15,101 results match your criteria Postgraduate Medicine [Journal]


SGLT2 inhibitors in patients with type 2 diabetes and renal disease: overview of current evidence.

Authors:
Jaime A Davidson

Postgrad Med 2019 Mar 30:1-10. Epub 2019 Mar 30.

a The University of Texas Southwestern Medical Center, Touchstone Diabetes Center , Dallas , TX , USA.

Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and is associated with poor clinical outcomes, including an increased risk of all-cause and cardiovascular mortality, as well as adverse economic and social effects. Slowing the development and progression of CKD remains an unmet clinical need in patients with T2DM. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are widely used for the management of T2DM and have effects beyond glucose lowering that include cardiovascular benefits and potential renoprotective effects. Read More

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http://dx.doi.org/10.1080/00325481.2019.1601404DOI Listing

Hyperchloremic metabolic acidosis in the kidney transplant patient.

Postgrad Med 2019 Apr 29;131(3):171-175. Epub 2019 Mar 29.

a Human Physiology Department , Instituto Universitario del Hospital Italiano de Buenos Aires , Buenos Aires , Argentina.

Hyperchloremic metabolic acidosis of renal origin results from a defect in renal tubular acidification mechanism, and this tubular dysfunction can consist of an altered tubular proton secretion or bicarbonate reabsorption capability. Studies have documented that all forms of renal tubular acidosis (RTA), type I to IV, are documented in kidney transplant patients. Among RTA pathophysiologic mechanisms have been described the renal mass reduction, hyperkalemia, hyperparathyroidism, graft rejection, immunologic diseases, and some drugs such as renin-angiotensin-aldosterone blockers, and calcineurin inhibitors. Read More

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http://dx.doi.org/10.1080/00325481.2019.1592360DOI Listing
April 2019
1 Read

Inflammatory profile in optimally treated patients with adult versus early-onset asthma.

Postgrad Med 2019 Mar 28:1-6. Epub 2019 Mar 28.

a 2nd Respiratory Medicine Department , University of Athens Medical School , Athens , Greece.

Introduction: The age of asthma onset is often implicated in clinical manifestation, diagnosis, and management of the disease.

Aim: To define demographic, clinical and functional features and inflammatory characteristics in induced sputum in patients with adult-onset asthma.

Methods: Optimally treated patients from asthma clinics of two tertiary hospitals were included in the study. Read More

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http://dx.doi.org/10.1080/00325481.2019.1600884DOI Listing
March 2019
1 Read

A proposed definition of remission from chronic pain, based on retrospective evaluation of 24-month outcomes with spinal cord stimulation.

Postgrad Med 2019 Mar 22:1-9. Epub 2019 Mar 22.

h Department of Research , Medical Consulting in Pain and Neuromodulation , San Francisco , CA , USA.

Objective: In the treatment of chronic diseases, remission is commonly used as a meaningful treatment goal, synonymous with the absence of significant clinical signs and symptoms of a disease, but not representing a cure. The objective of this paper is to propose a definition for remission for use as an outcome to evaluate the long-term efficacy of therapies for chronic pain.

Methods: Data from a randomized clinical trial (NCT01609972) testing the efficacy of spinal cord stimulation in low back and leg pain subjects was used to evaluate the association between pain and functional outcomes and identify the cut-off value to predict remission. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1592401DOI Listing
March 2019
5 Reads

Pulmonary lymphangitis carcinomatosis: systematic review and meta-analysis of case reports, 1970-2018.

Authors:
Monika Klimek

Postgrad Med 2019 Mar 22:1-10. Epub 2019 Mar 22.

a Department of Laboratory Diagnostics , Medical University of Lublin , Lublin , Poland.

Pulmonary lymphangitis carcinomatosis (PLC) is a life-threating complication in patients suffering from malignancies. Misleading and nonspecific symptoms often result in a delayed diagnosis. This review was aimed at evaluating epidemiology, clinical manifestations, and survival of patients with PLC reported in the literature. Read More

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http://dx.doi.org/10.1080/00325481.2019.1595982DOI Listing
March 2019
3 Reads

Estimate of reduced glomerular filtration rate by triglyceride-glucose index: insights from a general Chinese population.

Postgrad Med 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Department of Cardiology , The First Affiliated Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.

Objectives: Recent studies have identified triglyceride-glucose index (TyG) as a surrogate of insulin resistance. Since insulin resistance correlates with renal damage, our study aims to investigate the impact of TyG on the risk of reduced eGFR and explore its value to improve the risk stratification and prevention of reduced eGFR.

Methods: This cross-sectional study included 6466 participants (mean age:59. Read More

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http://dx.doi.org/10.1080/00325481.2019.1595983DOI Listing

Pulmonary complications of influenza infection: a targeted narrative review.

Postgrad Med 2019 Mar 8:1-10. Epub 2019 Mar 8.

a Division of Pulmonary, Critical Care and Sleep Medicine , Wayne State University, School of Medicine , Detroit , MI , USA.

Severe influenza infection represents a leading cause of global morbidity and mortality. Several clinical syndromes that involve a number of organs may be associated with Influenza infection. However, lower respiratory complications remain the most common and serious sequel of influenza infection. Read More

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http://dx.doi.org/10.1080/00325481.2019.1592400DOI Listing
March 2019
11 Reads

Heart failure readmissions: a losing battle or an opportunity for improvement?

Postgrad Med 2019 Apr 7;131(3):182-184. Epub 2019 Mar 7.

b Cardiovascular Medicine Division of the University of Puerto Rico School of Medicine , San Juan , Puerto Rico.

Despite great strides in diagnosis and management of heart failure (HF), this chronic illness continues to be a worldwide epidemic with approximately 23 million people afflicted across the globe. In the US, over 6.5 million carry a HF diagnosis with almost 90% of all HF deaths occurring in patients over the age of 70. Read More

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http://dx.doi.org/10.1080/00325481.2019.1589154DOI Listing

High-frequency spinal cord stimulation at 10 kHz for widespread pain: a retrospective survey of outcomes from combined cervical and thoracic electrode placements.

Authors:
John Salmon

Postgrad Med 2019 Apr 1;131(3):230-238. Epub 2019 Apr 1.

a PainCare Perth , Parkland House , Cottesloe , Australia.

Objective: To report on the long-term outcomes for patients receiving paraesthesia-free high-frequency spinal cord stimulation (HF10-SCS) at 10 kHz for the treatment of combined upper and lower body neuropathic/nociplastic pain syndromes including chronic widespread pain/fibromyalgia.

Materials And Methods: Forty-five patients with widespread (both upper and lower body) neuropathic/nociplastic pain syndromes underwent a trial of combined cervical and thoracic HF10-SCS leads placed over the C2/T2 or C2/T9 vertebral levels, or three leads placed over the C2/T2/T9 vertebral levels. Thirty-eight patients proceeded to permanent implant, resulting in a trial to implant conversion rate of 84. Read More

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http://dx.doi.org/10.1080/00325481.2019.1587564DOI Listing
April 2019
3 Reads

Correlation between hypocalcemia and acute exacerbation of chronic obstructive pulmonary disease in the elderly.

Postgrad Med 2019 Mar 4:1-5. Epub 2019 Mar 4.

a Department of Clinical Laboratory , The First Affiliated Hospital of Guangxi Medical University , Nanning , Guangxi Zhuang Autonomous Region , China.

Introduction: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an important disease of hospitalized elderly patients, who often have electrolyte imbalances. This study was performed to analyze total serum calcium levels in elderly patients with AECOPD and identify the correlation between hypocalcemia and AECOPD.

Methods: 153 elderly patients with AECOPD served as the observation group, and 115 healthy elderly people undergoing physical examinations served as the control group. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585689DOI Listing

The prognostic impact of TP53 comutation in EGFR mutant lung cancer patients: a systematic review and meta-analysis.

Postgrad Med 2019 Apr 15;131(3):199-206. Epub 2019 Mar 15.

a Department of Respiratory and Critical Care Medicine , West China Hospital, Sichuan University , Chengdu , Sichuan , China.

Background The prognostic value of TP53 commutation in epidermal growth factor receptor (EGFR) mutant lung cancer is controversial and we therefore conducted this systematic review and meta-analysis. Methods A systematic search was carried out in Pubmed, Web of Science, the Cochrane Library, Medline and Embase up to 19 April 2018. The pooled hazard ratio (HR) of overall survival (OS) and progression-free survival (PFS), the relative risk (RR) of objective response rate (ORR) were calculated. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585690DOI Listing
April 2019
1 Read

Real-world misuse, abuse, and dependence of abuse-deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.

Postgrad Med 2019 Apr 19;131(3):225-229. Epub 2019 Mar 19.

j Medical Affairs , Pfizer Inc. , New York , NY , USA.

Objective: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients.

Methods: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from 1 January 2015, to 30 June 2016. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585688DOI Listing
April 2019
4 Reads

SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses.

Postgrad Med 2019 Mar;131(2):82-88

b Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.

Sodium-glucose co-transporter 2 (SGLT2) inhibitors inhibit glucose re-absorption in the proximal renal tubules. Two trials have shown significant reductions of cardiovascular (CV) events with empagliflozin and canagliflozin, which could not be attributed solely to their antidiabetic effects. The aim of the review is the critical presentation of suggested mechanisms/hypotheses for the SGLT2 inhibitors' cardioprotection. Read More

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http://dx.doi.org/10.1080/00325481.2019.1581971DOI Listing
March 2019
2 Reads

Management of hypoglycemia in older adults with type 2 diabetes.

Authors:
Jeffrey Freeman

Postgrad Med 2019 Feb 26:1-10. Epub 2019 Feb 26.

a Department of Internal Medicine, Division of Endocrinology and Metabolism , Philadelphia College of Osteopathic Medicine , Philadelphia , PA , USA.

Treatment of older adults with type 2 diabetes (T2D) is complex because they represent a heterogeneous group with a broad range of comorbidities, functional abilities, socioeconomic status, and life expectancy. Older adults with T2D are at high risk of recurring hypoglycemia, a condition associated with marked morbidity and mortality, because their counter-regulatory mechanism to hypoglycemia is attenuated, and recurring hypoglycemic episodes can lead to hypoglycemia unawareness. In addition, polypharmacy, a result of multiple chronic comorbidities (including heart disease, stroke, and chronic kidney disease), can increase the risk of severe hypoglycemia, especially when patients are taking sulfonylureas or insulin. Read More

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http://dx.doi.org/10.1080/00325481.2019.1578590DOI Listing
February 2019
2 Reads

Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management.

Postgrad Med 2019 Apr 11;131(3):185-198. Epub 2019 Feb 11.

c School of Nursing , Linfield College , Portland , OR , USA.

Chronic pain is a common public health problem that has a detrimental impact on patient health, quality of life (QoL), and function, and poses a substantial socioeconomic burden. Evidence supports the redefinition of chronic pain as a distinct disease entity, not simply a symptom of injury or illness. Chronic pain conditions are characterized by three types of pain pathophysiology (i. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1574403DOI Listing
April 2019
23 Reads

Apremilast efficacy and safety in a psoriatic arthritis patient affected by HIV and HBV virus infections.

Postgrad Med 2019 Apr 8;131(3):239-240. Epub 2019 Feb 8.

a Department of Dermatology , University of Rome "Tor Vergata" , Rome , Italy.

Treatment of psoriasis and psoriatic arthritis in patients with concomitant chronic, severe viral infections, particularly HIV or HBV, represents a challenge, due to contraindication to conventional immunomodulating systemic drugs and biologics, including anti-TNF alpha, anti-IL12/23, and anti-IL17 agents. Recently, apremilast, a selective inhibitor of phosphodiesterase E4 has been suggested to be a safe and effective therapeutic option in HIV-infected population with psoriatic arthritis. We report the case of a patient with psoriatic arthritis and concomitant HIV and HBV infection successfully treated with apremilast. Read More

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http://dx.doi.org/10.1080/00325481.2019.1575613DOI Listing
April 2019
1 Read

Pharmacokinetic and pharmacodynamic differences of new generation, longer-acting basal insulins: potential implications for clinical practice in type 2 diabetes.

Postgrad Med 2019 Mar 11;131(2):117-128. Epub 2019 Feb 11.

e Department of Medicine , Perugia University Medical School, Hospital Santa Maria della Misericordia , Perugia , Italy.

The treatment of type 2 diabetes (T2D) is often complicated by factors such as patient co-morbidities, complex drug-drug interactions, and management of adverse events. In addition, some of these factors are highly dependent on the nature of the treatment regimen and the molecular and physical properties of the drugs being used to treat patients with this disease. This calls for a better understanding of how the properties of individual drugs affect the overall outcome for patients with diabetes. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568136DOI Listing

A randomized, double-blind, 3-way crossover, analog classroom study of SHP465 mixed amphetamine salts extended-release in adolescents with ADHD.

Postgrad Med 2019 Apr 18;131(3):212-224. Epub 2019 Feb 18.

f Global Medical Affairs , Shire, a member of the Takeda group of companies , Lexington , MA , USA.

Objectives: To evaluate the duration of efficacy, safety, and tolerability of SHP465 mixed amphetamine salts (MAS) extended-release versus placebo and immediate-release MAS (MAS IR) in adolescents with attention-deficit/hyperactivity disorder (ADHD).

Methods: This phase 2, randomized, 3-period, 3-treatment crossover study compared SHP465 MAS (25/50 mg) with placebo and MAS IR (12.5 mg) in 13-17-year-old adolescents with ADHD having ADHD Rating Scale, Version IV (ADHD-RS-IV) total scores ≥24. Read More

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http://dx.doi.org/10.1080/00325481.2019.1574402DOI Listing
April 2019
13 Reads

A proposed anti-maladaptive aggression agent classification: improving our approach to treating impulsive aggression.

Postgrad Med 2019 Mar 14;131(2):129-137. Epub 2019 Feb 14.

f Psychiatry and Behavioral Sciences , Johns Hopkins University , Baltimore , MD , USA.

Proper drug categorization enables clinicians to readily identify the agents most appropriate for patients in need. Currently, patients with maladaptive aggression do not all always fall into a single existing diagnostic or treatment category. Such is the case for those with impulsive aggression (IA). Read More

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http://dx.doi.org/10.1080/00325481.2019.1574401DOI Listing
March 2019
1 Read

Early and late relapses of cutaneous melanoma patients.

Postgrad Med 2019 Apr 28;131(3):207-211. Epub 2019 Jan 28.

a Department of Medical Oncology, Institute of Oncology , University of Istanbul , Istanbul , Turkey.

Objectives: Recurrence may most likely develop during the course of the disease in patients presented with early stage melanoma at initial diagnosis. The specific risk factors for early and late recurrences following definitive surgical excision have yet to be determined. The aim of this study was to analyze the early and late relapses in stage I-III cutaneous melanoma patients. Read More

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http://dx.doi.org/10.1080/00325481.2019.1569354DOI Listing
April 2019
1 Read

High burden and low awareness of toxoplasmosis in the United States.

Postgrad Med 2019 Mar 21;131(2):103-108. Epub 2019 Jan 21.

b Unit of PharmacoEpidemiology & PharmacoEconomics, Department of Pharmacy , University of Groningen , Groningen , The Netherlands.

Toxoplasmosis, a disease with diverse clinical manifestations, caused by infection with the Apicomplexan parasite, Toxoplasma gondii (T. gondii), is a major source of morbidity and mortality in the United States. Although toxoplasmosis prevalence and mortality have declined over the past two decades, the CDC considers this disease a neglected parasitic infection requiring public health action. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1568792DOI Listing
March 2019
3 Reads

Impact of treatment modality on clinical outcome in metastatic colorectal cancer patients stratified by metastatic sites.

Postgrad Med 2019 Mar 21;131(2):163-170. Epub 2019 Jan 21.

a Institute of Medicine , Chung Shan Medical University , Taichung , Taiwan.

Objectives: To investigate the impact of location of metastases, and therapeutic modality on clinical outcomes in patients with metastatic colorectal cancer (CRC).

Methods: Data for metastatic CRC patients were sourced from the Surveillance, Epidemiology, and End Results (SEER) database (SEER ID: 15309-Nov2017). Patients were classified as follows: Group 1 patients had only liver metastasis; Group 2 patients had liver and lung metastasis; Group 3 patients had more than two metastasis sites. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568016DOI Listing
March 2019
1 Read

The single use of body mass index for the obesity paradox is misleading and should be used in conjunction with other obesity indices.

Postgrad Med 2019 Mar 6;131(2):96-102. Epub 2019 Feb 6.

b Department of Cardiology , INTEGRIS Baptist Medical Center , Oklahoma City , OK , USA.

Overweight and obesity in children and adults have significantly risen in the US and worldwide due to biological, environmental, and cultural drivers and account for about 2.1 billion people. In addition, obesity, even metabolically healthy, is a major risk factor for the metabolic syndrome, diabetes mellitus, dyslipidemia, and hypertension, all significant causes of cardiovascular disease (CVD), coronary heart disease (CHD) heart failure (HF) and stroke. Read More

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http://dx.doi.org/10.1080/00325481.2019.1568019DOI Listing
March 2019
6 Reads

Multifocal gastrointestinal varices: a rare manifestation of immunoglobulin G4-related disease.

Postgrad Med 2019 Apr 29;131(3):176-181. Epub 2019 Jan 29.

a Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine , National Cheng Kung University , Tainan , Taiwan.

Multifocal gastrointestinal varices are uncommon and often associated with liver cirrhosis. They consist of varices at the gastroesophageal region and the other sites (i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1568018DOI Listing
April 2019
11 Reads

Cardio-oncology: in search of the right balance.

Postgrad Med 2019 03 24;131(2):79-81. Epub 2019 Jan 24.

a Cardiovascular Medicine Division , University of Puerto Rico School of Medicine , San Juan , Puerto Rico.

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http://dx.doi.org/10.1080/00325481.2019.1568020DOI Listing
March 2019
1 Read

Treating patients with pain: how to make it less painful.

Postgrad Med 2019 01 9;131(1):6-7. Epub 2019 Jan 9.

a VA Connecticut Healthcare System , Yale University School of Medicine , West Haven , CT , USA.

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http://dx.doi.org/10.1080/00325481.2019.1563370DOI Listing
January 2019
1 Read

One-stage posterior approach for treating multilevel noncontiguous thoracic and lumbar spinal tuberculosis.

Postgrad Med 2019 Jan 26;131(1):73-77. Epub 2018 Dec 26.

b Department of Orthopaedic , Third Affiliated Hospital of Southern Medical University , Guangzhou , PR China.

Objectives: Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumentation, is effective for treating MNST.

Methods: Thirteen patients, with an average age of 40. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552824DOI Listing
January 2019
4 Reads
1.537 Impact Factor

Babesiosis as a cause of acute respiratory distress syndrome: a series of eight cases.

Postgrad Med 2019 Mar 26;131(2):138-143. Epub 2018 Dec 26.

a Division of Pulmonary, Critical Care, and Sleep Medicine , Westchester Medical Center , Valhalla , NY , USA.

Objectives: The characteristics of patients with Acute Respiratory Distress Syndrome (ARDS) as a complication of Babesia microti infection have not been systematically described.

Methods: Adult patients admitted to the medical intensive care unit (MICU) of a tertiary care hospital in the Lower Hudson Valley of New York from 1/1/2008 to 8/1/2016 were evaluated for ARDS complicating babesiosis.

Results: Of 22 patients with babesiosis in the MICU, eight (36. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1558910DOI Listing
March 2019
21 Reads

Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?

Postgrad Med 2019 Mar 16;131(2):109-116. Epub 2019 Jan 16.

b Global Medical Affairs , Pfizer Consumer Healthcare , Sao Paulo , Brazil.

Consensus guidelines for treatment of dengue fever from the World Health Organization and US Centers for Disease Control recommend acetaminophen to manage pain and fever but contraindicate nonsteroidal anti-inflammatory agents (NSAIDs) because of potentially increased bleeding risk, with thrombocytopenia as a complication. Neither acetaminophen nor ibuprofen (the NSAID with lowest bleeding risk) have been evaluated for dengue treatment in randomized, controlled clinical trials. Epidemiologic and cohort studies and case series describing NSAID use in dengue generally point to minimal or no significant increase in bleeding risk, except for aspirin. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1561916DOI Listing
March 2019
10 Reads

Circulating levels of prolactin are elevated in patients with rheumatoid arthritis: a meta-analysis.

Postgrad Med 2019 Mar 20;131(2):156-162. Epub 2018 Dec 20.

a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , Anhui , China.

Background: Prolactin (PRL), an inflammatory hormone with cytokine properties, has long been proposed to play a crucial role in the pathogenesis of autoimmune disorders, including rheumatoid arthritis (RA). However, the circulating levels of PRL in RA were discordant among published studies.

Methods: PubMed, Embase, and The Cochrane Library database were systematically searched from inception up to 30 June 2018. Read More

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http://dx.doi.org/10.1080/00325481.2019.1559430DOI Listing
March 2019
1 Read

Early age at menarche is associated with insulin resistance: a systemic review and meta-analysis.

Postgrad Med 2019 Mar 26;131(2):144-150. Epub 2018 Dec 26.

a Department of Cardiology, West China Hospital , Sichuan University , Chengdu , China.

Objectives: We aimed to conduct a systemic review and meta-analysis of the relevant studies to further investigate the association between age at menarche and insulin resistance.

Methods: PubMed, EMBASE, and Web of Science (SCI) databases were systemically searched until December 2017. Observational studies comparing the incidences of insulin resistance in patients with early, average, and late menarchal ages were identified. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1559429DOI Listing
March 2019
5 Reads

Clinical analysis of false-negative fine needle aspiration cytology of head and neck cancers.

Postgrad Med 2019 Mar 17;131(2):151-155. Epub 2018 Dec 17.

a Department of Otorhinolaryngology/Head & Neck Surgery , Hamamatsu University School of Medicine , Hamamatsu , Japan.

Background: Fine-needle aspiration (FNA) cytology is frequently used for initial and/or preoperative diagnosis of tumors in the head and neck region. However, false-negative results can lead to misdiagnosis. The aim of this study was to investigate the diagnostic results of FNA in the head and neck region and the reasons for false-negative cases. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1559431DOI Listing
March 2019
20 Reads

MEFV gene variants in children with Henoch-Schönlein purpura and association with clinical manifestations: a single-center Mediterranean experience.

Postgrad Med 2019 Jan 12;131(1):68-72. Epub 2018 Dec 12.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain, and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without Familial Mediterranean Fever (FMF) symptoms and followed for at least 6 months. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552479DOI Listing
January 2019
10 Reads

Clinical workup of fatty liver for the primary care provider.

Postgrad Med 2019 Jan 29;131(1):19-30. Epub 2018 Nov 29.

d Department of Gastroenterology , University of Colorado Denver , Aurora , CO , USA.

Nonalcoholic fatty liver disease (NAFLD) is quickly emerging as a global epidemic in parallel with the rise in obesity and the Metabolic Syndrome. NAFLD, once seen simply as a passive consequence of the Metabolic Syndrome (MetS), has been found to interact with other features of MetS to exacerbate insulin resistance, diabetes, and cardiovascular disease. NAFLD is also becoming the top indication for liver transplant and an important risk factor for hepatocellular carcinoma. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546532DOI Listing
January 2019
26 Reads

Efficacy and renal outcomes of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease.

Postgrad Med 2019 Jan 30;131(1):31-42. Epub 2018 Nov 30.

d Chapman University , Orange , CA , USA.

Objective: To review glucose-lowering efficacy and changes in renal function associated with sodium-glucose co-transporter 2 (SGLT2) inhibitors among patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).

Data Sources: A literature search of MEDLINE and Cochrane databases was performed from 2000 to August 2018 using search terms: SGLT2 inhibitors, sodium glucose co-transporter 2, canagliflozin, empagliflozin, dapagliflozin, ertugliflozin, and chronic kidney disease. References of identified articles were also reviewed. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1549459DOI Listing
January 2019
14 Reads

Effect of video-assisted patient education on compliance with therapy, quality of life, psychomorbidity, and cost of illness in irritable bowel syndrome.

Postgrad Med 2019 Jan 25;131(1):60-67. Epub 2018 Nov 25.

a Department of Gastroenterology and Hepatology , Kasturba Medical College, Manipal Academy of Higher Education (MAHE) , Manipal , India.

Objective: Patient education is important in irritable bowel syndrome (IBS), but its effects on outcomes have not been studied extensively.

Methods: Patients were enrolled and prospectively divided into an interventional and usual care group. Both received standard of care, but the former additionally received video-assisted patient education. Read More

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http://dx.doi.org/10.1080/00325481.2019.1549458DOI Listing
January 2019
14 Reads
1.540 Impact Factor

Bacterial vaginosis: a primer for clinicians.

Postgrad Med 2019 Jan 30;131(1):8-18. Epub 2018 Nov 30.

b Center for Pelvic Medicine, LLC , Rosemont , PA , USA.

Bacterial vaginosis (BV) affects approximately one third of women in the United States. While often asymptomatic, BV infection may be accompanied by serious health consequences, such as preterm birth and pelvic inflammatory disease, and may facilitate acquisition of sexually transmitted infections. Identifying appropriate patients for screening, such as pregnant women, women planning pregnancy, and women with multiple and/or new sexual partners, is imperative for treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546534DOI Listing
January 2019
23 Reads
1.537 Impact Factor

First-generation versus second-generation drug-eluting stents in patients with chronic kidney disease: a systematic review and meta-analysis.

Postgrad Med 2019 Jan 3;131(1):43-51. Epub 2018 Dec 3.

a Department of Cardiology , Jiangmen Central Hospital , Jiangmen , China.

Background: Chronic kidney disease (CKD) patients are associated with very high rate of adverse cardiovascular outcomes after drug-eluting stents (DES) implantation. The clinical outcomes of second-generation DES versus first-generation DES in CKD patients remain controversial.

Objective: The aim of the current study was to perform a systematic review and meta-analysis to assess the safety and efficacy of second-generation DES versus first-generation DES in CKD patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546531DOI Listing
January 2019
10 Reads

Untreated depression and non-medical use of prescription pain relievers: findings from the National Survey on Drug Use and Health 2008-2014.

Postgrad Med 2019 Jan 27;131(1):52-59. Epub 2018 Nov 27.

a Department of Medicine and Surgery , University of Milano Bicocca , Monza , Italy.

Objectives: Despite growing concerns for non-medical use of prescription pain relievers (NMUPPRs), little is known about the role of comorbid, untreated depressive disorders.

Methods: We examined past year rates of NMUPPRs and major depressive episode (MDE), using data between 2008 and 2014 from the National Survey on Drug Use and Health for both youths (12-17 years) and adults (18 or older). Prevalence estimates with 95% confidence intervals were computed. Read More

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http://dx.doi.org/10.1080/00325481.2019.1546533DOI Listing
January 2019
1 Read

Venous thromboembolism prevention through the use of novel Factor Xa inhibitors.

Postgrad Med 2019 Mar 28;131(2):89-95. Epub 2018 Nov 28.

a Department of Medicine , Jersey Shore University Medical Center , Neptune , NJ , USA.

The risk of a venous thromboembolic event is not limited to the pre-hospital, hospital, or immediate post-hospital period. Because of challenges with data collection, the risk of venous thromboembolism (VTE) up to 3 months post-hospitalization for patients with acute and serious medical problems in the setting of chronic disease and/or risk factors for VTE is probably under reported. The growing acceptance and indications of direct oral anticoagulants (DOACs) now includes an indication for VTE prevention for one of the Factor Xa agents. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1542925DOI Listing
March 2019
14 Reads

Development of the Painful Periods Screening Tool for endometriosis.

Postgrad Med 2018 Nov 18;130(8):694-702. Epub 2018 Oct 18.

f Department of Obstetrics, Gynecology & Reproductive Sciences , Yale University , New Haven , CT , USA.

Objectives: Diagnostic delay is common in endometriosis. There is an unmet need for a symptom-based, patient-completed screening tool to facilitate discussions between patients and physicians about potential endometriosis symptoms. The objective of this study was to develop and assess the patient-completed Painful Periods Screening Tool (PPST) to assess the presence of potential endometriosis symptoms. Read More

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http://dx.doi.org/10.1080/00325481.2018.1526623DOI Listing
November 2018
2 Reads

Taurine and aneurysmal subarachnoid hemorrhage prognosis.

Postgrad Med 2018 Nov 15;130(8):669-672. Epub 2018 Oct 15.

b Biomedical Science Institute , Autonomous University of Ciudad Juarez , Ciudad Juárez , Chihuahua , Mexico.

Despite its beneficial effects for the cardiovascular system, taurine remains a controversial substance. Taurine increases cardiac muscle strength and prevents arrhythmias, but its benefits go beyond this. Determining taurine levels may become an issue of life or death. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1533382DOI Listing
November 2018
15 Reads

Re-examining insulin compared to non-insulin therapies for type 2 diabetes: when in the disease trajectory is insulin preferable?

Postgrad Med 2018 Nov 19;130(8):653-659. Epub 2018 Oct 19.

d Department of Surgery , East Carolina University , Greenville , NC , USA.

In patients with type 2 diabetes secondary to excess nutrients and energy balance, relative - not absolute - insulin deficiency plays a key role in disease development and progression. Although patients with type 2 diabetes who have features of insulin resistance would usually have hyperinsulinemia, insulin therapy remains recommended by guidelines particularly when patients fail to achieve glycemic goals. This approach does not prevent complications particularly macrovascular complications. Read More

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http://dx.doi.org/10.1080/00325481.2018.1533381DOI Listing
November 2018
127 Reads
1.540 Impact Factor

Massive hemorrhage from a unique old cesarean scar ectopic pregnancy with negative urine and serum β-HCG: a rare case report.

Postgrad Med 2018 Nov 9;130(8):708-711. Epub 2018 Oct 9.

b Department of Pathology , Chengdu Women's and Children's Central Hospital , Chengdu , China.

Human chorionic gonadotropin (HCG) is an important indicator for the diagnosis of pregnancy. The authors report a unique case of cesarean scar ectopic pregnancy (CSEP) with negative urine and serum HCG levels, which was initially misdiagnosed as an intrauterine tumor despite the use of transvaginal ultrasound. Dilation and curettage was performed, which caused massive vaginal bleeding. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1526044DOI Listing
November 2018
6 Reads

Porphyrias and photosensitivity: pathophysiology for the clinician.

Postgrad Med 2018 Nov 23;130(8):673-686. Epub 2018 Oct 23.

a Department of Internal Medicine , Nicosia General Hospital, University of Cyprus Medical School , Nicosia , Cyprus.

Porphyrias are disorders caused by defects in the biosynthetic pathway of heme. Their manifestations can be divided into three distinct syndromes, each attributable to the accumulation of three distinct classes of molecules. The acute neurovisceral syndrome is caused by the accumulation of the neurotoxic porphyrin precursors, delta aminolevulinic acid, and porphobilinogen; the syndrome of immediate painful photosensitivity is caused by the lipid-soluble protoporphyrin IX and, the syndrome of delayed blistering photosensitivity, caused by the water-soluble porphyrins, uroporphyrin, and coproporphyrin. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1533380DOI Listing
November 2018
11 Reads

Vaginal bleeding/spotting with conjugated estrogens/bazedoxifene, conjugated estrogens/medroxyprogesterone acetate, and placebo.

Postgrad Med 2018 Nov 3;130(8):687-693. Epub 2018 Oct 3.

d US/Global Medical Affairs , Pfizer Inc , New York , NY , USA.

Objective: In the 1-year phase 3 Selective estrogens, Menopause, And Response to Therapy-5 trial, cumulative amenorrhea rates with conjugated estrogens/bazedoxifene (CE/BZA) were similar to placebo and higher than with conjugated estrogens/medroxyprogesterone acetate (CE/MPA). This post hoc analysis reports bleeding/spotting rates in 4-week intervals (cycles) and 3-month intervals (quarters) with these therapies and the percentage of cases attributable to spotting only.

Methods: Generally healthy postmenopausal women with menopausal symptoms recorded vaginal bleeding/spotting in daily diaries while receiving CE 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1520046DOI Listing
November 2018
14 Reads

Preterm and term preeclampsia: differences in biochemical parameter and pregnancy outcomes.

Postgrad Med 2018 Nov 3;130(8):703-707. Epub 2018 Oct 3.

a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.

Objective: To analyze the similarities and differences in the clinical parameters, laboratory biomarkers, and pregnancy outcomes between preterm and term preeclampsia (PE).

Methods: Data on 185 women diagnosed with PE were collected from a Jiangsu Province Hospital from January 2017 to December 2017 and analyzed. 74 (40%) patients were diagnosed with preterm PE, of which 70 (94. Read More

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http://dx.doi.org/10.1080/00325481.2018.1527169DOI Listing
November 2018
3 Reads

Beyond the new blood pressure guidelines: the beat goes on.

Postgrad Med 2018 Nov 1;130(8):666-668. Epub 2018 Oct 1.

a Cardiovascular Medicine Division , University of Puerto Rico School of Medicine , San Juan , Puerto Rico.

The scope of hypertension (HTN) even for those involved in the field is staggering with numbers close to 60 million Americans and more than 1 billion individuals across the globe. It is the most common reason to seek medical attention and according to the World Health Organization, the number one cause of mortality in the world. Yet, we still don't know what is normal or abnormal. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1526624DOI Listing
November 2018
2 Reads

An alternative approach to solving the opioid epidemic: is there a role for non-pharmacologic analgesic therapies?

Authors:
Paul F White

Postgrad Med 2019 01 23;131(1):1-5. Epub 2018 Sep 23.

a Department of Anesthesiology & Pain Management , Cedars Sinai Medical Center , Los Angeles , CA , USA.

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https://www.tandfonline.com/doi/full/10.1080/00325481.2018.1
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http://dx.doi.org/10.1080/00325481.2018.1520589DOI Listing
January 2019
2 Reads

Emotional intelligence and leadership traits among family physicians.

Postgrad Med 2018 Sep 4;130(7):644-649. Epub 2018 Sep 4.

c Department of Family Medicine , Faculty of Medicine, Yildirim Beyazit University , Ankara , Turkey.

Objectives: High emotional intelligence and leadership traits are essential for physicians in managing their responsibilities and thus building successful interactions with patients. This study explored the relationship between emotional intelligence and leadership traits among family physicians.

Methods: Participants (2975 men, 972 women, mean = 42. Read More

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http://dx.doi.org/10.1080/00325481.2018.1515563DOI Listing
September 2018
19 Reads