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Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

Niger J Clin Pract 2019 Jan;22(1):138-143

Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.

The aim of this study is to describe the effectiveness of trabeculectomy with mitomycin C and releasable suture in Posner-Schlossman syndrome (PSS) with secondary glaucoma. Early treatment is the key to successful management of PSS with secondary glaucoma. However, unremitting exposure of high intraocular pressure (IOP) because of the high recurrence rate of PSS may cause further optic nerve damage and visual field defect. Read More

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):833-838

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, NHC Key Laboratory of Myopia(Fudan University); Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China.

To observe the effect of 2% ganciclovir eye drops on Posner-Schlossman syndrome (PSS) patients with positive cytomegalovirus (CMV) in aqueous humor. Prospective study. The cases clinically diagnosed as PSS with positive CMV were enrolled from August 2017 to January 2018 at Department of Ophthalmology, Eye & ENT Hospital of Fudan University. Read More

Clin Exp Ophthalmol 2018 Nov 9. Epub 2018 Nov 9.

Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: To compare the detection results consistency of quantitative polymerase chain reaction (qPCR) and digital droplet polymerase chain reaction (ddPCR), and determine the value of ddPCR for viral detection in the aqueous humour.

Methods: A total of 130 aqueous humour samples were collected, including 60 patients with Posner-Schlossman syndrome (PSS) in case group and 70 elderly patients with senile cataract in control group. The target nucleic acid fragments of human cytomegalovirus (HCMV), herpes simplex virus, Epstein-Barr virus and varicella zoster virus in aqueous humour were analysed by qPCR and ddPCR, respectively, for the diagnosis and curative effect monitoring of pathogen-induced PSS. Read More

Clin Exp Ophthalmol 2018 Oct 21. Epub 2018 Oct 21.

Singapore National Eye Centre, Singapore, Singapore.

A viral aetiology should be suspected when anterior uveitis is accompanied by ocular hypertension, diffuse stellate keratic precipitates or the presence of iris atrophy. The most common viruses associated with anterior uveitis include herpes simplex virus, varicella-zoster virus, cytomegalovirus and rubella virus. They may present as the following: Firstly, granulomatous cluster of small and medium-sized keratic precipitates in Arlt's triangle, with or without corneal scars, suggestive of herpes simplex or varicella-zoster virus infection. Read More

BMC Ophthalmol 2018 Sep 29;18(1):259. Epub 2018 Sep 29.

Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106, The second zhongshan road, Guangzhou, 510080, Guangdong, China.

Background: Cytomegalovirus can cause ocular anterior uveitis with ocular hypertension. Basis on the therapy, ocular pressure usually can be controlled. We report a case of a man who had unilateral cytomegalovirus anterior uveitis with refractory glaucoma during the process of treatment. Read More

J Glaucoma 2019 Jan;28(1):e10-e13

Department of Ophthalmology, University Hospitals of Coventry and Warwickshire, Coventry, UK.

Purpose: The purpose of this case series is to report development of acute secondary optic neuropathy due to optic nerve injury associated with single episode of acutely raised intraocular pressure (IOP) of varying etiologies.

Patients And Methods: Retrospective review of a series of 3 consecutive cases diagnosed at University hospitals of Coventry and Warwickshire and review of published literature.

Results: Three cases, respectively, with Posner Schlossman syndrome, acute idiopathic hypertensive anterior uveitis, and primary acute angle-closure initially presented with raised IOPs of 38 to 68 mm Hg. Read More

Int Ophthalmol 2018 Sep 4. Epub 2018 Sep 4.

Wuhan Clinical Medical School of Southern Medical University, No. 627 Wuluo Road, Wuchang District, Wuhan City, 430070, Hubei Province, China.

Purpose: To investigate the characteristic of intraocular pressure (IOP) dynamic change from episode to intermittent period in patients with Posner-Schlossman syndrome (PSS).

Patients And Methods: Seventeen cases of typical PSS were collected in this study. Both their random IOP in episodes/intermittent period and 24-h IOP in intermittent period were measured. Read More

Am J Ophthalmol Case Rep 2018 Sep 19;11:23-25. Epub 2018 Apr 19.

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute & Tianjin Medical University School of Optometry and Ophthalmology, No. 251, Fukang R., Nankai Dist, Tianjin, China.

Purpose: To describe a case of interface fluid formation caused by uncontrollable intraocular pressure (IOP) 16 years after laser-assisted in situ keratomileusis (LASIK) surgery secondary to Posner Schlossman Syndrome (PSS).

Observations: After trabeculectomy operation, IOP of the operative eye was back to normal, and the interface fluid refluxed over time.

Conclusions: and importance: Interface Fluid Syndrome can be a potential lifelong complication after LASIK surgery. Read More

PLoS One 2018 26;13(6):e0199301. Epub 2018 Jun 26.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Posner-Schlossman-Syndrome (PSS) is clinically characterized by acute, recurrent, mild, unilateral uveitis anterior accompanied by elevated intraocular pressure (IOP). Fuchs´ Uveitis (FU) is a chronic, low-grade-inflammatory disorder, involving anterior uvea and vitreous. The clinical findings show remarkable similarities as well as differences. Read More

Ocul Immunol Inflamm 2018 Feb 23:1-6. Epub 2018 Feb 23.

b Department of Ophthalmology , Hospital Universitario de la Princesa , Madrid , Spain.

Purpose: Describing the utility of Polymerase Chain Reaction for Cytomegalovirus (CMV-PCR) in the diagnosis of suspected viral anterior uveitis (AU).

Patients And Methods: We analyzed aqueous humor (AH) CMV-PCR positivity and treatment modifications in 47 eyes of 46 patients with viral uveitis and its correlation with high intraocular pressure (HIOP), uveitis clinical characteristics and time intervals from samples to uveitis diagnosis and to relapse.

Results: CMV-PCR positive results occurred in 13 eyes (27. Read More

Medicine (Baltimore) 2017 Dec;96(51):e9288

Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.

Rationale: Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. Read More

Ocul Immunol Inflamm 2018 ;26(1):116-121

a Department of Ophthalmology , CHU Saint-Pierre, Université Libre de Bruxelles (ULB) , Brussels , Belgium.

Purpose: To evaluate diagnostic methods and clinical signs of CMV anterior uveitis (AU), a rarely described entity in Europe.

Methods: We included patients with clinical characteristics of CMV AU and positive PCR and/or Goldmann-Witmer coefficient (GWc) for CMV.

Results: We report 21 patients with unilateral uveitis (100%) and signs of Posner-Schlossman syndrome (PSS) (n = 20, 95. Read More

Ocul Immunol Inflamm 2018 27;26(1):107-115. Epub 2017 Nov 27.

f DHU ViewRestore , University of Pierre and Marie Curie, Sorbonne Universités , Paris , France.

Cytomegalovirus (CMV) anterior uveitis is the most common ocular manifestation of CMV disease in immunocompetent individuals. It is thought to be due to a local reactivation of latent CMV and is usually unilateral. The acute form presents as Posner-Schlossman Syndrome, a recurrent hypertensive anterior uveitis with few granulomatous keratic precipitates. Read More

Int J Ophthalmol 2017 18;10(10):1617-1619. Epub 2017 Oct 18.

Tianjin Medical University Eye Hospital, Tianjin 300384, China.

Ocul Immunol Inflamm 2018 13;26(1):104-106. Epub 2017 Oct 13.

a Department of Uveitis and Ocular Inflammation , Vittala International Institute of Ophthalmology & Prabha Eye Clinic and Research Center , Bangalore, India.

Purpose: To report an interesting case of development of tonic pupil in an immunocompetent male with cytomegalovirus (CMV) anterior uveitis.

Methods: Retrospective case report Results: A 30-year-old Iranian healthy male was diagnosed to have Posner-Schlossman syndrome (OS). Aqueous tap was positive for CMV by multiplex Polymerase chain reaction (PCR). Read More

Sci Rep 2017 08 29;7(1):9832. Epub 2017 Aug 29.

Department of Ophthalmology, Peking University Third Hospital Key Laboratory of Vision Loss and Restoration, Ministry of Education, No.49 North Garden Road, Haidian District, Beijing, China.

To investigate in vivo confocal microscopy (IVCM) findings in patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM findings from the eyes of patients with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 eyes); HLA-B27 anterior uveitis (B27AU) (45 eyes); and with acute attack of primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at the level of corneal basal epithelial cells of the PSS group (2.33 ± 0. Read More

HLA 2017 08 30;90(2):136-140. Epub 2017 May 30.

Key Laboratory of Shenzhen for Histocompatibility and Immunogenetics, Shenzhen Blood Center, Shenzhen, China.

A novel HLA-G allele, HLA-G*01:01:01:07, was identified in a Chinese patient with Posner-Schlossman syndrome. Read More

Clin Exp Ophthalmol 2017 12 13;45(9):925-927. Epub 2017 Jun 13.

Birmingham Institute for Glaucoma Research, Institute for Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Br J Ophthalmol 2017 12 27;101(12):1638-1642. Epub 2017 Apr 27.

The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China.

Aim: To describe the incidence of Posner-Schlossman syndrome (PSS) in Lucheng District, Wenzhou, China, over a 10-year period.

Methods: We reviewed retrospectively the medical records of all inpatient and outpatient patients diagnosed with PSS during the years 2005-2014 in the Eye Hospital of Wenzhou Medical University. The keywords of 'glaucomatocyclitic crisis', 'Posner-Schlossman syndrome' and 'PSS' were used for the retrieval. Read More

Ocul Immunol Inflamm 2018 27;26(1):90-93. Epub 2017 Apr 27.

a Ocular Inflammation and Immunology Service , Singapore National Eye Centre , Singapore.

Cytomegalovirus (CMV) anterior uveitis and endotheliitis occurs among immunocompetent individuals and may manifest as Posner-Schlossman syndrome or Fuchs uveitis syndrome. The condition may first present following ophthalmic surgery, the use of a fluocinolone-sustained steroid drug delivery implant, or the use of topical prostaglandin analogues for the treatment of glaucoma. We report the first case of a non-human immunodeficiency virus-infected individual who presented with CMV anterior uveitis after the use of topical cyclosporine A 0. Read More

J Ocul Pharmacol Ther 2017 05 20;33(4):313-318. Epub 2017 Apr 20.

1 Department of Ophthalmology, Saint Pierre Hospital , Université Libre de Bruxelles, Brussels, Belgium .

Purpose: To study the effects of topical ganciclovir 0.15% gel on cytomegalovirus (CMV) anterior uveitis in a tertiary uveitis referral center in Brussels, Belgium.

Methods: A retrospective study of patients with a clinical diagnosis of CMV anterior uveitis/endotheliitis demonstrated by a positive polymerase chain reaction and/or Goldmann-Witmer coefficient (GWc). Read More

BMC Ophthalmol 2017 Apr 11;17(1):45. Epub 2017 Apr 11.

Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner-Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. Read More

PLoS One 2017 6;12(4):e0175519. Epub 2017 Apr 6.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America.

Posner-Schlossman syndrome (PSS) shares some clinical features with uveitis and open angle glaucoma. Cytokines and autoantibodies have been associated with uveitis and open angle glaucoma. However, the role of serum cytokines and autoantibodies in the pathogenesis of PSS remains unknown. Read More

Zhonghua Yan Ke Za Zhi 2017 Feb;53(2):104-108

Eye & ENT Hospital, Shanghai Medical College of Fudan University, Shanghai 200031, China.

To evaluate the usefulness of albumin correction in determination of cytomegalovirus IgG in the aqueous humor of Posner-Schlossman syndrome (PSS) patients. Cases series studies. Forty-two patients (26 men and 16 women) who were diagnosed as PSS were enrolled from Oct. Read More

Surv Ophthalmol 2017 May - Jun;62(3):277-285. Epub 2016 Dec 22.

Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom.

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of nongranulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males. Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Read More

J Glaucoma 2017 Mar;26(3):247-252

*Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand †Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: The aim of this study was to report on the prevalence of uveitic secondary glaucoma (USG) and ocular hypertension in patients with uveitis in Thailand, and to identify factors associated with the development of USG and its visual outcome.

Design: This is a retrospective cohort study.

Methods: We included 174 consecutive uveitis patients (237 affected eyes) visiting the Ophthalmology Department of Chiang Mai University Hospital, Thailand, from January 2013 to March 2013. Read More

Ocul Immunol Inflamm 2017 27;25(sup1):S31-S38. Epub 2016 Jul 27.

a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan and.

Purpose: To analyze the patterns and etiologies of uveitis at a tertiary referral center in Taiwan.

Methods: This retrospective chart review of uveitis patients from January 2001 to December 2014 updates a previous study a decade ago (2003).

Results: We identified 450 patients, among whom anterior uveitis was most common, followed by panuveitis, posterior uveitis, and intermediate uveitis. Read More

Eye (Lond) 2016 Jun 8;30(6):865-72. Epub 2016 Apr 8.

Medical Retina and Uveitis Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

PurposeTo develop and validate a Bayesian belief network algorithm for the differential diagnosis of anterior uveitis.Patients and methodsThe 11 most common etiologies were included (idiopathic, ankylosing spondylitis, psoriasic arthritis, reactive arthritis, inflammatory bowel diseases, sarcoidosis, tuberculosis, Behçet, Posner-Schlossman syndrome, juvenile idiopathic arthritis (JIA), and Fuchs' heterochromic cyclitis). Frequencies of association between factors and etiologies were retrieved from a systematic review of the literature. Read More

Ocul Immunol Inflamm 2017 8;25(sup1):S8-S14. Epub 2016 Mar 8.

b Department of Ophthalmology , Japan Community Healthcare Organization Tokyo Shinjuku Medical Center , Shinjuku-ku , Tokyo , Japan.

Purpose: To investigate the frequency of conditions of newly arrived patients with uveitis from 2010 to 2012 and compare this frequency with that since 2004.

Methods: We retrospectively analyzed clinical records of patients who visited the outpatient clinic from January 2010 to December 2012, and compared them with those from 2004-2009.

Results: From 2010 to 2012, 695 new patients with uveitis visited Tokyo University Hospital, with a definite diagnosis made in 431 (62. Read More

PLoS One 2015 10;10(7):e0132179. Epub 2015 Jul 10.

Immunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, Guangdong, People's Republic of China.

The etiology of Posner-Schlossman syndrome (PSS) remains unknown. The association of human leukocyte antigens (HLA) allelic diversity with PSS has been poorly investigated. To evaluate the association of allelic polymorphisms of class I HLA-A, -B and -C and class II HLA-DRB1 and -DQB1 with PSS, 100 unrelated patients with PSS and 128 age- and ethnically matched control subjects were recruited from a southern Chinese Han population. Read More

Eye (Lond) 2015 Oct 3;29(10):1335-9. Epub 2015 Jul 3.

Department of ophthalmology, Campus Virchow clinic, Charite University medicine, Berlin, Germany.

Purpose: To assess the outcome of trabectome surgery in the treatment of glaucomatocyclitic crisis (Posner-Schlossman syndrome) in patients with uncontrolled intraocular pressure (IOP).

Patients/methods: Trabectome surgery was performed in seven patients with diagnosed glaucomatocyclitic crisis and uncontrolled IOP where cytomegalovirus DNA was verified by polymerase chain reaction in aqueous humour samples. All patients were treated with oral valganciclovir. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2015 Apr;32(2):254-8

Shenzhen Eye Hospital Affiliated to Jinan University, Shenzhen, Guangdong 518040, P.R.China.

Objective: To assess the association of HLA-DPA1 and -DPB1 polymorphisms with Posner-Schlossman syndrome (PSS) in southern Chinese Han population.

Methods: A total of 100 randomly selected PSS patients of southern Chinese Han origin were served as the experimental group, while 128 unrelated healthy blood donors of the same origin were served as the control group. All samples were subjected to sequencing-based typing (SBT) for exon 2 of HLA-DPA1 and -DPB1 loci in both directions. Read More

Taiwan J Ophthalmol 2015 Apr-Jun;5(2):90-93. Epub 2015 Feb 17.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

A 30-year-old man presented with glaucomatocyclitic crisis, also known as Posner-Schlossman syndrome, and acute intraocular pressure elevation. Changes in the longitudinal retinal nerve fiber layer (RNFL) and the cup-to-disc (C/D) ratio of the optic disc were detected by Stratus optical coherence tomography (OCT). The average RNFL thickness in the affected eye was greater than that in the unaffected eye on Day 3 (132. Read More

BMJ Case Rep 2015 Jan 23;2015. Epub 2015 Jan 23.

Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.

The Posner-Schlossman syndrome (PSS) is an elusive disease that can lead to serious consequences such as glaucomatous damage. Deep sclerectomy has been proven thus far to be the most effective surgical intervention to keep intraocular pressure (IOP) elevation under control compared with other surgical techniques, because it presents the least amount of postoperative complications. The aim of this case report is to demonstrate the efficacy of deep sclerectomy with T-Flux and the long-lasting effects that persist after 7 years in an eye affected by PSS. Read More

Clin Ophthalmol 2014 26;8:2383-9. Epub 2014 Nov 26.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments.

Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. Read More

Ocul Immunol Inflamm 2015 10;23(5):378-83. Epub 2014 Sep 10.

b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.

Purpose: To present the clinical characteristics of patients with anterior uveitis who had evidence of cytomegalovirus (CMV) infection on polymerase chain reaction PCR-based assays for viral DNA in aqueous samples.

Methods: This was a retrospective observational case series of 16 patients with CMV infection on qualitative polymerase chain reaction PCR-based assays for viral DNA in aqueous samples. Case records of 16 patients were reviewed and relevant clinical information was collected using a standardized data sheet. Read More

Ocul Immunol Inflamm 2015 Aug 25;23(4):291-296. Epub 2014 Aug 25.

a Department of Ophthalmology , University of Tokyo Graduate School of Medicine , Hongo, Bunkyo-ku , Tokyo , Japan and.

Purpose: To investigate the frequencies of the diseases in the new patients with uveitis during 2007-2009 and compare them with previously-reported data from the University of Tokyo Hospital.

Methods: We retrospectively analyzed the clinical records of patients who visited the outpatient clinic from January 2007 to December 2009, and compared them with those of 1963-2006.

Results: During 2007-2009, 468 new patients visited our hospital. Read More

Graefes Arch Clin Exp Ophthalmol 2014 Nov 20;252(11):1817-24. Epub 2014 Aug 20.

Servizio di Immunovirologia Oculare, Sapienza Università di Roma, Viale del Policlinico 155, 00167, Rome, Italy,

Background: We aimed to report on the clinical findings and long-term prognosis of patients with cytomegalovirus (CMV) anterior uveitis.

Methods: This was a retrospective observational study on 15 immunocompetent patients with CMV anterior uveitis and a follow-up longer than 24 months (mean: 62.1 ± 28. Read More

Am J Ophthalmol 2014 Nov 12;158(5):1024-1031.e2. Epub 2014 Aug 12.

Department of Ophthalmology, National Taiwan University Hospital College of Medicine, National Taiwan University, Taipei, Taiwan; National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. Electronic address:

Purpose: To evaluate the clinical characteristics and therapeutic outcomes of cytomegalovirus (CMV)-positive Posner-Schlossman syndrome patients undergoing topical ganciclovir treatment.

Design: Retrospective, comparative, and interventional case series.

Methods: One eye of each of 126 consecutive Posner-Schlossman syndrome patients was investigated using aqueous polymerase chain reaction (PCR) between January 2006 and June 2013. Read More

Korean J Anesthesiol 2014 Mar 28;66(3):248-51. Epub 2014 Mar 28.

Department of Anaesthesia, Intensive Care and Pain Management, Axon Anaesthesia Associates, Global Hospitals, Hyderabad, India.

A 56-year-old man with a rotator cuff injury, scheduled for arthroscopic reconstruction surgery, had a history of recurrent symptoms of eyeball pain and blurred vision for several years. After close examination, he was diagnosed with Posner-Schlossman syndrome. Three weeks before the scheduled surgery, his intraocular pressure (IOP) increased (> 30 mmHg) and he became extremely anxious about the surgery. Read More

Br J Ophthalmol 2014 Jul 28;98(7):932-6. Epub 2014 Mar 28.

Department of Ophthalmology, National Defense Medical College.

Aims: To evaluate the prevalence and aetiology of intraocular hypertension (OHT) in granulomatous and non-granulomatous uveitis

Methods: Medical records of 304 consecutive patients (484 eyes) with uveitis who visited the National Defense Medical Collage Hospital between April 2010 and March 2013 were reviewed retrospectively. OHT irrelevant to glaucomatous changes in optic disc or visual field was investigated.

Results: OHT was found in 123 eyes (25. Read More

Int Ophthalmol 2014 Oct 13;34(5):1123-9. Epub 2014 Mar 13.

Noor Ophthalmic Research Center, Noor Eye Hospital, Tehran, Iran,

To describe clinical features, laboratory findings, course of disease and response to treatment in four patients diagnosed with Posner-Schlossman syndrome (PSS) who had evidence of cytomegalovirus (CMV) infection in their aqueous humour. Review of four consecutive CMV positive PSS patients seen at the Noor Eye Hospital. CMV was diagnosed by polymerase chain reaction analysis of their aqueous. Read More

Graefes Arch Clin Exp Ophthalmol 2014 Jan 28;252(1):117-24. Epub 2013 Nov 28.

Center for Ophthalmology, Eberhard-Karls University Tuebingen, Tuebingen, Germany,

Background: To assess the short-term and long-term efficacy of oral therapy with valganciclovir in patients with Posner-Schlossman Syndrome (PSS).

Methods: This is a retrospective observational study on 11 patients with PSS treated with valganciclovir. The PSS was diagnosed clinically on the basis of recurrent episodes of anterior uveitis associated with attacks of elevated intraocular pressure (IOP). Read More

Int J Ophthalmol 2013 18;6(2):246-50. Epub 2013 Apr 18.

Department of Ophthalmology, Royal Bolton Hospital Foundation Trust, Bolton, BL4 0JR, United Kingdom.

Aim: To analyse previous literature and to formulate a management strategy for iris microhaemangiomas (IMH).

Methods: A review of the literature in English language articles on IMH.

Results: Thirty five English language articles fulfilled the criteria for inclusion to the study and based on the contents on these articles a management strategy was formulated. Read More

Korean J Ophthalmol 2012 Dec 12;26(6):473-7. Epub 2012 Nov 12.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

A 32-year-old man with blurred vision in the right eye and headache presented with anterior uveitis, an intraocular pressure (IOP) of 60 mmHg, an open angle, no visual field defects, and normal optic nerve. He had a history of five previous similar attacks. In each of the previous instances, his anterior uveitis and high IOP were controlled with antiglaucoma medications and topical steroids. Read More

PLoS One 2012 13;7(9):e44453. Epub 2012 Sep 13.

Department of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Aim: To study the differences in aqueous cytokines in Posner-Schlossman Syndrome (PSS) patients with and without human cytomegalovirus (CMV) DNA in the aqueous humor.

Methods: This is a prospective study. Fifty-three uveitis patients with clinical signs of PSS were enrolled and aqueous humor samples were collected. Read More

J Glaucoma 2014 Feb;23(2):88-94

*Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto †Department of Ophthalmology, Faculty of Medicine, Saga University, Saga ‡Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui §Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.

Purpose: To elucidate the long-term outcomes and prognostic factors for trabeculectomy with mitomycin C (MMC) in eyes with uveitic glaucoma (UG).

Methods: A retrospective, consecutive, comparative cohort study was conducted with 204 patients who underwent trabeculectomy with MMC between 1999 and 2008 at 2 Japanese clinical centers. The study group included 101 eyes with UG and 103 eyes with primary open-angle glaucoma (POAG). Read More

Jpn J Ophthalmol 2012 Sep 3;56(5):432-5. Epub 2012 Jul 3.

Japanese Ocular Inflammation Society, Tokyo, Japan.

Purpose: To investigate etiologic data on intraocular inflammation in Japan collected in the 2009 epidemiologic survey of uveitis in Japan and assess the current state of etiology compared with that reported in a previous survey.

Methods: Thirty-six university hospitals participated in this prospective etiologic study. Patients who visited the outpatient uveitis clinic of each hospital for the first time between 1 June 2009 and 31 May 2010 were enrolled in the study. Read More

Eye (Lond) 2012 Apr 13;26(4):529-34. Epub 2012 Jan 13.

Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Aims: To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU).

Methods: Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by real-time polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Read More