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Esophagus 2020 07 18;17(3):323-329. Epub 2020 Feb 18.

Department of Gastroenterology, Toranomon hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, Japan.

Background: Metachronous cancer rate in the pharynx is high before and after the treatment of esophageal cancer. Endoscopic observation is difficult in the pharynx especially in the postcricoid area. Pharyngeal cancer in the postcricoid area has been often found in advanced stage. Read More

Jpn J Clin Oncol 2019 May;49(5):452-457

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

Objective: We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer.

Methods: The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histopathological paratracheal lymph node metastasis and thyroid invasion, and recurrence around the paratracheal area for 184 patients who underwent initial surgery among 280 participants. Read More

J Gastroenterol Hepatol 2019 Aug 21;34(8):1384-1389. Epub 2019 Jan 21.

Second Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Background And Aim: Simultaneous and metachronous head and neck cancers are likely to develop in patients with current or previous esophageal cancer. The Valsalva maneuver facilitates the visualization of the hypopharyngeal area during endoscopic observation, but it requires transnasal endoscopy. We developed a novel Valsalva maneuver using transoral endoscopy with a lip cover-type mouthpiece. Read More

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):123-129

Department of Otolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Purpose Of Review: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.

Recent Findings: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;53(5):346-351

Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

To investigate the key factors influencing the prognosis of hypopharyngeal carcinoma and the therapeutic methods improving the efficacy of treatments for hypopharyngeal carcinoma. Two hundred and sixty-four cases of hypopharyngeal squamous cell carcinoma treated from May 2010 to May 2015 were analyzed retrospectively. There were 211 cases of pyriform sinus carcinoma, 37 cases of posterior pharyngeal wall carcinoma, and 16 cases of postcricoid carcinoma. Read More

Dig Endosc 2018 Jul 26;30(4):516-521. Epub 2018 Apr 26.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Transoral endoscopy with narrow band imaging (NBI) is useful for early detection of head and neck (HN) cancer. However, the lateral and anterior walls of the oropharynx, postcricoid area, and posterior wall of the hypopharynx are difficult to observe using transoral endoscopy. Advanced cancers in these regions may be missed even when NBI is used. Read More

Medicine (Baltimore) 2017 Nov;96(44):e8500

Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University Department of Pathology, Beijing Tongren Hospital, Capital Medical University Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University Department of Diagnostic Ultrasound, Beijing Aerospace General Hospital, Beijing, China.

Rationale: Infantile desmoid fibromatosis of the postcricoid area is a rare disease and is characterized by a proliferation of fibrous tissue with non-metastasis, local infiltration, and a high rate of recurrence after surgical resection. Currently, ultrasound is scarcely used in the hypopharynx and larynx area.

Patient Concerns: A 4-year-old boy presented with hoarseness, deep voice and snoring for 2∼4 years without any surgical history. Read More

BMJ Case Rep 2017 Jun 19;2017. Epub 2017 Jun 19.

ENT Department, Dubai Health Authority-Dubai Hospital, Dubai, United Arab Emirates.

We present a case of large mass arising from the right pyriform sinus extending inferiorly to the postcricoid area and superiorly to the right aryepiglottic fold causing a foreign body sensation and obstructive symptoms, its histological examination following the endoscopic surgical excision showed a lipoma. We are also describing the endoscopic, radiological and intraoperative findings with a brief literature review. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016 Dec;30(24):1913-1917

Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.

To describe the therapeutic effect of transoral endoscopic minimally invasive surgery for hypopharyngeal postcricoidarea and upper esophageal lesions. Transoral endoscopic minimally invastive surgery was carried out in fifteen patients.There were 7 patients with primary tumors on the postcricoid area, including three squamous cell carcinoma（2 cases T2N0M0，1 case T2N2cM0），two cavernous hemangioma, one giant fibrovascular polyp and one recurrent lipofibroma. Read More

Clin Exp Otorhinolaryngol 2016 Sep 21;9(3):185-91. Epub 2016 Jul 21.

Department of ENT, Kunming City Children's Hospital, Kunming, China.

Objectives: The aim of this study was to investigate the feasibility and safety of percutaneous (125)I seed permanent implantation for advanced hypopharyngeal carcinoma from toxicity, tumor response, and short-term outcome.

Methods: (125)I seeds implant procedures were performed under computed tomography for 34 patients with advanced hypopharyngeal carcinoma. We observed the local control rate, overall survival, and acute or late toxicity rate. Read More

Auris Nasus Larynx 2017 Feb 2;44(1):122-125. Epub 2016 Jun 2.

Division of Radiation Oncology, Isesaki Municipal Hospital, Isesaki, Gunma, Japan.

Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Read More

J Voice 2017 Jan 18;31(1):129.e15-129.e18. Epub 2016 Jan 18.

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.. Electronic address:

Objectives: The aim of this study was to clarify the nature of laryngeal schwannomas through review of the experience of a single institution during a 104-year period.

Study Design: This is a retrospective case series.

Methods: The Mayo Clinic, Rochester, Minnesota clinical and surgical pathology database was reviewed for the years 1985-2011. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Apr;29(7):597-600

Objective: By studying the MRI apperances of postcricoid area invaded by laryngeal carcinoma, to identify the characteristic appearances of the invaded postcricoid area and to provide information on the early detection of the lesions.

Method: Eighteen cases of MRI images of postcricoid area invaded by laryngeal carcinoma were included in this study. To find out the characteristic manifestation of the lesions, the destructions of surrounding structures and layers, and the invaded extent were observed. Read More

Ear Nose Throat J 2014 Oct-Nov;93(10-11):E32-7

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, 325 Cheng-Kung Rd., Section 2, Taipei 114, Taiwan, Republic of China.

We report a unique case of synchronous double hypopharyngeal tumors in a 39-year-old man. The patient presented with a 1-year history of a muffled voice and mild odynophagia. Laryngoscopy detected two grossly different tumors in the hypopharynx: a malignant fibrous histiocytoma (MFH) in the postcricoid area and a squamous cell carcinoma (SCC) in the posterior pharyngeal wall. Read More

Laryngoscope 2015 Feb 23;125(2):356-9. Epub 2014 Jul 23.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India.

Introduction: Postcricoid carcinoma in India, is seen especially in middle-aged females. Surgical treatment for postcricoid carcinoma has reduced because of increased organ-preserving nonsurgical strategies. Surgical intervention leads to morbidity in the form of laryngectomy. Read More

PLoS One 2013 11;8(11):e78718. Epub 2013 Nov 11.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: High-risk human papillomavirus (HPV) is an oncogenic virus that causes oropharyngeal cancers, and it has a favorable outcome after the treatment. Unlike in oropharyngeal cancer, the prevalence and role of high-risk HPV in the etiology of hypopharyngeal squamous cell carcinoma (HPSCC) is uncertain.

Objective: The aim of the present study was to evaluate the effect and prognostic significance of high-risk HPV in patients with HPSCC. Read More

Ear Nose Throat J 2012 May;91(5):204-5

Department of Otolaryngology-Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Laryngeal schwannomas (neurilemmomas) are extremely rare, and they present the otorhinolaryngologist with diagnostic and management challenges. These lesions usually present as a submucosal mass, and they are always a potential threat to the airway. We describe the case of a 75-year-old woman with a laryngeal schwannoma that arose from the left postcricoid area and covered the piriform sinus and arytenoid cartilage on that side. Read More

Laryngorhinootologie 2012 Mar 28;91 Suppl 1:S63-85. Epub 2012 Mar 28.

Universitäts-HNO-Klinik, Universitätsmedizin Mannheim, Mannheim.

The treatment of laryngeal and hypopharyngeal malignancies remains a challenging task for the head and neck surgeon as the chosen treatment modality often has to bridge the gap between oncologically sound radicality and preservation of function. Due to the increase in transoral laser surgery in early tumor stages and chemoradiation in advanced stages, the usage of traditional transcutaneous approaches has decreased over the recent past. In addition, the need for a function-sparing surgical approach as well as highest possible quality of life has become evident. Read More

Laryngoscope 2011 Feb 13;121(2):397-403. Epub 2011 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, University of Connecticut, Farmington, Connecticut, USA.

Objectives/hypothesis: Postcricoid vascular lesions are a rare cause of dysphagia and stridor in the pediatric population. Currently, there is no clear consensus on what type of vascular lesions are common in the postcricoid area because adequate histological or immunohistochemistry studies are lacking. This study aimed to describe the histology and immunohistochemistry of postcricoid masses in our institutions' experience, and consolidate available data on the symptoms, management, and histology of these unusual malformations with a comprehensive literature review. Read More

Kulak Burun Bogaz Ihtis Derg 2010 Nov-Dec;20(6):314-7

Department of Otolaryngology, Medicine Faculty of Ankara University, Ankara, Turkey.

Hemangiomas are the most common vascular tumors mostly (60%) seen in the head-neck region. Head-neck hemangiomas are seen frequently in the oral cavity, rarely in the larynx. Adult laryngeal hemangiomas are rare and often seen in the supraglottic region, therefore causing dysphagia/dysphonia. Read More

Harefuah 2010 Feb;149(2):77-9, 125

Pediatric Otolaryngology Unit, Department of Otolaryngology Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

A 7-months-old female presented with coughing spells while feeding. Flexible laryngoscopy revealed a round bluish mass, emanating from the postcricoid area when the child cried or strained and disappeared when she relaxed. She was treated with systemic steroids for a month and was doing well. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009 Sep;44(9):710-5

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, Jinan, China.

Objective: To review the experience of different surgical construction methods and comprehensive treatments for hypopharyngeal cancer.

Methods: Three hundred and fifty-two cases (According to UICC 2002 criteria, stage I, 3; II, 31; III, 134; IV, 184) with hypopharyngeal cancer were retrospectively reviewed from 1999 to 2005 in the Department of Otorhinolaryngology of Qilu Hospital of Shandong University, including 321 males and 31 females. The median age was 58 years old, ranged from 26 to 82 years old. Read More

Dis Esophagus 2009 ;22(4):E1-5

GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

The inlet patch is an area of heterotopic gastric mucosa most commonly located in the postcricoid portion of the esophagus at, or just below, the level of the upper esophageal sphincter. Esophageal and supraesophageal symptoms are commonly associated with inlet patch, while esophageal adenocarcinoma rarely complicates it. Laryngeal adenocarcinoma associated with inlet patch is not described in the literature. Read More

Auris Nasus Larynx 2008 Jun 6;35(2):304-7. Epub 2008 Feb 6.

Department of Otolaryngology, Head and Neck Surgery, Saitama Medical University, Morohongo 38, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan.

Cases of leiomyosarcoma in the head and neck are very rare with only four reports of a leiomyosarcoma originating in the hypopharynx. A rare case of leiomyosarcoma of the hypopharynx is described. A 62-year-old woman, who had experienced slight difficulty of swallowing and hoarseness, visited our hospital. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2006 Dec;20(12):1183-5

Department of Head and Neck Surgery, Cancer Hospital of Nantong, Nantong Jiangsu, 226361, PR China.

Objective: To study the feasibility, surgical techniques, and results of submental island flaps for reconstruction of hypopharyngeal non-circumferential defects.

Methods: A retrospective review of the archives was performed on 16 patients (6 males, 10 females, aged 41-78 years) who suffered from hypopharyngeal cancer. From August 1998 to August 2002, the patients underwent a partial removal of the hypopharynx and reconstruction by submental island flaps. Read More

Int J Pediatr Otorhinolaryngol 2007 Jan 22;71(1):147-51. Epub 2006 Aug 22.

Otolaryngology Department, Hopital E. Herriot, Place d'Arsonval, 69003 Lyon, France.

To discuss management of postcricoid and upper esophageal hemangiomas in infants. Four children presenting with progressive feeding and/or respiratory disturbance underwent endoscopy including systematic esophagoscopy revealing the hemangioma of the postcricoid area and extending to the lumen of the upper esophagus. In the three children with severe disturbance, systemic steroids were insufficient and open surgical excision brought the hemangioma under control. Read More

Ai Zheng 2005 Nov;24(11):1372-5

Department of Otolhryngology, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, PR China.

Background & Objective: The prolongation of life expectancy results in an increasing number of aged patients with hypopharyngeal carcinoma who have poor surgical tolerance because of degenerative organ functions. This study was to explore the surgical methods and preservation of laryngeal function for aged patients with hypopharyngeal carcinoma.

Methods: Clinical data of 84 patients with hypopharyngeal carcinoma who aged above 60 years, treated from 1996 to 2001, were retrospectively reviewed. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005 Sep;40(9):691-5

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China.

Objective: To review the experience of different surgical construction methods for hypopharyngeal cancer with cervical esophageal invasion.

Methods: From 1989 to 2000,forty-eight patients with advanced hypopharyngeal cancer and cervical esophageal invasion were retrospectively reviewed, including 38 males and 10 females. The median age was 54. Read More

Zhonghua Zhong Liu Za Zhi 2005 Jan;27(1):48-51

Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China.

Objective: To present the treatment results and to identify the most effective therapeutic plan of different therapeutic modalities in patients with squamous-cell carcinoma of hypopharynnx.

Methods: A retrospective review of 464 patients with squamous-cell carcinoma of the hypopharynx treated between 1958 and 1998 was accomplished. The clinical characteristics, results of different treatments were analyzed by SPSS 10. Read More

Radiat Med 2004 Jan-Feb;22(1):30-6

Department of Radiology, Osaka National Hospital, Osaka 540-0006, Japan.

Purpose: We have been treating posterior pharyngeal wall cancer of the oropharynx and hypopharynx with external radiotherapy according to our policy reported in the 1970s.

Materials And Methods: Between 1968 and 1995, 51 patients were treated. Treatment policy was decided on the basis of the treatment response after 40 Gy of radiotherapy. Read More