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Jpn J Clin Oncol 2019 May;49(5):452-457

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

Objective: We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer.

Methods: The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histopathological paratracheal lymph node metastasis and thyroid invasion, and recurrence around the paratracheal area for 184 patients who underwent initial surgery among 280 participants. Read More

J Gastroenterol Hepatol 2019 Aug 21;34(8):1384-1389. Epub 2019 Jan 21.

Second Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Background And Aim: Simultaneous and metachronous head and neck cancers are likely to develop in patients with current or previous esophageal cancer. The Valsalva maneuver facilitates the visualization of the hypopharyngeal area during endoscopic observation, but it requires transnasal endoscopy. We developed a novel Valsalva maneuver using transoral endoscopy with a lip cover-type mouthpiece. Read More

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):123-129

Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Purpose Of Review: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.

Recent Findings: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;53(5):346-351

Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

To investigate the key factors influencing the prognosis of hypopharyngeal carcinoma and the therapeutic methods improving the efficacy of treatments for hypopharyngeal carcinoma. Two hundred and sixty-four cases of hypopharyngeal squamous cell carcinoma treated from May 2010 to May 2015 were analyzed retrospectively. There were 211 cases of pyriform sinus carcinoma, 37 cases of posterior pharyngeal wall carcinoma, and 16 cases of postcricoid carcinoma. Read More

Dig Endosc 2018 Jul 26;30(4):516-521. Epub 2018 Apr 26.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Transoral endoscopy with narrow band imaging (NBI) is useful for early detection of head and neck (HN) cancer. However, the lateral and anterior walls of the oropharynx, postcricoid area, and posterior wall of the hypopharynx are difficult to observe using transoral endoscopy. Advanced cancers in these regions may be missed even when NBI is used. Read More

Medicine (Baltimore) 2017 Nov;96(44):e8500

aDepartment of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University bDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University cDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University dDepartment of Diagnostic Ultrasound, Beijing Aerospace General Hospital, Beijing, China.

Rationale: Infantile desmoid fibromatosis of the postcricoid area is a rare disease and is characterized by a proliferation of fibrous tissue with non-metastasis, local infiltration, and a high rate of recurrence after surgical resection. Currently, ultrasound is scarcely used in the hypopharynx and larynx area.

Patient Concerns: A 4-year-old boy presented with hoarseness, deep voice and snoring for 2∼4 years without any surgical history. Read More

BMJ Case Rep 2017 Jun 19;2017. Epub 2017 Jun 19.

ENT Department, Dubai Health Authority-Dubai Hospital, Dubai, United Arab Emirates.

We present a case of large mass arising from the right pyriform sinus extending inferiorly to the postcricoid area and superiorly to the right aryepiglottic fold causing a foreign body sensation and obstructive symptoms, its histological examination following the endoscopic surgical excision showed a lipoma. We are also describing the endoscopic, radiological and intraoperative findings with a brief literature review. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Dec;30(24):1913-1917

Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.

To describe the therapeutic effect of transoral endoscopic minimally invasive surgery for hypopharyngeal postcricoidarea and upper esophageal lesions. Transoral endoscopic minimally invastive surgery was carried out in fifteen patients.There were 7 patients with primary tumors on the postcricoid area, including three squamous cell carcinoma（2 cases T2N0M0，1 case T2N2cM0），two cavernous hemangioma, one giant fibrovascular polyp and one recurrent lipofibroma. Read More

Clin Exp Otorhinolaryngol 2016 Sep 21;9(3):185-91. Epub 2016 Jul 21.

Department of ENT, Kunming City Children's Hospital, Kunming, China.

Objectives: The aim of this study was to investigate the feasibility and safety of percutaneous (125)I seed permanent implantation for advanced hypopharyngeal carcinoma from toxicity, tumor response, and short-term outcome.

Methods: (125)I seeds implant procedures were performed under computed tomography for 34 patients with advanced hypopharyngeal carcinoma. We observed the local control rate, overall survival, and acute or late toxicity rate. Read More

Auris Nasus Larynx 2017 Feb 2;44(1):122-125. Epub 2016 Jun 2.

Division of Radiation Oncology, Isesaki Municipal Hospital, Isesaki, Gunma, Japan.

Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Read More

J Voice 2017 Jan 18;31(1):129.e15-129.e18. Epub 2016 Jan 18.

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.. Electronic address:

Objectives: The aim of this study was to clarify the nature of laryngeal schwannomas through review of the experience of a single institution during a 104-year period.

Study Design: This is a retrospective case series.

Methods: The Mayo Clinic, Rochester, Minnesota clinical and surgical pathology database was reviewed for the years 1985-2011. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Apr;29(7):597-600

Objective: By studying the MRI apperances of postcricoid area invaded by laryngeal carcinoma, to identify the characteristic appearances of the invaded postcricoid area and to provide information on the early detection of the lesions.

Method: Eighteen cases of MRI images of postcricoid area invaded by laryngeal carcinoma were included in this study. To find out the characteristic manifestation of the lesions, the destructions of surrounding structures and layers, and the invaded extent were observed. Read More

Ear Nose Throat J 2014 Oct-Nov;93(10-11):E32-7

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, 325 Cheng-Kung Rd., Section 2, Taipei 114, Taiwan, Republic of China.

We report a unique case of synchronous double hypopharyngeal tumors in a 39-year-old man. The patient presented with a 1-year history of a muffled voice and mild odynophagia. Laryngoscopy detected two grossly different tumors in the hypopharynx: a malignant fibrous histiocytoma (MFH) in the postcricoid area and a squamous cell carcinoma (SCC) in the posterior pharyngeal wall. Read More

Laryngoscope 2015 Feb 23;125(2):356-9. Epub 2014 Jul 23.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.

Introduction: Postcricoid carcinoma in India, is seen especially in middle-aged females. Surgical treatment for postcricoid carcinoma has reduced because of increased organ-preserving nonsurgical strategies. Surgical intervention leads to morbidity in the form of laryngectomy. Read More

PLoS One 2013 11;8(11):e78718. Epub 2013 Nov 11.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: High-risk human papillomavirus (HPV) is an oncogenic virus that causes oropharyngeal cancers, and it has a favorable outcome after the treatment. Unlike in oropharyngeal cancer, the prevalence and role of high-risk HPV in the etiology of hypopharyngeal squamous cell carcinoma (HPSCC) is uncertain.

Objective: The aim of the present study was to evaluate the effect and prognostic significance of high-risk HPV in patients with HPSCC. Read More

Ear Nose Throat J 2012 May;91(5):204-5

Department of Otolaryngology-Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Laryngeal schwannomas (neurilemmomas) are extremely rare, and they present the otorhinolaryngologist with diagnostic and management challenges. These lesions usually present as a submucosal mass, and they are always a potential threat to the airway. We describe the case of a 75-year-old woman with a laryngeal schwannoma that arose from the left postcricoid area and covered the piriform sinus and arytenoid cartilage on that side. Read More

Laryngorhinootologie 2012 Mar 28;91 Suppl 1:S63-85. Epub 2012 Mar 28.

Universitäts-HNO-Klinik, Universitätsmedizin Mannheim, Mannheim.

The treatment of laryngeal and hypopharyngeal malignancies remains a challenging task for the head and neck surgeon as the chosen treatment modality often has to bridge the gap between oncologically sound radicality and preservation of function. Due to the increase in transoral laser surgery in early tumor stages and chemoradiation in advanced stages, the usage of traditional transcutaneous approaches has decreased over the recent past. In addition, the need for a function-sparing surgical approach as well as highest possible quality of life has become evident. Read More

Laryngoscope 2011 Feb 13;121(2):397-403. Epub 2011 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, University of Connecticut, Farmington, Connecticut, USA.

Objectives/hypothesis: Postcricoid vascular lesions are a rare cause of dysphagia and stridor in the pediatric population. Currently, there is no clear consensus on what type of vascular lesions are common in the postcricoid area because adequate histological or immunohistochemistry studies are lacking. This study aimed to describe the histology and immunohistochemistry of postcricoid masses in our institutions' experience, and consolidate available data on the symptoms, management, and histology of these unusual malformations with a comprehensive literature review. Read More

Kulak Burun Bogaz Ihtis Derg 2010 Nov-Dec;20(6):314-7

Department of Otolaryngology, Medicine Faculty of Ankara University, Ankara, Turkey.

Hemangiomas are the most common vascular tumors mostly (60%) seen in the head-neck region. Head-neck hemangiomas are seen frequently in the oral cavity, rarely in the larynx. Adult laryngeal hemangiomas are rare and often seen in the supraglottic region, therefore causing dysphagia/dysphonia. Read More

Harefuah 2010 Feb;149(2):77-9, 125

Pediatric Otolaryngology Unit, Department of Otolaryngology Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

A 7-months-old female presented with coughing spells while feeding. Flexible laryngoscopy revealed a round bluish mass, emanating from the postcricoid area when the child cried or strained and disappeared when she relaxed. She was treated with systemic steroids for a month and was doing well. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009 Sep;44(9):710-5

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, Jinan, China.

Objective: To review the experience of different surgical construction methods and comprehensive treatments for hypopharyngeal cancer.

Methods: Three hundred and fifty-two cases (According to UICC 2002 criteria, stage I, 3; II, 31; III, 134; IV, 184) with hypopharyngeal cancer were retrospectively reviewed from 1999 to 2005 in the Department of Otorhinolaryngology of Qilu Hospital of Shandong University, including 321 males and 31 females. The median age was 58 years old, ranged from 26 to 82 years old. Read More

Dis Esophagus 2009 ;22(4):E1-5

GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

The inlet patch is an area of heterotopic gastric mucosa most commonly located in the postcricoid portion of the esophagus at, or just below, the level of the upper esophageal sphincter. Esophageal and supraesophageal symptoms are commonly associated with inlet patch, while esophageal adenocarcinoma rarely complicates it. Laryngeal adenocarcinoma associated with inlet patch is not described in the literature. Read More

Auris Nasus Larynx 2008 Jun 6;35(2):304-7. Epub 2008 Feb 6.

Department of Otolaryngology, Head and Neck Surgery, Saitama Medical University, Morohongo 38, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan.

Cases of leiomyosarcoma in the head and neck are very rare with only four reports of a leiomyosarcoma originating in the hypopharynx. A rare case of leiomyosarcoma of the hypopharynx is described. A 62-year-old woman, who had experienced slight difficulty of swallowing and hoarseness, visited our hospital. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006 Dec;20(12):1183-5

Department of Head and Neck Surgery, Cancer Hospital of Nantong, Nantong Jiangsu, 226361, PR China.

Objective: To study the feasibility, surgical techniques, and results of submental island flaps for reconstruction of hypopharyngeal non-circumferential defects.

Methods: A retrospective review of the archives was performed on 16 patients (6 males, 10 females, aged 41-78 years) who suffered from hypopharyngeal cancer. From August 1998 to August 2002, the patients underwent a partial removal of the hypopharynx and reconstruction by submental island flaps. Read More

Int J Pediatr Otorhinolaryngol 2007 Jan 22;71(1):147-51. Epub 2006 Aug 22.

Otolaryngology Department, Hopital E. Herriot, Place d'Arsonval, 69003 Lyon, France.

To discuss management of postcricoid and upper esophageal hemangiomas in infants. Four children presenting with progressive feeding and/or respiratory disturbance underwent endoscopy including systematic esophagoscopy revealing the hemangioma of the postcricoid area and extending to the lumen of the upper esophagus. In the three children with severe disturbance, systemic steroids were insufficient and open surgical excision brought the hemangioma under control. Read More

Ai Zheng 2005 Nov;24(11):1372-5

Department of Otolhryngology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, PR China.

Background & Objective: The prolongation of life expectancy results in an increasing number of aged patients with hypopharyngeal carcinoma who have poor surgical tolerance because of degenerative organ functions. This study was to explore the surgical methods and preservation of laryngeal function for aged patients with hypopharyngeal carcinoma.

Methods: Clinical data of 84 patients with hypopharyngeal carcinoma who aged above 60 years, treated from 1996 to 2001, were retrospectively reviewed. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005 Sep;40(9):691-5

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China.

Objective: To review the experience of different surgical construction methods for hypopharyngeal cancer with cervical esophageal invasion.

Methods: From 1989 to 2000,forty-eight patients with advanced hypopharyngeal cancer and cervical esophageal invasion were retrospectively reviewed, including 38 males and 10 females. The median age was 54. Read More

Zhonghua Zhong Liu Za Zhi 2005 Jan;27(1):48-51

Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.

Objective: To present the treatment results and to identify the most effective therapeutic plan of different therapeutic modalities in patients with squamous-cell carcinoma of hypopharynnx.

Methods: A retrospective review of 464 patients with squamous-cell carcinoma of the hypopharynx treated between 1958 and 1998 was accomplished. The clinical characteristics, results of different treatments were analyzed by SPSS 10. Read More

Radiat Med 2004 Jan-Feb;22(1):30-6

Department of Radiology, Osaka National Hospital, Osaka 540-0006, Japan.

Purpose: We have been treating posterior pharyngeal wall cancer of the oropharynx and hypopharynx with external radiotherapy according to our policy reported in the 1970s.

Materials And Methods: Between 1968 and 1995, 51 patients were treated. Treatment policy was decided on the basis of the treatment response after 40 Gy of radiotherapy. Read More

Laryngoscope 2003 Sep;113(9):1595-9

Department of Otolaryngology--Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

Objectives/hypothesis: The presence of nodal metastatic disease in head and neck cancer is the foremost prognostic factor. Although neck dissection is the surgical gold standard for the treatment of cervical lymphatic spread, the paratracheal nodal group is not routinely included in the dissection. The study determined the nodal yield, presence of metastases, and prognostic importance of paratracheal nodes in patients with advanced carcinoma of the upper aerodigestive tract. Read More

Laryngoscope 2002 May;112(5):834-8

Department of Otorhinolaryngology, Head and Neck Surgery, Odense University Hospital, Denmark.

Objectives: The purpose of this study is to present the treatment results and to identify possible prognostic indicators in patients with hypopharyngeal squamous cell carcinoma (HPC).

Study Design: A consecutively admitted series of 110 patients was analyzed retrospectively. The female male ratio was 29: 81. Read More

Head Neck 2000 Aug;22(5):524-9

Department of Otolaryngology, University of Brescia, Italy.

Background: Granular cell tumor (GCT), or Abrikossoff's tumor, is an unusual lesion probably arising from Schwann cells. It is frequently found in the head and neck region, where the tongue is the most commonly affected site. Involvement of the hypopharynx is exceedingly rare because, to the best of our knowledge, only four cases have been reported in the literature. Read More

Bull Cancer Radiother 1996 ;83(2):115-7

Institut Gustave-Roussy, Villejuif, France.

The aim of this prospective study was to decrease the rate of locoregional recurrence (LRR) and distant metastasis (DM) with a multi-modality approach in hypopharyngeal squamous cell carcinoma (HSCC). Patients presenting with squamous cell carcinoma of the pyriform sinus, epilarynx or postcricoid area with indication of pharyngolaryngectomy, without previous treatment, distant metastasis, multiple primaries or general contraindications for surgery and chemotherapy were included in the study. Patients received three consecutive cycles of chemotherapy (CDDP cisplatinium 100 mg/m2 D1, 5-FU 1 g/m2 D1 to D5) before surgery, then two postoperative courses of the same chemotherapy at day 10 and 31 after surgery. Read More

J Laryngol Otol 1995 Aug;109(8):737-40

Department of Otolaryngology, College of Medicine, Assuit University, Egypt.

Three hundred and seventeen patients with hypopharyngeal tumours presented at Assuit University Hospital and were studied retrospectively with regard to sex and age incidence. Postcricoid tumours form the majority (50.1 per cent) followed by pyriform fossa tumours (26. Read More

Otolaryngol Pol 1993 ;47(4):311-4

Kliniki Otolaryngologii Instytutu Chirurgii AM, Warszawie.

Squamous cell carcinoma arising in the postcricoid area of the hypopharynx is relatively late diagnose. Previous observation concerning patients treated in our Clinic and the data from literature confirmed very bad diagnosis in this cases. The results of the Clinical observation of 58 patients and pathomorphology findings in 35 preparates have been described. Read More

Indian J Cancer 1991 Sep;28(3):131-8

Department and Otolaryngolory, All India Institute of Medical & Sciences, New Delhi.

Hypopharyngeal carcinoma is an aggressive cancer with a guarded prognosis. Results of 64 patients with-hypopharyngeal cancer, 59 of whom were in stage III or IV, undergoing curative therapy during a six-year period were analysed. A combined modality resulted in a 62% and 38. Read More

Head Neck Surg 1987 Sep-Oct;10(1):14-8

ENT and Head & Neck Oncology Department, Centre Oscar Lambret, Lille, France.

Hypopharynx (HC: pyriform fossa, postcricoïd area, and posterior wall) and lateral epilarynx carcinomas (LEC: aryepiglottic fold, pharyngoepiglottic fold, and arytenoïd) have a high tendency to cervical lymph node invasion. Such nodal extension is a well-known prognostic factor. This study is based on a retrospective review of 884 clinical records of previously untreated HC or LEC. Read More

J Laryngol Otol 1987 Jun;101(6):589-91

In performing total laryngectomy for carcinoma of the larynx, the pharynx should be entered at sites away from the tumour. When the tumour is supraglottic in location, the entry should be through the lateral pharyngeal wall; and when the tumour is located in the postcricoid area, entry above the hyoid bone is preferred. Read More

J Laryngol Otol 1986 Jan;100(1):85-95

Twenty-one total pharyngo-laryngectomies have been performed at the Manchester Royal Infirmary between 1968 and 1982. A variety of methods of repair have been used, gastric transposition being the most common. Seventeen patients had received previous radiotherapy to the area, fourteen radical, two palliative and one to a supraglottic carcinoma 12 years before. Read More

Arch Otolaryngol 1984 May;110(5):323-6

Total laryngopharyngectomy has been the standard surgical treatment for postcricoid and cervical esophageal cancer. Of patients undergoing standard laryngectomy, 30% will develop esophageal speech and a substantial number of the remainder can be rehabilitated by use of the electrolarynx or tracheoesophageal puncture. However, the vast majority of patients who undergo laryngopharyngectomy with current methods of reconstruction remain voiceless. Read More

Head Neck Surg 1983 May-Jun;5(5):410-24

Thirty total laryngectomy and five pharyngolaryngoesophagectomy specimens were studied with the whole-organ sectioning technique. The horizontal plane of sectioning was chosen to study the pattern and degree of extralaryngeal spread in carcinoma of the larynx. There were 22 transglottic, 6 supraglottic, and 7 infraglottic tumors. Read More

Strahlentherapie 1980 May;156(5):315-7

Thirty-five patients with carcinoma of hypopharynx were treated with irradiation to a dosage of 5000 to 6600 rad in six to nine weeks. The one-year survival was 20 out of 35 (57%), the three-year survival five out of 24 (21%), and the five-year survival four out of 19 (21%). Patients with smaller tumours of T1N0 and T2N0 presented a higher five-year figure, three out of seven, than patients with advanced tumours, one out of twelve (8%). Read More

Head Neck Surg 1979 Nov-Dec;2(2):107-11

In a review of 80 patients with hypopharyngeal squamous-cell carcinoma, 43 patients were found to have had lesions arising in the pyriform sinus, 34 had lesions arising on the postcollateral wall of the hypopharynx, and 3 had lesions in the postcricoid area. Therapeutic modalities included radical radiation therapy in 56 patients, radiation plus surgery in 13 patients, and planned combined therapy in 11 patients. The five-year determinate survival rate of all the patients was 20%. Read More

Clin Otolaryngol Allied Sci 1976 ;1(2):137-42

A study has been carried out of 42 episodes of cardiac arrest related to 90 000 otorhinolaryngological operations. The basic pathology, factors precipitating the arrest, and the results of treatment are analysed. Clinical areas presenting special problems are the surgery of cancer of the postcricoid area, deliberate hypotension, anaesthesia for laryngoscopy and respiratory obstruction. Read More

Cancer Res 1975 Nov;35(11 Pt. 2):3308-16

Sideropenic anemia with epithelial lesions (Plummer-Vinson syndrome) was previously very common among women in northern Sweden. The incidence of this condition is decreasing, however, because of better nutrition and improved health care. Plummer-Vinson syndrome as a sequela of previous sideropenic anemia still influences the pattern of hypopharyngeal and oral cancer in northern Sweden where the female/male ratio in these diseases is remarkably high and where cancer in the postcricoid part of the hypopharynx is relatively common. Read More

Am J Surg 1971 Oct;122(4):482-6