Arch Dermatol Res 2014 May 24;306(4):313-330. Epub 2013 Oct 24.
Department of Dermatology, University of California at Davis, 3301 C Street, Sacramento, CA 95816, USA.
Fibrosis is characterized by the excessive deposition of extracellular matrix components eventually resulting in organ dysfunction and failure. In dermatology, fibrosis is the hallmark component of many skin diseases, including systemic sclerosis, graft-versus-host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutanea tarda, restrictive dermopathy and other conditions. Fibrotic skin disorders may be debilitating and impair quality of life. Read More