180 results match your criteria Postradiation Sarcoma


Systematic review of charged-particle therapy for chordomas and sarcomas of the mobile spine and sacrum.

Neurosurg Focus 2021 May;50(5):E17

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective: Long-term local control in patients with primary chordoma and sarcoma of the spine and sacrum is increasingly reliant upon en bloc resection with negative margins. At many institutions, adjuvant radiation is recommended; definitive radiation is also recommended for the treatment of unresectable tumors. Because of the high off-target radiation toxicities associated with conventional radiotherapy, there has been growing interest in the use of proton and heavy-ion therapies. Read More

View Article and Full-Text PDF

Postradiation Fractures after Combined Modality Treatment in Extremity Soft Tissue Sarcomas.

Sarcoma 2021 15;2021:8877567. Epub 2021 Mar 15.

Department of Surgery, Orthopedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065, USA.

Soft tissue sarcoma (STS) of the extremities is typically treated with limb-sparing surgery and radiation therapy; with this treatment approach, high local control rates can be achieved. However, postradiation bone fractures, fractures occurring in the prior radiation field with minimal or no trauma, are a serious late complication that occurs in 2-22% of patients who receive surgery and radiation for STS. Multiple risk factors for sustaining a postradiation fracture exist, including high radiation dose, female sex, periosteal stripping, older age, femur location, and chemotherapy administration. Read More

View Article and Full-Text PDF

Radiation-induced Supratentorial Osteosarcoma Following Curative Treatment of Infratentorial Ependymoma in a Child.

J Pediatr Neurosci 2020 Jul-Sep;15(3):304-307. Epub 2020 Nov 6.

Department of Neurosurgery, Shatabdi Hospital Phase 2, King George Medical University, Lucknow, Uttar Pradesh, India.

The development of secondary neoplasms following therapeutic cranial irradiation is rare and quite often lethal. Meningiomas, sarcomas, and high-grade gliomas are the most common tumors that manifest as a result of radiation therapy. We report the case of an 11-year-old child who presented with symptoms of supratentorial space-occupying lesion 7 years after curative surgery and cranial irradiation for a posterior fossa ependymoma. Read More

View Article and Full-Text PDF
November 2020

Treatment options in femoral radiation fractures following soft tissue sarcoma: Incidence, risk factors, failures and flowchart of treatment.

Injury 2020 Dec 24. Epub 2020 Dec 24.

Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.

Introduction: The femur is the most frequent involved site by post-attinic fractures. The appropriate treatment of pathological fractures after radiotherapy is still controversial as they are associated with a high risk of delayed consolidation and non-union. Authors review a single Center series of pathological fractures after radiation therapy in patients affected by soft tissue sarcomas analyzing incidence, risk factors, failure rate and proposing a flow chart of treatment of postattinic fractures of the femur. Read More

View Article and Full-Text PDF
December 2020

Primary Undifferentiated Pericardial Sarcoma after Radiоtherapy for Hodgkin Lymphoma.

Case Rep Oncol 2020 Sep-Dec;13(3):1075-1081. Epub 2020 Sep 7.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Various types of sarcomas arise as a result of postradiation chronic fibrous pericarditis. A primary undifferentiated spindle cell pericardial sarcoma is a rare type of sarcoma after radiotherapy. The risk of sarcoma increases with time after treatment of cancer. Read More

View Article and Full-Text PDF
September 2020

Irradiated Skeletal Muscle Cells Mimicking Those of Atypical Fibroxanthoma on Mohs Frozen Sections.

Am J Dermatopathol 2021 May;43(5):362-364

Bennett Surgery Center, Santa Monica, CA.

Abstract: Radiation can induce changes to skeletal muscle cells that may mimic and thus be confused with cells of atypical fibroxanthoma (AFX), pleomorphic dermal sarcoma, spindle cell squamous cell carcinoma, and other spindle soft-tissue tumors. An 80-year-old White man presented for Mohs micrographic surgery of an AFX on the left lateral neck. The medical history was notable for a tongue squamous cell carcinoma 9 years before that had been treated with wide local excision, left neck dissection, and radiation to the oral cavity and left neck. Read More

View Article and Full-Text PDF

Radiation Disrupts the Protective Function of the Spinal Meninges in a Mouse Model of Tumor-induced Spinal Cord Compression.

Clin Orthop Relat Res 2021 Jan;479(1):163-176

T. Shimizu, S. Demura, S. Kato, K. Shinmura, N. Yokogawa, N. Yonezawa, N. Oku, R. Kitagawa, M. Handa, R. Annen, T. Nojima, H. Tsuchiya, Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Background: Recent advances in multidisciplinary treatments for various cancers have extended the survival period of patients with spinal metastases. Radiotherapy has been widely used to treat spinal metastases; nevertheless, long-term survivors sometimes undergo more surgical intervention after radiotherapy because of local tumor relapse. Generally, intradural invasion of a spinal tumor seldom occurs because the dura mater serves as a tissue barrier against tumor infiltration. Read More

View Article and Full-Text PDF
January 2021

Dermatoscopic and ultra-high frequency ultrasound evaluation in cutaneous postradiation angiosarcoma.

J Eur Acad Dermatol Venereol 2020 Nov 8;34(11):e741. Epub 2020 Jun 8.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

View Article and Full-Text PDF
November 2020

Radiation-induced undifferentiated pleomorphic sarcoma of the breast.

BMJ Case Rep 2020 Feb 10;13(2). Epub 2020 Feb 10.

General Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA

Breast sarcoma is a rare form of malignancy that arises from connective tissue within the breast, comprising less than 5% of all sarcomas. They develop as primary tumours or as secondary following radiation therapy. Diagnosis can be challenging as breast sarcomas are often asymptomatic and resemble benign breast tissue changes. Read More

View Article and Full-Text PDF
February 2020

Characteristics of atypical postradiation vascular proliferation: A retrospective review of 193 patients.

J Am Acad Dermatol 2020 Nov 25;83(5):1447-1450. Epub 2019 Oct 25.

Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Cutaneous Oncology, Dana Farber Cancer Institute, Boston, Massachusetts. Electronic address:

View Article and Full-Text PDF
November 2020

Rectotumoral fistula formation occurring more than 5 years after carbon ion radiotherapy for sacral chordoma: A case report.

Mol Clin Oncol 2019 May 5;10(5):487-491. Epub 2019 Mar 5.

Musculoskeletal Oncology Service, Osaka International Cancer Institute, Osaka, Osaka 541-8567, Japan.

Chordoma is a rare tumor that originates from the notochord. Half of chordomas involve the sacral region. Surgery is considered to be the standard treatment for sacral chordoma. Read More

View Article and Full-Text PDF

Undifferentiated sarcoma of the pericardium after radiation therapy for Hodgkin's lymphoma.

Ter Arkh 2018 Aug;90(8):69-73

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Moscow, Russia.

Primary sarcomas of the pericardium are extremely rare malignant tumors of the heart. The incidence of sarcoma increases after radiation therapy in the field of breast. The specific features of this case report are the difficulties in diagnostics of undifferentiated spindle-cell sarcoma of the pericardium and the connection between the disease and the radiation therapy for Hodgkin's lymphoma. Read More

View Article and Full-Text PDF

Kaposi Sarcoma and Cutaneous Angiosarcoma: Guidelines for Diagnosis and Treatment.

Actas Dermosifiliogr 2018 Dec 24;109(10):878-887. Epub 2018 Sep 24.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. Electronic address:

Kaposi sarcoma is a vascular sarcoma with 4 clinical variants: classic Kaposi sarcoma, which mainly affect the extremities of elderly patients and follows a chronic, generally indolent course; African Kaposi sarcoma; immunosuppression-associated Kaposi sarcoma; and AIDS-associated Kaposi sarcoma. Type8 human herpesvirus is the etiologic agent in all 4variants. Cutaneous angiosarcoma is a cutaneous neoplasm with a very poor prognosis. Read More

View Article and Full-Text PDF
December 2018

Secondary spindle cell sarcoma following external beam radiotherapy for prostate cancer: a rare but devastating complication.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Urology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

We report a case of rapidly growing sarcoma that resulted in mortality only 6 years after radiotherapy for low-grade prostate cancer.At the age of 69 years and a prostate-specific antigen (PSA) that had risen to 9.0 µg/L, transrectal ultrasound-guided biopsy of the prostate found a single core of Gleason 3+3 disease involving 4 mm of a 10 mm core. Read More

View Article and Full-Text PDF

Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome.

Case Rep Pathol 2018 24;2018:5947870. Epub 2018 Apr 24.

Department of Pathology, UAB, Birmingham, AL, USA.

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms. Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation. We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy. Read More

View Article and Full-Text PDF

Follicular dendritic cell sarcoma presenting as a painless lump in the parotid.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.

Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of the antigen presenting cells of the immune system. The majority occur in lymph nodes but around 30% can occur extranodally including in the spleen, lungs, head and neck and liver. We present an unusual case of an FDCS of the parotid gland in a 51-year-old woman with a history of Hodgkin's lymphoma treated with combination chemotherapy and modified mantle radiotherapy. Read More

View Article and Full-Text PDF

Parosteal osteosarcoma of mandible: A rare case report.

J Cancer Res Ther 2018 Jan-Mar;14(2):471-474

Department of Oral Medicine and Radiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

With the exception of multiple myelomas, osteosarcoma is the most frequently occurring primary malignant bone tumor with an overall incidence of 1:100,000/year. It has greatest predilection for the metaphyses, most frequently femur and tibia. However, osteosarcomas affecting the craniofacial bones are infrequent. Read More

View Article and Full-Text PDF

Quadruple Neoplasms following Radiation Therapy for Congenital Bilateral Retinoblastoma.

Ocul Oncol Pathol 2017 Dec 6;4(1):33-37. Epub 2017 Jul 6.

Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Purpose: The aim of this study was to describe a 34-year-old male with hereditary bilateral retinoblastoma treated with radiotherapy as a child who developed 4 distinct tumors within the radiation field.

Methods: A 34-year-old male with bilateral retinoblastoma status postradiation therapy and recurrence requiring enucleation presented with left-eye visual acuity changes. Magnetic resonance imaging demonstrated a left orbital mass and a right parasellar complex lobulated mass (right sphenoid and right cavernous sinus). Read More

View Article and Full-Text PDF
December 2017

Postradiation Synovial Sarcoma of the Common Bile Duct: A Previously Unreported Anatomic Site.

Int J Surg Pathol 2018 Aug 16;26(5):469-474. Epub 2018 Jan 16.

1 Instituto Nacional de Cancerología, México City, México.

Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11. Read More

View Article and Full-Text PDF

Mesenchymal tumors of the prostate.

Authors:
Jesse K McKenney

Mod Pathol 2018 01;31(S1):S133-142

Robert J Tomsich Pathology and Laboratory Medicine Institute, Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.

Mesenchymal tumors of the prostate are rare but often cause considerable diagnostic difficulty when encountered. These may be either benign or malignant and can arise within the prostate gland or in adjacent tissues. This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth muscle neoplasms (leiomyoma and leiomyosarcoma), gastrointestinal stromal tumor, schwannoma, rhabdomyosarcoma, sarcomatoid carcinoma, postradiation sarcoma, and mixed epithelial stromal tumor of the seminal vesicle. Read More

View Article and Full-Text PDF
January 2018

Unusual Presentation of Postradiation Sarcoma With Subsequent Intestinal Metastasis Revealed by 18F-FDG PET/CT.

Clin Nucl Med 2017 Oct;42(10):e438-e440

From the *Department of Nuclear Medicine, and †Division of Radiology Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.

Radiation-related sarcoma is a rare but serious complication for patients after receiving radiation therapy initially for their primary malignancy. However, it usually takes several years and needs enough in-field radiation dose to develop this sarcoma. We describe a 60-year-old man with right axillary sarcoma revealed by whole-body F-FDG PET/CT 1 year after chemoradiotherapy, which presented ultrashort latency period and did not match the consensus definition of radiation-related sarcoma. Read More

View Article and Full-Text PDF
October 2017

Pathological characteristics of spine metastases treated with high-dose single-fraction stereotactic radiosurgery.

Neurosurg Focus 2017 Jan;42(1):E7

Departments of1Radiation Oncology.

OBJECTIVE Spine radiosurgery is increasingly being used to treat spinal metastases. As patients are living longer because of the increasing efficacy of systemic agents, appropriate follow-up and posttreatment management for these patients is critical. Tumor progression after spine radiosurgery is rare; however, vertebral compression fractures are recognized as a more common posttreatment effect. Read More

View Article and Full-Text PDF
January 2017

Isolated Unilateral Tongue Atrophy: A Possible Late Complication of Juxta Cephalic Radiation Therapy.

Am J Case Rep 2016 Jul 26;17:535-7. Epub 2016 Jul 26.

Department of Neurology, The School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.

BACKGROUND Isolated unilateral hypoglossal nerve injury is extremely rare. It may be caused by radiation therapy targeting neoplasms of the cephalic region. CASE REPORT A 51-year-old man with synovial sarcoma of the left upper arm status post extensive radiation therapy in 1980 presented in late 2014 with gradual onset of speech difficulty and difficulty moving his tongue for a couple of weeks. Read More

View Article and Full-Text PDF

SAFETY AND TOXICITY OF AN ACCELERATED COARSELY FRACTIONATED RADIATION PROTOCOL FOR TREATMENT OF APPENDICULAR OSTEOSARCOMA IN 14 DOGS: 10 GY × 2 FRACTIONS.

Vet Radiol Ultrasound 2016 Sep 4;57(5):551-6. Epub 2016 Jul 4.

Department of Veterinary Clinical Sciences, Louisiana State University, Skip Bertman Dr., Baton Rouge, LA, 70803.

Coarsely fractionated radiation is commonly used as a method for pain control in dogs with appendicular osteosarcoma, however there is little published information on optimal protocols. The aim of this retrospective, descriptive study was to report safety and toxicity findings in a sample of dogs with appendicular osteosarcoma that had been treated with a radiation scheme of 10 Gy delivered over two consecutive days for a total of 20 Gy. Dogs were included in the study if they had osteosarcoma that was treated with the aforementioned protocol. Read More

View Article and Full-Text PDF
September 2016

Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features.

Arch Pathol Lab Med 2016 May;140(5):477-81

From the Departments of Anatomic Pathology (Drs Shah and Rosa) and Women's Oncology (Dr Rosa), Moffitt Cancer Center, Tampa, Florida.

Breast angiosarcoma is an unusual malignancy accounting for approximately 1% of soft tissue sarcomas. It can occur as a primary form without a known precursor or as a secondary form associated with radiotherapy. Adjuvant radiotherapy has a significant role in preventing local recurrence in women treated with conservation therapy for early stage breast carcinoma or multicentric tumors. Read More

View Article and Full-Text PDF

Photoletter to the editor: Postradiation sarcoma.

J Dermatol Case Rep 2016 Mar 31;10(1):17-8. Epub 2016 Mar 31.

Dermatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain;

Postradiation sarcomas are rare and highly malignant tumors which may appear as a consequence of radiotherapy. They may originate on bone or soft tissues.We report the case of a patient who developed a malignant fibrous histiocytoma 35 years after radiotherapy for a melanoma on her right leg. Read More

View Article and Full-Text PDF

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma.

Tex Heart Inst J 2016 Feb 1;43(1):81-3. Epub 2016 Feb 1.

Therapeutic radiotherapy rarely causes sarcoma, and this occurs years after completion of the intended treatment. In treating breast carcinoma, careful planning in the application of modern radiotherapeutic techniques usually can shield the heart and pericardium. We report a rare case of angiosarcoma of the pericardium, which presented in a 41-year-old woman as constrictive pericarditis 8 years after irradiation for cancer of the left breast. Read More

View Article and Full-Text PDF
February 2016

Postradiation angiosarcoma of bladder with extensive osseous metaplasia.

Indian J Pathol Microbiol 2016 Jan-Mar;59(1):78-80

Department of Histopathology, Apollo Hospital, Hyderabad, Telangana, India.

Angiosarcomas are rare soft tissue neoplasms accounting for <2% of all sarcomas. Rare cases have been reported in other sites like breast, spleen, liver, bone and bladder. This is a case report of an angiosarcoma of the bladder in a 65 year old lady who came with complaints of haematuria. Read More

View Article and Full-Text PDF
January 2017

Postradiation carcinosarcoma of the corpus uteri--a case report.

Eur J Gynaecol Oncol 2015 ;36(6):746-9

Introduction: Radiation therapy is a very effective treatment modality, commonly used for numerous gynecological malignancies, e.g. cervical cancer. Read More

View Article and Full-Text PDF
February 2016

Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.

Mod Pathol 2016 Jan 20;29(1):4-13. Epub 2015 Nov 20.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). Read More

View Article and Full-Text PDF
January 2016