8,271 results match your criteria Portal Vein Thrombosis


Hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma with portal vein thrombosis: a case-control study.

Clin Radiol 2021 Jun 8. Epub 2021 Jun 8.

Endemic Medicine and Hepatogastroenterology Department, Cairo University, Cairo, Egypt.

Aim: To study the treatment efficacy and survival of hepatic arterial infusion chemotherapy (HAIC) for patients with advanced hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT) with compensated cirrhosis in comparison with sorafenib as the standard of care therapy versus best supportive care (BSC).

Materials And Methods: This case-control study included 91 patients with advanced HCC and PVTT divided into three groups: Group 1 20 treated with HAIC, (50 mg adriamycin and 50 mg cisplatin were infused in hepatic artery); Group 2, 42 patients treated with BSC; and Group 3, 29 patients treated with sorafenib. Patients were followed up for assessment and comparison of treatment outcome by modified Response Evaluation Criteria in Solid Tumours (mRECIST) and survival. Read More

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Cancer-Associated Splanchnic Vein Thrombosis.

Semin Thromb Hemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Splanchnic vein thrombosis (SVT), which includes portal, mesenteric, and splenic vein thrombosis and the Budd-Chiari syndrome, is an infrequent manifestation of venous thromboembolism (VTE). Like typical site VTE, SVT is also frequently associated with cancer, particularly intra-abdominal solid malignancies and myeloproliferative neoplasms (MPNs). The clinical presentation of SVT is nonspecific. Read More

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Portal vein thrombosis associated with ChAdOx1 nCov-19 vaccination.

Lancet Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, University Hospital, LMU Munich, Munich, Germany.

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Portal Vein Aneurysm Treated With Trans-Jugular Intrahepatic Porto-Systemic Shunt.

Vasc Endovascular Surg 2021 Jun 11:15385744211023291. Epub 2021 Jun 11.

Division of Vascular and Interventional Radiology, Department of Radiology, The 1466Johns Hopkins Hospital, Baltimore, MD, USA.

Portal vein aneurysm (PVA) is a rare entity that can lead to hemorrhage or thrombosis. Although there is no standard treatment, most cases can be managed conservatively; intervention is reserved for symptomatic or enlarging aneurysms. For patients who are not surgical candidates due to cirrhosis and portal hypertension, endovascular creation of a trans-jugular intrahepatic porto-systemic shunt (TIPS) is an option to reduce portal venous pressure. Read More

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Transplant Direct 2021 Mar 18;7(3):e674. Epub 2021 Feb 18.

University of Maryland School of Medicine, Baltimore, MD.

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population in the perioperative period remains ill-defined.

Methods: A retrospective review of all liver transplant recipients with perioperative failure leading to transplant hepatectomy between January 1, 2014 and June 30, 2017 was performed. Read More

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Successful treatment of acute spleno-porto-mesenteric vein thrombosis after ChAdOx1 nCoV-19 vaccine. A case report.

J Crit Care 2021 Jun 4;65:72-75. Epub 2021 Jun 4.

SC Anestesia e Rianimazione II, Ospedale San Carlo Borromeo, ASST Santi Paolo e Carlo - Polo Universitario, Milano, Italy.

Several cases of deep venous thrombosis in people who had recently received Vaxzevria (previously known as COVID-19 Vaccine AstraZeneca) have recently been reported, mainly presenting as cerebral vein/cerebral venous sinus thrombosis. This syndrome has been termed "vaccine-induced immune thrombotic thrombocytopenia (VITT)". Acute spleno-porto-mesenteric vein thrombosis is an uncommon but serious condition with potential sequelae, such as small-bowel gangrene and end-stage liver failure. Read More

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[Abdominal Pain Caused by Viral Infection Is Not Always Trivial].

Praxis (Bern 1994) 2021 Jun;110(8):449-451

Zentrale Notaufnahme, Departement Interdisziplinäre Dienste, Kantonsspital St. Gallen, St. Gallen.

Abdominal Pain Caused by Viral Infection Is Not Always Trivial We report on a 28-year-old previously healthy patient with initially elevated temperature and cough and developing most severe epigastric pain and peritonism in the right upper abdomen. A "bedside" sonography revealed a portal vein thrombosis, the CT additionally partial thromboses of the vena lienalis, vena mesenterica superior. During the examination, a SARS-CoV-2 infection (IgM, IgG) was confirmed. Read More

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Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study.

PLoS One 2021 9;16(6):e0252351. Epub 2021 Jun 9.

Clinical Neurosciences Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.

Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging.

Objective: To describe the rate of TEE complications and its influence in the prognosis of hospitalized patients with COVID-19 after a cross-sectional study. Read More

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[The Treatment Options and Clinical Significance of Immune Thrombocytopenia Patients with Splanchnic Vein Thrombosis as the Initial Manifestation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):887-892

Department of Hematology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China,E-mail:

Objective: To investigate the causes, treatment options and outcomes of immune thrombocytopenia (ITP) patients with splanchnic venous thrombosis (SVT).

Methods: The clinical diagnosis, treatment and outcomes data of one 26-year-old male ITP patient with SVT as initial manifestation were collected. The possible causes and treatment options of the patients were discussed through literatures review. Read More

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Chronic Liver Disease Presenting as Immune Hemolytic Anemia: The Challenges of Diagnosis in the Critically Ill in a Resource-Limited Health Care Setting.

Cureus 2021 May 6;13(5):e14880. Epub 2021 May 6.

Department of Medicine, Lady Hardinge Medical College, Delhi, IND.

Immune hemolytic anemia is very rarely associated with chronic liver disease. Diagnosis is often complicated in critically ill patients, where an etiological diagnosis can be elusive, especially in routine health care settings. A 48-year-old man presented with jaundice for three months. Read More

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[Risk factors of blood loss during liver transplantation in children with biliary atresia and its influence on prognosis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):491-496

Department of Pediatric Organ Transplantation,Tianjin First Central Hospital,Tianjin 300192,China.

To study the risk factors for massive intraoperative blood loss in children with biliary atresia who underwent liver transplantation for the first time,and to analyze their impacts on graft survival,hospital stay and postoperative complications. The data of 613 children with biliary atresia who underwent liver transplantation at Department of Pediatric Organ Transplantation,Tianjin First Central Hospital from January 2015 to December 2018 were collected and analyzed. There were 270 males and 343 females, aged 7. Read More

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Management of a patient with a rare congenital limb malformation syndrome after SARS-CoV-2 vaccine-induced thrombosis and thrombocytopenia (VITT).

Br J Haematol 2021 Jun 7. Epub 2021 Jun 7.

Departments of Haematology.

A 54-year-old man with a rare congenital limb malformation (left image) presented to the Accident and Emergency department with a 7-day history of worsening headache, bruising and unilateral right calf swelling. There was a strong family history of a rare congenital limb deformity, his mother and his maternal grand-father having the same congenital deformity. Computed tomography (CT) showed an extensive cerebral venous sinus thrombosis and ultrasonography confirmed a concurrent venous thrombosis in the portal vein (right image, filling defect indicated by arrow). Read More

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Percutaneous transhepatic treatment of a unique portal vein malformation with portal hypertension in a pediatric patient.

CVIR Endovasc 2021 Jun 7;4(1):47. Epub 2021 Jun 7.

Department of Radiology - Papa Giovanni XXIII Hospital, University of Milano Bicocca, Piazza OMS 1, 24127, Bergamo, Italy.

Background: Anomalies of the portal venous system can be congenital or acquired, the latter being related to spontaneous thrombosis or iatrogenic alterations such as complications of perinatal catheterization of the umbilical vein. These conditions can be clinically silent for years and then manifest abruptly causing severe clinical emergencies.

Case Presentation: This case report describes the diagnosis and interventional management of a singular abnormality in the portal venous system of an 8-year-old female that led to severe portal hypertension and acute variceal bleeding. Read More

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Non-Traumatic Intramuscular Hip Hematoma in a Cirrhotic Patient With Hepatocellular Carcinoma and Portal Vein Thrombosis Treated With Sorafenib and Low Molecular Weight Heparin.

Cureus 2021 May 3;13(5):e14818. Epub 2021 May 3.

Gastroenterology, University General Hospital of Patra, Patra, GRC.

Hepatocellular carcinoma (HCC) is a common neoplasm amongst cirrhotic patients and portal vein thrombosis (PVT) is an often found complication. Sorafenib and low molecular weight heparin (LMWH) are considered part of the gold-standard treatment of such patients. Spontaneous intramuscular hematomas of the limbs induced by these agents, as an adverse event, are generally rare. Read More

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Natural language processing for the surveillance of postoperative venous thromboembolism.

Surgery 2021 Jun 2. Epub 2021 Jun 2.

Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT; Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT. Electronic address:

Background: The objective of the study was to develop a portal natural language processing approach to aid in the identification of postoperative venous thromboembolism events from free-text clinical notes.

Methods: We abstracted clinical notes from 25,494 operative events from 2 independent health care systems. A venous thromboembolism detected as part of the American College of Surgeons National Surgical Quality Improvement Program was used as the reference standard. Read More

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[Primary non function of hepatic allograft: 18 years experience of Guillermo Almenara Irigoyen National Hospital - EsSalud].

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):315-321

Departamento de Trasplantes, Hospital Nacional Guillermo Almenara, EsSalud. Lima, Perú.

Introduction: The primary nonfunction of the graft (PNF) after liver transplantation is acute graft failure, in the absence of some causal factor, such as acute thrombosis of the hepatic artery or portal vein.

Objectives: Describe the perioperative characteristics of Liver transplant patients who presented NFPI in the Transplant Department of the Guillermo Almenara Irigoyen Hospital.

Materials And Methods: Retrospective, descriptive and cross-sectional study. Read More

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Ovarian Vein to Portal Vein Reconstruction: Another Option in Liver Transplant With Portal Vein Thrombosis.

Exp Clin Transplant 2021 Jun 3. Epub 2021 Jun 3.

From the Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Portal vein thrombosis is a common complication in patients with cirrhosis and a challenge for the transplant team. Not so long ago, portal vein thrombosis was considered an absolute contraindication for liver transplant, but improvements in surgical techniques have overcome this problem in many transplant centers around the world. Here, we present the case of a 52-year-old female patient with cirrhosis from a primary biliary cholangitis and a complex portal vein thrombosis. Read More

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Acute liver failure precipitated by acute Budd-Chiari syndrome and complete portal vein thrombosis.

Clin Case Rep 2021 May 25;9(5):e04326. Epub 2021 May 25.

Division of Hepatology Department of Internal Medicine Iwate Medical University School of Medicine Yahaba-cho Japan.

Acute Budd-Chiari syndrome and complete portal vein thrombosis are important features of myeloproliferative neoplasm that may occur simultaneously, resulting in acute liver failure. Liver transplantation could be effective even in such a catastrophic condition without post-transplant complications. Read More

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Pregnancy with Paroxysmal Nocturnal Hemoglobinuria: A Case Series with Review of the Literature.

Saudi J Med Med Sci 2021 May-Aug;9(2):178-189. Epub 2021 Apr 29.

Adult Hematology/Bone Marrow Transplantation Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematopoietic stem cell disorder, and eculizumab and ravulizumab are its two approved therapies. Only few case series/reports have reported the outcomes of pregnancies in patients with PNH despite the increased risk of thrombosis. Similarly, there is limited knowledge regarding the effect of the approved treatments on conception and pregnancy outcomes. Read More

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Hepatic vein tumor thrombosis in patients with hepatocellular carcinoma: Prevalence and clinical significance.

United European Gastroenterol J 2021 Jun 2. Epub 2021 Jun 2.

Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Background: There is strong evidence that portal vein tumor thrombosis (PVTT) is associated with poor survival in patients with hepatocellular carcinoma (HCC). However, data regarding the clinical significance of hepatic vein tumor thrombosis (HVTT) is rare, particularly in Western patients.

Objective: To determine the HVTT prevalence in a Western patient population and its impact on survival. Read More

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Nomogram Model for Prediction of Portal Vein Thrombosis in Patients with Liver Cirrhosis After Splenectomy: A Retrospective Analysis of 2 Independent Cohorts.

Med Sci Monit 2021 Jun 2;27:e929844. Epub 2021 Jun 2.

Department of Gastroenterology, Zhejiang University School of Medicine, First Affiliated Hospital, Beilun Branch, Ningbo, Zhejiang, China (mainland).

BACKGROUND The aim of this study was to establish and validate an easy-to-use nomogram to predict portal vein thrombosis (PVT) in patients with cirrhosis after splenectomy and to test its predictive ability. MATERIAL AND METHODS This retrospective study included 315 patients with cirrhosis who underwent splenectomy at 2 high-volume medical centers. The least absolute shrinkage and selection operator (LASSO) regression method was used to select the predictors in the training cohort, and multivariable logistic regression analysis was performed to establish the predictive nomogram model. Read More

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Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment.

J Clin Med 2021 May 26;10(11). Epub 2021 May 26.

Division of Vascular Interventional Radiology, Department of Radiology, NYU Grossman School of Medicine, New York, NY 10016, USA.

Background: There is a lack of consensus in optimal management of portal vein thrombosis (PVT) in patients with cirrhosis. The purpose of this study is to compare the safety and thrombosis burden change for cirrhotic patients with non-tumoral PVT managed by transjugular intrahepatic portosystemic shunt (TIPS) only, anticoagulation only, or no treatment.

Methods: This single-center retrospective study evaluated 52 patients with cirrhosis and non-tumoral PVT managed by TIPS only (14), anticoagulation only (11), or no treatment (27). Read More

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The Prognostic Correlation of Heart Rate Variability at Diagnosis with Survival of Patients with Hepatocellular Carcinoma.

Diagnostics (Basel) 2021 May 17;11(5). Epub 2021 May 17.

Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Background: Heart rate variability (HRV) indices have been shown to be associated with prognosis in various types of cancer. This study aims to assess the ability of these indices to predict survival in hepatocellular carcinoma (HCC) patients after diagnosis.

Methods: We retrospectively collected data from 231 patients diagnosed with HCC between January 2014 and March 2018. Read More

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Management problems in patients with pancreatic cancer from a surgeon's perspective.

Semin Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University, Halle-Wittenberg, Halle, Germany. Electronic address:

Pancreatic cancer is one of the most lethal gastrointestinal tumor entities. Surgery is the only chance for cure; however, only a minority of patients can be offered this option. Due to the anatomic location of the gland, tumor-related problems and complications affecting the surrounding structures are common, leading to biliary and gastric outlet obstruction as well as portal vein thrombosis. Read More

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Protein C Gene Mutation in an Older Adult Patient with Septicemia-Related Visceral Vein Thrombosis.

TH Open 2021 Apr 26;5(2):e171-e173. Epub 2021 May 26.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji, Japan.

A 78-year-old Japanese male with septicemia and cholecystitis was found to have thrombosis in the left branch of intrahepatic portal vein as well as superior mesenteric vein. Visceral vein thrombosis (VVT) in this case was associated with protein C deficiency, due to a heterozygous mutation, p. Arg185Met. Read More

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Pure Laparoscopic Living Donor Left Lateral Sectionectomy Using Glissonean Approach and Original Bridging Technique.

Surg Laparosc Endosc Percutan Tech 2021 Feb 12;31(3):389-392. Epub 2021 Feb 12.

Department of Surgery, Iwate Medical University, Yahaba, Japan.

Background: Living donor liver transplantation (LDLT) is the final treatment for children with end-stage liver disease. Congenital biliary atresia (CBA) is the most common disease requiring LDLT in Japan, and a left lateral sector graft is preferably procured owing to its anatomic predictivity and identical graft volume for preschool recipients. Laparoscopic left lateral sectionectomy (L-LLS) for LDLT has been recently established; however, there is no report about the innovative technique in L-LLS. Read More

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February 2021

Prognosis of intrahepatic cholangiocarcinoma stratified by albumin-bilirubin (ALBI) grade.

Hepatol Res 2021 May 27. Epub 2021 May 27.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.

Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy. However, the characteristics and prognosis of ICC is not well-known. This study aims to reveal the relationship between liver function and prognosis of ICC. Read More

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The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.

J Hepatocell Carcinoma 2021 20;8:451-465. Epub 2021 May 20.

Department of Hepatobiliary Surgery, Zhongshan Hospital, Xiamen University, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Xiamen, Fujian, People's Republic of China.

Background: Emerging evidences have highlighted the roles of neutrophils, as the major host microenvironment component, in the development of hepatocellular carcinoma (HCC). Neutrophils extracellular traps (NETs) produced in the infection can strengthen the behavior of cancer metastasis. Here, we investigated the roles of NETs in HCC metastasis and further explore the underlying mechanism of how NETs interact with cancer. Read More

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Acute portal vein thrombosis in mild cholecystitis. A consequence of coronavirus disease 2019 infection?

Cir Cir 2021 ;89(3):399-402

Department of General Surgery and Digestive System, Hospital QuirónSalud Sur, Alcorcón. Madrid, Spain.

La infección por el virus SARS-CoV-2 provoca, además de cuadros respiratorios graves, episodios trombóticos en múltiples localizaciones debido a una mala regulación de la respuesta inmune. Presentamos el caso de un paciente con colecistitis incipiente que desarrolló trombosis portal aguda sin ningún otro antecedente salvo haber pasado de forma asintomática una infección por COVID-19. Dado que esta complicación es extremadamente infrecuente en pacientes sin factores predisponentes ni infecciones graves, consideramos que la infección por COVID-19 pudo ser un factor desencadenante de la trombosis portal y debemos de tenerlo en cuenta de cara al manejo y tratamiento de futuros casos similares. Read More

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Transhepatic Pharmacomechanical Thrombectomy of Symptomatic Acute Noncirrhotic, Nonmalignant Portomesenteric Venous Thrombosis: Midterm Results.

AJR Am J Roentgenol 2021 May 26:1-8. Epub 2021 May 26.

Department of Radiology, Okan University Hospital, Aydinli Yolu Cad No 2, Tuzla, Istanbul, Turkey, 34940.

The purpose of this study was to evaluate the safety and efficacy of transhepatic pharmacomechanical thrombectomy of symptomatic acute portomesenteric venous thrombosis. Transhepatic pharmacomechanical thrombectomy (catheter-directed thrombolysis with mechanical thrombectomy) was performed in the treatment of nine patients with symptomatic acute noncirrhotic, nonmalignant porto-mesenteric venous thrombosis. The medical records, imaging examinations, technique of transhepatic pharmacomechanical thrombectomy, and clinical outcomes were reviewed. Read More

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