433 results match your criteria Postinflammatory Hyperpigmentation


Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology.

J Eur Acad Dermatol Venereol 2019 Mar 14. Epub 2019 Mar 14.

National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.

Background: Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side-effects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15497
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http://dx.doi.org/10.1111/jdv.15497DOI Listing
March 2019
6 Reads

What's New in Pigmentary Disorders.

Dermatol Clin 2019 Apr 16;37(2):175-181. Epub 2019 Feb 16.

Department of Dermatology, Henry Ford Hospital System, 3031 West Grand Boulvard, Suite 800, Detroit, MI 48202, USA. Electronic address:

Pigmentary disorders are common and can be very distressing to patients. There is a need for better, standardized therapies. The authors review the most recent data for topical, systemic, light, and laser treatments for vitiligo, melasma, and postinflammatory hyperpigmentation. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.008DOI Listing
April 2019
4 Reads

Pediatric toxic epidermal necrolysis treated successfully with infliximab.

Pediatr Dermatol 2019 Mar 4. Epub 2019 Mar 4.

Departments of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Read More

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http://dx.doi.org/10.1111/pde.13778DOI Listing
March 2019
2 Reads

Insights on an in vivo model for postinflammatory hyperpigmentation.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Postinflammatory hyperpigmentation (PIH) can occur following a multitude of inflammatory skin conditions including acne vulgaris. It is more common in darker Fitzpatrick phototypes and represents a common skin complaint in dermatology offices. Despite its common occurrence, treatment options for PIH remain limited. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17746
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http://dx.doi.org/10.1111/bjd.17746DOI Listing
February 2019
9 Reads

Erythema dyschromicum perstans: A case report and systematic review of histologic presentation and treatment.

Int J Womens Dermatol 2018 Dec 27;4(4):216-222. Epub 2018 Sep 27.

Department of Dermatology, Duke University Medical Center, Durham, North Carolina.

Objective: Erythema dyschromicum perstans (EDP) can be difficult to diagnose and treat; therefore, we reviewed the literature to assess whether histology can be used to differentiate lichen planus pigmentosus (LPP) from EDP and determine which treatments are the most effective for EDP. We also present a case of a patient who was treated successfully with narrow-band ultraviolet B (NB-UVB).

Methods: A systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was conducted up to July 2017 using four databases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183003
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http://dx.doi.org/10.1016/j.ijwd.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322153PMC
December 2018
16 Reads

The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

Eur J Pain 2018 Dec 29. Epub 2018 Dec 29.

Centre for Human Drug Research, Leiden, The Netherlands.

Background: Pain models are commonly used in drug development to demonstrate analgesic activity in healthy subjects and should therefore not cause long-term adverse effects. The ultraviolet B (UVB) model is a model for inflammatory pain in which three times the minimal erythema dose (3MED) is typically applied to induce sensitization. Based on reports of long-lasting postinflammatory hyperpigmentation (PIH) associated with 3MED, it was decided to investigate the prevalence of PIH among subjects who were previously exposed to 3MED at our research centre. Read More

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http://dx.doi.org/10.1002/ejp.1353DOI Listing
December 2018

BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris.

J Clin Aesthet Dermatol 2018 Nov 1;11(11):25-35. Epub 2018 Nov 1.

Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.

Acne vulgaris is a highly prevalent and multifactorial skin disorder that can adversely impact health-related quality of life. Factors that contribute to the pathogenesis of acne include pilosebaceous proliferation of proinflammatory () bacteria, presence of circulating androgens, excess sebum production, abnormal follicular keratinization, and multiple inflammatory cascades. Oral tetracyclines-especially doxycycline and minocycline-are frequently prescribed for the treatment of moderate-to-severe acne, given their anti-inflammatory properties and their effect on reduction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303111PMC
November 2018
2 Reads

Aesthetic considerations in female skin of color: what you need to know.

Semin Cutan Med Surg 2018 Dec;37(4):210-216

Department of Dermatology, Weill Cornell Medical College, New York, New York, USA.

The world is flat when it comes to aesthetic treatments, meaning women and men from all walks of life, regardless of culture and ethnicity or even socioeconomic status, are seeking ways to improve their appearance, prevent aging, and rejuvenate their skin. Year after year, statistics show a steady increase in people of color undergoing aesthetic treatments, with neurotoxins, fillers, laser resurfacing, and body contouring being the most sought-after procedures. When treating this cohort of patients, however, dermatologists need to be sensitized to how a patient's ethnicity affects facial structure, the tissue reaction to treatments, and patient's specific expectations for recommended therapies. Read More

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https://scmsjournal.com/article/buy_now/?id=795
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http://dx.doi.org/10.12788/j.sder.2018.053DOI Listing
December 2018
25 Reads

Hyperpigmented Upper Eyelid: A Clue to the Diagnosis of Facial Lichen Planus Pigmentosus in a Patient with Frontal Fibrosing Alopecia.

Skin Appendage Disord 2018 Oct 4;4(4):335-338. Epub 2018 Apr 4.

Universidade Federal Fluminense, Niterói, Brazil.

Facial lichen planus pigmentosus (LPPig), a rare variant of classic lichen planus, was first described in patients with frontal fibrosing alopecia (FFA) by Dlova [Br J Dermatol 2013; 168: 439-442] in 2013. The diagnosis of facial LPPig is sometimes not easy, since clinical signs and histopathological features may frequently be confused with melasma or postinflammatory hyperpigmentation. We describe a case of a postmenopausal black woman diagnosed with FFA who presented with an identical brown-grayish pigmentation of the face and upper eyelids and typical dermoscopy analysis on both regions. Read More

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https://www.karger.com/Article/FullText/487338
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http://dx.doi.org/10.1159/000487338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219244PMC
October 2018
13 Reads

The Spectrum and Sequelae of Acne in Black South Africans Seen in Tertiary Institutions.

Skin Appendage Disord 2018 Oct 30;4(4):301-303. Epub 2018 May 30.

School of Public Health and Nursing, University of KwaZulu-Natal, Durban, South Africa.

Introduction: Acne is a chronic disorder of the pilosebaceous unit affecting all ethnic groups. It remains in the top 5 skin conditions seen worldwide. The paucity of data characterizing acne in South African Blacks led us to the documentation of types and sequelae of acne. Read More

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https://www.karger.com/Article/FullText/488689
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http://dx.doi.org/10.1159/000488689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219215PMC
October 2018
11 Reads

A randomized study to evaluate the efficacy and effectiveness of two sunscreen formulations on Indian skin types IV and V with pigmentation irregularities.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):160-168

L'Oréal Research and Innovation Campus, Clichy, France.

Background: Regular exposure to ultraviolet rays is high in India, where most Indians present Fitzpatrick skin phototypes IV and V.

Aims: To evaluate the efficacy and compare the effectiveness of two sunscreen products on Indian skin types IV and V with pigmentation irregularities.

Methods: A randomized, uncontrolled and investigator-blinded, single-center study enrolled adult men and women (18-45 years) with Fitzpatrick skin phototypes IV (28° < individual typological angle <10°) and V (10° < individual typological angle < -30°) with pigmentary abnormalities seen on the face in adults (actinic lentigines and postinflammatory hyperpigmentation), who did not use sunscreens. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_932_17DOI Listing
November 2018
3 Reads
1.325 Impact Factor

Managing Periocular Filler-Related Syndrome Prior to Lower Blepharoplasty.

Aesthetic Plast Surg 2019 Feb 8;43(1):115-122. Epub 2018 Oct 8.

Keck School of Medicine, University of Southern California, 9401 Wilshire Blvd, Suite 1105, Beverly Hills, CA, 90212, USA.

Background: Hyaluronic acid (HA) fillers are extensively used in periocular volume augmentation. Although they have an excellent safety profile, filler-related issues such as visibility/palpability, contour abnormalities, malar edema, and blue-gray dyschromia can occur. Recognition and management of filler-related issues are critical prior to subsequent procedures. Read More

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http://link.springer.com/10.1007/s00266-018-1250-7
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http://dx.doi.org/10.1007/s00266-018-1250-7DOI Listing
February 2019
12 Reads

Topical brimonidine-assisted laser treatment for the prevention of therapy-related erythema and hyperpigmentation.

J Cosmet Laser Ther 2018 Sep 20:1-3. Epub 2018 Sep 20.

c Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.

Postinflammatory hyperpigmentation (PIH) and erythema are the most common adverse effects associated with laser treatment, particularly in dark-skinned individuals. Several methods have been used to prevent or minimize these adverse effects; however, to date, no definitive precautions/strategies are known to prevent post-laser PIH and erythema. We investigated whether the topical application of the α-adrenergic receptor agonist brimonidine could reduce laser treatment-related complications such as erythema and PIH. Read More

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http://dx.doi.org/10.1080/14764172.2018.1516887DOI Listing
September 2018
3 Reads

Noninvasive Atrophic Acne Scar Treatment in Asians With a 755-nm Picosecond Laser Using A Diffractive Optic Lens-A Retrospective Photographic Review.

Dermatol Surg 2019 Feb;45(2):195-202

P-Skin Professional Clinic, Kaohsiung, Taiwan, China.

Background: The diffractive lens of the picosecond laser is relatively new, and there are few reports on its efficacy in treating atrophic acne scars, especially in Asian populations.

Objective: Evaluating the efficacy of diffractive lens 755-nm picosecond laser for atrophic acne scar treatment in Asians.

Patients And Methods: Forty-two patients who were treated for facial atrophic acne scars at a private dermatological clinic were enrolled in this retrospective analysis. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001669DOI Listing
February 2019
1 Read

Treating Acne in Patients With Skin of Color.

Semin Cutan Med Surg 2018 Jun;37(3S):S71-S73

Adjunct Professor Schulich School of Medicine and Dentistry Western University Windsor, Ontario, Canada.

Patients with skin of color are more likely to develop acne and postinflammatory hyperpigmentation (PIH). Many therapies for acne have demonstrated efficacy in darker skin types and in the treatment of PIH. Semin Cutan Med Surg 37(supp3):S71-S73 © 2018 published by Frontline Medical Communications. Read More

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http://dx.doi.org/10.12788/j.sder.2018.027DOI Listing
June 2018
1 Read

The role of systemic treatments for skin lightening.

J Cosmet Dermatol 2018 Dec 21;17(6):1144-1157. Epub 2018 Aug 21.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York City, New York.

Background: Pigmentation of the skin occurs as a result of increased melanin production or deposition due to various reasons including age, hormonal imbalances, endocrine disease, inflammation, and/or exposure to damaging radiation, resulting in dermatologic conditions such as lentigines, melasma, or postinflammatory hyperpigmentation. Although numerous topical therapies exist for skin lightening, they are limited by efficacy and pigmentation recurrence after treatment cessation. New research into systemic therapies for hyperpigmentation has been promising. Read More

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http://doi.wiley.com/10.1111/jocd.12747
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http://dx.doi.org/10.1111/jocd.12747DOI Listing
December 2018
22 Reads

Glucagonoma-Associated Necrolytic Migratory Erythema: The Broad Spectrum of the Clinical and Histopathological Findings and Clues to the Diagnosis.

Am J Dermatopathol 2019 Mar;41(3):e29-e32

Department of Dermatology, Venerology and Allergology, University Medical Center, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

Necrolytic migratory erythema (NEM) is associated with glucagonoma, an endocrine malignancy of the pancreas. It is a rare and a likely underrecognized paraneoplastic dermatitis. A 38-year-old woman presented to our clinic with a 3-year history of reocurring pruritic skin rashes with increasing intensity. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9829
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http://dx.doi.org/10.1097/DAD.0000000000001219DOI Listing
March 2019
10 Reads

Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients.

Case Rep Dermatol Med 2018 9;2018:9406797. Epub 2018 Jul 9.

Department of Dermatology, Jordan University Hospital, Amman, Jordan.

Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide without predominant ethnicity. Read More

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https://www.hindawi.com/journals/cridm/2018/9406797/
Publisher Site
http://dx.doi.org/10.1155/2018/9406797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076956PMC
July 2018
16 Reads

Patterns of Over-the-counter Lightening Agent Use among Patients with Hyperpigmentation Disorders: A United States-based Cohort Study.

J Clin Aesthet Dermatol 2018 Jul 1;11(7):26-30. Epub 2018 Jul 1.

Drs. Saade, Maymone, and Vashi are with the Department of Dermatology at Boston University School of Medicine in Boston, Massachusetts.

Over-the-counter (OTC) lightening agents are commonly used to treat hyperpigmentation disorders. We sought to determine the characteristics, trends, and preferences of patients with hyperpigmentation disorders seeking OTC agents in the United States. The study was a cross-sectional study of consecutive patients with a disorder of hyperpigmentation seen in a United States-based outpatient dermatology clinic. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057735PMC
July 2018
2 Reads

Characteristics and management of Asian skin.

Int J Dermatol 2019 Feb 24;58(2):131-143. Epub 2018 Jul 24.

Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.

Color differences in skin are due to the amount and distribution of epidermal melanin. The number of melanocytes is almost the same in all skin types, but higher phototypes exhibit more melanocytes, which produce more melanin and melanosomes that are individually distributed throughout the keratinocyte layers. This characteristic ensures a natural, significant photoprotection in darker skins. Read More

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http://dx.doi.org/10.1111/ijd.14153DOI Listing
February 2019
9 Reads

Chemical peels in the treatment of acne: patient selection and perspectives.

Clin Cosmet Investig Dermatol 2018 16;11:365-372. Epub 2018 Jul 16.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA,

Acne vulgaris is the most common skin disorder in adolescents and young adults. It carries a significant psychological and economic burden to patients and society. A wide range of therapeutic options are available, including topicals and systemic therapies. Read More

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http://dx.doi.org/10.2147/CCID.S137788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053170PMC
July 2018
1 Read

Brimonidine tartrate gel plus topical steroid for the prevention of laser therapy-related postinflammatory hyperpigmentation.

Dermatol Ther 2018 09 20;31(5):e12657. Epub 2018 Jul 20.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.

Brimonidine gel, originally approved for the treatment of facial rosacea, causes direct vasoconstriction and possesses extensive utilization in dermatologic fields. A Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd:YAG) laser is generally used to treat solar lentigo (SL), often leaving unwanted postinflammatory hyperpigmentation (PIH), especially in dark-skinned individuals. A 58-year-old man with Fitzpatrick skin type IV presented to remove solar lentigines from his face. Read More

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http://dx.doi.org/10.1111/dth.12657DOI Listing
September 2018
7 Reads

The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study.

J Cosmet Dermatol 2018 Oct 29;17(5):756-761. Epub 2018 Jun 29.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited. Read More

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http://dx.doi.org/10.1111/jocd.12691DOI Listing
October 2018
6 Reads

Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians.

Lasers Med Sci 2018 Dec 15;33(9):1941-1947. Epub 2018 Jun 15.

Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI road, Rajthevi, Bangkok, 10400, Thailand.

Solar lentigines are common pigmentary lesions. Q-switched lasers are effective treatment options but postinflammatory hyperpigmentation (PIH) is common in darker skin. The objective of the study is to compare the efficacy and safety in solar lentigines of Asian skin treated by Q-switched potassium titanyl phosphate (KTP) 532-nm nanosecond laser vs. Read More

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http://dx.doi.org/10.1007/s10103-018-2560-3DOI Listing
December 2018
5 Reads

A Review of the Use of Ultrasound for Skin Tightening, Body Contouring, and Cellulite Reduction in Dermatology.

Dermatol Surg 2018 07;44(7):949-963

Both authors are affiliated with the Department of Dermatology, University of California, Irvine, Irvine, California.

Background: Ultrasound (US) technology uses acoustic waves to heat tissue, resulting in thermal damage and coagulative necrosis leading to the renewal of skin elasticity, body contouring, and destruction of cellulite.

Objective: This review will discuss the use of US for skin tightening, body contouring/sculpting, and cellulite reduction.

Materials And Methods: A literature search identified studies using US for skin tightening, body contouring/sculpting, and cellulite reduction. Read More

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http://Insights.ovid.com/crossref?an=00042728-201807000-0000
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http://dx.doi.org/10.1097/DSS.0000000000001551DOI Listing
July 2018
11 Reads

Treatment of Facial Hypopigmented Scars by the Laser Hole Technique Using a Nonfractional Carbon Dioxide Laser in Asians.

Plast Reconstr Surg 2018 08;142(2):126e-132e

Seoul, Republic of Korea From the Department of Plastic Surgery, College of Medicine, Kyung Hee University.

Background: Facial hypopigmented scars are usually characterized by white color and a glossy surface. To correct the two problems simultaneously, the authors attempted to induce persistent postinflammatory hyperpigmentation for color and to build multiple pitted scars like facial skin pores for texture. This study describes a laser hole method using a traditional nonfractional carbon dioxide laser for treatment of facial hypopigmented scars and evaluates the clinical results. Read More

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http://dx.doi.org/10.1097/PRS.0000000000004553DOI Listing
August 2018
11 Reads

Resurfacing of Facial Acne Scars With a New Variable-Pulsed Er:YAG Laser in Fitzpatrick Skin Types IV and V.

J Cutan Aesthet Surg 2018 Jan-Mar;11(1):20-25

Venkat Charmalaya-Centre for Advanced Dermatology and Postgraduate Training, 3437, 1st G Cross, 7 main, Subbanna Garden, Vijay Nagar, Bangalore, India.

Introduction: The Er:YAG laser, considered to be less effective than CO laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser.

Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V.

Materials And Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars. Read More

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http://www.jcasonline.com/text.asp?2018/11/1/20/229979
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http://dx.doi.org/10.4103/JCAS.JCAS_4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921445PMC
May 2018
7 Reads

High-fluence 1064-nm Q-Switched Nd:YAG laser: Safe and effective treatment of café-au-lait macules in Asian patients.

J Cosmet Dermatol 2018 Jun 3;17(3):380-384. Epub 2018 May 3.

Choice Dermatology Clinic, Pyeongchon, Korea.

Objectives: Café-au-lait macules (CALMs) are benign cutaneous hyperpigmentary disorders. Usually, laser therapies for cosmetic concerns result in more severe side effects in the people of Asian descent than that of Caucasians. Unfortunately, there is no gold standard for the laser treatment of CALMs in skin of people of Asian descent. Read More

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http://doi.wiley.com/10.1111/jocd.12432
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http://dx.doi.org/10.1111/jocd.12432DOI Listing
June 2018
28 Reads

Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells.

Int J Mol Sci 2018 Apr 7;19(4). Epub 2018 Apr 7.

Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.

Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. Read More

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http://dx.doi.org/10.3390/ijms19041108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979541PMC
April 2018
1 Read

Assessing the safety of superficial chemical peels in darker skin: A retrospective study.

J Am Acad Dermatol 2018 Sep 5;79(3):508-513.e2. Epub 2018 Mar 5.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:

Background: Chemical peels have shown efficacy in the treatment of acne, photoaging, and pigmentary dyschromias; however, studies evaluating side effects, particularly in patients with skin of color, are limited.

Objective: We sought to determine the frequency of side effects and complications associated with superficial chemical peels in patients with skin types III-VI.

Methods: A 5-year single center retrospective analysis was performed. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.02.064DOI Listing
September 2018
19 Reads

Ablative fractional carbon dioxide laser combined with intense pulsed light for the treatment of photoaging skin in Chinese population: A split-face study.

Medicine (Baltimore) 2018 Jan;97(3):e9494

Intense pulsed light (IPL) is effective for the treatment of lentigines, telangiectasia, and generalized erythema, but is less effective in the removal of skin wrinkles. Fractional laser is effective on skin wrinkles and textural irregularities, but can induce postinflammatory hyperpigmentation (PIH), especially in Asians. This study evaluated the safety and efficacy of ablative fractional laser (AFL) in combination with IPL in the treatment of photoaging skin in Asians. Read More

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http://dx.doi.org/10.1097/MD.0000000000009494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779741PMC
January 2018
4 Reads

Topical pimecrolimus for paediatric cutaneous mastocytosis.

Clin Exp Dermatol 2018 Jul 20;43(5):559-565. Epub 2018 Feb 20.

Pediatric Dermatology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Most cases of paediatric cutaneous mastocytosis (CM) occur before the age of 2 years, and regression occurs in only 67% of children. Given the absence of any specific therapy, CM is usually treated symptomatically. A few publications have reported the beneficial effect of calcineurin inhibitors for CM. Read More

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http://dx.doi.org/10.1111/ced.13391DOI Listing
July 2018
1 Read

Intense pulsed light is effective in treating postburn hyperpigmentation and telangiectasia in Chinese patients.

J Cosmet Laser Ther 2018 Nov - Dec;20(7-8):436-441. Epub 2018 Feb 16.

a Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi'an, Shaanxi Province , China.

Intense pulsed light (IPL) has been used to treat postinflammatory hyperpigmentation and telangiectasia in Fitzpatrick type I -II skin. However, its therapeutic effects after superficial second-degree burns in Asian populations with Fitzpatrick type III-IV skin are uncertain. Thirty-five Han Chinese patients with facial or hand hyperpigmentation and telangiectasia due to second-degree fire burns received treatment with IPL. Read More

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http://dx.doi.org/10.1080/14764172.2017.1418517DOI Listing
February 2018
57 Reads

Pigmentation Disorders: Diagnosis and Management.

Am Fam Physician 2017 Dec;96(12):797-804

Norton Audobon Hospital, Louisville, KY, USA.

Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

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December 2017
36 Reads

Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects.

Authors:
Philip R Cohen

J Clin Aesthet Dermatol 2017 Oct 1;10(10):44-47. Epub 2017 Oct 1.

Dr. Cohen is from the Department of Dermatology at the University of California San Diego, La Jolla, California.

Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing and vinpocetine. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749699PMC
October 2017
10 Reads

A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules.

J Am Acad Dermatol 2018 Sep 27;79(3):479-486. Epub 2017 Dec 27.

Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: Q-switched alexandrite lasers (QSALs) have been used for the treatment of acquired bilateral nevus of Ota-like macules (ABNOMs). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL in the treatment of ABNOM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622173289
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http://dx.doi.org/10.1016/j.jaad.2017.12.053DOI Listing
September 2018
16 Reads

Compression stockings as an effective treatment for erythema nodosum: Case series.

Int J Womens Dermatol 2017 Dec 29;3(4):231-233. Epub 2017 Sep 29.

Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ.

Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. Read More

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http://dx.doi.org/10.1016/j.ijwd.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715230PMC
December 2017
2 Reads

Microneedling: a new approach for treating textural abnormalities and scars.

Semin Cutan Med Surg 2017 Dec;36(4):155-163

Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois, USA.

Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. Read More

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https://scmsjournal.com/article/buy_now/?id=727
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http://dx.doi.org/10.12788/j.sder.2017.042DOI Listing
December 2017
7 Reads

Postinflammatory Hyperpigmentation: Epidemiology, Clinical Presentation, Pathogenesis and Treatment.

Am J Clin Dermatol 2018 Aug;19(4):489-503

Mount Sinai St. Luke's and West, 1090 Amsterdam Avenue, Suite 11B, New York, NY, 10025, USA.

Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis that develops following cutaneous inflammation. Common causes of PIH include intrinsic skin conditions (e.g. Read More

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http://dx.doi.org/10.1007/s40257-017-0333-6DOI Listing
August 2018
19 Reads

Treatment of Melasma and Post-Inflammatory Hyperpigmentation by a Picosecond 755-nm Alexandrite Laser in Asian Patients.

Ann Dermatol 2017 Dec 30;29(6):779-781. Epub 2017 Oct 30.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2017.29.
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http://dx.doi.org/10.5021/ad.2017.29.6.779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705362PMC
December 2017
33 Reads

Increased Skin Irritation by Hydroquinone and Rsetinoic Acid Used in Combination.

Ann Dermatol 2017 Dec 30;29(6):715-721. Epub 2017 Oct 30.

Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.

Background: Hydroquinone (HQ) is frequently combined with retinoic acid (RA) to enhance lightening efficacy, which may also affect skin irritancy. Although skin irritation leads to postinflammatory hyperpigmentation, little research has been performed to compare skin irritancy between each component and the combination.

Objective: This study was done to examine whether HQ-RA combination increased skin irritation induced by HQ or RA alone. Read More

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http://dx.doi.org/10.5021/ad.2017.29.6.715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705352PMC
December 2017
1 Read

Novel device-based acne treatments: comparison of a 1450-nm diode laser and microneedling radiofrequency on mild-to-moderate acne vulgaris and seborrhoea in Korean patients through a 20-week prospective, randomized, split-face study.

J Eur Acad Dermatol Venereol 2018 Apr 15;32(4):639-644. Epub 2017 Dec 15.

Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Background: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects.

Objective: To compare the clinical course of acne treatment between DL and FMR. Read More

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http://doi.wiley.com/10.1111/jdv.14714
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http://dx.doi.org/10.1111/jdv.14714DOI Listing
April 2018
29 Reads

Considerations When Treating Cosmetic Concerns in Men of Color.

Dermatol Surg 2017 Nov;43 Suppl 2:S140-S150

*Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC; †Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC; ‡Department of Dermatology, Georgetown University School of Medicine, Washington, DC; §Division of Dermatology, University of California, Los Angeles, California.

Background: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population.

Objective: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. Read More

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http://Insights.ovid.com/crossref?an=00042728-201711002-0000
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http://dx.doi.org/10.1097/DSS.0000000000001376DOI Listing
November 2017
7 Reads

Psychosocial impact of acne and postinflammatory hyperpigmentation.

An Bras Dermatol 2017 Jul-Aug;92(4):505-509

Department of Psychiatry and Behavioral Sciences; University of Miami Miller School of Medicine - Miami (FL), USA.

Background:: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20175645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595597PMC
October 2017
4 Reads

The State of Ethnic Dermatology in Canada.

J Cutan Med Surg 2017 Sep/Oct;21(5):464-466

2 Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Approximately 30% of Canadians will be members of a visible minority by 2031. When dermatology became an independent medical discipline in the late 18th and early 19th centuries, most residents of Canada and the United States were of Northern European descent. Morphology and descriptions of dermatoses are based on patients with light skin. Read More

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http://dx.doi.org/10.1177/1203475417711110DOI Listing
June 2018
5 Reads

Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention.

J Am Acad Dermatol 2017 Oct;77(4):607-621

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:

Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.01.036DOI Listing
October 2017
22 Reads

Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique.

J Am Acad Dermatol 2017 Oct;77(4):591-605

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:

Postinflammatory hyperpigmentation (PIH) commonly occurs after various endogenous and exogenous stimuli, especially in dark-skinned individuals. PIH is one of the most common complications of procedures performed using laser and other light sources. The severity of PIH is determined by the inherent skin color, degree and depth of inflammation, degree of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622173012
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http://dx.doi.org/10.1016/j.jaad.2017.01.035DOI Listing
October 2017
10 Reads

Oral melanoma and other pigmentations: when to biopsy?

J Eur Acad Dermatol Venereol 2018 Feb 14;32(2):209-214. Epub 2017 Sep 14.

Dermatology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Oral pigmentations (OPs) are often neglected, although a meticulous examination of the oral cavity is important not only in the diagnosis of oral melanoma, but also for the detection of important clinical findings that may indicate the presence of a systemic disease. OPs may be classified into two major groups on the basis of their clinical appearance: focal and diffuse pigmentations, even though this distinction may not appear so limpid in some cases. The former include amalgam tattoo, melanocytic nevi, melanoacanthoma and melanosis, while the latter include physiological/racial pigmentations, smoker's melanosis, drug-induced hyperpigmentations, postinflammatory hyperpigmentations and OPs associated with systemic diseases. Read More

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http://dx.doi.org/10.1111/jdv.14574DOI Listing
February 2018
15 Reads

A pilot study of treatment of striae distensae with variable square pulse Erbium: YAG laser resurfacing.

J Cosmet Dermatol 2017 Dec 9;16(4):466-470. Epub 2017 Aug 9.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. Various laser treatments have been employed to remove the epidermis and cause dermal wound and heating with subsequent dermal collagen remodeling.

Objective: To determine the efficacy and safety of a variable square pulse Erbium: YAG (VSP Er:YAG) laser for the treatment of striae in skin phototypes III-IV. Read More

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http://dx.doi.org/10.1111/jocd.12391DOI Listing
December 2017
16 Reads

Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.

Sci Rep 2017 08 8;7(1):7532. Epub 2017 Aug 8.

Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Read More

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http://dx.doi.org/10.1038/s41598-017-07651-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548750PMC
August 2017
4 Reads