1,905 results match your criteria Portal Vein Obstruction

MiR-124 and miR-506 are involved in the decline of protein C in children with extra-hepatic portal vein obstruction.

Sci Rep 2021 Jun 10;11(1):12320. Epub 2021 Jun 10.

Department of General Surgery, Capital Institute of Pediatrics, No. 2 Yabaolu Rd., Beijing, 100020, People's Republic of China.

The deficiency of protein C (PROC) can be partly rescued by Rex shunt through restoring portal blood flow in children with extra-hepatic portal venous obstruction (EHPVO). However, the decline of PROC is still found in some patients with a normal portal blood flow after Rex shunt. The aim of this study was to identify the candidate miRNAs involving in the decline of PROC and their mechanism. Read More

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Portal vein obstruction after pediatric liver transplantation: A systematic review of current treatment strategies.

Transplant Rev (Orlando) 2021 May 29;35(4):100630. Epub 2021 May 29.

Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Introduction: Portal vein obstruction (PVO) is a significant vascular complication after liver transplantation (LT) in pediatric patients. Current treatment strategies include percutaneous transluminal angioplasty (PTA), with or without stent placement, mesorex bypass (MRB), splenorenal shunt, mesocaval shunt, endovascular recanalization (EVR), splenic artery embolization and splenectomy. However, specific characteristics of patients undergoing intervention and selection of individual treatment and its efficacy have remained unclear. Read More

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Chronic liver disease not a significant comorbid condition for COVID-19.

Sci Rep 2021 06 3;11(1):11734. Epub 2021 Jun 3.

Department of Diagnostic Imaging, Rhode Island Hospital, Philadelphia, PA, 19104, USA.

To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Read More

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Management problems in patients with pancreatic cancer from a surgeon's perspective.

Semin Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University, Halle-Wittenberg, Halle, Germany. Electronic address:

Pancreatic cancer is one of the most lethal gastrointestinal tumor entities. Surgery is the only chance for cure; however, only a minority of patients can be offered this option. Due to the anatomic location of the gland, tumor-related problems and complications affecting the surrounding structures are common, leading to biliary and gastric outlet obstruction as well as portal vein thrombosis. Read More

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Management of a rare case of extra hepatic portal vein obstruction with temporomandibular joint ankylosis and review of literature.

Ann Hepatobiliary Pancreat Surg 2021 May;25(2):283-286

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Extrahepatic portal venous obstruction (EHPVO) and temporomandibular joint (TMJ) ankylosisis are significant problems in Asian countries. Both EHPVO and bilateral TMJ ankylosis may have rare association due to protein C and S deficiency which may cause hypercoagulability as well as reduced fibrinolytic activity. Ankylosis arising in early childhood is associated with facial asymmetry, feeding difficulty and speech development alterations. Read More

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Angiographic diagnosis for accurate assessment of CPSS and EHPVO in children.

Pediatr Int 2021 May 28. Epub 2021 May 28.

Department of Cardiology, Shizuoka Children's Hospital.

Background: Congenital porto-systemic shunt (CPSS) is a rare disease and can cause fatal complications. Accurate angiographic assessment is mandatory for proper treatment. Although technically difficult, we developed assessment techniques and assessed their accuracy. Read More

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Hepatic portal vein gas detected by point of care ultrasound.

Int J Surg Case Rep 2021 May 12;83:105974. Epub 2021 May 12.

Critical Care Unit, Ahamdi Hospital, Kuwait Oil Company, Kuwait. Electronic address:

Introduction: Portal venous gas is a rare finding in adults and is typically associated with underlying intestinal ischemia. Portal venous gas can be detected by a bedside point of care ultrasound (POCUS) examination in adult patients in critical care units (CCU). Findings include echogenic bubbles flowing centrifugally throughout the portal venous system. Read More

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Jejunal varices with extra hepatic portal vein obstruction: A case report.

Int J Surg Case Rep 2021 May 12;83:105964. Epub 2021 May 12.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Introduction And Importance: Extrahepatic portal vein obstruction (EHPVO) with portal hypertension is rare in children. Intestinal varices as new collaterals accompanying portal hypertension are very rare.

Presentation Of Case: We report an unusual case of a 12-year-old boy with EHPVO with gastrointestinal bleeding from ectopic jejunal varices, without any gastroesophageal varices. Read More

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[Clinical study of causes and outcomes in pediatric liver retransplantation].

Zhonghua Wai Ke Za Zhi 2021 May;59(5):353-358

Organ Transplant Center, Tianjin First Central Hospital, Tianjin Key Laboratory for Organ Transplantation, Tianjin 300192, China.

To investigate the etiology,clinical features and prognosis of pediatric liver retransplantation. The data of 1 024 cases of pediatric liver transplantation (<18 years old) from January 2014 to December 2019 operated at Tianjin First Central Hospital were collected,retrospectively. Retransplantation was performed in 26 cases,among which 25 cases received secondary liver transplantation and 1 case received a third liver transplantation. Read More

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Andexanet Alfa Use for Small Bowel Obstruction Patient With History of Sugiura Procedure.

Mil Med 2021 Apr 22. Epub 2021 Apr 22.

Department of Anesthesiology, Naval Medical Center, San Diego, CA 92134, USA.

This case report is about a 51-year-old active duty male with JAK2 mutation and medical history significant for prehepatic portal hypertension from portal vein thrombus on lifelong anticoagulation with rivaroxaban, an oral factor Xa inhibitor, presenting with closed-loop small bowel obstruction requiring emergent laparotomy. We present this surgical case as it required emergent reversal of the oral factor Xa inhibitor with andexanet alfa. Read More

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Diagnosis and management of extrahepatic oesophageal variceal bleed in children in a low resourced setting.

Ghana Med J 2020 Dec;54(4):274-278

Department of Child Health, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra.

Extrahepatic portal vein obstruction (EHPVO) is a major cause of portal hypertension (PH) in children. Portal vein thrombosis (PVT) is the most common cause accounting for up to 75% of cases in developing countries. Upper gastrointestinal bleeding is the most dreaded and commonest presentation of portal hypertension. Read More

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December 2020

Comparison of unenhanced and contrast-enhanced 3 T magnetic resonance portovenography in children with extra hepatic portal venous obstruction.

Abdom Radiol (NY) 2021 Mar 30. Epub 2021 Mar 30.

Department of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To evaluate role of 3-T magnetic resonance portovenography (MRPV) in children with extra hepatic portal venous obstruction (EHPVO) and compare unenhanced and contrast-enhanced sequences.

Methods: 20 Children with EHPVO underwent MRPV using unenhanced [T2, T1 pre-contrast, Balanced turbo field echo (BTFE)] and contrast-enhanced (CE) modified DIXON (mDIXON) sequences. The images were evaluated for the patency of abdominal veins, hepatic and splenic parenchyma by two radiologists for interobserver agreement. Read More

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Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation.

Int J Hematol 2021 Jul 24;114(1):94-101. Epub 2021 Mar 24.

Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan.

Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). We previously reported the efficacy of the Hokkaido Ultrasonography (US)-based scoring system (HokUS-10) for US findings. To establish easier-to-use criteria, we retrospectively evaluated US findings from 441 patients, including 30 patients with SOS using the HokUS-10 scoring system. Read More

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A Nationwide Analysis of Budd-Chiari Syndrome in the United States.

J Clin Exp Hepatol 2021 Mar-Apr;11(2):181-187. Epub 2020 Aug 15.

Institute of Digestive Health & Liver Diseases, Mercy Medical Center, Baltimore, MD, USA.

Objective: The Budd-Chiari Syndrome (BCS) is a rare disorder characterized by hepatic venous outflow obstruction. The primary objectives of our study were to assess temporal trends in the prevalence of BCS among hospitalized patients in the United States using the National Inpatient Sample (NIS) database and to evaluate demographics, risk factors, and common presentation of BCS.

Methods: Data were extracted from the NIS to identify patients >18 years of age using all listed diagnosis of BCS from 1998 to 2017 and analyzed. Read More

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Predictors and risk factors for intestinal necrosis in patients with mesenteric ischemia.

Ann Transl Med 2021 Feb;9(4):337

Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Background: Mesenteric ischemia results in blood flow that is insufficient to meet metabolic demands and subsequent dysfunction of visceral organs, including arterial obstruction and venous thrombosis. Sustained mesenteric ischemia exhausts the ability of capillaries to provide oxygen and initiate an inflammatory reaction, and eventually leads to intestinal mucosal necrosis, a serious and potentially life-threatening condition. Therefore, it is essential that the predictors and risk factors for intestinal necrosis in patients with mesenteric thrombus are explored. Read More

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February 2021

Splenic vein stenting for recurrent chylous ascites in sinistral portal hypertension: a case report.

CVIR Endovasc 2021 Mar 3;4(1):26. Epub 2021 Mar 3.

Department of Radiology, Aventura Hospital & Medical Center, 20900 Biscayne Blvd, Aventura, FL, 33180, USA.

Background: Sinistral portal hypertension results from obstruction or stenosis of the splenic vein and is characterized by normal portal vein pressures and liver function tests. Gastrointestinal bleeding is the most common presentation and indication for treatment. Although sinistral portal hypertension-related chylous ascites is rare, several cases have described successful treatment with portal venous, rather than splenic venous, recanalization. Read More

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Laparoscopic Left Hepatectomy with Middle Hepatic Vein Resection for Hepatocellular Carcinoma with Extrahepatic Portal Vein Obstruction.

Am J Case Rep 2021 Mar 1;22:e928801. Epub 2021 Mar 1.

Department of Surgery, Iwate Medical University, Morioka, Iwate, Japan.

BACKGROUND Extrahepatic portal vein obstruction (EHPVO) is one of the most important diseases that causes pre-hepatic portal hypertension, and EHPVO sometimes develops cavernous transformation to maintain hepatopetal flow. In this report, we describe the first case of hepatocellular carcinoma (HCC) with EHPVO having underwent pure laparoscopic left hepatectomy with middle hepatic vein (MHV) resection. CASE REPORT A 70-year-old woman with a diagnosis of mixed-type HCC or cholangiocarcinoma located in segment 4b was referred to our hospital, and computed tomography revealed EHPVO with cavernous transformation. Read More

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Influence of portal vein occlusion on portal flow and liver elasticity in an animal model.

NMR Biomed 2021 Jun 25;34(6):e4498. Epub 2021 Feb 25.

ICube, CNRS UMR 7357, University of Strasbourg, Strasbourg, France.

Hepatic fibrosis causes an increase in liver stiffness, a parameter measured by elastography and widely used as a diagnosis method. The concomitant presence of portal vein thrombosis (PVT) implies a change in hepatic portal inflow that could also affect liver elasticity. The main objective of this study is to determine the extent to which the presence of portal occlusion can affect the mechanical properties of the liver and potentially lead to misdiagnosis of fibrosis and hepatic cirrhosis by elastography. Read More

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Multimodal treatment strategies for colorectal liver metastases.

Swiss Med Wkly 2021 Feb 15;151:w20390. Epub 2021 Feb 15.

Department of Surgery, Swiss Hepato-pancreato-biliary and Transplantation Centre, University Hospital Zurich, Switzerland.

Colorectal cancer is the third most common cancer worldwide. Half of CRC patients develop liver metastases during the course of the disease, with a 5-year survival rate close to zero in the absence of therapy. Surgical resection remains the only possible curative option, and current guidelines recommend adjuvant chemotherapy, resulting in a 5-year survival rate exceeding 50%. Read More

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February 2021

Portal hypertension caused by pancreatic cancer: Multidetector computed tomography diagnosis and multivariate analysis of variceal hemorrhage.

J Cancer Res Ther 2020 ;16(7):1672-1677

Department of Clinical Medicine, Medical College of Qingdao University; Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.

Context: Pancreatic cancer portal hypertension (PCPH) is a rare cause of gastrointestinal bleeding. This study retrospectively assessed gastrointestinal bleeding risk factors in 57 PCPH patients diagnosed via multidetector computed tomography (MDCT).

Materials And Methods: The data of patients with pancreatic cancer from January 2008 to January 2018 at Qingdao Municipal Hospital were reviewed. Read More

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January 2020

Risk factors of poor prognosis in patients with pyrrolidine alkaloid-induced hepatic sinusoidal obstruction syndrome after transjugular intrahepatic portosystemic shunt.

Hepatol Int 2021 Jan 28. Epub 2021 Jan 28.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321#, Zhongshan Road, Nanjing, 210008, Jiangsu, China.

Aims: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective method in treating patients with severe hepatic sinusoidal obstruction syndrome induced by pyrrolidine alkaloids (PA-HSOS). However, some patients still have poor postoperative prognosis. So, we aim to evaluate the predictors associated with poor outcomes in PA-HSOS patients receiving TIPS. Read More

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January 2021

High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data.

World J Gastroenterol 2020 Dec;26(48):7693-7706

Department of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.

Background: Coronavirus disease 2019 (COVID-19) disease can frequently affect the liver. Data on hepatic histopathological findings in COVID-19 is scarce.

Aim: To characterize hepatic pathological findings in patients with COVID-19. Read More

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December 2020

Transjugular intrahepatic portosystemic shunt for hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.

BMC Gastroenterol 2021 Jan 10;21(1):26. Epub 2021 Jan 10.

Department of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.

Background: To evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) on hepatic sinusoidal obstruction syndrome (HSOS) associated with consumption of Gynura segetum (GS).

Methods: We retrospectively reviewed 9 consecutive patients with GS-related HSOS who were refractory to supportive treatment and underwent TIPS at our institution between January 2014 and September 2019. The patients were evaluated for safety and efficacy, including TIPS complications and changes in portosystemic pressure gradient (PPG), ascites, total bilirubin, liver size and portal vein diameter. Read More

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January 2021

Ischemic jejunal stricture in patients with extrahepatic portal vein obstruction.

Indian J Gastroenterol 2021 Feb 6;40(1):82-87. Epub 2021 Jan 6.

Department of Radio-Diagnosis, All India Institute of Medical Sciences, Patna 801 507, India.

Ischemic jejunal stricture due to mesenteric vein thrombosis (MVT) rarely occurs in patients with extrahepatic portal vein obstruction (EHPVO). This is because the thrombus often occludes only a short segment of superior mesenteric vein adjacent to splenoportal confluence, facilitating development of collateral veins that protect bowel from ischemia. However, ischemic strictures can develop when the thrombus involves jejunal veins, venous arcades or vasa recta. Read More

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February 2021

Urgent intraoperative endovascular stent placement to resolve acute hepatic or portal venous obstruction during liver surgery: a case series.

Surg Case Rep 2021 Jan 6;7(1). Epub 2021 Jan 6.

Department of Surgery, Fujita Health University, 1-98, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: Acute obstruction of the hepatic vein (HV) or the portal vein (PV), particularly when it occurs during liver surgery, is potentially fatal unless repaired swiftly. As surgical interventions for this problem are technically demanding and potentially unsuccessful, other treatment options are needed.

Case Presentation: We report two cases of acute, surgically uncorrectable HV or PV obstruction during liver resection or living donor liver transplantation (LDLT), which was successfully treated with urgent intraoperative placement of endovascular stents using interventional radiology (IVR). Read More

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January 2021

Reliability of an ultrasonographical scoring system for diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease in patients with hematopoietic stem cell transplantation.

J Med Ultrason (2001) 2021 Jan 4;48(1):45-52. Epub 2021 Jan 4.

Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.

Purpose: Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a fatal complication after hematopoietic stem cell transplantation. We previously reported the usefulness of an ultrasonographical (US) scoring system, the Hokkaido US-based scoring system consisting of ten parameters (HokUS-10): (1) hepatomegaly in the left lobe and (2) right lobe, (3) dilatation of the main portal vein (PV), (4) hepatofugal flow in the main PV, (5) decreased velocity of the PV, (6) dilatation of the para-umbilical vein (PUV), (7) appearance of blood flow signal in the PUV, (8) gallbladder (GB) wall thickening, (9) ascites, and (10) increased resistive index of the hepatic artery, for the diagnosis of SOS/VOD. However, the reliability of this system among operators remains elusive. Read More

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January 2021

Surgical shunts for extrahepatic portal vein obstruction in pediatric patients: a systematic review.

HPB (Oxford) 2021 May 30;23(5):656-665. Epub 2020 Dec 30.

Department of Surgery, University of Southern California, 1510 San Pablo Street, Suite 200, Los Angeles, CA 90033, USA; Pediatric Liver Transplant Program, Children's Hospital of Los Angeles, 4650 Sunset Boulevard, MS #147, Los Angeles, CA 90027, USA; Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033, USA.

Background: Extrahepatic portal vein obstruction (EHPVO) causes portal hypertension in noncirrhotic children. Among surgical treatments, it is unclear whether the meso-Rex shunt (MRS) or portosystemic shunt (PSS) offers lower post-operative morbidity and superior patency over time. Our objective was to evaluate long-term outcomes comparing MRS and PSS for pediatric patients with EHPVO. Read More

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Cauda equina syndrome secondary to portal vein thrombosis: case report of favorable outcome with conservative treatment.

J Neurosurg Spine 2021 Jan 1:1-6. Epub 2021 Jan 1.

1Department of Neurosurgery, Ospedale di Circolo Fondazione Macchi-ASST Settelaghi; and.

Epidural varicosis is a rare though well-known cause of cauda equina syndrome (CES). Although inferior vena cava (IVC) obstruction is the most common finding in such cases, portal vein hypertension can lead to epidural venous plexus engorgement by means of lumbar portocaval shunt activation.A 40-year-old woman presented with right-sided sciatica, which progressed to right foot drop and a 3-day history of vesical tenesmus and fecal retention. Read More

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January 2021

Deportalization, Venous Congestion, Venous Deprivation: Serial Measurements of Volumes and Functions on Morphofunctional 99mTc-Mebrofenin SPECT-CT.

Diagnostics (Basel) 2020 Dec 23;11(1). Epub 2020 Dec 23.

Department of Radiology, St. Eloi Hospital, Montpellier University Hospital, 34090 Montpellier, France.

The objective was to assess the changes in regional volumes and functions under venous-impaired vascular conditions following liver preparation. Twelve patients underwent right portal vein embolization (PVE) ( = 5) or extended liver venous deprivation (eLVD, i.e. Read More

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December 2020