7,227 results match your criteria Portal Vein Thrombosis


Irreversible Electroporation as a Bridge to Liver Transplantation.

Am Surg 2019 Jan;85(1):103-110

Hepatocellular carcinoma (HCC) in proximity to major hepatic vasculature poses a risk for invasion, which would contraindicate liver transplantation, yet, is difficult to treat with thermal ablation. This study was undertaken to evaluate the feasibility of irreversible electroporation (IRE) as a bridge to transplantation for high-risk tumors. All patients with HCC in proximity to major hepatic vasculature treated with laparoscopic IRE as bridge to transplantation were studied. Read More

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January 2019

Portal Vein Thrombosis and Thrombocytopenia in Eosinophilic Granulomatosis with Polyangiitis: A Paradox?

Eur J Case Rep Intern Med 2018 28;5(11):000971. Epub 2018 Nov 28.

Division of Rheumatology, Emek Medical Center, Itzhak Rabin Blvd., Afula, Israel.

A 36-year-old woman with eosinophilic granulomatosis with polyangiitis (EGPA) presented with necrotic skin lesions and pulmonary infiltrates. There was eosinophilic vasculitis on skin biopsy, and substantial tissue eosinophilia in her bone marrow. She had unexplained worsening thrombocytopenia, which prompted a thrombophilia work-up. Read More

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http://dx.doi.org/10.12890/2018_000971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346807PMC
November 2018

Direct oral anticoagulant successfully used to treat an adult nephrotic patient complicated with portal vein thrombosis.

CEN Case Rep 2019 Feb 5. Epub 2019 Feb 5.

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Tokushima, Japan.

Thromboembolism is a major complication of nephrotic syndrome, with the renal vein being the most frequent site. However, the incidence of portal vein thrombosis (PVT) in patients with nephrotic syndrome is rare. We report a case of a relapsed steroid-dependent minimal change disease with incidental PVT. Read More

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http://dx.doi.org/10.1007/s13730-019-00381-9DOI Listing
February 2019
1 Read

The role of transjugular intrahepatic portosystemic shunt in the management of portal vein thrombosis.

Eur J Gastroenterol Hepatol 2019 03;31(3):403-404

Division of Digestive Diseases at Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel Hospital, New York City, New York, USA.

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http://dx.doi.org/10.1097/MEG.0000000000001318DOI Listing
March 2019
1 Read

Transarterial Chemoembolization related to Good Survival for Selected Patients with advanced Hepatocellular Carcinoma.

J Cancer 2019 1;10(3):665-671. Epub 2019 Jan 1.

Department of Hepatobiliary Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, China.

It remains controversial whether patients with advanced-stage hepatocellular carcinoma could be benefit from transarterial chemoembolization (TACE) treatment. The purpose of the present study is to identify predictors of survival following TACE in patients with advanced HCC. Overall, 303 patients with Barcelona Clinic Liver Cancer (BCLC) stage C HCC who were first treated with TACE from Sun Yat-sen University Cancer Centre between January 2009 and December 2013 were reviewed and enrolled in this study. Read More

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http://dx.doi.org/10.7150/jca.28528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360434PMC
January 2019

[THE STRUCTURE OF THE ILEUM AFTER THE RESECTION OF LIVER PARENCHYMA].

Georgian Med News 2018 Dec(285):100-105

State Higher Educational Institution "I. Ya. Horbachevsky Ternopil State Medical University of Ministry of Health Ukraine", Ukraine.

The ileum was morphologically examined in 45 sexually mature white male rats, which were divided into 3 groups: I group included 15 intact animals, II - 15 rats, in which 31.5% of the liver parenchyma was removed, III - 15 animals after resection 58,1% of liver parenchyma. Euthanasia of rats was performed by bloodletting under the conditions of thiopental anesthesia 1 month after the beginning of the experiment. Read More

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December 2018
1 Read

Portal Venous Flow Alterations in Hepatic Artery Thrombosis Following Liver Transplant.

Exp Clin Transplant 2019 Jan 31. Epub 2019 Jan 31.

From the Department of Radiology, Baskent University School of Medicine, Ankara, Turkey.

Objectives: The hepatic vasculature is a unique system due to a dual supply that includes the hepatic artery and portal vein, which interact when the liver vascular supply is decreased. Hepatic artery buffer response, an intrinsic regulatory mechanism that compensates for blood supply, maintains increased hepatic artery flow and caliber in response to portal vein failure. Previous studies revealed that portal vein flow showed no alterations to establish adequate blood supply in response to hepatic artery occlusion. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.2018.0128DOI Listing
January 2019
3 Reads

Case of thrombosis of the portal vein and its branches in a patient seropositive for Borrelia antigens.

Ter Arkh 2018 Nov;90(11):79-89

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.

Borreliosis after sucking ticks is an acute problem in the world. People do not go to doctors after that often, which leads to the development of various complications. Thrombosis of veins of various localization can be one of them. Read More

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http://dx.doi.org/10.26442/terarkh2018901179-89DOI Listing
November 2018
1 Read

Irreversible Electroporation for Unresectable Hepatocellular Carcinoma: Initial Experience.

Cardiovasc Intervent Radiol 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Purpose: To evaluate the efficacy and safety of irreversible electroporation (IRE) in the treatment of unresectable hepatocellular carcinoma (HCC).

Materials And Methods: A retrospective study was conducted from September 2014 to June 2017. A total of 21 HCCs in 21 patients with cirrhosis were treated with IRE. Read More

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http://dx.doi.org/10.1007/s00270-019-02164-2DOI Listing
January 2019

Prognosticators of hepatocellular carcinoma with intrahepatic vascular invasion.

Ci Ji Yi Xue Za Zhi 2019 Jan-Mar;31(1):40-46

Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Objective: The prognosis of intrahepatic vascular invasion, including unilateral or main portal vein tumor thrombosis (PVTT) and hepatic vein thrombosis, is still poor. Many patients with intrahepatic vascular invasions never receive radiotherapy (RT). In recent years, more conformal RT techniques such as intensity-modulated RT (IMRT) have been developed and applied to treat other cancers and have significantly improved treatment results and decreased side effects. Read More

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http://www.tcmjmed.com/text.asp?2019/31/1/40/230440
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http://dx.doi.org/10.4103/tcmj.tcmj_14_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334563PMC
January 2019
2 Reads

Comorbidities associated with obstructive sleep apnea: a retrospective Egyptian study on 244 patients.

Sleep Breath 2019 Jan 26. Epub 2019 Jan 26.

Department of Chest Diseases, Faculty of Medicine, University of Alexandria, 26 Mostafa kamel officer buildings, Alexandria, Egypt.

Purpose: The aim of the present study was to assess prevalence of associated comorbidities in a group of patients diagnosed with obstructive sleep apnea syndrome (OSAS).

Methods: This retrospective study enrolled 244 consecutive patients diagnosed by polysomnogram with OSAS between October 2010 and January 2015 after being referred to our Sleep-Related Breathing Disorders Unit, Chest Diseases Department, in the Alexandria Main University Hospital.

Results: Of 244 patients, 47% were men, mean age was 56. Read More

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http://dx.doi.org/10.1007/s11325-019-01783-wDOI Listing
January 2019
3 Reads

Orthotopic liver transplantation in a patient receiving apixaban for portal vein thrombosis.

J Clin Anesth 2019 Jan 23;56:41-42. Epub 2019 Jan 23.

Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2019.01.020DOI Listing
January 2019
1 Read

Anomalies of the Portal Venous System in Dogs and Cats as Seen on Multidetector-Row Computed Tomography: An Overview and Systematization Proposal.

Vet Sci 2019 Jan 22;6(1). Epub 2019 Jan 22.

San Marco Veterinary Clinic and Laboratory, via dell'Industria 3, 35030 Veggiano, Padova, Italy.

This article offers an overview of congenital and acquired vascular anomalies involving the portal venous system in dogs and cats, as determined by multidetector-row computed tomography angiography. Congenital absence of the portal vein, portal vein hypoplasia, portal vein thrombosis and portal collaterals are described. Portal collaterals are further discussed as high- and low-flow connections and categorized in hepatic arterioportal malformation, arteriovenous fistula, end-to-side and side-to-side congenital portosystemic shunts, acquired portosystemic shunts, cavoportal and porto-portal collaterals. Read More

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http://dx.doi.org/10.3390/vetsci6010010DOI Listing
January 2019
2 Reads

Nonselective beta-blockers and the risk of portal vein thrombosis in patients with cirrhosis: results of a prospective longitudinal study.

Aliment Pharmacol Ther 2019 Mar 22;49(5):582-588. Epub 2019 Jan 22.

Clichy, France.

Background: Nonmalignant portal vein thrombosis is a significant event in the course of cirrhosis that can contraindicate liver transplantation and even impact survival after the surgical procedure. Risk factors are not completely known or validated and are still debated.

Aim: To identify in patients with cirrhosis the risk factors for portal vein thrombosis that are assessable in clinical practice. Read More

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http://dx.doi.org/10.1111/apt.15137DOI Listing
March 2019
1 Read

Postoperative Portomesenteric Venous Thrombosis After Colorectal Cancer Surgery.

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Portomesenteric venous thrombosis (PMVT) can occur after colorectal surgery. Most previous studies included patients with various diseases, especially inflammatory bowel disease. The prevalence and clinical significance of PMVT developing after surgery for colorectal cancer (CRC) remain unclear. Read More

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http://link.springer.com/10.1007/s11605-018-04085-w
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http://dx.doi.org/10.1007/s11605-018-04085-wDOI Listing
January 2019
4 Reads

Nomograms in Hepatectomy Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Several conventional staging systems use tumor count as a variable for tumor classification; however, most conventional staging systems for hepatocellular carcinoma (HCC) are not specifically constructed for surgically treated patients. The aim of this study was to create a prognostic nomogram based on patient' clinical and pathological features for predicting individual patient survival after liver resection as a primary therapy for solitary hepatitis B virus (HBV)-related HCC.

Methods: This study included patients who underwent curative liver resection for preoperative treatment-naïve HBV-related HCC between April 2007 and September 2014. Read More

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http://dx.doi.org/10.1007/s11605-018-04074-zDOI Listing
January 2019
5 Reads
2.798 Impact Factor

Clinical Manifestations of Superior Mesenteric Venous Thrombosis in the Era of Computed Tomography.

Vasc Specialist Int 2018 Dec 31;34(4):83-87. Epub 2018 Dec 31.

Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Purpose: Thrombosis of the portal vein, known as pylephlebitis, is a rare and fatal complication caused by intraperitoneal infections. The disease progression of superior mesenteric venous thrombosis (SMVT) is not severe. This study aimed to determine the clinical features, etiology, and prognosis of SMVT. Read More

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http://www.vsijournal.org/journal/DOIx.php?id=10.5758/vsi.20
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http://dx.doi.org/10.5758/vsi.2018.34.4.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340699PMC
December 2018
3 Reads

Inflammatory markers C-reactive protein and PLR in relation to HCC characteristics.

J Transl Sci 2019 Jun 22;5(3). Epub 2018 Jun 22.

Mayıs University, Turkey.

Introduction: Several markers of systemic inflammation, including blood C-reactive protein, platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) have been identified as independent prognosticators for hepatocellular carcinoma (HCC).

Methods: To attempt to understand the significance of these markers, they were examined in relation to 4 tumour parameters, namely maximum tumour diameter (MTD), tumour multifocality, portal vein thrombosis (PVT) and blood alpha-fetoprotein (AFP) levels.

Results: Using linear and logistic regression models, we found that C-reactive protein and PLR on single variables, were statistically significantly related to the tumour parameters. Read More

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http://dx.doi.org/10.15761/JTS.1000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333412PMC
June 2019
1 Read

Comparison of values of CT and MRI imaging in the diagnosis of hepatocellular carcinoma and analysis of prognostic factors.

Oncol Lett 2019 Jan 12;17(1):1184-1188. Epub 2018 Nov 12.

Department of Imaging, Linyi Cancer Hospital, Linyi, Shandong 276001, P.R. China.

Value of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of small hepatocellular carcinoma (HCC), and in analysis of the prognostic factors of primary hepatocellular carcinoma (PHC) were compared. A total of 300 patients with PHC were selected from January 2013 to January 2016. Among them, 170 patients were diagnosed with small HCC. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9690
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http://dx.doi.org/10.3892/ol.2018.9690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312947PMC
January 2019
5 Reads

Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients.

Oncol Lett 2019 Jan 31;17(1):871-876. Epub 2018 Oct 31.

Department of Intervention, Qingdao Central Hospital, Qingdao Cancer Hospital, Qingdao, Shandong 266042, P.R. China.

Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. Read More

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http://dx.doi.org/10.3892/ol.2018.9648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313009PMC
January 2019
1 Read

Utility of Oral Anticoagulants as Prophylaxis of Recurrent Portal Thrombosis after Liver Transplantation.

Transplant Proc 2019 Jan - Feb;51(1):83-86. Epub 2018 Jul 10.

Liver Transplant Unit, Hepatology and Gastroenterology Department, Rio Hortega University Hospital, Valladolid, Spain.

Introduction: Portal vein thrombosis (PVT) is a relatively common finding in patients undergoing liver transplantation. Although the recommendation to prevent its recurrence is anticoagulation for a duration of 3 to 6 months, this is controversial.

Aim: The aim of our study was to determine the efficacy of oral anticoagulants (OAC) as prophylaxis for recurrent PVT after liver transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.07.014DOI Listing
July 2018
1 Read

Risk of Venous Thromboembolism for Patients with Pancreatic Ductal Adenocarcinoma Undergoing Preoperative Chemotherapy Followed by Surgical Resection.

Ann Surg Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Pancreatic ductal adenocarcinoma (PDA) is associated with a hypercoagulable state, resulting in a high risk of venous thromboembolism (VTE). Risk of VTE is well established for patients receiving chemotherapy for advanced disease and during the perioperative period for patients undergoing surgical resection. However, data are lacking for patients undergoing neoadjuvant treatment followed by resection, who may have a unique risk of VTE because of exposure to both chemotherapy and surgery. Read More

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http://dx.doi.org/10.1245/s10434-018-07148-zDOI Listing
January 2019
3 Reads
3.930 Impact Factor

A Rare Case of Triple-Negative Essential Thrombocythemia in a Young Postsplenectomy Patient: A Diagnostic Challenge.

Case Rep Hematol 2018 16;2018:9079462. Epub 2018 Dec 16.

Division of Hematology, University of Texas Health Science Center at Houston, Houston, TX, USA.

The distinction between primary and reactive thrombocytosis by bone marrow histology is very important. Reactive thrombocytosis, the most common cause of thrombocytosis, can be expected in postsplenectomy states; however, close hematological evaluation of prolonged thrombocytosis is essential to identify patients who may have an underlying myeloproliferative neoplasm. We report a 37-year-old woman who was found to have portal, mesenteric, and splenic vein thrombosis with thrombocytosis, two months after she had a splenectomy for spontaneous splenic rupture. Read More

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http://dx.doi.org/10.1155/2018/9079462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311807PMC
December 2018
2 Reads

Therapeutics for advanced hepatocellular carcinoma: Recent advances, current dilemma, and future directions.

J Cell Physiol 2019 Jan 15. Epub 2019 Jan 15.

Department of General Surgery, Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, The Sparkfire Scientific Research Group of Nanjing Medical University, Nanjing, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies and is a serious threat to people's health worldwide. The prognosis of advanced HCC is dim if left untreated. In the clinic, the treatment options for advanced HCC include surgery, radiotherapy, transcatheter arterial chemoembolization, and so forth. Read More

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http://dx.doi.org/10.1002/jcp.28048DOI Listing
January 2019
1 Read

Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis.

J Cell Mol Med 2019 Jan 11. Epub 2019 Jan 11.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, PR China.

End-stage liver fibrosis frequently progresses to portal vein thrombosis, formation of oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver failure. Mesenchymal stem cells (MSCs), when transplanted in vivo, migrate into fibrogenic livers and then differentiate into hepatocyte-like cells or fuse with hepatocytes to protect liver function. Moreover, they can produce various growth factors and cytokines with anti-inflammatory effects to reverse the fibrotic state of the liver. Read More

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http://dx.doi.org/10.1111/jcmm.14115DOI Listing
January 2019
1 Read

[Vascular causes of clinically unclear acute abdomen].

Radiologe 2019 Feb;59(2):133-138

Klinische Abteilung für Kardiovaskuläre und Interventionelle Radiologie, Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Clinical Issue: Vascular abnormalities are a rare cause of an acute abdomen. They include arterial bleeding and ischemia, the latter being either in the arterial or venous system. The most common cause of an acute ischemic abdomen is acute mesenteric ischemia caused by a thromboembolic occlusion of the superior mesenteric artery, followed by thrombotic occlusion of the portal vein, the mesenteric vein as well as the hepatic veins and the suprahepatic part of the inferior vena cava. Read More

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http://dx.doi.org/10.1007/s00117-018-0489-yDOI Listing
February 2019
3 Reads

Use of prothrombin complex concentrates in patients with decompensated liver cirrhosis is associated with thromboembolic events.

J Hepatol 2019 Jan 7. Epub 2019 Jan 7.

Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Haus 11, 60590 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.019DOI Listing
January 2019

Comparison of conservative treatment versus transcatheter arterial embolisation for the treatment of spontaneously ruptured hepatocellular carcinoma.

Pol J Radiol 2018 22;83:e311-e318. Epub 2018 Jun 22.

Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Purpose: To elucidate the prognostic factors in the spontaneous rupture of hepatocellular carcinoma (HCC) and to determine whether transcatheter arterial embolisation (TAE) is associated with better prognosis compared to conservative treatment.

Material And Methods: A retrospective multicentre study was conducted involving 71 patients with spontaneous rupture of HCC. A conservative treatment group (Cons T group) included 20 patients, while a transcatheter arterial embolisation group (TAE group) included 51 patients. Read More

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http://dx.doi.org/10.5114/pjr.2018.77024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323598PMC
June 2018
1 Read

Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients.

Thromb Haemost 2019 Jan 7. Epub 2019 Jan 7.

I Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1055/s-0038-1676981DOI Listing
January 2019
1 Read

Efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation in patients with recurrent hepatocellular carcinoma and thrombocytopenia.

Hepatol Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan.

Aims: Thrombocytopenia is often associated with chronic liver disease. Lusutrombopag is a small molecule thrombopoietin receptor agonist designed to temporarily increase the platelet count in patients with chronic liver disease for whom elective invasive procedures are planned. In the present study, the efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma were examined. Read More

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http://dx.doi.org/10.1111/hepr.13305DOI Listing
January 2019

Natural history and clinical outcomes in patients with portal vein thrombosis by etiology: A retrospective cohort study.

Thromb Res 2019 Feb 27;174:137-140. Epub 2018 Dec 27.

Division of Hematology, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Portal vein thrombosis (PVT) is an unusual-site thrombosis commonly encountered in patients with malignancies, cirrhosis, and acute abdominal inflammatory conditions (AIC). Current recommendations suggest that anticoagulation may improve recanalization rates but there is limited information on venous thromboembolism (VTE) recurrence rates and whether the etiologies of PVT respond similarly with anticoagulation.

Objective: To characterize the natural clinical course and outcomes of patients diagnosed with PVT based on etiology. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.019DOI Listing
February 2019
1 Read

Liver Transplant Survival Index for Patients with Model for End-Stage Liver Disease Score ≥ 35: Modeling Risk and Adjusting Expectations in the Share 35 Era.

J Am Coll Surg 2018 Dec 27. Epub 2018 Dec 27.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; Division of Trauma and Critical Care Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Background: The Share 35 policy for liver allocation prioritizes patients with Model for End-Stage Liver Disease (MELD) scores ≥ 35 for regional sharing of liver allografts. To better assess donor-recipient interactions and inform expectations, this study identified factors affecting graft survival independent of MELD score and derived a risk index for transplantation in the MELD ≥ 35 population.

Study Design: The United Network for Organ Sharing (UNOS) STAR database was evaluated for deceased donor liver transplants with recipients' MELD ≥ 35, between January 2006 and June 2016. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2018.12.009DOI Listing
December 2018

Portal vein thrombosis in patients with liver cirrhosis and its impact on early and long-term outcomes after liver transplantation.

Int J Clin Pract 2018 Dec 28:e13309. Epub 2018 Dec 28.

Avicenna Center for Medicine and Organ Transplant, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim: Portal vein thrombosis (PVT) is a common complication amongst patients with liver cirrhosis. The PVT risk factors and its impact on post liver transplant outcome has not been well defined, yet. This study aimed to investigate PVT prevalence, its risk factors and influence on early and long-term outcomes after liver transplantation. Read More

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http://dx.doi.org/10.1111/ijcp.13309DOI Listing
December 2018
2.566 Impact Factor

A unique case of xanthogranulomatous cholecystitis complicated by multiple liver abscesses and portal vein and hepatic artery thrombosis and occlusion.

J Surg Case Rep 2018 Dec 21;2018(12):rjy337. Epub 2018 Dec 21.

Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, 18099 Lorain Avenue Suite #108, Cleveland, OH, USA.

Xanthogranulomatous cholecystitis (XGC) is difficult to diagnose preoperatively because it often mimics gallbladder cancer. We present a case of a 64-year-old Caucasian male who presented with multiple intrahepatic abscesses, left portal vein and segmental right hepatic arterial thrombosis suspicious for extrahepatic cholangiocarcinoma who ultimately underwent an extended left hepatectomy and was noted to have XGC on final pathology. This case presents a new challenge in diagnosing XGC prior to final pathology results given the unique left portal vein, and later, right anterior portal vein thrombosis and occlusion. Read More

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http://dx.doi.org/10.1093/jscr/rjy337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302241PMC
December 2018
1 Read

Characteristics and Outcomes of Extreme Elderly Patients With Hepatocellular Carcinoma in South Korea.

In Vivo 2019 Jan-Feb;33(1):145-154

Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.

Background/aim: The number of elderly patients diagnosed with hepatocellular carcinoma (HCC) has been increasing. But there is no proper management based on age stratification in elderly patients. Therefore, we evaluated the clinical characteristics and outcomes of elderly HCC patients more than 75 years old in South Korea. Read More

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http://dx.doi.org/10.21873/invivo.11451DOI Listing
September 2018

Portal vein thrombosis and liver cirrhosis: Long-term anticoagulation is effective and safe.

Clin Res Hepatol Gastroenterol 2018 Dec 18. Epub 2018 Dec 18.

Fédération des spécialités digestives, hôpital Edouard-Herriot, hospices civils de Lyn, 69437 Lyon, France; Université Claude-Bernard Lyon 1, 69008 Lyon, France. Electronic address:

Background And Aims: Portal vein thrombosis (PVT) is a common complication of liver cirrhosis. Anticoagulation therapy is efficient, but is associated with potentially severe side-effects, especially bleeding episodes. It is therefore still unclear which patients will benefit from anticoagulation, and for what duration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22107401183026
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http://dx.doi.org/10.1016/j.clinre.2018.11.011DOI Listing
December 2018
7 Reads

Real-Time Ultrasound-Guided Thrombectomy for Extensive Portal Vein Thrombosis in Living Donor Liver Transplantation.

Transplant Proc 2018 Dec 6;50(10):3549-3551. Epub 2018 Sep 6.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Thrombectomy is a routine or common practice for treating organized portal vein thrombosis (PVT) during liver transplantation. However, this procedure is often performed in a blinded fashion and can result in insufficient thrombectomy or devastating consequences such as injury to the retropancreatic portal vein where prompt repair is very difficult. To overcome these drawbacks for blind thrombectomy, we herein describe a new technique that makes complex thrombectomy safe and easy under direct ultrasound vision. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.08.047DOI Listing
December 2018

Mild to Moderate Intrapulmonary Shunting in Pediatric Liver Transplantation: Is Screening Necessary?

Transplant Proc 2018 Dec 30;50(10):3496-3500. Epub 2018 May 30.

Organ Transplantation Centre, National Centre for Child Health and Development, Tokyo, Japan.

Background: Despite reported associations between intrapulmonary vascular shunting (IPVS) and morbidity and mortality in pediatric liver transplantation (LT), there are no guidelines for screening.

Objective: To investigate IPVS before and after pediatric LT.

Methods: Retrospective records review of all pediatric LT (n = 370) from 2005 to 2015 at a single institute in Japan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183073
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http://dx.doi.org/10.1016/j.transproceed.2018.05.025DOI Listing
December 2018
3 Reads

Predictive Factors of Tumor Recurrence and Survival in Patients with Hepatocellular Carcinoma treated with Transarterial Chemoembolization.

J Gastrointestin Liver Dis 2018 Dec;27(4):409-417

Center for Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Background And Aims: To evaluate the predictive factors for recurrence of the disease and overall survival (OS) after achieving complete response (CR) in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE).

Methods: From January 2013 to December 2017, 168 treatment-naïve patients diagnosed with HCC underwent TACE as a first-line therapy and the gathered data was retrospectively reviewed. We determined the predictive factors for complete response (CR), for recurrence after CR and for survival using the Cox proportional hazard model. Read More

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http://dx.doi.org/10.15403/jgld.2014.1121.274.fcrDOI Listing
December 2018
1 Read

Perioperative Thromboelastometry for Adult Living Donor Liver Transplant Recipients with a Tendency to Hypercoagulability: A Prospective Observational Cohort Study.

Transfus Med Hemother 2018 Nov 24;45(6):404-412. Epub 2018 Aug 24.

Anesthesia Department of Liver Institute, Menoufia University, Sheeben El Kom, Egypt.

Background: Hypercoagulability can lead to serious thromboembolic events. The aim of this study was to assess the perioperative coagulation status in liver transplant recipients with a tendency to hypercoagulability.

Methods: In a prospective observational study (South African Cochrane Registry 201405000814129), 151 potential liver transplant recipients were screened for thrombophilic factors from October 2014 to June 2017, and 57 potential recipients fulfilled the inclusion criterion of presenting two or more of the following thrombophilic factors: low protein C, low protein S, low anti-thrombin, increased homocystein, increased antiphospholipid IgG/IgM antibodies, increased lupus anticoagulant, and positive Factor V Leiden mutation. Read More

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http://dx.doi.org/10.1159/000489605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288633PMC
November 2018
1 Read
2.011 Impact Factor

Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis.

Dig Dis Sci 2018 Dec 17. Epub 2018 Dec 17.

Department of Medicine, Center for the Study of Coagulation Disorders in Liver Disease, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USA.

Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation with much surrounding controversy. Although multiple studies have shown that PVT is associated with adverse outcomes with increased morbidity and mortality rates, others have not reported the same clinical impact of PVT, arguing rather that incident PVT reflects worsening portal hypertension and the natural history of the disease. Despite this uncertainly, PVT is a dilemma facing the clinician on a daily basis often requiring a multidisciplinary team-based approach between hepatologists, transplant surgeons, interventional radiologists and hematologists. Read More

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http://dx.doi.org/10.1007/s10620-018-5427-3DOI Listing
December 2018
3 Reads

Computed tomographic angiography and ultrasonography in the diagnosis and evaluation of acute pancreatitis in dogs.

J Vet Intern Med 2019 Jan 11;33(1):79-88. Epub 2018 Dec 11.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.

Background: Acute pancreatitis in dogs is an under-diagnosed disease. Current diagnostic methods are insufficient at identifying sequelae and lack prognostic capability. Computed tomographic angiography (CTA) is accurate for diagnosis and prognostication of pancreatitis in humans. Read More

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http://dx.doi.org/10.1111/jvim.15364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335445PMC
January 2019
1 Read

Fibrinolytic Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation.

Liver Transpl 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesia, University of Miami/Jackson Memorial Hospital, Miami, FL.

Detrimental consequences of hypofibrinolysis, also known as fibrinolytic shutdown (FS), have recently arisen, and its significance in liver transplantation remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available. Based on percent (%) clot lysis 30 minutes after maximal amplitude, patients were stratified into 3 fibrinolysis phenotypes: FS, physiologic fibrinolysis, and hyperfibrinolysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lt.25394
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http://dx.doi.org/10.1002/lt.25394DOI Listing
December 2018
7 Reads

[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):280-284

Facultad de Medicina Humana, Universidad Nacional San Luis Gonzaga. Ica, Perú; Sociedad Científica de Estudiantes de Medicina de Ica (SOCEMI). Ica, Perú.

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is suffering from chronic pain in the left hypochondrium with episodes of bleeding for 3 years and sensation of thermal rise, physical examination revealed jaundice and massive splenomegaly, without neurological involvement. Severe osteoporosis, pancytopenia, and the presence of portal vein thrombosis with cavernomatous transformation complicated by portal biliopathy simulating a klatskin tumor, marrow and enzymatic studies were compatible with Gaucher disease, were shown as unexpected findings. Read More

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December 2018
6 Reads

Clinical Impact and Safety of Anticoagulants for Portal Vein Thrombosis in Cirrhosis.

Am J Gastroenterol 2019 Feb;114(2):258-266

Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy.

Objectives: Portal vein thrombosis (PVT) is a frequent complication of cirrhosis. Benefit, safety, and duration of anticoagulant treatment in this setting are controversial issues. The aim of this study was to analyze the course of PVT in a large cohort of cirrhotic patients undergoing or not anticoagulation therapy. Read More

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http://dx.doi.org/10.1038/s41395-018-0421-0DOI Listing
February 2019
2 Reads

Hypercoagulability in End-stage Liver Disease: Review of Epidemiology, Etiology, and Management.

Transplant Direct 2018 Nov 26;4(11):e403. Epub 2018 Oct 26.

Department of Anesthesiology and Perioperative Medicine, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA.

In this review, we analyze the epidemiology of thromboses related to end-stage liver disease (ESLD), discuss causes of hypercoagulability, describe susceptible populations, and critically evaluate proposed prophylaxis and treatment of thromboses. Classically, ESLD has been regarded as a model for coagulopathy, and patients were deemed to be at high risk for bleeding complications. Patients with ESLD are not auto-anticoagulated, and they do not have a lower risk of portal vein thrombosis, intracardiac thrombus formation, pulmonary embolism or hepatic artery thrombosis. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233657PMC
November 2018
2 Reads

A Rare Case of Pylephlebitis as a Complication of Cholecystocolonic Fistula.

Case Rep Surg 2018 4;2018:3931674. Epub 2018 Nov 4.

Department of Surgery, Chugoku Rosai Hospital, 1-5-1 Hirotagaya, Kure, Hiroshima 737-0193, Japan.

Pylephlebitis is defined as a septic thrombophlebitis of the portal vein and its tributaries that is associated with multiple suppurative abdominal infections. We report a case of pylephlebitis associated with a cholecystocolonic fistula (CCF). A 41-year-old man presented with upper abdominal pain and anorexia for 1 month. Read More

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https://www.hindawi.com/journals/cris/2018/3931674/
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http://dx.doi.org/10.1155/2018/3931674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247711PMC
November 2018
7 Reads

Outcomes following neonatal portal vein thrombosis: A descriptive, single-center study and review of anticoagulant therapy.

Pediatr Blood Cancer 2018 Dec 5:e27572. Epub 2018 Dec 5.

Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.

Background: Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood.

Objective: The primary aim of our study was to describe the short-term and long-term outcomes of neonatal PVT.

Methods: A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. Read More

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http://dx.doi.org/10.1002/pbc.27572DOI Listing
December 2018
4 Reads