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J Int Med Res 2019 Nov 10:300060519885269. Epub 2019 Nov 10.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Alveolar adenoma is an isolated, well-defined peripheral lung tumor that originates from type II alveolar cells. The tumor consists of a network of simple, low-cubic, epithelium-coated lacunae with varying amounts of fine and inconspicuous-to-thick spindle cells that sometimes contain mucus sample matrix. Few cases of alveolar adenoma have been reported. Read More

World J Surg Oncol 2019 May 6;17(1):79. Epub 2019 May 6.

Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, Singapore.

Background: Bipartite combined oesophageal tumours are an exceedingly rare entity and much less is known about the natural history of these tumours following curative surgery. The authors present a case of a bipartite combined oesophageal tumour comprising of sarcomatoid carcinoma and small cell carcinoma with early postoperative recurrence.

Case Presentation: A 63-year-old Chinese male with a smoking history presents with hemoptysis on a background of dysphagia and odynophagia for 1 month. Read More

Medicine (Baltimore) 2017 May;96(19):e6474

aDepartment of Cardiothoracic Surgery bDepartment of Pathology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, China.

Rationale: Primary extracranial meningiomas are rare outside the head and neck region.

Patient Concerns: A 44-year-old female patient had chest pain for more than 1 year.

Diagnoses: Preoperative chest computed tomography (CT) scan revealed a nodule in the right lower lobe, 1. Read More

Ultrasound Q 2017 Mar;33(1):55-57

*Department of Medicine, Graduate School, Kyung Hee University, and †Department of Radiology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, South Korea.

Postoperative spindle cell nodule (PSCN) is a very rare pathologic complication that can occur in association with a recent core needle biopsy, surgery, or trauma. Cases of PSCN have been reported in the lower genitourinary tract, endometrium, and thyroid but are rare in the breast. Herein, we report an ultrasound-guided biopsy-proven PSCN after ultrasound-guided vacuum-assisted excision in the breast. Read More

Urol Ann 2016 Jan-Mar;8(1):95-8

Department of Urology, Urology and Nephrology Center, Mansoura University, Egypt.

"Inflammatory pseudotumor" (IPT) has infrequently been reported in the medical journals. A retrospective analysis was conducted among more than 2,000 bladder tumor cases from January 1999 to December 2012 looking for patients with IPT in the final diagnosis. Six patients were found with median tumor size of 3. Read More

J Cutan Pathol 2016 Mar 12;43(3):252-7. Epub 2015 Oct 12.

Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Anaplastic thyroid carcinoma is a highly aggressive cancer accounting for 1-2% of thyroid malignancies. Cutaneous metastases from anaplastic thyroid carcinoma are exceedingly rare. We report a 65-year-old woman with anaplastic thyroid carcinoma (BRAF V600E mutation) who had lymph node metastases (pT4 N1b) treated by total thyroidectomy, postoperative radiotherapy, adjuvant chemotherapy (paclitaxel and pazopanib) and targeted therapy (vemurafenib). Read More

Histopathology 2015 Jul 29;67(1):20-38. Epub 2015 Jan 29.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Aims: We examined gene rearrangement and the expression of anaplastic lymphoma kinase (ALK) in urinary bladder inflammatory myofibroblastic tumour (IMT) using fluorescence in-situ hybridization (FISH) and two immunohistochemical antibodies to ALK. We also investigated whether IMT represents an immunoglobulin (Ig)G4-related disease.

Methods And Results: The performance of the Dako FLEX ALK monoclonal antibody (CD246) and the Cell Signaling Technology ALK (D5F3) XP monoclonal antibody were compared. Read More

BMC Res Notes 2014 Oct 18;7:736. Epub 2014 Oct 18.

Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Background: Primary pulmonary synovial sarcoma (PPSS) is rare. We describe a case of PPSS complicated by tibial adamantinoma that required differentiation from lung metastasis.

Case Presentation: A 39-year-old Japanese woman presented with hemoptysis, dyspnea, and a well-defined tumor measuring 3. Read More

Arch Pathol Lab Med 2014 Oct;138(10):1272-7

From the Department of Pathology, University of Michigan Medical School, Ann Arbor.

We illustrate a case of an inflammatory myofibroblastic tumor (IMT) involving the bladder in a woman with dysuria and review the literature and differential diagnosis. Inflammatory myofibroblastic tumor, also referred to as pseudosarcomatous myofibroblastic proliferation, is a rare lesion that can arise in the genitourinary system and is characterized by a fascicular arrangement of myofibroblasts with admixed inflammatory cells and slitlike vessels. Urinary bladder IMT can be a diagnostic pitfall because its histologic features (brisk mitoses, invasion into muscularis propria, and prominent nucleoli) can mimic malignancy. Read More

Oncol Lett 2014 May 28;7(5):1507-1510. Epub 2014 Feb 28.

Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.

Postoperative spindle cell nodule (PSCN) of the bladder is a rare condition. It is a type of benign lesion frequently misdiagnosed as sarcomatoid carcinoma on the basis of similar cell morphology. The present report describes a tumor affecting a 71-year-old male who had undergone three transurethral resections. Read More

Surg Neurol Int 2013 30;4:131. Epub 2013 Sep 30.

Department of Neurosurgery, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia ; Oncology Working Group, Health Research Unit, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.

Background: The incidence of extraorbital giant cell angiofibroma (GCA) is rare, with only one case located in the scalp reported in the literature. The morphological hallmark is histopathological examination showing richly vascularized pattern-less spindle cell proliferation containing pseudovascular spaces and floret-like multinucleate giant cells.

Case Description: We report a case of a 30-year-old female with a primary complaint of a painless solitary nodule arising on the left parietal region of the scalp. Read More

Pathol Int 2013 Apr;63(4):214-9

Department of Pathology, Osaka Red Cross Hospital, Osaka 543-8555, Japan.

A rare case of a mixed endometrial stromal and smooth muscle tumor arising in the uterus of a 74-year-old woman is reported. The patient underwent hysterectomy for an enlarging uterine mass, and a large intramural tumor, showing marked central hyaline necrosis with calcification, was found. The tumor consisted of an admixture of a low-grade endometrial stromal sarcoma (ESS) and a fascicular proliferation of spindle cells suggesting smooth muscle differentiation, and a characteristic 'star-burst' appearance was found. Read More

Korean J Pathol 2013 Feb 25;47(1):89-91. Epub 2013 Feb 25.

Department of Pathology, Gachon University School of Medicine, Gachon University Gil Medical Center, Incheon, Korea.

BMJ Case Rep 2012 Nov 28;2012. Epub 2012 Nov 28.

Department of Urology, Terada Clinic, Hamamatsu, Shizuoka, Japan.

A 72-year-old man with a history of prostate cancer presented 7 years postradiotherapy with a painless, egg-sized, rapidly growing nodule on the left groin at the radiation site. He underwent left high orchiectomy under a diagnosis of groin lymph node metastasis of prostate cancer. The tumour had penetrated deep into the internal inguinal ring and was resected as proximally as possible to the internal ring with a positive surgical margin. Read More

Skinmed 2011 Sep-Oct;9(5):323-5

Department of Dermatology, Venereology & Leprology, Gian Sagar Medical College & Hospital, Ram Nagar, Banur, Patiala, India.

A 39-year-old Sikh businessman of Asian origin was referred to us with complaints of a painless scrotal lesion that had enlarged over a 2-year period and was causing him discomfort. There was no history of trauma, inflammation, or infection, and no significant urologic history. Physical examination revealed a 2x2 cm skin-colored nodule of rubbery consistency on the left side of the scrotum (Figure 1), which was separate from the testicles or epididymis. Read More

Head Neck 2013 Jan 22;35(1):E13-7. Epub 2011 Nov 22.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Here, we report a case of a postoperative spindle cell nodule that mimicked recurrence with anaplastic transformation after thyroidectomy.

Methods: The course of the disease is described. The mass was studied morphologically and immunohistochemically. Read More

Kyobu Geka 2010 Jul;63(7):542-5

Department of Cardiothoracic Surgery, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

We report a case of surgical resection of a pulmonary pleomorphic carcinoma after 6 years follow-up. A 75-year-old male patient was referred to our department for an irregular shadow (32 x 17 mm) in the left upper lung lobe. Chest computed tomography (CT) conducted 6 years before showed an 8 x 5 mm nodule in the same location; after 3 years prior the nodule had a thin wall cavity, and 2 years ago a new nodule was observed within the cavity. Read More

Prog Urol 2010 Apr 21;20(4):307-10. Epub 2009 Jun 21.

Service d'anatomie et de cytologie pathologiques, hôpital Fattouma-Bourguiba, rue du 1(er) juin 1955, 5000 Monastir, Tunisie.

Myofibroblastic proliferations of the bladder in adults are unusual lesions with a benign course. These proliferations, whether spontaneous or secondary to instrumentation, have identical morphology and behaviour. Histologically, similar lesions have been reported in the literature using different names, such as inflammatory pseudotumour, pseudosarcomatous fibromyxoid tumour, nodular fasciitis, postoperative spindle cell nodule. Read More

Cornea 2009 Dec;28(10):1191-3

Pathology Department, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To report a clinicopathologic correlation of a melanoma arising from iris component of ocular melanocytosis in a child.

Methods: A 13-year-old boy developed a progressive iris nodule arising from sector iris pigmentation that was a component of congenital ocular melanocytosis involving the iris, ciliary body and choroid. The tumor was examined clinically and with ultrasound biomicroscopy (UBM), removed by peripheral iridocyclectomy, and studied histopathologically. Read More

Mod Pathol 2009 Jun;22 Suppl 2:S37-52

The James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren Building, Fruit Street, Boston, MA 2114, USA.

Tumor-like lesions of the urinary bladder are reviewed emphasizing those that are most diagnostically challenging for the pathologist and may result in serious errors in patient care if misinterpreted. The first category considered, pseudocarcinomatous proliferations, represents an area of bladder pathology only recently appreciated as being particularly treacherous because of the extent to which irregular islands of benign epithelial cells may seemingly penetrate the lamina propria and cause confusion with carcinoma. Somewhat orderly proliferations of this type have been known for years, von Brunn's nests, and are rarely a challenge for the experienced, but proliferations of an irregular nature such as may be seen most often as a result of prior radiation therapy, but sometimes due to chemotherapy or even ischemia, represent a challenging interpretation. Read More

Transplant Proc 2008 Dec;40(10):3781-3

Unit of Liver Transplantation, State University of Campinas, Campinas, Sao Paulo, Brazil.

The occurrence of de novo malignant neoplasias has been shown in postransplant patients under imunosuppression. It is the second leading cause of late death in liver transplant recipients. The greatest incidence is seen in cancers associated with chronic infection by human papilloma virus, skin cancers, oropharyngeal, and gastrointestinal (GI) malignancies. Read More

Pathol Int 2008 Dec;58(12):787-91

Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.

Despite the frequent use of fine-needle aspiration, core biopsy and surgery, postoperative spindle cell nodule (PSCN) is a rare pathological complication that may be diagnostically treacherous. Presented herein is the case of a 52-year-old woman who developed a 7 mm mammary nodular lesion 66 days after removal of an area of columnar cell hyperplasia involving cellular and architectural atypia, performed with the Mammotome Breast Biopsy System. The lesion was highly cellular and composed of intersecting fascicles of plump spindle cells with blunt-ended elongated nuclei and nucleoli easily visible. Read More

Ann Thorac Cardiovasc Surg 2007 Aug;13(4):258-61

Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Japan.

Pleural metastasis of synovial sarcoma that originally developed in the soft tissue is a very rare entity. We report here the detailed clinical features of such a case. An asymptomatic 25-year-old female, with a history of a resected synovial sarcoma in her left brachial muscle and pulmonary metastasectomy of the right lung, presented a small nodule in the periphery of the left lung on a routine chest-computed tomography. Read More

Hum Pathol 2007 Jun;38(6):807-23

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Most bladder tumors arise from the urothelium. However, there are several uncommon but significant bladder lesions that must be differentiated from urothelial carcinomas. These include both benign and malignant spindle cell lesions. Read More

Pathol Int 2007 May;57(5):276-80

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

A case of solid pancreatic hamartoma in a 58-year-old Japanese woman is presented. She had no symptoms, and a pancreatic mass was incidentally found on screening ultrasonography 4 months before admission. The patient was not alcoholic and had no history of pancreatitis. Read More

Cancer Genet Cytogenet 2007 Apr;174(2):147-50

Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Centre, Ullernchaussen 70, 0310 Oslo, Norway.

Postoperative spindle cell nodule is a localized, non-neoplastic, reparative lesion composed of closely packed proliferating spindle cells and capillaries simulating a leiomyosarcoma. The lesion typically develops at the site of a recent surgical wound several weeks to months postoperatively. Local recurrence of postoperative spindle cell nodules has not been reported, even after incomplete resection. Read More

Int J Dermatol 2007 Mar;46(3):306-8

Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.

A 54-year-old man presented with a recurrent swelling on the right occipital region of the scalp. Two months earlier, the patient had undergone an initial local excision of the lesion which had enlarged progressively over the previous 2 years on a hairless patch which had been present since birth. On examination, a 5 x 4-cm, pinkish, firm, ulcerated swelling was seen on the right occipital region with a scar running over it. Read More

Hum Pathol 2007 May 15;38(5):753-61. Epub 2007 Feb 15.

Department of Urologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Pseudosarcomatous fibromyxoid tumor (PFT), postoperative spindle cell nodule (PSN), sarcoma, and sarcomatoid carcinoma of the bladder are frequently difficult to distinguish histopathologically with significant differences in disease-related outcomes. A retrospective review of our pathology registry over the last 25 years identified 7 PFT, 10 PSN, 18 primary bladder sarcomas, and 17 sarcomatoid carcinomas. Most patients with PFT, PSN, sarcoma, and sarcomatoid carcinoma were diagnosed between the ages of 50 to 60 years with PFT and PSN most commonly detected in women. Read More

Am J Surg Pathol 2006 Dec;30(12):1502-12

Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA.

Inflammatory myofibroblastic tumor (IMT) of the urinary tract, also termed postoperative spindle cell nodule, inflammatory pseudotumor, and pseudosarcomatous fibromyxoid tumor, is rare and in the past was believed to reflect diverse entities. We reviewed a series of 46 IMTs arising in the ureter, bladder, and prostate, derived primarily from a large consultation practice. There were 30 male and 16 females aged 3 to 89 years (mean 53. Read More

Kyobu Geka 2006 Sep;59(10):959-61

Department of Thoracic Surgery, Haibara General Hospital, Makinohara, Japan.

We report a case of a previously healthy 76-year-old male with cavitating pleomorphic carcinoma of the lung. He was admitted because of an abnormal lung shadow on chest X-ray. Computed tomography (CT) showed a well-demarcated nodular shadow within thin-walled cavity in the right upper lobe. Read More

Am J Surg Pathol 2006 Jul;30(7):787-94

Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA.

Inflammatory pseudotumor or pseudosarcomatous fibromyxoid tumor and postoperative spindle cell nodule of the bladder are unusual lesions of uncertain pathogenesis which share overlapping, if not identical, histologic features. We present our experience with 42 cases, the largest series to date, to study the etio-pathogenesis, histologic features, biologic behavior and relationship to "inflammatory myofibroblastic tumor" of childhood. Patients ranged in age from 7 to 77 years (mean 47 y) and males predominated (3. Read More

Prog Urol 2005 Jun;15(3):501-4

Service de Chirurgie Infantile, Hôpital Ibn Zohr, Faculté de Médecine et de Pharmacie, Marrakech, Maroc.

Urachal sinus is a congenital anomaly secondary to insufficiently high obliteration of the urachus. It can present clinically at any age with purulent umbilical discharge. A combination of ultrasound and fistulography is essential to confirm the diagnosis. Read More

J Formos Med Assoc 2004 Jun;103(6):467-71

Department of Obstetrics and Gynecology, National Taiwan University Hospital, and College of Medicine, National Taiwan University, Taipei, Taiwan.

Angiomyofibroblastoma is a rare, recently described, distinctive benign mesenchymal tumor that occurs mainly in the vulvar region of premenopausal women. We report a case of angiomyofibroblastoma of the vulva. A 45-year-old woman reported a small, painless nodule on the left vulva which rapidly enlarged during the 6 months before she visited the hospital. Read More

Ann Diagn Pathol 2004 Apr;8(2):108-14

Department of Endocrine and Otolaryngic/Head & Neck Pathology, Armed Forces Institute of Pathology, Washington, DC, USA.

According to colleagues specializing in genitourinary pathology, the so-called postoperative spindle cell nodule of the bladder can be extremely difficult to distinguish from a spindle cell sarcomatoid carcinoma. What I have learned in 25 years about spindle cell sarcomatoid carcinoma of the larynx may, by analogy, possibly help with the genitourinary pathology problem. Read More

J Coll Physicians Surg Pak 2004 Jan;14(1):53-4

Department of Surgery, PAF Hospital, Islamabad.

The case of an old male is presented who had postoperative spindle cell nodule of urinary bladder. This benign condition mimics a sarcoma. However, the treatment modalities and the outcome are entirely different. Read More

Semin Diagn Pathol 2003 Feb;20(1):13-24

Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.

Electron microscopy in the diagnosis and academic study of myofibroblastic lesions is discussed. Myofibroblasts from granulation tissue and tumor stroma are regarded as the nearest equivalent to a "normal" myofibroblast population with which to define myofibroblastic differentiation in tumoral and pseudotumoral lesions. Histological features include a plump-spindle-cell morphology, with an ill-defined cytoplasm paler and less fibrillar than in smooth-muscle cells, and matrix collagen. Read More

J Dermatol 2002 May;29(5):310-4

Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Nodular fasciitis represents reactive myofibroblastic proliferative lesions in the subcutaneous tissue, skeletal muscles, and fascia. Uncommon clinical and pathological variants of nodular fasciitis, such as intravascular, cranial, ossifying, and proliferative fasciitis, have been described. Six cases documenting a dermal location of nodular fasciitis have been reported in the English literature. Read More

Mod Pathol 2001 Oct;14(10):1043-51

Department of Pathology and Laboratory Medicine, University of Florida and Veterans Administration Medical Center, Gainesville, Florida 32608-1197, USA.

We assessed diagnostic criteria among 38 spindle cell tumors of the urinary bladder and obtained follow-up in 36 patients. Patients comprised 28 males and 10 females aged 2.5 months to 87 years. Read More

Actas Urol Esp 2001 Feb;25(2):119-21

Servicio de Urología, Servicio de Anatomía Patológica, Hospital Virgen del Camino, Pamplona, Navarra.

Introduction: The postoperative spindle cell nodule of the urinary tract is a being proliferative lesion similar to sarcoma in the microscopic exam. We present a case of modulein renal pelvis location.

Case: A woman presenting a stag horn lithiasis in left kidney was treated by LOC and percutaneous nephroscopy. Read More

Int J Gynecol Pathol 2001 Apr;20(2):105-27

James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Department of Pathology, Fruit Street, Boston, MA 02114, USA.

The diverse mesenchymal tumors and tumor-like lesions that occur within the female genital tract include a number of lesions that have only been recently characterized and others about which there is new information. In this group are the aggressive angiomyxoma, angiomyofibroblastoma, and cellular angiofibroma. Criteria for the distinction of these lesions are reviewed, as are the pathologic features of prognostic significance in assessing smooth muscle tumors of the vulva. Read More

Am J Dermatopathol 1999 Jun;21(3):220-4

Section of Dermatopathology, Washington University Medical Center, St. Louis, Missouri 63110-1094, USA.

Spindle cell proliferations of the skin are diverse, both morphologically and mechanistically. The authors have encountered four examples of a distinctive reactive/reparative cutaneous spindle cell lesion that shows homology with ones seen in the genitourinary tract and oral cavity and that is known as "postoperative/posttraumatic spindle cell nodule" (PSCN). These occurred in the skin of the face and scalp (2 cases), arm (1 case), and vulvar skin (one case), and were clearly related historically to prior episodes of trauma. Read More

Urol Int 1996 ;56(2):119-21

Department of Urology, Leighton Hospital, Crewe, UK.

A case of postoperative spindle cell nodule of the bladder is reported. Initial pathological analysis was interpreted as leiomyosarcoma for which the patient underwent radical cystectomy, but subsequent reviews were consistent with a postoperative spindle cell nodule. Recognition of this benign, yet rare lesion is of significant importance to urologists, pathologists, and to the patient who may undergo extensive surgical procedure unnecessarily. Read More

Histopathology 1995 Jun;26(6):571-4

Department of Histopathology, South Manchester University Hospitals NHS Trust, UK.

A case of post-operative spindle cell nodule arising in the vulva of a 33-year old woman is reported and the relevant literature reviewed. This is an uncommon, benign lesion which develops soon after a surgical procedure and which is composed of mitotically active spindle cells, causing possible confusion with sarcoma. Knowledge of the clinical history and an awareness of the existence of such lesions is necessary in order to avoid misinterpretation. Read More

Aust N Z J Surg 1994 Apr;64(4):273-4

Histopathology Department, Queen Elizabeth Hospital, Woodville, South Australia.

Perce, a promising young trainee pathologist, correctly recognizes a biopsy of a benign pseudosarcoma but his diagnosis is overruled by the less well read Head of Pathology. Acting under instructions from his Chief, Perce knowingly and without protest 'signs out' this benign condition as a sarcoma. The surgeon accepts the diagnosis without question and performs radical surgery, which is complicated by postoperative haemorrhage from which the patient dies. Read More

Arch Esp Urol 1994 Jan-Feb;47(1):32-6

Servicio de Anatomía Patológica, Complejo Hospitalario de León, España.

We report on a patient who developed postoperative spindle cell nodule one month following TURP for prostatic adenocarcinoma. The foregoing was compared with other benign fibrous lesions from our records: one case of nodular fasciitis and one case of proliferative myositis. Although they were all well-defined and clinically distinct disease entities, a very close relationship concerning their origin was demonstrated histologically and immunohistochemically. Read More

Oral Surg Oral Med Oral Pathol 1992 Aug;74(2):212-5

Department of Pathology, Akron General Medical Center, Ohio.

A benign posttraumatic spindle cell proliferation arising at a site of laceration in the buccal mucosa of a 19-year old man is described. This lesion, which histologically mimicked a leiomyosarcoma, appears to represent a reactive process similar to that described as postoperative spindle cell nodules of the genitourinary tract. Reexcision of the area 1 month after biopsy revealed only scar formation and mild chronic inflammation. Read More

Diagn Cytopathol 1992 ;8(2):171-6

Department of Pathology, Mercy Hospital and Medical Center, Chicago, IL 60616.

Postoperative spindle-cell nodule of the urinary bladder (or in the absence of previous surgical procedure, inflammatory pseudotumor) is a reactive process of unknown etiology mimicking a sarcoma. Intracytoplasmic inclusion bodies were noted inside the atypical spindle cells on Diff-Quik stained smears in a recent case of this entity. Although fluorescence was noted in the inclusion bodies with monoclonal antibodies against the major outer membrane protein of the Chlamydia species, the exact nature of these inclusion bodies remains unknown. Read More

Histol Histopathol 1990 Oct;5(4):505-12

Department of Pathology, Massachusetts General Hospital, Boston 02114.

Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. On the other hand, certain other lesions such as sarcomatoid carcinomas are typically highly malignant tumours. Read More

Urology 1990 Apr;35(4):342-4

Division of Urology and Pathology, A.Z. Sint Jan, Bruges, Belgium.

We describe a new tumor of the bladder resembling sarcoma. The tumor typically develops after damage to the bladder wall, and the clinicopathologic features make it possible to recognize it as a benign lesion rather than the malignant lesions for which it can be mistaken. Read More

J Urol 1990 Apr;143(4):824-6

Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.

Postoperative spindle cell nodule of the prostate and bladder (a rare lesion often misinterpreted as sarcoma) is important to recognize. The nodule consists of a reactive proliferation of spindle cells occurring up to several months after a lower genitourinary tract procedure, such as transurethral resection or biopsy. We report on 5 patients with a spindle cell nodule after a prior operation on the prostate or bladder. Read More