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    376 results match your criteria Postinflammatory Hyperpigmentation

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    A review of laser and light therapy in melasma.
    Int J Womens Dermatol 2017 Mar 21;3(1):11-20. Epub 2017 Mar 21.
    Department of Dermatology, Palo Alto Medical Foundation, Sunnyvale, California.
    Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Read More

    Fractional Carbon Dioxide Laser and its Combination with Subcision in Improving Atrophic Acne Scars.
    Adv Biomed Res 2017 1;6:20. Epub 2017 Mar 1.
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Acne is a very common skin disease in which scars are seen in 95% of the patients. Although numerous treatments have been recommended, researchers are still searching for a single modality to treat the complication due to its variety in shape and depth. We compared the effects of fractional carbon dioxide (CO2) laser alone and in combination with subcision in the treatment of atrophic acne scars. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Topical treatments for acne.
    Clin Dermatol 2017 Mar - Apr;35(2):173-178. Epub 2016 Oct 27.
    Andreas Sygros Hospital, 5, University of Athens, Greece, Ionos Dragoumi Street, Athens 11528, Greece.
    Topical drugs have been used successfully to treat acne for decades. This review discusses the use, efficacy, and safety of options available via prescription. Topical antibiotics, dapsone, benzyl peroxide, azelaic acid, and topical retinoids are included. Read More

    Development of Photoonycholysis with Vandetanib Therapy.
    Skin Appendage Disord 2017 Jan 3;2(3-4):146-151. Epub 2016 Nov 3.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France; Department of Medical Oncology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. Read More

    Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study.
    J Am Acad Dermatol 2017 May 16;76(5):841-846.e2. Epub 2017 Feb 16.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders.

    Objective: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. Read More

    Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study.
    Dermatol Surg 2017 Apr;43(4):566-573
    *Department of Dermatology, Maulana Azad Medical College, New Delhi, India; †Department of Dermatology, Pondicherry Institute of Medical Sciences, Puducherry, India; ‡Department of Dermatology, Medanta, the Medicity, New Delhi.
    Background: Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation.

    Objective: To evaluate the safety and efficacy of combining glycolic acid (GA) peels with a modified Kligman formula (MKF) containing hydroquinone 2%, tretinoin 0.05%, and hydrocortisone 1% for the treatment of facial PIH in Indian patients. Read More

    Evaluation of salicylic acid peeling in comparison with topical tretinoin in the treatment of postinflammatory hyperpigmentation.
    J Cosmet Dermatol 2017 Mar 15;16(1):52-60. Epub 2016 Dec 15.
    Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta, Egypt.
    Background: Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH.

    Aim Of The Work: The aim of this work was to evaluate the efficacy, tolerability, and safety of salicylic acid peeling in comparison with topical tretinoin in the treatment of PIH. Read More

    Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review.
    JAMA Dermatol 2016 Dec 14. Epub 2016 Dec 14.
    Department of Dermatology, University of California, Davis, Sacramento3Dermatology Service, Sacramento Veterans Affairs Medical Center, Mather, California4Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn.
    Importance: Lasers are gaining interest as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma given the risk for laser-induced or exacerbated PIH.

    Objective: To assess the clinical evidence for the use of lasers in the treatment of PIH.

    Evidence Review: A systematic review was performed by searching PubMed databases from January 1, 1990, through May 31, 2016. Read More

    Cosmetic approach to the Asian population.
    Semin Cutan Med Surg 2016 Dec;35(4):238-241
    Department of Dermatology, Mount Sinai Hospital, New York, New York, USA.
    The types of cosmetic procedures favored by Asian individuals are unique and tailored to their anatomical differences. Thus, a customized approach is taken for different cosmetic procedures, ranging from neurotoxins and fillers to nonablative fractional resurfacing. The purpose of this review article is to identify the different types of cosmetic procedures commonly sought by Asian individuals and to understand how these different procedures are customized toward their aesthetic preferences. Read More

    A review of melasma treatment focusing on laser and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):223-232
    Department of Dermatology, University of Texas, McGovern School of Medicine and MD Anderson Cancer Center, Houston, Texas, USA.
    Melasma is a pigmentary disorder of unclear etiology with numerous treatment options and high recurrence rates. Laser and light therapies may be utilized cautiously as second- or third-line options for recalcitrant melasma, but low-energy settings are preferred due to the risk of postinflammatory hyperpigmentation and melasma stimulation. Commonly used lasers include the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, nonablative fractionated lasers, and intense pulsed light. Read More

    What devices to use or not use in skin of color.
    Semin Cutan Med Surg 2016 Dec;35(4):218-222
    Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
    Lasers and light sources, as well as other energy devices, including radiofrequency, ultrasound, and cold-based therapies, can be used for treatment of aging, dyschromic, or texturally uneven skin. In patients with ethnic skin (ie, skin of color), energy devices are used more cautiously to avoid adverse events. The most common and concerning adverse event is postinflammatory hyperpigmentation. Read More

    Treatment of cutaneous larva migrans with a single session of carbon dioxide laser: a study of ten cases in the Philippines.
    J Cosmet Dermatol 2017 Mar 29;16(1):91-94. Epub 2016 Nov 29.
    MediSkin Dermatology Clinic, Davao Doctors Hospital, Davao City, Philippines.
    Background: Cutaneous larva migrans (CLM) has a detrimental effect on patients' emotional and physical quality of life. Due to local unavailability of gold standard oral treatments for CLM, carbon dioxide laser was attempted. We present a case series where a single session of carbon dioxide laser treatment was associated with cessation of signs and symptoms of CLM. Read More

    Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo.
    Photodermatol Photoimmunol Photomed 2017 Jan 3;33(1):49-57. Epub 2016 Nov 3.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Background: Skin hyperpigmentary disorders including postinflammatory hyperpigmentation, melasma, solar lentigines, and conditions like freckles are common. The light-emitting diodes (LEDs) are the latest category of nonthermal and noninvasive phototherapy to be considered in skin pigmentation disorder treatment.

    Purpose: The purpose of this study was to investigate the effects of 660-nm LED on inhibition of melanogenesis. Read More

    Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey.
    J Dermatolog Treat 2016 Nov 15:1-5. Epub 2016 Nov 15.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Purpose: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.

    Materials And Methods: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH. Read More

    An efficacy and safety of nanofractional radiofrequency for the treatment of striae alba.
    J Cosmet Dermatol 2017 Mar 21;16(1):84-90. Epub 2016 Oct 21.
    Skin Center, Srinakharinwirot University, Wattana, Bangkok, Thailand.
    Background: Striae distensae (SD) is a form of dermal scar. A number of treatments have been proposed, but they usually have unsatisfactory result especially in striae alba. Recently, nanofractional RF has been developed. Read More

    Two histopathological patterns of postinflammatory hyperpigmentation: epidermal and dermal.
    J Cutan Pathol 2017 Feb 1;44(2):118-124. Epub 2016 Dec 1.
    Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
    Background: Postinflammatory hyperpigmentation (PIH) commonly occurs, but the histopathological features are not well characterized.

    Methods: A total of 21 PIH patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin were performed. Read More

    Treatment of erythematotelangiectatic rosacea with the fractionation of high-fluence, long-pulsed 595-nm pulsed dye laser.
    J Cosmet Dermatol 2017 Mar 20;16(1):12-14. Epub 2016 Oct 20.
    Choice dermatology Clinic, Pyeongchon, Korea.
    Various lasers have been used for the treatment of erythematotelangiectatic rosacea (ETR) that does not respond to systemic or topical therapy. The pulsed dye lasers (PDLs) are an effective option for ETR, and the purpuragenic fluence proved to be superior until now. Given that purpura and subsequent possible postinflammatory hyperpigmentation (PIH) are occasionally unbearable in some patients, and several studies using the low nonpurpuragenic fluence were reported. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    Microneedling: A Comprehensive Review.
    Dermatol Surg 2017 Mar;43(3):321-339
    *All authors are affiliated with the Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
    Background: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. Read More

    Adjuvant alternative treatment with chemical peeling and subsequent iontophoresis for postinflammatory hyperpigmentation, erosion with inflamed red papules and non-inflamed atrophic scars in acne vulgaris.
    J Dermatol 2017 Apr 15;44(4):401-405. Epub 2016 Oct 15.
    Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan.
    The standard management of acne vulgaris in Japan includes a combination of topical treatment with benzoyl peroxide (BPO) and BPO/clindamycin (CLDM), topical adapalene and systemic antimicrobials. However, the treatment of therapy-resistant complications such as postinflammatory hyperpigmentation (PIH), erosions with inflamed red papules and atrophic scars has not been established. We performed chemical peeling with glycolic acid and iontophoresis with ascorbyl 2-phosphate 6-palmitate and DL-α-tocopherol phosphate for the treatment of PIH, erosions with inflamed red papules and non-inflamed atrophic scars in 31 patients with acne vulgaris (mild to severe severity), and evaluated the efficacy and safety of these interventions. Read More

    Skin Hyperpigmentation in Indian Population: Insights and Best Practice.
    Indian J Dermatol 2016 Sep-Oct;61(5):487-95
    Department of Dermatology, Leprology and Venereology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
    Skin pigmentation is one of the most strikingly variable phenotypes in humans, therefore making cutaneous pigmentation disorders frequent symptoms manifesting in a multitude of forms. The most common among them include lentigines, postinflammatory hyperpigmentation, dark eye circles, and melasma. Variability of skin tones throughout the world is well-documented, some skin tones being reported as more susceptible to pigmentation disorders than others, especially in Asia and India. Read More

    Dermal Remodeling of Burn Scar by Fractional CO2 Laser.
    Aesthetic Plast Surg 2016 Oct 12;40(5):761-8. Epub 2016 Aug 12.
    Department of Dermatology, Korea University College of Medicine, Inchon-ro 73(Anam-dong 5ga), Seongbuk-gu, Seoul, 136-705, Korea.
    Background: Ablative CO2 fractional lasers have recently been introduced for burn scar treatment because of pronounced clinical outcomes with fewer treatment sessions than nonablative fractional laser.

    Objective: This study was conducted to observe clinical as well as histologic changes of burn scars after treatment with CO2 fractional laser.

    Materials And Methods: Eleven patients (one female and 10 males, aged 31-59 years) with skin phototypes III to V with burn scars received 10 sessions of fractional CO2 laser treatments (UltraPulse(®) Encore; Lumenis, Santa Clara, CA, USA) over an average 5-week interval. Read More

    Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin.
    Dermatology 2016 6;232(4):425-30. Epub 2016 Aug 6.
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
    Background: Psoriatic lesions may resolve with hypo- or hyperpigmentation. The involvement of melanocytes in this dichotomous clinical outcome is not fully investigated.

    Objectives: Qualitative and quantitative assessment of melanocytes in untreated lesional and non-lesional psoriatic skin (n = 15) and healthy controls (n = 10). Read More

    Using a Low Fluence Q-Switched 532/1064-nm Nd: YAG Laser for Facial Skin Depigmentation in Asian Patients: Outcome and Complication Profile Analysis.
    Ann Plast Surg 2016 Feb;77 Suppl 1:S32-5
    From the *Department of Plastic Surgery, Chang Gung Memorial Hospital, Chiayi; †Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Tauyuan; ‡Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan; §School of Medicine, College of Medicine, China Medical University, Taichung; ∥Department of Plastic Surgery, China Medical University Hospital; ¶Aesthetic Medical Center, China Medical University Hospital, Taichung; #Department of Dermatology, Shuang Ho Hospital, New Taipei City; **School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei; ††Department of Dermatology, China Medical University Hospital, Taichung; and ‡‡Department of Dermatology, Taichung Veterans General Hospital, Chia-Yi, Taiwan.
    Background And Objectives: Low fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers are widely applied for facial depigmentation. Nonetheless, few reports analyze the general outcome, complications, of single and combined therapy of 532/1064-nm Nd:YAG lasers in Asian patients with Fitzpatrick type IV skin.

    Study Design/materials And Methods: We retrospectively reviewed all consecutive patients who completed 5 consecutive sessions at 1-month intervals of treatment with 1064-nm (spot size: 5-7 mm, 1. Read More

    Practice and Educational Gaps in Abnormal Pigmentation.
    Dermatol Clin 2016 Jul;34(3):291-301
    Department of Dermatology, Henry Ford Hospital, 3031 West Grand Boulevard, Suite 800, Detroit, MI, USA. Electronic address:
    Dyschromia refers to abnormal pigmentation and is one of the most common diagnoses in dermatology. However, there are many educational and practice gaps in this area, specifically in melasma, postinflammatory hyperpigmentation, and vitiligo. This article aims to review the gold standard of care for these conditions as well as highlight common educational and practice gaps in these areas. Read More

    The Clinical Effectiveness of Intralesional Injection of 2% Zinc Sulfate Solution in the Treatment of Common Warts.
    Scientifica (Cairo) 2016 31;2016:1082979. Epub 2016 Mar 31.
    Dermatology and Andrology Department, Dermatology Clinic, Asyut, Egypt.
    Objective. To investigate the clinical efficacy and safety of intralesional injection of 2% zinc sulfate solution in the treatment of common warts. Patients and Methods. Read More

    Comparison of Q-switched Nd: YAG laser and fractional carbon dioxide laser for the treatment of solar lentigines in Asians.
    Lasers Surg Med 2016 Apr 12;48(4):354-9. Epub 2016 Jan 12.
    Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Background/objective: Solar lentigines are benign pigmented lesions that occur mostly on sun-exposed areas. Q-switched and ablative lasers are effective for removing these lesions but the high incidence of postinflammatory hyperpigmentation raises concern in darker skin types. The objective of this study is to compare the efficacy and degree of postinflammatory hyperpigmentation with the Q-switched Nd:YAG and fractional carbon dioxide (CO2 ) laser for treatment of solar lentigines in Asians. Read More

    Periorbital Hyperpigmentation: A Comprehensive Review.
    J Clin Aesthet Dermatol 2016 Jan;9(1):49-55
    Drs. Sarkar, Ranjan, Garg V, and Bansal are from the Department of Dermatology, Maulana Azad Medical College and LokNayak Hospital, New Delhi, India. Dr. Garg S is from the Department of Dermatology, Army College of Medical Sciences, Base Hopsital, Delhi Cantt-10, India. Dr. Sonthalia is from Skinnocence Clinic, Gurgaon, Haryana, India.
    Periorbital hyperpigmentation is a commonly encountered condition. There is very little scientific data available on the clinical profile and pathogenesis of periorbital hyperpigmentation. Periorbital hyperpigmentation is caused by various exogenous and endogenous factors. Read More

    Safety of a picosecond laser with diffractive lens array (DLA) in the treatment of Fitzpatrick skin types IV to VI: A retrospective review.
    J Am Acad Dermatol 2016 May 3;74(5):931-6. Epub 2016 Mar 3.
    Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York; Laser & Skin Surgery Center of New York, New York, New York. Electronic address:
    Background: Laser therapy in patients with skin of color is associated with an increased rate of complications. The 755-nm picosecond laser with the diffractive lens array (DLA) has been used for the treatment of scars, striae, and rejuvenation. By delivering high energy to focused areas, the DLA minimizes complications. Read More

    Nonablative Fractional Laser Resurfacing for Acne Scarring in Patients With Fitzpatrick Skin Phototypes IV-VI.
    Dermatol Surg 2016 Mar;42(3):392-402
    *Skin of Color Center, Department of Dermatology, Mount Sinai St. Luke's, New York, New York; †Summit Medical Group, Berkeley Heights, New Jersey; ‡Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas; §Department of Dermatology, Loma Linda University, Loma Linda, California; ‖Department of Dermatology, Tufts School of Medicine, Boston, Massachusetts; ¶Department of Dermatology, Northwestern University, Chicago, Illinois; #Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
    Background: There is a paucity of studies investigating laser resurfacing in Fitzpatrick skin phototypes (SPT) IV to VI.

    Objective: To assess the efficacy and safety of fractional nonablative laser resurfacing in the treatment of acne scarring in patients with SPT IV to VI.

    Methods And Materials: The authors conducted a randomized, investigator-blinded and rater-blinded, split-face comparative study of adults with SPT IV to VI and facial acne scars treated with 2 different density settings and the same fluence. Read More

    Postinflammatory hyperpigmentation in patients with skin of color.
    Cutis 2016 Jan;97(1):E9-E11
    Department of Dermatology, University of Florida, Gainesville, USA.
    Postinflammatory hyperpigmentation (PIH) has posed a substantial challenge for patients with higher Fitzpatrick skin types, specifically types III to VI. Treatment modalities pose a number of limitations due to the number of treatments required, potential side effects, and overall efficacy. Fortunately, multiple therapies have been delineated that can be moderately to highly efficacious in treating PIH in patients with skin of color. Read More

    Novel Low Fluence Combination Laser Treatment of Solar Lentigines in Type III Asian Skin.
    J Cutan Aesthet Surg 2015 Oct-Dec;8(4):230-2
    Department of Surgery, Singapore General Hospital, Singapore.
    Objective: To demonstrate a novel low fluence combination laser technique [Erbium-doped yttrium aluminum garnet (Erb:YAG) and neodymium-doped yttrium aluminum garnet (Nd:YAG)] to effectively treat solar lentigines in type III Asian skin in a single session.

    Design: A prospective study.

    Setting: A Singapore-based clinic. Read More

    Treatment of Postinflammatory Pigmentation Due to Acne with Q-Switched Neodymium-Doped Yttrium Aluminum Garnet In 78 Indian Cases.
    J Cutan Aesthet Surg 2015 Oct-Dec;8(4):222-6
    Department of Dermatology and STD, INHS Ashwini, Mumbai, Maharashtra, India.
    Background: Postinflammatory hyperpigmentation (PIH) is a common sequela seen in the Indian population following affliction by acne. It is psychologically extremely disturbing for the patients and can severely affect the quality of life. Very few therapeutic modalities have proved to be really efficacious in this condition. Read More

    A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions.
    Saudi J Biol Sci 2016 Jan 9;23(1):9-14. Epub 2015 Feb 9.
    Laboratory of Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
    Postinflammatory hyperpigmentation (PIH) is an acquire hypermelanosis after cutaneous inflammation and injury. The aim of the present study was to investigate a natural ingredient with the anti-inflammatory and depigmentation activities into possible applications of postinflammatory hyperpigmentation. Methanol extracts of Lespedeza bicolor and its various fractions inhibited LPS-induced NO production in RAW 264. Read More

    Comparison of Nonablative Fractional Erbium Laser 1,340 nm and Microneedling for the Treatment of Atrophic Acne Scars: A Randomized Clinical Trial.
    Dermatol Surg 2016 Feb;42(2):232-41
    *Department of Dermatology, Hospital de Clinicas de Porto Alegre and Ambulatory of Sanitary Dermatology of Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; †Department of Dermatology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; ‡Department of Dermatology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil; §Department of Surgery, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
    Background: The efficacy and safety of nonablative fractional laser for acne scars treatment has been described in several studies. Recently, microneedling treatment has been showing promising results with lower costs, quick healing time, and low risk of postinflammatory hyperpigmentation (PIH).

    Objective: To compare the effectiveness and safety of nonablative fractional erbium laser 1,340 nm and microneedling for the treatment of facial atrophic acne scars. Read More

    Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light.
    Dermatol Surg 2016 Feb;42(2):218-24
    *Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; †Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis induced by various causes including inflammatory dermatoses, injury, or cosmetic procedures, such as lasers or chemical peels, and it tends to affect dark-skinned people with greater frequency and severity. There are a variety of treatment options for PIH, including topical agents, chemical peels, laser, and light therapy. However, the results are not up to expectation. Read More

    High versus moderate energy use of bipolar fractional radiofrequency in the treatment of acne scars: a split-face double-blinded randomized control trial pilot study.
    Lasers Med Sci 2016 Feb 28;31(2):229-34. Epub 2015 Dec 28.
    Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkoknoi, Bangkok, 10700, Thailand.
    Bipolar fractional radiofrequency (FRF) device was firstly FDA-approved for treating atrophic acne scar in 2008 through the process of dermal coagulation and minimal epidermal ablation. The average energy at 60 mJ/pin was widely used to treat atrophic acne scars. However, the higher energy was delivered, the deeper ablation and coagulation were found. Read More

    An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits.
    Br J Dermatol 2016 Apr 13;174(4):862-8. Epub 2015 Dec 13.
    Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, New Center One, 3031 West Grand Blvd, Suite 800, Detroit, MI, 48202, U.S.A.
    Background: Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH. Read More

    A clinical study on oral lichen planus with special emphasis on hyperpigmentation.
    J Pharm Bioallied Sci 2015 Aug;7(Suppl 2):S495-8
    Department of Oral Pathology, Vivekanandha Dental College for Women, Tiruchengode, Tamil Nadu, India.
    Background: Oral lichen planus (OLP) is a unique disorder affecting generally the older age group. Numerous studies have been done on various aspects of OLP such as pathogenesis, rate of malignant transformation, etc. However, very few studies are available with respect to clinical features especially association of hyperpigmentation and OLP. Read More

    A prospective, randomized, double-blind comparison of an ablative fractional 2940-nm erbium-doped yttrium aluminum garnet laser with a nonablative fractional 1550-nm erbium-doped glass laser for the treatment of photoaged Asian skin.
    J Dermatolog Treat 2015 29;26(6):551-7. Epub 2015 Sep 29.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Background: As compared with ablative fractional CO2 laser, ablative fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser is considered to be a more suitable treatment option for photoaged skin in Asians due to the lower incidence of postinflammatory hyperpigmentation.

    Objective: To compare the efficacy and safety of ablative fractional Er:YAG laser (ablative fractional resurfacing [AFR]) and nonablative fractional 1550-nm Er:glass laser (non-AFR [NAFR]) in the treatment of photoaging.

    Methods: This was a prospective, randomized, double-blinded comparative study. Read More

    [Undesirable pigmentation].
    Hautarzt 2015 Oct;66(10):757-63
    Klinik für Dermatologie und Allergologie, Hauttumorzentrum Wiesbaden, HSK, Dr. Horst Schmidt Kliniken, Helios Verbundklinik, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland.
    Background: Homogenous pigmentation can be induced by α-melanocyte-stimulating hormone (MSH) homologues. Cosmetically inacceptable pigmentation is mostly located on the face.

    Objectives: Although afamelatonide is a prescription drug for the orphan disease erthropoetic protoporphyria, structurally related α-MSH derivatives are available via the internet. Read More

    Inhibition of Angiofibromas in a Tuberous Sclerosis Patient Using Topical Timolol 0.5% Gel.
    Pediatrics 2015 Sep;136(3):e709-13
    Angiofibromas are the most recognized cutaneous manifestations of tuberous sclerosis complex. Angiofibromas can be associated with disfigurement, bleeding, pruritus, and erythema and may lead to significant psychosocial consequences for affected patients. Histopathologically, angiofibromas consist of a mixture of vascular and interstitial cells. Read More

    Retinoic acid and glycolic acid combination in the treatment of acne scars.
    Indian Dermatol Online J 2015 Mar-Apr;6(2):84-8
    Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
    Introduction: Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored. Read More

    Multiple lentigines confined to psoriatic plaques induced by biologic agents in psoriasis therapy: a case and review of the literature.
    Cutan Ocul Toxicol 2015 25;34(3):262-4. Epub 2015 Mar 25.
    Department of Dermatology and Venerology, Hacettepe University Faculty of Medicine , Ankara , Turkey.
    Multiple lentigines confined to psoriatic plaques is a rare entity, which is more frequently recognized after the use of systemic biologic agents for psoriasis therapy. Although this phenomenon was previously accepted as a postinflammatory reaction, recent observations suggest psoriasis-related cytokines and their efficient supression by biologic agents strongly associate with melanogenesis and melanocytic proliferation. Hereby, we report a patient who developed multiple lentigines arising in resolved psoriatic plaques induced by infliximab and review similar cases reported in the literature induced after biologic treatments of psoriasis. Read More

    A split-face comparison of facial hair removal with the long-pulsed alexandrite laser and intense pulsed light system.
    J Cosmet Laser Ther 2015 ;17(5):267-72
    a Department of Dermatology , College of Medicine, University of Kufa , Najaf , Iraq.
    Background: Undesirable hair growth presents a significant problem for many patients. Photoepilation has become a very popular procedure in esthetic and cosmetic practice. Among the systems used are the long-pulsed alexandrite laser (755 nm) (ALX) and intense pulsed light (IPL). Read More

    Treatment of acquired and small congenital melanocytic nevi with combined Er: YAG laser and long-pulsed alexandrite laser in Asian skin.
    Dermatol Surg 2015 Apr;41(4):473-80
    *Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; †Yonsei-Modern Skin Clinic, Seoul, Korea; ‡Human Dermatology Clinic, Korea Dermatology Research Institute, Seongnam-si, Korea.
    Background: There is no gold standard for the treatment of benign melanocytic nevi for cosmetic purposes.

    Objective: To investigate the efficacy and safety of combined treatment with the short-pulsed erbium:yttrium-aluminum-garnet (Er:YAG) and long-pulsed alexandrite laser for acquired melanocytic nevi (AMN) and small congenital melanocytic nevi (CMN).

    Methods: Fifty-eight AMN and 7 small CMN in 24 Korean patients were treated with Er:YAG laser followed by long-pulsed alexandrite laser at 1-month intervals. Read More

    Recipient site preparation for epidermal graft in stable vitiligo by a special fraise.
    An Bras Dermatol 2015 Jan-Feb;90(1):55-60
    Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background: The only approach used in the refractory lesions of stable vitiligo is the surgical supply of melanocytes. Suction Blistering Epidermal Graft is one of the most common and effective techniques. There are multiple modalities, including the motor-driven diamond fraise, for the preparation of recipient sites in suction blistering epidermal graft with different repigmentation rates and complications. Read More

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