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Homeopathy 2019 Apr 20. Epub 2019 Apr 20.

Laboratoire d'Hématologie, UFR des Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France.

Background:  Aspirin is the oldest and possibly the most widely used pharmacologically active substance still used in allopathic medicine. Its effect on fever and inflammation has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested for many years in the University of Bordeaux, in humans as well as in animal models. Read More

Transpl Infect Dis 2019 Apr 19:e13097. Epub 2019 Apr 19.

Hepatobiliary Surgery and Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.

Endotipsitis is a rare but severe complication of transjugular intrahepatic portosystemic shunt (TIPS), a device widely used to treat portal hypertension in adults, but sparsely used in children. We report a case of endotipsitis in a 3-year-old child affected of biliary atresia. She underwent a Kasai procedure at 3 months of age but, although the bile flow was restored, she presented upper gastrointestinal bleeding due to portal hypertension 1. Read More

Case Rep Obstet Gynecol 2019 14;2019:5702983. Epub 2019 Mar 14.

Department of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.

Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. Read More

BMC Nephrol 2019 Apr 18;20(1):132. Epub 2019 Apr 18.

Geisinger Health System, Department of Nephrology, 100 N Academy Ave, Danville, PA17822, USA.

Background: Proteinuria screening is recommended for patients with hypertension to screen for kidney disease and identify those at elevated risk for cardiovascular disease. However, screening rates among hypertensive patients are low. Home testing strategies may be useful in improving proteinuria screening adherence. Read More

Br J Surg 2019 Apr 16. Epub 2019 Apr 16.

National Centre for Global Health and Medicine, Tokyo, Japan.

Background: Indications for hepatectomy in patients with hepatocellular carcinoma (HCC) who have portal hypertension (PH) have been controversial. Some studies have concluded that PH is a contraindication to hepatectomy, whereas others have suggested that perioperative prophylactic management (PPM) can help overcome complications after hepatectomy associated with PH. The objective of this retrospective study was to assess the short- and long-term outcomes after hepatectomy for HCC in patients with PH, with or without PPM. Read More

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Academic Department of Gastroenterology, Laiko General Hospital, Medical School of National, Kapodistrian University of Athens, 17 Aghiou Thoma, 11527, Athens, Greece.

Background And Aim: To evaluate if spleen stiffness measurement (SSM) can rule out the presence of high-risk varices in patients with cirrhosis, avoiding an upper gastrointestinal endoscopy (UGE).

Methods: We enrolled 71 cirrhotic patients irrespective of liver disease's etiology. 2D shear wave elastography (SWE) of spleen and UGE was performed. Read More

Cells 2019 Apr 4;8(4). Epub 2019 Apr 4.

Gastroenterology Unit, Università di Torino, 10124Torino, Italy.

In clinical trials, a sofosbuvir/velpatasvir (SOF/VEL) pangenotypic single-tablet regimen was associated with high sustained virological response (SVR) rates at 12 weeks (SVR12) after the end of treatment, regardless of genotype and fibrosis stage. No real-life data on genotype 3 (GT3) cirrhotic patients with portal hypertension are available. The aim of this study was to assess the effectiveness of SOF/VEL in GT3 cirrhotics with portal hypertension. Read More

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Digestive Disease Department, Marqués de Valdecilla University Hospital, Cantabria University, 39008 Santander, Spain.

The concept of liver fibrosis and cirrhosis being static and therefore irreversible is outdated. Indeed, both human and animal studies have shown that fibrogenesis is a dynamic and potentially reversible process that can be modulated either by stopping its progression and/or by promoting its resolution. Therefore, the study of the molecular mechanisms involved in the pathogenesis of liver fibrosis is critical for the development of future antifibrotic therapies. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15168

Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

A precise and noninvasive method to predict posthepatectomy liver failure (PHLF) in clinical practice is still lacking. Liver fibrosis or cirrhosis accompanied with varying degrees of portal hypertension plays an important role in the occurrence of PHLF in hepatocellular carcinoma (HCC) patients. This study aims to compare the predictive ability of the albumin-bilirubin score to spleen thickness ratio (ALBI/ST) versus fibrosis-4 index (FIB-4) and aspartate aminotransferase to platelet count ratio index (ARPI) for the occurrence of PHLF. Read More

Gastrointest Endosc 2019 Apr 10. Epub 2019 Apr 10.

Royal Free Unit for Endoscopy, The Royal Free Hospital and University College London (UCL) Institute for Liver and Digestive Health, Hampstead, London, United Kingdom.

Background And Aims: Small-bowel varices (SBV) are an uncommon consequence of portal hypertension. Radiological intervention (RI) is usually considered for first-line management. When RI is not possible, management options become very limited. Read More

Int J Health Policy Manag 2018 Nov 4;8(2):112-123. Epub 2018 Nov 4.

Chronic Disease and Wellness, Nova Scotia Health Authority, Halifax, NS, Canada.

Background: Understanding and addressing the needs of frail patients has been identified as an important strategy by the Nova Scotia Health Authority (NSHA). Primary care (PC) providers are in a key position to aid in the identification of, and response to frailty as part of routine care. Unlike singular chronic conditions such as diabetes and hypertension which garner a disease-based approach and identification as part of standard practice, frailty is only just emerging as a concept for PC. Read More

Liver Transpl 2019 Apr 13. Epub 2019 Apr 13.

Department of General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.

Hepatic venous pressure gradient (HVPG) is known to correlate with severity of portal hypertension in patients with liver cirrhosis. This retrospective study investigated the clinical value of preoperative measurement of HVPG in patients who underwent adult-to-adult LDLT and its predictive value for hepatic hemodynamics after graft reperfusion. For this study, seventy-five patients who underwent adult-to-adult LDLT were divided into two groups (HVPG < 16 mmHg or HVPG > 16 mmHg) to investigate the correlation between preoperative HVPG and characteristics and surgical outcomes of the patients, including portal vein flow (PVF) and hepatic artery flow (HAF) after graft reperfusion. Read More

Clin J Gastroenterol 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, 19102, USA.

Liver cirrhosis is associated with multiple vascular syndromes affecting almost all body systems. Many of these syndromes are directly related to impaired liver function and sometimes reversible after liver transplantation while others arise secondary to portal hypertension and ascites. Altered expression of angiogenic and vasoactive compounds (most importantly nitric oxide), endothelial dysfunction, dysregulated neurohormonal control, and systemic inflammatory state play differential roles in mediating homeostatic instability and abnormal vasogenic response. Read More

Transplant Proc 2019 Apr 7;51(3):790-793. Epub 2019 Jan 7.

Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, USA. Electronic address:

Cystic fibrosis (CF) is caused by a mutation in the CF transmembrane conductance regulator (CFTR) gene, deranging the activity of chloride channels on the epithelial cell surface. Herein we describe end-stage liver disease in 3 infants with rare CFTR gene mutations; 2 of them were heterozygous. Case 1 was a premature male infant with negative CF screening at birth who developed a small bowel obstruction in the neonatal period requiring an ileostomy, with subsequent cholestatic liver disease and portal hypertension. Read More

Transl Gastroenterol Hepatol 2019 20;4:13. Epub 2019 Feb 20.

Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang 110840, China.

Acute variceal hemorrhage (AVH) is a devastating complication of liver cirrhosis. Endoscopic variceal ligation (EVL) is a useful endoscopic treatment for AVH with few complications. However, the issue regarding management of early re-bleeding after EVL still needs to be concerned. Read More

SAGE Open Med Case Rep 2019 1;7:2050313X19838946. Epub 2019 Apr 1.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Gastroesophageal variceal hemorrhage is a substantial cause of death in patients with portal hypertension. Cyanoacrylate injection is a widely used endoscopic treatment for variceal hemorrhage. We report herein the case of a 49-year-old male with decompensated alcoholic cirrhosis, who received endoscopic sclerotherapy to stop gastroesophageal variceal hemorrhage during hospitalization. Read More

World J Hepatol 2019 Mar;11(3):250-260

South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, PL68DH, United Kingdom.

Gastric varices (GV) have different physiology and clinical characteristics compared to oesophageal varices (OV). There is little information about the management of GV. Most part of the recommendations is extrapolated from studies where the majority of participants had OV. Read More

Chirurg 2019 Apr 8. Epub 2019 Apr 8.

Klinik und Poliklinik für Allgemein‑, Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum der Rheinischen Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.

Background: Esophageal variceal bleeding is a life-threatening complication in patients with liver cirrhosis, which is pathophysiologically explained by the presence of portal hypertension. The incidence of such bleeding greatly depends on the severity of the underlying liver disease.

Objective: The aim of this article is to present the current treatment concepts for acute esophageal variceal bleeding, the management in acute situations and the indications for treatment of the causal portal hypertension with a transjugular intrahepatic portosystemic shunt (TIPS). Read More

Lancet Gastroenterol Hepatol 2019 May;4(5):399-411

Barcelona Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain; CIBER Hepatic and Digestive Diseases, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Portal hypertension in the absence of portal vein thrombosis and without cirrhosis, but with mild or moderate alterations of liver histology (eg, obliterative venopathy, nodular regenerative hyperplasia, or incomplete septal cirrhosis) is being increasingly recognised. Owing to the heterogeneity of causes and histological findings, a substantial number of terms have been used to describe such idiopathic non-cirrhotic portal hypertension. Patients with the same clinical and histological features exist, but without portal hypertension at the time of diagnosis. Read More

Hepatology 2019 Apr 5. Epub 2019 Apr 5.

Indiana University, Medicine.

We appreciate the interest and the thoughtful response by Gioia et al. on our recent observations about the liver stiffness measurement in patients with non-cirrhotic portal hypertension (NCPH). The causes of NCPH are myriad and can be prehepatic, hepatic or post hepatic. Read More

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia.

Common variable immune deficiency (CVID) is a primary immunodeficiency disorder that is associated with abnormal liver function tests, however advanced liver disease is uncommon. Hepatopulmonary syndrome (HPS) is a rare but debilitating complication of CVID-associated liver disease. We report a case of CVID complicated by HPS that was successfully treated with orthotopic liver transplant, with the patient recovering to normal hepatic function and successfully weaning off domiciliary oxygen post-transplantation. Read More

Clin Liver Dis 2019 May 21;23(2):263-277. Epub 2019 Feb 21.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9B-16, MSC 1800, Bethesda, MD 20892, USA. Electronic address:

Cystic fibrosis liver disease (CFLD) remains the third leading cause of death in patients with cystic fibrosis. Although most patients with CFLD present in childhood, recent studies suggest a second wave of liver disease in adulthood. There are no clear guidelines for diagnosing CFLD. Read More

Mayo Clin Proc 2019 Apr;94(4):714-726

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

Portal hypertension is a major complication of cirrhosis, and its consequences, including ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to substantial morbidity and mortality. The past several decades have seen major improvements in the clinical management of complications of portal hypertension, resulting in substantial gains in patient outcomes. However, important challenges remain. Read More

Am Surg 2019 Mar;85(3):e179-e181

Hepatology 2019 Apr 4. Epub 2019 Apr 4.

Universita di Roma La Sapienza, Dipartimento di Medicine Clinica.

We thank Yu-Jen Chen and Andrew M. Moon for their interest in our study . Their comments are extremely stimulating and appropriate. Read More

Hepatol Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Public Health, Jichi Medical University, Tochigi, Japan.

Aim: Idiopathic portal hypertension (IPH), extrahepatic portal obstruction (EHO), and Budd Chiari syndrome (BCS) are characterized by aberrant portal hemodynamics of unknown etiology. The aim of this study was to explore trends in the descriptive epidemiology of these diseases through periodical nationwide surveys.

Methods: Nationwide epidemiologic surveys were conducted in 1999, 2005, and 2015 using the same protocol. Read More

J Clin Transl Hepatol 2019 Mar 12;7(1):3-8. Epub 2018 Nov 12.

Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.

Studies have indicated that serum von Willebrand factor (vWF) has a positive correlation with hepatic venous pressure gradient. However, information on the value of vWF in the diagnosis of liver cirrhosis with portal hypertension has been lacking. The purpose of this meta-analysis was to assess the value of vWF in the diagnosis of liver cirrhosis with portal hypertension. Read More

JAMA Surg 2019 Apr 3. Epub 2019 Apr 3.

Division of Interventional Radiology, Department of Radiology, University of California at Los Angeles Medical Center, David Geffen School of Medicine at University of California, Los Angeles.

Importance: Varices are one of the main clinical manifestations of cirrhosis and portal hypertension. Gastric varices are less common than esophageal varices but are often associated with poorer prognosis, mainly because of their higher propensity to bleed.

Observations: Currently, treatments used to control and manage gastric variceal bleeding include β-blockers, endoscopic injection sclerotherapy, endoscopic variceal ligation, endoscopic variceal obturation, shunt surgery, transjugular intrahepatic portosystemic shunts, balloon-occluded retrograde transvenous obliteration (BRTO), and modified BRTO. Read More

Clin Gastroenterol Hepatol 2019 Mar 30. Epub 2019 Mar 30.

Department of Gastroenterology, University Hospital Freiburg, Freiburg, Germany.

Background & Aims: We studied effects of diameter of covered, self-expandable nitinol stents on survival times of patients with a transjugular intrahepatic portosystemic shunt (TIPS).

Methods: We collected data from 185 patients (median age, 55 years; 30% female) who received a covered nitinol stent, from February 2006 through September 2010, using the online, multicenter, German TIPS registry. TIPS were given to 107 patients for refractory ascites and to 78 patients for variceal bleeding. Read More

J Gastroenterol Hepatol 2019 Mar 14. Epub 2019 Mar 14.

Hepatology Department, National Liver Institute, University of Menoufia, Shebeen El-Kom, Egypt.

Background And Aim: Upper gastrointestinal bleeding (UGIB) is a serious complication of portal hypertension in cirrhotic patients. The objective of this study is to identify the risk factors for morbidity and mortality occurring after an UGIB attack.

Methods: A total of 1097 UGIB attacks in 690 patients with liver cirrhosis were studied. Read More

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Faculté de Médecine Pierre et Marie Curie and Department of Radiology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 184 Rue du Faubourg Saint-Antoine, 75012, Paris, France.

This review shows the images obtained with non-contrast MR lymphography in different pathologic conditions affecting the liver. Non-contrast MR lymphography is obtained with a free-breathing 3D high spatial resolution fast-recovery fast spin-echo sequence similar to that used for 3D MR cholangiopancreatography. The liver is the largest lymph-producing organ generating approximately half of the body's lymphatic fluid and is the most important part of the lymphatic system from a functional point of view. Read More

J Clin Med 2019 Mar 27;8(4). Epub 2019 Mar 27.

Liver Unit, Austin Health, Melbourne 3084, Australia.

Introduction: Recent animal studies have shown that the alternate renin-angiotensin system (RAS) consisting of angiotensin-converting enzyme 2 (ACE2), angiotensin-(1⁻7) (Ang-(1⁻7)) and the Mas receptor is upregulated in cirrhosis and contributes to splanchnic vasodilatation and portal hypertension. To determine the potential relevance of these findings to human liver disease, we evaluated its expression and relationship to the patients' clinical status in subjects with cirrhosis.

Methods: Blood sampling from peripheral and central vascular beds was performed intra-operatively for cirrhotic patients at the time of liver transplantation (LT) or trans-jugular intra-hepatic portosystemic shunt (TIPS) procedures to measure angiotensin II (Ang II) and Ang-(1⁻7) peptide levels and ACE and ACE2 enzyme activity. Read More

Pediatr Transplant 2019 Apr 1:e13387. Epub 2019 Apr 1.

Division of Gastroenterology and Hepatology, Department of Pediatrics, University of Washington School of Medicine/Seattle Children's Hospital, Seattle, Washington.

Introduction: Indications for TIPS are well described in adults and involve complications of PHTN. Complications from PHTN are associated with PSG of > 12 mm Hg in adults. It is unclear if these parameters apply to children with PHTN. Read More

BJR Case Rep 2018 Dec 10;4(4):20180006. Epub 2018 Jul 10.

Department of Radiology, Good Hope Hospital, Birmingham, UK.

Intussusception of the gastrointestinal viscera is rarely encountered in adult patients and is frequently associated with a polypoidal lead point, which is often malignant. We would like to present the case of a 68-year-old male with a history of decompensated liver disease and multiple medical comorbidities, who was discovered to have an incidental gastrogastric intussusception on CT. No polypoidal lead point was seen and we believe this to be the first case of its kind to be described. Read More

Acad Radiol 2019 Mar 28. Epub 2019 Mar 28.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China. Electronic address:

Rationale And Objectives: To investigate whether quantitative radiomics features extracted from computed tomography (CT) can predict microsatellite instability (MSI) status in an Asian cohort of patients with stage Ⅱ colorectal cancer (CRC).

Materials And Methods: This retrospective study was approved by our institutional review board, and the informed consent requirement was waived. From March 2016 to March 2018, 119 Chinese patients with pathologically confirmed stage Ⅱ CRC, available MSI status, and preoperative contrast-enhanced CT images were included in this study. Read More

Vasc Endovascular Surg 2019 Mar 31:1538574419839255. Epub 2019 Mar 31.

2 Department of Radiology, Division of Interventional Radiology, University of Minnesota, Minneapolis, MN, USA.

A 57-year-old male presented with intermittent gastrointestinal bleeding (GIB) 1 year after a successful simultaneous pancreas and kidney transplant. No source could be found after 5 tagged red blood cell studies, 3 computed tomographies (CTs), 7 endoscopies, and 4 catheter angiograms. Review of CTs showed pathologically enlarged superior mesenteric vein branches near a jejunal segment near pancreas graft. Read More

Zhonghua Gan Zang Bing Za Zhi 2019 Mar;27(3):182-191

Transient elastography is a noninvasive, rapid ultrasonic elastography, and assess liver fibrosis by detetcting liver stiffness. Current consensus focuses on understanding influence factors on operation and diagnosis, recommendations for clinical application on detetcting liver fibrosis of chronic liver disease and monitoring development of related complication hepatocelullar carcinoma, high risk esophageal varices, and also summarizes the potential aplication on liver disease screening and liver fibrosis regression assessment. Read More

Dig Liver Dis 2019 Mar 6. Epub 2019 Mar 6.

Paediatric Liver, GI and Transplantation, Hospital Papa Giovanni XXIII Bergamo, Bergamo, Italy. Electronic address:

Objectives: Non-cirrhotic portal vein thrombosis (PVT) is a main cause of portal hypertension in children. We describe the characteristics at presentation and outcome of a cohort of patients with PVT to determine clinical features and predictors of outcome.

Methods: We recorded: (1) Associated factors: prematurity, congenital malformations, neonatal illnesses, umbilical vein catheterization (UVC), deep infections, surgery; (2) congenital and acquired prothrombotic disorders; (3) features at last follow up including survival rate and need for surgery. Read More

Radiol Clin North Am 2019 May 14;57(3):563-583. Epub 2019 Feb 14.

Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive H1307, Stanford, CA 94305, USA.

In the context of chronic liver disease (CLD), sonographic features of hepatic steatosis, cirrhosis, and portal hypertension are discussed and examples are provided. The impact of CLD and hepatocellular carcinoma (HCC) is introduced, providing the rationale for a robust HCC screening and surveillance program for at-risk patients. The American College of Radiology Liver Imaging Reporting and Data System algorithms for screening and surveillance by ultrasound and for the definitive diagnosis of HCC by contrast-enhanced ultrasound are explained, with imaging examples provided. Read More

Radiol Clin North Am 2019 May 8;57(3):549-562. Epub 2019 Feb 8.

Northeastern Ohio Medical University, Southwoods Imaging, 7623 Market Street, Youngstown, OH 44512, USA. Electronic address:

Diffuse liver disease is a substantial world-wide problem. With the combination of conventional ultrasound of the abdomen and elastography-appropriate staging of the patient can be assessed. This information allows for the detection of fibrosis as well as prognosis, surveillance, and prioritization for treatment. Read More

Int J Mol Sci 2019 Mar 28;20(7). Epub 2019 Mar 28.

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei 112, Taiwan.

Hepatopulmonary syndrome (HPS) is a lethal complication of cirrhosis characterized by hypoxia and overt intrapulmonary shunting. In this study, we investigated the effect of caffeine in rats with common bile duct ligation (CBDL)-induced liver cirrhosis and HPS. CBDL rats were randomly allocated to receive caffeine or vehicle for 14 days. Read More

Hepatology 2019 Mar 29. Epub 2019 Mar 29.

Service d'Hépatologie, Centre de Référence des Maladies Vasculaires du Foie, DHU Unity, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon, AP-HP, Clichy, France.

In patients with idiopathic noncirrhotic portal hypertension (INCPH), data on morbi-mortality of abdominal surgery are scarce We retrospectively analyzed the charts of patients with INCPH undergoing abdominal surgery within the VALDIG network. Forty-four patients with biopsy-proven INCPH were included. Twenty-five (57%) patients had ≥1 extrahepatic conditions related with INCPH and 16 (36%) had a history of ascites. Read More

Transpl Int 2019 Mar 29. Epub 2019 Mar 29.

Multivisceral Transplant Unit, Gastroenterology, Dept. of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.

In the field of liver transplantation (LT), satisfactory results have been achieved in recent years in terms of graft and patient survival, but improving patients' health-related quality of life (HRQoL) remains an issue. It is well known that the HRQoL of patients with end-stage liver disease is impaired due to the life-threatening complications of portal hypertension, frequent hospitalizations, and limitations on their social life. This article is protected by copyright. Read More

Surg Case Rep 2019 Mar 28;5(1):48. Epub 2019 Mar 28.

Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachiojishi, Tokyo, 193-0998, Japan.

Background: Pancreatic vascular malformation causes epigastric pain, pancreatitis, portal vein hypertension, bleeding, and rupture. It is a rare disease, with most pancreatic vascular malformations being arteriovenous malformations (AVMs) and the other types of malformations being rare. We report a case of capillary lymphatic malformation (CLM) in the pancreatic uncinate process. Read More

J Pediatr Gastroenterol Nutr 2019 Mar 26. Epub 2019 Mar 26.

Center for Clinical and Translational Research, Seattle Children's Research Institute.

Objectives: In adults, elevated hepatic venous pressure gradients (HVPGs) are correlated with the degree of liver fibrosis on histopathology and predict worse outcomes including variceal bleeding and death. We aimed to examine the association between HVPG measurements, histopathologic findings, and clinical indicators of portal hypertension in children.

Methods: Utilizing retrospective data from 2 pediatric centers between 2006 and 2015, we identified children who underwent simultaneous HVPG measurement and transjugular liver biopsy. Read More

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619836138

1 Stanford University, Stanford, CA, USA.

Drug-induced liver injury (DILI) is a common cause of hepatotoxicity associated with prescription-based and over-the-counter exposure to medications and herbal supplements. Use of unapproved and inadequately tested herbal supplements can cause DILI. Therefore, thorough history-taking on exposure to herbal supplements must be an integral part of clinical evaluation of DILI. Read More

Am J Vet Res 2019 Apr;80(4):378-384

Objective: To assess liver and spleen stiffness in healthy dogs by use of a novel 2-D shear wave elastography (SWE) technique and to investigate the repeatability and reproducibility of the technique.

Animals: 8 healthy adult Beagles.

Procedures: 2-D SWE was performed on each dog to assess liver and spleen stiffness. Read More

Dig Dis Sci 2019 Mar 26. Epub 2019 Mar 26.

Division of Gastroenterology and Hepatology, University of Washington Medical Center, University of Washington, 1959 NE Pacific Street, Box 356175, Seattle, WA, 98195, USA.

Background: Coagulopathy in cirrhosis represents complex coagulation derangements, and thromboelastography (TEG) measures these complex derangements.

Aim: We sought to evaluate associations between TEG parameters and validated measures of cirrhosis severity, which have not been previously investigated.

Materials And Methods: Adults with cirrhosis undergoing liver transplant (LT) were identified. Read More

Gan To Kagaku Ryoho 2019 Mar;46(3):515-517

Dept. of Gastroenterological Surgery, Kanazawa University.

A 27-year-old man was diagnosed with dyskeratosis congenita from DKC1 gene mutation at 9 years of age and had been followed-up regularly.An upper gastrointestinal endoscopy performed for vomiting revealed gastric varices.Further examination resulted in a diagnosis of Stage Ⅳrectal cancer with portal hypertension, splenomegaly, liver, and lung metastasis and he was referred to our department. Read More