84,290 results match your criteria Portal Hypertension


Rare anatomic variation of the hepatic arterial blood supply: case report and literature review.

Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.

Department of General and Minimally Invasive Surgery, Centre Hospitalier de Luxembourg, 4, rue Ernest Barblé, 1210, Luxembourg City, Luxembourg.

Purpose: Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation.

Methods: We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction. Read More

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December 2018

Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

The Role of Anticoagulation in Treating Portal Hypertension.

Curr Hepatol Rep 2018 18;17(3):200-208. Epub 2018 Jun 18.

1Division of Gastroenterology, Azienda Ospedaliero-Universitaria di Modena and University of Modena and Reggio Emilia, Modena, Italy.

Purpose Of Review: To revise experimental and clinical data supporting a less traditional role of anticoagulation for treating portal hypertension in patients with cirrhosis.

Recent Findings: Portal hypertension is the main driver of complications such as ascites, variceal hemorrhage, and hepatic encephalopathy, with inflammation as a key component. The traditional view of cirrhosis as a pro-hemorrhagic condition has recently changed, prothrombotic complications being recognized as frequently as the hemorrhagic ones. Read More

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The multikinase inhibitor regorafenib decreases angiogenesis and improves portal hypertension.

Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More

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November 2018

Neuronal Constituents and Putative Interactions Within the Ellipsoid Body Neuropil.

Front Neural Circuits 2018 27;12:103. Epub 2018 Nov 27.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.

The central complex (CX) is a midline-situated collection of neuropil compartments in the arthropod central brain, implicated in higher-order processes such as goal-directed navigation. Here, we provide a systematic genetic-neuroanatomical analysis of the ellipsoid body (EB), a compartment which represents a major afferent portal of the CX. The neuropil volume of the EB, along with its prominent input compartment, called the bulb, is subdivided into precisely tessellated domains, distinguishable based on intensity of the global marker DN-cadherin. Read More

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November 2018

Portal Venous Interventions: How to Recognize, Avoid, or Get Out of Trouble in Transjugular Intrahepatic Portosystemic Shunt (TIPS), Balloon Occlusion Sclerosis (ie, BRTO), and Portal Vein Embolization (PVE).

Tech Vasc Interv Radiol 2018 Dec 29;21(4):267-287. Epub 2018 Jul 29.

Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, CA. Electronic address:

Portal venous interventions comprise a large portion of many Interventional Radiology practices today, and remain some of the more technically challenging cases in one's repertoire of procedures. The patients upon whom these procedures are performed are often critically ill, have decompensated disease, or are burdened with comorbid conditions such that they are poor surgical candidates. This leaves them with few options outside the care of Interventional Radiology. Read More

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December 2018

Image-Guided Biliary Interventions: How to Recognize, Avoid, or Get Out of Trouble.

Tech Vasc Interv Radiol 2018 Dec 30;21(4):249-254. Epub 2018 Jul 30.

Department of Interventional Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC.

Percutaneous biliary interventions have a well-established role in the management of hepatobiliary diseases. Good outcomes include recognizing and avoiding complications. This section will cover the "standard" technique of percutaneous biliary drainage, pearls to decrease the risk of problems, and approaches to treat those complications in patients undergoing percutaneous transhepatic cholangiography and percutaneous transhepatic biliary drainage. Read More

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December 2018

SETDB1 regulates SMAD7 expression for breast cancer metastasis.

BMB Rep 2018 Dec 14. Epub 2018 Dec 14.

Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, Republic of Korea; Department of Functional Genomics, Korea University of Science and Technology, Daejeon, 305-333, Republic of Korea.

Breast cancer (BRC) is the most invasive cancer in women. Although the survival rate of BRC is gradually increasing due to improved screening systems, development of novel therapeutic targets for inhibition of BRC proliferation, metastasis and recurrence have been constantly needed. Thus, in this study, we identified overexpression of SETDB1 (SET Domain Bifurcated 1), a histone methyltransferase, in RNA-seq data of BRC derived from TCGA portal. Read More

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December 2018

Prognostic significance of the degree of lymphatic vessel invasion in locally advanced, surgically resectable pancreatic head cancer: A single center experience.

Medicine (Baltimore) 2018 Dec;97(49):e13466

Department of Diagnostic Pathology, Jichi Medical University Hospital.

Little is known concerning the prognostic significance of the degree of lymphatic vessel invasion in pancreatic head cancer. To address this gap in knowledge, we retrospectively examined 60 patients with locally advanced, surgically resectable pancreatic head cancer who underwent pancreaticoduodenectomy and lymph node (LN) dissection.All cases were histopathologically diagnosed as ductal adenocarcinoma, stage II (25 pT3N0 cases, 35 pT3N1 cases). Read More

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December 2018

Apatinib for treating advanced intrahepatic cholangiocarcinoma after failed chemotherapy: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(49):e13372

Department of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Rationale: Intrahepatic cholangiocarcinoma (ICC) originates from the secondary branch of the bile duct and the intrahepatic bile duct epithelial cells, and is a rare pathological type of primary liver cancer. Recently, apatinib has been successfully used for a variety of malignancies.

Patient Concerns: A 23-year-old female was noted with intermittent right upper abdominal distension, abdominal pain, and vomiting after eating for more than 1 month. Read More

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December 2018

The impact of a comprehensive electronic patient portal on the health service use: an interrupted time-series analysis.

Eur J Public Health 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, IIS-Jimenez Diaz Foundation, Madrid, Spain.

Background: There is little empirical research on the potential benefit that electronic patient portals (EPP) can have on the care quality and health outcomes of diverse multi-ethnic international populations. The purpose of this study is to determine the extent to which an EPP was associated with improvements in health service use.

Methods: Using a quasi-experimental interrupted time-series approach, we assessed health service use before (April 2012-September 2015) and after (October 2015-December 2016) the implementation of a comprehensive EPP at four hospitals in Madrid, Spain. Read More

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December 2018

New Th17-specific therapeutic strategies for HIV remission.

Curr Opin HIV AIDS 2018 Dec 12. Epub 2018 Dec 12.

CHUM Research Centre.

Purpose Of The Review: This review highlights current knowledge on the dichotomous role played by T helper 17 cells (Th17)-polarized CD4 T cells in maintaining mucosal immunity homeostasis versus fueling HIV/simian immunodeficiency virus (SIV) replication/persistence during antiretroviral therapy (ART), with a focus on molecular mechanisms underlying these processes.

Recent Finding: Th17 cells bridge innate and adaptive immunity against pathogens at mucosal barrier surfaces. Th17 cells are located at portal sites of HIV/SIV entry, express a unique transcriptional/metabolic status compatible with viral replication, and represent the first targets of infection. Read More

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December 2018

Liver Repair and Regeneration after Ischemia/Reperfusion Injury is Associated with Prolonged Fibrosis.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgery and Institute for Military Medicine, University of Cincinnati, United States.

Liver recovery after hepatic ischemia/reperfusion (I/R) injury is characterized by clearance of dead tissue and its replacement with functional liver parenchyma. Previous reports have observed fibrosis after liver I/R. In order to determine if liver fibrosis after I/R was a pathologic consequence of the injury response, we assessed the development of liver fibrosis after I/R and its impact on subsequent insult. Read More

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December 2018

Association of an Electronic Health Record-Linked Glaucoma Medical Reminder With Patient Satisfaction.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: While dosing reminders for glaucoma medications have been shown to increase drug adherence, an outstanding limitation preventing broad adoption is difficulty linking reminders to medication in each patient's electronic health record (EHR).

Objective: To examine the feasibility of implementing an EHR-linked, automated reminder system for glaucoma medications and assess patient satisfaction with it.

Design, Setting, And Participants: In this prospective, cross-sectional study, patients receiving glaucoma medications were recruited from a university-based glaucoma clinic from April 2017 to January 2018. Read More

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December 2018

Perihilar Hepatectomy for Hepatolithiasis with Compressed Hilar Bile Duct Induced by Perihilar Hyperplasia of Liver.

J Invest Surg 2018 Dec 13:1-9. Epub 2018 Dec 13.

a Hepatobiliary Surgery Institute, Southwest Hospital , Army Medical University , Chongqing , China.

Background: Stone recurrence is a major problem limiting the effects of surgical treatment for hepatolithiasis. It was showed that hyperplasia of perihilar liver may compress the hepatic portal and cause deficient bile flow because of compressed hilar bile duct, thereby leading to the formation of bile stasis and precipitating stone recurrence. This retrospective study aimed to evaluate the efficiency of perihilar hepatectomy for hepatolithiasis with compressed hilar bile duct induced by perihilar hyperplasia of liver. Read More

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December 2018

Long-Term Management of Vascular Access Ports in Nonhuman Primates Used in Preclinical Efficacy and Tolerability Studies.

J Invest Surg 2018 Dec 13:1-12. Epub 2018 Dec 13.

a Department of Surgery, Preclinical Research Center , University of Minnesota , Saint Paul, MN, USA.

Vascular access ports (VAPs) are an essential tool for long-term vascular access in preclinical studies and disease modeling in non-human primates (NHPs). We retrospectively reviewed central (inferior vena cava, IVC) and portal VAP implantation with the maintenance at our center from 15 January 2010 to 31 January 2018. In total, 209 VAPs were implanted for long-term drug administration and sampling. Read More

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December 2018

Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats.

Exp Ther Med 2018 Dec 27;16(6):4765-4771. Epub 2018 Sep 27.

Department of Hepatobiliary Surgery, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

The aim of the present study was to investigate the characteristics and progression of intestinal injury at the anhepatic phase in portal hypertensive rats. A total of 120 healthy male Wistar rats were purchased, with 15 rats in the normal control group and 105 rats were assigned to establish a prehepatic portal hypertension model. The 105 model rats were further divided into seven treatment groups following ischemia-reperfusion. Read More

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December 2018

Effects of retrograde reperfusion on the intraoperative internal environment and hemodynamics in classic orthotopic liver transplantation.

BMC Surg 2018 Dec 12;18(1):115. Epub 2018 Dec 12.

Department of Hepatobiliary Surgery, Peking University People's Hospital, Xizhimen, Beijing, 100044, China.

Background: To investigate the effects of retrograde reperfusion on the intraoperative internal environment and hemodynamics in classic orthotopic liver transplantation (OLT).

Methods: Thirty patients were undergone classic OLT using retrograde reperfusion in our center. Blood sampling was done at different time points including: Before blood venting via the portal vein (PV), 10 mL of blood was collected from the inferior vena cava (T); During retrograde reperfusion through the inferior vena cava (IVC), 10 mL of blood was collected when the volume of blood venting reached 10 mL (T), 100 mL (T), and 200 mL (T), respectively. Read More

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December 2018

Optimized imaging of the lower abdomen and pelvic region in hepatocyte-specific MRI: evaluation of a whole-abdomen first-pass shuttle protocol in patients with neuroendocrine neoplasms.

Acta Radiol 2018 Dec 12:284185118817936. Epub 2018 Dec 12.

1 Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Gadoxetic acid (Gd-EOB) has shown its advantages in hepatic tumor evaluation besides its disadvantages in extrahepatic staging due to its short hemodynamic interval. This results in the dilemma of which contrast agent to choose for whole abdominal magnetic resonance imaging (MRI).

Purpose: To evaluate the achievable contrast of a shuttle protocol for Gd-EOB MRI with accelerated 3D-T1-weighted sequences enabling complete dynamic liver imaging plus first-pass pelvic imaging. Read More

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December 2018

Iron Oxide Nanoparticles Biodistribution in an Experimental Pig Model - A New Approach for Delivery and Imaging.

Curr Health Sci J 2015 Oct-Dec;41(4):333-338. Epub 2015 Dec 22.

Research Center of Gastroenterology and Hepatology of Craiova, Romania.

Iron oxide nanoparticles (IONs) are of great interest in medicine, with great potential for imaging diagnostics, as well as therapeutic. Biomedical applications of IONs have been suggested for magnetic resonance imaging (MRI), with two available contrast agents on the market. However, new developments in biocompatibility and biodistribution are necessary as many new physiochemical features of coatings have been proposed for a good safety profile. Read More

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December 2015

Genotoxic, Histopathological and Oxidative Stress Responses in Catfish, Clarias gariepinus, Exposed to Two Antifouling Paints.

J Health Pollut 2017 Dec 18;7(16):71-82. Epub 2017 Dec 18.

Environmental Toxicology and Pollution Management Laboratory, Department of Zoology, University of Lagos, Nigeria.

Background: Antifouling paints are enriched with biocides and employed in the maritime industry to protect moving and fixed surfaces from fouling activities of sea dwelling invertebrates. There is limited information on their effect on the non-target African catfish, Clarias gariepinus, a commonly consumed fish in Lagos.

Objectives: This study investigated the effects of two commonly used antifouling paints (Berger TBT-free (A/F783 (H)), reddish brown color and Silka Marine lead based paint, pale orange color) on a non-target catfish species, Clarias gariepinus. Read More

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December 2017

Biological alterations in renal and hepatic tissues by a novel gold (III) anti-cancerous compound.

Iran J Basic Med Sci 2018 Oct;21(10):1064-1072

Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Objectives: Newer organo-metallic, specifically gold (III) complexes with multiple ligands are currently being formulated with primary focus of having increased anti-cancerous properties and decreased cytotoxicity. In this study, histological toxicity profile of a newly formulated anti-cancerous gold (III) compound [trans-(±)-1,2-(DACH)Au]Cl Bis(trans-1,2-Diaminocyclohexane) was investigated by evaluation of kidney and liver tissues of rats treated by the compound.

Materials And Methods: This is a quasi-experimental study. Read More

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October 2018

Laparoscopic splenectomy: posterolateral approach in patients with liver cirrhosis and portal hypertension with platelet count lower than 1 × 10/l.

Wideochir Inne Tech Maloinwazyjne 2018 Dec 24;13(4):454-459. Epub 2018 Jul 24.

Department of Hepatobiliary Pancreatic Surgery, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.

Introduction: Laparoscopic splenectomy for massive splenomegaly secondary to liver cirrhosis and portal hypertension in patients with an extremely low platelet count (< 1 × 10/l) presents several challenges. The posterolateral laparoscopic splenectomy approach may be a feasible and safe technique for these patients.

Aim: To evaluate the feasibility and safety of the posterolateral laparoscopic splenectomy approach in patients with platelet counts < 1 × 10/l secondary to liver cirrhosis and portal hypertension. Read More

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December 2018

Body motion during dynamic couch tracking with healthy volunteers.

Phys Med Biol 2018 Nov 23. Epub 2018 Nov 23.

Department of Radiation Oncology, University Hospital Zurich, Zurich, SWITZERLAND.

Introduction: In precision radiotherapy, the intrafractional motion can cause a considerable uncertainty of the location of the tumor to be treated. An established approach is the expansion of the target volume to account for the motion. An alternative approach is couch tracking, in which the patient is continually moved to compensate the intrafractional motion. Read More

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November 2018

Accuracy of iodine density thresholds for the separation of vertebral bone metastases from healthy-appearing trabecular bone in spectral detector computed tomography.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Institut für Diagnostische und Interventionelle Radiologie, Uniklinik Köln, Kerpener Str. 62, 50935, Köln, Germany.

Purpose: To evaluate quantitative iodine density mapping (IDM) with spectral detector computed tomography (SDCT) as a quantitative biomarker for separation of vertebral trabecular bone metastases (BM) from healthy-appearing trabecular bone (HTB).

Materials And Methods: IRB-approved retrospective single-center-study of portal venous SDCT datasets acquired between June 2016 and March 2017. Inclusion of 43 consecutive cancer patients with BM and 40 without. Read More

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December 2018

Classification of the transverse pattern of Mason II radial head fractures and its usefulness in arthroscopic osteosynthesis. Anatomo-surgical study.

Rev Esp Cir Ortop Traumatol 2018 Dec 3. Epub 2018 Dec 3.

Servicio de Cirugía Ortopédica y Traumatología, Hospital Clínico, Barcelona, España.

Objective: The management of MasonII fracture pattern assisted by arthroscopy is a valid technique that provides good results. The objective of this study was to draw attention to the usefulness of the location of the fracture in the head of the radius in defined quadrants with respect to the bicipital tuberosity through CT. This would help to plan the optimal forearm position to access each quadrant and foresee the specific difficulties of each one. Read More

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December 2018

An Intraoperative Portal Vein Flow > 123 mL/min Per 100 g Predicts a Better Survival of Patients After Liver Transplantation.

Transplant Proc 2018 Jun 30. Epub 2018 Jun 30.

HPB and Liver Transplant Unit, University Hospital, Vírgen del Rocío, Seville, Spain. Electronic address:

Objective: To assess the importance of intraoperative portal vein flow measurement during liver transplantation in relation to postoperative complications and graft and patient survival.

Materials And Methods: Retrospective review including 291 patients who had all the information and covering a period of 10 years (2007-2017). Using a receiver operating characteristic curve, a cut-off point that would have the greatest impact on the probability of being alive at 5 years was established. Read More

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Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma.

BMC Cancer 2018 Dec 6;18(1):1221. Epub 2018 Dec 6.

Department of Internal Medicine, Yonsei Univeristy College of Medicine, 4th Floor Research Center for Future Medicine, 63-Gil 20, Eonju-ro, Gangnam-gu, Seoul, Republic of Korea.

Background: A subset of lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutations (mEGFR) is common in non-smokers and women, suggesting that mutational stressors other than smoking are involved.

Methods: Targeted sequencing using a custom panel containing 70 cancer-related genes were performed from 73 cases of lung adenocarcinoma with mEGFR (study cohort). In parallel, publicly available data of 47 TCGA-LUAD cases with mEGFR (LUAD cohort) were extracted from the GDC data portal and analyzed by non-negative matrix factorization using the Maftools package. Read More

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December 2018

Communicating with Vulnerable Patient Populations: A Randomized Intervention to Teach Inpatients to Use the Electronic Patient Portal.

Appl Clin Inform 2018 Oct 12;9(4):875-883. Epub 2018 Dec 12.

University of California, Los Angeles, California, United States.

Background:  Patient portals are expanding as a means to engage patients and have evidence for benefit in the outpatient setting. However, few studies have evaluated their use in the inpatient setting, or with vulnerable patient populations.

Objective:  This article assesses an intervention to teach hospitalized vulnerable patients to access their discharge summaries using electronic patient portals. Read More

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October 2018

Correlation and prognostic accuracy between noninvasive liver fibrosismarkers and portal pressure in cirrhosis: Role of ALBI score.

PLoS One 2018 12;13(12):e0208903. Epub 2018 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: The role of noninvasive liver fibrosis markers which were developed to evaluate the severity of chronic liver disease remains unclear in cirrhosis.

Aims: To evaluate the correlation between noninvasive markers and hemodynamic parameters and their prognostic performance in cirrhotic patients.

Methods: A total of 242 cirrhotic patients undergoing hemodynamic study were analyzed. Read More

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December 2018

[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):280-284

Facultad de Medicina Humana, Universidad Nacional San Luis Gonzaga. Ica, Perú; Sociedad Científica de Estudiantes de Medicina de Ica (SOCEMI). Ica, Perú.

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is suffering from chronic pain in the left hypochondrium with episodes of bleeding for 3 years and sensation of thermal rise, physical examination revealed jaundice and massive splenomegaly, without neurological involvement. Severe osteoporosis, pancytopenia, and the presence of portal vein thrombosis with cavernomatous transformation complicated by portal biliopathy simulating a klatskin tumor, marrow and enzymatic studies were compatible with Gaucher disease, were shown as unexpected findings. Read More

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December 2018

The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Pediatric Gastroenterology, Hepatology and Nutrition, Atatürk University, Erzurum, Turkey.

Objectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify demographic and clinical features with a prospective, multicenter, cross-sectional study.

Methods: Patients (aged 3 months-18 years) who had unexplained transaminase elevation, unexplained hepatomegaly or hepatosplenomegaly, obesity-unrelated liver steatosis, biopsy-proven cryptogenic fibrosis and cirrhosis, or liver transplantation for cryptogenic cirrhosis were enrolled. Read More

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December 2018
1 Read

[Liver bud transplantation in rats].

Magy Seb 2018 Dec;71(4):163-169

Department of Organ Fabrication, Keio University School of Medicine 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Introduction: Research has made progress in organ fabrication using an extracellular matrix, cell sheets, or organoids. Human liver tissue has been constructed using a 3-dimensional (3D) bioprinter and showed evidence that an in vitro generated liver bud was reformed in a rodent liver model. This study describes the stages of development of rat fetal organs and liver structure and reviews recent progress in liver organoid transplantation. Read More

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December 2018

The effect of leisure coping on depressive symptoms among individuals with depression: examination of potential confounding effects of physical activity and extraversion.

Psychol Health Med 2018 Dec 12:1-13. Epub 2018 Dec 12.

c School of Public Health , Indiana University , Bloomington , IN , USA.

Clinically significant depression has been consistently identified as a phenomenon directly linked to stress and stress coping. Leisure behavior as purposeful coping strategy (i.e. Read More

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December 2018

Treatment strategy for huge hepatocellular carcinoma with intrahepatic metastasis and macrovascular invasion: a case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1233-S1236

Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Macrovascular invasion, such as tumor thrombus in the major portal vein (mPVTT) or major hepatic vein (mHVTT), is regarded as indicative of an advanced stage of hepatocellular carcinoma (HCC). To date, no effective treatment has been established for this kind of HCC. We herein present a case of huge HCC with intrahepatic metastasis, mPVTT, and mHVTT. Read More

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December 2018

Actual 5-Year Survivors After Surgical Resection of Hilar Cholangiocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Stanford University, Stanford, CA, USA.

Background: The prevalence and characteristics of actual 5-year survivors after surgical treatment of hilar cholangiocarcinoma (HC) have not been described previously.

Methods: Patients who underwent resection for HC from 2000 to 2015 were analyzed through a multi-institutional registry from 10 U.S. Read More

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December 2018
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Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

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December 2018

Correction to: Effectiveness of a SCERTS Model-Based Intervention for Children with Autism Spectrum Disorder (ASD) in Hong Kong: A Pilot Study.

Authors:
Lu Yu Xiaoqin Zhu

J Autism Dev Disord 2018 Dec 11. Epub 2018 Dec 11.

Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hunghom, Hong Kong, People's Republic of China.

The article Effectiveness of a SCERTS Model-Based Intervention for Children with Autism Spectrum Disorder (ASD) in Hong Kong: A Pilot Study, written by Lu Yu and Xiaoqin Zhu was originally published electronically on the publisher's internet portal (currently SpringerLink) on June 15, 2018 without open access. Read More

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December 2018

Pancreatic neuroendocrine tumors: MR imaging features preoperatively predict lymph node metastasis.

Abdom Radiol (NY) 2018 Dec 11. Epub 2018 Dec 11.

Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Purposes: Predictive factors of lymph node metastasis (LNM) in pancreatic neuroendocrine tumors (pNETs) are not well established. We sought to identify the value of MR imaging features in preoperatively predicting the lymph node metastasis of pNETs.

Materials And Methods: In this study, we enrolled 108 consecutive patients with pNETs between January 2009 and June 2018. Read More

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December 2018

[Life-threatening bleeding from ileal conduit venous varices in a patient with portal hypertension].

Urologe A 2018 Dec 11. Epub 2018 Dec 11.

Radiologische Klinik, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.

Life-threatening bleeding from portosystemic varices is a feared complication of portal hypertension. Particularly, varices in atypical locations-so-called ectopic varices-pose a challenge for diagnosis and therapy. In the present article, we describe the case of a patient with liver cirrhosis and recurrent bleeding from an ileal conduit resulting from peristomal varicosis. Read More

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December 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

Clinical Impact and Safety of Anticoagulants for Portal Vein Thrombosis in Cirrhosis.

Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical and Surgical Sciences, University of Bologna, Azienda Ospedaliero Universitaria S.Orsola Malpighi, Bologna, Italy.

Objectives: Portal vein thrombosis (PVT) is a frequent complication of cirrhosis. Benefit, safety, and duration of anticoagulant treatment in this setting are controversial issues. The aim of this study was to analyze the course of PVT in a large cohort of cirrhotic patients undergoing or not anticoagulation therapy. Read More

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December 2018

Portal vein embolization DOES not AFFECT the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study.

Int J Surg 2018 Dec 8. Epub 2018 Dec 8.

Service de chirurgie hépatobiliaire et pancréatique et de transplantation, Département de chirurgie, Centre Hospitalier de l'Université de Montréal, Site St-Luc, Montréal, QC, Canada.

Background: Previous studies comparing the survival outcomes of liver resections with and without preoperative portal vein embolization (PVE) for colorectal liver metastases (CLM) have linked PVE to higher rate of tumor progression, lower overall survival (OS) and lower disease-free survival (DFS). The lack of adjusted models to compare these outcomes is a limitation of these studies since patients requiring PVE may differ significantly from the ones receiving upfront surgery.

Materials And Methods: Prospective cohort study of 128 patients undergoing CLM resection. Read More

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December 2018

Contrast-enhanced ultrasonography is a feasible technique for quantifying hepatic microvascular perfusion in dogs with extrahepatic congenital portosystemic shunts.

Vet Radiol Ultrasound 2018 Dec 9. Epub 2018 Dec 9.

Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan.

Extrahepatic-congenital portosystemic shunt is a vascular anomaly that connects the portal vein to the systemic circulation and leads to a change in hepatic microvascular perfusion. However, an assessment of hepatic microvascular perfusion is limited by conventional diagnostic modalities. The aim of this prospective, exploratory study was to assess hepatic microvascular perfusion in dogs with extrahepatic-congenital portosystemic shunt using contrast-enhanced ultrasonography (CEUS) using perfluorobutane (Sonazoid ). Read More

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December 2018

Contrast-Enhanced Ultrasound for identifying circulatory complications after liver transplants in children.

Pediatr Transplant 2018 Dec 7:e13327. Epub 2018 Dec 7.

Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Our main goal with this study was to share our off-label experience with CEUS for identifying circulatory complications after liver transplantation in children. A total of 74 CEUS examinations performed on 34 pediatric patients who underwent a liver transplant were retrospectively included. About 53% of the examinations were performed on children 2 years old or younger. Read More

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December 2018

Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).

Cochrane Database Syst Rev 2018 Dec 11;12:CD011594. Epub 2018 Dec 11.

Faculty of Medicine, SEGi University, Hospital Sibu, Jalan Ulu Oya, Sibu, Sarawak, Malaysia, 96000.

Background: Several dual bronchodilator combinations of long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS). Fixed-dose combination (FDC) of aclidinium/formoterol is one of the approved LABA/LAMA therapies for people with stable COPD. Read More

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December 2018

EPID-based in vivo dosimetry using Dosimetry Check™: Overview and clinical experience in a 5-yr study including breast, lung, prostate, and head and neck cancer patients.

J Appl Clin Med Phys 2018 Dec 7. Epub 2018 Dec 7.

Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK.

Background: Independent verification of the dose delivered by complex radiotherapy can be performed by electronic portal imaging device (EPID) dosimetry. This paper presents 5-yr EPID in vivo dosimetry (IVD) data obtained using the Dosimetry Check (DC) software on a large cohort including breast, lung, prostate, and head and neck (H&N) cancer patients.

Material And Methods: The difference between in vivo dose measurements obtained by DC and point doses calculated by the Eclipse treatment planning system was obtained on 3795 radiotherapy patients treated with volumetric modulated arc therapy (VMAT) (n = 842) and three-dimensional conformal radiotherapy (3DCRT) (n = 2953) at 6, 10, and 15 MV. Read More

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December 2018
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Correction to: Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer.

Target Oncol 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.

The article Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer, written by Sarah Sammons, Noah S. Kornblum and Kimberly L. Blackwell, was originally published electronically on the publisher's internet portal (currently SpringerLink). Read More

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December 2018