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    402 results match your criteria Postinflammatory Hyperpigmentation

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    Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells.
    Int J Mol Sci 2018 Apr 7;19(4). Epub 2018 Apr 7.
    Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.
    Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. Read More

    Ablative fractional carbon dioxide laser combined with intense pulsed light for the treatment of photoaging skin in Chinese population: A split-face study.
    Medicine (Baltimore) 2018 Jan;97(3):e9494
    Intense pulsed light (IPL) is effective for the treatment of lentigines, telangiectasia, and generalized erythema, but is less effective in the removal of skin wrinkles. Fractional laser is effective on skin wrinkles and textural irregularities, but can induce postinflammatory hyperpigmentation (PIH), especially in Asians. This study evaluated the safety and efficacy of ablative fractional laser (AFL) in combination with IPL in the treatment of photoaging skin in Asians. Read More

    Topical pimecrolimus for paediatric cutaneous mastocytosis.
    Clin Exp Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    Pediatric Dermatology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Background: Most cases of paediatric cutaneous mastocytosis (CM) occur before the age of 2 years, and regression occurs in only 67% of children. Given the absence of any specific therapy, CM is usually treated symptomatically. A few publications have reported the beneficial effect of calcineurin inhibitors for CM. Read More

    Intense pulsed light is effective in treating postburn hyperpigmentation and telangiectasia in Chinese patients.
    J Cosmet Laser Ther 2018 Feb 16:1-6. Epub 2018 Feb 16.
    a Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi'an, Shaanxi Province , China.
    Intense pulsed light (IPL) has been used to treat postinflammatory hyperpigmentation and telangiectasia in Fitzpatrick type I -II skin. However, its therapeutic effects after superficial second-degree burns in Asian populations with Fitzpatrick type III-IV skin are uncertain. Thirty-five Han Chinese patients with facial or hand hyperpigmentation and telangiectasia due to second-degree fire burns received treatment with IPL. Read More

    Pigmentation Disorders: Diagnosis and Management.
    Am Fam Physician 2017 Dec;96(12):797-804
    Norton Audobon Hospital, Louisville, KY, USA.
    Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

    Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects.
    J Clin Aesthet Dermatol 2017 Oct 1;10(10):44-47. Epub 2017 Oct 1.
    Dr. Cohen is from the Department of Dermatology at the University of California San Diego, La Jolla, California.
    Fixed drug eruption is a cutaneous reaction to a systemic agent that typically presents as an annular or oval erythematous patch or blister and subsequently resolves with postinflammatory hyperpigmentation at the site. leaf extract and vinpocetine are nutritional supplements used to enhance memory in patients with dementia and age-related memory impairment conditions such as Alzheimer's disease. To describe a fixed drug eruption in a man who repeatedly developed pruritus and macular erythema on his distal penile shaft after ingesting a natural product containing and vinpocetine. Read More

    A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules.
    J Am Acad Dermatol 2017 Dec 27. Epub 2017 Dec 27.
    Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Background: Q-switched alexandrite lasers (QSALs) have been used for the treatment of acquired bilateral nevus of Ota-like macules (ABNOMs). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL in the treatment of ABNOM. Read More

    Compression stockings as an effective treatment for erythema nodosum: Case series.
    Int J Womens Dermatol 2017 Dec 29;3(4):231-233. Epub 2017 Sep 29.
    Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ.
    Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side effects or require a change in lifestyle. Read More

    Microneedling: a new approach for treating textural abnormalities and scars.
    Semin Cutan Med Surg 2017 Dec;36(4):155-163
    Chicago Cosmetic Surgery and Dermatology, Chicago, Illinois, USA.
    Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. Read More

    Postinflammatory Hyperpigmentation: Epidemiology, Clinical Presentation, Pathogenesis and Treatment.
    Am J Clin Dermatol 2017 Dec 8. Epub 2017 Dec 8.
    Mount Sinai St. Luke's and West, 1090 Amsterdam Avenue, Suite 11B, New York, NY, 10025, USA.
    Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis that develops following cutaneous inflammation. Common causes of PIH include intrinsic skin conditions (e.g. Read More

    Treatment of Melasma and Post-Inflammatory Hyperpigmentation by a Picosecond 755-nm Alexandrite Laser in Asian Patients.
    Ann Dermatol 2017 Dec 30;29(6):779-781. Epub 2017 Oct 30.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). Read More

    Increased Skin Irritation by Hydroquinone and Rsetinoic Acid Used in Combination.
    Ann Dermatol 2017 Dec 30;29(6):715-721. Epub 2017 Oct 30.
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
    Background: Hydroquinone (HQ) is frequently combined with retinoic acid (RA) to enhance lightening efficacy, which may also affect skin irritancy. Although skin irritation leads to postinflammatory hyperpigmentation, little research has been performed to compare skin irritancy between each component and the combination.

    Objective: This study was done to examine whether HQ-RA combination increased skin irritation induced by HQ or RA alone. Read More

    Novel device-based acne treatments: comparison of a 1450-nm diode laser and microneedling radiofrequency on mild-to-moderate acne vulgaris and seborrhoea in Korean patients through a 20-week prospective, randomized, split-face study.
    J Eur Acad Dermatol Venereol 2018 Apr 15;32(4):639-644. Epub 2017 Dec 15.
    Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
    Background: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects.

    Objective: To compare the clinical course of acne treatment between DL and FMR. Read More

    Considerations When Treating Cosmetic Concerns in Men of Color.
    Dermatol Surg 2017 Nov;43 Suppl 2:S140-S150
    *Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC; †Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC; ‡Department of Dermatology, Georgetown University School of Medicine, Washington, DC; §Division of Dermatology, University of California, Los Angeles, California.
    Background: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population.

    Objective: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. Read More

    Psychosocial impact of acne and postinflammatory hyperpigmentation.
    An Bras Dermatol 2017 Jul-Aug;92(4):505-509
    Department of Psychiatry and Behavioral Sciences; University of Miami Miller School of Medicine - Miami (FL), USA.
    Background:: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. Read More

    The State of Ethnic Dermatology in Canada.
    J Cutan Med Surg 2017 Sep/Oct;21(5):464-466
    2 Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
    Approximately 30% of Canadians will be members of a visible minority by 2031. When dermatology became an independent medical discipline in the late 18th and early 19th centuries, most residents of Canada and the United States were of Northern European descent. Morphology and descriptions of dermatoses are based on patients with light skin. Read More

    Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention.
    J Am Acad Dermatol 2017 Oct;77(4):607-621
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. Read More

    Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique.
    J Am Acad Dermatol 2017 Oct;77(4):591-605
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:
    Postinflammatory hyperpigmentation (PIH) commonly occurs after various endogenous and exogenous stimuli, especially in dark-skinned individuals. PIH is one of the most common complications of procedures performed using laser and other light sources. The severity of PIH is determined by the inherent skin color, degree and depth of inflammation, degree of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition. Read More

    A pilot study of treatment of striae distensae with variable square pulse Erbium: YAG laser resurfacing.
    J Cosmet Dermatol 2017 Dec 9;16(4):466-470. Epub 2017 Aug 9.
    Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. Various laser treatments have been employed to remove the epidermis and cause dermal wound and heating with subsequent dermal collagen remodeling.

    Objective: To determine the efficacy and safety of a variable square pulse Erbium: YAG (VSP Er:YAG) laser for the treatment of striae in skin phototypes III-IV. Read More

    Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.
    Sci Rep 2017 Aug 8;7(1):7532. Epub 2017 Aug 8.
    Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
    Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Read More

    Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser - a case report.
    Laser Ther 2017 Jun;26(2):137-144
    Department of Dermatology, Keio University School of Medicine.
    Background And Aim: Minocycline therapy for acne vulgaris is associated with the occasional induction of various types of unsightly and often persistent hyperpigmentation, which is frequently resistant to hydroquinone treatment. Pigment-specific lasers have achieved some success with multiple treatment sessions. Recently, the picosecond domain 755 nm alexandrite laser (ps-Alex) has attracted attention in tattoo removal. Read More

    A Case of Facial Partial Unilateral Lentiginosis Treated with Low-Fluence 1,064 nm Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser.
    Case Rep Dermatol 2017 May-Aug;9(2):30-34. Epub 2017 Jun 1.
    Department of Dermatology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Cheonan, Republic of Korea.
    Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Although treatment is not necessary, many patients with facial PUL seek medical help for cosmetic reasons. There is no established standard treatment for PUL. Read More

    Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris.
    J Clin Aesthet Dermatol 2017 May 1;10(5):18-23. Epub 2017 May 1.
    Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, Missouri.
    Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Read More

    Postinflammatory hyperpigmentation after human cold pain testing.
    Pain Rep 2016 Aug;1(2)
    Department of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.
    Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy adult volunteers using dry ice and a thermode. Read More

    Assessment of the Efficacy of Cryolipolysis on Saddlebags: A Prospective Study of 53 Patients.
    Plast Reconstr Surg 2017 Jul;140(1):50-57
    Créteil, France From the Department of Plastic and Cosmetic Reconstructive Surgery and Maxillofacial Surgery, Henri Mondor Hospital.
    Background: Cryolipolysis is a noninvasive subcutaneous fat removal technique. Its efficacy has been demonstrated on various fatty areas but not yet on saddlebags. The main objective of this study was to demonstrate the efficacy, patient tolerance, and safety of cryolipolysis on the saddlebags. Read More

    A review of laser and light therapy in melasma.
    Int J Womens Dermatol 2017 Mar 21;3(1):11-20. Epub 2017 Mar 21.
    Department of Dermatology, Palo Alto Medical Foundation, Sunnyvale, California.
    Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Read More

    Fractional Carbon Dioxide Laser and its Combination with Subcision in Improving Atrophic Acne Scars.
    Adv Biomed Res 2017 1;6:20. Epub 2017 Mar 1.
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Acne is a very common skin disease in which scars are seen in 95% of the patients. Although numerous treatments have been recommended, researchers are still searching for a single modality to treat the complication due to its variety in shape and depth. We compared the effects of fractional carbon dioxide (CO) laser alone and in combination with subcision in the treatment of atrophic acne scars. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigenes in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Sep;43(9):1120-1133
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigenes.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Topical treatments for acne.
    Clin Dermatol 2017 Mar - Apr;35(2):173-178. Epub 2016 Oct 27.
    Andreas Sygros Hospital, 5, University of Athens, Greece, Ionos Dragoumi Street, Athens 11528, Greece.
    Topical drugs have been used successfully to treat acne for decades. This review discusses the use, efficacy, and safety of options available via prescription. Topical antibiotics, dapsone, benzyl peroxide, azelaic acid, and topical retinoids are included. Read More

    Development of Photoonycholysis with Vandetanib Therapy.
    Skin Appendage Disord 2017 Jan 3;2(3-4):146-151. Epub 2016 Nov 3.
    Department of Oncodermatology, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France; Department of Medical Oncology and Clinical Research, Institut Claudius Regaud, Institut Universitaire du Cancer, Toulouse Oncopole, Toulouse, France.
    Vandetanib therapy is a novel once-daily oral multitargeted tyrosine kinase inhibitor, which is currently used in advanced or metastatic medullary thyroid cancer. Skin toxicities are among the most prevalent adverse events reported with this targeted therapy (e.g. Read More

    Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study.
    J Am Acad Dermatol 2017 May 16;76(5):841-846.e2. Epub 2017 Feb 16.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders.

    Objective: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. Read More

    Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study.
    Dermatol Surg 2017 Apr;43(4):566-573
    *Department of Dermatology, Maulana Azad Medical College, New Delhi, India; †Department of Dermatology, Pondicherry Institute of Medical Sciences, Puducherry, India; ‡Department of Dermatology, Medanta, the Medicity, New Delhi.
    Background: Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation.

    Objective: To evaluate the safety and efficacy of combining glycolic acid (GA) peels with a modified Kligman formula (MKF) containing hydroquinone 2%, tretinoin 0.05%, and hydrocortisone 1% for the treatment of facial PIH in Indian patients. Read More

    Evaluation of salicylic acid peeling in comparison with topical tretinoin in the treatment of postinflammatory hyperpigmentation.
    J Cosmet Dermatol 2017 Mar 15;16(1):52-60. Epub 2016 Dec 15.
    Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta, Egypt.
    Background: Postinflammatory hyperpigmentation (PIH) is an acquired hyperpigmentation that involves areas of prior cutaneous inflammation. In addition to prevention, there are a variety of medications and procedures used to treat PIH.

    Aim Of The Work: The aim of this work was to evaluate the efficacy, tolerability, and safety of salicylic acid peeling in comparison with topical tretinoin in the treatment of PIH. Read More

    Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review.
    JAMA Dermatol 2016 Dec 14. Epub 2016 Dec 14.
    Department of Dermatology, University of California, Davis, Sacramento3Dermatology Service, Sacramento Veterans Affairs Medical Center, Mather, California4Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn.
    Importance: Lasers are gaining interest as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma given the risk for laser-induced or exacerbated PIH.

    Objective: To assess the clinical evidence for the use of lasers in the treatment of PIH.

    Evidence Review: A systematic review was performed by searching PubMed databases from January 1, 1990, through May 31, 2016. Read More

    Cosmetic approach to the Asian population.
    Semin Cutan Med Surg 2016 Dec;35(4):238-241
    Department of Dermatology, Mount Sinai Hospital, New York, New York, USA.
    The types of cosmetic procedures favored by Asian individuals are unique and tailored to their anatomical differences. Thus, a customized approach is taken for different cosmetic procedures, ranging from neurotoxins and fillers to nonablative fractional resurfacing. The purpose of this review article is to identify the different types of cosmetic procedures commonly sought by Asian individuals and to understand how these different procedures are customized toward their aesthetic preferences. Read More

    A review of melasma treatment focusing on laser and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):223-232
    Department of Dermatology, University of Texas, McGovern School of Medicine and MD Anderson Cancer Center, Houston, Texas, USA.
    Melasma is a pigmentary disorder of unclear etiology with numerous treatment options and high recurrence rates. Laser and light therapies may be utilized cautiously as second- or third-line options for recalcitrant melasma, but low-energy settings are preferred due to the risk of postinflammatory hyperpigmentation and melasma stimulation. Commonly used lasers include the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, nonablative fractionated lasers, and intense pulsed light. Read More

    What devices to use or not use in skin of color.
    Semin Cutan Med Surg 2016 Dec;35(4):218-222
    Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
    Lasers and light sources, as well as other energy devices, including radiofrequency, ultrasound, and cold-based therapies, can be used for treatment of aging, dyschromic, or texturally uneven skin. In patients with ethnic skin (ie, skin of color), energy devices are used more cautiously to avoid adverse events. The most common and concerning adverse event is postinflammatory hyperpigmentation. Read More

    Treatment of cutaneous larva migrans with a single session of carbon dioxide laser: a study of ten cases in the Philippines.
    J Cosmet Dermatol 2017 Mar 29;16(1):91-94. Epub 2016 Nov 29.
    MediSkin Dermatology Clinic, Davao Doctors Hospital, Davao City, Philippines.
    Background: Cutaneous larva migrans (CLM) has a detrimental effect on patients' emotional and physical quality of life. Due to local unavailability of gold standard oral treatments for CLM, carbon dioxide laser was attempted. We present a case series where a single session of carbon dioxide laser treatment was associated with cessation of signs and symptoms of CLM. Read More

    Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo.
    Photodermatol Photoimmunol Photomed 2017 Jan 3;33(1):49-57. Epub 2016 Nov 3.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Background: Skin hyperpigmentary disorders including postinflammatory hyperpigmentation, melasma, solar lentigines, and conditions like freckles are common. The light-emitting diodes (LEDs) are the latest category of nonthermal and noninvasive phototherapy to be considered in skin pigmentation disorder treatment.

    Purpose: The purpose of this study was to investigate the effects of 660-nm LED on inhibition of melanogenesis. Read More

    Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey.
    J Dermatolog Treat 2017 Aug 15;28(5):447-451. Epub 2016 Nov 15.
    a Department of Dermatology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
    Purpose: To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.

    Materials And Methods: The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516 patients were enrolled and reviewed for clinical features and factors associated with PIH. Read More

    An efficacy and safety of nanofractional radiofrequency for the treatment of striae alba.
    J Cosmet Dermatol 2017 Mar 21;16(1):84-90. Epub 2016 Oct 21.
    Skin Center, Srinakharinwirot University, Wattana, Bangkok, Thailand.
    Background: Striae distensae (SD) is a form of dermal scar. A number of treatments have been proposed, but they usually have unsatisfactory result especially in striae alba. Recently, nanofractional RF has been developed. Read More

    Two histopathological patterns of postinflammatory hyperpigmentation: epidermal and dermal.
    J Cutan Pathol 2017 Feb 1;44(2):118-124. Epub 2016 Dec 1.
    Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
    Background: Postinflammatory hyperpigmentation (PIH) commonly occurs, but the histopathological features are not well characterized.

    Methods: A total of 21 PIH patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin were performed. Read More

    Treatment of erythematotelangiectatic rosacea with the fractionation of high-fluence, long-pulsed 595-nm pulsed dye laser.
    J Cosmet Dermatol 2017 Mar 20;16(1):12-14. Epub 2016 Oct 20.
    Choice dermatology Clinic, Pyeongchon, Korea.
    Various lasers have been used for the treatment of erythematotelangiectatic rosacea (ETR) that does not respond to systemic or topical therapy. The pulsed dye lasers (PDLs) are an effective option for ETR, and the purpuragenic fluence proved to be superior until now. Given that purpura and subsequent possible postinflammatory hyperpigmentation (PIH) are occasionally unbearable in some patients, and several studies using the low nonpurpuragenic fluence were reported. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    Microneedling: A Comprehensive Review.
    Dermatol Surg 2017 Mar;43(3):321-339
    *All authors are affiliated with the Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
    Background: Microneedling is a minimally invasive procedure that uses fine needles to puncture the epidermis. The microwounds created stimulate the release of growth factors and induce collagen production. The epidermis remains relatively intact, therefore helping to limit adverse events. Read More

    Adjuvant alternative treatment with chemical peeling and subsequent iontophoresis for postinflammatory hyperpigmentation, erosion with inflamed red papules and non-inflamed atrophic scars in acne vulgaris.
    J Dermatol 2017 Apr 15;44(4):401-405. Epub 2016 Oct 15.
    Department of Dermatology, Faculty of Medicine, Kinki University, Osaka, Japan.
    The standard management of acne vulgaris in Japan includes a combination of topical treatment with benzoyl peroxide (BPO) and BPO/clindamycin (CLDM), topical adapalene and systemic antimicrobials. However, the treatment of therapy-resistant complications such as postinflammatory hyperpigmentation (PIH), erosions with inflamed red papules and atrophic scars has not been established. We performed chemical peeling with glycolic acid and iontophoresis with ascorbyl 2-phosphate 6-palmitate and DL-α-tocopherol phosphate for the treatment of PIH, erosions with inflamed red papules and non-inflamed atrophic scars in 31 patients with acne vulgaris (mild to severe severity), and evaluated the efficacy and safety of these interventions. Read More

    Skin Hyperpigmentation in Indian Population: Insights and Best Practice.
    Indian J Dermatol 2016 Sep-Oct;61(5):487-95
    Department of Dermatology, Leprology and Venereology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
    Skin pigmentation is one of the most strikingly variable phenotypes in humans, therefore making cutaneous pigmentation disorders frequent symptoms manifesting in a multitude of forms. The most common among them include lentigines, postinflammatory hyperpigmentation, dark eye circles, and melasma. Variability of skin tones throughout the world is well-documented, some skin tones being reported as more susceptible to pigmentation disorders than others, especially in Asia and India. Read More

    Dermal Remodeling of Burn Scar by Fractional CO2 Laser.
    Aesthetic Plast Surg 2016 Oct 12;40(5):761-8. Epub 2016 Aug 12.
    Department of Dermatology, Korea University College of Medicine, Inchon-ro 73(Anam-dong 5ga), Seongbuk-gu, Seoul, 136-705, Korea.
    Background: Ablative CO2 fractional lasers have recently been introduced for burn scar treatment because of pronounced clinical outcomes with fewer treatment sessions than nonablative fractional laser.

    Objective: This study was conducted to observe clinical as well as histologic changes of burn scars after treatment with CO2 fractional laser.

    Materials And Methods: Eleven patients (one female and 10 males, aged 31-59 years) with skin phototypes III to V with burn scars received 10 sessions of fractional CO2 laser treatments (UltraPulse(®) Encore; Lumenis, Santa Clara, CA, USA) over an average 5-week interval. Read More

    Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin.
    Dermatology 2016 6;232(4):425-30. Epub 2016 Aug 6.
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
    Background: Psoriatic lesions may resolve with hypo- or hyperpigmentation. The involvement of melanocytes in this dichotomous clinical outcome is not fully investigated.

    Objectives: Qualitative and quantitative assessment of melanocytes in untreated lesional and non-lesional psoriatic skin (n = 15) and healthy controls (n = 10). Read More

    Using a Low Fluence Q-Switched 532/1064-nm Nd: YAG Laser for Facial Skin Depigmentation in Asian Patients: Outcome and Complication Profile Analysis.
    Ann Plast Surg 2016 Feb;77 Suppl 1:S32-5
    From the *Department of Plastic Surgery, Chang Gung Memorial Hospital, Chiayi; †Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Tauyuan; ‡Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan; §School of Medicine, College of Medicine, China Medical University, Taichung; ∥Department of Plastic Surgery, China Medical University Hospital; ¶Aesthetic Medical Center, China Medical University Hospital, Taichung; #Department of Dermatology, Shuang Ho Hospital, New Taipei City; **School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei; ††Department of Dermatology, China Medical University Hospital, Taichung; and ‡‡Department of Dermatology, Taichung Veterans General Hospital, Chia-Yi, Taiwan.
    Background And Objectives: Low fluence Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers are widely applied for facial depigmentation. Nonetheless, few reports analyze the general outcome, complications, of single and combined therapy of 532/1064-nm Nd:YAG lasers in Asian patients with Fitzpatrick type IV skin.

    Study Design/materials And Methods: We retrospectively reviewed all consecutive patients who completed 5 consecutive sessions at 1-month intervals of treatment with 1064-nm (spot size: 5-7 mm, 1. Read More

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