1,829 results match your criteria Portal Vein Obstruction


Maternal-fetal outcome in pregnancies complicated with non-cirrhotic portal hypertension: experience from a Tertiary Centre in South India.

Hepatol Int 2020 Jun 25. Epub 2020 Jun 25.

Department of Obstetrics& Gynaecology, Jawaharlal Institute of Postgraduate Medical Education & Research, Dhanvantri Nagar, Pondicherry, 605006, India.

Objective: To assess the maternal and perinatal outcomes of pregnant women with non-cirrhotic portal hypertension (NCPH).

Methods: This was an observational study done by retrieving the records of pregnant women with non-cirrhotic portal hypertension admitted to a tertiary hospital in South India, over a 9-year study period. Data regarding the clinical course, complications during pregnancy, labor, and delivery details were reviewed. Read More

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http://dx.doi.org/10.1007/s12072-020-10067-5DOI Listing

Diagnostic challenges in non-cirrhotic portal hypertension - porto sinusoidal vascular disease.

World J Gastroenterol 2020 Jun;26(22):3000-3011

University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca 400000, Romania.

Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension, which differ from cirrhosis through histological alterations, hemodynamic characterization and, clinical outcome. Because of the similarities in clinical presentation and imaging signs, frequently these patients, and particularly those with porto-sinusoidal vascular disease (PSVD), are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis. The most challenging differentiation to be considered is between PSVD and cirrhosis and, although not pathognomonic, liver biopsy is still the standard of diagnosis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i22.3000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304099PMC

Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion.

World J Hepatol 2020 May;12(5):184-206

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Zagreb 10000, Croatia.

Background: The Pringle maneuver [portal triad obstruction(PTO)] provides huge disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible solution may be stable gastric pentadecapeptide BPC 157, with already documented beneficial effects in ischemia/reperfusion conditions. Recently, BPC 157, as a cytoprotective agent, successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein; bile duct cirrhosis) through rapid collateral vessel recruitment to circumvent vessel occlusion. Read More

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http://dx.doi.org/10.4254/wjh.v12.i5.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280862PMC

Management of symptomatic portal cavernoma cholangiopathy via transplenic portal vein recanalization and TIPS.

Hepatology 2020 Jun 5. Epub 2020 Jun 5.

Northwestern Memorial Hospital, Dept. of Radiology, Chicago, United States.

Portal cavernoma cholangiopathy (PCC) is defined as an abnormality in the extrahepatic biliary system in patients with portal cavernoma . PCC is usually seen in non-cirrhotic patients secondary to extrahepatic portal vein obstruction (EHPVO), leading to cavernous formation of the portal system. Complications due to biliary compression include stricture formation, chronic cholestasis, cholelithiasis, cholangitis, and abdominal pain . Read More

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http://dx.doi.org/10.1002/hep.31411DOI Listing

Living donor liver retransplantation for primary non-function of liver graft following multivisceral transplantation in a pediatric patient.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):198-202

Division of Pediatric Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Multivisceral organ transplantation (MVOT) includes transplantation of three or more abdominal organs, generally including the small bowel, duodenum, stomach, liver, pancreas, and colon. We here presented the detailed procedures of repeat living donor liver transplantation for primary non-function of the first liver graft following MVOT in a pediatric patient. A 6-year-old girl with chronic intestinal pseudo-obstruction underwent MVOT with 5-year-old donor organs. Read More

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http://dx.doi.org/10.14701/ahbps.2020.24.2.198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271102PMC

Recent (non-cirrhotic) extrahepatic portal vein obstruction.

Clin Res Hepatol Gastroenterol 2020 May 21. Epub 2020 May 21.

Department of Hepatology and reference center of vascular liver diseases, Beaujon Hospital, AP-HP, 100, boulevard du Général-Leclerc, 92118 Clichy, France; French Network for Rare Liver Diseases FILFOIE, Saint-Antoine Hospital, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.

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http://dx.doi.org/10.1016/j.clinre.2020.03.003DOI Listing

Deep learning for identification of critical regions associated with toxicities after liver stereotactic body radiation therapy.

Med Phys 2020 May 14. Epub 2020 May 14.

Department of Oncology, Faulty of Health & Medical Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Purpose: Radiation therapy (RT) is prescribed for curative and palliative treatment for around 50% of patients with solid tumors. Radiation-induced toxicities of healthy organs accompany many RTs and represent one of the main limiting factors during dose delivery. The existing RT planning solutions generally discard spatial dose distribution information and lose the ability to recognize radiosensitive regions of healthy organs potentially linked to toxicity manifestation. Read More

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http://dx.doi.org/10.1002/mp.14235DOI Listing

Extrahepatic portal vein obstruction (EHPVO) in cirrhosis.

Clin Res Hepatol Gastroenterol 2020 Apr 17. Epub 2020 Apr 17.

Department of Hepatology, DHU Unity, Beaujon Hospital, AP-HP, 100, boulevard du Général-Leclerc, 92118 Clichy, France.

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http://dx.doi.org/10.1016/j.clinre.2020.03.014DOI Listing

Gastrointestinal Bleeding due to Pancreatic Disease-Related Portal Hypertension.

Gastroenterol Res Pract 2020 27;2020:3825186. Epub 2020 Mar 27.

Department of Gastroenterology, General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area), Shenyang 110840, China.

Background And Aims: Left-sided portal hypertension (LSPH) is a rare type of portal hypertension, which occurs due to obstruction, stenosis, or thrombosis within the splenic vein. Pancreatic diseases are the most common etiology of LSPH. This study is aimed at reporting our experiences and discussing the presentation, management, and prognosis of LSPH secondary to pancreatic diseases. Read More

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http://dx.doi.org/10.1155/2020/3825186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140141PMC

Portal Cavernoma Cholangiopathy in Children and the Management Dilemmas.

J Clin Transl Hepatol 2020 Mar 29;8(1):61-68. Epub 2020 Jan 29.

Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Portal cavernoma cholangiopathy (PCC) is one of the most harrowing complications of extrahepatic portal venous obstruction, as it determines the long-term hepatobiliary outcome. Although symptomatic PCC is rare in children, asymptomatic PCC is as common as that in adults. However, there are major gaps in the literature with regard to the best imaging strategy and management modality in children. Read More

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http://dx.doi.org/10.14218/JCTH.2019.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132017PMC

Complex Case of Aggressive Intra-abdominal Desmoid-type Fibromatosis Status Post Cholecystectomy.

Cureus 2020 Mar 6;12(3):e7193. Epub 2020 Mar 6.

Radiology, University of Mississippi Medical Center, Jackson, USA.

Desmoid-type fibromatosis (DF), also known as desmoid tumor, is an extremely rare, benign, mesenchymal fibrous tumor with no potential for metastasis. It can arise from any part of the body, most commonly extra-abdominally. Intra-abdominal DF can present sporadically, in sites of previous trauma, surgical scars and irradiation, or in association with familial adenomatous polyposis and Gardner syndrome. Read More

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http://dx.doi.org/10.7759/cureus.7193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137654PMC

Role of noninvasive tools for prediction of clinically evident portal hypertension in children.

Eur J Gastroenterol Hepatol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Noninvasive tools (NITs) for predicting varices in children with portal hypertension (PHTN) are infrequently used.

Methods: Eighty-five consecutive, treatment-naïve children with PHTN and 97 controls were enrolled study from July 2017 to November 2018. Each case was evaluated by esophagogastroduodenoscopy (EGD) and various NITs: platelet spleen size Z (PSZ), clinical prediction rule (CPR), King's variceal prediction rule (KVaPS), Splenic stiffness (SSM) and liver stiffness measurement (LSM) by point shear wave elastrography (pSWE). Read More

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http://dx.doi.org/10.1097/MEG.0000000000001716DOI Listing

Pancreatic pseudocyst-portal vein fistula: a case treated with EUS-guided cyst-drainage and a review of the literature.

Clin J Gastroenterol 2020 Mar 25. Epub 2020 Mar 25.

Department of Gastroenterology, Medicine Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa, 247-8533, Japan.

Pancreatic pseudocyst and portal vein thrombosis are common conditions resulting from acute and chronic pancreatitis. However, pancreatic pseudocyst-portal vein fistula (PPVF) is a rare and life-threatening complication. In PPVF patients, drainage or operative therapy is necessary under certain conditions, including communication between the pseudocyst and pancreatic duct, pancreatic duct stricture, pancreatic duct stone, and infection that is difficult to control with antibiotics. Read More

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http://dx.doi.org/10.1007/s12328-020-01105-8DOI Listing

Spleen stiffness measurement as a non-invasive test to evaluate and monitor portal hypertension in children with extrahepatic portal vein obstruction.

Pediatr Surg Int 2020 May 23;36(5):637-641. Epub 2020 Mar 23.

Department of Radiology, Republican Specialized Scientific Practical Medical Center of Pediatrics, Tashkent, Uzbekistan.

Purpose: The aim of the study was to test the feasibility of spleen stiffness measurement (SSM) by two-dimensional shear wave elastography (2D-SWE) and compare data on its diagnostic use with upper gastrointestinal endoscopy in children with extrahepatic portal hypertension (EHPH) before and after surgery.

Methods: A total of 44 children were included in this study [34 children with EHPH (main group)] and 10 controls (7.57 ± 1. Read More

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http://dx.doi.org/10.1007/s00383-020-04648-6DOI Listing

[A Case of Small Cell Carcinoma of the Pancreas].

Gan To Kagaku Ryoho 2019 Dec;46(13):2312-2314

Dept. of Surgery, Fukuoka Tokushukai Hospital.

A 55-year-old man was admitted to our hospital for jaundice. Magnetic resonance cholangiopancreatography showed a mass in the pancreatic head as well as biliary obstruction. We strongly suspected invasive ductal carcinoma of the pancreas. Read More

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December 2019

Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2020 03 5;3:CD011573. Epub 2020 Mar 5.

Division of Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Gastroenterology and Nutrition Department, Diagonal Paraguay 362, 8th Floor, Santiago, Region Metropolitana, Chile, 8330074.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children with chronic liver disease or portal vein obstruction. Therefore, prevention is important. Read More

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http://dx.doi.org/10.1002/14651858.CD011573.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059883PMC

Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt.

Thromb Res 2020 Apr 13;188:65-73. Epub 2020 Feb 13.

Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, the University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Introduction: Changes in the coagulation profile in children with liver disease and extrahepatic portal vein obstruction or shunt result in both bleeding and thrombosis. Routine coagulation tests do not accurately predict bleeding risk, as they are not sensitive to changes in anticoagulant factors. The thrombin generation assay could be suitable for describing the overall balance of coagulation in children with liver disease. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.02.008DOI Listing

Interventional Radiological Treatment of Paediatric Liver Transplantation Complications.

Cardiovasc Intervent Radiol 2020 May 10;43(5):765-774. Epub 2020 Feb 10.

Transplant Surgery Department, Charles University, First Faculty of Medicine, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 14021, Prague 4, Czech Republic.

Purpose: To assess the efficacy of percutaneous techniques in managing paediatric liver transplantation complications.

Material And Methods: We carried out 105 paediatric cadaveric donor liver transplantations at our centre from 2001 to 2018. Percutaneous techniques were used to treat 25 cases involving transplantation complications in 23 patients. Read More

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http://dx.doi.org/10.1007/s00270-020-02430-8DOI Listing

Endoscopic ultrasonography guided transgastric trans-portal system fine needle aspiration for diagnosing pancreatic head and uncinate process malignancy.

Ann Transl Med 2019 Dec;7(23):719

Department of Endoscopy, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Background: Endoscopic ultrasonography guided fine needle aspiration (EUS-FNA) is a well-established technique for diagnosing pancreatic malignancy. In general, tissue of pancreatic head and uncinate process lesions is obtained via a transduodenal approach. However, this tissue-acquisition modality is not applicable in cases of pyloric obstruction and duodenal bulb ulceration. Read More

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http://dx.doi.org/10.21037/atm.2019.11.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989987PMC
December 2019

Gastroduodenal Emphysema with Portal Venous Air due to Congenital Duodenal Web in a Child: A Case Report and Review of Literature.

Case Rep Pediatr 2020 17;2020:9897208. Epub 2020 Jan 17.

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura 50008, Sri Lanka.

Congenital duodenal web causing proximal duodenal obstruction leading to gastroduodenal emphysema is a very rare presentation in infancy. Due to persistent 
peristalsis against the duodenal membrane, there is progressive stretching of the duodenal web leading to windsock deformity. We describe a rare case of a child with gastroduodenal emphysema and portal venous air due to duodenal obstruction secondary to a duodenal web. Read More

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http://dx.doi.org/10.1155/2020/9897208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988673PMC
January 2020

Portal venous systems shown by extrahepatic portal angiography in children with extrahepatic portal venous obstruction: Imaging features and clinical relevance.

J Vasc Surg Venous Lymphat Disord 2020 Feb 1. Epub 2020 Feb 1.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China; Graduate School of Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Objective: This study investigated the morphologic changes of portal cavernoma in children with extrahepatic portal venous obstruction and explored the relationship with prognosis.

Methods: From February 2008 to October 2017, there were 107 patients with cavernous transformation of the portal vein admitted to our hospital. Rex shunts were performed in 99 cases, Warren shunts in 7 cases, and laparoscopic splenic vessel ligation in 1 case. Read More

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http://dx.doi.org/10.1016/j.jvsv.2019.11.016DOI Listing
February 2020

Long-term Outcomes and Health Perceptions in Pediatric-onset Portal Hypertension Complicated by Varices.

J Pediatr Gastroenterol Nutr 2020 May;70(5):628-634

Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objectives: Outcomes of pediatric-onset portal hypertension are poorly defined. We aimed to assess population-based long-term outcomes of pediatric-onset portal hypertension complicated by varices.

Methods: All children with esophageal varices (n = 126) were identified from 14,144 single nationwide referral center endoscopy reports during 1987 to 2013, and followed up through national health care and death registers. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002643DOI Listing

Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension: Its relevance in the management of portal hypertension.

World J Gastrointest Surg 2020 Jan;12(1):1-8

Department of Cardiology, JIPMER, Pondicherry 605006, India.

Background: Portal hypertension (PH) is associated with changes in vascular structure and function of the portosplenomesenteric system (PSMS). This is referred to as portal hypertensive vasculopathy. Pathological abnormalities of PSMS has been described in the literature for cirrhotic patients. Read More

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http://dx.doi.org/10.4240/wjgs.v12.i1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943091PMC
January 2020

Sclerotherapy versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children and adolescents with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2020 01 10;1:CD011659. Epub 2020 Jan 10.

Division of Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Gastroenterology and Nutrition Department, Diagonal Paraguay 362, 8th Floor, Santiago, Region Metropolitana, Chile, 8330074.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children with chronic liver disease or portal vein obstruction. Prevention is therefore important. Read More

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http://dx.doi.org/10.1002/14651858.CD011659.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956467PMC
January 2020

Correlation of Hepatic Artery Resistive Index with Portal Pressure and Serum Nitric Oxide Levels in Patients with Extrahepatic Portal Vein Obstruction.

J Indian Assoc Pediatr Surg 2020 Jan-Feb;25(1):38-42. Epub 2019 Nov 27.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Aim: The aim was to study the correlation of hepatic artery resistive index (HARI) with the portal pressure (PP) and its surrogate marker serum nitric oxide (NO) levels and to determine the validity of HARI as noninvasive indirect marker of PP in extrahepatic portal venous obstruction (EHPVO) pre- and postoperatively.

Methods: A prospective study was conducted on 19 patients with EHPVO undergoing proximal lienorenal (LR) shunt or devascularization from February 2016 to January 2018. HARI, calculated from Doppler sonography, and NO were measured preoperatively and 14, 30 and 90 days postoperatively. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_244_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910058PMC
November 2019

Trans-Right-Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension.

Pediatr Crit Care Med 2020 04;21(4):340-349

All authors: Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.

Objectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension controls.

Design: Prospective blood collection during cardiac catheterization from the superior vena cava, pulmonary artery, and ascending aorta in 12 children with pulmonary arterial hypertension and nine matched nonpulmonary arterial hypertension controls, followed by an unbiased quantitative polymerase chain reaction array screen for 754 microRNAs in plasma.

Setting: Children's hospital at a medical school. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002207DOI Listing

Portal vein thrombosis secondary to postoperative gastric cancer: Report of two cases.

J Int Med Res 2019 Dec 16:300060519892417. Epub 2019 Dec 16.

Department of Gastrointestinal Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Few cases of portal vein thrombosis secondary to gastric cancer surgery have been reported. Here we report the diagnosis and management of two such cases. Case 1: Gastric carcinoma with acute hematemesis was detected by endoscopy in the gastric body of a 48-year-old woman. Read More

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http://dx.doi.org/10.1177/0300060519892417DOI Listing
December 2019

CT findings in five dogs with surgically confirmed colonic torsion.

Vet Radiol Ultrasound 2020 Mar 14;61(2):190-196. Epub 2019 Dec 14.

Diagnostic Imaging Department, Pride Veterinary Centre, Derby, UK.

Colonic torsion is a life-threatening condition that results in colonic ischemia, necrosis, perforation, sepsis, and eventual death. The aim of this multicenter, retrospective case series study was to describe the CT findings in dogs with surgically confirmed colonic torsion. Medical records were searched for dogs with surgically confirmed colonic torsion following abdominal CT. Read More

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http://dx.doi.org/10.1111/vru.12830DOI Listing
March 2020
5 Reads

Prevalence, nature, and predictors of colonic changes in children with extrahepatic portal vein obstruction.

Gastrointest Endosc 2020 Apr 7;91(4):849-858. Epub 2019 Dec 7.

Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, India.

Background And Aims: The medical literature on colonic changes in children with extrahepatic portal venous obstruction (EHPVO) is limited. We evaluated EHPVO children for prevalence, nature, and relation of colonic changes with disease duration, extent of splenoportal axis (SPA) thrombosis, portal hypertensive gastropathy (PHG), and esophageal varices (EVs). The correlation between histologic and endoscopic changes was studied. Read More

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http://dx.doi.org/10.1016/j.gie.2019.11.042DOI Listing

Complications of liver transplant.

Abdom Radiol (NY) 2019 Dec 3. Epub 2019 Dec 3.

Department of Radiology, Mayo Clinic, Phoenix, AZ, USA.

Liver transplantation has become a definitive treatment for patients with end-stage liver disease and those meeting Milan criteria for hepatocellular carcinoma. The morbidity and mortality associated with liver transplantation continues to decrease thanks to refinements in surgical technique, immunosuppression, and imaging. In particular, imaging plays a vital role by facilitating early detection of post-operative complications and enabling prompt treatment. Read More

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http://dx.doi.org/10.1007/s00261-019-02340-5DOI Listing
December 2019

Embolization for delayed arterial bleeding after percutaneous self-expandable metallic stent placement in patients with malignant biliary obstruction.

Br J Radiol 2020 Apr 11;93(1108):20190637. Epub 2019 Dec 11.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Objectives: To retrospectively evaluate the safety and efficacy of transcatheter arterial embolization (TAE) for delayed arterial bleeding secondary to percutaneous self-expandable metallic stent (SEMS) placement in patients with malignant biliary obstruction (MBO).

Methods: From January 1997 to September 2017, 1858 patients underwent percutaneous SEMS placement for MBO at a single tertiary referral center. Among them, 19 patients (mean age, 70. Read More

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http://dx.doi.org/10.1259/bjr.20190637DOI Listing

Clinico-epidemiological Profile of Extra Hepatic Portal Vein Obstruction: A Tertiary Care Hospital Based Retrospective Study.

Kathmandu Univ Med J (KUMJ) 2019 Jan.-Mar;17(65):30-34

Department of Internal Medicine, BP Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal.

Background Extra hepatic portal vein obstruction (EHPVO) is a common cause of portal hypertension in the developing countries (up to 30% of all variceal bleeders) and is second to cirrhosis in the West (up to 5-10%). Our understanding of the disease is poor compared with other illnesses. Objective To undertake a retrospective study of the clinicoepidemiological profile of Extra hepatic portal vein obstruction in a tertiary care hospital in eastern Nepal. Read More

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February 2020
4 Reads

Long-term results of variceal bleeding management in 302 patients with chronic extrahepatic portal vein obstruction.

J Gastroenterol Hepatol 2020 Jun 6;35(6):1049-1056. Epub 2019 Dec 6.

Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Background And Aim: Treatment modalities of variceal bleeding or rebleeding for extrahepatic portal vein obstruction (EHPVO) are limited, and their long-term results and prognostic factors are unclear. This study aimed at assessing the long-term results of EHPVO treated with current recommendations and investigating the influencing factors.

Methods: Between 2009 and 2016, 302 consecutive patients with EHPVO were included. Read More

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http://dx.doi.org/10.1111/jgh.14902DOI Listing

Endoscopic prophylaxis and factors associated with bleeding in children with extrahepatic portal vein obstruction.

J Pediatr (Rio J) 2019 Oct 27. Epub 2019 Oct 27.

Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Departamento de Pediatria, Grupo de Gastroenterologia Pediátrica, Belo Horizonte, MG, Brazil.

Objectives: This study aimed to evaluate factors associated with upper digestive hemorrhage and primary and secondary endoscopic prophylaxis outcomes in children with extrahepatic portal vein obstruction.

Methods: This observational and prospective study included 72 children with extrahepatic portal vein obstruction who were followed from 2005 to 2017. Risk factors associated with upper digestive hemorrhage and the results of primary and secondary prophylaxis of these patients were evaluated. Read More

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http://dx.doi.org/10.1016/j.jped.2019.08.010DOI Listing
October 2019
1 Read

Left-sided portal hypertension due to retroperitoneal fibrosis treated with an oesophagus preserving, modified Sugiura procedure.

Ann R Coll Surg Engl 2020 Feb 29;102(2):e48-e50. Epub 2019 Oct 29.

La Princesa University Hospital, Madrid, Spain.

Left-sided portal hypertension is a very uncommon condition and retroperitoneal fibrosis has rarely been reported as a cause. We present the case of a 77-year-old man with retroperitoneal fibrosis obstructing the splenic vein and causing recurrent episodes of upper gastrointestinal bleeding. Computed tomography showed a retroperitoneal mass as being responsible for the obstruction of the splenic vein, splenomegaly, and diffuse varices around the gastrosplenic and gastrohepatic ligaments. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996417PMC
February 2020
1 Read

Outcome of portosystemic shunt surgery on pre-existing cholangiopathy in children with extrahepatic portal vein obstruction.

J Hepatobiliary Pancreat Sci 2020 Mar 26;27(3):141-148. Epub 2019 Nov 26.

Department of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: This study was performed to assess the effect of portosystemic shunt surgery (PSS) on portal cavernoma cholangiopathy (PCC) in children with extrahepatic portal vein obstruction (EHPVO).

Methods: Children with EHPVO and PCC (unfit for Meso-Rex shunt) underwent magnetic resonance cholangiogram (MRC) and magnetic resonance portovenogram (MRPV) before non-selective PSS. PCC was graded by modified Llop classification. Read More

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http://dx.doi.org/10.1002/jhbp.692DOI Listing
March 2020
5 Reads

Small Intrahepatic Vein Budd-Chiari Syndrome Complicated by Peritonitis.

ACG Case Rep J 2019 Jul 2;6(7):e00121. Epub 2019 Jul 2.

Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Budd-Chiari syndrome is a rare disorder with significant liver-related complications. We present a 28-year-old woman with a 1-month history of weight loss and ascites. Hepatic venogram showed patent hepatic veins and inferior vena cava; however, there was an increased hepatic venous pressure gradient, which is clinically significant for portal hypertension. Read More

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http://dx.doi.org/10.14309/crj.0000000000000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722369PMC
July 2019
2 Reads

Sinusoidal obstruction syndrome: A systematic review of etiologies, clinical symptoms, and magnetic resonance imaging features.

World J Clin Cases 2019 Sep;7(18):2746-2759

Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, Sichuan Province, China.

Background: Sinusoidal obstruction syndrome (SOS) is a kind of rare liver disease which is characterized by damage to small hepatic vessels, affecting particularly the sinusoidal endothelium. Due to the special etiology and high mortality, early diagnosis of SOS is significant for clinical survival and prognosis.

Aim: To generalize the common etiologies and clinical symptoms of SOS and summarize the characteristic magnetic resonance imaging (MRI) features so as to provide more valuable information for early diagnosis of SOS. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i18.2746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789402PMC
September 2019
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Gynura Segetum Related Hepatic Sinusoidal Obstruction Syndrome: A Liver Disease with High Mortality and Misdiagnosis Rate.

Curr Pharm Des 2019 ;25(35):3762-3768

Department of Liver Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518100, China.

Background And Aim: Gynura segetum (Tusanqi or Jusanqi) is widely used in China as a herbal remedy, however, it has often been associated with hepatic sinusoidal obstruction syndrome (HSOS). Its extent in inducing hepatotoxicity is not sufficiently understood. Hence, we aimed to identify the characteristic features of Gynura segetum associated HSOS. Read More

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http://dx.doi.org/10.2174/1381612825666191007162024DOI Listing
June 2020
2 Reads
3.452 Impact Factor

Noncirrhotic Portal Hypertension: Current and Emerging Perspectives.

Clin Liver Dis 2019 11;23(4):781-807

Department of Hepatology, Institute of Liver & Biliary Sciences (ILBS), D-1, Vasant Kunj, New Delhi 110 070, India. Electronic address:

Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are prototype noncirrhotic causes of portal hypertension (PHT), characterized by normal hepatic venous pressure gradient, variceal bleeds, and moderate to massive splenomegaly with preserved liver synthetic functions. Infections, toxins, and immunologic, prothrombotic and genetic disorders are possible causes in IPH, whereas prothrombotic and local factors around the portal vein lead to EHPVO. Growth failure, portal biliopathy, and minimal hepatic encephalopathy are long-term concerns in EHPVO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10893261193004
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http://dx.doi.org/10.1016/j.cld.2019.07.006DOI Listing
November 2019
10 Reads

Band ligation versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

Cochrane Database Syst Rev 2019 09 24;9:CD010546. Epub 2019 Sep 24.

Gastroenterology and Nutrition Department, Division of Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, 85 Lira, Santiago, Region Metropolitana, Chile, 8330074.

Background: Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including haemorrhage from oesophageal and gastrointestinal varices. Variceal haemorrhage commonly occurs in children with chronic liver disease or portal vein obstruction. Prevention is therefore important. Read More

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http://dx.doi.org/10.1002/14651858.CD010546.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758973PMC
September 2019
3 Reads

Endovascular stent placement for venous complications following pediatric liver transplantation: outcomes and indications.

Pediatr Surg Int 2019 Nov 18;35(11):1185-1195. Epub 2019 Sep 18.

Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Purpose: Advances in interventional radiology (IVR) treatment have notably improved the prognosis of hepatic vein (HV) and portal vein (PV) complications following pediatric living donor liver transplantation (LDLT); however, graft failure may develop in refractory cases. Although endovascular stent placement is considered for recurrent stenosis, its indications are controversial.

Methods: We enrolled 282 patients who underwent pediatric LDLT in our department from May 2001 to September 2016. Read More

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http://dx.doi.org/10.1007/s00383-019-04551-9DOI Listing
November 2019
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Management of portal hypertension and ascites in polycystic liver disease.

Liver Int 2019 11 20;39(11):2024-2033. Epub 2019 Sep 20.

Department of Gastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Patients suffering from polycystic liver disease may develop Hepatic Venous Outflow Obstruction, Portal Vein Obstruction and/or Inferior Caval Vein Syndrome because of cystic mass effect. This can cause portal hypertension, leading to ascites, variceal haemorrhage or splenomegaly. For this review, we evaluate the evidence to provide clinical guidance for physicians faced with this complication. Read More

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http://dx.doi.org/10.1111/liv.14245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899472PMC
November 2019
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A novel model for quantification of immediate liver perfusion impairment after pancreatic islet transplantation.

Islets 2019 9;11(6):129-140. Epub 2019 Sep 9.

Laboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Instant Blood-Mediated Inflammatory Reaction (IBMIR) is a major cause of graft loss during pancreatic islet transplantation, leading to a low efficiency of this treatment method and significantly limiting its broader clinical use. Within the procedure, transplanted islets obstruct intrahepatic portal vein branches and consequently restrict blood supply of downstream lying liver tissue, resulting typically in ischemic necrosis. The extent of ischemic lesions is influenced by mechanical obstruction and inflammation, as well as subsequent recanalization and regeneration capacity of recipient liver tissue. Read More

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http://dx.doi.org/10.1080/19382014.2019.1651164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930024PMC
May 2020
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Extra Hepatic Portal Vein Obstruction with Solitary Left Kidney: A Case Report.

JNMA J Nepal Med Assoc 2019 Mar-Apr;57(216):130-132

Department of GI and General surgery, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Extra Hepatic Portal Vein Obstruction in individual with solitary left kidney is rare occurence. Though there is no etiological association between Extra Hepatic Portal Vein Obstruction and solitary left kidney but the solitary left kidney decides the modality of treatment. Eighteen year lady referred to our institute with menorrhagia for 5 years and ultrasonography finding of splenomegaly and atretic right kidney. Read More

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February 2020
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Extrahepatic Portal Venous Obstruction With Hepatic Enzyme Elevation Resembling Hepatitis in Patients With Cancer.

In Vivo 2019 Sep-Oct;33(5):1697-1702

Department of Medical Imaging and Intervention, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan, R.O.C.

Background/aim: Chemotherapy is often halted due to abnormal liver function resembling hepatitis. But the cause can be extrahepatic portal venous obstruction (EHPVO) with hepatic enzyme elevation rather than being an adverse effect of chemotherapy. We investigated EHPVO with hepatic enzyme elevation in patients with cancer. Read More

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http://dx.doi.org/10.21873/invivo.11658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755011PMC
February 2020

Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.

Chin Clin Oncol 2019 Aug 5;8(4):40. Epub 2019 Aug 5.

Department of Radiology, Division of Interventional Radiology, Weill Cornell Medicine, New York, NY, USA.

Gallbladder carcinoma is a rare, aggressive biliary tract malignancy, with a 5-year survival of less than 5%. It is the 6th most common gastrointestinal malignancy in the United States and more commonly found in women. While some risk factors include gallstones, porcelain gallbladder, and smoking, gallbladder carcinoma is often found incidentally following cholecystectomy or percutaneous image guided biopsy. Read More

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http://dx.doi.org/10.21037/cco.2019.07.09DOI Listing
August 2019
12 Reads

Fetal case of right atrial isomerism with infracardiac total anomalous pulmonary venous connection and agenesis of the ductus venosus.

J Obstet Gynaecol Res 2019 Nov 9;45(11):2275-2279. Epub 2019 Aug 9.

Department of Cardiology, Kanagawa Children's Medical Center, Yokohama, Japan.

After birth, the ductus venosus becomes an important route connecting the pulmonary and systemic venous systems for survival in infracardiac total anomalous pulmonary venous connection. We encountered a fetal case of right atrial isomerism with infracardiac total anomalous pulmonary venous connection and agenesis of ductus venosus. Prenatal echocardiography suggested that the fetus had severe pulmonary venous obstruction; however, no obstructive lesions were detected at the level of the vertical vein that drained into the portal veins. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.14088
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http://dx.doi.org/10.1111/jog.14088DOI Listing
November 2019
4 Reads

Budd-Chiari Syndrome With Spontaneous Intrahepatic Portosystemic Shunts: A Case Series.

J Clin Exp Hepatol 2019 May-Jun;9(3):412-415. Epub 2018 Aug 25.

Department of Gastroenterology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, 400012, India.

Intra-hepatic portal-venous collaterals are characteristic of Budd-Chiari syndrome (BCS) and are usually of small caliber and seen on Doppler. Creation of large portal-systemic shunt, either radiologically (Transjugular intrahepatic porto-systemic shunt) or surgically results in excellent long term outcomes in BCS. Here, we report a series of three rare cases of asymptomatic BCS, who had spontaneous large intra-hepatic portal-systemic shunts. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637088PMC
August 2018
2 Reads

Portal Hypertension of a Delayed Onset Following Liver Abscesses in a 12-Month-Old Infant: A Case Report and Review of the Literature.

Pediatr Gastroenterol Hepatol Nutr 2019 Jul 19;22(4):400-406. Epub 2019 Jun 19.

Department of Radiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

We report a 12-month-old female infant who had a history of neonatal sepsis with liver micro-abscesses that resolved with intravenous antibiotics during neonatal period. During her neonatal admission period, no umbilical vein catheter was inserted. Also, she did not undergo any abdominal surgeries or had a postnatal history of necrotizing enterocolitis. Read More

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http://dx.doi.org/10.5223/pghn.2019.22.4.400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629598PMC
July 2019
4 Reads