester, NY, USA.

Introduction: An increasing number of patients with cardiac devices require radiation therapy for treatment of a variety of cancers. This study aimed to identify the incidence and predictors of cardiac implantable electronic devices (CIED) malfunction in a real-world population that has received radiation therapy.

Methods: This retrospective cohort study included 109 adult patients who received radiation therapy at the University of Rochester Medical Center, Radiation Oncology Department, between 2000 and 2015. Read More

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September 2018

Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome.

Case Rep Pathol 2018 24;2018:5947870. Epub 2018 Apr 24.

Department of Pathology, UAB, Birmingham, AL, USA.

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms. Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation. We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy. Read More

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April 2018
2 Reads

Follicular dendritic cell sarcoma presenting as a painless lump in the parotid.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.

Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of the antigen presenting cells of the immune system. The majority occur in lymph nodes but around 30% can occur extranodally including in the spleen, lungs, head and neck and liver. We present an unusual case of an FDCS of the parotid gland in a 51-year-old woman with a history of Hodgkin's lymphoma treated with combination chemotherapy and modified mantle radiotherapy. Read More

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May 2018
3 Reads

Exploratory Analysis of Brigatinib Activity in Patients With Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer and Brain Metastases in Two Clinical Trials.

J Clin Oncol 2018 Sep 16;36(26):2693-2701. Epub 2018 May 16.

D. Ross Camidge, University of Colorado Cancer Center, Aurora, CO; Dong-Wan Kim, Seoul National University Hospital; Myung-Ju Ahn, Samsung Medical Center; Dae Ho Lee, Asan Medical Center, Seoul, South Korea; Marcello Tiseo, University Hospital of Parma, Parma, Italy; Corey J. Langer, University of Pennsylvania, Philadelphia, PA; Alice T. Shaw, Massachusetts General Hospital, Boston; William Reichmann, Jeff Haney, Tim Clackson, and David Kerstein, ARIAD Pharmaceuticals, Cambridge, MA; Rudolf M. Huber, University Hospital of Munich, Munich, Germany; Maximilian J. Hochmair, Otto Wagner Hospital, Vienna, Austria; Lyudmila A. Bazhenova and Kathryn A. Gold, University of California San Diego Moores Cancer Center, La Jolla; Sai-Hong Ignatius Ou, University of California Irvine School of Medicine, Irvine, CA; Howard L. West, Swedish Cancer Institute, Seattle, WA; and Scott N. Gettinger, Yale Cancer Center, New Haven, CT.

Purpose In patients with crizotinib-treated, anaplastic lymphoma kinase gene ( ALK)-rearranged non-small-cell lung cancer (ALK-positive NSCLC), initial disease progression often occurs in the CNS. We evaluated brigatinib, a next-generation ALK inhibitor, in patients with ALK-positive NSCLC with brain metastases. Patients and Methods Patients with ALK-positive NSCLC received brigatinib (90 to 240 mg total daily) in a phase I/II trial (phI/II; ClinicalTrials. Read More

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September 2018
10 Reads

Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer.

Head Neck 2018 Jul 13;40(7):1400-1405. Epub 2018 May 13.

Department of Otolaryngology - Head and Neck Surgery, Sanford University of South Dakota Medical Center, Sanford Research, Sioux Falls, South Dakota.

Background: Topical superoxide dismutase (SOD) has been shown to decrease postradiation fibrosis in some cancers but has not demonstrated an effect in patients with head and neck cancer. The purpose of this study was to determine if topical SOD is an effective treatment for postradiation neck fibrosis.

Methods: This was a randomized prospective blinded clinical study of topical SOD versus placebo for the treatment of neck fibrosis. Read More

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Use of a biological mesh for the treatment of perineal fistula following radical colorectal resection.

Clin Case Rep 2018 May 30;6(5):926-929. Epub 2018 Mar 30.

1st Surgical Department General Hospital of Athens "G. Gennimatas" Athens Greece.

Patients with postradiation therapy for malignancies and/or extensive colorectal surgery are prone to the development of enteroperineal fistulas. Application of biological meshes may prove beneficial in treating complicated enteroperineal fistulas as they provide a stable ground for closing pelvic defects even in contaminated fields. Read More

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May 2018
1 Read

Role of Recursive Partitioning Analysis and Graded Prognostic Assessment on Identifying Non-Small Cell Lung Cancer Patients with Brain Metastases Who May Benefit from Postradiation Systemic Therapy.

Chin Med J (Engl) 2018 May;131(10):1206-1213

Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

Background: The role of postradiation systemic therapy in non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) was controversial. Thus, we explored the role of Radiation Therapy Oncology Group recursive partitioning analysis (RTOG-RPA) and graded prognostic assessment (GPA) in identifying population who may benefit from postradiation systemic therapy.

Methods: The clinical data of NSCLC patients with documented BM from August 2007 to April 2015 of two hospitals were studied retrospectively. Read More

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May 2018
4 Reads
1.020 Impact Factor

Changes in the Common Carotid Artery after Radiotherapy: Wall Thickness, Calcification, and Atherosclerosis.

J Clin Neurol 2018 Jan;14(1):35-42

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Purpose: Since the long-term survival rate has improved in laryngeal cancer patients who receive radiotherapy, concerns about postradiation complications (including carotid atherosclerosis) have increased. We followed changes in the common carotid artery (CCA) after radiotherapy and identified the underlying risk factors.

Methods: Consecutive patients with laryngeal cancer who underwent radiotherapy between January 1999 and December 2009 and who had received computed tomography (CT) both pre- and postradiotherapy were enrolled. Read More

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January 2018
10 Reads

Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model.

Ann Surg Treat Res 2018 Apr 26;94(4):174-182. Epub 2018 Mar 26.

Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey.

Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP.

Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Read More

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April 2018
5 Reads

Imaging of Posttreatment Salivary Gland Tumors.

Neuroimaging Clin N Am 2018 May;28(2):199-208

Department of Radiology, Michigan State University, Michigan State University Health Team, 846 Service Road, East Lansing, MI 48824, USA.

The aim of this study is to review the imaging appearance of posttreatment salivary gland tumors. The authors discuss the imaging appearance of parotidectomy and reconstructive surgery of parotid defects. Imaging is important to diagnose tumor recurrence and also assess for complications related to surgery, such as a sialocele, fluid collection, hematoma, pseudoaneurysm, and graft stenosis. Read More

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May 2018
4 Reads
1.290 Impact Factor

Postradiation hypothyroidism in head and neck cancers: A Department of Veterans Affairs single-institution case-control dosimetry study.

Med Dosim 2018 Mar 23. Epub 2018 Mar 23.

Department of Radiation Oncology, VA Long Beach Healthcare System, Long Beach, CA; Department of Radiation Oncology, University of California, Los Angeles, CA. Electronic address:

We performed a case-control study to characterize the dose-volume relationship and other variables leading to hypothyroidism after head and neck (H&N) cancer radiation therapy (RT) in a homogenous Veterans Affairs (VA) population. All records of patients receiving RT for various H&N cancers at a single VA medical center between 2007 and 2013 (n = 143) were screened for post-RT thyroid stimulating hormone (TSH) levels (n = 77). The thyroid gland was contoured on each slice of the planning computed tomography scan when available (hypothyroid: n = 18; euthyroid > 2 years: n = 16), and dose-volume histograms based on physical dose and biologically equivalent dose (BED) were compared systematically to find the significant dose-volume thresholds that distinguish the patients who developed clinical hypothyroidism. Read More

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[Late complications of choroidal melanoma brachytherapy and possibility of their prevention].

Vestn Oftalmol 2018 ;134(1):4-11

Городская клиническая больница им. С.П. Боткина филиал No1 (офтальмологическая клиника), Мамоновский пер., 7, Москва, 123001, Российская Федерация.

Complications and the frequency of their occurrence as the criteria of eye preservation after brachytherapy (BT) are presented in literature with inconsistencies due to the assessment being done after varied follow-up periods (1 month to 5-10 years). The evaluation of complications occurring after applying radioiodine can be found in literature. The complications after BT beta particle emitting ophthalmic applicators are seldom discussed in articles. Read More

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January 2018
3 Reads

What Is the Effect of High-dose Radiation on Bone in Patients With Sacral Chordoma? A CT Study.

Clin Orthop Relat Res 2018 Mar;476(3):520-528

O. van Wulfften Palthe, Massachusetts General Hospital, Boston, MA, USA K.-W. Jee, Y.-L. E. Chen, Department of Radiation Oncology, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. A. M. Bramer, Department of Orthopaedic Surgery, Academic Medical Center, Amsterdam, Amsterdam, The Netherlands F. J. Hornicek, Harvard Medical School, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. H. Schwab, Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Spine Surgery Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.

Background: Effects of high-dose radiation using protons and photons on bone are relatively unexplored, but high rates of insufficiency fractures are reported, and the causes of this are incompletely understood. Imaging studies with pre- and postradiation scans can help one understand the effect of radiation on bone.

Questions/purposes: The purpose of this study was to assess the effects of high-dose radiation on the trabecular density of bone in the sacrum using CT-derived Hounsfield units (HU). Read More

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March 2018
1 Read

Emphasis on Systemic Therapy in Women With Pelvic Bone Metastasis at Time of Diagnosis of Cervical Cancer.

Am J Clin Oncol 2018 Mar 8. Epub 2018 Mar 8.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology.

Objective: Cervical cancer presenting with metastases to the bony pelvis is rare. No available literature addresses the treatment and prognosis of these patients. Our objective was to review our experience treating women with this rare presentation. Read More

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March 2018
5 Reads

Parosteal osteosarcoma of mandible: A rare case report.

J Cancer Res Ther 2018 Jan-Mar;14(2):471-474

Department of Oral Medicine and Radiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

With the exception of multiple myelomas, osteosarcoma is the most frequently occurring primary malignant bone tumor with an overall incidence of 1:100,000/year. It has greatest predilection for the metaphyses, most frequently femur and tibia. However, osteosarcomas affecting the craniofacial bones are infrequent. Read More

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August 2018
6 Reads

Preoperative Stereotactic Radiosurgery of Brain Metastases: Preliminary Results.

Cureus 2017 Dec 26;9(12):e1987. Epub 2017 Dec 26.

Department of Neurotrauma, N.N. Burdenko National Medical Research Center for Neurosurgery.

Introduction:  Preoperative stereotactic radiosurgery (pre-SRS) is a recent advancement in the strategy for brain metastasis (BM) management, and available data demonstrate the advantages of pre-SRS before postoperative radiation treatment, including lower rates of local toxicity, leptomeningeal progression, and a high percentage of local control. The authors presented the results of pre-SRS in patients with BM.

Materials And Methods: Nineteen patients with BM (11 female and eight male) have been treated at N. Read More

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December 2017
2 Reads

Endoscope-assisted conservative resection and reconstruction in recurrent subglottic carcinoma.

Head Neck 2018 Apr 5;40(4):E36-E39. Epub 2018 Feb 5.

Department of Head and Neck Surgical Oncology, VPS Lakeshore Hospital, Cochin, Kerala, India.

Background: Very few cases of conservative laryngectomy in recurrent carcinoma of subglottis postradiotherapy have been reported. Technical aspects of conservative resection and reconstruction in subglottic carcinoma have not been well described.

Methods: Herein, we present a case of recurrent carcinoma of subglottis for which conservative resection with adequate margins was done with endoscope assistance and defect reconstructed by buccal mucosa, conchal cartilage, and temporoparietal free flap. Read More

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April 2018
1 Read

Clinical Characteristics and Associated Systemic Diseases in Patients With Esophageal "Absent Contractility"-A Clinical Algorithm.

J Clin Gastroenterol 2018 Jan 19. Epub 2018 Jan 19.

Digestive Disease Institute, Cleveland Clinic.

Goals: This study was carried out to assess the clinical characteristics and associated systemic diseases seen in patients diagnosed with absent contractility as per the Chicago Classification version 3.0, allowing us to propose a diagnostic algorithm for their etiologic testing.

Background: The Chicago Classification version 3. Read More

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January 2018
11 Reads

Quadruple Neoplasms following Radiation Therapy for Congenital Bilateral Retinoblastoma.

Ocul Oncol Pathol 2017 Dec 6;4(1):33-37. Epub 2017 Jul 6.

Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Purpose: The aim of this study was to describe a 34-year-old male with hereditary bilateral retinoblastoma treated with radiotherapy as a child who developed 4 distinct tumors within the radiation field.

Methods: A 34-year-old male with bilateral retinoblastoma status postradiation therapy and recurrence requiring enucleation presented with left-eye visual acuity changes. Magnetic resonance imaging demonstrated a left orbital mass and a right parasellar complex lobulated mass (right sphenoid and right cavernous sinus). Read More

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December 2017
10 Reads

Postradiation Synovial Sarcoma of the Common Bile Duct: A Previously Unreported Anatomic Site.

Int J Surg Pathol 2018 Aug 16;26(5):469-474. Epub 2018 Jan 16.

1 Instituto Nacional de Cancerología, México City, México.

Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11. Read More

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August 2018
2 Reads

Mesenchymal tumors of the prostate.

Authors:
Jesse K McKenney

Mod Pathol 2018 Jan;31(S1):S133-142

Robert J Tomsich Pathology and Laboratory Medicine Institute, Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.

Mesenchymal tumors of the prostate are rare but often cause considerable diagnostic difficulty when encountered. These may be either benign or malignant and can arise within the prostate gland or in adjacent tissues. This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth muscle neoplasms (leiomyoma and leiomyosarcoma), gastrointestinal stromal tumor, schwannoma, rhabdomyosarcoma, sarcomatoid carcinoma, postradiation sarcoma, and mixed epithelial stromal tumor of the seminal vesicle. Read More

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January 2018
12 Reads

Serial magnetic resonance imaging evaluations of irradiated superior cervical sympathetic ganglia: Not every retropharyngeal enlarging mass is a sign of malignancy.

Eur J Radiol 2018 Jan 16;98:126-129. Epub 2017 Nov 16.

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Republic of Korea.

Introduction: To describe serial changes in irradiated superior cervical sympathetic ganglia (SCSGs) on MRI (magnetic resonance imaging) evaluation in patients with head and neck squamous cell carcinoma (HNSCC) and to find the features differentiating them from the metastatic retropharyngeal lymph nodes.

Materials And Methods: This retrospective study evaluated 52 consecutive patients with definitive radiotherapy with/without chemotherapy for pathologically confirmed HNSCC and pre- and postradiation MRI follow-up evaluations. MR images of SCSGs were analyzed including enhancement pattern, margin, and the presence of intraganglionic hypointensity. Read More

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January 2018
8 Reads

The use of cone beam computed tomography and three dimensional printing technology in the restoration of a maxillectomy patient using a dental implant retained obturator.

J Indian Prosthodont Soc 2017 Oct-Dec;17(4):406-411

Prosthodontist, Crete Implants, Private Dental Practice Heraklion, Crete, Greece.

This case report presents an alternative method for fabricating an obturator for patients that develop xerostomia and mild trismus following radiation to the Head and Neck region. Multiple initial impression stages are avoided leading to less irritation to soft tissues and less discomfort to the patient. A 69-year-old male patient was referred to our dental practice by the Maxillofacial Surgery Department of the local General Hospital. Read More

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April 2017
4 Reads

Differentiation of residual/recurrent gliomas from postradiation necrosis with arterial spin labeling and diffusion tensor magnetic resonance imaging-derived metrics.

Neuroradiology 2018 Feb 7;60(2):169-177. Epub 2017 Dec 7.

Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, 13551, Egypt.

Purpose: The aim of this study is to differentiate recurrent/residual gliomas from postradiation changes using arterial spin labeling (ASL) perfusion and diffusion tensor imaging (DTI)-derived metrics.

Methods: Prospective study was conducted upon 42 patients with high-grade gliomas after radiotherapy only or prior to other therapies that underwent routine MR imaging, ASL, and DTI. The tumor blood flow (TBF), fractional anisotropy (FA), and mean diffusivity (MD) of the enhanced lesion and related edema were calculated. Read More

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February 2018
4 Reads

Management of radiation-induced rectovesical fistula in a woman using ileum: A case report and review of the literature.

Medicine (Baltimore) 2017 Nov;96(46):e8553

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Background: Radiation-induced rectovesical fistulas (RVFs) require the most demanding treatment. We presented a rare case of postradiation RVF in a woman repaired with ileum.

Case Presentation: A 49-year-old women was referred to our department for fecaluria and dysuria after radiation for cervical cancer. Read More

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November 2017
5 Reads

Use of Acellular Dermal Matrix in Craniosynostosis.

Authors:
Anil Madaree

J Craniofac Surg 2018 Jan;29(1):126-129

Department of Plastic and Reconstructive Surgery, Inkosi Albert Luthuli Central Hospital, Nelson R Mandela School of Medicine, University of Kwazulu Natal, Durban, South Africa.

In craniofacial surgery, a wide spectrum of pathological conditions are usually treated. The aetiology of these could be congenital, traumatic, infective, post-tumor resection, postradiation, autoimmune, iatrogenic, or other miscellaneous conditions. The surgical approach for the procedures is usually via a coronal incision. Read More

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January 2018
11 Reads

Solitary Orbital Metastasis in Carcinoma Esophagus: Findings on Serial 18F-FDG PET/CT Scans.

Clin Nucl Med 2018 Jan;43(1):19-22

Orbital metastasis is an uncommon and atypical presentation of recurrent esophageal cancer that has been only seldom reported in literature. F-FDG PET/CT is routinely performed for staging and response assessment in patients with esophageal carcinoma. This case demonstrates use of follow-up FDG PET/CT scans in characterizing solitary metastatic disease in orbit and in evaluating response to therapy. Read More

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January 2018

High-Dose (2.5 mg) Intravitreal Bevacizumab as Rescue Therapy for Persistent Postradiation Cystoid Macular Edema.

Ocul Oncol Pathol 2017 Sep 27;3(3):168-175. Epub 2017 Jan 27.

Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Background/aims: To investigate the efficacy of intravitreal high-dose (2.5 mg/0.1 mL) bevacizumab as rescue therapy for postradiation cystoid macular edema (CME) resistant to standard-dose (1. Read More

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September 2017
4 Reads

Spontaneous Remission of Severe Systemic Langerhans Cell Histiocytosis with Bladder Involvement: A Case Study.

Case Rep Oncol 2017 Sep-Dec;10(3):876-884. Epub 2017 Oct 5.

Department of Gynecology and Gynecological Oncology, Hospital for Women, University Hospital Basel, Basel, Switzerland.

Background: The clinical presentation of Langerhans cell histiocytosis (LCH) is heterogeneous ranging from single-organ involvement to systemic disease causing substantial morbidity and mortality. We describe an unusual course of severe multisystem LCH with spontaneous remission.

Case Presentation: We report on a 45-year-old Caucasian woman with cervical cancer, FIGO stage IVB. Read More

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October 2017
10 Reads