114 results match your criteria Post Head Injury Endocrine Complications


Biochemical Mechanisms and Translational Relevance of Hippocampal Vulnerability to Distant Focal Brain Injury: The Price of Stress Response.

Authors:
N V Gulyaeva

Biochemistry (Mosc) 2019 Nov;84(11):1306-1328

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia.

Focal brain injuries (in particular, stroke and traumatic brain injury) induce with high probability the development of delayed (months, years) cognitive and depressive disturbances which are frequently comorbid. The association of these complications with hippocampal alterations (in spite of the lack of a primary injury of this structure), as well as the lack of a clear dependence between the probability of depression and dementia development and primary damage severity and localization served as the basis for a new hypothesis on the distant hippocampal damage as a key link in the pathogenesis of cognitive and psychiatric disturbances. According to this hypothesis, the excess of corticosteroids secreted after a focal brain damage, in particular in patients with abnormal stress-response due to hypothalamic-pituitary-adrenal axis (HPAA) dysfunction, interacts with corticosteroid receptors in the hippocampus inducing signaling pathways which stimulate neuroinflammation and subsequent events including disturbances in neurogenesis and hippocampal neurodegeneration. Read More

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http://dx.doi.org/10.1134/S0006297919110087DOI Listing
November 2019

Lifelong consequences of brain injuries during development: From risk to resilience.

Front Neuroendocrinol 2019 10 24;55:100793. Epub 2019 Sep 24.

Department of Neuroscience, Group in Behavioral Neuroendocrinology, Center for Brain and Spinal Cord Repair, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Traumatic brain injuries in children represent a major public health issue and even relatively mild injuries can have lifelong consequences. However, the outcomes from these injuries are highly heterogeneous, with most individuals recovering fully, but a substantial subset experiencing prolonged or permanent disabilities across a number of domains. Moreover, brain injuries predispose individuals to other kinds of neuropsychiatric and somatic illnesses. Read More

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http://dx.doi.org/10.1016/j.yfrne.2019.100793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905510PMC
October 2019
1 Read
7.037 Impact Factor

Effect of surgeons' annual operative volume on the risk of permanent Hypoparathyroidism, recurrent laryngeal nerve palsy and Haematoma following thyroidectomy: analysis of United Kingdom registry of endocrine and thyroid surgery (UKRETS).

Langenbecks Arch Surg 2019 Jun 28;404(4):421-430. Epub 2019 Jun 28.

Consultant Endocrine Surgeon, Nottingham University Hospitals NHS Trust, City Campus, Nottingham, UK.

Purpose: Categorize data to investigate the surgeon volume outcome relationship in thyroidectomies. Determine the evidence base for recommending a minimum number of thyroidectomies performed per year to maintain surgical competency.

Methods: Data on thyroid operations in the United Kingdom Registry of Endocrine and Thyroid Surgery (UKRETS) from 01/09/2010 to 31/08/2016 was analysed. Read More

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http://dx.doi.org/10.1007/s00423-019-01798-7DOI Listing
June 2019
6 Reads

May predictors of difficulty in thyroid surgery increase the incidence of complications? Prospective study with the proposal of a preoperative score.

BMC Surg 2019 Apr 24;18(Suppl 1):116. Epub 2019 Apr 24.

Department of General Microsurgery and Hand Surgery, "Fabia Mater" Hospital, Rome, Italy.

Background: Although thyroidectomy is one of the most common surgical procedures performed worldwide, some permanent complications, despite the considerably reducing incidence, may affect dramatically the patients quality of life. The purpose of this study is to evaluate whether factors identified preoperatively and expressed in a score could be predictors of major surgical difficulty during total thyroidectomy and influence the incidence of complications.

Methods: A total of 164 patients who underwent total thyroidectomy were examined. Read More

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http://dx.doi.org/10.1186/s12893-018-0447-7DOI Listing
April 2019
13 Reads

Pituitary pathology in traumatic brain injury: a review.

Pituitary 2019 Jun;22(3):201-211

Department of Laboratory Medicine, Division of Pathology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Purpose: Traumatic brain injury most commonly affects young adults under the age of 35 and frequently results in reduced quality of life, disability, and death. In long-term survivors, hypopituitarism is a common complication.

Results: Pituitary dysfunction occurs in approximately 20-40% of patients diagnosed with moderate and severe traumatic brain injury giving rise to growth hormone deficiency, hypogonadism, hypothyroidism, hypocortisolism, and central diabetes insipidus. Read More

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http://dx.doi.org/10.1007/s11102-019-00958-8DOI Listing
June 2019
11 Reads
2.222 Impact Factor

Pituitary deficiency and precocious puberty after childhood severe traumatic brain injury: a long-term follow-up prospective study.

Eur J Endocrinol 2019 May;180(5):281-290

Paediatric Endocrinology, Gynaecology and Diabetology Unit, Assistance Publique-Hôpitaux de Paris, Necker Enfants-Malades University Hospital, Paris, France.

Objectives Childhood traumatic brain injury (TBI) is a public health issue. Our objectives were to determine the prevalence of permanent pituitary hormone deficiency and to detect the emergence of other pituitary dysfunctions or central precocious puberty several years after severe TBI. Design Follow-up at least 5 years post severe TBI of a prospective longitudinal study. Read More

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http://dx.doi.org/10.1530/EJE-19-0034DOI Listing
May 2019
10 Reads

The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.

Pituitary 2019 Jun;22(3):249-260

Academic Department of Endocrinology, Beaumont Hospital and the RCSI Medical School, Beaumont Road, Dublin 9, Ireland.

Purpose: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, debate still exists about the true prevalence of hypopituitarism after head injury.

Methods: We have reviewed the literature describing the frequency of post-traumatic hypopituitarism and discuss the factors which may explain the variable frequency of the reported deficits in clinical studies including research methodology and the natural history of the disease. Read More

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http://dx.doi.org/10.1007/s11102-019-00938-yDOI Listing
June 2019
6 Reads

Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal nerve injury in adults undergoing thyroid surgery.

Cochrane Database Syst Rev 2019 Jan 19;1:CD012483. Epub 2019 Jan 19.

Department of General Surgery, University of Perugia, Terni, Italy, 05100.

Background: Injuries to the recurrent inferior laryngeal nerve (RILN) remain one of the major post-operative complications after thyroid and parathyroid surgery. Damage to this nerve can result in a temporary or permanent palsy, which is associated with vocal cord paresis or paralysis. Visual identification of the RILN is a common procedure to prevent nerve injury during thyroid and parathyroid surgery. Read More

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http://dx.doi.org/10.1002/14651858.CD012483.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353246PMC
January 2019
40 Reads

Hypoxic stress: A risk factor for post-concussive hypopituitarism?

Med Hypotheses 2018 Dec 6;121:31-34. Epub 2018 Sep 6.

Vienna Chiropractic Associates, P.C. (Private Practice of Chiropractic), 243 Church Street NW, #300-B, Vienna, VA 22180, USA. Electronic address:

Hypopituitarism diagnosed months or years following concussive injury can cause a variety of endocrine disturbances including insufficient secretion of human growth, luteinizing, follicle stimulating, thyroid stimulating, adrenocorticotrophic, and antidiuretic hormones. Recent evidence suggests that autoimmune reactions against pituitary and/or hypothalamic tissue constitute an etiologic factor for this hypopituitarism. One important trigger for autoimmunity is hypoxic stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183058
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http://dx.doi.org/10.1016/j.mehy.2018.09.012DOI Listing
December 2018
37 Reads

The interplay between neuroendocrine and sleep alterations following traumatic brain injury.

NeuroRehabilitation 2018 ;43(3):327-345

Centre for Neuro Skills, Encino, CA, USA.

Background: Sleep and endocrine disruptions are prevalent after traumatic brain injury (TBI) and are likely to contribute to morbidity.

Objective: To describe the interaction between sleep and hormonal regulation following TBI and elucidate the impact that alterations of these systems have on cognitive responses during the posttraumatic chronic period.

Methods: Review of preclinical and clinical literature describing long-lasting endocrine dysregulation and sleep alterations following TBI. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/NRE-182483DOI Listing
January 2019
24 Reads

Posterior pituitary dysfunction following traumatic brain injury: review.

Pituitary 2019 Jun;22(3):296-304

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.

Neurohypophysial dysfunction is common in the first days following traumatic brain injury (TBI), manifesting as dysnatremia in approximately 1 in 4 patients. Both hyponatremia and hypernatremia can impair recovery from TBI and in the case of hypernatremia, there is a significant association with excess mortality. Hyponatremia secondary to syndrome of inappropriate antidiuretic hormone secretion (SIAD) is the commonest electrolyte disturbance following TBI. Read More

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http://link.springer.com/10.1007/s11102-018-0917-z
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http://dx.doi.org/10.1007/s11102-018-0917-zDOI Listing
June 2019
37 Reads

The incidence of vocal fold motion impairment after primary thyroid and parathyroid surgery for a single high-volume academic surgeon determined by pre- and immediate post-operative fiberoptic laryngoscopy.

Int J Surg 2018 Aug 14;56:73-78. Epub 2018 Jun 14.

Division of Head and Neck Endocrine Surgery, Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Background: Vocal fold motion impairment (VFMI) is a well-recognized complication of thyroid and parathyroid surgery. Preoperative counseling requires a thorough understanding of the incidence, risk factors, and value of early diagnosis of postoperative VFMI. Our objective is to describe the incidence of and risk factors for VFMI for a single high-volume academic surgeon, and to assess the utility of immediate postoperative fiberoptic laryngoscopy (FOL) in early diagnosis of VFMI. Read More

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http://dx.doi.org/10.1016/j.ijsu.2018.06.014DOI Listing
August 2018
57 Reads

The Impact of Traumatic Brain Injury on Later Life: Effects on Normal Aging and Neurodegenerative Diseases.

J Neurotrauma 2018 01 27;35(1):17-24. Epub 2017 Oct 27.

1 Centre for Neuro Skills Clinical Research and Education Foundation , Bakersfield, California.

The acute and chronic effects of traumatic brain injury (TBI) have been widely described; however, there is limited knowledge on how a TBI sustained during early adulthood or mid-adulthood will influence aging. Epidemiological studies have explored whether TBI poses a risk for dementia and other neurodegenerative diseases associated with aging. We will discuss the influence of TBI and resulting medical comorbidities such as endocrine, sleep, and inflammatory disturbances on age-related gray and white matter changes and cognitive decline. Read More

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http://dx.doi.org/10.1089/neu.2017.5103DOI Listing
January 2018
23 Reads

Transoral endoscopic thyroidectomy vestibular approach (TOETVA): indications, techniques and results.

Surg Endosc 2018 Jan 17;32(1):456-465. Epub 2017 Jul 17.

Department of Otolaryngology Head Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA.

Introduction: The Transoral Neck Surgery (TONS) Study Group was established at the 1st International Thyroid NOTES Conference in February 2016 with the intention of standardizing and refining thyroid NOTES techniques, including both transoral endoscopic and robotic thyroidectomy approaches. Herein, the authors report the modification of indications, preparation, and step-by-step explanations for operative techniques, as well as results and postoperative care for transoral endoscopic thyroidectomy vestibular approach (TOETVA).

Methods: Between February 2015 and December 2015, a total of 200 patients comprising 8 males (4%) and 192 females (96%) underwent TOETVA using 3 laparoscopic ports inserted at the oral vestibule. Read More

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http://dx.doi.org/10.1007/s00464-017-5705-8DOI Listing
January 2018
42 Reads

Timing and extension of lymphadenectomy in medullary thyroid carcinoma: A case series from a single institution.

Int J Surg 2017 May;41 Suppl 1:S70-S74

University of Perugia, Medical School, Endocrine Surgery Unit, S. Maria University Hospital, Terni, Italy. Electronic address:

Background: Medullary thyroid carcinoma is an aggressive tumor and presents with significant morbidity and mortality and a high rate of lymph node metastases. The combination of total thyroidectomy and cervical lymphadenectomy is the essential treatment for those patients presenting with cervical lymph node metastases.

Materials And Methods: A retrospective analysis of 117 patients operated for medullary thyroid carcinoma over a period of 15 years at a single institution. Read More

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http://dx.doi.org/10.1016/j.ijsu.2017.04.026DOI Listing
May 2017
29 Reads

Preoperative vitamin D level as predictor of post-thyroidectomy hypocalcemia in patients sustaining transient parathyroid injury.

Head Neck 2017 07 29;39(7):1378-1381. Epub 2017 Mar 29.

Department of Otolaryngology - Head and Neck Surgery, Division of Head and Neck Oncologic and Microvascular Surgery, University of Virginia Health System, Charlottesville, Virginia.

Background: Several studies have sought to identify predictors of postoperative hypocalcemia after total thyroidectomy; however, there have been conflicting results regarding the impact of preoperative vitamin D deficiency.

Methods: The medical records of patients undergoing total thyroidectomy were retrospectively reviewed. The number of parathyroid glands identified or reimplanted at the time of surgery was used as a marker of transient parathyroid gland damage. Read More

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http://dx.doi.org/10.1002/hed.24775DOI Listing
July 2017
7 Reads

Delayed Diagnosis of TSH-Secreting Adenoma Attributed to Worsening Post-Traumatic Stress Disorder Symptoms in a Military Veteran Because of Provider Anchoring Bias.

Mil Med 2017 03;182(3):e1849-e1853

Endocrinology Service, Department of Medicine, San Antonio Military Medical Center, 3851 Roger Brooke Drive, JBSA-Fort Sam Houston, TX 78234.

Introduction: Anchoring bias occurs when clinicians hold on to previously known information about a patient, with failure to consider the full realm of possibilities to explain new findings. We present a case of delayed diagnosis of thyroid-stimulating-hormone-secreting pituitary adenoma (TSHoma), a rare disorder, in a military veteran whose symptoms were misconstrued as being caused from worsening of his prior diagnosis of post-traumatic stress disorder (PTSD). Anchoring bias in this case led to 2-year delay in the correct diagnosis. Read More

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http://dx.doi.org/10.7205/MILMED-D-16-00241DOI Listing
March 2017
13 Reads

Can early clinical parameters predict post-traumatic pituitary dysfunction in severe traumatic brain injury?

Acta Neurochir (Wien) 2016 12 25;158(12):2347-2353. Epub 2016 Oct 25.

Ist Department of Internal Medicine, University of Pécs, 13 Ifjusag, Pécs, Hungary, 7624.

Background: Post-traumatic hypopituitarism is a major complication after severe head trauma. The aim of our study was to evaluate the possible role of early clinical parameters in the development of endocrine deficits.

Methods: Data on endocrine function, on-admission clinical-, laboratory-, and ICU-monitored parameters were available in 63 patients of the surviving 86 severe head injury patients (post-resuscitation GCS under 8) treated at one neurosurgical center during a 10-year period. Read More

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http://link.springer.com/10.1007/s00701-016-2995-x
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http://dx.doi.org/10.1007/s00701-016-2995-xDOI Listing
December 2016
12 Reads

Prospective study of hypothalamo-hypophyseal dysfunction in children and adolescents following traumatic brain injury.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Mar 19;161(1):80-85. Epub 2016 Sep 19.

Department of Pediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.

Background And Aims: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase.

Patients And Methods: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS). Read More

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http://dx.doi.org/10.5507/bp.2016.047DOI Listing
March 2017
46 Reads

Endocrine dysfunction following traumatic brain injury: a 5-year follow-up nationwide-based study.

Sci Rep 2016 09 9;6:32987. Epub 2016 Sep 9.

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.

Post-traumatic endocrine dysfunction is a complication of traumatic brain injury (TBI). However, there is lack of long-term follow-up and large sample size studies. This study included patients suffering from TBI registered in the Health Insurance Database. Read More

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http://dx.doi.org/10.1038/srep32987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017132PMC
September 2016
17 Reads

Neuroendocrine Disturbances One to Five or More Years after Traumatic Brain Injury and Aneurysmal Subarachnoid Hemorrhage: Data from the German Database on Hypopituitarism.

J Neurotrauma 2016 08 31;33(16):1544-53. Epub 2016 Mar 31.

11 Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry , Munich, Germany .

Neuroendocrine disturbances are common after traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH), but only a few data exist on long-term anterior pituitary deficiencies after brain injury. We present data from the Structured Data Assessment of Hypopituitarism after TBI and SAH, a multi-center study including 1242 patients. We studied a subgroup of 351 patients, who had sustained a TBI (245) or SAH (106) at least 1 year before endocrine assessment (range 1-55 years) in a separate analysis. Read More

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http://dx.doi.org/10.1089/neu.2015.4109DOI Listing
August 2016
47 Reads

[Hypopituitarism following traumatic brain injury: diagnostic and therapeutic issues].

Authors:
A-L Lecoq P Chanson

Ann Endocrinol (Paris) 2015 Oct;76(6 Suppl 1):S10-8

INSERM Unité 1185, Faculté de Médecine Paris-Sud, 63 rue Gabriel Péri, 94276 Le Kremlin Bicêtre, France; Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie et des Maladies de la Reproduction, Hôpital Bicêtre, 94275 Le Kremlin Bicêtre, France; Université Paris-Sud, UMR S1185, 94276 Le Kremlin-Bicêtre, France.

Traumatic Brain Injury (TBI) is a well-known public health problem worldwide and is a leading cause of death and disability, particularly in young adults. Besides neurological and psychiatric issues, pituitary dysfunction can also occur after TBI, in the acute or chronic phase. The exact prevalence of post-traumatic hypopituitarism is difficult to assess due to the wide heterogeneity of published studies and bias in interpretation of hormonal test results in this specific population. Read More

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http://dx.doi.org/10.1016/S0003-4266(16)30003-8DOI Listing
October 2015
44 Reads

International survey on the identification and neural monitoring of the EBSLN during thyroidectomy.

Laryngoscope 2016 Jan 9;126(1):285-91. Epub 2015 Oct 9.

Department of Head and Neck Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Objectives/hypothesis: Surgical management of the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomy is complex. We hypothesized that there exist variations in surgical behaviors patterns in the management of the EBSLN during thyroidectomy.

Study Design: A prospective Web-based anonymous survey (www. Read More

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http://dx.doi.org/10.1002/lary.25548DOI Listing
January 2016
51 Reads

GH deficiency after traumatic brain injury: improvement in quality of life with GH therapy: analysis of the KIMS database.

Eur J Endocrinol 2015 Apr 12;172(4):371-81. Epub 2015 Jan 12.

Department of Obesity and EndocrinologyInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool L9 7AL, UKPfizer Endocrine CarePfizer, Inc., Sollentuna, SwedenBarts and the London School of Medicine and DentistryWilliam Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, London, UKDepartment of Women's and Children's HealthUppsala University, Uppsala, Sweden

Objective: Prevalence of GH deficiency (GHD) caused by traumatic brain injury (TBI) is highly variable. Short-term studies show improvement in quality of life (QoL) during GH replacement (GHR), but long-term data are lacking. The aim of this study was to analyse the clinical characteristics of post-traumatic hypopituitarism and the QoL effects of long-term GHR. Read More

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http://www.eje-online.org/content/172/4/371.full.pdf
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http://www.eje-online.org/cgi/doi/10.1530/EJE-14-0654
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http://dx.doi.org/10.1530/EJE-14-0654DOI Listing
April 2015
61 Reads

Predictors of post-traumatic pituitary failure during long-term follow-up.

Hormones (Athens) 2015 Jul-Sep;14(3):383-91

Objective: There is increasing awareness among physicians of the risks of traumatic brain injury (TBI)-induced hypopituitarism. We have assessed the prevalence and risk factors of post-traumatic hypopituitarism by analyzing the TBI database of the University of Pecs.

Design: This consecutive analysis of 126 TBI survivors (mean age: 42. Read More

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http://dx.doi.org/10.14310/horm.2002.1564DOI Listing
May 2016
57 Reads

Differential recurrent laryngeal nerve palsy rates after thyroidectomy.

Surgery 2014 Nov 17;156(5):1157-66. Epub 2014 Oct 17.

Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.

Introduction: Recurrent laryngeal nerve (RLN) palsy is a devastating complication of thyroidectomy. Although neurapraxia is thought to be the most common cause, the underlying mechanisms are poorly understood. The objectives of this study were to examine the differential palsy rates between the left and right RLNs, and the role of intraoperative nerve swelling as a risk factor of postoperative palsy. Read More

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http://dx.doi.org/10.1016/j.surg.2014.07.018DOI Listing
November 2014
35 Reads

Sleep and wake disturbances following traumatic brain injury.

Pathol Biol (Paris) 2014 Oct 7;62(5):252-61. Epub 2014 Aug 7.

Center for advanced research in sleep medicine, hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1C5, Canada; Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Québec, Canada. Electronic address:

Traumatic brain injury (TBI) is a major health concern in industrialised countries. Sleep and wake disturbances are among the most persistent and disabling sequelae after TBI. Yet, despite the widespread complaints of post-TBI sleep and wake disturbances, studies on their etiology, pathophysiology, and treatments remain inconclusive. Read More

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http://dx.doi.org/10.1016/j.patbio.2014.05.014DOI Listing
October 2014
13 Reads

Adipsic diabetes insipidus and venous thromboembolism (VTE): recommendations for addressing its hypercoagulability.

Hormones (Athens) 2014 Jul-Sep;13(3):420-3

Clinic of Endocrinology, Medical Faculty, Belgrade University, Clinical Center of Serbia, Belgrade, Serbia.

Adipsic diabetes insipidus (ADI) is a rare disorder. It can occur after transcranial surgery for craniopharyngeoma, suprasellar pituitary adenoma and anterior communicating artery aneurysm but also with head injury, toluene exposure and developmental disorders. It is often associated with significant hypothalamic dysfunction and complications like obesity, sleep apnea, thermoregulatory disorders, seizures and venous thromboembolism (VTE). Read More

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http://dx.doi.org/10.14310/horm.2002.1496DOI Listing
October 2015
33 Reads

Traumatic brain injury and neuro-endocrine disruption: medical and psychosocial rehabilitation.

NeuroRehabilitation 2014 ;34(4):625-36

The Chicago School of Professional Psychology, Chicago, IL, USA.

Introduction: Traumatic Brain Injury (TBI) initiates a cascade of neuromodulatory damage that blurs the distinctions between physical and psychological medicine. Monitoring endocrine function through labs is not part of the medical care algorithm for treatment of TBI, but the clinical symptoms are easily misidentified as they include: depression, fatigue, poor concentration, irritability and a decline in overall cognitive functioning. The reciprocal flow of change between neuroendocrine health and psychosocial health is well established within the field of neuroscience, social psychology, endocrinology and behavioral neurology, but has not translated into patient care. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/NRE-141074DOI Listing
October 2014
76 Reads

Sensorimotor cortex ablation induces time-dependent response of ACTH cells in adult rats: behavioral, immunohistomorphometric and hormonal study.

Physiol Behav 2014 Feb 27;125:30-7. Epub 2013 Nov 27.

Department of Cytology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia.

Traumatic brain injury (TBI) represents a serious event with far reaching complications, including pituitary dysfunction. Pars distalis corticotropes (ACTH cells), that represent the active module of hypothalamo-pituitary-adrenocortical axis, seem to be affected as well. Since pituitary failure after TBI has been associated with neurobehavioral impairments the aim of this study was to evaluate the effects of TBI on recovery of motor functions, morphology and secretory activity of ACTH cells in the pituitary of adult rats. Read More

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http://dx.doi.org/10.1016/j.physbeh.2013.11.005DOI Listing
February 2014
16 Reads

Inhibition of natriuresis in median eminence polydipsia: effects after intake of diets with different osmolalities and after hypertonic NaCl administration.

Acta Neurobiol Exp (Wars) 2013 ;73(3):326-37

Department of Psychobiology, University of Granada, Granada, Spain,

Lesions in the hypothalamic median eminence (ME) induce polydipsia and polyuria in male rats. A first experiment was designed to examine the effect of salt consumption (standard 0.25 percent Na+ vs. Read More

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April 2014
11 Reads

Impact of neuromonitoring of recurrent laryngeal nerve and surgical loupes on the outcome of thyroidectomy. A retrospective chart review.

Saudi Med J 2013 Aug;34(8):824-8

Department of Otolaryngology, Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Objective: To determine whether the post-operative complication rate of thyroidectomy can be reduced using surgical loupes to identify parathyroid gland and recurrent laryngeal nerve (RLN) with simultaneous intraoperative neuromonitoring of RLN.

Methods: This retrospective chart review was conducted from December 2012 to March 2013 at the Ear, Nose, Throat, and Head-Neck Department of King Saud Hospital, Riyadh, Kingdom of Saudi Arabia. The study group included patients who underwent primary thyroid surgeries performed from July 2007 to September 2011, older than 16 years old, without history of vocal cord palsy, hypocalcemia, and sternotomy. Read More

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August 2013
22 Reads

Pituitary function and functional outcome in adults after severe traumatic brain injury: the long-term perspective.

J Neurotrauma 2013 Feb;30(4):271-80

Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Post-traumatic hypopituitarism (PTHP) has been linked to disability and decreased quality of life. However, no studies have addressed the long-term consequences of PTHP in adults with severe traumatic brain injury (TBI) only. In this study, we evaluated the relationship between pituitary function, quality of life, and functioning in 51 patients (16-65 years of age) with severe TBI who were admitted to Sahlgrenska University Hospital, Gothenburg from 1999 to 2002. Read More

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http://dx.doi.org/10.1089/neu.2012.2494DOI Listing
February 2013
20 Reads

Sutureless total thyroidectomy: a safe and cost-effective alternative.

ANZ J Surg 2011 Jul-Aug;81(7-8):510-4

University of Sydney Endocrine Surgical Unit, NSW, Australia.

Background: Advanced vessel sealing devices provide an alternative to conventional ligation techniques for thyroidectomy. To date, most studies have been inadequately powered to explore differences in the infrequent post-operative complications following thyroidectomy. This study is designed to compare the outcomes of sutureless thyroidectomy and conventional thyroidectomy for recurrent laryngeal nerve (RLN) injury, permanent hypoparathyroidism, and haematoma formation. Read More

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http://dx.doi.org/10.1111/j.1445-2197.2010.05492.xDOI Listing
May 2012
12 Reads

Structured assessment of hypopituitarism after traumatic brain injury and aneurysmal subarachnoid hemorrhage in 1242 patients: the German interdisciplinary database.

J Neurotrauma 2011 Sep 29;28(9):1693-8. Epub 2011 Aug 29.

Medizinische Klinik-Innenstadt, Ludwig Maximilians University, Munich, Germany.

Clinical studies have demonstrated that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) are frequent causes of long-term disturbances of hypothalamo-pituitary function. This study aimed to assess the prevalence and associated factors of post-traumatic hypopituitarism in a large national registry of patients with TBI and SAH. Data were collected from 14 centers in Germany and Austria treating patients for TBI or SAH and performing endocrine assessments. Read More

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http://dx.doi.org/10.1089/neu.2011.1887DOI Listing
September 2011
28 Reads

Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats.

Brain Res 2011 Mar 22;1382:298-307. Epub 2011 Jan 22.

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China.

Emerging evidence demonstrates that severe illness could induce critical illness-related corticosteroid insufficiency (CIRCI) and cause poor prognosis. The purpose of this study was to test the hypothesis that methylprednisolone (MP), a synthetic glucocorticoid, promotes post-traumatic apoptosis in both the hypothalamus and pituitary, resulting in acute CIRCI and increased mortality in the acute phase of traumatic brain injury (TBI). We tested this hypothesis by measuring acute CIRCI in rats subjected to fluid percussion injury (FPI) and treated with MP (5-30mg/kg). Read More

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http://dx.doi.org/10.1016/j.brainres.2011.01.045DOI Listing
March 2011
13 Reads

Spontaneous recovery from isolated post-traumatic central hypogonadism in a woman.

Hormones (Athens) 2010 Oct-Dec;9(4):332-7

Clinical Experimental Department of Medicine and Pharmacology, Section of Endocrinology, Policlinico Universitario G. Martino, University of Messina, Messina, Italy.

Objective: Hypopituitarism is a recognized complication of Traumatic Brain Injury (TBI). Resolution of established anterior pituitary hormones deficiency is rare.

Case Report: A woman was initially presented at the age of 22 years with amenorrhoea. Read More

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http://www.hormones.gr/pdf/332-337.pdf
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http://dx.doi.org/10.14310/horm.2002.1285DOI Listing
March 2011
14 Reads

Transarterial embolization of traumatic carotid-superior hypophyseal arterial cavernous fistula. A case report.

Interv Neuroradiol 2010 Sep 25;16(3):278-81. Epub 2010 Oct 25.

Department of Neurosurgery, Fudan University, Shanghai, China.

A 26-year-old man presented with symptoms of progressive bilateral exophthalmos and swelling of the eyelids after a severe head injury. Angiography confirmed a direct carotid-superior hypophyseal arterial (SHA) cavernous fistula with petrosal sinus and intracavernous sinus drainage. Successful transarterial coil embolization of the fistula was performed with resolution of the patient's symptoms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278002PMC
http://dx.doi.org/10.1177/159101991001600308DOI Listing
September 2010
9 Reads

Fatigue after traumatic brain injury: Association with neuroendocrine, sleep, depression and other factors.

Brain Inj 2010 ;24(12):1379-88

PM&R, San Jose, CA, USA.

Objective: Define associations between post-traumatic brain injury (TBI) fatigue and abnormalities in neuroendocrine axes, sleep, mood, cognition and physical functioning.

Design: Survey.

Setting: Large community hospital-based rehabilitation centre. Read More

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http://www.tandfonline.com/doi/full/10.3109/02699052.2010.52
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http://dx.doi.org/10.3109/02699052.2010.523041DOI Listing
February 2011
33 Reads

[First manic episode in the elderly--consider a subdural haematoma due to head trauma as cause].

Ned Tijdschr Geneeskd 2010 ;154:A1235

De Gelderse Roos, afd. Ouderen, Arnhem, The Netherlands.

A manic episode in old age presents a diagnostic challenge to the clinician due to the different symptomatology often difficult to distinguish from delirium, dementia, agitated depression and psychosis. To complicate matters further, a first episode of mania in later life is very often based on underlying physical and cerebral pathology ('secondary mania'). Many causes of 'secondary mania', including neurological, systemic or endocrine diseases, infections, intoxications, apnoea, post-thoracic surgery and vitamin B12 deficiency have been described to date, but there have been no reports on subdural haematomas in this context. Read More

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June 2010
17 Reads

Salivary biosensors for screening trauma-related psychopathology.

Oral Maxillofac Surg Clin North Am 2010 May;22(2):269-78

Section of Oral and Maxillofacial Surgery, 23-009 UCLA School of Dentistry, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA.

After facial trauma, a distinct subset of patients goes on to develop mental health problems including recalcitrant psychopathology. Early identification of maladaptive stress reactions provides opportunities for initiating preemptive mental health interventions and hinges on the surgeon's ability to differentiate between transient distress and precursors of recalcitrant psychiatric sequelae. The comprehensive care of injured patients will benefit greatly from objective adjuncts and decision-making tools to complement the clinical evaluation. Read More

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http://dx.doi.org/10.1016/j.coms.2010.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858052PMC
May 2010
10 Reads

[Late evaluation of the pituitary-gonadal axis in survivors of severe traumatic brain injury].

Arq Bras Endocrinol Metabol 2009 Nov;53(8):1012-9

Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.

Objective: The purpose of this study is to evaluate pituitary function impairment in order to verify the prevalence of sex hormone deficiency and to analyze the profile of TBI population.

Methods: Thirty patients were studied, 22 were male and 8 were female. All patients had their gonadal function assessed and they were evaluated at a median of 4 years post-trauma. Read More

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http://dx.doi.org/10.1590/s0004-27302009000800016DOI Listing
November 2009
24 Reads

Hypogonadism after traumatic brain injury.

Arq Bras Endocrinol Metabol 2009 Nov;53(8):908-14

Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.

Traumatic brain injury (TBI) is the most common cause of death and disability in young adults. Post-TBI neuroendocrine disorders have been increasingly acknowledged in recent years due to their potential contribution to morbidity and, probably, to mortality after trauma. Marked alterations of the hypothalamic-pituitary axis during the post-TBI acute and chronic phases have been reported. Read More

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http://dx.doi.org/10.1590/s0004-27302009000800003DOI Listing
November 2009
28 Reads

Delayed diagnosis of hypopituitarism following severe traumatic brain injury.

BMJ Case Rep 2010 Sep 29;2010. Epub 2010 Sep 29.

Department of Rehabilitation Medicine, Rookwood Hospital, Cardiff, UK.

The following case illustrates a 10-year delay in the diagnosis of hypopituitarism after severe traumatic brain injury in a 22-year-old man crushed by a forklift truck. His symptoms of mood changes, headaches and sleep pattern disturbances were attributed to post traumatic brain injury syndrome resulting in a delay in diagnosing the underlying pathology. Following recurrent episodes of symptomatic hyponatraemia, hypopituitarism was diagnosed. Read More

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http://dx.doi.org/10.1136/bcr.12.2009.2526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028089PMC
September 2010
62 Reads
1 Citation

Long-term outcome of functional post-thyroidectomy voice and swallowing symptoms.

Surgery 2009 Dec;146(6):1174-81

Division of Endocrine Surgery, Department of Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Voice and swallowing symptoms are frequently reported early after thyroidectomy even in the absence of laryngeal nerves injury. We evaluated the short-term and long-term outcomes of these functional alterations.

Methods: Consenting patients undergoing total thyroidectomy (TT) were enrolled. Read More

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http://dx.doi.org/10.1016/j.surg.2009.09.010DOI Listing
December 2009
26 Reads

Permanent central diabetes insipidus after mild traumatic brain injury.

Brain Inj 2009 Dec;23(13-14):1095-8

Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan, PR China.

Aim: The patients in the permanent diabetes insipidus (DI) group are more likely to have more severe TBI, which is defined by a post-resuscitational and pre-sedational Glasgow Coma Scale (GCS) score of 8/15 or less. This study presents a case of permanent, central DI following mild traumatic brain injury with post-resuscitation GCS 13/15.

Case Report: A 17-year-old boy suffered from mild brain injury and experienced permanent DI without any anatomical changes on image in the early stage of traumatic brain injury. Read More

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http://dx.doi.org/10.3109/02699050903379396DOI Listing
December 2009
32 Reads

Early stress response: a vulnerability framework for functional impairment following mild traumatic brain injury.

Res Theory Nurs Pract 2009 ;23(1):42-61

Michigan State University, USA.

Nearly 64% of people with mild traumatic brain injury (MTBI) experience prolonged symptoms and functional impairments lasting months or years postinjury. Explanations for delayed recovery have varied and lacked a guiding framework, hindering intervention science. Using theory substruction and adapting McLean and associates' biopsychosocial model for chronic pain after trauma, we suggest that perceived psychological stress and associated neurobiological responses may predict risk for functional impairment. Read More

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http://dx.doi.org/10.1891/1541-6577.23.1.42DOI Listing
July 2009
76 Reads

Traumatic brain injury causes long-term reduction in serum growth hormone and persistent astrocytosis in the cortico-hypothalamo-pituitary axis of adult male rats.

J Neurotrauma 2009 Aug;26(8):1315-24

Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Unlabelled: In humans, traumatic brain injury (TBI) causes pathological changes in the hypothalamus (HT) and the pituitary. One consequence of TBI is hypopituitarism, with deficiency of single or multiple hormones of the anterior pituitary (AP), including growth hormone (GH). At present no animal model of TBI with ensuing hypopituitarism has been demonstrated. Read More

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http://dx.doi.org/10.1089/neu.2008.0751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850256PMC
August 2009
11 Reads

Surgical complications after endoscopic transsphenoidal pituitary surgery.

J Clin Neurosci 2009 Jun 16;16(6):786-9. Epub 2009 Mar 16.

Department of Neurosurgery, Johannes Gutenberg University Mainz, Mainz, Germany.

Between January 2004 and June 2007 we conducted a retrospective analysis to assess post-operative complications related to endoscopic pituitary surgery in a series of 150 patients. Patients were treated with an endoscopic endonasal transsphenoidal approach to the sellar region for removal of pathological sellar and suprasellar lesions. We analysed the complications in groups according to the anatomical structures of the approach and the functional systems of the pituitary gland (anterior and posterior endocrine systems), and compared them to a large historical series using the traditional microsurgical transsphenoidal approach. Read More

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http://dx.doi.org/10.1016/j.jocn.2008.09.002DOI Listing
June 2009
13 Reads

Neuroendocrine disorders after traumatic brain injury.

J Neurol Neurosurg Psychiatry 2008 Jul;79(7):753-9

Academic Department of Endocrinology, Beaumont Hospital and RCSI Medical School, Dublin, Ireland.

Traumatic brain injury (TBI) is the most common cause of death and disability in young adults living in industrialised countries, in which 180-250 persons per 100 000 per year die or are hospitalised as a result. Neuroendocrine derangements after TBI have received increasing recognition in recent years because of their potential contribution to morbidity, and possibly mortality, after trauma. Marked changes of the hypothalamo-pituitary axis have been documented in the acute phase of TBI, with as many as 80% of patients showing evidence of gonadotropin deficiency, 18% of growth hormone deficiency, 16% of corticotrophin deficiency and 40% of patients demonstrating vasopressin abnormalities leading to diabetes insipidus or the syndrome of inappropriate anti-diuresis. Read More

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http://jnnp.bmj.com/cgi/doi/10.1136/jnnp.2007.132837
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http://dx.doi.org/10.1136/jnnp.2007.132837DOI Listing
July 2008
12 Reads