7,811 results match your criteria Portal Vein Thrombosis


Anticoagulant therapy for splanchnic vein thrombosis: ISTH SSC Subcommittee Control of Anticoagulation.

J Thromb Haemost 2020 Jul;18(7):1562-1568

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

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http://dx.doi.org/10.1111/jth.14836DOI Listing

Acute Portal Vein Thrombosis in SARS-CoV-2 Infection: A Case Report.

Am J Gastroenterol 2020 Jul;115(7):1140-1142

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, U.O.C. Medicina Generale Emostasi e Trombosi, University of Milan, Milan, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000711DOI Listing

Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation.

J Thromb Haemost 2020 Jul 2. Epub 2020 Jul 2.

Department of Surgery, section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined. Read More

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http://dx.doi.org/10.1111/jth.14983DOI Listing

Capsule, a Traditional Chinese Medicinal Formulation, Enhances the Survival of Patients with Hepatocellular Carcinoma and Vp3-4 Portal Vein Tumor Thrombosis Undergoing Supportive Treatment.

J Altern Complement Med 2020 Jul 2. Epub 2020 Jul 2.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

(FFBM) capsule, a type of Chinese medicinal formulation, has decades of history in treating hepatocellular carcinoma (HCC). This retrospective study aimed to observe the effect of FFBM capsules on the 6-month survival of patients with advanced HCC and Vp3-4 portal vein tumor thrombosis (PVTT) who received supportive therapy alone. In total, 320 HCC/Vp3-4 PVTT patients underwent treatment with supportive therapy, of whom 95 took FFBM capsules and were treated with supportive therapy (FFBM group) and 225 received supportive therapy alone (control group). Read More

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http://dx.doi.org/10.1089/acm.2019.0334DOI Listing

Role of MRI in Evaluation of Spectrum of Liver Lesions in Cirrhotic Patients.

J Assoc Physicians India 2020 Apr;68(4):32-38

Speciality Medical Officer, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra.

MRI provides better intrinsic soft-tissue contrast with more enhanced depiction of even subtly different tissue properties making lesion evaluation easy. Faster sequences which capture arterial sequences better, lack of ionizing radiation and simultaneous evaluation of background liver parenchyma and the liver lesions are additional advantages of using MRI as the imaging technique of choice. Comprehensive liver imaging using MRI now includes T1, T2-weighted imaging and in- and opposed-phase, in addition to dynamic post-contrast imaging with proper breath holding techniques. Read More

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Is platelet monitoring during 7-day lusutrombopag treatment necessary in chronic liver disease patients with thrombocytopenia undergoing planned invasive procedures? A phase 3b open-label study.

Hepatol Res 2020 Jul 1. Epub 2020 Jul 1.

Institute for Gastrointestinal and Liver Diseases, Shin-yurigaoka General Hospital, Kawasaki, Japan.

Aim: Lusutrombopag is approved for thrombocytopenia in chronic liver disease patients planned to undergo invasive procedures. In previous clinical studies, lusutrombopag treatment was stopped in patients with an increase in platelet count (PC) of ≥20×10 /L from baseline and whose PC was ≥50×10 /L (discontinuation criteria). We assessed the influences of platelet monitoring during lusutrombopag administration in lusutrombopag naïve patients. Read More

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http://dx.doi.org/10.1111/hepr.13544DOI Listing

Intraoperatively self-made bovine pericardial graft for portomesenteric reconstruction in pancreatic surgery.

Langenbecks Arch Surg 2020 Jun 30. Epub 2020 Jun 30.

Department for Visceral, Thoracic and Vascular Surgery, Triemli Hospital Zurich, Zurich, Switzerland.

Purpose: Vascular encasement or infiltration of the portomesenteric veins can compromise resectability and local tumour control in pancreatic resections. So far, there is no consensus on how vascular reconstruction should be performed. Bovine pericardium has shown promising results, particularly in infected arterial vascular reconstructions. Read More

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http://dx.doi.org/10.1007/s00423-020-01920-0DOI Listing

Endothelial Damage of the Portal Vein is Associated with Heparin-Like Effect in Advanced Stages of Cirrhosis.

Thromb Haemost 2020 Jun 30. Epub 2020 Jun 30.

Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.

Background:  Portal vein thrombosis (PVT) is the most common thrombotic complication in cirrhosis; however, local risk factors involved in its pathogenesis are still not fully investigated. The aim of the study was to evaluate hemostasis and endothelial damage in the portal vein in patients with cirrhosis and portal hypertension.

Methods:  Adult cirrhotics undergoing transjugular intrahepatic portosystemic shunt were consecutively enrolled. Read More

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http://dx.doi.org/10.1055/s-0040-1713169DOI Listing

EUS guided cyanoacrylate injection to prevent rebleeding in hepatocellular carcinoma patients with variceal hemorrhage.

J Gastroenterol Hepatol 2020 Jun 30. Epub 2020 Jun 30.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.

Background And Aim: Secondary prophylaxis (SP) of variceal rebleeding was reported to improve outcomes of hepatocellular carcinoma (HCC) patients, but the optimal endoscopic approach is not well defined. We compared outcomes in HCC patients who underwent SP by EUS-guided cyanoacrylate obturation (EUS-CYA) vs no SP.

Methods: Between 2014-2018, 30 consecutive patients with inoperable HCC and recent endoscopically controlled variceal bleeding were prospectively recruited. Read More

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http://dx.doi.org/10.1111/jgh.15168DOI Listing

Acute limb ischemia in a patient with pre-fibrotic myelofibrosis complicated by heparin-induced thrombocytopenia and thrombosis - case report and systematic review of dabigatran use.

Vasa 2020 Jun 29:1-6. Epub 2020 Jun 29.

Thrombosis and Haemorrhagic Diseases Center, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milano, Italy.

A 49-year-old man was diagnosed with pre-fibrotic myelofibrosis after acute left lower-limb ischemia requiring amputation and portal vein thrombosis. After surgery he developed heparin-induced thrombocytopenia (HIT) with venous thromboembolism, successfully treated with argatroban followed by dabigatran. Our systematic review of the literature supports the use of dabigatran for suspected HIT. Read More

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http://dx.doi.org/10.1024/0301-1526/a000876DOI Listing
June 2020
1.213 Impact Factor

Diagnostic challenges in non-cirrhotic portal hypertension - porto sinusoidal vascular disease.

World J Gastroenterol 2020 Jun;26(22):3000-3011

University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca 400000, Romania.

Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension, which differ from cirrhosis through histological alterations, hemodynamic characterization and, clinical outcome. Because of the similarities in clinical presentation and imaging signs, frequently these patients, and particularly those with porto-sinusoidal vascular disease (PSVD), are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis. The most challenging differentiation to be considered is between PSVD and cirrhosis and, although not pathognomonic, liver biopsy is still the standard of diagnosis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i22.3000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304099PMC

Serum levels of inflammatory markers CRP, ESR and albumin in relation to survival for patients with hepatocellular carcinoma.

Int J Clin Pract 2020 Jun 24:e13593. Epub 2020 Jun 24.

Çukurova University, Adana, Turkey.

Introduction: Hepatocellular carcinoma is associated with several chronic inflammatory conditions. It is increasingly understood that the inflammation may be part of the carcinogenic process and prognostically important.

Objective: To evaluate the serum levels of 3 inflammation markers in relation to survival in HCC patients. Read More

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http://dx.doi.org/10.1111/ijcp.13593DOI Listing

Renoportal anastomosis in living donor liver transplantation.

Hippokratia 2019 Jul-Sep;23(3):140-142

Department of General Surgery, Medicine Faculty Hospital, University of Akdeniz, Antalya, Turkey.

Background:  In advanced cirrhotic patients, extensive mesenteric vein thrombosis extends the operative time, causes peri- and postoperative complications, and increases the mortality and morbidity in liver transplantation (LT). The anastomosis between the left renal vein and graft portal vein is one of the crucial options in such patients. However, especially in living donor liver transplantation (LDLT) practice, limited cases are published in the literature. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307504PMC

Identifying optimal candidates for liver resection or transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma.

Ann Transl Med 2020 May;8(9):586

Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Background: Recommended as the first-line treatment for advanced unresectable hepatocellular carcinoma (HCC), sorafenib has been shown to prolong median overall survival (OS) for patients. However, advanced HCC sees high heterogeneity across patient groups. Recently, a growing number of studies have indicated surgical resection and transarterial chemoembolisation (TACE) to perform well in patients with portal vein tumor thrombosis (PVTT). Read More

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http://dx.doi.org/10.21037/atm.2020.02.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290527PMC

Management of acute extensive portal vein thrombosis: the complexity and morbidity.

BMJ Case Rep 2020 Jun 21;13(6). Epub 2020 Jun 21.

Department of Surgery, Westmead Hospital, Westmead, New South Wales, Australia.

A 62-year-old patient was admitted with an acute unprovoked portal vein thrombosis with splenic and mesenteric extension. His progress was complicated by progressive small bowel ischaemia and increasing clot burden despite systemic anticoagulation. This case report describes the use of catheter-directed thrombolysis via a transjugular intrahepatic portosystemic shunt, with the disease and its treatment complicated by a ruptured iatrogenic pseudoaneurysm, abdominal compartment syndrome and small bowel infarction necessitating extensive small bowel resection. Read More

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http://dx.doi.org/10.1136/bcr-2020-234282DOI Listing

Clinical impact of pancreaticoduodenectomy for pancreatic cancer with resection of the secondary or later branches of the superior mesenteric vein.

J Hepatobiliary Pancreat Sci 2020 Jun 20. Epub 2020 Jun 20.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Purpose: To evaluate the feasibility of pancreaticoduodenectomy with resection of the second jejunal vein (J2V) for pancreatic ductal adenocarcinoma (PDAC).

Methods: Among 114 patients with PDAC undergoing pancreaticoduodenectomy with portal-superior mesenteric vein resection (PVR), surgical outcomes, and prognoses of 10 patients with resection of J2V or later branches of the superior mesenteric vein (J2VR) were compared to 104 patients with PVR above J2V (standard PVR). The reconstruction methods in the J2VR group were reviewed. Read More

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http://dx.doi.org/10.1002/jhbp.789DOI Listing

Portal vein aneurysm with acute portal vein thrombosis masquerading as a pancreatic mass.

Hematol Oncol Stem Cell Ther 2020 May 30. Epub 2020 May 30.

Department of Internal Medicine, Orlando Regional Healthcare, Orlando, FL, USA.

Portal vein aneurysm (PVA) with portal vein thrombosis (PVT) is an exceedingly rare vascular phenomenon with a limited number of reported cases in the medical literature. We describe a case of a 25-year-old man found to have a congenital PVA with PVT initially believed to be a pancreatic mass. While there remains some incongruity amongst clinicians with such a limited number of reported cases, herein, we describe the general consensus of the diagnostic approach and management of this vascular malformation. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.05.010DOI Listing

Feasibility and safety of non-operative management of portal vein aneurysms: a thirty-five year experience.

HPB (Oxford) 2020 Jun 16. Epub 2020 Jun 16.

Department of Abdominal Organ Transplantation Surgery, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

Background: Portal vein aneurysms (PVAs) are rare, though clinically challenging with post-operative mortality approaching 20% and no evidence-based treatment guidelines. We aim to describe our experience with PVAs and recommend optimum management strategies.

Methods: Demographics and clinical details of patients with PVAs admitted to our institution from 1984 to 2019 were reviewed. Read More

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http://dx.doi.org/10.1016/j.hpb.2020.05.006DOI Listing

How we should manage abnormal portal hemodynamics in living donor liver transplantation.

Liver Transpl 2020 Jun 19. Epub 2020 Jun 19.

Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, 105-8461, Japan.

We enjoyed the article by Allard et al (1), evaluating the outcomes of the patients with spontaneous portosystemic shunts (SPSS) after living donor liver transplantation (LDLT), and found that the incidence of portal complications was 8.6% in patients with a splenorenal shunt (SRS) > 8 mm and 38.5% in those with portal vein thrombosis and SRS > 15 mm, although mortality was not increased. Read More

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http://dx.doi.org/10.1002/lt.25822DOI Listing

Pathological findings suggesting vascular endothelial damage in multiple organs in chronic myelogenous leukemia patients on long-term tyrosine kinase inhibitor therapy.

Int J Hematol 2020 Jun 18. Epub 2020 Jun 18.

Department of Pathology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Japan.

A 66-year-old man with hypertension was diagnosed with chronic myelogenous leukemia in 1996. Treatment was started with hydroxycarbamide and imatinib 400 mg in 1996 + 6, which was increased to 600 mg. Although he achieved a complete cytogenic response in 1996 + 9, he could not continue imatinib because of edema; the regimen was changed to nilotinib 800 mg in 1996 + 13. Read More

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http://dx.doi.org/10.1007/s12185-020-02913-xDOI Listing

Tailored classification of portal vein thrombosis for liver transplantation: Focus on strategies for portal vein inflow reconstruction.

World J Gastroenterol 2020 Jun;26(21):2691-2701

Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Navy Medical University, Shanghai 200003, China.

Portal vein thrombosis (PVT) is currently not considered a contraindication for liver transplantation (LT), but diffuse or complicated PVT remains a major surgical challenge. Here, we review the prevalence, natural course and current grading systems of PVT and propose a tailored classification of PVT in the setting of LT. PVT in liver transplant recipients is classified into three types, corresponding to three portal reconstruction strategies: Anatomical, physiological and non-physiological. Read More

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http://dx.doi.org/10.3748/wjg.v26.i21.2691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284174PMC

Successful two-stage operation for esophageal necrosis due to proton beam therapy followed by sorafenib in a case of large hepatocellular carcinoma.

Surg Case Rep 2020 Jun 16;6(1):138. Epub 2020 Jun 16.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan.

Background: Locally advanced hepatocellular carcinoma (HCC), which is unsuitable for standard locoregional therapies, remains a challenge to manage. Among the recently developed treatments, proton beam therapy (PBT) has been reported to achieve good local control. However, in patients with large HCC adjacent to the esophagus, high-dose PBT may rarely lead to radiation-induced esophageal necrosis or perforation. Read More

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http://dx.doi.org/10.1186/s40792-020-00902-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297925PMC

Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion.

World J Hepatol 2020 May;12(5):184-206

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Zagreb 10000, Croatia.

Background: The Pringle maneuver [portal triad obstruction(PTO)] provides huge disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible solution may be stable gastric pentadecapeptide BPC 157, with already documented beneficial effects in ischemia/reperfusion conditions. Recently, BPC 157, as a cytoprotective agent, successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein; bile duct cirrhosis) through rapid collateral vessel recruitment to circumvent vessel occlusion. Read More

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http://dx.doi.org/10.4254/wjh.v12.i5.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280862PMC

A complex case of low-phospholipid-associated cholelithiasis syndrome.

Rev Esp Enferm Dig 2020 Jun 16;112. Epub 2020 Jun 16.

Gastroenterology, Hospital Professor Doutor Fernando Fonseca.

The low-phospholipid-associated cholelithiasis (LPAC) syndrome is a form of symptomatic and recurring cholelithiasis occurring in young adults, associated with mutations in the ABCB4 gene. It is a clinical syndrome characterized by at least two of the following criteria: age at onset of biliary symptoms below 40 years, intrahepatic echogenic foci or microlithiasis and recurrence of biliary symptoms after cholecystectomy. In the rare cases progressing to end-stage liver disease, a liver transplant may be indicated. Read More

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http://dx.doi.org/10.17235/reed.2020.6625/2019DOI Listing

Treatment of Noncirrhotic Portal Hypertension Secondary to Portal Vein Thrombosis With Endovascular Mesocaval Shunt Creation.

Cureus 2020 May 13;12(5):e8086. Epub 2020 May 13.

Gastroenterology and Hepatology, Indiana University, Indianapolis, USA.

Transjugular intrahepatic portosystemic shunt (TIPS) creation can be very beneficial to decrease high portal pressure and its consequent dreadful complications, such as variceal hemorrhage. However, some anatomical limitations such as portal vein thrombosis can make TIPS technically impossible to perform. Here, we describe a case of a 72-year-old female patient who previously had a Roux-En-Y choledochojejunostomy, which was complicated by portal vein thrombosis. Read More

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http://dx.doi.org/10.7759/cureus.8086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292716PMC

Microsatellite Instability-high Intrahepatic Cholangiocarcinoma with Portal Vein Tumor Thrombosis Successfully Treated with Pembrolizumab.

Intern Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Pathology, National Hospital Organization Takasaki General Medical Center, Japan.

A 60-year-old man presented with postoperative recurrence of intrahepatic cholangiocarcinoma with right portal vein tumor thrombosis (PVTT). After failure of standard chemotherapy, a liver biopsy showed that his microsatellite instability (MSI) status was high. Treatment with the immune checkpoint inhibitor (ICI) pembrolizumab was commenced, which resulted in a partial response and resolution of the PVTT. Read More

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http://dx.doi.org/10.2169/internalmedicine.4588-20DOI Listing

Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters.

Sci Rep 2020 Jun 12;10(1):9575. Epub 2020 Jun 12.

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

To evaluate the effect and mechanism of radiotherapy (RT)-sorafenib pharmacokinetics (PK) in different regimens with conventional or high dose irradiation. Between February 2012 and December 2018, 43 patients with portal vein tumor thrombosis treated with sorafenib plus conventional RT (58%) or stereotactic body radiation therapy (SBRT, 42%) were retrospectively reviewed. In vivo and in vitro studies of concurrent and sequential RT with sorafenib were designed. Read More

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http://dx.doi.org/10.1038/s41598-020-66583-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293270PMC

An Uncommon Focal Liver Lesion: Intrahepatic Splenosis.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):257-262. Epub 2020 Jun 3.

Unit of Internal Medicine, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola- Malpighi, Bologna.

Multiple focal liver lesions were incidentally detected in a patient screened by ultrasound for a recent diagnosis of lower limb deep vein thrombosis, for which anticoagulation had been initiated. Past medical history reported a post-traumatic splenectomy 15 years before. Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) showed a subcapsular lesion in liver segment 5 consistent with focal nodular hyperplasia (FNH) and multiple other nodules, with a different pattern from the former, judged as probable hepatic adenomas by MRI but probable hemangiomas by CEUS (hyperenhancement in the late phase). Read More

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http://dx.doi.org/10.15403/jgld-617DOI Listing

Serum Lipoprotein (a) on Postoperative Day 3: A Strong Predictor of Portal and/or Splenic Vein Thrombosis in Cirrhotic Patients With Splenectomy.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620912020

Shanxi Medical University, Yingze District, Taiyuan, Shanxi, People's Republic of China.

Elevated lipoprotein (a) [Lp(a)] is related to the incidence of lower limb deep vein thrombosis and pulmonary embolism. Its role in portal and/or splenic vein thrombosis (PSVT) is not established. A total of 77 consecutive patients who underwent splenectomy for cirrhotic portal hypertension were prospectively studied between 2014 and 2017. Read More

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http://dx.doi.org/10.1177/1076029620912020DOI Listing

Transjugular intrahepatic portosystemic shunt and splenectomy are more effective than endoscopic therapy for recurrent variceal bleeding in patients with idiopathic noncirrhotic portal hypertension.

World J Clin Cases 2020 May;8(10):1871-1877

Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Background: Transjugular intrahepatic portosystemic shunt (TIPS), splenectomy plus esophagogastric devascularization (SED) and endoscopic therapy + non-selective β-blockers (ET + NSBB) are widely applied in secondary prevention of recurrent gastroesophageal variceal bleeding in patients with liver cirrhosis. These different treatments, however, have not been compared in patients with idiopathic non-cirrhotic portal hypertension (INCPH).

Aim: To compare the outcomes of TIPS, SED and ET + NSBB in the control of variceal rebleeding in patients with INCPH. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i10.1871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262696PMC

Assessing Baveno VI criteria with liver stiffness measured using a new point-shear wave elastography technique (BAVElastPQ study).

Liver Int 2020 Jun 8. Epub 2020 Jun 8.

Department of Internal Medicine, Gastroenterology and Liver Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background And Aims: To date, no study has explored the potential role of ElastPQ, a novel point-SWE technique, in the assessment of clinically significant portal hypertension. The aim of our study was to determine a liver stiffness (LS) cut-off value measured by ElastPQ and laboratory parameters that could help to identify those patients who can safely avoid screening endoscopy.

Methods: Data were collected on 1422 patients who underwent ElastPQ measurement from January 2013 to January 2016 in our Department. Read More

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http://dx.doi.org/10.1111/liv.14558DOI Listing

A prospective, multicentre study in acute non-cirrhotic, non-malignant portal vein thrombosis: comparison of medical and interventional treatment.

Aliment Pharmacol Ther 2020 Jul 7;52(2):329-339. Epub 2020 Jun 7.

Freiburg, Germany.

Background: To evaluate medical versus interventional treatment (transjugular thrombus fragmentation, local thrombolysis with or without stent implantation) in patients with acute non-cirrhotic, non-malignant portal vein thrombosis (PVT).

Methods: This prospective, observational study enrolled 65 patients with acute (<28 days since begin of symptoms, no cavernoma) PVT in nine centres. Thirty patients received medical treatment and 35 patients received interventional treatment. Read More

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http://dx.doi.org/10.1111/apt.15811DOI Listing

Portal Vein Thrombosis with Splenic Infarct in β-Thalassemia Minor at High Altitude.

High Alt Med Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Hematology, Army Hospital Research and Referral, New Delhi, India.

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http://dx.doi.org/10.1089/ham.2020.0054DOI Listing
June 2020
1.818 Impact Factor

Presence of paroxysmal nocturnal hemoglobinuria in patients with idiopathic portal vein thrombosis: a single-center study.

Turk J Med Sci 2020 Jun 3. Epub 2020 Jun 3.

Background/aim: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare clonal hematopoietic stem cell disease characterized by chronic hemolytic anemia and thrombosis. We report data from a study of the occurrence of PNH among patients with idiopathic portal vein thrombosis (PVT).

Materials And Methods: Patients who were followed up with the diagnosis of idiopathic PVT were enrolled into this study. Read More

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http://dx.doi.org/10.3906/sag-1912-204DOI Listing

Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report.

Medicine (Baltimore) 2020 May;99(21):e20464

Department of Nephrology, Rheumatology, Endocrinology and Metabolism.

Introduction: Immune checkpoint inhibitors including nivolumab, an antibody against programmed death-1, have been increasingly introduced in various cancer treatment regimens, and are reported to be associated with immune-related adverse events. Nivolumab-induced renal injury is generally caused by acute interstitial nephritis and is managed by drug discontinuation and steroid therapy. Although this agent can infrequently induce glomerulonephritis, the pathogenesis and therapeutic strategy remain undetermined. Read More

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http://dx.doi.org/10.1097/MD.0000000000020464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249867PMC

[Difficulties and countermeasures for the perioperative management of megasplenectomy in patients with advanced schistosomiasis].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jan;32(3):323-325

Hunan Institute of Parasitic Diseases, WHO Collaborating Center on Schistosomiasis Control in Lake Regions, Hunan Key Laboratory of Immunology and Transmission Control of Schistosomiasis, National Key Clinical Specialty, Yueyang 414000, China.

The etiology, pathology, clinical features and prognosis of megalosplenic advanced schistosomiasis have their specific features, and therefore, the perioperative management of this disorder has special countermeasures. The review analyzes the difficult problems in the perioperative management of megalosplenic advanced schistosomiasis, including ultra - low platelet counts, extensive and severe adhesive splenomegaly, massive hemorrhage during surgery and portal vein thrombosis, and proposes countermeasures to tackle these problems, with aims to guide the clinical treatment and cure of schistosomiasis, thereby improving the prognosis, reducing complications and improving the quality of life. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019265DOI Listing
January 2020

Acute Portal Vein Thrombosis in SARS-CoV-2 Infection: A Case Report.

Am J Gastroenterol 2020 May 27. Epub 2020 May 27.

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, U.O.C. Medicina Generale Emostasi e Trombosi, University of Milan, Milan, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273956PMC

Safety and efficacy of endovascular implantation of a portal vein stent combined with iodine-125 seed-strips followed by transcatheter arterial chemoembolization with sorafenib for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis.

Br J Radiol 2020 Jun 3:20190279. Epub 2020 Jun 3.

Interventional Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

Objective: To assess the safety and efficacy of endovascular implantation of a portal vein stent combined with iodine- seed-strips followed by transcatheter arterial chemoembolization with sorafenib (PVS-I-TACE-S) for the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).

Methods: Between January 2015 and July 2017, 18 patients with PVTT caused by HCC that were treated with PVS-I-TACE-S were reviewed. The technical success, complications, changes in liver function from baseline values due to subsequent endovascular implantation of a portal vein stent combined with iodine- seed-strips (PVS-I), time-to-tumor progression (TTP) and overall survival (OS) were observed. Read More

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http://dx.doi.org/10.1259/bjr.20190279DOI Listing
June 2020
1.533 Impact Factor

Right trisectionectomy with en bloc portal vein resection for cholangiocarcinoma after preoperative stenting for main portal vein occlusion.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):174-181

Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Deprivation of portal blood flow decreases the hepatic function, thus hepatobiliary cancer patients with total occlusion of the main portal vein (PV) are usually not indicated for major hepatectomy. We herein present a 37-year-old male patient with advanced intrahepatic cholangiocarcinoma, in whom right trisectionectomy was indicated. However, the main PV was nearly completely occluded by tumor invasion, thus resolution of jaundice was markedly slow. Read More

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http://dx.doi.org/10.14701/ahbps.2020.24.2.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271116PMC

Radioembolization of hepatocarcinoma with Y glass microspheres: treatment optimization using the dose-toxicity relationship.

Eur J Nucl Med Mol Imaging 2020 May 25. Epub 2020 May 25.

HPB Surgery, Hepatology and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Aim: Transarterial radioembolization (TARE) is, by all standards, a radiation therapy. As such, according to Euratom Directive 2013/59, it should be optimized by a thorough treatment plan based on the distinct evaluation of absorbed dose to the lesions and to the non-tumoural liver (two-compartment dosimetry). Since the dosimetric prediction with Tc albumin macro-aggregates (MAA) of non-tumoural liver is much more accurate than the same prediction on lesions, treatment planning should focus on non-tumoural liver rather than on lesion dosimetry. Read More

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http://dx.doi.org/10.1007/s00259-020-04845-4DOI Listing

Portal Vein Thrombosis Associated with Trousseau Syndrome due to Urinary Bladder Squamous Cell Carcinoma in a Liver Cirrhosis Patient.

Intern Med 2020 May 23. Epub 2020 May 23.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.

A 75-year-old woman with liver cirrhosis was admitted for treatment of portal vein thrombosis (PVT). Computed tomography (CT) showed PVT, massive ascites, and multiple abdominal organ embolism. Blood tests revealed a decreased liver function (Child-Pugh grade C). Read More

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http://dx.doi.org/10.2169/internalmedicine.4112-19DOI Listing

Surgical Procedures of Portal Vein Reconstruction for Recipients With Portal Vein Thrombosis in Adult-to-Adult Living Donor Liver Transplantation.

Transplant Proc 2020 May 21. Epub 2020 May 21.

Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Mie, Japan.

Background: Portal vein (PV) reconstruction is an important surgical skill for living donor liver transplantation (LDLT), especially for patients with portal vein thrombosis (PVT). However, this technique remains a critical problem in LDLT because of technical demands and requirements for appropriate venous graft harvesting. This study aimed to evaluate the surgical procedure used for PV reconstruction and outcomes in LDLT recipients with PVT. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.155DOI Listing

Recent (non-cirrhotic) extrahepatic portal vein obstruction.

Clin Res Hepatol Gastroenterol 2020 May 21. Epub 2020 May 21.

Department of Hepatology and reference center of vascular liver diseases, Beaujon Hospital, AP-HP, 100, boulevard du Général-Leclerc, 92118 Clichy, France; French Network for Rare Liver Diseases FILFOIE, Saint-Antoine Hospital, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.

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http://dx.doi.org/10.1016/j.clinre.2020.03.003DOI Listing

Risks of Living Donor Liver Transplantation Using Small-For-Size Grafts.

Transplant Proc 2020 May 20. Epub 2020 May 20.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: In living donor liver transplantation (LDLT), a graft-to-recipient weight ratio (GRWR) of under 0.8 is recognized as the critical graft size. Our aim was to compare the survival rates of recipients with small-for-size grafts (SFSG: GRWR <0. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.136DOI Listing

"U-shaped" mesoportal jump graft to manage portal vein thrombosis during liver transplantation: A case report.

Int J Surg Case Rep 2020 15;71:73-77. Epub 2020 May 15.

General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy. Electronic address:

Introduction: Once considered a contraindication to liver transplantation, portal vein thrombosis still represents a significant challenge to the liver transplant surgeon. Yerdel grade 3 thrombosis is usually managed by interposing a donor iliac vein jump graft between graft portal vein and distal superior mesenteric vein. Venous patch is normally placed in a retrogastric position to avoid its kinking. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240169PMC

Positive consequences of splenectomy for patients with schistosomiasis-induced variceal bleeding.

Surg Endosc 2020 May 21. Epub 2020 May 21.

Department of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Background: Patients with hepatic schistosomiasis are at high risk of gastroesophageal variceal bleeding, which is highly torrential and life threatening. This study aimed to assess the effects of splenectomy on patients with schistosomiasis-induced variceal bleeding, especially those influences related to overall survival (OS) rate.

Methods: From January 2005 to December 2018, 112 patients with schistosomiasis-induced varices were enrolled. Read More

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http://dx.doi.org/10.1007/s00464-020-07648-8DOI Listing

There Is a Great Future in Plastics: Personalized Approach to the Management of Hilar Cholangiocarcinoma Using a 3-D-Printed Liver Model.

Dig Dis Sci 2020 May 21. Epub 2020 May 21.

Institute for Liver and Digestive Health, University College London, Royal Free Campus, Rowland Hill Street, London, UK.

In recent years, three-dimensional (3-D) printing technology has become a standard tool that is used in several medical applications such as education, surgical training simulation and planning, and doctor-patient communication. Although liver surgery is ideally complemented by the use of preoperative 3-D-printed models, only a few publications have addressed this topic. We report the case of a 29-year-old Caucasian woman admitted for a Klatskin tumor infiltrating the right portal vein requiring surgery that required complex vascular reconstruction. Read More

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http://dx.doi.org/10.1007/s10620-020-06326-yDOI Listing

Comment on: Thrombophilia prevalence in patients seeking laparoscopic sleeve gastrectomy: extended chemoprophylaxis may decrease portal vein thrombosis rate.

Authors:
Maria S Altieri

Surg Obes Relat Dis 2020 Apr 25. Epub 2020 Apr 25.

Division of Bariatric and Minimally Invasive Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina.

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http://dx.doi.org/10.1016/j.soard.2020.04.005DOI Listing

Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series.

Ann Intern Med 2020 May 14. Epub 2020 May 14.

Medical University of Vienna, Vienna, Austria (M.T.).

Background: Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become pandemic, with substantial mortality.

Objective: To evaluate the pathologic changes of organ systems and the clinicopathologic basis for severe and fatal outcomes.

Design: Prospective autopsy study. Read More

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http://dx.doi.org/10.7326/M20-2566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249507PMC

Vascular Resection During Hepatectomy for Liver Malignancies. Results from a Tertiary Center using Autologous Peritoneal Patch for Venous Reconstruction.

World J Surg 2020 May 16. Epub 2020 May 16.

Department of General and Oncological Surgery, Ospedale Mauriziano "Umberto I" Hospital, Largo Turati, 62, 10128, Turin, Italy.

Background: To evaluate early outcomes of venous reconstruction with peritoneal patch (PP) during resection for hepatic malignancies.

Methods: Since May 2015, PP was considered as the first option for venous reconstruction in the case of lateral resection. Between May 2015 and June 2019, 579 consecutive hepatectomies for malignancies were performed at our institution. Read More

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http://dx.doi.org/10.1007/s00268-020-05564-5DOI Listing