7,309 results match your criteria Portal Vein Thrombosis


CON: Anticoagulation for Portal Vein Thrombosis in Advanced Cirrhosis.

Clin Liver Dis (Hoboken) 2018 Sep 2;12(3):80-82. Epub 2018 Oct 2.

University of Minnesota Minneapolis MN.

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http://dx.doi.org/10.1002/cld.713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385912PMC
September 2018

PRO: Patients With Advanced Cirrhosis and Portal Vein Thrombosis Should Receive Anticoagulation.

Clin Liver Dis (Hoboken) 2018 Sep 2;12(3):74-79. Epub 2018 Oct 2.

Digestive Diseases Section, Department of Medicine Yale University New Haven CT.

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http://dx.doi.org/10.1002/cld.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385918PMC
September 2018

The inhibitory role of recombinant P-selectin glycoprotein ligand immunoglobulin G on portal vein thrombosis based on a novel rat model.

Exp Ther Med 2019 May 13;17(5):3589-3597. Epub 2019 Mar 13.

Department of Gastrointestinal Surgery, Huzhou Central Hospital, Zhejiang University Huzhou Hospital, Huzhou, Zhejiang 313000, P.R. China.

The current study aimed to reveal a novel method for constructing a portal vein thrombosis (PVT) model in rats and to evaluate the inhibitory role of recombinant P-selectin glycoprotein ligand immunoglobulin G (rPSGL-Ig) on the formation of PVT. The PVT model was constructed in rats through intermittent portal vein obstruction (IPVO) combined with endangium destruction. A total of 4 mg/kg rPSGL-Ig was intraperitoneally pre-injected into rats 1 h prior to model construction. Read More

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http://dx.doi.org/10.3892/etm.2019.7394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447773PMC

Acupuncture for perioperative care of total hip arthroplasty: A systemic review of controlled trials and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(15):e15198

Department of Korean Medicine Rehabilitation.

Introduction: This protocol is intended to conduct a systematic review and meta-analysis to evaluate the efficacy and safety of acupuncture in perioperative care of total hip arthroplasty patients.

Methods And Analysis: The following databases will be searched from their inception to November 2018 without language restrictions: MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature, Oriental Medicine Advanced Searching Integrated System, Korean Traditional Knowledge Portal, KoreaMed, DBPIA, Research Information Service System, including the China National Knowledge Infrastructure. Any randomized controlled trials related to perioperative care of total hip arthroplasty will be included. Read More

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http://dx.doi.org/10.1097/MD.0000000000015198DOI Listing

Direct-Acting Oral Anticoagulants (DOACs) in Cirrhosis and Cirrhosis-Associated Portal Vein Thrombosis.

Semin Liver Dis 2019 Apr 12. Epub 2019 Apr 12.

Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Direct-acting oral anticoagulants (DOACs) have provided benefit in patients requiring anticoagulation for certain diseases by decreasing the burden of subcutaneous injections and the requirement for frequent monitoring through regular blood tests, to ensure adequacy of the therapeutic doses. Studies have demonstrated DOACs to be as safe, and in some instance safer, compared with traditional anticoagulants in the general population. However, the studies evaluating DOACs excluded patients with cirrhosis, a condition associated with an increased risk of developing portal vein thrombosis (PVT). Read More

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http://dx.doi.org/10.1055/s-0039-1679934DOI Listing
April 2019
1 Read

Splenectomy following JAK1/JAK2 inhibitor therapy in patients with myelofibrosis undergoing allogeneic stem cell transplantation.

Hematol Oncol Stem Cell Ther 2019 Apr 6. Epub 2019 Apr 6.

Raisa Gorbacheva Memorial Research Institute of Children Oncology, Hematology and Transplantation, Department of Hematology, Transfusiology, Transplantation, Faculty of Postgraduate Education, Pavlov First Saint Petersburg State Medical University, Saint-Petersburg, Russia.

Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only treatment option with curative potential in patients with myelofibrosis (MF). The aim of our study was to evaluate the safety of splenectomy before alloHSCT in MF patients who failed to achieve significant spleen response after ruxolitinib therapy.

Methods: Splenectomy was performed in 12 patients for alloHSCT with myelofibrosis-primary (6 patients), post-polycythemia vera (3 patients). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16583876193002
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http://dx.doi.org/10.1016/j.hemonc.2019.03.001DOI Listing
April 2019
4 Reads

Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single-Center, Clinical Experience in 105 Patients.

Hepatol Commun 2019 Apr 5;3(4):513-524. Epub 2019 Feb 5.

Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital London United Kingdom.

Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternative because they are more readily available and avoid large-volume transfusion. This retrospective, single-center study reviewed clinical use of PCC in patients with acute/chronic liver disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep4.1293
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http://dx.doi.org/10.1002/hep4.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442702PMC
April 2019
8 Reads

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis.

Hepatol Commun 2019 Apr 2;3(4):504-512. Epub 2019 Mar 2.

Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy.

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. Read More

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http://doi.wiley.com/10.1002/hep4.1317
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http://dx.doi.org/10.1002/hep4.1317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442692PMC
April 2019
4 Reads

Pelvic lipomatosis associated with portal vein thrombosis and hydronephrosis: a case report.

Authors:
Özkacmaz Sercan

J Int Med Res 2019 Apr 10:300060519840912. Epub 2019 Apr 10.

Kırşehir Ahi Evran University, Kırşehir, Turkey.

Pelvic lipomatosis is an uncommon disease with no clear etiology and it occurs secondary to deposition of a large amount of fatty tissue in the pelvis. This deposition causes compression to the rectum, bladder, and venous structures. Because of this compression, various symptoms, such as recurrent urinary infections, dysuria, tenesmus, and constipation, have mostly been reported. Read More

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http://dx.doi.org/10.1177/0300060519840912DOI Listing
April 2019
2 Reads

Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B in Korea (KROG 16-05).

Cancer Res Treat 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Purpose: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal RT in HCC patients with CP-B.

Materials And Methods: We retrospectively reviewed the data of HCC patients with CP-B treated with RT between 2009 and 2014 at 13 institutions in Korea. Read More

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http://dx.doi.org/10.4143/crt.2018.687DOI Listing
April 2019
1 Read
2.975 Impact Factor

Porta hepatis abscess and portal vein thrombosis following ingestion of a fishbone.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Division of General Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

A man in his late 50s presented to the emergency room with a 1-month history of severe abdominal pain and an endoscopic fishbone retrieval from his rectum. Serial CT scans revealed a fishbone located in the patient's upper abdomen, which had migrated through the stomach wall, into the periportal space, causing a contained gastric perforation, development of a porta hepatis abscess and secondary portal vein thrombosis. Furthermore, the sharp tip of the fishbone lay 5 mm from the patient's hepatic artery. Read More

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http://dx.doi.org/10.1136/bcr-2018-227271DOI Listing

Porto-sinusoidal vascular disease: proposal and description of a novel entity.

Lancet Gastroenterol Hepatol 2019 May;4(5):399-411

Barcelona Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain; CIBER Hepatic and Digestive Diseases, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Portal hypertension in the absence of portal vein thrombosis and without cirrhosis, but with mild or moderate alterations of liver histology (eg, obliterative venopathy, nodular regenerative hyperplasia, or incomplete septal cirrhosis) is being increasingly recognised. Owing to the heterogeneity of causes and histological findings, a substantial number of terms have been used to describe such idiopathic non-cirrhotic portal hypertension. Patients with the same clinical and histological features exist, but without portal hypertension at the time of diagnosis. Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30047-0DOI Listing
May 2019
1 Read

Hepatic disorders associated with exogenous sex steroids: MR imaging findings.

Abdom Radiol (NY) 2019 Apr 6. Epub 2019 Apr 6.

Monash Imaging, Monash Health, Melbourne, Australia.

Objective: To describe the MRI findings of the effects of exogenous sex steroids on the liver.

Findings: Estrogens, progesterone and synthetic testosterone are exogenous sex steroids that may result in a variety of liver diseases, including tumour formation and vascular disorders. These hormones are mainly administered in the form of the oral contraceptive pill (OCP) and anabolic steroids. Read More

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http://dx.doi.org/10.1007/s00261-019-01941-4DOI Listing
April 2019
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Y-Loaded Microsphere SIRT of HCC Patients With Portal Vein Thrombosis: High Clinical Impact of 99mTc-MAA SPECT/CT-Based Dosimetry.

Semin Nucl Med 2019 May 7;49(3):218-226. Epub 2019 Feb 7.

Cancer Institute Eugène Marquis, Department of Nuclear Medicine, Rennes, France; Univ Rennes, INSERM, INRA, Centre de Lutte contre le Cancer Eugène Marquis, Institut NUMECAN (Nutrition Metabolisms and Cancer), Rennes, France.

Radioembolization with Y-loaded microspheres based on classical prescription methods is increasingly applied to hepatocellular carcinoma (HCC) patients with portal vein thrombosis (PVT). In recent years, pretherapeutic predictive dosimetry based on technetium-99m macroaggregated albumin (MAA) quantitative scintigraphy using SPECT/CT has been developed. This paper presents an overview on the MAA-based dosimetry concept, discusses important confounding factors, such segmentation methods, and specific angiographic considerations required for a simulation-based dosimetric evaluation. Read More

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http://dx.doi.org/10.1053/j.semnuclmed.2019.01.006DOI Listing

Five-year Recurrence-free Survival After Surgery Followed by Oral Chemotherapy for Gastric Cancer With Portal Vein Tumor Thrombosis.

Anticancer Res 2019 Apr;39(4):2233-2238

Department of Surgery, Kumamoto Chuo hospital, Kumamoto, Japan.

Gastric cancer with portal vein tumor thrombosis (GC-PVTT) is a rare condition with a very poor prognosis. A 64-year-old man with GC-PVTT was admitted to our hospital. His carcinoembryonic antigen level was slightly elevated (17. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13339DOI Listing
April 2019
2 Reads

HEP-18-0797.R2 - Liver Stiffness Measurements in Patients with Non-cirrhotic Portal Hypertension - The Devil is In the Details.

Hepatology 2019 Apr 5. Epub 2019 Apr 5.

Indiana University, Medicine.

We appreciate the interest and the thoughtful response by Gioia et al. on our recent observations about the liver stiffness measurement in patients with non-cirrhotic portal hypertension (NCPH). The causes of NCPH are myriad and can be prehepatic, hepatic or post hepatic. Read More

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http://dx.doi.org/10.1002/hep.30640DOI Listing
April 2019
2 Reads

Portal vein leiomyosarcoma: A rare case of hepatic hilar tumor with review of the literature.

Indian J Cancer 2019 Jan-Mar;56(1):83-85

Department of Hepatobiliary and Digestive Surgery, CHU Rennes; Univ Rennes, CIC 1414 (Centre d'Investigation Clinique de Rennes), F-35000 Rennes, France.

Portal vein leiomyosarcoma (LMS) is a very rare entity with poor prognosis. Only few cases have been reported in the literature. We report the case of a 53-year-old man with portal vein LMS presenting as a hilar tumor and causing cholestasis. Read More

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http://dx.doi.org/10.4103/ijc.IJC_199_18DOI Listing
April 2019
1 Read

Liver Abscess in a Pediatric Patient with Ulcerative Colitis: A Case Presentation.

J Clin Transl Hepatol 2019 Mar 4;7(1):93-96. Epub 2019 Mar 4.

Department of Pediatric Gastroenterology, Atrium Health- Levine Children's Hospital, Charlotte, NC, USA.

Hepatic abscesses are an uncommon extra-intestinal manifestation of inflammatory bowel disease, the incidence of which has been estimated to be approximately 7 per 10,000 patients with inflammatory bowel disease. It is unclear whether patients with Crohn's disease or patients with ulcerative colitis (UC) are at higher risk of developing this complication. Based on case reports, most cases are found in Crohn's disease; however, a recent cohort study showed an increased risk in UC instead. Read More

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http://dx.doi.org/10.14218/JCTH.2018.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441647PMC
March 2019
3 Reads

Sorafenib alone vs. sorafenib plus GEMOX as 1-line treatment for advanced HCC: the phase II randomised PRODIGE 10 trial.

Br J Cancer 2019 Apr 4. Epub 2019 Apr 4.

Gustave Roussy, Villejuif, France.

Background: Sorafenib remains one major first-line therapeutic options for advanced hepatocellular carcinoma (aHCC), with modest efficacy. We investigated the addition of gemcitabine and oxaliplatin (GEMOX) to sorafenib in aHCC patients.

Methods: Our multicentre phase II trial randomised aHCC first-line patients to sorafenib (400 mg BID) or sorafenib-GEMOX every 2 weeks (1000 mg/m gemcitabine; 100 mg/m oxaliplatin). Read More

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http://www.nature.com/articles/s41416-019-0443-4
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http://dx.doi.org/10.1038/s41416-019-0443-4DOI Listing
April 2019
5 Reads

Portal Vein Thrombosis in Decompensated Cirrhosis: Rationale for Treatment.

Clin Transl Gastroenterol 2019 Apr 2. Epub 2019 Apr 2.

Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.

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http://dx.doi.org/10.14309/ctg.0000000000000026DOI Listing

The risk factors of portal vein thrombosis in patients with liver cirrhosis.

Exp Ther Med 2019 Apr 22;17(4):3189-3194. Epub 2019 Feb 22.

Department of Gastroenterology, Medical Faculty, Inonu University, 44280 Malatya, Turkey.

This study was designed to identify and assess risk factors for portal vein thrombosis (PVT) in patients with cirrhosis. A total of 98 cirrhosis patients with PVT were identified and 101 cirrhosis patients without PVT were chosen as the control group in this retrospective study. Several variables were measured and the two groups PVT and non-PVT were compared statistically. Read More

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http://dx.doi.org/10.3892/etm.2019.7300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434378PMC
April 2019
1 Read

Successful recanalization of acute extensive portal vein thrombosis by aspiration thrombectomy and thrombolysis via an operatively placed mesenteric catheter: a case report.

BJR Case Rep 2018 Dec 21;4(4):20180024. Epub 2018 May 21.

Department of Radiology, Tokyo Medical University Hospital, Tokyo, Japan.

Portal vein thrombosis (PVT) after hepatobiliary surgery is rare but can cause lethal and severe complications. If early diagnosis and recanalization can be achieved, the PVT is expected to be eliminated. A 70-year-old male was diagnosed as having hepatocellular carcinoma occupying the right lobe of the liver. Read More

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http://dx.doi.org/10.1259/bjrcr.20180022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438407PMC
December 2018
1 Read

Etiology, presenting features and outcome of children with non-cirrhotic portal vein thrombosis: A multicentre national study.

Dig Liver Dis 2019 Mar 6. Epub 2019 Mar 6.

Paediatric Liver, GI and Transplantation, Hospital Papa Giovanni XXIII Bergamo, Bergamo, Italy. Electronic address:

Objectives: Non-cirrhotic portal vein thrombosis (PVT) is a main cause of portal hypertension in children. We describe the characteristics at presentation and outcome of a cohort of patients with PVT to determine clinical features and predictors of outcome.

Methods: We recorded: (1) Associated factors: prematurity, congenital malformations, neonatal illnesses, umbilical vein catheterization (UVC), deep infections, surgery; (2) congenital and acquired prothrombotic disorders; (3) features at last follow up including survival rate and need for surgery. Read More

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http://dx.doi.org/10.1016/j.dld.2019.02.014DOI Listing
March 2019
1 Read

High-density lipoprotein cholesterol for the prediction of mortality in cirrhosis with portal vein thrombosis: a retrospective study.

Lipids Health Dis 2019 Mar 30;18(1):79. Epub 2019 Mar 30.

Department of Gastroenterology and Clinical Nutrition, Nanjing Medical University Drum Tower Clinical Medical School, 321zhongshan road, Gulou District, Nanjing, 210008, China.

Background: Lipid profiles disorders frequently occur in patients with chronic liver diseases, and the mortality of cirrhosis complicated with portal vein thrombosis (PVT) remains high. Research identifying simple and objective prognosis indicators for cirrhotic PVT has been limited. The aim of the present study was to investigate the association between lipid profiles and liver function, which may help predict the 1-year mortality in non-malignant cirrhosis with PVT. Read More

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http://dx.doi.org/10.1186/s12944-019-1005-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441144PMC
March 2019
1 Read
2.219 Impact Factor

Abdominal surgery in patients with idiopathic noncirrhotic portal hypertension: a multicenter retrospective study.

Hepatology 2019 Mar 29. Epub 2019 Mar 29.

Service d'Hépatologie, Centre de Référence des Maladies Vasculaires du Foie, DHU Unity, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon, AP-HP, Clichy, France.

In patients with idiopathic noncirrhotic portal hypertension (INCPH), data on morbi-mortality of abdominal surgery are scarce We retrospectively analyzed the charts of patients with INCPH undergoing abdominal surgery within the VALDIG network. Forty-four patients with biopsy-proven INCPH were included. Twenty-five (57%) patients had ≥1 extrahepatic conditions related with INCPH and 16 (36%) had a history of ascites. Read More

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http://dx.doi.org/10.1002/hep.30628DOI Listing
March 2019
1 Read

The prognosis of bulky hepatocellular carcinoma with nonmajor branch portal vein tumor thrombosis.

Medicine (Baltimore) 2019 Mar;98(13):e15066

Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung.

A bulky, solitary hepatocellular carcinoma (HCC) with nonmajor branch portal vein tumor thrombosis (PVTT) was staged as T2 in the tumor-node-metastasis (TNM) system. We aimed to evaluate the prognosis of this group of patients.A total of 2643 patients with HCC in a medical center were consecutively enrolled. Read More

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http://dx.doi.org/10.1097/MD.0000000000015066DOI Listing

Contrast-enhanced ultrasonography - An indispensable tool in the hands of any hepatologist.

Rev Esp Enferm Dig 2019 Mar 28;111. Epub 2019 Mar 28.

Digestivo, Complejo Hospitalario de Toledo, España.

Vascular complications after liver transplantation may lead to graft dysfunction and liver failure, which in turn results in need for retransplantation and death risk. Therefore, their early diagnosis is critical. Major vascular complications include hepatic artery thrombosis, stenosis and aneurysms; portal vein thrombosis and stenosis; and potential additional complications in hepatic veins and vena cava. Read More

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http://dx.doi.org/10.17235/reed.2019.6240/2019DOI Listing

[ELABORATION AND TREATMENT DECISION IN INCIDENTAL SPLANCHNIC VEIN THROMBOSIS].

Harefuah 2019 Mar;158(3):176-179

Liver Unit of Clalit Medical Services - Haifa and Western, Galilee region.

Introduction: In the present article, a patient with incidental findings in computerized tomography (CT) of cavernous transformation of the splanchnic veins, thrombosis of the splenic and portal veins, esophagus and gastric varicose veins and splenomegaly is presented. The CT was performed due to mild chronic normocytic anemia known for two years and the elevated level of LDH (Lactic dehydrogenase). Although usually such incidental findings without cirrhosis do not necessitate anticoagulation therapy according to the literature, in cases of myeloproliferative diseases, anticoagulation is required in order to prevent thrombus propagation. Read More

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March 2019
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[A twenty-year review of clinical liver transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Mar;31(3):269-280

Organ Transplantation Center, Tianjin First Center Hospital, Tianjin Clinical Medical Research Center for Organ Transplantation, Key Laboratory of National Health Commission for Critical Care and Emergency Medicine, Key Laboratory of Chinese Academy of Medical Sciences for Organ Transplantation, Tianjin Key Laboratory for Organ Transplantation, Tianjin 300192, China.

Objective: To review the development of adult and pediatric liver transplantation in Tianjin First Center Hospital, and to enhance academic exchanges, improve technological innovation, and jointly promote the progress and maturity in the field of liver transplantation.

Methods: The development of liver transplantation in Tianjin First Center Hospital was analyzed. The clinical data of adult and pediatric liver transplantation from September 1998 to September 2018 were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.03.004DOI Listing
March 2019
6 Reads

Antegrade hepatic artery and portal vein perfusion versus portal vein perfusion alone in live donor liver transplantation: a randomized trial.

Liver Transpl 2019 Mar 25. Epub 2019 Mar 25.

Department of Gastrointestinal Surgery & Solid Organ Transplant, Amrita Institute of Medical Sciences & Research Centre, Amrita University, Kochi, Kerala, India, 682041.

Background: Traditionally, deceased donor liver grafts receive dual perfusion through the portal vein and the hepatic artery(HA) either in-situ or on the back-table. Hepatic artery perfusion is avoided in live donor liver grafts for fear of damage to the intima and consequent risk of hepatic artery thrombosis(HAT). However, biliary vasculature is predominantly derived from the HA. Read More

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http://dx.doi.org/10.1002/lt.25455DOI Listing

All about portal vein: a pictorial display to anatomy, variants and physiopathology.

Insights Imaging 2019 Mar 21;10(1):38. Epub 2019 Mar 21.

Medical Imaging Department, Coimbra Hospital and University Centre, Coimbra, Portugal.

The portal vein (PV) is the main vessel of the portal venous system (PVS), which drains the blood from the gastrointestinal tract, gallbladder, pancreas, and spleen to the liver. There are several variants affecting the PV, and quite a number of congenital and acquired pathologies.In this pictorial review, we assess the embryological development and normal anatomy of the PVS, displaying selected cases consisting of normal variants, congenital anomalies, and a large and heterogeneous group of acquired conditions that may affect the PV. Read More

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http://dx.doi.org/10.1186/s13244-019-0716-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428891PMC
March 2019
2 Reads

Short-term and long-term outcomes of liver resection for HCC patients with portal vein tumor thrombus.

Cell Biosci 2019 6;9:23. Epub 2019 Mar 6.

1Department of Hepatic Surgery IV, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Shanghai, 200433 China.

Background: Portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) is a sign of advanced stage disease, which is associated with poor prognosis. Liver resection (LR) may provide better prognosis in selected patients. In the present study, we aimed to assess information from HCC patients with PVTT who died within 3 months or 2 years after LR in order to identify preoperative factors correlated to short-term or long-term survival, by which inappropriate selection of patients for LR might be avoided in the future. Read More

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http://dx.doi.org/10.1186/s13578-019-0285-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404349PMC
March 2019
1 Read

How to identify better candidate to radioembolization in case of hepatocellular carcinoma and portal vein tumoral thrombosis.

Hepatobiliary Surg Nutr 2019 Feb;8(1):63-64

Service de Chirurgie Hépatobiliaire et Digestive, CHU Rennes, Rennes, France.

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http://dx.doi.org/10.21037/hbsn.2018.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383006PMC
February 2019

Vascular Complications After Liver Transplantation.

Exp Clin Transplant 2019 Mar 14. Epub 2019 Mar 14.

From the Department of General Surgery, Hepatopancreaticobiliary Surgery and Liver Transplantation Unit, Dokuz Eylul University Faculty of Medicine, Narlıdere, Izmir, Turkey.

Objectives: Vascular complications after liver trans-plant can be lethal. High levels of suspicion and aggressive use of diagnostic tools may help with early diagnosis and treatment. Here, we share our experiences regarding this topic. Read More

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http://dx.doi.org/10.6002/ect.2018.0240DOI Listing
March 2019
1 Read

Response to the article "Perioperative standards for the treatment of coagulation disorders and usage of blood products in patients undergoing liver transplantation used in the Clinic for Transplant Surgery in Wrocław".

Adv Clin Exp Med 2019 Mar;28(3):415-416

Department of Anesthesiology and Intensive Care, Medical University of Warsaw, Poland.

We read with interest the article by Łukaszewski et al. published in Advances in Clinical and Experimental Medicine:1211-1215, published online on July 18th, 2018, as ahead of print). As enthusiasts of promoting global assays of hemostasis, we would like to commend the authors for their commitment and effort in their implementation and clinical application. Read More

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http://dx.doi.org/10.17219/acem/104539DOI Listing
March 2019
1 Read

Disseminated phaeohyphomycosis with hepatic artery and portal vein thrombosis caused by Pleurostomophora richardsiae in a liver transplant recipient: A case report.

Transpl Infect Dis 2019 Mar 13:e13075. Epub 2019 Mar 13.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pleurostomophora richardsiae is a dematiaceous mold that causes subcutaneous cystic phaeohyphomycosis. Few cases of invasive P richardsiae infection have been reported. Hepatic artery thrombosis following organ transplantation caused by a fungal organism is also very rare. Read More

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http://dx.doi.org/10.1111/tid.13075DOI Listing
March 2019
1 Read

Hydatid disease of the liver with portal vein invasion mimicking portal vein thrombosis.

Arab J Gastroenterol 2019 Mar 8;20(1):50-52. Epub 2019 Mar 8.

Department of Radiology, Istanbul Medipol University School of Medicine, Istanbul, Turkey.

Hydatid cyst disease is a zoonosis caused by the parasite Echinococcus. It may infest any organ of the body, but it most frequently involves the liver, lungs, and nervous system. Portal vein involvement by hydatid cyst disease is extremely rare with only five cases published in the English literature to our knowledge. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.01.010DOI Listing

Anticoagulation in Cirrhosis and Portal Vein Thrombosis Is Safe and Improves Prognosis in Advanced Cirrhosis.

Dig Dis Sci 2019 Mar 9. Epub 2019 Mar 9.

Serviço De Gastrenterologia e Hepatologia, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Avenida Egas Moniz, 1649-035, Lisbon, Portugal.

Background: The role of portal vein thrombosis (PVT) in the natural history of cirrhosis is controversial.

Aims: We analyzed the safety and effect of anticoagulant therapy (AT) on PVT recanalization and orthotopic liver transplant (OLT)-free survival.

Methods: Eighty consecutive patients from a prospective registry of cirrhosis and non-tumoral PVT at a tertiary center were analyzed. Read More

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http://dx.doi.org/10.1007/s10620-019-05572-zDOI Listing
March 2019
2 Reads

Warfarin versus aspirin prevents portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection: A randomized clinical trial.

Int J Surg 2019 Apr 6;64:16-23. Epub 2019 Mar 6.

Departments of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, 98 West Nantong Rd, Yangzhou, Jiangsu, 225000, China. Electronic address:

Introduction: Portal vein system thrombosis (PVST) is a common, potentially life-threatening complication after splenectomy. The optimal recognized anticoagulation drugs for preventing PVST in cirrhotic patients after splenectomy remain unclear. The aim of this study is to evaluate the safety and efficacy of warfarin in preventing PVST after laparoscopic splenectomy and azygoportal disconnection (LSD). Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.02.018DOI Listing
April 2019
1 Read

Milestones in the discovery of Budd-Chiari syndrome.

Liver Int 2019 Mar 6. Epub 2019 Mar 6.

Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.

In 1845, George Budd published a brief report regarding three patients who developed an obstruction of the hepatic veins. The condition has never been reported before, and was related to sepsis and alcoholism. Fifty-three years later, Hans Chiari postulated that syphilis was causing the obstruction of the hepatic veins, and enriched the debate with clinical and pathological correlations. Read More

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http://dx.doi.org/10.1111/liv.14088DOI Listing
March 2019
6 Reads

Pediatric post-transplant hepatic kaposi sarcoma due to donor-derived human herpesvirus 8.

Pediatr Transplant 2019 Mar 6:e13384. Epub 2019 Mar 6.

Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

In areas of the world where human herpesvirus 8 (HHV-8) is endemic, Kaposi sarcoma (KS) is a common SOT-associated cancer. In the United States, where the virus is not prevalent, PTKS is rare, and there is little literature on pediatric PTKS. We present a North American female who underwent deceased donor, left lateral segment liver transplant for biliary atresia at age 11 months. Read More

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http://dx.doi.org/10.1111/petr.13384DOI Listing
March 2019
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Review of therapies for intermediate and advanced stage hepatocellular carcinoma, not suitable for curative therapies: a rapidly changing landscape.

Authors:
Brian I Carr

Hepatoma Res 2019 24;5. Epub 2019 Jan 24.

Liver Transplantation Institute, Inonu University, Malatya, Turkey and Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir 35340, Turkey.

Recent clinical trials and new agents have permitted greater clarity in the choice of effective agents for that majority of patients with hepatocellular carcinoma who have advanced disease at diagnosis and thus cannot be offered potentially curative resection, ablation or liver transplantation. The main treatment for these patients remains chemoembolization, although evidence for selective internal radiation therapy (SIRT) with SIR-Spheres or Theraphere, is beginning to suggest that the results with this may be comparable with less toxicity. Patients who have failed chemoembolization or SIRT or have metastatic disease at presentation are suitable for the multikinase inhibitor sorafenib (nexavar) or newly-approved lenvatinib (lenvima) as first line therapies. Read More

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http://dx.doi.org/10.20517/2394-5079.2018.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398440PMC
January 2019

Cytomegalovirus infection with pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance: a case and systematic review.

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

Department of Internal Medicine, Haaglanden Medical Center, Den Haag, The Netherlands.

A 62-year-old immunocompetent woman was admitted with cytomegalovirus (CMV) infection, pulmonary embolism, splenic vein thrombosis and monoclonal gammopathy of undetermined significance (MGUS). Anticoagulation therapy was started. Two months later, seroconversion of CMV IgM to IgG was observed, while the monoclonal protein was no longer detectable. Read More

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http://dx.doi.org/10.1136/bcr-2018-226448DOI Listing
March 2019
3 Reads

Treatment of aortic thrombosis with retrievable stent filter and thrombolysis: a case report.

BMC Cardiovasc Disord 2019 Mar 5;19(1):54. Epub 2019 Mar 5.

Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, No.1, East Jian She Road, Zhengzhou, 450052, China.

Background: The retrievable stent filter (RSF) has been previously used for the treatment of vena cava thrombosis. In this study, the RSF was implanted to treat aortic thrombosis and then withdrawn.

Case Presentation: A 47-years-old woman presented with severe abdominal pain and fever. Read More

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http://dx.doi.org/10.1186/s12872-019-1037-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402280PMC

Current and future pharmacological therapies for managing cirrhosis and its complications.

World J Gastroenterol 2019 Feb;25(8):888-908

Liver Unit/Division of Integrative Systems Medicine and Digestive Disease, Imperial College London, London W2 1NY, United Kingdom.

Due to the restrictions of liver transplantation, complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis. This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications, together with discussion of current controversies and potential future directions. PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety, efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis. Read More

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http://dx.doi.org/10.3748/wjg.v25.i8.888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397723PMC
February 2019
8 Reads

The management of portal vein thrombosis.

Eur J Gastroenterol Hepatol 2019 04;31(4):547

FRCPath National Mycobacterium Reference Service-South, Public Health England, London UK.

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http://dx.doi.org/10.1097/MEG.0000000000001323DOI Listing
April 2019
1 Read

Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis.

J Hepatol 2019 Feb 26. Epub 2019 Feb 26.

Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic de Barcelona, IDIBAPS, CIBERehd, European Reference Network for Rare Vascular Liver Diseases. Universitat de Barcelona, Spain. Electronic address:

Budd-Chiari Syndrome (BCS) and non-cirrhotic non-tumoral portal vein thrombosis (NCPVT) are two rare disorders, with several similarities that are categorized under the term splanchnic vein thrombosis. Both disorders are frequently associated with an underlying pro-thrombotic disorder. They can cause severe portal hypertension and usually affect oung patients, negatively influencing life expectancy when the diagnosis and treatment is not done at an early stage. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.015DOI Listing
February 2019
2 Reads

Acute portal vein thrombosis after liver transplant presenting with subtle ultrasound abnormalities: A case report and literature review.

World J Hepatol 2019 Feb;11(2):234-241

Department of Internal Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL 60637, United States.

Background: Portal vein thrombosis (PVT) after liver transplantation (LT) is an uncommon complication with potential for significant morbidity and mortality that transplant providers should be cognizant of. Recognizing subtle changes in post-operative ultrasounds that could herald but do not definitively diagnose PVT is paramount.

Case Summary: A 30-year-old female with a history of alcohol-related cirrhosis presented with painless jaundice and received a deceased donor orthotopic liver transplant. Read More

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http://dx.doi.org/10.4254/wjh.v11.i2.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393712PMC
February 2019

Balloon-Occluded Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma: A Single-Center US Preliminary Experience.

J Vasc Interv Radiol 2019 03;30(3):342-346

Division of Interventional Radiology, Icahn School of Medicine at Mount Sinai, 1184 Fifth Ave., MC Level, New York, NY 10029.

This report describes a single-center experience with balloon-occluded transarterial chemoembolization for liver-directed therapy. A total of 26 patients (11 male, 4 female; mean age, 65 y ± 7) with 28 tumors (mean diameter, 2.7 cm; range, 1. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.11.026DOI Listing

Apatinib treatment of advanced hepatocellular carcinoma with portal vein and inferior vena cava tumor thrombus: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14582

Department of Interventional Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.

Rationale: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with vascular invasion. The survival of advanced HCC is very poor. In this case study, we describe the efficacy and safety of apatinib in patient with advanced HCC as the first-line therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408098PMC
February 2019
2 Reads