Search Our Scientific Publications & Authors

J Ophthalmol 2021 2;2021:6687929. Epub 2021 Jun 2.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.

Purpose: To analyze how keratic precipitate (KP) morphology changes during Posner-Schlossman syndrome (PSS) prognosis and raise medication suggestions on 2% ganciclovir eye drops.

Materials And Methods: Clinical retrospective cohort study in the Eye & ENT Hospital of Fudan University, Shanghai, China. The attacked eyes of 98 eligible subjects diagnosed unilateral PSS were enrolled between 2016 and 2019. Read More

Int Ophthalmol 2021 May 28. Epub 2021 May 28.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The patterns of uveitis in Tokyo have recently changed due to advances in examination tools. We aimed to investigate the changes in the patterns of uveitis between 2004-2015 and 2016-2018.

Methods: We retrospectively reviewed the data of 732 patients who visited the Uveitis Clinic at the University of Tokyo Hospital between January 2016 and December 2018. Read More

Br J Ophthalmol 2021 Mar 22. Epub 2021 Mar 22.

Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.

Aims: The aim of this observational study was to report the distribution of glycoprotein B (gB) genotypes in the eyes of cytomegalovirus (CMV) positive patients with Posner-Schlossman syndrome (PSS), and to investigate their clinical characteristics and outcomes.

Methods: We collected aqueous humour samples from 165 patients clinically diagnosed with PSS between 2017 and 2019. PCR was performed to analyse the CMV DNA and identify the gB genotypes in the samples. Read More

Semin Ophthalmol 2021 Mar 18:1-9. Epub 2021 Mar 18.

Glaucoma Services, LV Prasad Eye Institute, Patia, Bhubaneswar, Odisha, India.

Purpose: To report unusual associations, atypical clinical presentations, and outcomes of tailored treatment of viral uveitis and glaucoma.

Methods: Patients diagnosed with viral uveitis with associated glaucoma, seen at a tertiary eye care center between 2013 and 2020, were screened. Twenty-four patients with unclassified or atypical clinical presentations of viral uveitis, atypical clinical course, or with diagnostic challenges and associated glaucoma, were included. Read More

Front Immunol 2021 24;12:607966. Epub 2021 Feb 24.

Department of Ophthalmology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are well-known key immune checkpoints that play a crucial dampening effect on regulating T-cell homeostasis and self-tolerance. In this study, we aimed to evaluate the association between immune checkpoints (CTLA-4 and PD-1) and Posner-Schlossman syndrome (PSS) in a southern Chinese population. A total of 137 patients with PSS and 139 healthy controls from a southern Chinese population were recruited. Read More

Jpn J Ophthalmol 2021 Mar 11;65(2):184-190. Epub 2021 Mar 11.

Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.

Purpose: To investigate the epidemiology of uveitis in Japan and assess its changes over time.

Study Design: Retrospective multicenter study METHODS: Sixty-six hospitals in Japan with uveitis specialty clinics participated in this retrospective nationwide survey. A questionnaire was sent to each hospital to survey the total number of patients who made a first visit to the outpatient uveitis clinic of each hospital between 1 April 2016 and 31 March 2017. Read More

Front Immunol 2021 11;12:608723. Epub 2021 Feb 11.

Department of Ophthalmology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University & The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.

Posner-Schlossman syndrome (PSS), also known as glaucomatocyclitic crisis, is an ocular condition characterized by recurrent attacks of anterior uveitis and raised intraocular pressure. Previous studies by our team and others have identified the genetic association of complement pathway genes with uveitis and glaucoma. This study aimed to investigate the complement genes in PSS patients with the view of elucidating the genetic background of the disease. Read More

Case Rep Ophthalmol Med 2020 15;2020:8843586. Epub 2020 Oct 15.

Allergy/Immunology Associates Inc., Mayfield Heights, Ohio, USA.

Introduction: Posner-Schlossman syndrome (PSS) is a rare glaucomatocyclitic crisis with clinical features including recurrent episodes of unilateral elevated intraocular pressure. Autoimmune and infectious causes have been proposed as potential etiologies of PSS. We report the first case of PSS in the setting of common variable immunodeficiency (CVID). Read More

Clin Ophthalmol 2020 24;14:2799-2806. Epub 2020 Sep 24.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.

Purpose: To review clinical characteristics of ocular inflammation patients in Osaka, Japan, over 20 years and investigate the efficacy of required surgeries.

Methods: We conducted a retrospective study involving 2730 eyes of 1815 patients with ocular inflammation examined at the Osaka Medical College Hospital from April 1999 to March 2019.

Results: Patients comprised 843 males and 972 females, with a mean age of 56. Read More

Cesk Slov Oftalmol 2020 ;76(1):29-36

The objective of this study was a retrospective assessment of two-year experience with micropulse cyclophotocoagulation (MP CPC) in the therapy of various types of glaucoma.

Material And Method: The cohort of patients consisted of 47 people, out of which 16 men and 31 women. An average age of males was 58. Read More

Indian J Ophthalmol 2020 09;68(9):1764-1773

Centre for Ophthalmology, University of Tuebingen, Germany.

Viral anterior uveitis (VAU) needs to be suspected in anterior uveitis (AU) associated with elevated intraocular pressure, corneal involvement, and iris atrophic changes. Common etiologies of VAU include herpes simplex, varicella-zoster, cytomegalovirus, and rubella virus. Clinical presentations can vary from granulomatous AU with corneal involvement, Posner-Schlossman syndrome, Fuchs uveitis syndrome, and endothelitis. Read More

Ocul Immunol Inflamm 2020 Aug 18:1-7. Epub 2020 Aug 18.

Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: To identify viral pathogens in patients with secondary glaucoma associated with anterior segment uveitis and compare metagenomic deep sequencing (MDS) with enzyme-linked immunosorbent assay (ELISA) combined with Witmer-Desmonts coefficient (WDC) evaluation and real-time quantitative polymerase chain reaction (qPCR) on investigating pathogens in aqueous humor.

Methods: Aqueous humor from 31 patients, including 22 Posner-Schlossman Syndrome and 9 other anterior uveitis, was assessed pathogens by ELISA combined with WDC evaluation, virus deoxyribonucleic acid (DNA) detection by real-time qPCR and MDS.

Results: Viral pathogens (HCMV or VZV or RV) were detected in 19 out of 31 eyes (61. Read More

Invest Ophthalmol Vis Sci 2020 08;61(10)

,.

Purpose: To examine the role of aqueous tumor necrosis factor α (TNF-α)-RhoA-Rho kinase (ROCK) signaling in cytomegalovirus (CMV)-induced apoptosis and the barrier function of cultured human corneal endothelial cells (hCECs) in CMV-positive Posner-Schlossman syndrome (CMV+/PSS) patients.

Methods: Aqueous levels of TNF-α, IL-8, IL-10, and several other cytokines in 19 CMV+/PSS patients and 20 healthy control subjects were quantitated using a multiplex assay. The expression of active RhoA in hCECs post-CMV infection was determined using western blotting (WB). Read More

Sci Rep 2020 04 14;10(1):6265. Epub 2020 Apr 14.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

To examine whether autotaxin (ATX) in the aqueous humor causes elevated intraocular pressure (IOP) in patients with Posner-Schlossman syndrome (PSS). ATX and transforming growth factor beta (TGF-β) in the aqueous humor were quantified in PSS patients. The expression of ATX and TGF-β in cytomegalovirus (CMV)-infected-human trabecular meshwork (hTM) cells was examined. Read More

Cureus 2020 Jan 7;12(1):e6584. Epub 2020 Jan 7.

Emergency Medicine, Envision Physician Services, Orlando, USA.

We present the case of a patient who presented to the Emergency Department with Posner-Schlossman syndrome, also known as glaucomatocyclitic crisis. While this condition is uncommon, it is essential that physicians be aware of its characteristics and how to treat it, otherwise affected patients are at risk of developing permanent complications such as optic nerve atrophy and loss of vision. Read More

Ann Transl Med 2019 Dec;7(23):749

School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen 518040, China.

Background: The polymorphisms of classical and loci have been associated with Posner-Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical (e.g. Read More

Int Ophthalmol 2020 Apr 2;40(4):877-889. Epub 2020 Jan 2.

Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan, 528000, People's Republic of China.

Purpose: To compare the choroidal thickness (CT) of the affected eyes with the contralateral eyes in the active period and in the remission period in Posner-Schlossman syndrome (PSS) using EDI-OCT.

Patients And Methods: This prospective longitudinal study included 15 patients with PSS and 15 age- and sex-matched healthy subjects. All subjects underwent complete ophthalmologic examinations, and EDI-OCT was conducted to measure macular CT (mCT) at the subfoveal locations and at 0. Read More

Front Pharmacol 2019 7;10:1322. Epub 2019 Nov 7.

Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

The Posner-Schlossman syndrome (PSS) is a disease with clinically recurrent unilateral anterior uveitis with markedly elevated intraocular pressure (IOP) and subsequent progression to optic neuropathy. Retrospective studies have reported increased annual incidence of PSS, especially in China. While currently, the clinical management of PSS is still challenging. Read More

Medicine (Baltimore) 2019 Nov;98(48):e18123

Department of Ophthalmology, Gifu University Graduate School of Medicine.

This retrospective observational study aims to report the clinical characteristics and surgical results in eyes with Posner-Schlossman syndrome (PSS), and compare these outcomes between cytomegalovirus (CMV)-positive and -negative eyes.We reviewed the medical records of 21 consecutive immunocompetent patients clinically diagnosed with PSS between the years 2010 and 2018. Aqueous humor was collected from all the affected eyes to detect if CMV was present, and polymerase chain reaction (PCR) was performed using the herpesvirus family primers. Read More

Ocul Immunol Inflamm 2021 Jan 23;29(1):160-168. Epub 2019 Oct 23.

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Ophthalmology Department and Laboratory and DHU Sight Restore, Paris, France.

: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin.: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc.: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. Read More

Exp Eye Res 2019 10 26;187:107777. Epub 2019 Aug 26.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, People's Republic of China; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China. Electronic address:

The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of TLR2, TLR3, TLR4 and TLR9 genes are associated with susceptibility to presumed viral-induced anterior uveitis (PVIAU) and Posner-Schlossman syndrome (PSS). A case-control study was performed in 205 PVIAU patients and 1007 healthy controls. A total of 15 SNPs were genotyped by MassARRAY platform and iPLEX Gold Assay. Read More

Int Ophthalmol 2019 Dec 27;39(12):2785-2795. Epub 2019 May 27.

Department of Ophthalmology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Purpose: To compare the clinical findings in patients with anterior uveitis (AU) caused by herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegalovirus (CMV).

Methods: We retrospectively analyzed the clinical profiles of HSV-AU (14 patients), VZV sine herpete (ZSH-AU: 21 patients), and CMV-AU (17 patients) diagnosed by the detection of corresponding viral DNA in aqueous humor samples by polymerase chain reaction. Further, five patients with Posner-Schlossman (P-S) syndrome were selected as controls for CMV-AU. Read More

Ocul Immunol Inflamm 2020 May 25;28(4):538-548. Epub 2019 Apr 25.

Glaucoma division, Department of Ophthalmology, Phramongkutklao Hospital, Phramongkutklao college of Medicine , Bangkok, Thailand.

Objective: The objective of this article is to determine characteristics and outcome of hypertensive anterior uveitis and prevalence of the Herpesviridae family. Study: Retrospective cohort study.

Methods: A total of 64 anterior uveitis participants with increased intraocular pressure and Herpesviridae family polymerase chain reaction (PCR) analysis results were included. Read More

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

Niger J Clin Pract 2019 Jan;22(1):138-143

Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.

The aim of this study is to describe the effectiveness of trabeculectomy with mitomycin C and releasable suture in Posner-Schlossman syndrome (PSS) with secondary glaucoma. Early treatment is the key to successful management of PSS with secondary glaucoma. However, unremitting exposure of high intraocular pressure (IOP) because of the high recurrence rate of PSS may cause further optic nerve damage and visual field defect. Read More

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):833-838

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, NHC Key Laboratory of Myopia(Fudan University); Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China.

To observe the effect of 2% ganciclovir eye drops on Posner-Schlossman syndrome (PSS) patients with positive cytomegalovirus (CMV) in aqueous humor. Prospective study. The cases clinically diagnosed as PSS with positive CMV were enrolled from August 2017 to January 2018 at Department of Ophthalmology, Eye & ENT Hospital of Fudan University. Read More

Clin Exp Ophthalmol 2019 05 3;47(4):513-520. Epub 2018 Dec 3.

Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: To compare the detection results consistency of quantitative polymerase chain reaction (qPCR) and digital droplet polymerase chain reaction (ddPCR), and determine the value of ddPCR for viral detection in the aqueous humour.

Methods: A total of 130 aqueous humour samples were collected, including 60 patients with Posner-Schlossman syndrome (PSS) in case group and 70 elderly patients with senile cataract in control group. The target nucleic acid fragments of human cytomegalovirus (HCMV), herpes simplex virus, Epstein-Barr virus and varicella zoster virus in aqueous humour were analysed by qPCR and ddPCR, respectively, for the diagnosis and curative effect monitoring of pathogen-induced PSS. Read More

Clin Exp Ophthalmol 2019 04 13;47(3):320-333. Epub 2018 Nov 13.

Singapore National Eye Centre, Singapore, Singapore.

A viral aetiology should be suspected when anterior uveitis is accompanied by ocular hypertension, diffuse stellate keratic precipitates or the presence of iris atrophy. The most common viruses associated with anterior uveitis include herpes simplex virus, varicella-zoster virus, cytomegalovirus and rubella virus. They may present as the following: Firstly, granulomatous cluster of small and medium-sized keratic precipitates in Arlt's triangle, with or without corneal scars, suggestive of herpes simplex or varicella-zoster virus infection. Read More

Curr Opin Ophthalmol 2018 Nov;29(6):535-542

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, USA.

Purpose Of Review: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts.

Recent Findings: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium. Read More

BMC Ophthalmol 2018 Sep 29;18(1):259. Epub 2018 Sep 29.

Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106, The second zhongshan road, Guangzhou, 510080, Guangdong, China.

Background: Cytomegalovirus can cause ocular anterior uveitis with ocular hypertension. Basis on the therapy, ocular pressure usually can be controlled. We report a case of a man who had unilateral cytomegalovirus anterior uveitis with refractory glaucoma during the process of treatment. Read More