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Front Physiol 2022 1;13:886871. Epub 2022 Jun 1.

Eye Center of Xiangya Hospital, Central South University, Changsha, China.

The study aimed to evaluate the effect of intraocular pressure (IOP) reduction on macular and peripapillary microcirculation in patients with Posner-Schlossman syndrome (PSS) by optical coherence tomography angiography (OCTA). A prospective comparative study was conducted. Patients diagnosed with PSS at the Eye Center of Xiangya Hospital, Central South University, from February 2020 to November 2021 were consecutively included. Read More

Ocul Immunol Inflamm 2022 Apr 12:1-9. Epub 2022 Apr 12.

Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Purpose: To evaluate vessel density (VD) and structural features in Posner-Schlossman syndrome (PSS) patients' eyes using optical coherence tomography angiography (OCTA).

Methods: An observational study was conducted among 23 affected eyes (group A), 23 contralateral unaffected eyes (group B), and 23 control eyes (group C).

Result: The macular superficial, macular deep, and optic nerve head (ONH) VD of group A were 45. Read More

Front Med (Lausanne) 2022 9;9:848820. Epub 2022 Mar 9.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Background: To observe and compare the efficacy of 2% ganciclovir eye drops in the treatment of Posner-Schlossman Syndrome relapses with/without cytomegalovirus intraocular reactivation.

Methods: A prospective cohort study enrolling 101 patients diagnosed unilateral Posner-Schlossman Syndrome in Eye & ENT hospital, Fudan University, Shanghai, China. Thorough ophthalmic examinations were given. Read More

BMC Ophthalmol 2022 Mar 22;22(1):130. Epub 2022 Mar 22.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Background: We aimed to analyze the clinical characteristics of secondary glaucoma related to cytomegalovirus (CMV)- and varicella zoster virus (VZV)-positive uveitis.

Methods: In this retrospective study, we enrolled patients with anterior uveitic secondary glaucoma. All the patients underwent aqueous and serum analyses for viral antibody through enzyme-linked immunosorbent assay. Read More

Exp Eye Res 2022 05 8;218:109009. Epub 2022 Mar 8.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Accumulated clinical evidence has shown that Posner-Schlossman syndrome (PSS) is most likely the result of recurrent human cytomegalovirus (HCMV) infection in the anterior chamber (AC). Establishing an animal model is necessary to investigate the pathogenesis of PSS. In this study, we constructed a mouse model of (PSS) by injecting murine cytomegalovirus (MCMV) into the AC of BALB/c mice. Read More

Am J Ophthalmol 2022 05 5;237:290-298. Epub 2022 Jan 5.

From the Department of Ophthalmology, Charité-Universitaetsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt Universitaet zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Purpose: To report objective morphologic changes in cytomegalovirus (CMV)-positive Posner-Schlossman syndrome (PSS).

Design: Retrospective, consecutive case series.

Methods: We reviewed the charts of patients with unilateral PSS tested positive for CMV by Goldmann-Witmer coefficients between 2007 and 2018 at our tertiary eye clinic. Read More

Invest Ophthalmol Vis Sci 2022 01;63(1)

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: The purpose of this study was to investigate trabecular meshwork (TM) and Schlemm's canal (SC) morphology in Posner-Schlossman syndrome (PSS).

Methods: Forty-five patients with PSS were recruited. TM thickness and length as well as SC area and diameter of both affected and fellow eyes were assessed using swept-source optical coherence tomography. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Dec 23;259(12):3757-3767. Epub 2021 Jul 23.

Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: The aim of this study is to investigate the long-term prognosis for glaucoma in patients with Posner-Schlossman syndrome (PSS).

Methods: In this retrospective case series study, a total of 98 patients with PSS from January 2014 to February 2019 were included in this study. Initial presentations and follow-up data were obtained from medical records. Read More

J Ophthalmol 2021 2;2021:6687929. Epub 2021 Jun 2.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.

Purpose: To analyze how keratic precipitate (KP) morphology changes during Posner-Schlossman syndrome (PSS) prognosis and raise medication suggestions on 2% ganciclovir eye drops.

Materials And Methods: Clinical retrospective cohort study in the Eye & ENT Hospital of Fudan University, Shanghai, China. The attacked eyes of 98 eligible subjects diagnosed unilateral PSS were enrolled between 2016 and 2019. Read More

Int Ophthalmol 2021 Jul 28;41(7):2377-2388. Epub 2021 May 28.

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: The patterns of uveitis in Tokyo have recently changed due to advances in examination tools. We aimed to investigate the changes in the patterns of uveitis between 2004-2015 and 2016-2018.

Methods: We retrospectively reviewed the data of 732 patients who visited the Uveitis Clinic at the University of Tokyo Hospital between January 2016 and December 2018. Read More

Br J Ophthalmol 2021 Mar 22. Epub 2021 Mar 22.

Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.

Aims: The aim of this observational study was to report the distribution of glycoprotein B (gB) genotypes in the eyes of cytomegalovirus (CMV) positive patients with Posner-Schlossman syndrome (PSS), and to investigate their clinical characteristics and outcomes.

Methods: We collected aqueous humour samples from 165 patients clinically diagnosed with PSS between 2017 and 2019. PCR was performed to analyse the CMV DNA and identify the gB genotypes in the samples. Read More

Semin Ophthalmol 2021 Nov 18;36(8):605-613. Epub 2021 Mar 18.

Glaucoma Services, LV Prasad Eye Institute, Patia, Bhubaneswar, Odisha, India.

Purpose: To report unusual associations, atypical clinical presentations, and outcomes of tailored treatment of viral uveitis and glaucoma.

Methods: Patients diagnosed with viral uveitis with associated glaucoma, seen at a tertiary eye care center between 2013 and 2020, were screened. Twenty-four patients with unclassified or atypical clinical presentations of viral uveitis, atypical clinical course, or with diagnostic challenges and associated glaucoma, were included. Read More

Front Immunol 2021 24;12:607966. Epub 2021 Feb 24.

Department of Ophthalmology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.

Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) are well-known key immune checkpoints that play a crucial dampening effect on regulating T-cell homeostasis and self-tolerance. In this study, we aimed to evaluate the association between immune checkpoints (CTLA-4 and PD-1) and Posner-Schlossman syndrome (PSS) in a southern Chinese population. A total of 137 patients with PSS and 139 healthy controls from a southern Chinese population were recruited. Read More

Jpn J Ophthalmol 2021 Mar 11;65(2):184-190. Epub 2021 Mar 11.

Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.

Purpose: To investigate the epidemiology of uveitis in Japan and assess its changes over time.

Study Design: Retrospective multicenter study METHODS: Sixty-six hospitals in Japan with uveitis specialty clinics participated in this retrospective nationwide survey. A questionnaire was sent to each hospital to survey the total number of patients who made a first visit to the outpatient uveitis clinic of each hospital between 1 April 2016 and 31 March 2017. Read More

Front Immunol 2021 11;12:608723. Epub 2021 Feb 11.

Department of Ophthalmology, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University & The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.

Posner-Schlossman syndrome (PSS), also known as glaucomatocyclitic crisis, is an ocular condition characterized by recurrent attacks of anterior uveitis and raised intraocular pressure. Previous studies by our team and others have identified the genetic association of complement pathway genes with uveitis and glaucoma. This study aimed to investigate the complement genes in PSS patients with the view of elucidating the genetic background of the disease. Read More

Case Rep Ophthalmol Med 2020 15;2020:8843586. Epub 2020 Oct 15.

Allergy/Immunology Associates Inc., Mayfield Heights, Ohio, USA.

Introduction: Posner-Schlossman syndrome (PSS) is a rare glaucomatocyclitic crisis with clinical features including recurrent episodes of unilateral elevated intraocular pressure. Autoimmune and infectious causes have been proposed as potential etiologies of PSS. We report the first case of PSS in the setting of common variable immunodeficiency (CVID). Read More

Clin Ophthalmol 2020 24;14:2799-2806. Epub 2020 Sep 24.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.

Purpose: To review clinical characteristics of ocular inflammation patients in Osaka, Japan, over 20 years and investigate the efficacy of required surgeries.

Methods: We conducted a retrospective study involving 2730 eyes of 1815 patients with ocular inflammation examined at the Osaka Medical College Hospital from April 1999 to March 2019.

Results: Patients comprised 843 males and 972 females, with a mean age of 56. Read More

Cesk Slov Oftalmol 2020 ;76(1):29-36

The objective of this study was a retrospective assessment of two-year experience with micropulse cyclophotocoagulation (MP CPC) in the therapy of various types of glaucoma.

Material And Method: The cohort of patients consisted of 47 people, out of which 16 men and 31 women. An average age of males was 58. Read More

Indian J Ophthalmol 2020 09;68(9):1764-1773

Centre for Ophthalmology, University of Tuebingen, Germany.

Viral anterior uveitis (VAU) needs to be suspected in anterior uveitis (AU) associated with elevated intraocular pressure, corneal involvement, and iris atrophic changes. Common etiologies of VAU include herpes simplex, varicella-zoster, cytomegalovirus, and rubella virus. Clinical presentations can vary from granulomatous AU with corneal involvement, Posner-Schlossman syndrome, Fuchs uveitis syndrome, and endothelitis. Read More

Ocul Immunol Inflamm 2022 Jan 18;30(1):153-159. Epub 2020 Aug 18.

Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: To identify viral pathogens in patients with secondary glaucoma associated with anterior segment uveitis and compare metagenomic deep sequencing (MDS) with enzyme-linked immunosorbent assay (ELISA) combined with Witmer-Desmonts coefficient (WDC) evaluation and real-time quantitative polymerase chain reaction (qPCR) on investigating pathogens in aqueous humor.

Methods: Aqueous humor from 31 patients, including 22 Posner-Schlossman Syndrome and 9 other anterior uveitis, was assessed pathogens by ELISA combined with WDC evaluation, virus deoxyribonucleic acid (DNA) detection by real-time qPCR and MDS.

Results: Viral pathogens (HCMV or VZV or RV) were detected in 19 out of 31 eyes (61. Read More

Invest Ophthalmol Vis Sci 2020 08;61(10)

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Purpose: To examine the role of aqueous tumor necrosis factor α (TNF-α)-RhoA-Rho kinase (ROCK) signaling in cytomegalovirus (CMV)-induced apoptosis and the barrier function of cultured human corneal endothelial cells (hCECs) in CMV-positive Posner-Schlossman syndrome (CMV+/PSS) patients.

Methods: Aqueous levels of TNF-α, IL-8, IL-10, and several other cytokines in 19 CMV+/PSS patients and 20 healthy control subjects were quantitated using a multiplex assay. The expression of active RhoA in hCECs post-CMV infection was determined using western blotting (WB). Read More

Sci Rep 2020 04 14;10(1):6265. Epub 2020 Apr 14.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

To examine whether autotaxin (ATX) in the aqueous humor causes elevated intraocular pressure (IOP) in patients with Posner-Schlossman syndrome (PSS). ATX and transforming growth factor beta (TGF-β) in the aqueous humor were quantified in PSS patients. The expression of ATX and TGF-β in cytomegalovirus (CMV)-infected-human trabecular meshwork (hTM) cells was examined. Read More

Cureus 2020 Jan 7;12(1):e6584. Epub 2020 Jan 7.

Emergency Medicine, Envision Physician Services, Orlando, USA.

We present the case of a patient who presented to the Emergency Department with Posner-Schlossman syndrome, also known as glaucomatocyclitic crisis. While this condition is uncommon, it is essential that physicians be aware of its characteristics and how to treat it, otherwise affected patients are at risk of developing permanent complications such as optic nerve atrophy and loss of vision. Read More

Ann Transl Med 2019 Dec;7(23):749

School of Ophthalmology & Optometry Affiliated to Shenzhen University, Shenzhen 518040, China.

Background: The polymorphisms of classical and loci have been associated with Posner-Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical (e.g. Read More

Int Ophthalmol 2020 Apr 2;40(4):877-889. Epub 2020 Jan 2.

Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan, 528000, People's Republic of China.

Purpose: To compare the choroidal thickness (CT) of the affected eyes with the contralateral eyes in the active period and in the remission period in Posner-Schlossman syndrome (PSS) using EDI-OCT.

Patients And Methods: This prospective longitudinal study included 15 patients with PSS and 15 age- and sex-matched healthy subjects. All subjects underwent complete ophthalmologic examinations, and EDI-OCT was conducted to measure macular CT (mCT) at the subfoveal locations and at 0. Read More

Precis Clin Med 2019 Dec 29;2(4):283-287. Epub 2019 Nov 29.

Eye Institute, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.

A 54-year-old woman presented with recurrent redness and blurred vision of the left eye with elevated intraocular pressure (IOP) for one year. She was treated as "iridocyclitis" and ``Posner-Schlossman syndrome'' at the local hospitals. However, the patient developed intermittent ocular inflammation and hyphema. Read More

Front Pharmacol 2019 7;10:1322. Epub 2019 Nov 7.

Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

The Posner-Schlossman syndrome (PSS) is a disease with clinically recurrent unilateral anterior uveitis with markedly elevated intraocular pressure (IOP) and subsequent progression to optic neuropathy. Retrospective studies have reported increased annual incidence of PSS, especially in China. While currently, the clinical management of PSS is still challenging. Read More

Medicine (Baltimore) 2019 Nov;98(48):e18123

Department of Ophthalmology, Gifu University Graduate School of Medicine.

This retrospective observational study aims to report the clinical characteristics and surgical results in eyes with Posner-Schlossman syndrome (PSS), and compare these outcomes between cytomegalovirus (CMV)-positive and -negative eyes.We reviewed the medical records of 21 consecutive immunocompetent patients clinically diagnosed with PSS between the years 2010 and 2018. Aqueous humor was collected from all the affected eyes to detect if CMV was present, and polymerase chain reaction (PCR) was performed using the herpesvirus family primers. Read More

Ocul Immunol Inflamm 2021 Jan 23;29(1):160-168. Epub 2019 Oct 23.

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Ophthalmology Department and Laboratory and DHU Sight Restore, Paris, France.

: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin.: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc.: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. Read More