9,837 results match your criteria Postmortem Radiology and Imaging


Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria.

Blood Adv 2020 Jul;4(13):2851-2864

Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling. How Plasmodium falciparum infection causes this endothelial disruption and why this occurs, particularly in the brain, is not fully understood. In this study, we have demonstrated that circulating extracellular histones, equally of host and parasite origin, are significantly elevated in CM patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2019001258DOI Listing

Cardiac Tumors.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S45-S53. Epub 2020 Apr 10.

Department of General Surgery and Medical-Surgery Specialities, University of Catania, Catania, Italy.

Cardiac tumors (CTs) are extremely rare, with an incidence of approximately 0.02% in autopsy series. Primary tumors of the heart are far less common than metastatic tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcecho.jcecho_7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293869PMC

The muscarinic M receptor modulates associative learning and memory in psychotic disorders.

Neuroimage Clin 2020 May 26;27:102278. Epub 2020 May 26.

Department of Psychiatry and Psychology, University of Maastricht, Maastricht, The Netherlands.

Background: Psychotic disorders are characterized by prominent deficits in associative learning and memory for which there are currently no effective treatments. Functional magnetic resonance imaging (fMRI) studies in psychotic disorders have identified deficits in fronto-temporal activation during associative learning and memory. The underlying pathology of these findings remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2020.102278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305431PMC

In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19.

Mod Pathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to a global public health crisis. In elderly individuals and those with comorbidities, COVID-19 is associated with high mortality, frequently caused by acute respiratory distress syndrome. We examine in situ expression of SARS-CoV-2 in airways and lung obtained at autopsy of individuals with confirmed COVID-19 infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-020-0595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304376PMC

Disturbed brain ether lipid metabolism and histology in Sjögren-Larsson syndrome.

J Inherit Metab Dis 2020 Jun 18. Epub 2020 Jun 18.

Department of Pediatric Neurology, Radboud university medical center, Amalia Children's Hospital, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The Netherlands.

Sjögren-Larsson syndrome (SLS) is a rare neurometabolic syndrome caused by deficient fatty aldehyde dehydrogenase. Patients exhibit intellectual disability, spastic paraplegia and ichthyosis. The accumulation of fatty alcohols and fatty aldehydes has been demonstrated in plasma and skin but never in brain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jimd.12275DOI Listing

Radiomic Features of Multiparametric MRI Present Stable Associations With Analogous Histological Features in Patients With Brain Cancer.

Tomography 2020 Jun;6(2):160-169

Radiology.

Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had been called into question. Here, we examine the localized relationship between MR-derived radiomic features and histology-derived "histomic" features using a data set of 16 patients with brain cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18383/j.tom.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289245PMC

Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections.

Case Rep Neurol Med 2020 10;2020:6134830. Epub 2020 Jan 10.

Department of Neurology, University of Utah, 175 N Medical Dr., Salt Lake City, UT 84132, USA.

Introduction: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/6134830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201472PMC
January 2020

Differentiation of Antemortem and Postmortem Appendicular Fractures Using Magnetic Resonance Imaging Signal Intensity Changes in Bone and Soft Tissues* †.

J Forensic Sci 2020 Jun 11. Epub 2020 Jun 11.

Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, 47907.

Intraosseous T1-weighted (T1W) and short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) signal intensity changes-so-called bone marrow edema-may be able to differentiate antemortem and postmortem fractures in human forensic imaging. The primary objective of this study was to investigate this hypothesis using an animal model. Three juvenile Landrace pigs were anesthetized and underwent MRI of both tibiae and both radii using a 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.14475DOI Listing

Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad.

Medicina (Kaunas) 2020 Jun 4;56(6). Epub 2020 Jun 4.

Department of Anesthesiology and Intensive Care Medicine, Interdisciplinary Pediatric Intensive Care Medicine, University Medical Center Rostock, 18057 Rostock, Germany.

Autoimmune pathology of acute disseminated encephalomyelitis (ADEM) is generally restricted to the brain. Our objective is to expand the phenotype of ADEM. A four-year-old girl was admitted to the pediatric emergency room of a university medical center five days after a common upper respiratory tract infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina56060277DOI Listing

Intravascular carcinomatosis of the brain: a report of two cases.

Brain Tumor Pathol 2020 Jul 1;37(3):118-125. Epub 2020 Jun 1.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

Although central nervous system (CNS) metastases are common in advanced cancer, CNS involvement solely by intravascular tumor cells, known as intravascular carcinomatosis, is extremely rare. We report two cases of brain metastasis in which tumor cells were restricted to the vascular lumina without parenchymal involvement, resulting in ischemic lesions. The first patient is a previously healthy young woman who presented with symptoms of community-acquired pneumonia and progressed to respiratory failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10014-020-00367-xDOI Listing

Spontaneous celiacomesenteric trunk dissection: Case report.

Int J Surg Case Rep 2020 21;71:128-131. Epub 2020 May 21.

Department of Radiology, Trauma and BurnCenter of Ben Arous, Tunisia.

Introduction: The celiacomesenteric trunk (CMT) is one of the most striking among the different variations of the normal vascularisation of the gastro-intestinal tract. It is often accidentally discovered during autoptical dissections, angiography or abdominal computed tomography (CT).

Case Presentation: A 27-year-old man was admitted to emergency for an acute abdominal pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.04.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256209PMC

Pulmonary postmortem computed tomography of bacterial pneumonia and pulmonary edema in patients following non-traumatic in-hospital death.

Leg Med (Tokyo) 2020 May 19;45:101716. Epub 2020 May 19.

Radiology, Graduate School of Medicine, The University of Tokyo, Japan.

In this study, we compared the postmortem computed tomography (PMCT) findings among nonpathological lungs, lungs with bacterial pneumonia, and lungs with pulmonary edema in patients following non-traumatic in-hospital death. We studied 104 consecutive adult patients (208 lungs) who died in our tertiary care hospital and underwent PMCT and pathological autopsy (both within 2.5 days after death), and were pathologically diagnosed with nonpathological lungs, bacterial pneumonia, and pulmonary edema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.legalmed.2020.101716DOI Listing
May 2020
1.441 Impact Factor

Calcifications of the Medial Choroid in the Velum Interpositum: An Unrecognized Site of Physiological Calcifications Evident on MDCT.

World Neurosurg 2020 May 10. Epub 2020 May 10.

Department of Neurosurgery, Penn State Hershey Medical Center.

Purpose: In adult patients imaged using multidetector computed tomography (CT) of the brain, we observed a linear calcification along the deep venous system on thin (<3mm) sagittal reconstructions. We found no reports of this finding in the velum interpositum (VI) in the imaging literature. In order to determine the nature of this finding we performed a focused examination of the VI on two autopsy cases and retrospectively reviewed sagittal, thin section reconstructions of CT scans of 273 consecutively imaged adult patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2020.05.042DOI Listing

Postmortem Computed Tomography: An Overview for Forensic Nurses Involved in Death Investigation.

J Forensic Nurs 2020 Apr/Jun;16(2):90-98

Faculty of Health and Life Sciences, De Montfort University.

The traditional invasive autopsy has been considered the "gold standard" for death investigation worldwide. However, this has now been challenged by a new minimally invasive approach that utilizes cross-sectional radiological imaging to investigate the death. Globally, postmortem computed tomography is the most commonly used modality and is becoming increasingly available throughout the world. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JFN.0000000000000288DOI Listing

Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study.

Neuropsychopharmacology 2020 May 13. Epub 2020 May 13.

Departments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.

Proton magnetic resonance spectroscopy (H-MRS) studies have examined glutamatergic abnormalities in schizophrenia, mostly in single voxels. Though the critical brain nodes remain unknown, schizophrenia involves networks with broad abnormalities. Hence, glutamine plus glutamate (Glx) and other metabolites were examined with whole-brain H-MRS, in early schizophrenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-020-0707-yDOI Listing

PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.

Nat Commun 2020 May 12;11(1):2360. Epub 2020 May 12.

Interdepartmental Neuroscience Program, Yale University, New Haven, CT, 06510, USA.

Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals with PTSD. [C]PBR28 Positron Emission Tomography brain imaging of the 18-kDa translocator protein (TSPO), a microglial biomarker, was conducted in 23 individuals with PTSD and 26 healthy individuals-with or without trauma exposure. Prefrontal-limbic TSPO availability in the PTSD group was negatively associated with PTSD symptom severity and was significantly lower than in controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-15930-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217830PMC

Effect of minimally invasive autopsy and ethnic background on acceptance of clinical postmortem investigation in adults.

PLoS One 2020 11;15(5):e0232944. Epub 2020 May 11.

Department of Pathology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Objectives: Autopsy rates worldwide have dropped significantly over the last five decades. Imaging based autopsies are increasingly used as alternatives to conventional autopsy (CA). The aim of this study was to investigate the effect of the introduction of minimally invasive autopsy, consisting of CT, MRI and tissue biopsies on the overall autopsy rate (of CA and minimally invasive autopsy) and the autopsy rate among different ethnicities. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232944PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213690PMC

Intrauterine versus post-mortem magnetic resonance in second trimester termination of pregnancy for central nervous system abnormalities.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 23;250:31-35. Epub 2020 Apr 23.

Department of Obstetrics and Gynecology, Institute for Maternal and Child Health IRCCS "Burlo Garofolo", Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Objective: To evaluate if limiting factors of intrauterine magnetic resonance imaging (iuMRI) performed in the early second trimester of pregnancy (19-23 weeks) affect its accuracy in comparison to post-mortem MRI (pmMRI) in fetuses that underwent termination of pregnancy (TOP) for central nervous system (CNS) defects.

Study Design: This is a secondary analysis of a 10 years prospective observational study. Cases of TOP < 23 weeks for CNS malformation that had undergone neurosonography (NSG), iuMRI, pmMRI and autopsy were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2020.04.032DOI Listing
April 2020
1.627 Impact Factor

Overview of Pathologic Findings of Vaping in the Context of an Autopsy Patient With Chronic Injury.

Arch Pathol Lab Med 2020 May 8. Epub 2020 May 8.

From the Departments of Pathology (Drs Priemer, Gravenmier, and Hooper) and Radiology (Dr Batouli), Johns Hopkins University, Baltimore, Maryland.

Context.—: Electronic cigarettes are handheld devices that heat an inner liquid containing chemicals to be aerosolized and inhaled, and have become a popular alternative to conventional cigarettes. Their use, termed , has been linked to severe injury, with 2711 cases of associated lung injury and 60 deaths reported to the Centers for Disease Control and Prevention at time of writing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5858/arpa.2019-0637-RADOI Listing

In Vivo Imaging of Gray Matter Microstructure in Major Psychiatric Disorders: Opportunities for Clinical Translation.

Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Mar 25. Epub 2020 Mar 25.

Kimel Family Translational Imaging Genetics Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Postmortem studies reveal that individuals with major neuropsychiatric disorders such as schizophrenia and autism spectrum disorder have gray matter microstructural abnormalities. These include abnormalities in neuropil organization, expression of proteins supporting neuritic and synaptic integrity, and myelination. Genetic and postmortem studies suggest that these changes may be causally linked to the pathogenesis of these disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpsc.2020.03.003DOI Listing

Postmortem Computed Tomography and Magnetic Resonance Imaging of an Abdominal Gunshot Wound.

Am J Forensic Med Pathol 2020 Jun;41(2):119-123

From the Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich.

The use of postmortem computed tomography (CT) has been described in many articles concerning gunshot injuries. Postmortem magnetic resonance imaging (MRI) for better assessment of soft tissue injuries has also been mentioned in the literature, albeit much less often. The use of postmortem MRI for abdominal gunshot wounds has not been previously presented in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAF.0000000000000547DOI Listing

The Subplate Layers: The Superficial and Deep Subplate Can be Discriminated on 3 Tesla Human Fetal Postmortem MRI.

Cereb Cortex 2020 May 7. Epub 2020 May 7.

Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.

The subplate (SP) is a transient structure of the human fetal brain that becomes the most prominent layer of the developing pallium during the late second trimester. It is important in the formation of thalamocortical and cortico-cortical connections. The SP is vulnerable in perinatal brain injury and may play a role in complex neurodevelopmental disorders, such as schizophrenia and autism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhaa099DOI Listing

Fetal postmortem imaging: an overview of current techniques and future perspectives.

Am J Obstet Gynecol 2020 May 3. Epub 2020 May 3.

Department of Obstetrics and Gynecology and, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

Fetal death because of miscarriage, unexpected in utero fetal demise, or termination of pregnancy is a traumatic event for any family. Despite advances in prenatal imaging as well as genetic diagnosis, conventional autopsy remains the gold standard since in up to 40% of cases it can provide additional information that was not available during fetal life and this by itself may change the recurrence risk and hence future counseling for parents. However, conventional autopsy is negatively impacted by procedures involving long reporting times because the fetal brain is prone to the effect of autolysis, which may result in suboptimal examinations, particularly of the central nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2020.04.034DOI Listing

Postmortem computed tomography of gas gangrene with aortic gas in a dialysis patient.

CEN Case Rep 2020 Apr 22. Epub 2020 Apr 22.

Department of Nephrology, Saiyu Soka Hospital, 1-7-22 Matsubara, Soka, Saitama, Japan.

Recently, postmortem imaging is sometimes used as an alternative to conventional autopsy. However, there are few case reports of postmortem imaging of dialysis patients. Here, we report a fatal case of gas gangrene involving a 76-year-old man who underwent dialysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13730-020-00456-yDOI Listing

Exposure to gadolinium and neurotoxicity: current status of preclinical and clinical studies.

Neuroradiology 2020 Apr 21. Epub 2020 Apr 21.

Departmental Faculty of Medicine and Surgery, Unit of Diagnostic Imaging and Interventional Radiology, Università Campus Bio-Medico di Roma, Rome, Italy.

Purpose: Gadolinium is a rare-earth lanthanide metal that is known to have a direct neurotoxic effect. The scope of the present review is to summarize the current preclinical and clinical evidence on the association between exposure to gadolinium of the central nervous system and neurotoxicity.

Methods: A literature review was performed by searching for original research papers investigating on gadolinium exposure and neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00234-020-02434-8DOI Listing

A Holistic Multi-Scale Approach to Using 3D Scanning Technology in Accident Reconstruction.

J Forensic Sci 2020 Apr 21. Epub 2020 Apr 21.

Warwick Manufacturing Group, International Manufacturing Centre, University of Warwick, Coventry, CV4 7AL, England.

Three-dimensional scanning and documentation methods are becoming increasingly employed by law enforcement personnel for crime scene and accident scene recording. Three-dimensional documentation of the victim's body in such cases is also increasingly used as the field of forensic radiology and imaging is expanding rapidly. These scanning technologies enable a more complete and detailed documentation than standard autopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1556-4029.14405DOI Listing

Nonbacterial Thrombotic Endocarditis and Widespread Skin Necrosis in Newly Diagnosed Lung Adenocarcinoma.

Case Rep Oncol 2020 Jan-Apr;13(1):239-244. Epub 2020 Mar 19.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.

Nonbacterial thrombotic endocarditis (NBTE) is a rare entity most commonly diagnosed postmortem with rates in autopsy series ranging from 0.9 to 1.6%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154248PMC

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies.

Mod Pathol 2020 06 14;33(6):1007-1014. Epub 2020 Apr 14.

Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients' ages ranged from 59 to 81, including three males and one female. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-020-0536-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156231PMC

Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in the frontal cortex of healthy controls and Alzheimer's disease patients.

Neuroimage 2020 Jul 11;215:116808. Epub 2020 Apr 11.

Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Accumulation of iron within the cortex of Alzheimer's disease (AD) patients has been reported by numerous MRI studies using iron-sensitive methods. Validation of iron-sensitive MRI is important for the interpretation of in vivo findings. In this study, the relation between the spatial iron distribution and T∗-weighted MRI in the human brain was investigated using a direct comparison of spatial maps of iron as detected by T∗-weighted MRI, iron histochemistry and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), in postmortem brain tissue of the medial frontal gyrus of three control subjects and six AD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2020.116808DOI Listing

Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity.

Schizophr Bull 2020 Apr 14. Epub 2020 Apr 14.

Department of Disaster Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Previous studies have indicated associations between several OLIG2 gene single-nucleotide polymorphisms (SNPs) and susceptibility to schizophrenia among Caucasians. Consistent with these findings, postmortem brain and diffusion tensor imaging studies have indicated that the schizophrenia-risk-associated allele (A) in the OLIG2 SNP rs1059004 predicts lower OLIG2 gene expression in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia patients and reduced white matter (WM) integrity of the corona radiata in normal brains among Caucasians. In an effort to replicate the association between this variant and WM integrity among healthy Japanese, we found that the number of A alleles was positively correlated with WM integrity in some fiber tracts, including the right posterior limb of the internal capsule, and with mean blood flow in a widespread area, including the inferior frontal operculum, orbital area, and triangular gyrus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/schbul/sbaa049DOI Listing

In situ hybridization of feline leukemia virus in a primary neural B-cell lymphoma.

J Vet Diagn Invest 2020 May 10;32(3):454-457. Epub 2020 Apr 10.

Department of Pathology, University of Veterinary Medicine, Budapest, Hungary (Szilasi, Dénes, Mándoki, Balka).

An 8-y-old castrated male, outdoor European shorthair cat was presented with a history of hindlimb weakness and paralysis. Disease progression was continuous from the onset; deep algesia disappeared at the final stage. Radiography of the vertebral column was unremarkable; along with patient history and physical examination results, magnetic resonance imaging suggested inflammatory lesions in the spinal cord, although neoplasia could not be ruled out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1040638720915449DOI Listing

Inner SPACE: 400-Micron Isotropic Resolution MRI of the Human Brain.

Front Neuroanat 2020 19;14. Epub 2020 Mar 19.

Department of Pathology, New York University, New York, NY, United States.

Objectives: Clinically relevant neuroanatomy is challenging to teach, learn and remember since many functionally important structures are visualized best using histology stains from serial 2D planar sections of the brain. In clinical patients, the locations of specific structures then must be inferred from spatial position and surface anatomy. A 3D MRI dataset of neuroanatomy has several advantages including simultaneous multi-planar visualization in the same brain, direct end-user manipulation of the data and image contrast identical to clinical MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnana.2020.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103647PMC
March 2020
3.544 Impact Factor

Substantia Nigra Volume Dissociates Bradykinesia and Rigidity from Tremor in Parkinson's Disease: A 7 Tesla Imaging Study.

J Parkinsons Dis 2020 ;10(2):591-604

Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.

Background: In postmortem analysis of late stage Parkinson's disease (PD) neuronal loss in the substantial nigra (SN) correlates with the antemortem severity of bradykinesia and rigidity, but not tremor.

Objective: To investigate the relationship between midbrain nuclei volume as an in vivo biomarker for surviving neurons in mild-to-moderate patients using 7.0 Tesla MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JPD-191890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242837PMC
January 2020

Application of Virtual Anatomy Technology in Postmortem Examination of Medical Dispute Cases.

Fa Yi Xue Za Zhi 2020 Feb;36(1):72-76

Department of Forensic Medicine, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China.

Abstract: Objective To discuss the application value of CT scanning technology in cause of death determination of medical dispute cases. Methods From July 2017 to December 2018, postmortem CT imaging data of 12 medical dispute cases were collected. CT imaging diagnosis results and anatomy findings as well as differences between antemortem and postmortem CT diagnosis were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12116/j.issn.1004-5619.2020.01.015DOI Listing
February 2020

Gut transit time, using radiological contrast imaging, to predict early signs of necrotizing enterocolitis.

Pediatr Res 2020 Apr 4. Epub 2020 Apr 4.

Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Immature gut motility in preterm neonates may be a risk factor for necrotizing enterocolitis (NEC). Using preterm pigs as a model for infants, we hypothesized that intestinal dysmotility precedes NEC development.

Methods: Eighty-five preterm pigs were fed increasing amounts of milk diets to induce NEC lesions, as detected at autopsy on day 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-020-0871-0DOI Listing

Diagnosis of pulmonary infarction in post-mortem computed tomography and post-mortem magnetic resonance imaging-a technical note.

Int J Legal Med 2020 Apr 1. Epub 2020 Apr 1.

Institute of Forensic Medicine, University of Bern, Bühlstrasse 20, 3012, Bern, Switzerland.

Pulmonary thromboembolism may be accompanied by pulmonary infarction. Even though pulmonary thromboembolism (PTE) is a frequently found cause of death at autopsy, pulmonary infarction accompanying PTE is a less common finding and may therefore easily be misinterpreted as infectious or cancerous lung disease. Appearance of pulmonary infarction in post-mortem imaging and acquisition parameters helping to identify pulmonary infarctions are not described yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00414-020-02273-5DOI Listing

In situ identification of Action 4, SECA and QD-PEP bullets from special police ammunitions by computed tomography.

Med Sci Law 2020 Mar 31:25802420911555. Epub 2020 Mar 31.

Institute of Forensic Medicine, Health Department Basel, University of Basel, Switzerland.

Introduction: Special deformation bullets were developed for police forces to achieve a defined penetration depth (avoiding over-penetration) and a controlled energy transfer (avoiding collateral damage). This article focuses on Action 4, SECA and QD-PEP bullets. These 9 mm bullets were specially designed for controlled deformation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0025802420911555DOI Listing

The added value of postmortem magnetic resonance imaging in cases of hanging compared to postmortem computed tomography and autopsy.

Forensic Sci Med Pathol 2020 Jun 27;16(2):234-242. Epub 2020 Mar 27.

Department of Forensic Medicine and Imaging, Zurich Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse, 190/52, CH-8057, Zurich, Switzerland.

The purpose of this study was to evaluate the added value of postmortem magnetic resonance imaging (MRI) compared to postmortem computed tomography (CT) and autopsy in cases of fatal hanging. In addition, the study analyzed the strengths of each examination method regarding typical injuries in these cases. We investigated a cohort of 25 decedents who underwent CT, MRI and autopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-020-00233-4DOI Listing

Application Prospects of Virtual Autopsy in Forensic Pathological Investigations on COVID-19.

Fa Yi Xue Za Zhi 2020 Apr 25;36(2):149-156. Epub 2020 Mar 25.

Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Abstract: Autopsy of patients who died of infectious diseases is of significance for public health management. Few forensic autopsies have been performed since the outbreak of the corona virus disease 2019 (COVID-19) due to some limitations, thus forensic pathological examination failed to contribute to the prevention and treatment of infectious diseases. Virtual autopsy has unique advantages in the forensic examination of patients who died of infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12116/j.issn.1004-5619.2020.02.001DOI Listing

Advanced diffusion magnetic resonance imaging in patients with Alzheimer's and Parkinson's diseases.

Neural Regen Res 2020 Sep;15(9):1590-1600

Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.276326DOI Listing
September 2020

Three-Dimensional Surface Reconstruction of the Human Cochlear Nucleus: Implications for Auditory Brain Stem Implant Design.

J Neurol Surg B Skull Base 2020 Apr 22;81(2):114-120. Epub 2019 Feb 22.

Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States.

 The auditory brain stem implant (ABI) is a neuroprosthesis placed on the surface of the cochlear nucleus (CN) to provide hearing sensations in children and adults who are not candidates for cochlear implantation. Contemporary ABI arrays are stiff and do not conform to the curved brain stem surface. Recent advancements in microfabrication techniques have enabled the development of flexible surface arrays, but these have only been applied in animal models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082162PMC

Postmortem Magnetic Resonance Imaging and Postmortem Computed Tomography in Ligature and Manual Strangulation.

Am J Forensic Med Pathol 2020 Jun;41(2):97-103

From the Department of Forensic Medicine and Imaging, University of Zurich.

Purpose: The aim of this study was to evaluate magnetic resonance imaging (MRI) findings in cases of fatal manual or ligature strangulation. Verification of strangulation by computed tomography (CT), MRI, and at autopsy as well as its detectability in each modality was assessed.

Methods: We retrospectively analyzed 6 manual and ligature strangulation cases between 2013 and 2019 who all underwent a whole-body CT, head and neck MRI, and an autopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAF.0000000000000542DOI Listing

Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas.

Cereb Cortex 2020 May;30(6):3655-3666

Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.

The human cerebral cortex is the source of many complex behaviors and is a vulnerable target of various neuropsychiatric disorders, but transcriptional profiles linked to cerebral cortical volume (CCV) differences across brain areas remain unknown. Here, we screened CCV-related genes using an across-sample spatial correlation analysis in 6 postmortem brains and then individually validated these correlations in 1091 subjects with different ages and ethnicities. We identified 62 genes whose transcriptional profiles were repeatedly associated with CCV in more than 90% of individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhz333DOI Listing
May 2020
8.665 Impact Factor

Diagnosis of drowning using postmortem computed tomography combined with endoscopic autopsy: A case report.

Medicine (Baltimore) 2020 Mar;99(11):e19182

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai.

Rationale: Postmortem forensic imaging technologies provide a noninvasive/minimally invasive approach for imaging of internal organ structures of the human body to detect injuries, diseases, and other morphologic changes. Currently, postmortem forensic imaging methods have been widely used in determination of the cause of death. However, these methods do not allow histologic examinations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000019182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220088PMC

Postmortem CT in Trauma: An Overview.

Can Assoc Radiol J 2020 Aug 16;71(3):403-414. Epub 2020 Mar 16.

Emergency and Trauma Imaging Division, Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

As forensic radiology sees an exponential gain in popularity, postmortem computed tomography (PMCT) is increasingly being used in the appropriate setting, either as preautopsy guidance or as part of complementary virtual autopsy protocol. Many articles have expounded the value it adds to forensic pathology in the general setting and the appropriate technical parameters to be used for optimum benefit. We aim to put forth a concise review on the role of PMCT specifically in trauma and the pitfalls to be aware of. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0846537120909503DOI Listing

Thyroid carcinoma with atypical metastasis to the pituitary gland and unexpected postmortal diagnosis.

Endocrinol Diabetes Metab Case Rep 2020 Mar 13;2020. Epub 2020 Mar 13.

Departments of Endocrinology, Diabetology and Internal Medicine.

Summary: Papillary thyroid gland carcinoma is the most common type of malignancy of the endocrine system. Metastases to the pituitary gland have been described as a complication of papillary thyroid cancer in few reported cases since 1965. We report the case of a 68-year-old female patient with a well-differentiated form of thyroid gland cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EDM-19-0148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077587PMC

Diagnostic accuracy of postmortem ultrasound vs 1.5T postmortem MRI for non-invasive perinatal autopsies.

Ultrasound Obstet Gynecol 2020 Mar 9. Epub 2020 Mar 9.

Department of Clinical Radiology, Great Ormond Street Hospital for Children, London, UK.

Objectives: Non-invasive perinatal autopsies using imaging techniques have high parental acceptance, but limited access to post-mortem MRI (PMMR) has lead to alternative methods such as post-mortem ultrasound (PMUS) being investigated. The aim of this study was to determine the accuracy rate of both modalities in the same patient cohort, and determine whether PMUS could provide the same information as PMMR.

Methods: In this prospective, 5 year (2014 - 2019) single centre study, we performed 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/uog.22012DOI Listing

Cardiomyopathy associated with Ceutzfeld-Jakob disease: a diagnosis of exclusion: a case report.

Eur Heart J Case Rep 2020 Feb 17;4(1):1-5. Epub 2020 Jan 17.

Department of Cardiology, Rabin Medical Center, 39 Jabotinsky, St. 49100 Petah Tikva, Israel.

Background: Creutzfeldt-Jakob disease (CJD), the most common prion disease in humans, is primarily known for its adverse neurological impact and inevitable mortality. Data regarding myocardial involvement in CJD are scarce.

Case Summary: A 54-year-old female patient, presented with progressive effort dyspnoea, was diagnosed with unexplained non-ischaemic cardiomyopathy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcr/ytz236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047068PMC
February 2020

Temporal bone histopathology: Superior semicircular canal dehiscence.

Laryngoscope Investig Otolaryngol 2020 Feb 11;5(1):117-121. Epub 2019 Dec 11.

Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and Ear Boston Massachusetts.

Objectives: To present a histopathological case of a 91-year-old woman who was diagnosed with superior semicircular canal dehiscence postmortem.

Methods: The patient was a registered donor with the National Temporal Bone Donor Program at the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry. Computed tomography imaging was performed on each temporal bone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lio2.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042660PMC
February 2020