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Psychiatr Clin North Am 2020 Jun;43(2):305-330

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Traumatic brain injury is a calamity of various causes, pathologies, and extremely varied and often complex clinical presentations. Because of its predilection for brain systems underlying cognitive and complex behavioral operations, it may cause chronic and severe psychiatric illness that requires expert management. This is more so for the modern epidemic of athletic and military brain injuries which are dominated by psychiatric symptoms. Read More

Neuroophthalmology 2020 Jun 9;44(3):157-167. Epub 2019 Oct 9.

Biomedical Engineering Program, University of Manitoba, Winnipeg, MB, Canada.

The vestibular and oculomotor/visual systems are commonly affected in post-concussion syndrome (PCS). Convergence insufficiency (CI) is the most common ocular abnormality after concussion. Electrovestibulography (EVestG) is a relatively new non-invasive method that measures the peripheral vestibular responses; it has shown abnormal vestibular responses in a PCS. Read More

Front Neurol 2020 8;11:249. Epub 2020 Apr 8.

Department of Emergency Medicine, Regions Hospital, St. Paul, MN, United States.

Mild traumatic brain injury (mTBI) causes persisting post-concussion syndrome for many patients without abnormalities on conventional neuroimaging. Currently, there is no method for identifying at-risk cases at an early stage for directing concussion management and treatment. SNTF is a calpain-derived N-terminal proteolytic fragment of spectrin (α-spectrin1-1176) generated in damaged axons following mTBI. Read More

Curr Sports Med Rep 2020 Apr;19(4):151-156

Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

The philosophy and practices concerning concussion management have evolved from passive to active strategies that incorporate immediate, guided rest followed by early integration of physical and cognitive activity as tolerated by symptoms. Recent research and clinical evidence support guidance that symptom tolerable and clinically guided activity is beneficial postconcussion both acutely and in the longer term. Furthermore, recent studies illustrate benefits of targeted deficit-based therapies (vestibular, cervicogenic, visual, psychological, etc. Read More

J Int Neuropsychol Soc 2020 Mar 18:1-13. Epub 2020 Mar 18.

Alberta Children's Hospital Research Institute, Calgary, AB, Canada.

Objective: The long-term effects of pediatric concussion on white matter microstructure are poorly understood. This study investigated long-term changes in white matter diffusion properties of the corpus callosum in youth several years after concussion.

Methods: Participants were 8-19 years old with a history of concussion (n = 36) or orthopedic injury (OI) (n = 21). Read More

Ann Phys Rehabil Med 2020 Mar 12. Epub 2020 Mar 12.

Handiresp EA 4047, UFR Simone Veil-Santé, Université de Versailles St Quentin, Montigny le Bretonneux, France; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, Département Hospitalier d'Epidémiologie et de Santé Publique, Garches, France. Electronic address:

J Clin Med 2020 Mar 4;9(3). Epub 2020 Mar 4.

Tanz Center for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S 1A8, Canada.

Background: Concussion symptoms typically resolve within 7-10 days, but 10%-25% of patients do not fully recover. They can develop post-concussion syndrome (PCS), which includes sleep abnormalities such as obstructive sleep apnea. It is unclear how specific sleep problems manifest in PCS and how it relates to cognition and symptomology. Read More

Front Pediatr 2020 5;8. Epub 2020 Feb 5.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, United States.

The objective of this study was to evaluate concussion-like symptom reporting among uninjured adolescents with Attention-deficit/hyperactivity disorder (ADHD), stratified by several cooccurring conditions, and to examine the base rate and predictors of uninjured adolescents with ADHD meeting diagnostic criteria for the International Classification of Diseases, 10th Revision (ICD-10) post-concussional syndrome (PCS). Participants in this cross-sectional, observational study, were drawn from a cohort of 48,834 adolescent student athletes from Maine (ages 13-18) with no concussion in the past 6 months who completed a preseason, baseline testing program between 2009 and 2015. The final sample included 3,031 students with ADHD, 2,146 (70. Read More

Front Neurol 2020 4;11:43. Epub 2020 Feb 4.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Somatization may contribute to persistent symptoms after mild traumatic brain injury (mTBI). In two independently-recruited study samples, we characterized the extent to which symptoms atypical of mTBI but typical for patients suffering from somatization (e.g. Read More

Data Brief 2020 Apr 31;29:105213. Epub 2020 Jan 31.

AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA.

Resting-state functional Magnetic Resonance Imaging (rs-fMRI) has been extensively used for diagnostic classification because it does not require task compliance and is easier to pool data from multiple imaging sites, thereby increasing the sample size. A MATLAB-based toolbox called Machine Learning in NeuroImaging (MALINI) for feature extraction and disease classification is presented. The MALINI toolbox extracts functional and effective connectivity features from preprocessed rs-fMRI data and performs classification between healthy and disease groups using any of 18 popular and widely used machine learning algorithms that are based on diverse principles. Read More

NeuroRehabilitation 2020 ;46(2):167-180

Niagara Neuropsychology, Grimsby, Ontario, Canada.

Background: Persistent Sport-Related Post-Concussion Syndrome is often diagnosed with any type of prolonged PCS symptoms. However, there are not specific diagnostic criteria for PPCS such that misdiagnosis often occurs. Further, the signs and symptoms of PCS overlap with other common illnesses such as depression, anxiety, migraines, ADHD and others. Read More

Am J Phys Med Rehabil 2020 03;99(3):257-264

From the Department of Medicine, Division of Physical Medicine and Rehabilitation, Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada.

In recent years, there has been a shift away from rest until total symptom resolution after concussion, due to the potential adverse consequences of inactivity. Aerobic exercise has been increasingly investigated for the treatment of postconcussion syndrome, whereby symptoms persist beyond 4 wks. The aim of this review was to systematically review the literature on subsymptom threshold aerobic exercise as a treatment for postconcussion syndrome. Read More

Neurochirurgie 2020 Feb 14. Epub 2020 Feb 14.

University Hospital of Bordeaux, Pole of Emergency Medicine, Inserm, ISPED, Bordeaux Population Health Research Center Inserm U1219 "Injury Epidemiology Transport Occupation" team, Bordeaux cedex, France. Electronic address:

Sci Rep 2020 Feb 14;10(1):2998. Epub 2020 Feb 14.

Biomedical Engineering Program, University of Manitoba, Winnipeg, MB, Canada.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

Can J Neurol Sci 2020 May;47(3):289-300

Faculty of Kinesiology & Health Studies, University of Regina, Regina, Saskatchewan, Canada.

Cannabidiol (CBD) has been generating increasing interest in medicine due to its therapeutic properties and an apparent lack of negative side effects. Research has suggested that high dosages of CBD can be taken acutely and chronically with little to no risk. This review focuses on the neuroprotective effects of a CBD, with an emphasis on its implications for recovering from a mild traumatic brain injury (TBI) or concussion. Read More

BMC Neurol 2020 Feb 5;20(1):46. Epub 2020 Feb 5.

Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation, University of Calgary, Calgary, AB, Canada.

Background: Persistent post-concussive symptoms (PPCS) affect up to 30% of individuals following mild traumatic brain injury. PPCS frequently includes exercise intolerance. Sub-symptom threshold aerobic exercise has been proposed as a treatment option for symptom burden and exercise intolerance in this population. Read More

Open Access Emerg Med 2020 20;12:7-12. Epub 2020 Jan 20.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Minor head trauma is due to the transfer of a mechanical energy to the brain caused by a traumatic event. The present study was accomplished aiming to investigate the cleaved tau protein (CTP) as a brain injury biomarker among patients with minor head trauma.

Patients And Methods: This observational study was performed on patients with minor head trauma in 2017 who referred to emergency department of Imam Khomeini Hospital and Golestan Hospital of Ahvaz, Iran. Read More

Prim Care 2020 Mar 16;47(1):177-188. Epub 2019 Oct 16.

Department of Community Health & Family Medicine and Department of Neurology, University Athletic Association University of Florida, UF Student Health Care Center, 280 Fletcher Dr | PO Box 117500, Gainesville, FL 32611-7500, USA.

Injuries from sports-related head trauma are commonly encountered by primary care providers. These injuries vary in clinical presentation, severity, and outcome, with sports-related concussion (SRC) being the most common and more severe sports-related head trauma, such as hemorrhage, and "second impact syndrome" occurring rarely. Understanding the importance of immediate recognition, removal from play, multimodal evaluation, and typical patterns of recovery is necessary to safely manage an athlete with SRC. Read More

J Neurotrauma 2020 Apr 17. Epub 2020 Apr 17.

Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.

The diagnosis of concussion remains challenging, particularly in cases where several months have passed between a traumatic brain injury (TBI) and clinical assessment. Tracking multiple moving objects in three-dimensional (3D) space engages many of the same cognitive processes that are affected by concussion, a form of mild TBI (mTBI), suggesting that tests of 3D multiple object tracking (3D-MOT) may be sensitive to post-concussion syndrome (PCS) after a brain injury has occurred. To test this, we evaluated 3D-MOT performance (using NeuroTracker) against Sports Concussion Assessment Tool results for cognition, balance, and symptom severity in a large sample ( = 457) of male and female participants between the ages of 6 and 73 years. Read More

Int J Environ Res Public Health 2020 01 4;17(1). Epub 2020 Jan 4.

Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

Although symptom burden and symptom profile severity are independent predictors of post-concussion symptom duration, few studies have examined their effects on prolonged recovery simultaneously. This study examined differences in symptom burden and symptom profile scores between concussed children with prolonged recovery and those with typical recovery. We conducted a retrospective case-control study of concussed children aged 10-18 years. Read More

J Neurotrauma 2020 Mar 18. Epub 2020 Mar 18.

School of Kinesiology and Health Science, York University, Sherman Health Science Research Centre, Toronto, Ontario, Canada.

Fifteen percent of individuals who sustain a concussion go on to develop post-concussion syndrome (PCS). These persistent symptoms are believed to be attributed to damage to white matter tracts and impaired neurotransmission. Specifically, declines in white matter integrity after concussion have been found along the long-coursing axons underlying the frontoparietal network. Read More

FASEB J 2020 Feb 8;34(2):3359-3366. Epub 2020 Jan 8.

Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.

Possible involvement of complement (C) systems in the pathogenesis of traumatic brain injury (TBI) was investigated by quantifying Cproteins in plasma astrocyte-derived exosomes (ADEs) of subjects with sports-related TBI (sTBI) and TBI in military veterans (mtTBI) without cognitive impairment. All sTBI subjects (n = 24) had mild injuries, whereas eight of the mtTBI subjects had moderate, and 17 had mild injuries. Plasma levels of ADEs were decreased after acute sTBI and returned to normal within months. Read More

EClinicalMedicine 2019 Dec 16;17:100214. Epub 2019 Dec 16.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark.

Background: Evidence for effective interventions to prevent long-term sequelae after concussion is sparse. This study aimed to test the efficacy of Get going After concussIoN (GAIN), an interdisciplinary, individually-tailored intervention of 8 weeks duration based on gradual return to activities and principles from cognitive behavioural therapy.

Methods: We conducted an open-label, parallel-group randomised trial in a hospital setting in Central Denmark Region. Read More

J Nurs Meas 2019 12;27(3):361-362

Cephalalgia 2019 Dec 22:333102419896754. Epub 2019 Dec 22.

Boston Children's Hospital, Boston, MA, USA.

Background: Often concussion/mTBI triggers a chronic headache syndrome called persistent post-traumatic headache (P-PTH) that can last from months to years post-injury, and produce significant disruption of childhood education, social interaction and development. Although prevalent and highly disabling, P-PTH is underrepresented in headache and pain research and lacks clear definition and pathophysiology. Clinical presentation of P-PTH frequently resembles that of other headache disorders, like migraine, yet the pathophysiological mechanisms are distinct and not fully understood, making the disorder difficult to treat in the clinical setting. Read More

J Neurotrauma 2020 Feb 13. Epub 2020 Feb 13.

Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Delayed recovery from concussion can dramatically affect a child's social, emotional, and educational development, yet little is known about what causes some children to recover faster than others. The contribution of white matter disruption in children with delayed recovery has been hypothesized, but findings are limited by methodological issues such as: small heterogeneous samples, bias toward children with delayed recovery, and inconsistencies in timing of brain imaging, both within and between studies. The aim of the present study was to assess diffusion neuroimaging correlates of delayed recovery post-concussion in children. Read More

J Neurotrauma 2020 Apr 31;37(7):907-923. Epub 2020 Jan 31.

Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Headaches and pain-related symptoms are the most disabling somatic complaints following mild traumatic brain injury (mTBI). In this study, we reviewed the existing literature examining structural differences in brain morphology and axonal connections, as well as functional differences in brain activity and connectivity associated with pain or post-traumatic headache (PTH) following mTBI. We searched MEDLINE, Embase, PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials, and Web of Science databases for: (1) TBI OR concussion OR post-concussion syndrome; (2) pain OR headache; and (3) magnetic resonance imaging OR functional MRI OR diffusion tensor imaging. Read More

J Neurotrauma 2020 May 31;37(10):1190-1196. Epub 2020 Jan 31.

Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

The purpose of this study was to assess the frequency of structural lesions on conventional magnetic resonance imaging (MRI) of the brain in a large prospective cohort of post-concussion syndrome (PCS) patients. Conventional 3T MRI was used to evaluate 127 prospectively enrolled PCS patients and 29 controls for non-specific white matter hyperintensities (WMH) and traumatic structural lesions, including encephalomalacia, atrophy, microhemorrhage, subarachnoid hemorrhage, and cortical siderosis. All PCS patients had a clinical diagnosis of one or more concussions based on the Concussion in Sport Group (CISG) consensus statements. Read More

J Neurotrauma 2020 May 27;37(10):1183-1189. Epub 2019 Dec 27.

Department of Psychology, National Chengchi University, Taipei, Taiwan.

The objective of this study was to compare patients with acute-to-subacute mild traumatic brain injury (mTBI) on post-concussion symptom reporting based on whether they retrospectively recalled experiencing pre-injury anxiety or depression. Patients with mTBI ( = 297; 40.4% men; mean = 38. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(10):94-102

Pirogov Russian National Research Medical University, Moscow, Russia.

Article is devoted to topical issues of complex diagnosis and treatment of the consequences of traumatic brain injury (TBI) in children, adolescents and adults. Craniocerebral trauma is one of the most important problems of modern neurology, due to the high frequency and severity of disability. In recent years, there has been a steady increase in effects of TBI, a significant part of which are asthenic, autonomic, cognitive, emotional and motor disorders. Read More

CJEM 2019 11;21(6):694-697

Schwartz/Reisman Emergency Medicine Institute.

Handb Clin Neurol 2019 ;166:151-162

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States.

Mild traumatic brain injury (mTBI) is a condition of normal neuroimaging, because conventional MRI is not sensitive to brain lesions. Neurocognitive deficits persist for years after injury in 15% of patients. Persistent TAI can continue after the trauma and contribute to progressive disability. Read More

J Clin Med 2019 Nov 8;8(11). Epub 2019 Nov 8.

Institute of Medical Psychology and Medical Sociology, University Medical Göttingen (UMG), 37075 Göttingen, Germany.

The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) at three and six months post-injury. Patients were included through the prospective cohort study: Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI). Patients enrolled with mTBI (Glasgow Coma Scale 13-15) were further differentiated into complicated and uncomplicated mTBI based on the presence or absence of computed tomography abnormalities, respectively. Read More

Int Emerg Nurs 2020 01 8;48:100810. Epub 2019 Nov 8.

INSERM, ISPED, Bordeaux Population Health Research Center INSERM U1219-"Injury Epidemiology Transport Occupation" Team, F-33076 Bordeaux Cedex, France.

Introduction: Recent research suggests that up to 20% of minor trauma patients admitted to the emergency department (ED) will suffer from non-specific chronic conditions over the subsequent several months. Thus, the present study assessed the correlates of symptoms that persisted at 4 months after an ED visit and, in particular, evaluated the associations between these symptoms and self-reported stress levels at ED admission and discharge.

Method: This study was a prospective observational investigation conducted in the ED of Bordeaux University Hospital that included patients admitted for minor trauma. Read More

Acta Neurol Scand 2020 Feb 20;141(2):183-190. Epub 2019 Nov 20.

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.

Objectives: Previous older adult studies have examined outcome from moderate-to-severe traumatic brain injury (TBI), but fewer have focused on the effects of milder brain injuries. This study examined age-related differences in symptom reporting and whether symptoms are differentially related to functional outcome based on age.

Materials & Methods: Patients presenting with a head injury at the Tampere University Hospital emergency department (N = 325, aged 18-100) were evaluated at 1 week post injury on the Modified Rankin Scale and Rivermead Post Concussion Symptoms Questionnaire (RPQ). Read More

Clin J Sport Med 2019 11;29(6):486-493

Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada.

Objective: To better understand the level of concussion knowledge of youth female hockey coaches and to identify preferred methods of knowledge translation for this population.

Design: Cross-sectional survey.

Setting: Participants independently completed written surveys before in-person concussion information sessions or online surveys through link provided in emails. Read More

Brain Inj 2020 29;34(2):195-202. Epub 2019 Oct 29.

Department of Health Sciences, Lakehead University, Thunder Bay, Ontario, Canada.

Post-concussion syndrome refers to the adverse group of symptoms following a mild traumatic brain injury (mTBI). The Rivermead post-concussion syndrome questionnaire (RPQ) is a common clinical tool for assessing baseline post-concussion syndrome symptomology; however, it is unknown if scores on this questionnaire are associated with future disability. Therefore, the goal of this study was to determine the association between baseline RPQ scores and future disability in older adults with mTBI. Read More

Ir Med J 2019 09 12;112(8):984. Epub 2019 Sep 12.

Cork University Hospital, Wilton, Cork, Ireland

Background This study investigates the prevalence of Post-Concussion Syndrome (PCS) one-year post-injury in patients that were treated for Mild Traumatic Brain Injury (mTBI) in the Clinical Decision Unit (CDU) of Cork University Hospital’s (CUH) Emergency Department. Methods Adults treated for mTBI in 2013 completed a telephone questionnaire comprising the Rivermead Post Concussion Symptoms Questionnaire (RPQ), the Short Form 12 (SF-12), and the EuroQol Health Outcome Assessment Tool (EQ5D5L). Results There were 112 patients identified. Read More

PLoS One 2019 24;14(10):e0210138. Epub 2019 Oct 24.

Institute of Medical Psychology and Medical Sociology, University Medical Center Göttingen (UMG)/ Georg-August-University, Göttingen, Germany.

Background: Traumatic brain injury (TBI) is one of the most common neurological conditions. It can have wide-ranging physical, cognitive and psychosocial effects. Most people recover within weeks to months after the injury, but a substantial proportion are at risk of developing lasting post-concussion symptoms. Read More

Phys Ther Sport 2019 Nov 27;40:184-192. Epub 2019 Sep 27.

University of Mississippi Medical Center Jackson, MS, USA.

Objectives: Deliver a sensorimotor training intervention; quantify the change in clinical measurements of sensorimotor control; and compare injury rate to a historical control.

Design: One-arm experimental pilot; Level 3.

Setting: NCAA Division II university athletic facilities. Read More

PLoS One 2019 2;14(10):e0221892. Epub 2019 Oct 2.

School of Computing, Informatics and Decision Systems Engineering, Arizona State University, Tempe, AZ, United States of America.

Objectives: To (i) investigate alterations in homotopic functional connectivity (hfc) in concussed patients relative to healthy controls (HC) and to (ii) interrogate whether hfc in concussed patients normalized during the recovery process. The relationship between symptom recovery and change in hfc was assessed using post-hoc analyses.

Methods: This study included 15 concussed patients (mean age = 39. Read More

Arch Phys Med Rehabil 2020 01 25;101(1):72-80. Epub 2019 Sep 25.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Objective: To investigate whether cognitive reserve moderates differences in cognitive functioning between patients with mild traumatic brain injury (MTBI) and controls without MTBI and to examine whether patients with postconcussion syndrome have lower cognitive functioning than patients without postconcussion syndrome at 2 weeks and 3 months after injury.

Design: Trondheim MTBI follow-up study is a longitudinal controlled cohort study with cognitive assessments 2 weeks and 3 months after injury.

Setting: Recruitment at a level 1 trauma center and at a general practitioner-run, outpatient clinic. Read More

Front Neurol 2019 4;10:929. Epub 2019 Sep 4.

Department of Neurosurgery, Bicêtre University Hospital, Paris, France.

Unfavorable outcomes (UO) occur in 15-20% of patients with mild traumatic brain injury (mTBI). Early identification of patients at risk of UO is crucial for suitable management to be initiated, increasing the chances of full recovery. We previously developed a prognostic tool for early identification (8-21 days after the injury) of patients likely to develop UO. Read More

Brain Inj 2020 24;34(1):26-33. Epub 2019 Sep 24.

Department of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland.

Mild Traumatic Brain Injury (MTBI) is commonly categorized as when injury severity criteria are mild, but an intracranial abnormality is present on acute neuroimaging. The current study examined whether functional outcomes differed at one week post injury among older adult patients based on injury severity and acute computed tomography (CT) findings. Participants (≥55 years-old; = 173) presenting sequentially to the emergency department with a head injury were divided into three groups: complicated MTBI (positive CT; = 22), uncomplicated MTBI (negative CT; = 68), and mild head injury (unperformed CT, no documented loss of consciousness or post-traumatic amnesia; = 83). Read More

J Neurotrauma 2020 Jan 8;37(2):312-323. Epub 2019 Nov 8.

University of Calgary, Calgary, Alberta, Canada.

Persistent post-traumatic headache (PTH) after mild traumatic brain injury is one of the most prominent and highly reported persistent post-concussion symptoms (PPCS). Non-pharmacological treatments, including non-invasive neurostimulation technologies, have been proposed for use. Our objective was to evaluate headache characteristics at 1 month after repetitive transcranial magnetic stimulation (rTMS) treatment in participants with PTH and PPCS. Read More

J Sci Med Sport 2019 Dec 8;22(12):1292-1297. Epub 2019 Aug 8.

Department of Orthopedic Surgery, UPMC Sports Medicine Concussion Program, University of Pittsburgh Medical Center, USA. Electronic address:

Objectives: The current study investigated the role of persistent vestibular-ocular symptoms and impairment following sport-related concussion on recovery time and clinical outcomes among adolescents.

Design: Prospective cohort.

Methods: 50 (F-22/M-28) adolescents aged 12-20 years completed a vestibular-ocular motor screening, neurocognitive assessment, and the Post-Concussion Symptom Scale (PCSS) at clinical assessments conducted at 0-10 and 11-21 days after concussion. Read More

Mil Med 2020 01;185(Suppl 1):161-167

Department of Surgery, Division of Trauma & Critical Care, Medical College of Wisconsin, 9200 W, Wisconsin Avenue, Milwaukee, WI 53226 Larsen SE, Lorber W, and deRoon-Cassini TA, Are TBI symptoms specific to TBI?, Poster presented at the International Society for Traumatic Stress Studies Thirty-first Annual Meeting in New Orleans, LA, 11/2015. Hunt JC, Larsen SE, Larson ER, Lorber WG, and deRoon-Cassini TA. Interaction between psychiatric symptoms and history of mild TBI when evaluating postconcussion syndrome in Veterans, Poster presented at the annual Military Health Research Symposium in Kissimmee, FL, 08/2018. Abstract number MHSRS-18-0593-TBI.

Introduction: Symptoms of postconcussive syndrome (PCS) after mild TBI (mTBI) have been shown to resolve quickly, yet new research raises questions about possible long-term effects of this condition. It is not clear how best to address assessment and treatment when someone reports lingering symptoms of PCS. One self-report measure used by the VA and the DoD is the Neurobehavioral Symptom Inventory (NSI), but this measure may be affected by underlying psychiatric symptoms. Read More

Psychiatr Danub 2019 Sep;31(Suppl 3):299-307

Department of Neurology, Carrick Institute, Cape Canaveral, FL, USA,

Introduction: There is increasing awareness that Lyme borreliosis (LB) and traumatic brain injury (TBI) may cause mental health symptoms. TBI and Lyme disease compromise the health and activities of millions of patients per year. The chronic symptoms and disability of TBI and Lyme disease share a similar clinical presentation. Read More

Pediatr Rev 2019 Sep;40(9):468-481

Division of Neurology and.

J Clin Med 2019 Aug 27;8(9). Epub 2019 Aug 27.

Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul 03080, Korea.

(1) Background: White matter changes among individuals with mild-to-moderate traumatic brain injury (TBI) may be sensitive imaging markers reflecting functional impairment, particularly in the context of post-concussion syndrome. The objective of this study was to examine the altered white matter integrity in mild-to-moderate TBI patients compared with age-matched normal controls. (2) Methods: Diffusion tensor imaging data from 15 individuals with TBI and 15 control subjects were retrospectively obtained. Read More