84,261 results match your criteria Portal Vein Obstruction


Communicating with Vulnerable Patient Populations: A Randomized Intervention to Teach Inpatients to Use the Electronic Patient Portal.

Appl Clin Inform 2018 Oct 12;9(4):875-883. Epub 2018 Dec 12.

University of California, Los Angeles, California, United States.

Background:  Patient portals are expanding as a means to engage patients and have evidence for benefit in the outpatient setting. However, few studies have evaluated their use in the inpatient setting, or with vulnerable patient populations.

Objective:  This article assesses an intervention to teach hospitalized vulnerable patients to access their discharge summaries using electronic patient portals. Read More

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October 2018

Correlation and prognostic accuracy between noninvasive liver fibrosismarkers and portal pressure in cirrhosis: Role of ALBI score.

PLoS One 2018 12;13(12):e0208903. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis.

Aims: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients.

Methods: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. Read More

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December 2018

[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):280-284

Facultad de Medicina Humana, Universidad Nacional San Luis Gonzaga. Ica, Perú; Sociedad Científica de Estudiantes de Medicina de Ica (SOCEMI). Ica, Perú.

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is suffering from chronic pain in the left hypochondrium with episodes of bleeding for 3 years and sensation of thermal rise, physical examination revealed jaundice and massive splenomegaly, without neurological involvement. Severe osteoporosis, pancytopenia, and the presence of portal vein thrombosis with cavernomatous transformation complicated by portal biliopathy simulating a klatskin tumor, marrow and enzymatic studies were compatible with Gaucher disease, were shown as unexpected findings. Read More

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December 2018

The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Pediatric Gastroenterology, Hepatology and Nutrition, Atatürk University, Erzurum, Turkey.

Objectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study.

Methods: Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. Read More

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December 2018
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[Liver bud transplantation in rats].

Magy Seb 2018 Dec;71(4):163-169

Department of Organ Fabrication, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Introduction: Research has made progress in organ fabrication using an extracellular matrix, cell sheets, or organoids. Human liver tissue has been constructed using a 3-dimensional (3D) bioprinter and showed evidence that an in vitro generated liver bud was reformed in a rodent liver model. This study describes the stages of development of rat fetal organs and liver structure and reviews recent progress in liver organoid transplantation. Read More

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December 2018

The effect of leisure coping on depressive symptoms among individuals with depression: examination of potential confounding effects of physical activity and extraversion.

Psychol Health Med 2018 Dec 12:1-13. Epub 2018 Dec 12.

c School of Public Health , Indiana University , Bloomington , IN , USA.

Clinically significant depression has been consistently identified as a phenomenon directly linked to stress and stress coping. Leisure behavior as purposeful coping strategy (i.e. Read More

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December 2018

Treatment strategy for huge hepatocellular carcinoma with intrahepatic metastasis and macrovascular invasion: a case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1233-S1236

Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Macrovascular invasion, such as tumor thrombus in the major portal vein (mPVTT) or major hepatic vein (mHVTT), is regarded as indicative of an advanced stage of hepatocellular carcinoma (HCC). To date, no effective treatment has been established for this kind of HCC. We herein present a case of huge HCC with intrahepatic metastasis, mPVTT, and mHVTT. Read More

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December 2018

Actual 5-Year Survivors After Surgical Resection of Hilar Cholangiocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Stanford University, Stanford, CA, USA.

Background: The prevalence and characteristics of actual 5-year survivors after surgical treatment of hilar cholangiocarcinoma (HC) have not been described previously.

Methods: Patients who underwent resection for HC from 2000 to 2015 were analyzed through a multi-institutional registry from 10 U.S. Read More

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December 2018
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Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

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December 2018

Correction to: Effectiveness of a SCERTS Model-Based Intervention for Children with Autism Spectrum Disorder (ASD) in Hong Kong: A Pilot Study.

Authors:
Lu Yu Xiaoqin Zhu

J Autism Dev Disord 2018 Dec 11. Epub 2018 Dec 11.

Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hunghom, Hong Kong, People's Republic of China.

The article Effectiveness of a SCERTS Model-Based Intervention for Children with Autism Spectrum Disorder (ASD) in Hong Kong: A Pilot Study, written by Lu Yu and Xiaoqin Zhu was originally published electronically on the publisher's internet portal (currently SpringerLink) on June 15, 2018 without open access. Read More

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December 2018

Pancreatic neuroendocrine tumors: MR imaging features preoperatively predict lymph node metastasis.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Purposes: Predictive factors of lymph node metastasis (LNM) in pancreatic neuroendocrine tumors (pNETs) are not well established. We sought to identify the value of MR imaging features in preoperatively predicting the lymph node metastasis of pNETs.

Materials And Methods: In this study, we enrolled 108 consecutive patients with pNETs between January 2009 and June 2018. Read More

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December 2018

[Life-threatening bleeding from ileal conduit venous varices in a patient with portal hypertension].

Urologe A 2018 Dec 11. Epub 2018 Dec 11.

Radiologische Klinik, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.

Life-threatening bleeding from portosystemic varices is a feared complication of portal hypertension. Particularly, varices in atypical locations-so-called ectopic varices-pose a challenge for diagnosis and therapy. In the present article, we describe the case of a patient with liver cirrhosis and recurrent bleeding from an ileal conduit resulting from peristomal varicosis. Read More

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December 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

Clinical Impact and Safety of Anticoagulants for Portal Vein Thrombosis in Cirrhosis.

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy.

Objectives: Portal vein thrombosis (PVT) is a frequent complication of cirrhosis. Benefit, safety, and duration of anticoagulant treatment in this setting are controversial issues. The aim of this study was to analyze the course of PVT in a large cohort of cirrhotic patients undergoing or not anticoagulation therapy. Read More

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December 2018

Portal vein embolization DOES not AFFECT the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study.

Int J Surg 2018 Dec 8. Epub 2018 Dec 8.

Service de chirurgie hépatobiliaire et pancréatique et de transplantation, Département de chirurgie, Centre Hospitalier de l'Université de Montréal, Site St-Luc, Montréal, QC, Canada.

Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall survival (OS) and lower disease-free survival (DFS). The lack of adjusted models to compare these outcomes is a limitation of these studies since patients requiring PVE may differ significantly from the ones receiving upfront surgery.

Materials And Methods: Prospective cohort study of 128 patients undergoing CLM resection. Read More

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December 2018

Contrast-enhanced ultrasonography is a feasible technique for quantifying hepatic microvascular perfusion in dogs with extrahepatic congenital portosystemic shunts.

Vet Radiol Ultrasound 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Extrahepatic-congenital portosystemic shunt is a vascular anomaly that connects the portal vein to the systemic circulation and leads to a change in hepatic microvascular perfusion. However, an assessment of hepatic microvascular perfusion is limited by conventional diagnostic modalities. The aim of this prospective, exploratory study was to assess hepatic microvascular perfusion in dogs with extrahepatic-congenital portosystemic shunt using contrast-enhanced ultrasonography (CEUS) using perfluorobutane (Sonazoid ). Read More

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December 2018

Contrast-Enhanced Ultrasound for identifying circulatory complications after liver transplants in children.

Pediatr Transplant 2018 Dec 7:e13327. Epub 2018 Dec 7.

Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations performed on 34 pediatric patients who underwent a liver transplant were retrospectively included. About 53% of the examinations were performed on children 2 years old or younger. Read More

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December 2018

Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev 2018 Dec 11;12:CD011594. Epub 2018 Dec 11.

Faculty of Medicine, SEGi University, Hospital Sibu, Jalan Ulu Oya, Sibu, Sarawak, Malaysia, 96000.

Background: Several dual bronchodilator combinations of long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS). Fixed-dose combination (FDC) of aclidinium/formoterol is one of the approved LABA/LAMA therapies for people with stable COPD. Read More

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December 2018

EPID-based in vivo dosimetry using Dosimetry Check™: Overview and clinical experience in a 5-yr study including breast, lung, prostate, and head and neck cancer patients.

J Appl Clin Med Phys 2018 Dec 7. Epub 2018 Dec 7.

Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK.

Background: Independent verification of the dose delivered by complex radiotherapy can be performed by electronic portal imaging device (EPID) dosimetry. This paper presents 5-yr EPID in vivo dosimetry (IVD) data obtained using the Dosimetry Check (DC) software on a large cohort including breast, lung, prostate, and head and neck (H&N) cancer patients.

Material And Methods: The difference between in vivo dose measurements obtained by DC and point doses calculated by the Eclipse treatment planning system was obtained on 3795 radiotherapy patients treated with volumetric modulated arc therapy (VMAT) (n = 842) and three-dimensional conformal radiotherapy (3DCRT) (n = 2953) at 6, 10, and 15 MV. Read More

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December 2018
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Correction to: Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer.

Target Oncol 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.

The article Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer, written by Sarah Sammons, Noah S. Kornblum and Kimberly L. Blackwell, was originally published electronically on the publisher's internet portal (currently SpringerLink). Read More

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December 2018

Database of evidence for precision oncology portal.

Bioinformatics 2018 Dec;34(24):4315-4317

Division of Oncology, School of Medicine, St. Louis, MO, USA.

Summary: A database of curated genomic variants with clinically supported drug therapies and other oncological annotations is described. The accompanying web portal provides a search engine with two modes: one that allows users to query gene, cancer type, variant type or position for druggable mutations, and another to search for and to visualize, on three-dimensional protein structures, putative druggable sites that cluster with known druggable mutations.

Availability And Implementation: http://dinglab. Read More

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December 2018

PDX Finder: A portal for patient-derived tumor xenograft model discovery.

Nucleic Acids Res 2018 Dec 7. Epub 2018 Dec 7.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Patient-derived tumor xenograft (PDX) mouse models are a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches tailored to genomic characteristics of individual patients' tumors. PDX models are generated and distributed by a diverse group of academic labs, multi-institution consortia and contract research organizations. The distributed nature of PDX repositories and the use of different metadata standards for describing model characteristics presents a significant challenge to identifying PDX models relevant to specific cancer research questions. Read More

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December 2018
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Engaging hospitalized patients with personalized health information: a randomized trial of an inpatient portal.

J Am Med Inform Assoc 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

Objective: To determine the effects of an inpatient portal intervention on patient activation, patient satisfaction, patient engagement with health information, and 30-day hospital readmissions.

Methods And Materials: From March 2014 to May 2017, we enrolled 426 English- or Spanish-speaking patients from 2 cardiac medical-surgical units at an urban academic medical center. Patients were randomized to 1 of 3 groups: 1) usual care, 2) tablet with general Internet access (tablet-only), and 3) tablet with an inpatient portal. Read More

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December 2018

Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer.

Commun Biol 2018 7;1:218. Epub 2018 Dec 7.

4Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 Japan.

Conventional cell handling and sorting methods require manual labor, which decreases both cell quality and quantity. To purify adherent cultured cells, cell purification technologies that are high throughput without dissociation and can be utilized in an on-demand manner are expected. Here, we developed a Laser-induced, Light-responsive-polymer-Activated, Cell Killing (LiLACK) system that enables high-speed and on-demand adherent cell sectioning and purification. Read More

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December 2018

Hypercoagulability in End-stage Liver Disease: Review of Epidemiology, Etiology, and Management.

Transplant Direct 2018 Nov 26;4(11):e403. Epub 2018 Oct 26.

Department of Anesthesiology and Perioperative Medicine, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA.

In this review, we analyze the epidemiology of thromboses related to end-stage liver disease (ESLD), discuss causes of hypercoagulability, describe susceptible populations, and critically evaluate proposed prophylaxis and treatment of thromboses. Classically, ESLD has been regarded as a model for coagulopathy, and patients were deemed to be at high risk for bleeding complications. Patients with ESLD are not auto-anticoagulated, and they do not have a lower risk of portal vein thrombosis, intracardiac thrombus formation, pulmonary embolism or hepatic artery thrombosis. Read More

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November 2018

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation.

Transplant Direct 2018 Nov 23;4(11):e400. Epub 2018 Oct 23.

Division of Organ Transplantation, Department of Surgery, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA.

Background: It remains controversial if arterial perfusion in addition to portal vein perfusion during machine preservation improves liver graft quality. Comparative studies using both techniques are lacking. We studied the impact of using single or dual machine perfusion of donation after circulatory death rat livers. Read More

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November 2018

Contrast-Enhanced Ultrasound to Monitor Early Recurrence of Primary Hepatocellular Carcinoma after Curative Treatment.

Biomed Res Int 2018 7;2018:8910562. Epub 2018 Nov 7.

Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China.

Objective: To evaluate contrast-enhanced ultrasound (CEUS) for monitoring early intrahepatic recurrence of primary hepatocellular carcinoma (HCC) after curative treatment.

Methods: We prospectively analyzed 97 patients (124 nodules) with primary HCC who underwent hepatic resection or radiofrequency ablation and subsequently experienced intrahepatic recurrence. Patients were assessed with conventional ultrasound and CEUS. Read More

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November 2018

Ariadne's Thread: An Easy Way to Find Your Way Back to the Glenohumeral Joint Through the Posterior Portal Once You Have Left.

Arthrosc Tech 2018 Nov 29;7(11):e1231-e1234. Epub 2018 Oct 29.

Department of Orthopedics, University of Zurich, Balgrist University Hospital, Zurich, Switzerland.

Finding the way back into the glenohumeral space after a time-consuming rotator cuff reconstruction is not always easy because of swelling of the surrounding soft tissues. We present a safe and quick technical tip on how to reintroduce the arthroscope by means of a transarticular suture. After primary work in the glenohumeral space is performed and before the arthroscope is withdrawn from the joint, a monofilament suture is channeled from the anterior working portal through the glenohumeral joint to exit from the posterior portal. Read More

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November 2018

Endoscopic Proximal Hamstring Repair and Ischial Bursectomy Using Modified Portal Placement and Patient Positioning.

Arthrosc Tech 2018 Nov 1;7(11):e1071-e1078. Epub 2018 Oct 1.

Southern California Orthopaedic Institute, Van Nuys, California, U.S.A.

Endoscopic management has become an effective method to repair proximal hamstring injuries. However, due to the complexity of such a procedure, the dissemination of the technique of endoscopic hamstring repair has occurred slowly among orthopaedic surgeons. This Technical Note with a video modifies previously described techniques and provides safer and more simplified endoscopic management of proximal hamstring injuries. Read More

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November 2018

A Rare Case of Pylephlebitis as a Complication of Cholecystocolonic Fistula.

Case Rep Surg 2018 4;2018:3931674. Epub 2018 Nov 4.

Department of Surgery, Chugoku Rosai Hospital, 1-5-1 Hirotagaya, Kure, Hiroshima 737-0193, Japan.

Pylephlebitis is defined as a septic thrombophlebitis of the portal vein and its tributaries that is associated with multiple suppurative abdominal infections. We report a case of pylephlebitis associated with a cholecystocolonic fistula (CCF). A 41-year-old man presented with upper abdominal pain and anorexia for 1 month. Read More

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November 2018
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Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases.

World J Hepatol 2018 Nov;10(11):822-836

Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India.

End stage liver diseases (ESLD) represent a major, neglected global public health crisis which requires an urgent action towards finding a proper cure. Orthotropic liver transplantation has been the only definitive treatment modality for ESLD. However, shortage of donor organs, timely unavailability, post-surgery related complications and financial burden on the patients limits the number of patients receiving the transplants. Read More

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November 2018

Checking facts and fighting back: Why journalists should defend their profession.

PLoS One 2018 10;13(12):e0208600. Epub 2018 Dec 10.

Mass Communication, Louisiana State University, Baton Rouge, Louisiana, United States of America.

Bias accusations have eroded trust in journalism to impartially check facts. Traditionally journalists have avoided responding to such accusations, resulting in an imbalanced flow of arguments about the news media. This study tests what would happen if journalists spoke up more in defense of their profession, while simultaneously also testing effects of doing more fact checking. Read More

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December 2018

LCE: an open web portal to explore gene expression and clinical associations in lung cancer.

Oncogene 2018 Dec 7. Epub 2018 Dec 7.

Quantitative Biomedical Research Center, Department of Clinical Sciences, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, USA.

We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open access web resource-the Lung Cancer Explorer (LCE), which enables researchers and clinicians to explore these data and perform analyses. Read More

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December 2018

[Predictors of outcomes in surgery for hilar cholangiocarcinoma].

Khirurgiia (Mosk) 2018 (10):5-11

Vishnevsky National Medical Research Center of Surgery of Healthcare Ministry of Russia, Moscow, Russia.

Aim: To determine significant predictors of long-term outcomes of surgery for portal cholangiocarcinoma.

Material And Methods: Analysis included 49 out of 84 patients who were operated at the Vishnevsky Institute of Surgery in 2003-2016. Morphological examination (2011-2016) revealed great percentage of following positive variables: micro- (42. Read More

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January 2018

Five-year-term results in cirrhotics without varices, either affected or not by portal hypertensive gastropathy.

Eur J Gastroenterol Hepatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology and Pathology, University of Trieste, Trieste, Italy.

Objectives: Information is lacking on the appearance of varices in cirrhotics, either affected or not by portal hypertensive gastropathy (PHG). We assessed whether the absence or presence and the grade of PHG influenced the development of varices in cirrhotics without varices over time.

Patients And Methods: Forty cirrhotics without varices affected or not by PHG at baseline underwent follow-up endoscopy after 5 years. Read More

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December 2018

[Schistosomiasis japonica in a patient who emigrated from China: a case report].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1094-1100

Department of Gastroenterology, Iwata City Hospital.

A 37-year-old woman exhibited abnormal liver enzyme levels without any symptoms at a medical check-up. She was born and raised in Hubei, China, and had immigrated to Japan in her mid-thirties. Ultrasonography revealed an enlarged caudate lobe of the liver and a wide moniliform portal vein, whereas computed tomography revealed lined calcification on the surface of the liver and on the collateral vein of the portal vein. Read More

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January 2018
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[Unresectable combined hepatocellular-cholangiocellular carcinoma treated with transcatheter arterial chemoembolization and gemcitabine: a case study].

Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1069-1077

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital.

A 76-year-old female was referred to our hospital because of liver dysfunction. Abdominal contrasted computed tomography (CT) revealed a tumor of 7.5cm in the hepatic hilar area. Read More

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January 2018

Clinical Feasibility of a Just-in-Time Adaptive Intervention App (iREST) as a Behavioral Sleep Treatment in a Military Population: Feasibility Comparative Effectiveness Study.

J Med Internet Res 2018 Dec 7;20(12):e10124. Epub 2018 Dec 7.

Sleep and Behavioral Neuroscience Center, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.

Background: Although evidence-based cognitive behavioral sleep treatments have been shown to be safe and effective, these treatments have limited scalability. Mobile health tools can address this scalability challenge. iREST, or interactive Resilience Enhancing Sleep Tactics, is a mobile health platform designed to provide a just-in-time adaptive intervention (JITAI) in the assessment, monitoring, and delivery of evidence-based sleep recommendations in a scalable and personalized manner. Read More

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December 2018

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology.

Eur J Cancer 2018 Dec 5;106:196-211. Epub 2018 Dec 5.

Division of Hematology Oncology, Knight Cancer Institute, Oregon Health & Science University, USA; Department of Public Health and Preventive Medicine, Oregon Health & Science University, USA; Senior Scholar in the Center for Health Care Ethics, Oregon Health & Science University, USA; Division of General Medicine, Department of Medicine, Oregon Health & Science University, USA.

Background: Surrogates are frequently used in cancer medicine as the end-point of clinical trials and as the basis of United States Food and Drug Administration approvals, but they do not always represent outcomes that are important for patients. We aim to build upon previous umbrella reviews of surrogate validation studies by identifying and examining all meta-analyses of randomised controlled trials that evaluate the strength of correlation between overall survival (OS) and surrogate markers.

Methods: Google Scholar and PubMed were searched by two independent reviewers for all eligible meta-analyses of randomised controlled trials examining the correlation between a surrogate end-point and OS in medical oncology. Read More

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December 2018

Passive mesenterico-saphenous shunt: An alternative to portocaval anastomosis for tailored portal decompression during liver transplantation.

Surgery 2018 Dec 7. Epub 2018 Dec 7.

Hepatobiliopancreatic Surgery and Transplantation Department, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, France.

Background: Temporary portocaval shunt has a positive impact on short-term outcomes after liver transplantation. An alternative to temporary portocaval shunt is a distal passive decompression through mesenterico-saphenous shunt. The purpose of this study was to compare outcomes of these two types of surgical portosystemic shunt and discuss their respective place during the anhepatic phase. Read More

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December 2018

Quantification of Hemodynamic Changes in Chronic Liver Disease: Correlation of Perfusion-CT Data with Histopathologic Staging of Fibrosis.

Acad Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, 72076 Tübingen, Germany.

Rationale And Objectives: To noninvasively estimate the severity of liver fibrosis using perfusion-CT (PCT)-based quantification of dual liver blood supply prior to liver transplantation or liver resections and to correlate results with histological grading of fibrosis stages and AST-platelet ratio index.

Materials And Methods: Institutional review board approved this retrospective study. We analysed 41 consecutive patients (19 classified as Child-Pugh A, 17 as Child-Pugh B, and 5 as Child-Pugh C; MELD score ranged from 7 to 28) who underwent PCT prior to liver transplantation/liver resections between 2013 and 2016. Read More

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December 2018
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Liver histopathology in patients with hepatic masses and the Abernethy malformation.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Division of Transplant Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, IL, USA. Electronic address:

Background/purpose: The Abernethy malformation (AM) is a congenital venous malformation in which the splanchnic venous return bypasses the liver and drains directly into the systemic circulation. This deprives the liver of hepatotrophic growth factors and allows metabolic products of digestion to enter the systemic veins without the benefit of passing through the liver. The histologic features of liver biopsies in children with an AM were reviewed. Read More

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November 2018

Effect of Hyperbilirubinemia on Hepatic Hypertrophy after Portal Vein Embolization and Liver Failure after Heatectomy in Primary Biliary Malignancy.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Kyungpook National University School of Medicine, Daegu, Korea.

Purpose: To retrospectively investigate the impact of hyperbilirubinemia on future liver remnant (FLR) volume after percutaneous transhepatic portal vein embolization (PVE) and incidence of post-hepatectomy liver failure in primary biliary malignancy.

Materials And Methods: Eighty-seven patients (62 men, overall mean age 66.9 y) who underwent PVE, using Gelfoam and coils before major hepatectomy between January 2004 and June 2016, were included in this study and divided into a hyperbilirubinemia (serum total bilirubin level at PVE 5. Read More

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December 2018

Care Delivered by Pediatric Surgical Specialties Through Patient Portal Messaging.

J Surg Res 2019 Feb 11;234:231-239. Epub 2018 Oct 11.

Department of Pediatric Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Background: Patient portals are online applications that typically allow users to interact with providers using secure messaging. Portal messaging use and content have not been studied in pediatric surgical specialties.

Materials And Methods: We obtained all message threads initiated by pediatric patients/caregivers and sent to pediatric surgical providers through the Vanderbilt University Medical Center patient portal from June 1, 2014 to December 31, 2014. Read More

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February 2019

Optimal window settings in single-source dual-energy computed tomography of the abdomen.

Eur J Radiol 2018 Dec 23;109:204-209. Epub 2018 Oct 23.

Department of Radiology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Purpose: To determine the optimal window settings for monochromatic images with various energy levels in single-source dual-energy computed tomography (DECT) of the abdomen.

Materials And Methods: Two hundred consecutive patients underwent contrast-enhanced DECT to screen tumor metastases and/or recurrences after surgery for malignant tumors. Two independent radiologists reviewed eight energy levels (40, 45, 50, 55, 60, 65, 70, and 75 kilo-electron volts [keV]) of the portal venous phase monochromatic images. Read More

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December 2018
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Comparison of gadoxetic acid versus gadopentetate dimeglumine for the detection of hepatocellular carcinoma at 1.5 T using the liver imaging reporting and data system (LI-RADS v.2017).

Cancer Imaging 2018 Dec 7;18(1):48. Epub 2018 Dec 7.

Department of Radiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Medical Imaging, No138, Fenglin Road, Xuhui District, Shanghai, 200032, China.

Purpose: The goal of this study was to investigate the Liver Imaging Reporting and Data System (LI-RADS) v.2017 for the categorization of hepatocellular carcinomas (HCCs) with gadoxetic acid compared with gadopentetate dimeglumine-enhanced 1.5-T magnetic resonance imaging (MRI). Read More

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December 2018

Clinical supervision-the missing ingredient.

Authors:
Carol A Falender

Am Psychol 2018 Dec;73(9):1240-1250

Graduate School of Education and Psychology, Pepperdine University.

Clinical supervision is acknowledged as a distinct professional competence that requires specific education and training. However, it is all too often an inadequately addressed or an entirely missing ingredient in psychology curricula and clinical research, including, for example, clinical trial protocols and evidence-based treatment implementation. It is proposed that clinical supervision training follow the shift to the competence movement that has occurred in psychology education, training, and regulation generally and embrace a systematic and intentional competence model. Read More

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December 2018

Inpatients Sign On: An Opportunity to Engage Hospitalized Patients and Caregivers Using Inpatient Portals.

Med Care 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health.

Background: Inpatient portals are online patient portals linked to electronic health records that provide hospitalized patients and caregivers secure access to real-time clinical information and tools to enhance their communication with providers and hospital experience.

Objective: The main objective of this commentary was to provide a perspective that inpatient portals are innovative tools poised to engage patients and caregivers during hospitalization and, thus, enhance patient-centered care.

Results: Inpatient portals are desired by patients and caregivers and may contribute to improved recognition of their inpatient care team, knowledge of their treatment plan and overall inpatient experience. Read More

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December 2018

Feasibility of closed-MLC tracking using high sensitivity and multi-layer electronic portal imagers.

Phys Med Biol 2018 Dec 6;63(23):235030. Epub 2018 Dec 6.

Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, United States of America. Author to whom any correspondence should be addressed.

In radiation therapy, improvements in treatment conformality are often limited by movement of target tissue. To better treat the target, tumor tracking strategies involving beam's-eye-view (BEV) have been explored. However, localization surrogates like implanted fiducial markers may sometimes leave the field-of-view (FOV), as defined by the linear accelerator (LINAC) multi-leaf collimator (MLC). Read More

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December 2018
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