15,090 results match your criteria Postgraduate Medicine [Journal]


Real-world misuse, abuse, and dependence of abuse deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.

Postgrad Med 2019 Feb 22. Epub 2019 Feb 22.

h Pfizer Inc - Medical Affairs.

Objective: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients.

Methods: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from January 1, 2015, to June 30, 2016. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585688DOI Listing
February 2019

SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses.

Postgrad Med 2019 Feb 13. Epub 2019 Feb 13.

b Department of Internal Medicine , School of Medicine, University of Ioannina , Ioannina , Greece.

Sodium-glucose co-transporter 2 (SGLT2) inhibitors inhibit glucose re-absorption in the proximal renal tubules. Two trials have shown significant reductions of cardiovascular (CV) events with empagliflozin and canagliflozin, which could not be attributed solely to their antidiabetic effects. Aim of the review is the critical presentation of suggested mechanisms/hypotheses for the SGLT2 inhibitors-cardioprotection. Read More

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http://dx.doi.org/10.1080/00325481.2019.1581971DOI Listing
February 2019
1 Read

Management of hypoglycemia in older adults with type 2 diabetes.

Authors:
Jeffrey Freeman

Postgrad Med 2019 Feb 6. Epub 2019 Feb 6.

a Philadelphia College of Osteopathic Medicine , Philadelphia , PA , USA.

Treatment of older adults with type 2 diabetes (T2D) is complex because they represent a heterogeneous group with a broad range of comorbidities, functional abilities, socioeconomic status, and life expectancy. Older adults with T2D are at high risk of recurring hypoglycemia, a condition associated with marked morbidity and mortality, because their counter-regulatory mechanism to hypoglycemia is attenuated, and recurring hypoglycemic episodes can lead to hypoglycemia unawareness. In addition, polypharmacy, a result of multiple chronic comorbidities (including heart disease, stroke, and chronic kidney disease), can increase the risk of severe hypoglycemia, especially when patients are taking sulfonylureas or insulin. Read More

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http://dx.doi.org/10.1080/00325481.2019.1578590DOI Listing
February 2019
2 Reads

Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management.

Postgrad Med 2019 Jan 31:1-14. Epub 2019 Jan 31.

c School of Nursing , Linfield College , Portland , OR , USA.

Chronic pain is a common public health problem that has a detrimental impact on patient health, quality of life (QoL), and function, and poses a substantial socioeconomic burden. Evidence supports the redefinition of chronic pain as a distinct disease entity, not simply a symptom of injury or illness. Chronic pain conditions are characterized by three types of pain pathophysiology (i. Read More

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http://dx.doi.org/10.1080/00325481.2019.1574403DOI Listing
January 2019
11 Reads

Apremilast efficacy and safety in a psoriatic arthritis patient affected by HIV and HBV virus infections.

Postgrad Med 2019 Jan 31:1-2. Epub 2019 Jan 31.

a Department of Dermatology , University of Rome "Tor Vergata" , Rome , Italy.

Treatment of psoriasis and psoriatic arthritis in patients with concomitant chronic, severe viral infections, particularly HIV or HBV, represents a challenge, due to contraindication to conventional immunomodulating systemic drugs and biologics, including anti-TNF alpha, anti-IL12/23, and anti-IL17 agents. Recently, apremilast, a selective inhibitor of phosphodiesterase E4 has been suggested to be a safe and effective therapeutic option in HIV-infected population with psoriatic arthritis. We report the case of a patient with psoriatic arthritis and concomitant HIV and HBV infection successfully treated with apremilast. Read More

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http://dx.doi.org/10.1080/00325481.2019.1575613DOI Listing
January 2019
1 Read

Pharmacokinetic and pharmacodynamic differences of new generation, longer-acting basal insulins: potential implications for clinical practice in type 2 diabetes.

Postgrad Med 2019 Jan 29:1-12. Epub 2019 Jan 29.

e Department of Medicine , Perugia University Medical School, Hospital Santa Maria della Misericordia , Perugia , Italy.

The treatment of type 2 diabetes (T2D) is often complicated by factors such as patient co-morbidities, complex drug-drug interactions, and management of adverse events. In addition, some of these factors are highly dependent on the nature of the treatment regimen and the molecular and physical properties of the drugs being used to treat patients with this disease. This calls for a better understanding of how the properties of individual drugs affect the overall outcome for patients with diabetes. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568136DOI Listing
January 2019

A randomized, double-blind, 3-way crossover, analog classroom study of SHP465 mixed amphetamine salts extended-release in adolescents with ADHD.

Postgrad Med 2019 Jan 25:1-13. Epub 2019 Jan 25.

f Global Medical Affairs , a member of the Takeda group of companies, Lexington , MA , USA.

Objectives: To evaluate the duration of efficacy, safety, and tolerability of SHP465 mixed amphetamine salts (MAS) extended-release versus placebo and immediate-release MAS (MAS IR) in adolescents with attention-deficit/hyperactivity disorder (ADHD).

Methods: This phase 2, randomized, 3-period, 3-treatment crossover study compared SHP465 MAS (25/50 mg) with placebo and MAS IR (12.5 mg) in 13-17-year-old adolescents with ADHD having ADHD Rating Scale, Version IV (ADHD-RS-IV) total scores ≥24. Read More

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http://dx.doi.org/10.1080/00325481.2019.1574402DOI Listing
January 2019
5 Reads

A proposed anti-maladaptive aggression agent classification: improving our approach to treating impulsive aggression.

Postgrad Med 2019 Jan 24:1-9. Epub 2019 Jan 24.

f Psychiatry and Behavioral Sciences , Johns Hopkins University , Baltimore , MD , USA.

Proper drug categorization enables clinicians to readily identify the agents most appropriate for patients in need. Currently, patients with maladaptive aggression do not all always fall into a single existing diagnostic or treatment category. Such is the case for those with impulsive aggression (IA). Read More

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http://dx.doi.org/10.1080/00325481.2019.1574401DOI Listing
January 2019
1 Read

Early and late relapses of cutaneous melanoma patients.

Postgrad Med 2019 Jan 15:1-5. Epub 2019 Jan 15.

a Department of Medical Oncology, Institute of Oncology , University of Istanbul , Istanbul , Turkey.

Objectives: Recurrence may most likely develop during the course of the disease in patients presented with early stage melanoma at initial diagnosis. The specific risk factors for early and late recurrences following definitive surgical excision have yet to be determined. The aim of this study was to analyze the early and late relapses in stage I-III cutaneous melanoma patients. Read More

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http://dx.doi.org/10.1080/00325481.2019.1569354DOI Listing
January 2019
1 Read

High burden and low awareness of toxoplasmosis in the United States.

Postgrad Med 2019 Jan 14:1-6. Epub 2019 Jan 14.

b Unit of PharmacoEpidemiology & PharmacoEconomics, Department of Pharmacy , University of Groningen , Groningen , The Netherlands.

Toxoplasmosis, a disease with diverse clinical manifestations, caused by infection with the Apicomplexan parasite, Toxoplasma gondii (T. gondii), is a major source of morbidity and mortality in the United States. Although toxoplasmosis prevalence and mortality have declined over the past two decades, the CDC considers this disease a neglected parasitic infection requiring public health action. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1568792DOI Listing
January 2019
2 Reads

Impact of treatment modality on clinical outcome in metastatic colorectal cancer patients stratified by metastatic sites.

Postgrad Med 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Institute of Medicine , Chung Shan Medical University , Taichung , Taiwan.

Objectives: To investigate the impact of location of metastases, and therapeutic modality on clinical outcomes in patients with metastatic colorectal cancer (CRC).

Methods: Data for metastatic CRC patients were sourced from the Surveillance, Epidemiology, and End Results (SEER) database (SEER ID: 15309-Nov2017). Patients were classified as follows: Group 1 patients had only liver metastasis; Group 2 patients had liver and lung metastasis; Group 3 patients had more than two metastasis sites. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568016DOI Listing
January 2019
1 Read

The single use of body mass index for the obesity paradox is misleading and should be used in conjunction with other obesity indices.

Postgrad Med 2019 Feb 6:1-7. Epub 2019 Feb 6.

b Department of Cardiology , INTEGRIS Baptist Medical Center , Oklahoma City , OK , USA.

Overweight and obesity in children and adults have significantly risen in the US and worldwide due to biological, environmental, and cultural drivers and account for about 2.1 billion people. In addition, obesity, even metabolically healthy, is a major risk factor for the metabolic syndrome, diabetes mellitus, dyslipidemia, and hypertension, all significant causes of cardiovascular disease (CVD), coronary heart disease (CHD) heart failure (HF) and stroke. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568019DOI Listing
February 2019
6 Reads

Multifocal gastrointestinal varices: a rare manifestation of immunoglobulin G4-related disease.

Postgrad Med 2019 Jan 11:1-6. Epub 2019 Jan 11.

a Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine , National Cheng Kung University , Tainan , Taiwan.

Multifocal gastrointestinal varices are uncommon and often associated with liver cirrhosis. They consist of varices at the gastroesophageal region and the other sites (i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1568018DOI Listing
January 2019
6 Reads

Cardio-oncology: in search of the right balance.

Postgrad Med 2019 Jan 11:1-3. Epub 2019 Jan 11.

a Cardiovascular Medicine Division , University of Puerto Rico School of Medicine , San Juan , Puerto Rico.

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http://dx.doi.org/10.1080/00325481.2019.1568020DOI Listing
January 2019
1 Read

Treating patients with pain: how to make it less painful.

Postgrad Med 2019 01 9;131(1):6-7. Epub 2019 Jan 9.

a VA Connecticut Healthcare System , Yale University School of Medicine , West Haven , CT , USA.

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http://dx.doi.org/10.1080/00325481.2019.1563370DOI Listing
January 2019
1 Read

One-stage posterior approach for treating multilevel noncontiguous thoracic and lumbar spinal tuberculosis.

Postgrad Med 2019 Jan 26;131(1):73-77. Epub 2018 Dec 26.

b Department of Orthopaedic , Third Affiliated Hospital of Southern Medical University , Guangzhou , PR China.

Objectives: Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumentation, is effective for treating MNST.

Methods: Thirteen patients, with an average age of 40. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552824DOI Listing
January 2019
2 Reads
1.537 Impact Factor

Babesiosis as a cause of acute respiratory distress syndrome: a series of eight cases.

Postgrad Med 2018 Dec 26:1-6. Epub 2018 Dec 26.

a Division of Pulmonary, Critical Care, and Sleep Medicine , Westchester Medical Center , Valhalla , NY , USA.

Objectives: The characteristics of patients with Acute Respiratory Distress Syndrome (ARDS) as a complication of Babesia microti infection have not been systematically described.

Methods: Adult patients admitted to the medical intensive care unit (MICU) of a tertiary care hospital in the Lower Hudson Valley of New York from 1/1/2008 to 8/1/2016 were evaluated for ARDS complicating babesiosis.

Results: Of 22 patients with babesiosis in the MICU, eight (36. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1558910DOI Listing
December 2018
12 Reads

Symptomatic treatment of dengue: Should the NSAID contraindication be reconsidered?

Postgrad Med 2018 Dec 21. Epub 2018 Dec 21.

b Pfizer Consumer Healthcare , Sao Paulo , Brazil.

Consensus guidelines for treatment of dengue fever from the World Health Organization and US Centers for Disease Control recommend acetaminophen to manage pain and fever but contraindicate nonsteroidal anti-inflammatory agents (NSAIDs) because of potentially increased bleeding risk, with thrombocytopenia as a complication. Neither acetaminophen nor ibuprofen (the NSAID with lowest bleeding risk) have been evaluated for dengue treatment in randomized, controlled clinical trials. Epidemiologic and cohort studies and case series describing NSAID use in dengue generally point to minimal or no significant increase in bleeding risk, except for aspirin. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1561916DOI Listing
December 2018
7 Reads

Circulating levels of prolactin are elevated in patients with rheumatoid arthritis: a meta-analysis.

Postgrad Med 2018 Dec 20:1-7. Epub 2018 Dec 20.

a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , Anhui , China.

Background: Prolactin (PRL), an inflammatory hormone with cytokine properties, has long been proposed to play a crucial role in the pathogenesis of autoimmune disorders, including rheumatoid arthritis (RA). However, the circulating levels of PRL in RA were discordant among published studies.

Methods: PubMed, Embase, and The Cochrane Library database were systematically searched from inception up to 30 June 2018. Read More

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http://dx.doi.org/10.1080/00325481.2019.1559430DOI Listing
December 2018
1 Read

Early age at menarche is associated with insulin resistance: a systemic review and meta-analysis.

Postgrad Med 2018 Dec 18. Epub 2018 Dec 18.

a Department of Cardiology, West China Hospital , Sichuan University , Chengdu 610041 , China.

Objectives We aimed to conduct a systemic review and meta-analysis of the relevant studies to further investigate the association between age at menarche and insulin resistance. Methods PubMed, EMBASE and Web of Science (SCI) databases were systemically searched until December, 2017. Observational studies comparing the incidences of insulin resistance in patients with early, average and late menarchal ages were identified. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1559429DOI Listing
December 2018
5 Reads

Clinical analysis of false-negative fine needle aspiration cytology of head and neck cancers.

Postgrad Med 2018 Dec 17:1-5. Epub 2018 Dec 17.

a Department of Otorhinolaryngology/Head & Neck Surgery , Hamamatsu University School of Medicine , Hamamatsu , Japan.

Background: Fine-needle aspiration (FNA) cytology is frequently used for initial and/or preoperative diagnosis of tumors in the head and neck region. However, false-negative results can lead to misdiagnosis. The aim of this study was to investigate the diagnostic results of FNA in the head and neck region and the reasons for false-negative cases. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1559431DOI Listing
December 2018
8 Reads

MEFV gene variants in children with Henoch-Schönlein purpura and association with clinical manifestations: a single-center Mediterranean experience.

Postgrad Med 2019 Jan 12;131(1):68-72. Epub 2018 Dec 12.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain, and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without Familial Mediterranean Fever (FMF) symptoms and followed for at least 6 months. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552479DOI Listing
January 2019
8 Reads

Clinical workup of fatty liver for the primary care provider.

Postgrad Med 2019 Jan 29;131(1):19-30. Epub 2018 Nov 29.

d Department of Gastroenterology , University of Colorado Denver , Aurora , CO , USA.

Nonalcoholic fatty liver disease (NAFLD) is quickly emerging as a global epidemic in parallel with the rise in obesity and the Metabolic Syndrome. NAFLD, once seen simply as a passive consequence of the Metabolic Syndrome (MetS), has been found to interact with other features of MetS to exacerbate insulin resistance, diabetes, and cardiovascular disease. NAFLD is also becoming the top indication for liver transplant and an important risk factor for hepatocellular carcinoma. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546532DOI Listing
January 2019
16 Reads

Efficacy and renal outcomes of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease.

Postgrad Med 2019 Jan 30;131(1):31-42. Epub 2018 Nov 30.

d Chapman University , Orange , CA , USA.

Objective: To review glucose-lowering efficacy and changes in renal function associated with sodium-glucose co-transporter 2 (SGLT2) inhibitors among patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).

Data Sources: A literature search of MEDLINE and Cochrane databases was performed from 2000 to August 2018 using search terms: SGLT2 inhibitors, sodium glucose co-transporter 2, canagliflozin, empagliflozin, dapagliflozin, ertugliflozin, and chronic kidney disease. References of identified articles were also reviewed. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1549459DOI Listing
January 2019
9 Reads

Effect of video-assisted patient education on compliance with therapy, quality of life, psychomorbidity, and cost of illness in irritable bowel syndrome.

Postgrad Med 2019 Jan 25;131(1):60-67. Epub 2018 Nov 25.

a Department of Gastroenterology and Hepatology , Kasturba Medical College, Manipal Academy of Higher Education (MAHE) , Manipal , India.

Objective: Patient education is important in irritable bowel syndrome (IBS), but its effects on outcomes have not been studied extensively.

Methods: Patients were enrolled and prospectively divided into an interventional and usual care group. Both received standard of care, but the former additionally received video-assisted patient education. Read More

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http://dx.doi.org/10.1080/00325481.2019.1549458DOI Listing
January 2019
10 Reads
1.540 Impact Factor

Bacterial vaginosis: a primer for clinicians.

Postgrad Med 2019 Jan 30;131(1):8-18. Epub 2018 Nov 30.

b Center for Pelvic Medicine, LLC , Rosemont , PA , USA.

Bacterial vaginosis (BV) affects approximately one third of women in the United States. While often asymptomatic, BV infection may be accompanied by serious health consequences, such as preterm birth and pelvic inflammatory disease, and may facilitate acquisition of sexually transmitted infections. Identifying appropriate patients for screening, such as pregnant women, women planning pregnancy, and women with multiple and/or new sexual partners, is imperative for treatment. Read More

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http://dx.doi.org/10.1080/00325481.2019.1546534DOI Listing
January 2019
16 Reads
1.537 Impact Factor

First-generation versus second-generation drug-eluting stents in patients with chronic kidney disease: a systematic review and meta-analysis.

Postgrad Med 2019 Jan 3;131(1):43-51. Epub 2018 Dec 3.

a Department of Cardiology , Jiangmen Central Hospital , Jiangmen , China.

Background: Chronic kidney disease (CKD) patients are associated with very high rate of adverse cardiovascular outcomes after drug-eluting stents (DES) implantation. The clinical outcomes of second-generation DES versus first-generation DES in CKD patients remain controversial.

Objective: The aim of the current study was to perform a systematic review and meta-analysis to assess the safety and efficacy of second-generation DES versus first-generation DES in CKD patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546531DOI Listing
January 2019
10 Reads

Untreated depression and non-medical use of prescription pain relievers: findings from the National Survey on Drug Use and Health 2008-2014.

Postgrad Med 2019 Jan 27;131(1):52-59. Epub 2018 Nov 27.

a Department of Medicine and Surgery , University of Milano Bicocca , Monza , Italy.

Objectives: Despite growing concerns for non-medical use of prescription pain relievers (NMUPPRs), little is known about the role of comorbid, untreated depressive disorders.

Methods: We examined past year rates of NMUPPRs and major depressive episode (MDE), using data between 2008 and 2014 from the National Survey on Drug Use and Health for both youths (12-17 years) and adults (18 or older). Prevalence estimates with 95% confidence intervals were computed. Read More

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http://dx.doi.org/10.1080/00325481.2019.1546533DOI Listing
January 2019
1 Read

Venous thromboembolism prevention through the use of novel Factor Xa inhibitors.

Postgrad Med 2018 Nov 3:1-7. Epub 2018 Nov 3.

a Department of Medicine , Jersey Shore University Medical Center , Neptune , NJ , USA.

The risk of a venous thromboembolic event is not limited to the pre-hospital, hospital, or immediate post-hospital period. Because of challenges with data collection, the risk of venous thromboembolism (VTE) up to 3 months post-hospitalization for patients with acute and serious medical problems in the setting of chronic disease and/or risk factors for VTE is probably under reported. The growing acceptance and indications of direct oral anticoagulants (DOACs) now includes an indication for VTE prevention for one of the Factor Xa agents. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1542925DOI Listing
November 2018
11 Reads

Development of the Painful Periods Screening Tool for endometriosis.

Postgrad Med 2018 Nov 18;130(8):694-702. Epub 2018 Oct 18.

f Department of Obstetrics, Gynecology & Reproductive Sciences , Yale University , New Haven , CT , USA.

Objectives: Diagnostic delay is common in endometriosis. There is an unmet need for a symptom-based, patient-completed screening tool to facilitate discussions between patients and physicians about potential endometriosis symptoms. The objective of this study was to develop and assess the patient-completed Painful Periods Screening Tool (PPST) to assess the presence of potential endometriosis symptoms. Read More

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http://dx.doi.org/10.1080/00325481.2018.1526623DOI Listing
November 2018
1 Read

Taurine and aneurysmal subarachnoid hemorrhage prognosis.

Postgrad Med 2018 Nov 15;130(8):669-672. Epub 2018 Oct 15.

b Biomedical Science Institute , Autonomous University of Ciudad Juarez , Ciudad Juárez , Chihuahua , Mexico.

Despite its beneficial effects for the cardiovascular system, taurine remains a controversial substance. Taurine increases cardiac muscle strength and prevents arrhythmias, but its benefits go beyond this. Determining taurine levels may become an issue of life or death. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1533382DOI Listing
November 2018
12 Reads

Re-examining insulin compared to non-insulin therapies for type 2 diabetes: when in the disease trajectory is insulin preferable?

Postgrad Med 2018 Nov 19;130(8):653-659. Epub 2018 Oct 19.

d Department of Surgery , East Carolina University , Greenville , NC , USA.

In patients with type 2 diabetes secondary to excess nutrients and energy balance, relative - not absolute - insulin deficiency plays a key role in disease development and progression. Although patients with type 2 diabetes who have features of insulin resistance would usually have hyperinsulinemia, insulin therapy remains recommended by guidelines particularly when patients fail to achieve glycemic goals. This approach does not prevent complications particularly macrovascular complications. Read More

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http://dx.doi.org/10.1080/00325481.2018.1533381DOI Listing
November 2018
113 Reads
1.540 Impact Factor

Massive hemorrhage from a unique old cesarean scar ectopic pregnancy with negative urine and serum β-HCG: a rare case report.

Postgrad Med 2018 Nov 9;130(8):708-711. Epub 2018 Oct 9.

b Department of Pathology , Chengdu Women's and Children's Central Hospital , Chengdu , China.

Human chorionic gonadotropin (HCG) is an important indicator for the diagnosis of pregnancy. The authors report a unique case of cesarean scar ectopic pregnancy (CSEP) with negative urine and serum HCG levels, which was initially misdiagnosed as an intrauterine tumor despite the use of transvaginal ultrasound. Dilation and curettage was performed, which caused massive vaginal bleeding. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1526044DOI Listing
November 2018
6 Reads

Porphyrias and photosensitivity: pathophysiology for the clinician.

Postgrad Med 2018 Nov 23;130(8):673-686. Epub 2018 Oct 23.

a Department of Internal Medicine , Nicosia General Hospital, University of Cyprus Medical School , Nicosia , Cyprus.

Porphyrias are disorders caused by defects in the biosynthetic pathway of heme. Their manifestations can be divided into three distinct syndromes, each attributable to the accumulation of three distinct classes of molecules. The acute neurovisceral syndrome is caused by the accumulation of the neurotoxic porphyrin precursors, delta aminolevulinic acid, and porphobilinogen; the syndrome of immediate painful photosensitivity is caused by the lipid-soluble protoporphyrin IX and, the syndrome of delayed blistering photosensitivity, caused by the water-soluble porphyrins, uroporphyrin, and coproporphyrin. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1533380DOI Listing
November 2018
11 Reads

Vaginal bleeding/spotting with conjugated estrogens/bazedoxifene, conjugated estrogens/medroxyprogesterone acetate, and placebo.

Postgrad Med 2018 Nov 3;130(8):687-693. Epub 2018 Oct 3.

d US/Global Medical Affairs , Pfizer Inc , New York , NY , USA.

Objective: In the 1-year phase 3 Selective estrogens, Menopause, And Response to Therapy-5 trial, cumulative amenorrhea rates with conjugated estrogens/bazedoxifene (CE/BZA) were similar to placebo and higher than with conjugated estrogens/medroxyprogesterone acetate (CE/MPA). This post hoc analysis reports bleeding/spotting rates in 4-week intervals (cycles) and 3-month intervals (quarters) with these therapies and the percentage of cases attributable to spotting only.

Methods: Generally healthy postmenopausal women with menopausal symptoms recorded vaginal bleeding/spotting in daily diaries while receiving CE 0. Read More

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http://dx.doi.org/10.1080/00325481.2018.1520046DOI Listing
November 2018
11 Reads

Preterm and term preeclampsia: differences in biochemical parameter and pregnancy outcomes.

Postgrad Med 2018 Nov 3;130(8):703-707. Epub 2018 Oct 3.

a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.

Objective: To analyze the similarities and differences in the clinical parameters, laboratory biomarkers, and pregnancy outcomes between preterm and term preeclampsia (PE).

Methods: Data on 185 women diagnosed with PE were collected from a Jiangsu Province Hospital from January 2017 to December 2017 and analyzed. 74 (40%) patients were diagnosed with preterm PE, of which 70 (94. Read More

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http://dx.doi.org/10.1080/00325481.2018.1527169DOI Listing
November 2018
2 Reads

Beyond the new blood pressure guidelines: the beat goes on.

Postgrad Med 2018 Nov 1;130(8):666-668. Epub 2018 Oct 1.

a Cardiovascular Medicine Division , University of Puerto Rico School of Medicine , San Juan , Puerto Rico.

The scope of hypertension (HTN) even for those involved in the field is staggering with numbers close to 60 million Americans and more than 1 billion individuals across the globe. It is the most common reason to seek medical attention and according to the World Health Organization, the number one cause of mortality in the world. Yet, we still don't know what is normal or abnormal. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1526624DOI Listing
November 2018
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An alternative approach to solving the opioid epidemic: is there a role for non-pharmacologic analgesic therapies?

Authors:
Paul F White

Postgrad Med 2019 01 23;131(1):1-5. Epub 2018 Sep 23.

a Department of Anesthesiology & Pain Management , Cedars Sinai Medical Center , Los Angeles , CA , USA.

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1520589DOI Listing
January 2019
2 Reads

Emotional intelligence and leadership traits among family physicians.

Postgrad Med 2018 Sep 4;130(7):644-649. Epub 2018 Sep 4.

c Department of Family Medicine , Faculty of Medicine, Yildirim Beyazit University , Ankara , Turkey.

Objectives: High emotional intelligence and leadership traits are essential for physicians in managing their responsibilities and thus building successful interactions with patients. This study explored the relationship between emotional intelligence and leadership traits among family physicians.

Methods: Participants (2975 men, 972 women, mean = 42. Read More

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http://dx.doi.org/10.1080/00325481.2018.1515563DOI Listing
September 2018
16 Reads

Topical therapies for knee osteoarthritis.

Postgrad Med 2018 Sep 29;130(7):607-612. Epub 2018 Aug 29.

a Department of Orthopaedic Surgery , La Paz University Hospital-IdiPaz , Madrid , Spain.

Background: Symptomatic knee osteoarthritis (OA) involves millions of adults around the world.

Purpose: To analyze the effectiveness and tolerability of topical therapies and their contemporary placement in knee OA management criteria.

Methods: A Cochrane Library and PubMed (MEDLINE) search related to the role of topical therapies in knee OA was carried out. Read More

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http://dx.doi.org/10.1080/00325481.2018.1505182DOI Listing
September 2018
2 Reads

High prevalence of the risk factors for QT interval prolongation and associated drug-drug interactions in coronary care units.

Postgrad Med 2018 Nov 5;130(8):660-665. Epub 2018 Sep 5.

c Department of Medicine , Khyber Teaching Hospital , Peshawar , Pakistan.

Objectives: Patients admitted in coronary care units are susceptible to QT interval prolongation due to numerous risk factors. The purpose of this study was to identify the prevalence of risk factors for QT interval prolongation; QT prolonging medications; drug-drug interactions; their predictors; and torsades de pointes risks of drugs.

Methods: After obtaining approval, this cross-sectional study was carried out during one-year period in coronary care units of two major tertiary care hospitals of Khyber Pakhtunkhwa, Pakistan. Read More

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http://dx.doi.org/10.1080/00325481.2018.1516106DOI Listing
November 2018
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Progression to chronic kidney disease in patients undergoing nephrectomy for small renal masses: a price to pay for a therapeutic success?

Postgrad Med 2018 Sep 27;130(7):613-620. Epub 2018 Aug 27.

a 2nd Department of Nephrology , Medical University of Bialystok , Bialystok , Poland.

Nephrectomy, which constitutes a gold-standard procedure for the treatment of renal-cell carcinoma (RCC), has been widely discussed in the past decade as a significant risk factor of the development of chronic kidney disease (CKD). RCC is the third most common genitourinary cancer in the United States, with an estimated more than 65,000 new cases and 14,970 deaths. The aim of this review was to precisely and comprehensively summarize the status of current knowledge in CKD risk factors after nephrectomy, the advantages of minimally invasive vs. Read More

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http://dx.doi.org/10.1080/00325481.2018.1511211DOI Listing
September 2018
3 Reads

Risk factors for latent tuberculosis infection in children in South Korea.

Postgrad Med 2018 Sep 22;130(7):637-643. Epub 2018 Aug 22.

a Department of Pediatrics, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Objectives: In South Korea, latent tuberculosis infection (LTBI) screening is a critical strategy associated with efforts to reduce the incidence of tuberculosis (TB). Currently, only children with a known history of TB contact are considered as pediatric high-risk groups for LTBI, and consequently, LTBI screening is only provided to these children. However, to reduce the incidence of TB, the high-risk groups that undergo LTBI screening should be expanded. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1510709DOI Listing
September 2018
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Typhlitis as a complication of influenza in a patient with advanced HIV infection.

Postgrad Med 2018 Sep 11;130(7):650-651. Epub 2018 Aug 11.

c Hospital of Virnaroz , Castellon , Spain.

The authors report the case of an HIV-infected patient who presented with typhlitis as a complication of typical influenza. To the best of their knowledge, this is the first case reported in the literature with such an association of clinical conditions. Read More

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http://dx.doi.org/10.1080/00325481.2018.1508984DOI Listing
September 2018
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The impact of residential medication management reviews (RMMRs) on medication regimen complexity.

Postgrad Med 2018 Aug 9;130(6):575-579. Epub 2018 Aug 9.

d University of Sydney - School of Nursing , Sydney , Australia.

Objectives: The primary objective of this study was to investigate the impact of RMMRs on medication regimen complexity, as assessed by a validated measure.

Methods: Retrospective analysis of RMMRs pertaining to 285 aged care residents aged ≥ 65 years in Sydney, Australia. Medication regimen complexity was measured using the Medication Regimen Complexity Index (MRCI) at baseline, after pharmacists' recommendations (assuming that all of the pharmacists' recommendations were accepted by the General Practitioner (GP)), and after the actual uptake of pharmacists' recommendations by the GP. Read More

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http://dx.doi.org/10.1080/00325481.2018.1502016DOI Listing
August 2018
3 Reads

Clinical manifestations of granulomatosis with polyangiitis: key considerations and major features.

Postgrad Med 2018 Sep 2;130(7):581-596. Epub 2018 Aug 2.

a Department of Rheumatology and Internal Medicine , Poznan University of Medical Sciences , Poznan , Poland.

Background: Granulomatosis with polyangiitis (GPA) presents a wide spectrum of manifestations from the common respiratory symptoms to infrequent neurological and cardiac complications. The challenge in diagnosis and management makes the rapidly progressive disorder one of the most challenging dilemmas in clinical medicine.

Method: An extensive electronic literature search was done using multiple databases (e. Read More

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http://dx.doi.org/10.1080/00325481.2018.1503920DOI Listing
September 2018
4 Reads

Fecal markers in the management of inflammatory bowel disease.

Postgrad Med 2018 Sep 31;130(7):597-606. Epub 2018 Jul 31.

a Department of Gastroenterology, First Affiliated Hospital , China Medical University , Shenyang , China.

Inflammatory bowel disease (IBD) is characterized by periods of symptomatic remission and relapse. Diagnosis and assessment of IBD are based on clinical evaluation, serum parameters, radiology, and endoscopy. Fecal markers have emerged as new diagnostic tools to detect and monitor intestinal inflammation. Read More

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http://dx.doi.org/10.1080/00325481.2018.1503919DOI Listing
September 2018
30 Reads

Cost-effectiveness of pharmaceutical care on patients undergoing maintenance hemodialysis - a multicenter randomized controlled study.

Postgrad Med 2018 Sep 2;130(7):621-626. Epub 2018 Aug 2.

c Department of Nephrology , Kasturba Medical College, Kasturba Hospital , MAHE , Manipal , India.

Objectives: The aim of the study is to assess the cost-effectiveness of pharmaceutical care versus usual care on the treatment costs in patients undergoing maintenance hemodialysis (HD) in the outpatient HD centers of academic, government, and corporate hospitals.

Methods: An open-labeled randomized controlled study was registered under clinical trial registry of India (Ref. no. Read More

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http://dx.doi.org/10.1080/00325481.2018.1504595DOI Listing
September 2018
4 Reads

Combining prescription monitoring, benchmarking, and educational interventions to reduce benzodiazepine prescriptions among internal medicine inpatients; a multicenter before and after study in a network of Swiss Public Hospitals.

Postgrad Med 2018 Sep 2;130(7):627-636. Epub 2018 Aug 2.

a Department of Internal Medicine and Nephrology , Regional Hospital of Bellinzona and Valli, Ente Ospedaliero Cantonale , Bellinzona , Switzerland.

Objectives: Reducing the inappropriate benzodiazepine (BZD) prescriptions represents a challenge for health care systems worldwide. The 'Choosing Wisely' campaign recommends against the use of BZD in the elderly as the first choice for insomnia, agitation, or delirium. We aimed to determine whether a transparent monitoring-benchmarking together with educational interventions, on top of the internal publication of a targeted recommendation, could be effective in curbing BZD prescriptions. Read More

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http://dx.doi.org/10.1080/00325481.2018.1504594DOI Listing
September 2018
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Abuse of immediate-release opioids and current approaches to reduce misuse, abuse, and diversion.

Postgrad Med 2018 Jul 26:1-7. Epub 2018 Jul 26.

b Department of Pain Management , Carolinas Pain Center , Huntersville , NC , USA.

Deaths from opioid overdoses have increased dramatically over the past few years. Given that immediate-release (IR) opioids account for most of the U.S. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1502569DOI Listing
July 2018
6 Reads