13,606 results match your criteria Posterior Fossa Tumors


Improved neuropsychological outcomes following proton therapy relative to x-ray therapy for pediatric brain tumor patients.

Neuro Oncol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago IL.

Background: Survivors of pediatric brain tumors are at risk for impaired development in multiple neuropsychological domains. The purpose of this study was to compare neuropsychological outcomes of pediatric brain tumor patients who underwent x-ray radiotherapy (XRT) versus proton radiotherapy (PRT).

Methods: Pediatric patients who underwent either XRT or PRT and received post-treatment age-appropriate neuropsychological evaluation including measures of intelligence (IQ), attention, memory, visuographic skills, academic skills, and parent-reported adaptive functioning were identified. Read More

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http://dx.doi.org/10.1093/neuonc/noz070DOI Listing

Endoscopic transvestibular anatomy of the infratemporal fossa and upper parapharyngeal spaces for clinical surgery: a cadaver study.

Eur Arch Otorhinolaryngol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital, Fudan University, Fenyang Road Num83, Xuhui District, Shanghai, 200031, China.

Aims: To investigate the anatomy of the infratemporal fossa (ITF) and to discuss the practicality of endoscopic transvestibular surgery for an ITF tumor.

Methods: Five fresh cadaveric specimens (10 sides) with vascular silicone injection were prepared for endoscopic anatomy. A transvestibular vertical incision was made along the ramus of the mandible, and pivotal nerves, arteries, and muscles were exposed to sculpt the anatomic landmarks of the ITF. Read More

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http://dx.doi.org/10.1007/s00405-019-05410-yDOI Listing
April 2019
1 Read

Long-term impairment of social behavior, vocalizations and motor activity induced by bilateral lesions of the fastigial nucleus in juvenile rats.

Brain Struct Funct 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, Medical School Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

The cerebellum is increasingly recognized to be involved in limbic and cognitive-associative functioning. Cerebellar cognitive affective syndromes may result from various types of injuries. Cerebellar mutism may occur in children after resection of midline tumors in the posterior fossa, which has been thought to be related to damage to the cerebellar vermis. Read More

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http://link.springer.com/10.1007/s00429-019-01871-3
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http://dx.doi.org/10.1007/s00429-019-01871-3DOI Listing
April 2019
2 Reads

Septal floor rotational flap pedicled on ethmoidal arteries for endoscopic skull base reconstruction.

Laryngoscope 2019 Apr 7. Epub 2019 Apr 7.

Department of Otorhinolaryngology-Head & Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Object: Expanded endonasal approaches have dramatically changed how skull base surgery is performed, and nasoseptal flap (NSF) has significantly improved skull base reconstruction. However, challenges remain when the pterygopalatine artery is invaded by tumors; when it must be sacrificed to approach the lateral sphenoidal recess; when late-occurrence leak occurs in the sella after transsphenoidal surgery; and also when the leak is on the posterior wall of the frontal sinus, which is too distant for NSF to reach. This article describes a septal floor rotational flap pedicled on ethmoidal arteries for endoscopic skull base reconstruction in certain cases. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.27942
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http://dx.doi.org/10.1002/lary.27942DOI Listing
April 2019
4 Reads

Cerebellopontine angle ependymoma in a young adult: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15019

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Rationale: Cerebellopontine angle (CPA) ependymomas are atypical kind of ependymomas that characteristically occur in the pediatric age group. Therefore, finding a case of CPA ependymoma in a young male adult is not a common occurrence.

Patient Concerns: We present a case of a 28-year-old male who was involved in road traffic accident with suspected mild head injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000015019DOI Listing
April 2019
2 Reads

The Retrosigmoid Approach: Workhorse for Petroclival Meningioma Surgery.

Asian J Neurosurg 2019 Jan-Mar;14(1):188-192

Department of Neurosurgery, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Petroclival meningiomas (PCMs) are technically challenging lesions. We retrospectively analyzed our experience with retrosigmoid approach between 2009 and 2015 in 17 patients with PCM to evaluate changes in management strategy. In this study, we evaluated the possible risk factors and challenges for unfavorable clinical outcomes with retrosigmoid approach. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_192_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417359PMC
April 2019
1 Read

Lateral Semi-sitting Position: A Novel Method of Patient's Head Positioning in Suboccipital Retrosigmoid Approaches.

Asian J Neurosurg 2019 Jan-Mar;14(1):82-86

Department of Neurosurgery, J. J. Group of Hospitals and Grant Medical College, Mumbai, Maharashtra, India.

Background: The most common methods of positioning patients for suboccipital approaches are the lateral, lateral oblique, sitting, semisitting, supine with the head turn, and park bench. The literature on the positioning of patients for these approaches does not mention the use of lateral semisitting position. This position allows utilization of the benefits of both semisitting and lateral position without causing any additional morbidity to the patient. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_203_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417342PMC
April 2019
2 Reads

Dental root abnormalities in four children with PHACE syndrome.

Pediatr Dermatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, Wisconsin.

PHACE(S) syndrome is a condition characterized by posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal cleft, and supraumbilical raphe. We present four children with PHACE(S) syndrome who have absence of or severe malformation of the roots of their permanent first molars (PFMs). Root abnormalities in the children's molars were bilateral and not restricted to the segments affected by cutaneous hemangioma. Read More

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http://dx.doi.org/10.1111/pde.13818DOI Listing
April 2019
3 Reads

Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome.

Brain Tumor Pathol 2019 Mar 30. Epub 2019 Mar 30.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.

We focused on histological and immunohistochemical characteristics of ependymoma (EPN) with molecular profiles to develop more reproducible criteria of the diagnosis. Three expert neuropathologists reviewed the pathology of 130 samples from the Japan Pediatric Molecular Neuro-Oncology Group study. Confirmed cases were assessed for histology, surrogate markers, molecular subgrouping, and survival data. Read More

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http://dx.doi.org/10.1007/s10014-019-00338-xDOI Listing
March 2019
2 Reads

The Inverted Coronoid-Ramus Graft for Condylar Reconstruction.

Authors:
Leslie B Heffez

J Oral Maxillofac Surg 2019 Mar 2. Epub 2019 Mar 2.

Attending, Private Practice, Oral & Maxillofacial Surgery, Highland Park and Chicago, IL; NorthShore University Hospital; and Former Professor and Head, University of Illinois at Chicago, Chicago, IL. Electronic address:

The purpose of this article is to describe a creative, versatile technique for condylar reconstruction using autogenous mandibular bone. The technique has been used for reconstruction of small condyle and/or ramus defects (approximately 35 to 40 mm in length) typically associated with condylar hyperplasia, condylar tumors, idiopathic condylar resorption, and failed reconstruction attempts. The technique involves excision of the ipsilateral coronoid process-mandibular ramus, inverting it and rotating the segment 180° along its horizontal axis to replace the excised condyle. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.035DOI Listing

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Neuro Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. (J.-M.H., M.M., S.M.P., K.W.P. and M.K.).

Background: Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we reported CXorf67 overexpression as hallmark of PFA ependymoma and showed that CXorf67 can interact with EZH2 thereby inhibiting polycomb repressive complex 2 (PRC2), but the mechanism of action remained unclear. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz058DOI Listing
March 2019
6 Reads

Endoscopic third ventriculostomy prior to resection of posterior fossa tumors in children.

Childs Nerv Syst 2019 May 20;35(5):789-794. Epub 2019 Mar 20.

Division of Neurosurgery, Children's Hospital of Philadelphia, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Hydrocephalus is a common presenting symptom of pediatric posterior fossa tumors and often requires permanent cerebrospinal fluid diversion even after resection. Endoscopic third ventriculostomy (ETV) is a well-established treatment of obstructive hydrocephalus in children. The objective of this study is to demonstrate that ETV prior to posterior fossa tumor resection decreases the rate of postoperative ventriculoperitonal shunt (VPS) placement. Read More

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http://link.springer.com/10.1007/s00381-019-04125-z
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http://dx.doi.org/10.1007/s00381-019-04125-zDOI Listing
May 2019
5 Reads

Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):136-140

Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, SP, Brasil.

We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.136DOI Listing
February 2019
1 Read
0.915 Impact Factor

Short report on a rare presentation of temporal arachnoid cyst and lessons learned.

World Neurosurg 2019 Mar 15. Epub 2019 Mar 15.

Lagoon Hospital, Apapa, Lagos, Nigeria.

Stiff neck or nuchal rigidity is a significant clinical sign of neurologic disease. It is commonly associated with meningitis, subarachnoid hemorrhage and posterior fossa tumors. It may also occur as a result of tonsillar impaction following pressure in the infratentorial compartment from an expanding posterior fossa mass. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.230DOI Listing
March 2019
5 Reads
2.417 Impact Factor

Central nervous system ependymoma: clinical implications of the new molecular classification, treatment guidelines and controversial issues.

Clin Transl Oncol 2019 Mar 13. Epub 2019 Mar 13.

Servicio de Neurocirugía, Hospital Universitario de Burgos, Avda Islas Baleares 3, 09006, Burgos, Spain.

Ependymoma is an uncommon neuroepithelial tumor that may arise anywhere within the neuroaxis, both in children and in adults. It has been classically graded upon histopathological features, yet with limited clinical utility. Recently, DNA methylation profiling has provided a novel classification of ependymoma in nine molecular subgroups. Read More

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http://dx.doi.org/10.1007/s12094-019-02082-2DOI Listing
March 2019
1 Read

Hydrocephalus Due to Idiopathic Fourth Ventricle Outflow Obstruction.

J Craniofac Surg 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurosurgery.

The fourth ventricle outlet obstruction (FVOO) is a rare but well-established cause of obstructive tetra-ventricular hydrocephalus, characterizing with dilatation or large cerebrospinal fluid collection of the foramina of Magendie and Luschka. In children, it is usually the consequence of posterior cerebral fossa malformations; while in adult, the occlusion is rather acquired than congenital, mostly linked to an inflammatory process, intraventricular hemorrhage, head trauma, brain tumors or Arnold-Chiari malformation. However, idiopathic FVOO is extremely rare, and only 6 such cases have been reported in the English literature. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005314DOI Listing
March 2019
1 Read

Crescent durotomy for midline posterior fossa lesions.

Neurol India 2019 Jan-Feb;67(1):155-158

Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, India.

Objective: The conventional midline suboccipital craniectomy, the standard approach for posterior fossa lesions, involves ligation of the occipital sinus. Postoperative sequelae that could occur from ligation of the occipital sinus include hydrocephalus, cerebrospinal fluid (CSF) leak, and pseudomeningiocoele formation. The standard of practice of venous pathway preservation, as practiced elsewhere in the cranium, should also be attempted in the posterior fossa. Read More

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http://dx.doi.org/10.4103/0028-3886.253637DOI Listing

CT and Multimodal MR Imaging Features of Embryonal Tumors with Multilayered Rosettes in Children.

AJNR Am J Neuroradiol 2019 Apr 7;40(4):732-736. Epub 2019 Mar 7.

From the Departments of Pediatric Radiology (V.D.-R., C.-J.R., R.L., D.G., F.B., N.B.).

Background And Purpose: Embryonal tumors with multilayered rosettes, C19MC-altered, are brain tumors occurring in young children, which were clearly defined in the 2016 World Health Organization classification of central nervous system neoplasms. Our objective was to describe the multimodal imaging characteristics of this new entity.

Materials And Methods: We performed a retrospective monocentric review of embryonal brain tumors and looked for embryonal tumors with multilayered rosettes with confirmed C19MC alteration. Read More

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http://dx.doi.org/10.3174/ajnr.A6001DOI Listing

Spheno-Orbital Meningioma: Surgical Outcomes and Management of Recurrence.

World Neurosurg 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Objective: Spheno-orbital meningioma (SOM) is a rare intracranial tumor that arises at the sphenoid wing, extends into the orbit, and is associated with hyperostosis of the sphenoid bone. These tumors often invade important neurovascular structures around the orbital apex, superior orbital fissure, and cavernous sinus. Aggressive tumor removal could achieve acceptable control; however, residual tumor can regrow. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.123DOI Listing
March 2019
2 Reads

Propensity for different vascular distributions and cerebral edema of intraparenchymal brain metastases from different primary cancers.

J Neurooncol 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurosurgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose: This study seeks to ascertain whether different primary tumor types have a propensity for brain metastases (BMs) in different cerebral vascular territories and cerebral edema.

Methods: Consecutive adult patients who underwent surgical resection of a BM at a tertiary care institution between 2001 and 2011 were retrospectively reviewed. Only patients with the most common primary cancers (lung, breast, skin-melanoma, colon, and kidney) were included. Read More

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http://dx.doi.org/10.1007/s11060-019-03142-xDOI Listing

[Chondromucinous tumors involving craniocerebral slope area: a clinicopathological analysis of eight cases].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):199-203

Department of Pathology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

To investigate the histological type and clinicopathological characteristics of the craniocerebral slope tumors with chondromucinous features. Retrospective analysis was conducted to analyze chondromucinous tumors in the slope area diagnosed at Henan Provincial People's Hospital from October 2011 to June 2018. Relevant clinical and pathological data were reviewed, and immunohistochemistry was used to investigate the immunophenotype of the tumors. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.006DOI Listing
March 2019
1 Read

[Clinicopathological characteristics and prognosis of diffuse midline gliomas with histone H3K27M mutation: an analysis of 30 cases].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):192-198

Department of Pathology, Guangdong Provincial People's Hospital, Guangzhou 510080, China.

To analyze the clinicopathological characteristics and prognosis of diffuse midline glioma (DMG) with H3K27M mutation. Thirty cases of DMG were collected in Guangdong Sanjiu Brain Hospital from October 2016 to May 2018. The patients' clinicopathological data including age, tumor site and histological grade, treatment and follow-up data were collected and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.005DOI Listing
March 2019
1 Read

Transjugular transsigmoid approach for triple dumbbell-shaped jugular foramen schwannomas.

Acta Neurochir (Wien) 2019 Apr 4;161(4):739-743. Epub 2019 Mar 4.

Department of Neurosurgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: Jugular foramen tumors, particularly those that are triple dumbbell-shaped with intracranial, intraforaminal, and extracranial extensions, are difficult to access surgically. However, advances in neuroimaging, neuromonitoring, and skull base surgery have enabled their safe resection with lower rates of morbidity and mortality.

Method: We share our experience with the surgical technique for the management of triple dumbbell-shaped jugular foramen schwannomas. Read More

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http://dx.doi.org/10.1007/s00701-019-03860-1DOI Listing

Desmoid tumor after resection of cerebellar hemangioblastoma.

J Neurosurg Sci 2019 Apr;63(2):224-230

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.

Desmoid tumors are histologically benign but locally invasive tumors that rarely can occur in the head and neck. In this article, we illustrate a rare case of desmoid tumor formation in intracranial posterior fossa after suboccipital craniotomy for hemangioblastoma. A 43-year-old woman presented with headaches, dizziness, equilibrium disorders, nausea, and vomiting due to a hemangioblastoma in posterior fossa. Read More

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http://dx.doi.org/10.23736/S0390-5616.16.03398-1DOI Listing
April 2019
3 Reads
0.780 Impact Factor

Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.

J Clin Oncol 2019 Apr 27;37(12):974-983. Epub 2019 Feb 27.

22 Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: The Children's Oncology Group trial ACNS0121 estimated event-free survival (EFS) and overall survival for children with intracranial ependymoma treated with surgery, radiation therapy, and-selectively-with chemotherapy. Treatment was administered according to tumor location, histologic grade, and extent of resection. The impacts of histologic grade, focal copy number gain on chromosome 1q, and DNA methylation profiles were studied for those undergoing surgery and immediate postoperative conformal radiation therapy (CRT). Read More

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http://dx.doi.org/10.1200/JCO.18.01765DOI Listing
April 2019
1 Read
18.428 Impact Factor

Clinical Applications for Diffusion MRI and Tractography of Cranial Nerves Within the Posterior Fossa: A Systematic Review.

Front Neurosci 2019 7;13:23. Epub 2019 Feb 7.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

This paper presents a systematic review of diffusion MRI (dMRI) and tractography of cranial nerves within the posterior fossa. We assess the effectiveness of the diffusion imaging methods used and examine their clinical applications. The Pubmed, Web of Science and EMBASE databases were searched from January 1st 1997 to December 11th 2017 to identify relevant publications. Read More

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http://dx.doi.org/10.3389/fnins.2019.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380197PMC
February 2019
3 Reads

Health status, Health-Related Quality of Life and Socio-economic Outcome in Childhood Brain Tumor Survivors: a German Cohort Study.

Neuro Oncol 2019 Feb 22. Epub 2019 Feb 22.

Pediatric Hematology/Oncology, University Children's Hospital Bonn, Germany.

Background: With rising numbers of childhood cancer survivors, somatic and socio-economic outcome as well as the health-related quality of life (QoL) gain increasing relevance. Based on the first nationwide German Survey on Life Situation, State of Health and Quality of Life of Childhood Cancer Survivors, the VIVE-survey, we report the outcome of survivors of childhood brain tumors (BTS) localized in the posterior fossa.

Methods: 270 participants with a median follow-up period of 21. Read More

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http://dx.doi.org/10.1093/neuonc/noz044DOI Listing
February 2019
1 Read

Whole-tumor histogram analysis of apparent diffusion coefficient in differentiating intracranial solitary fibrous tumor/hemangiopericytoma from angiomatous meningioma.

Eur J Radiol 2019 Mar 22;112:186-191. Epub 2019 Jan 22.

Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Purpose: To assess the role of histogram analysis of apparent diffusion coefficient (ADC) maps based on whole-tumor in differentiating intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) from angiomatous meningioma (AM).

Materials And Methods: Pathologically confirmed intracranial SFT/HPC (n = 15) and AM (n = 20) were retrospectively collected and their clinical and conventional MRI features were analyzed. Diffusion-weighted (DW) images (b = 0 and 1000 s/mm) were processed with the mono-exponential model. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.023DOI Listing
March 2019
9 Reads

Compression of the middle cerebellar tract by posterior fossa tumors before and after Gamma Knife radiosurgery studied with diffusion tensor imaging.

J Radiosurg SBRT 2019 ;6(1):11-17

Centro Gamma Knife Dominicano, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.

Purpose: To investigate if clinically asymptomatic compression of the middle cerebellar tract by extracerebral posterior fossa tumors can produce changes in diffusion tensor imaging (DTI) parameters and if these changes return to normal after Gamma Knife radiosurgery (GKRS).

Material And Methods: In 22 patients (12 female, mean age 53.8 years) with posterior fossa tumors (14 schwannomas and 8 meningiomas), the middle cerebellar tract was tracked using DTI data. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355455PMC
January 2019
1 Read

Pontine tumor in a neonate: case report and analysis of the current literature.

J Neurosurg Pediatr 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Pediatric Hematology and Oncology, Goethe University; Departments of.

Tumors of the central nervous system represent the largest group of solid tumors found in pediatric patients. Pilocytic astrocytoma is the most common pediatric glioma, mostly located in the posterior fossa. The majority of brainstem tumors, however, are classified as highly aggressive diffuse intrinsic pontine gliomas (DIPGs) and their prognosis is dismal. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18215DOI Listing
February 2019
1 Read

Resection of a cerebellar hemangioblastoma via a minimally invasive tubular approach.

J Clin Neurosci 2019 May 4;63:240-243. Epub 2019 Feb 4.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Hemangioblastomas are rare benign, highly vascularized tumors occurring in the cerebellum and the spinal cord. They often develop tumor-associated cysts multiple times the size of the solid part of the tumor. Patients with von Hippel-Lindau (VHL) disease typically exhibit multiple tumors with the need of repeated surgeries during their lifetime. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.045DOI Listing
May 2019
1 Read

Intracranial endodermal cyst presenting with nonobstructive hydrocephalus: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14322

Department of Neurosurgery, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan.

Rationale: Endodermal cysts are rare benign lesions in the central nervous system. Their common symptoms include headache and neck pain caused by mass effect or inflammatory reaction. We report the case of an elderly woman with intracranial endodermal cyst who presented with nonobstructive hydrocephalus. Read More

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http://dx.doi.org/10.1097/MD.0000000000014322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380779PMC
February 2019
3 Reads

Clinical Characteristics and Prognostic Factors of Treatment in Pediatric Posterior Cranial Fossa Ependymoma.

Pediatr Neurosurg 2019 30;54(2):98-107. Epub 2019 Jan 30.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,

Objective: The purpose of this study was to explore the clinical features and risk factors of outcomes in pediatric posterior cranial fossa ependymoma. We aim to provide evidence-based recommendations for the improvement of prognoses.

Patients And Methods: The clinical data, treatment modalities, approaches performed, recurrence rates and times, as well as the outcomes of 94 cases were analyzed retrospectively. Read More

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https://www.karger.com/Article/FullText/495809
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http://dx.doi.org/10.1159/000495809DOI Listing
January 2019
6 Reads
0.497 Impact Factor

Hypothalamic-pituitary function following childhood brain tumors: Analysis of prospective annual endocrine screening.

Pediatr Blood Cancer 2019 May 28;66(5):e27631. Epub 2019 Jan 28.

Divisions of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Outcomes for childhood brain tumors are now associated with a five-year survival rate of 75%. Endocrine effects of brain tumors are common, occurring in 43% of patients by 10 years from tumor diagnosis. Optimal timing of screening for endocrinopathies remains undefined. Read More

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http://dx.doi.org/10.1002/pbc.27631DOI Listing
May 2019
1 Read

Unedited microneurosurgery of a mixed germ cell tumor of the pineal region.

Surg Neurol Int 2018 24;9:262. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Germ cell tumors comprise a heterogeneous group of neoplasms, classified as germinomas and nongerminomatous germ cell tumors based on clinicopathological features. The nongerminomatous group of tumors includes embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), choriocarcinoma, mature and immature teratoma, and mixed germ cell tumors with more than one element. While germinomas are radiation-sensitive tumors, all other tumors have less response to radiotherapy, and it is suggested that gross total resection improves their overall survival and tumor-free survival rates. Read More

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http://dx.doi.org/10.4103/sni.sni_357_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322164PMC
December 2018
2 Reads

Fluorescein sodium-guided resection of a cerebellar lymphoma: case report and literature review.

Br J Neurosurg 2019 Jan 25:1-4. Epub 2019 Jan 25.

a Department of Neurosurgery , Galeazzi Research and Clinical Hospital , Milan , Italy.

We report on a patient, who underwent the resection of a cerebellar primary central nervous system lymphoma and was administered intraoperative fluorescein sodium to improve the visualization of the tumor and guide surgery. Low-dosage fluorescein was administered prior to opening the dura so to distinguish contrast-enhanced lymphomatous tissue from the surrounding unenhanced brain cerebellar parenchyma. Intraoperatively, the tumor was indistinguishable from cerebellar parenchyma under the white light, however, after the administration of low-dose intravenous fluorescein, it appeared brightly fluorescent under yellow light, and was safely resected. Read More

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http://dx.doi.org/10.1080/02688697.2018.1556779DOI Listing
January 2019

Analysis of survival in patients with brain metastases treated surgically: Impact of age, gender, oncologic status, chemotherapy, radiotherapy, number and localization of lesions, and primary cancer site.

Rev Assoc Med Bras (1992) 2018 Aug;64(8):717-722

. Neurosurgery Service of the Public Servant's Hospital of the State of São Paulo (HSPE-SP), São Paulo/SP, Brasil.

Objective: To evaluate the survival of patients with brain metastases treated surgically according to the potentially involved factors.

Methods: 71 patients treated surgically were analyzed with the diagnosis of brain metastases during the period from January 2011 to November 2014, totaling 47 months of follow-up. The Kaplan-Meier curve method was used for survival analysis. Read More

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http://dx.doi.org/10.1590/1806-9282.64.08.717DOI Listing
August 2018
2 Reads

Visual Complications of Pediatric Posterior Fossa Tumors: Analysis of Outcomes.

Pediatr Neurol 2019 Mar 18;92:48-54. Epub 2018 Oct 18.

Department of Ophthalmology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas. Electronic address:

Objective: Visual abnormalities are common among children with posterior fossa tumors, resulting from disruption of ocular afferent and efferent systems due to the tumor or surgery. This study describes the visual complications and outcomes associated with these tumors.

Methods: Clinical and radiographic data of patients who underwent index surgery for resection of posterior fossa tumor from 2007 to 2016 were reviewed. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.09.016DOI Listing
March 2019
3 Reads

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature.

World J Surg Oncol 2019 Jan 19;17(1):22. Epub 2019 Jan 19.

Division of Neurological Surgery, Department of Surgery, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

Background: Congenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis. Read More

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http://dx.doi.org/10.1186/s12957-019-1564-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339688PMC
January 2019
5 Reads
1.200 Impact Factor

Cerebellar mutism after posterior fossa tumor resection in children: a multicenter international retrospective study to determine possible modifiable factors.

Childs Nerv Syst 2019 Jan 18. Epub 2019 Jan 18.

Division of Neurosurgery, Department of Surgery, British Columbia Children's Hospital and University of British Columbia, Vancouver, Canada.

Purpose: A preliminary survey of pediatric neurosurgeons working at different centers around the world suggested differences in clinical practice resulting in variation in the risk of pediatric cerebellar mutism (CM) and cerebellar mutism syndrome (CMS) after posterior fossa (PF) tumor resection. The purposes of this study were (1) to determine the incidence and severity of CM and CMS after midline PF tumor resection in children treated at these centers and (2) to identify potentially modifiable factors related to surgical management (rather than tumor biology) that correlate with the incidence of CM/CMS.

Methods: Attending pediatric neurosurgeons at British Columbia's Children's Hospital (BCCH) and neurosurgeons who completed a pediatric neurosurgery fellowship at BCCH were invited to provide data from the center where they currently practiced. Read More

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http://dx.doi.org/10.1007/s00381-019-04058-7DOI Listing
January 2019
5 Reads

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Nat Commun 2019 01 18;10(1):332. Epub 2019 Jan 18.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will benefit from them remains a major clinical challenge. Here we show that medulloblastomas driven by the transcription factor Gfi1 are exquisitely dependent on the enzyme lysine demethylase 1 (Kdm1a/Lsd1). We demonstrate that Lsd1 physically associates with Gfi1, and that these proteins cooperate to inhibit genes involved in neuronal commitment and differentiation. Read More

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http://www.nature.com/articles/s41467-018-08269-5
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http://dx.doi.org/10.1038/s41467-018-08269-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338772PMC
January 2019
10 Reads

Contralateral facial nerve paresis subsequent to posterior fossa meningioma surgery in a child: case report.

Childs Nerv Syst 2019 May 15;35(5):897-898. Epub 2019 Jan 15.

Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Gharib Street, Tehran, 141557854, Iran.

Introduction: Meningiomas are relatively uncommon neoplasms in the pediatric population and posterior fossa is a very rare location for these tumors. Only a few cases of contralateral cranial nerve deficits have been reported but no cases of pediatric meningioma with contralateral facial nerve paresis have been documented in literature.

Cerebellopontine Angle Meningioma Who Case Report: We present a 4 year old girl with found postoperative contralateral facial nerve paresis. Read More

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http://link.springer.com/10.1007/s00381-019-04053-y
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http://dx.doi.org/10.1007/s00381-019-04053-yDOI Listing
May 2019
8 Reads

Pediatric intracranial lower cranial nerve schwannoma unassociated with neurofibromatosis type 2: case report and review of the literature.

Childs Nerv Syst 2019 Jan 13. Epub 2019 Jan 13.

Division of Neurosurgery, National Center for Child Health and Development, Okura 2-10-1, Setagaya-ku, Tokyo, 157-8535, Japan.

Introduction: Pediatric schwannomas are rare, and most of them are associated with neurofibromatosis type 2 (NF2) and usually located in the vestibular nerve. Herein, we present the first pediatric case of intracranial schwannoma derived from the IX/X nerve complex unrelated to NF2.

Case Report: The patient was a 9-year-old boy who presented with a 3-month history of headache and nausea. Read More

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http://dx.doi.org/10.1007/s00381-018-04045-4DOI Listing
January 2019
2 Reads

[Brain tumors in children: about 136 cases].

Pan Afr Med J 2018 24;30:291. Epub 2018 Aug 24.

Service d'Anatomie Pathologique, CHU Mohammed VI, Hôpital Arrazi, Marrakech, Maroc.

Brain tumors are the most diagnosed solid tumors in children under the age of 15 years worldwide. However, the epidemiological and anatomopathological profile of these tumors has been poorly described in African and, particularly, in Moroccan literature. This study highlights the epidemiological and anatomopathological peculiarities of primary brain tumors in children living in the region of Marrakech (south Morocco). Read More

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http://www.panafrican-med-journal.com/content/article/30/291
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http://dx.doi.org/10.11604/pamj.2018.30.291.13208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317398PMC
January 2019
8 Reads

Prone versus sitting position in pediatric low-grade posterior fossa tumors.

Childs Nerv Syst 2019 Mar 4;35(3):421-428. Epub 2019 Jan 4.

Academic Neurosurgery, Department of Neurosciences, University of Padova Medical School, via Giustiniani 5, 35100, Padova, Italy.

Purpose: The choice between sitting and prone position to access the infratentorial space in a suboccipital craniotomy is still a matter of debate. The comparisons in terms of complications and outcome of both positions are scarce, and the pediatric population is indeed more infrequent in these in scientific reviews. In this paper, we assess intraoperative and postoperative complications and neurological outcome in pediatric patients undergoing posterior cranial fossa surgery for pilocytic astrocytoma in sitting and prone position respectively. Read More

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http://link.springer.com/10.1007/s00381-018-04031-w
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http://dx.doi.org/10.1007/s00381-018-04031-wDOI Listing
March 2019
4 Reads

Radiation-Induced Moyamoya Syndrome After Proton Therapy in Child with Clival Chordoma: Natural History and Surgical Treatment.

World Neurosurg 2019 Mar 22;123:306-309. Epub 2018 Dec 22.

Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, Genoa, Italy.

Background: Proton therapy has proven to be effective and safe in the treatment of radioresistant skull base tumors such as chordomas. Thanks to the peculiar physical properties of the proton beam, radiation energy is delivered in a narrow space called the Bragg peak and the surrounding normal tissues receive a minimal amount of the radiation dose. This is important to lower the risk of radiation-induced damage, especially in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183287
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http://dx.doi.org/10.1016/j.wneu.2018.12.048DOI Listing
March 2019
26 Reads

Meningiomas Originated at the Falcotentorial Region: Analysis of Topographic and Diagnostic Features Guiding an Optimal Surgical Planning.

World Neurosurg 2019 Mar 21;123:e723-e733. Epub 2018 Dec 21.

Department of Neurosurgery, Department of Surgery, University Hospital La Princesa, Madrid, Spain.

Background: Meningiomas arising at the pineal region are a rare entity and still represent a great neurosurgical challenge given their deep location and critical neuroanatomic relationships. The optimal surgical approach to treat these lesions is still under debate. Our objective is to review the topographic and diagnostic features of these lesions, which can help to guide an optimal surgical outcome. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.013DOI Listing
March 2019
2 Reads

Solitary Primary Central Nervous System Lymphoma Mimicking Third Ventricular Colloid Cyst-Case Report and Review of Literature.

World Neurosurg 2019 Mar 19;123:286-294. Epub 2018 Dec 19.

Hamad Medical Corporate, Neurosurgery, Doha, Qatar.

Background: Primary central nervous system lymphoma is a rare malignant tumor of the central nervous system. It is associated with poor prognosis and accounts for 0.7%-0. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.026DOI Listing
March 2019
2 Reads

Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery.

Authors:
Sibel Aksoy

Indian J Ophthalmol 2019 Jan;67(1):145-147

Department of Ophthalmology, Saglik Bilimleri University, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

In this report, we report the case of a 7-year-old boy with corneal neovascularization due to exposure keratopathy following cerebellar astrocytoma surgery. Corneal surface healing was achieved with topical treatment and therapeutic contact lens, after which topical steroid was administered for stromal haze and corneal neovascularization. After 2 months of steroid therapy failed, corneal neovascularization responded well to topical aflibercept administration, showing complete regression. Read More

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http://dx.doi.org/10.4103/ijo.IJO_418_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324144PMC
January 2019
1 Read

Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis.

Eur Radiol 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, Institut de Diagnòstic per la Imatge (IDI), Centre Bellvitge, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

Objectives: Assessing a posterior fossa tumour in an adult can be challenging. Metastasis, haemangioblastoma, ependymal tumours, and medulloblastoma are the most common diagnostic possibilities. Our aim was to evaluate the contribution of magnetic resonance spectroscopy (MRS) in the diagnosis of these entities. Read More

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http://dx.doi.org/10.1007/s00330-018-5879-zDOI Listing
December 2018
3 Reads